Lovely place, wonderful host(s), super convenient DT area close to many amenities and attractions. Securing parking is a little problematic in the neighbourhood as there isn't much of it available, even if you get a city permit be prepared to pay quite a bit all together - fyi if you plan to visit with a car. :)
Though I never felt totally unsafe as I have lived Downtown for almost 30 years, for a single female visitor the area may feel a little sketchy at times especially in the evenings. It's not a reflection on the place, just an observation on the neighbourhood.