If you can find a more convenient location to transit options and the heart of Toronto in general, good luck! Not only that, she provided me with great "turn-by-turn" instructions on how to get from the airport to her front door, which was very helpful since this was my first stay with AirBnB!
Communication and responses are virtually instant, so you know that your stay is her top priority.
So when you put it all together, I'm not sure why you would stay anywhere else if you had any business or leisure planned in and around downtown Toronto.