My husband and I stayed at Matt's place for a week during spring break. We couldn't have asked for a better location as we didn't rent a car for the trip. We were able to walk everywhere ( 25 minutes to Fisherman's wharf, 15 to the Empress hotel, 2 minutes to the square, and many restaurants, breweries, and cocktail bars nearby.
Matt's place has everything you would need for an extended or short stay.
Herald Street Brewing is just down the block and we highly recommend that spot, it became our hub.