My sister and I spent a week at Alexis & Nick's condo during a vancouver vacation and found all the comforts of home there. It's located on the edge of Gastown, which is very charming and close to cool night life, but is walkable to downtown, the ferry (to North Van), Stanley Park, the mall & robson street, and other attractions. It's also very close to multiple sky train stations and bus stops.
We were particularly grateful that Alexis and Nick were flexible in accommodating our check in. They are wonderful hosts and we would definitely stay again!