Would highly recommend Antwerp for a city break. My daughter and I stayed for a weekend at Brams studio. Located very close to the station but on a busy road so noisy. It was very hot when we stayed so had the doors to the balcony wide open.
Close to the town - tram stop just along the road although we walked everywhere easily.
Brams studio is clean and comfortable. The building is a bit run down in the communal areas but the studio is fine and as two girls staying, we felt safe.