I stayed in the house for a month with my 4-year old daughter. I am born and raised Argentine so we didn't live the tourist life. We spent lot of time in the house; used the outdoor space and cooked every day. This place really felt like home and that meant everything to me. In fact, both my daughter and I refer to it, still, as "our house in Buenos Aires".
In practical terms, it doesn't get better in terms of location: it's safe to get in and out, there are dozens of restaurants/cafes around, and it's next to a supermarket. The house is spacious, the light is amazing, it has outdoor space, and the style is curated with impecable taste. The house looks modern, but it is one of those original older homes from Palermo (which you cannot not love). Be kind to it and expect the aches of an older home, but do not hesitate to contact the host; she'll have whatever you need answered/fixed asap.