Me and my partner had the best time at Jorge Y Celeste. The room is incredibly beautiful and cozy, and the house has a great location: it's close to the subway - which almost takes you anywhere - but also a neighbor to the San Telmo square and a 15 minutes walk from the Florida Street and the Plaza de Mayo, some great places to visit and solve any trip matters you may have. Otherwise, the only thing you should consider is the stairs, to get to the room you have to climb some marbled steps.
It's good to know that Jorge Y Celeste's is also very close to many little greengrocerys, and whats the best, the San Telmo's oficial Market: they have fresh and various vegetables - please try the Portobelo Mushrooms. So when you decide to rest and save some money, you can buy a bag of vegetables, nuts, and fruit, and make a nice healthy meal at the room's petit cuisine.
Also, after our great walks - the city is all plain, and invites you to walk all over it, so if your a walker, bring nice comfortable shoes - resting in the house's cute terrace and petting Raja the cat, was one of our favorite relaxing things.
And finally, Jorge and Celeste themselves are very sweet and helpful.
So, to sum up, I would not think twice.