La Casa de Bulnes is a great place to stay! My boyfriend and I stayed there for about 2.5 weeks. It was a great way to get familiar with the city, but also not feel isolated. Mariana and Eli are absolute sweethearts, as are Dani and Ceci, with whom we've hung out multiple times (usually around that awesome parilla). It's a safe area, close to shops, numerous bus lines to get you anywhere in the city (the two subway lines are a bit of a walk, so we mostly took the bus), and a pleasant walk from the very popular areas of Palermo Viejo (on Honduras and El Salvador Streets around Plaza Serrano). They were very helpful with their suggestions throughout our stay. There's a very nice cleaning lady, Marina, who comes twice a week, and can clean your room or change sheets and towels as you wish. The roof terrace is wonderful.
Our room was spacious, clean, and well furnished. We prefer not to sleep with the AC on, so for the most part we were able to sleep with the doors open and only the shutters closed, though there were a few nights when it was simply too hot to do that. It's the summer, after all, but on most days there's a really nice breeze in the evening. Note, this room is right next to the dining room and kitchen, so if you are very sensitive to different smells, this may be a distraction. Depending on how many people are in the house, and your personal preferences for getting up and going to bed (an early bird vs. a night owl), you may also hear some noise in either the morning or evening (again, depending on the guests in the house). I'm used to sleeping with ear plugs, so it didn't really bother me. Eli was very considerate and let me know whenever they were using the parilla to close the doors to our room so that the smoke doesn't waft in. A few times, though, I could smell cigarette smoke from the patio when there were guests who smoked, but luckily those were very few and far between (and I'm one of those people super sensitive to smells, so normal people probably wouldn't smell a thing!).
All in all, we had a wonderful stay, and it was great to have a place where we could have privacy just by closing the door, but also be around other people. Everyone was really nice and welcoming, I highly recommend this place!