This was for me a very comfortable apartment to stay in.
If you cook, the burners on the left of the stove are good to go, but the pots and pans available may need some extra space to line up so creative adaptation may be required. The oven's temperature settings were worn off the control knob, so I didn't mess with that, especially since it's all gas powered. I myself usually do longer stays, so the kitchen is a space of interest. This one can work if you are creative, the essentials are there, it just might be a little more challenging if you typically cook on multiple burners at once. There are some grocery stores within a few blocks, under a 5min. walk. There's an electric kettle for instant coffee or tea.
The bed is super comfortable, the smart TV is a nice size, apartment and street noise were generally mild. I didn't have any problems with the internet connection but I didn't need regular video feeds or anything requiring much bandwidth.
I ended up walking the city but there are Sube stops within 10min. walk on Santa Fe that should bring you to a comfortable walking distance from most places. Or Uber is available and quite reasonable. I definitely wore myself out several times because the walks ended up quite long. It's a great city with many areas to explore, so hard to say which might be most central, but this is definitely a good place to start. Palermo felt safe as did most of the city. I had a great experience staying here and would gladly return if another trip to Buenos Aires is in my future.