Table:
Month(s)
0	3	6	9	12
Primary outcome
Average overall knee pain severity over the previous week (0 to 10 NRS)	✓	✓	✓	✓	✓
Secondary outcomes
Imaging assessments:
MRI of signal knee	✓	✓
Clinical assessments:
Knee examination	✓
Self-reported questionnaires:
WOMAC 3.1 (pain, stiffness and function) - five-point Likert scale	✓	✓	✓	✓	✓
ICOAP	✓	✓	✓	✓	✓
11-point NRS for:	✓	✓	✓	✓	✓
Worst knee pain severity,/ global disease activity and pain in other joints over the past week
Satisfaction with knee function over the past 2 days
Knee pain, aching or stiffness over the past month (no days to all days)
Globala improvement in knee problem, pain and function	✓	✓	✓	✓
Pain elsewhere (pain manikin)	✓	✓	✓	✓	✓
Duration of knee pain over the past 12 months (<7 days, 1 to 4 weeks, >1 month, <3 months or >3 months)	✓
Onset of knee pain (last 12 months, 1 to 5 years, 5 to 10 years or 10 years or more)	✓
Quality of life: SF-12 v2 and OAQoL [40]	✓	✓	✓
EuroQol EQ-5D [41,42]	✓	✓	✓
Depression and anxiety: HADS	✓	✓	✓
Resource use:	✓	✓	✓
Demographics and medical history	✓
Brief medication questionnaire	✓	✓	✓	✓
Concomitant medicationb	✓	✓	✓	✓	✓
Adverse eventsb	✓	✓	✓	✓

Express the illustration as Markdown code.

|  | <COLSPAN=5> Month(s) | 
 | --- | --- | --- | --- | --- | --- | 
 |  | 0 | 3 | 6 | 9 | 12 | 
 | Primary outcome |  |  |  |  |  | 
 | Average overall knee pain severity over the previous week (0 to 10 NRS) | ✓ | ✓ | ✓ | ✓ | ✓ | 
 | Secondary outcomes |  |  |  |  |  | 
 | Imaging assessments: |  |  |  |  |  | 
 | MRI of signal knee | ✓ |  | ✓ |  |  | 
 | Clinical assessments: |  |  |  |  |  | 
 | Knee examination | ✓ |  |  |  |  | 
 | Self-reported questionnaires: |  |  |  |  |  | 
 | WOMAC 3.1 (pain, stiffness and function) - five-point Likert scale | ✓ | ✓ | ✓ | ✓ | ✓ | 
 | ICOAP | ✓ | ✓ | ✓ | ✓ | ✓ | 
 | 11-point NRS for: | ✓ | ✓ | ✓ | ✓ | ✓ | 
 | Worst knee pain severity,/ global disease activity and pain in other joints over the past week |  |  |  |  |  | 
 | Satisfaction with knee function over the past 2 days |  |  |  |  |  | 
 | Knee pain, aching or stiffness over the past month (no days to all days) |  |  |  |  |  | 
 | Globala improvement in knee problem, pain and function |  | ✓ | ✓ | ✓ | ✓ | 
 | Pain elsewhere (pain manikin) | ✓ | ✓ | ✓ | ✓ | ✓ | 
 | Duration of knee pain over the past 12 months (<7 days, 1 to 4 weeks, >1 month, <3 months or >3 months) | ✓ |  |  |  |  | 
 | Onset of knee pain (last 12 months, 1 to 5 years, 5 to 10 years or 10 years or more) | ✓ |  |  |  |  | 
 | Quality of life: SF-12 v2 and OAQoL [40] | ✓ |  | ✓ |  | ✓ | 
 | EuroQol EQ-5D [41,42] | ✓ |  | ✓ |  | ✓ | 
 | Depression and anxiety: HADS | ✓ |  | ✓ |  | ✓ | 
 | Resource use: | ✓ |  | ✓ |  | ✓ | 
 | Demographics and medical history | ✓ |  |  |  |  | 
 | Brief medication questionnaire |  | ✓ | ✓ | ✓ | ✓ | 
 | Concomitant medicationb | ✓ | ✓ | ✓ | ✓ | ✓ | 
 | Adverse eventsb |  | ✓ | ✓ | ✓ | ✓ |