Table:
Variables	Univariate analysis	Multivariate analysis
Hazard Ratio	95% CI	P value	Hazard Ratio	95% CI	P value
Sex	1.15	0.70–1.89	0.58	1.03	0.60–1.77	0.91
Age	0.93	0.59–1.46	0.75	0.76	0.45–1.29	0.31
Tumor size	0.94	0.47–1.90	0.87	0.77	0.35–1.71	0.52
Differentiation	1.30	0.72–2.37	0.38	1.07	0.54–2.14	0.84
Tumor location	1.09	0.68–1.75	0.71	1.10	0.54–2.14	0.84
Depth of invasion	1.49	0.80–2.76	0.21	1.81	0.76–4.33	0.18
LN metastasis	1.31	0.73–2.34	0.36	1.31	0.62–2.79	0.48
Distant metastasis	0.83	0.26–2.63	0.75	0.66	0.97–4.45	0.67
TNM stage	1.30	0.77–2.19	0.33	0.70	0.30–1.63	0.41
HER2 expression	1.61	0.94–2.74	0.08	5.98	0.97–36.72	0.054
HER3 expression	2.20	1.38–3.52	0.001	1.82	0.93–3.57	0.08
HER2-HER3 co-expression	1.56	0.88–2.75	0.13	6.21	0.95–40.89	0.057
Akt expression	1.79	1.04–3.08	0.04	1.64	0.87–3.12	0.13
p-Akt expression	1.42	0.87–2.27	0.15	0.88	0.46–1.68	0.69
mTOR expression	1.33	0.84–2.11	0.22	1.14	0.64–2.03	0.67
p-mTOR expression	1.88	1.19–2.99	0.01	1.47	0.75–2.87	0.26

Continue parse the figure with markdown style: | <ROWSPAN=2> Variables | <COLSPAN=3> Univariate analysis | <COLSPAN=3> Multivariate analysis | 
 | Hazard Ratio | 95% CI | P value | Hazard Ratio | 95% CI | P value | 
 | --- | --- | --- | --- | --- | --- | --- | 
 | Sex | 1.15 | 0.70–1.89 | 0.58 | 1.03 | 0.60–1.77 | 0.91 | 
 | Age | 0.93 | 0.59–1.46 | 0.75 | 0.76 | 0.45–1.29 | 0.31 | 
 | Tumor size | 0.94 | 0.47–1.90 | 0.87 | 0.77 | 0.35–1.71 | 0.52 | 
 | Differentiation | 1.30 | 0.72–2.37 | 0.38 | 1.07 | 0.54–2.14 | 0.84 | 
 | Tumor location | 1.09 | 0.68–1.75 | 0.71 | 1.10 | 0.54–2.14 | 0.84 | 
 | Depth of invasion | 1.49 | 0.80–2.76 | 0.21 | 1.81 | 0.76–4.33 | 0.18 | 
 | LN metastasis | 1.31 | 0.73–2.34 | 0.36 | 1.31 | 0.62–2.79 | 0.48 | 
 | Distant metastasis | 0.83 | 0.26–2.63 | 0.75 | 0.66 | 0.97–4.45 | 0.67 | 
 | TNM stage | 1.30 | 0.77–2.19 | 0.33 | 0.70 | 0.30–1.63 | 0.41 | 
 | HER2 expression | 1.61 | 0.94–2.74 | 0.08 | 5.98 | 0.97–36.72 | 0.054 | 
 | HER3 expression | 2.20 | 1.38–3.52 | 0.001 | 1.82 | 0.93–3.57 | 0.08 | 
 | HER2-HER3 co-expression | 1.56 | 0.88–2.75 | 0.13 | 6.21 | 0.95–40.89 | 0.057 | 
 | Akt expression | 1.79 | 1.04–3.08 | 0.04 | 1.64 | 0.87–3.12 |

0.13 | 
 | p-Akt expression | 1.42 | 0.87–2.27 | 0.15 | 0.88 | 0.46–1.68 | 0.69 | 
 | mTOR expression | 1.33 | 0.84–2.11 | 0.22 | 1.14 | 0.64–2.03 | 0.67 | 
 | p-mTOR expression | 1.88 | 1.19–2.99 | 0.01 | 1.47 | 0.75–2.87 | 0.26 |