Table:
Preferred term	Number of patients	Number (%) patients
LD 5-FU(n = 7)	HD 5-FU(n = 45)	Total(n = 52)
Grade 3	Grade 4	Grade 3	Grade 4	Grade 3	Grade 4
Leucopenia	2 [2]	0	8 [8]	[1]	10 (19)	1 (2)
Diarrhoea	0	0	6 [5]	0	6 (12)	0 (0)
Vomiting	1 [1]	0	5 [3]	0	6 (12)	0 (0)
Rash	2 [2]	0	4 [4]	0	6 (12)	0 (0)
Acne	2 [2]	0	3 [3]	0	5 (10)	0 (0)
Asthenia	2 [2]	0	3 [1]	1	5 (10)	1 (2)
Intestinal obstruction	0	0	4	1	4 (8)	1 (2)
Abdominal pain	0	0	3	0	3 (6)	0 (0)
Mucous membrane disorder	0	0	3 [3]	0	3 (6)	0 (0)
Dyspnoea	0	0	3 [3]	1	3 (6)	1 (2)
Atrial fibrillation	0	0	2	0	2 (4)	0 (0)
Deep thrombophlebitis	0	0	2 [1]	0	2 (4)	0 (0)
Gamma glutamyl transpeptidase increased	0	0	2 [1]	0	2 (4)	0 (0)
Hypokalaemia	0	0	2	0	2 (4)	0 (0)
Liver function test abnormal	0	0	2 [1]	0	2 (4)	0 (0)
Skin disorder	0	0	2 [2]	0	2 (4)	0 (0)
Thrombosis	0	0	2	0	2 (4)	0 (0)
Urinary tract infection	0	0	2	0	2 (4)	0 (0)
Weight loss	0	0	2 [1]	0	2 (4)	0 (0)

Parse the illustration content behind with markdown code: | Preferred term | <COLSPAN=4> Number of patients | <COLSPAN=2> Number (%) patients | 
 | --- | --- | --- | --- | --- | --- | --- | 
 |  | <COLSPAN=2> LD 5-FU(n = 7) | <COLSPAN=2> HD 5-FU(n = 45) | <COLSPAN=2> Total(n = 52) | 
 |  | Grade 3 | Grade 4 | Grade 3 | Grade 4 | Grade 3 | Grade 4 | 


| Leucopenia | 2 [2] | 0 | 8 [8] | [1] | 10 (19) | 1 (2) | 
 | Diarrhoea | 0 | 0 | 6 [5] | 0 | 6 (12) | 0 (0) | 
 | Vomiting | 1 [1] | 0 | 5 [3] | 0 | 6 (12) | 0 (0) | 
 | Rash | 2 [2] | 0 | 4 [4] | 0 | 6 (12) | 0 (0) | 
 | Acne | 2 [2] | 0 | 3 [3] | 0 | 5 (10) | 0 (0) | 
 | Asthenia | 2 [2] | 0 | 3 [1] | 1 | 5 (10) | 1 (2) | 
 | Intestinal obstruction | 0 | 0 | 4 | 1 | 4 (8) | 1 (2) | 
 | Abdominal pain | 0 | 0 | 3 | 0 | 3 (6) | 0 (0) | 
 | Mucous membrane disorder | 0 | 0 | 3 [3] | 0 | 3 (6) | 0 (0) | 
 | Dyspnoea | 0 | 0 | 3 [3] | 1 | 3 (6) | 1 (2) | 
 | Atrial fibrillation | 0 | 0 | 2 | 0 | 2 (4) | 0 (0) | 
 | Deep thrombophlebitis | 0 | 0 | 2 [1] | 0 | 2 (4) | 0 (0) | 
 | Gamma glutamyl transpeptidase increased | 0 | 0 | 2 [1] | 0 | 2 (4) | 0 (0) | 
 | Hypokalaemia | 0 | 0 | 2 | 0 | 2 (4) | 0 (0) | 
 | Liver function test abnormal | 0 | 0 | 2 [1] | 0 | 2 (4) | 0 (0) | 
 | Skin disorder | 0 | 0 | 2 [2] | 0 | 2 (4) | 0 (0) | 
 | Thrombosis | 0 | 0 | 2 | 0 | 2 (4) | 0 (0) | 
 | Urinary tract infection | 0 | 0 | 2 | 0 | 2 (4) | 0 (0) | 
 | Weight loss | 0 | 0 | 2 [1] | 0 | 2 (4) | 0 (0) |