Table:
GEP signature	Methods
UAMS 70-gene [49]	Derived by comparing expression of profiles of patients with top and bottom quartile of survival treated on total therapy II
IFM signature [50]	Derived by comparing expression of profiles of patients with good and poor outcome in IFM trials
Centrosome index [51]	Based on expression of constituents of the centrosome
HZD cell death signature [52]	Signature derived from genes homozygously deleted in myeloma as detected by array comparative genomic hybridization
IL6-HMCL signature [53]	13-gene signature from genes induced upon IL6 stimulation of human myeloma cells lines
Proliferation index [54]	Curated signature based on proliferation genes
EMC 92-gene signature [55]	92-gene signature based on differentially expressed genes between patient with good and poor outcome on HOVON trial
Chromosome instability genomic event count (CINGEC) signature [56]	Based on differentially expressed genes between patients with the top and bottom quartile of genomic instability score based on number of genetic abnormalities identified by array comparative genomic hybridization

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| GEP signature | Methods | 
 | --- | --- | 
 | UAMS 70-gene [49] | Derived by comparing expression of profiles of patients with top and bottom quartile of survival treated on total therapy II | 
 | IFM signature [50] | Derived by comparing expression of profiles of patients with good and poor outcome in IFM trials | 
 | Centrosome index [51] | Based on expression of constituents of the centrosome | 
 | HZD cell death signature [52] | Signature derived from genes homozygously deleted in myeloma as detected by array comparative genomic hybridization | 
 | IL6-HMCL signature [53] | 13-gene signature from genes induced upon IL6 stimulation of human myeloma cells lines | 
 | Proliferation index [54] | Curated signature based on proliferation genes | 
 | EMC 92-gene signature [55] | 92-gene signature based on differentially expressed genes between patient with good and poor outcome on HOVON trial | 
 | Chromosome instability genomic event count (CINGEC) signature [56] | Based on differentially expressed genes between patients with the top and bottom quartile of genomic instability score based on number of genetic abnormalities identified by array comparative genomic hybridization |