Table:
Baseline characteristics	Mean (SD), median (IQR) or number (%)	Correlation with frailty index at follow-up
Age (years), mean (SD)	70.0 (7.36)	0.3012***
Female, no. (%)	2982 (54.4)	0.128***
Personality traits, mean (SD)
Extraversion	3.15 (0.55)	−0.249***
Agreeableness	3.51 (0.48)	0.015
Openness	2.86 (0.56)	−0.165***
Neuroticism	2.06 (0.58)	0.161***
Conscientiousness	3.27 (0.50)	−0.224***
Household wealth (£), median (IQR)	241,102 (131,215–418,219)	−0.292***
Smoking status, no. (%)	0.103***
Never	1956 (36.8)
Ex-smoker	2822 (53.1)
Current smoker	536 (10.1)
Physical activity, no. (%)	−0.415***
Sedentary	279 (5.25)
Low	1294 (24.4)
Medium	2749 (51.7)
High	992 (18.7)
Frailty index score, median (IQR)	0.068 (0.022–0.136)	0.830***

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| Baseline characteristics | Mean (SD), median (IQR) or number (%) | Correlation with frailty index at follow-up | 
 | --- | --- | --- | 
 | Age (years), mean (SD) | 70.0 (7.36) | 0.3012*** | 
 | Female, no. (%) | 2982 (54.4) | 0.128*** | 
 | <COLSPAN=3> Personality traits, mean (SD) | 
 | Extraversion | 3.15 (0.55) | −0.249*** | 
 | Agreeableness | 3.51 (0.48) | 0.015 | 
 | Openness | 2.86 (0.56) | −0.165*** | 
 | Neuroticism | 2.06 (0.58) | 0.161*** | 
 | Conscientiousness | 3.27 (0.50) | −0.224*** | 
 | Household wealth (£), median (IQR) | 241,102 (131,215–418,219) | −0.292*** | 
 | Smoking status, no. (%) |  | 0.103*** | 
 | Never | 1956 (36.8) |  | 
 | Ex-smoker | 2822 (53.1) |  | 
 | Current smoker | 536 (10.1) |  | 
 | Physical activity, no. (%) |  | −0.415*** | 
 | Sedentary | 279 (5.25) |  | 
 | Low | 1294 (24.4) |  | 
 | Medium | 2749 (51.7) |  | 
 | High | 992 (18.7) |  | 
 | Frailty index score, median (IQR) | 0.068 (0.022–0.136) | 0.830*** |