Table:
Study	Mutation(s)	Aβ42	Tau	pTau	Comments
Moonis et al. (69)6 MC6 Unrelated controls	PSEN-1 C410Y, PSEN-1 P242H, and R352H	↓	N.S.	Not tested	MC EYO −8 ± 3
Ringman et al. (74)20 MC9 NC	PSEN-1 A431E, PSEN-1 L235V, PSEN-1 G206A, APP V717I	↓ (trend)	↑	↑	MC EYO ~−12NC EYO −9 ± 12
Fortea et al. (70)8 MC5 NC	PSEN-1 L286P, PSEN-1 M139T	↓ (trend)	N.S.	N.S.	MC EYO −6 ± 10NC EYO −7 ± 9
Scholl et al. (71)4 MC7 Unrelated controls	APP KM670/671 NL, APP E693G, PSEN-1 H163Y	↓	↑	↑
Reiman et al. (72)10 MC10 NC	PSEN-1 E280A (API)	↑	N.S.	N.S.	MC EYO ~−25NC EYO ~−26
Ringman et al. (75)13 MC5 NC	PSEN-1 A431E, PSEN-1 L235V, PSEN-1 S212Y, APP V717I	↓	↑	↑	MC EYO −12 ± 10NC EYO −6 ± 14
Bateman et al. (11)88 MC40 NC	Many (DIAN)	↓ at EYO −10 and closer to EAO	↑ at EYO −15 and closer to EAO	Not shown
Thordardottir et al. (76)10 MC12 NC	APP KM670/671 NL, APP E693G, PSEN-1 H163Y, PSEN-1 I143T	↓	↑	↑	MC EYO −7 ± 9NC EYO −7 ± 12
Fleisher et al. (12)32 MC22 NC	PSEN-1 E280A (API)	↓ at EYO −25 and closer to EAO	↑ at EYO −20 and closer to EAO	↑ at EYO −18 and closer to EAO

Transcribe the illustration into Markdown format.

| Study | Mutation(s) | Aβ42 | Tau | pTau | Comments | 
 | --- | --- | --- | --- | --- | --- | 
 | Moonis et al. (69)6 MC6 Unrelated controls | PSEN-1 C410Y, PSEN-1 P242H, and R352H | ↓ | N.S. | Not tested | MC EYO −8 ± 3 | 
 | Ringman et al. (74)20 MC9 NC | PSEN-1 A431E, PSEN-1 L235V, PSEN-1 G206A, APP V717I | ↓ (trend) | ↑ | ↑ | MC EYO ~−12NC EYO −9 ± 12 | 
 | Fortea et al. (70)8 MC5 NC | PSEN-1 L286P, PSEN-1 M139T | ↓ (trend) | N.S. | N.S. | MC EYO −6 ± 10NC EYO −7 ± 9 | 
 | Scholl et al. (71)4 MC7 Unrelated controls | APP KM670/671 NL, APP E693G, PSEN-1 H163Y | ↓ | ↑ | ↑ |  | 
 | Reiman et al. (72)10 MC10 NC | PSEN-1 E280A (API) | ↑ | N.S. | N.S. | MC EYO ~−25NC EYO ~−26 | 
 | Ringman et al. (75)13 MC5 NC | PSEN-1 A431E, PSEN-1 L235V, PSEN-1 S212Y, APP V717I | ↓ | ↑ | ↑ | MC EYO −12 ± 10NC EYO −6 ± 14 | 
 | Bateman et al. (11)88 MC40 NC | Many (DIAN) | ↓ at EYO −10 and closer to EAO | ↑ at EYO −15 and closer to EAO | Not shown |  | 
 | Thordardottir et al. (76)10 MC12 NC | APP KM670/671 NL, APP E693G, PSEN-1 H163Y, PSEN-1 I143T | ↓ | ↑ | ↑ | MC EYO −7 ± 9NC EYO −7 ± 12 | 
 | Fleisher et al. (12)32 MC22 NC | PSEN-1 E280A (API) | ↓ at EYO −25 and closer to EAO | ↑ at EYO −20 and closer to EAO | ↑ at EYO −18 and closer to EAO |  |