Table:
Toxicity	DA	DClo	P-value
% grade 3–4	Mean grade	% grade 3–4	Mean grade
Course 1
Nausea	5%	0.8	10%	1.0	0.01
Oral	3%	0.7	2%	0.7	0.4
Diarrhoea	12%	1.1	8%	1.0	0.12
Cardiac	7%	0.4	5%	0.3	0.3
Liver AST	6%	0.6	6%	0.5	0.6
Liver ALT	4%	0.6	6%	0.7	0.3
Bilirubin	7%	0.8	5%	0.7	0.04
Median days to neutrophil recovery	20	24	<0.0001*
Median days to platelet recovery	21	24	<0.0001*
Mean blood units	11.0	9.5	0.0002
Mean platelet units	12.9	9.8	<0.0001
Mean days antibiotics	19.7	16.7	<0.0001
Mean hospitalisation days	33.8	31.4	<0.0001

Course 2
Nausea	4%	0.7	7%	0.9	0.004
Oral	1%	0.4	1%	0.4	0.9
Diarrhoea	4%	0.6	9%	0.7	0.19
Cardiac	2%	0.1	2%	0.2	0.7
Liver AST	1%	0.2	4%	0.4	0.06
Liver ALT	3%	0.4	2%	0.6	0.004
Bilirubin	3%	0.5	5%	0.4	0.4
Median days to neutrophil recovery	20	21	0.2*
Median days to platelet recovery	25	24	0.3*
Mean blood units	6.3	6.4	0.9
Mean platelet units	6.0	5.7	0.03
Mean days antibiotics	9.4	9.6	0.6
Mean hospitalisation days	25.0	23.4	0.01

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| Toxicity | <COLSPAN=2> DA | <COLSPAN=2> DClo | P-value | 
 |  | % grade 3–4 | Mean grade | % grade 3–4 | Mean grade |  | 
 | --- | --- | --- | --- | --- | --- | 
 | <COLSPAN=6> Course 1 | 
 | Nausea | 5% | 0.8 | 10% | 1.0 | 0.01 | 
 | Oral | 3% | 0.7 | 2% | 0.7 | 0.4 | 
 | Diarrhoea | 12% | 1.1 | 8% | 1.0 | 0.12 | 
 | Cardiac | 7% | 0.4 | 5% | 0.3 | 0.3 | 
 | Liver AST | 6% | 0.6 | 6% | 0.5 | 0.6 | 
 | Liver ALT | 4% | 0.6 | 6% | 0.7 | 0.3 | 
 | Bilirubin | 7% | 0.8 | 5% | 0.7 | 0.04 | 
 | Median days to neutrophil recovery | 20 |  | 24 |  | <0.0001* | 
 | Median days to platelet recovery | 21 |  | 24 |  | <0.0001* | 
 | Mean blood units | 11.0 |  | 9.5 |  | 0.0002 | 
 | Mean platelet units | 12.9 |  | 9.8 |  | <0.0001 | 
 | Mean days antibiotics | 19.7 |  | 16.7 |  | <0.0001 | 
 | Mean hospitalisation days | 33.8 |  | 31.4 |  | <0.0001 | 
 | <COLSPAN=6>  | 
 | <COLSPAN=6> Course 2 | 
 | Nausea | 4% | 0.7 | 7% | 0.9 | 0.004 | 
 | Oral | 1% | 0.4 | 1% | 0.4 | 0.9 | 
 | Diarrhoea | 4% | 0.6 | 9% | 0.7 | 0.19 | 
 | Cardiac | 2% | 0.1 | 2% | 0.2 | 0.7 | 
 | Liver AST | 1% | 0.2 | 4% | 0.4 | 0.06 | 
 | Liver ALT | 3% | 0.4 | 2% | 0.6 | 0.004 | 
 | Bilirubin | 3% | 0.5 | 5% | 0.4 | 0.4 | 
 | Median days to neutrophil recovery | 20 |  | 21 |  | 0.2* | 
 | Median days to platelet recovery | 25 |  | 24 |  | 0.3* | 
 | Mean blood units | 6.3 |  | 6.4 |  | 0.9 | 
 | Mean platelet units | 6.0 |  | 5.7 |  | 0.03 | 
 | Mean days antibiotics | 9.4 |  | 9.6 |  | 0.6 | 
 | Mean hospitalisation days | 25.0 |  | 23.4 |  | 0.01 |