Table:
Name of the senolytic agents	Targeted molecular	Major studied types of cell/organ/animal	Reference
AP20187	p16INK4A expressing adipocytes	Transgenic INK-ATTAC progeroid mice (in vivo)	Baker et al., 2011
Rapamycin or sirolimus	mTOR complex mTORC1	(I) Partly suppressed the SASP, especially IL-1α in IR-induced SNCs (in vitro) (II) Repressed the proliferation of senescent tumor cells after subcutaneous implantation (in vivo)	Laberge et al., 2015
siRNA	EFNB1 or 3, PI3KCD, p21, BCL-xL, PAI-2	Senescent human abdominal subcutaneous preadipocytes (in vitro)	Zhu et al., 2015
Dasatinib (D)/BMS-354825 and quercetin (Q)	D: multiple tyrosine kinases Q: PI3K	(I) Selectively killing of both senescent preadipocytes, endothelial cells MEFs and MSCs (in vitro) (II) Senile mice (>24 months-old) (in vivo)
(I) Smomelotinib (CYT387) and INCB18424 (II) Ruxolitinib (INCB18424)	JAK pathway	(I) Senescent human primary. preadipocytes (in vitro) (II) 24-month-old C57BL/6 male mice (in vivo)	Xu et al., 2015
ABT-737	BCL-2, BCL-W, and BCL-XL	(I) Irradiated male mice (in vivo) (II) Double-transgenic K5-rtTA/tet-p14 mice	Yosef et al., 2016
ABT263 (a paralog of ABT-737)	BCL-2 and BCL-xL	Sublethally irradiated mice or normally aged mice (in vivo)	Chang et al., 2016
KU-60019	ATM kinase	(I) Human diploid fibroblasts, ATM-deficient GM02052 fibroblasts (in vivo) (II) Facilitating wound healing in aged mice (in vivo)	Kang et al., 2017
17-DMAG	HSP90	(I) Senescent Ercc1-/- primary MEFs II. Ercc1-/Δ mouse (model of a human progeroid syndrome)	Fuhrmann-Stroissnigg et al., 2017
Fisetin, A1331852, A1155463	Fisetin: PI3K/Akt pathway; A1331852 and A1155463: targeting BCL-XL	Specifically inducing apoptosis in SNCs. Fisetin: senescent HUVECs. A1331852 and A1155463: senescent HUVECs and IMR-90 cells	Zhu et al., 2017
FOXO4-DRI	A modified FOXO4-p53 interfering peptide	Selectively induced apoptosis of senescent cells in vitro and in aging mice	Baar et al., 2017

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| Name of the senolytic agents | Targeted molecular | Major studied types of cell/organ/animal | Reference | 
 | --- | --- | --- | --- | 
 | AP20187 | p16INK4A expressing adipocytes | Transgenic INK-ATTAC progeroid mice (in vivo) | Baker et al., 2011 | 
 | Rapamycin or sirolimus | mTOR complex mTORC1 | (I) Partly suppressed the SASP, especially IL-1α in IR-induced SNCs (in vitro) (II) Repressed the proliferation of senescent tumor cells after subcutaneous implantation (in vivo) | Laberge et al., 2015 | 
 | siRNA | EFNB1 or 3, PI3KCD, p21, BCL-xL, PAI-2 | Senescent human abdominal subcutaneous preadipocytes (in vitro) | Zhu et al., 2015 | 
 | Dasatinib (D)/BMS-354825 and quercetin (Q) | D: multiple tyrosine kinases Q: PI3K | (I) Selectively killing of both senescent preadipocytes, endothelial cells MEFs and MSCs (in vitro) (II) Senile mice (>24 months-old) (in vivo) |  | 
 | (I) Smomelotinib (CYT387) and INCB18424 (II) Ruxolitinib (INCB18424) | JAK pathway | (I) Senescent human primary. preadipocytes (in vitro) (II) 24-month-old C57BL/6 male mice (in vivo) | Xu et al., 2015 | 
 | ABT-737 | BCL-2, BCL-W, and BCL-XL | (I) Irradiated male mice (in vivo) (II) Double-transgenic K5-rtTA/tet-p14 mice | Yosef et al., 2016 | 
 | ABT263 (a paralog of ABT-737) | BCL-2 and BCL-xL | Sublethally irradiated mice or normally aged mice (in vivo) | Chang et al., 2016 | 
 | KU-60019 | ATM kinase | (I) Human diploid fibroblasts, ATM-deficient GM02052 fibroblasts (in vivo) (II) Facilitating wound healing in aged mice (in vivo) | Kang et al., 2017 | 
 | 17-DMAG | HSP90 | (I) Senescent Ercc1-/- primary MEFs II. Ercc1-/Δ mouse (model of a human progeroid syndrome) | Fuhrmann-Stroissnigg et al., 2017 | 
 | Fisetin, A1331852, A1155463 | Fisetin: PI3K/Akt pathway; A1331852 and A1155463: targeting BCL-XL | Specifically inducing apoptosis in SNCs. Fisetin: senescent HUVECs. A1331852 and A1155463: senescent HUVECs and IMR-90 cells | Zhu et al., 2017 | 
 | FOXO4-DRI | A modified FOXO4-p53 interfering peptide | Selectively induced apoptosis of senescent cells in vitro and in aging mice | Baar et al., 2017 |