Table:
univariate	multivariate
initial model	final model
HR	p	HR	p	HR	p
age>65 years	2.99	<0.0001	3.53	<0.0001	3.43	<0.0001
male sex	1.86	0.0018	1.84	0.0030	1.80	0.0038
ALC>14 × 109/L	1.67	0.0062	1.34	0.17	-
β2M>1 × ULN	1.43	<0.0001	1.51	0.06	1.59	0.029
LNR ≥3	3.06	<0.0001	1.20	0.59	-
Binet stage	<0.0001
A	ref	ref	ref
B	3.20	2.19	0.0352	2.77	<0.0001
C	4.95	2.86	0.0028	3.68	<0.0001
Rai stage	<0.0001
0	ref	ND
I-II	1.66	ND
III-IV	5.08	ND
CD38>30%	1.73	0.0038	1.03	0.88	-
ZAP-70>20%	1.53	0.0204	1.04	0.83	-
Unmutated IGHV	2.46	<0.0001	2.04	0.0008	2.04	0.0003
del17p	3.44	<0.0001	2.14	0.0015	2.06	0.0022
del11q	1.39	0.248	ND
Year of diagnosis	0.0130	(in model as strata)*	(in model as strata)*
<2001	ref
2001-2005	1.46
>2005	2.34
Therapy	0.106	ND
Chemotherapy	ref
Immunochemotherapy	0.6

Transcribe the illustration into Markdown format.

|  | univariate |  |  |  | <COLSPAN=2> multivariate | 
 | --- | --- | --- | --- | --- | --- | --- | 
 |  |  |  | <COLSPAN=2> initial model | <COLSPAN=2> final model | 
 |  | HR | p | HR | p | HR | p | 
 | age>65 years | 2.99 | <0.0001 | 3.53 | <0.0001 | 3.43 | <0.0001 | 
 | male sex | 1.86 | 0.0018 | 1.84 | 0.0030 | 1.80 | 0.0038 | 
 | ALC>14 × 109/L | 1.67 | 0.0062 | 1.34 | 0.17 | - |  | 
 | β2M>1 × ULN | 1.43 | <0.0001 | 1.51 | 0.06 | 1.59 | 0.029 | 
 | LNR ≥3 | 3.06 | <0.0001 | 1.20 | 0.59 | - |  | 
 | Binet stage |  | <0.0001 |  |  |  |  | 
 | A | ref |  | ref |  | ref |  | 
 | B | 3.20 |  | 2.19 | 0.0352 | 2.77 | <0.0001 | 
 | C | 4.95 |  | 2.86 | 0.0028 | 3.68 | <0.0001 | 
 | Rai stage |  | <0.0001 |  |  |  |  | 
 | 0 | ref |  | ND |  |  |  | 
 | I-II | 1.66 |  | ND |  |  |  | 
 | III-IV | 5.08 |  | ND |  |  |  | 
 | CD38>30% | 1.73 | 0.0038 | 1.03 | 0.88 | - |  | 
 | ZAP-70>20% | 1.53 | 0.0204 | 1.04 | 0.83 | - |  | 
 | Unmutated IGHV | 2.46 | <0.0001 | 2.04 | 0.0008 | 2.04 | 0.0003 | 
 | del17p | 3.44 | <0.0001 | 2.14 | 0.0015 | 2.06 | 0.0022 | 
 | del11q | 1.39 | 0.248 | ND |  |  |  | 
 | Year of diagnosis |  | 0.0130 | <COLSPAN=2> (in model as strata)* | <COLSPAN=2> (in model as strata)* | 
 | <2001 | ref |  |  |  |  |  | 
 | 2001-2005 | 1.46 |  |  |  |  |  | 
 | >2005 | 2.34 |  |  |  |  |  | 
 | Therapy |  | 0.106 | ND |  |  |  | 
 | Chemotherapy | ref |  |  |  |  |  | 
 | Immunochemotherapy | 0.6 |  |  |  |  |  |