Crohn's disease
Table:
Crohn's disease
Other names	Crohn syndrome, regional enteritis, Leśniowski-Crohn's disease

The three most common sites of intestinal involvement in Crohn's disease.
Specialty	Gastroenterology
Symptoms	Abdominal pain, diarrhea (may be bloody), fever, weight loss[1]
Complications	Anemia, skin rashes, arthritis, bowel cancer[1]
Usual onset	20 to 30[2]
Duration	Long term[1]
Risk factors	Tobacco smoking[3]
Diagnostic method	Biopsy, medical imaging[1]
Differential diagnosis	Irritable bowel syndrome, celiac disease, Behçet's disease, nonsteroidal anti-inflammatory drug enteropathy, intestinal tuberculosis[1][4]
Medication	Corticosteroids, methotrexate[1]
Prognosis	Slightly reduced life expectancy[1]
Frequency	3.2 per 1,000 (developed world)[5]

Using the given table, assess whether the statement is entailed, neutral, or refuted. Give your final answer in JSON format {"answer": "YOUR ANSWER"}.

Statement: Crohn's disease has shown increased frequency over the years.

answer: neutral