spinocerebellar ataxia
classification
Table:
SCA Type

Average Onset
(Range in Years)

Average Duration
(Range in Years)

What the patient experiences

Common origin

Problems
with DNA

SCA1[4] (ATXN1)

4th decade
(<10 to >60)

15 years
(10–35)

Hypermetric saccades, slow saccades, upper motor neuron
(note: saccades relates to eye movement)

CAG repeat, 6p (Ataxin 1)

SCA2[5] (ATXN2)

3rd–4th decade
(<10 to >60)

10 years
(1–30)

Diminished velocity saccades
areflexia (absence of neurologic reflexes)

Cuba

CAG repeat, 12q

SCA3[6] (MJD) (ATXN3)

4th decade
(10–70)

10 years
(1–20)

Also called Machado-Joseph disease (MJD)[7]
Gaze-evoked nystagmus (a rapid, involuntary, oscillatory motion of the eyeball)
upper motor neuron
slow saccades

Azores
(Portugal)

CAG repeat, 14q

SCA4 (PLEKHG4)

4th–7th decade
(19–72)

Decades

areflexia (absence of neurologic reflexes)

Chromosome 16q

SCA5 (SPTBN2)

3rd–4th decade
(10–68)

>25 years

Pure cerebellar

Chromosome 11

SCA6[8] (CACNA1A)

5th–6th decade
(19–71)

>25 years

Downbeating nystagmus, positional vertigo
Symptoms can appear for the first time as late as 65 years old.

CAG repeat, 19p
Calcium channel gene

SCA7[9] (ATXN7)

3rd–4th decade
(0.5–60)

20 years
(1–45; early onset correlates with shorter duration)

Macular degeneration, upper motor neuron, slow saccades

CAG repeat, 3p (Ataxin 7)

SCA8[10] (IOSCA)

39 yrs
(18–65)

Normal lifespan

Horizontal nystagmus (a rapid, involuntary, oscillatory motion of the eyeball), instability, lack of coordination

CTG repeat,[11] 13q

SCA10[12] (ATXN10)

36 years

9 years

ataxia, seizures

Mexico

Chromosome 22q linked
pentanucleotide repeat

SCA11

30 yrs
(15–70)

Normal lifespan

Mild, remain ambulatory (able to walk about on one's own)

15q

SCA12[13] (PPP2R2B)

33 yrs
(8–55)

Head and hand tremor,
akinesia (loss of normal motor function, resulting in impaired muscle movement)

CAG repeat, 5q

SCA13

Childhood or adulthood depending on mutation

Depending on KCNC3 (a kind of gene)

Mental retardation

19q

SCA14[14] (PRKCG)

28 yrs
(12–42)

Decades
(1–30)

Myoclonus (a sudden twitching of muscles or parts of muscles, without any rhythm or pattern, occurring in various brain disorders)

19q

SCA16

39 yrs
(20–66)

1–40 years

Head and hand tremor

8q

SCA17 (TBP)

CAG repeat, 6q (TATA-binding protein)

SCA19, SCA22

Mild cerebellar syndrome, dysarthria

SCA25

1.5–39 yrs

Unknown

ataxia with sensory neuropathy, vomiting and gastrointestinal pain.

2p

SCA27[15]

15–20 yrs

Unknown

ataxia with low cognition, dyskinesias and tremor.

FGF14 13q34

For the Wikipedia table from the article 'spinocerebellar ataxia' (section 'classification') on Wikipedia, pick the right types for the highlighted column from the following candidates: broadcast.radio_format, architecture.building, tv.tv_series_season, astronomy.constellation, travel.accommodation, music.composition, sports.sports_championship, award.recurring_competition, location.region, people.family_member, comic_books.comic_book_character, chess.chess_player, meteorology.tropical_cyclone, book.author, geography.island, medicine.drug, chemistry.chemical_element, cvg.cvg_developer, olympics.olympic_games, american_football.football_team, business.industry, tennis.tennis_tournament, book.periodical, theater.play, time.recurring_event, tennis.tennis_tournament_champion, sports.sports_league_season, music.media_format, soccer.football_award, award.award_presenting_organization, government.governmental_body, business.consumer_company, tv.tv_network, american_football.football_player, music.performance_role, book.book, aviation.airline, automotive.company, architecture.structure, government.politician, sports.cyclist, food.food, amusement_parks.park, music.group_member, music.album, music.genre, medicine.disease, film.film_distributor, american_football.football_coach, business.defunct_company, basketball.basketball_team, film.film_festival_focus, government.legislative_session, soccer.football_team_manager, film.production_company, music.artist, soccer.football_league, sports.professional_sports_team, tv.tv_actor, business.brand, architecture.architectural_structure_owner, location.uk_statistical_location, military.military_person, celebrities.celebrity, cricket.cricket_bowler, sports.school_sports_team, ice_hockey.hockey_team, award.hall_of_fame_inductee, aviation.aircraft_owner, biology.organism_classification, education.educational_institution, language.human_language, tv.tv_genre, rail.locomotive_class, film.actor, education.university, sports.sports_award_winner, soccer.football_position, broadcast.artist, education.field_of_study, sports.multi_event_tournament, metropolitan_transit.transit_stop, soccer.football_player, religion.religion, location.province, olympics.olympic_event_competition, location.in_district, location.capital_of_administrative_division, royalty.monarch, boats.ship_class, metropolitan_transit.transit_line, business.job_title, amusement_parks.ride, award.award_discipline, sports.sports_league, location.australian_local_government_area, military.rank, soccer.football_team, biology.animal, sports.sports_position, music.record_label, architecture.venue, media_common.media_genre, boats.ship, military.armed_force, organization.organization, time.event, award.award_category, military.military_post, people.ethnicity, computer.software, sports.sports_championship_event, award.award, astronomy.star_system_body, cricket.cricket_team, government.general_election, meteorology.tropical_cyclone_season, royalty.noble_title, automotive.model, location.citytown, sports.golfer, music.musical_scale, fictional_universe.fictional_organization, education.athletics_brand, theater.theater_actor, cricket.cricket_stadium, organization.non_profit_organization, interests.collection_category, astronomy.orbital_relationship, education.fraternity_sorority, aviation.airport, business.consumer_product, spaceflight.astronaut, tv.tv_writer, baseball.baseball_player, royalty.noble_person, biology.organism, sports.sports_league_draft, soccer.fifa, baseball.baseball_position, government.u_s_congressperson, business.product_category, business.business_operation, law.legal_case, geography.river, award.competition, broadcast.tv_station, film.film_character, location.us_county, cvg.computer_videogame, music.writer, military.military_conflict, book.magazine, organization.membership_organization, astronomy.astronomical_discovery, broadcast.radio_station, cvg.cvg_genre, aviation.aircraft_model, soccer.football_world_cup, sports.sports_team, law.court, education.educational_degree, computer.computer, location.administrative_division, internet.website_owner, tv.tv_personality, medicine.anatomical_structure, visual_art.visual_artist, cvg.cvg_platform, music.lyricist, location.in_state, geography.body_of_water, location.hud_county_place, protected_sites.listed_site, music.music_video_director, sports.sport, astronomy.celestial_object, government.government_agency, transportation.road, film.director, sports.pro_athlete, book.written_work, chemistry.chemical_compound, film.writer, music.musical_group, religion.religious_leader, tennis.tennis_player, location.location, book.periodical_publisher, basketball.basketball_coach, broadcast.tv_channel, location.australian_state, book.periodical_subject, sports.tournament_event_competition, medicine.medical_treatment, sports.sports_facility, tv.tv_series_episode, film.film_genre, government.election, royalty.chivalric_order_member, music.producer, basketball.basketball_position, boats.ship_type, award.award_ceremony, baseball.baseball_league, people.person, location.uk_constituent_country, royalty.kingdom, basketball.basketball_conference, law.invention, film.film, business.customer, location.country, government.political_party, location.jp_prefecture, baseball.baseball_team, astronomy.asteroid, cricket.cricket_player, sports.boxer, basketball.basketball_player, soccer.football_league_season, music.composer, military.military_unit, medicine.drug_ingredient, government.election_campaign, tv.tv_program, music.instrument, computer.software_license, exhibitions.exhibition_sponsor, location.us_state, tv.tv_character, american_football.football_conference, ice_hockey.hockey_player, martial_arts.martial_artist, tv.tv_director, metropolitan_transit.transit_system, ice_hockey.hockey_position, medicine.muscle, book.newspaper, computer.operating_system, film.music_contributor, broadcast.broadcast, finance.currency, geography.mountain, tv.tv_producer, fictional_universe.fictional_character, sports.sports_award_type, government.government_office_or_title, cvg.cvg_publisher, education.school, internet.website, film.producer, tv.tv_program_creator, government.us_president, broadcast.genre. Return the selected type name(s) only, comma-separated when necessary, in the list of this JSON object {"answer": ["ANSWER"]}.

{"answer": ["location.location"]}