and many congenital heart diseases are also commonly found in the Great Dane, leading to its nickname: the heartbreak breed, in conjunction with its shorter lifespan. Great Danes also may carry the merle gene, which is part of the genetic makeup that creates the harlequin coloring. The merle gene is an incomplete dominant, meaning only one copy of the gene is needed to show the merle coloring; two merle genes produce excessive white markings and many health issues such as deafness, blindness, or other debilitating ocular issues. Great Danes can also develop wobbler disease, a condition affecting the vertebral column. Since these dogs do grow at a rapid rate, the bones in their vertebae can push up against the spinal cord and cause weakness in the legs. This can be treated with surgery or may heal itself over time. Their average lifespan is 6 to 8 years; however, some Great Danes have been known to reach 10 years of age or more. Like many larger breeds, Great Danes are at particular risk for hip dysplasia.
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