The breed can also be affected by sebaceous adenitis, an uncommon idiopathic autoimmune skin disease. If a carrier female is mated with a healthy stud dog, the female offspring have a 50% chance of being carriers for the disease, and any male offspring have a 50% chance of being affected by the disease. A genetic test is available for this disease. Life expectancy for the breed is about 12–13 years. The breed can be affected by a genetic disease known as Samoyed hereditary glomerulopathy, a kidney disease. The disease is known to be caused by an X-linked dominant faulty allele and therefore the disease is more severe in male Samoyeds. Also known as hereditary nephritis, it is caused by a nonsense mutation in codon 1027 of the COL4A5 gene on the X chromosome (glycine to stop codon), which is similar to Alport's syndrome in humans.
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