The breed can also be affected by sebaceous adenitis, an uncommon idiopathic autoimmune skin disease. The breed can be affected by a genetic disease known as Samoyed hereditary glomerulopathy, a kidney disease. The disease is known to be caused by an X-linked dominant faulty allele and therefore the disease is more severe in male Samoyeds. Also known as hereditary nephritis, it is caused by a nonsense mutation in codon 1027 of the COL4A5 gene on the X chromosome (glycine to stop codon), which is similar to Alport's syndrome in humans. Short legs in conjunction with eye abnormalities: Due to a genetic defect at the COL2A1 locus occurs on disproportionate dwarfism with short limbs in connection with cataracts, malformations of the retina and / or retinal detachment, liquefaction of the vitreous and a persistent hyaloid artery. The malformations of the retina are dominant (i.e. before coming in heterozygous dogs); the other symptoms are recessive, so they only come to expression in homozygous affected dogs. A connection with Opticin is not.
[{"common_diseases": "sebaceous adenitis", "affects_eyes": "no", "caused_by_genetics": "yes"}, {"common_diseases": "Samoyed hereditary glomerulopathy, ", "affects_eyes": "no", "caused_by_genetics": "yes"}]
[{"common_diseases": "sebaceous adenitis", "affects_eyes": "no", "caused_by_genetics": "yes"}, {"common_diseases": "Samoyed hereditary glomerulopathy, ", "affects_eyes": "no", "caused_by_genetics": "yes"}]