The Border Collie is a working and herding dog breed developed in the Scottish borders for herding livestock, especially sheep. It was specifically bred for intelligence and obedience. It is very fetch-oriented. It is very fetch-oriented. In nearly every region of the world, the border collie is now also a breed that is shown in ring or bench shows. For the people who participate in these events, the Border Collie is defined by the breed standard, which is a description of how the dog should look. Trapped Neutrophil Syndrome (TNS) is a hereditary disease in which the bone marrow produces neutrophils (white cells) but is unable to effectively release them into the bloodstream. Affected puppies have an impaired immune system and will eventually die from infections they cannot fight. The mutation responsible for TNS has been found in border collies in English working dogs, in show dogs that had originated in Australia and New Zealand, and in unrelated Australian working dogs.