After his college graduation in 1852, Harrison studied law with Judge Bellamy Storer of Cincinnati, but before he completed his studies, he returned to Oxford, Ohio, to marry Caroline Scott on October 20, 1853. Caroline's father, a Presbyterian minister, performed the ceremony. The Harrisons had two children, Russell Benjamin Harrison (August 12, 1854 – December 13, 1936) and Mary 'Mamie' Scott Harrison (April 3, 1858 – October 28, 1930).