The Upper Muley Twist Canyon Road is located one mile (1.6 km) west of the top of the Burr Trail Road switchbacks. Passenger cars can usually be driven about 0.3 mile (0.5 km) in to the Upper Muley Twist Canyon trailhead. High-clearance vehicles, typically requiring four-wheel drive, can drive 2.9 miles (4.7 km) up the canyon to the Strike Valley Overlook parking area.