Background: The primary role of red blood cells in the circulatory system is to transport oxygen to the tissues. The actual carrier of oxygen molecules is the protein hemoglobin, which binds to the oxygen and moves it throughout the body, releasing it in areas where the concentration of dissolved oxygen is low. A certain mutation in the gene for hemoglobin causes a slight change in the structure of this crucial protein, resulting in a disease called sickle-cell anemia. For people with this mutation, the hemoglobin produced by their red blood cells has a tendency to clump together, distorting the shape of the red blood cells and giving rise to the crescent-shaped cells seen above. By understanding the changes in structure that are the underlying cause of this disease, we have developed various ways to treat and manage this illness.

Situation: Dan had two children: Karen which had sickle-cell anemia, and his son Bob, which was healthy.

Question: Which child had a mutated hemoglobin?
Answer: Karen

Situation: Dan had two children: Karen which had sickle-cell anemia, and his son Bob, which was healthy.

Question: Which child didn't have a mutated hemoglobin?
Answer: Bob

Situation: Dan had two children: Karen which had sickle-cell anemia, and his son Bob, which was healthy.

Question: Which child has a hemoglobin that clumps together?
Answer: Karen

Situation: Dan had two children: Karen which had sickle-cell anemia, and his son Bob, which was healthy.

Question: Which child doesn't have a hemoglobin that clumps together?
Answer: Bob

Situation: Dan had two children: Karen which had sickle-cell anemia, and his son Bob, which was healthy.

Question: Which child doesn't have a hemoglobin that gives rise to the crescent-shaped cells?
Answer: Bob

Situation: Dan had two children: Karen which had sickle-cell anemia, and his son Bob, which was healthy.

Question: Which child has a hemoglobin that gives rise to the crescent-shaped cells?
Answer: Karen

Situation: Dan had two children: Karen which had sickle-cell anemia, and his son Bob, which was healthy.

Question: Which child has a crucial protein that presents a mutation?
Answer: Karen

Situation: Dan had two children: Karen which had sickle-cell anemia, and his son Bob, which was healthy.

Question: Which child doesn't have a crucial protein that presents a mutation?
Answer: Bob

Situation: Dan had two children: Karen which had sickle-cell anemia, and his son Bob, which was healthy.

Question: Which child doesn't have a disease that causes anemia?
Answer: Bob

Situation: Dan had two children: Karen which had sickle-cell anemia, and his son Bob, which was healthy.

Question: Which child has a disease that causes anemia?
Answer: Karen

Situation: Doctors studied Dan, a normal patient, whit a normal number of red blood cells, and Jim, a patient that had sickle-cell anemia. The differences were remarkable in terms of overall well-being and health.

Question: Which patient had more red blood cells, Dan or Jim?
Answer: Dan

Situation: Doctors studied Dan, a normal patient, whit a normal number of red blood cells, and Jim, a patient that had sickle-cell anemia. The differences were remarkable in terms of overall well-being and health.

Question: Which patient had fewer red blood cells, Dan or Jim?
Answer: Jim

Situation: Doctors studied Dan, a normal patient, whit a normal number of red blood cells, and Jim, a patient that had sickle-cell anemia. The differences were remarkable in terms of overall well-being and health.

Question: Which patient had more clumped together hemoglobin, Dan or Jim?
Answer: Jim

Situation: Doctors studied Dan, a normal patient, whit a normal number of red blood cells, and Jim, a patient that had sickle-cell anemia. The differences were remarkable in terms of overall well-being and health.

Question: Which patient had less clumped together hemoglobin, Dan or Jim?
Answer: Dan

Situation: Doctors studied Dan, a normal patient, whit a normal number of red blood cells, and Jim, a patient that had sickle-cell anemia. The differences were remarkable in terms of overall well-being and health.

Question: Which patient had less hemoglobin destroying the shape of the red blood cells, Dan or Jim?
Answer: Dan

Situation: Doctors studied Dan, a normal patient, whit a normal number of red blood cells, and Jim, a patient that had sickle-cell anemia. The differences were remarkable in terms of overall well-being and health.

Question: Which patient had more hemoglobin destroying the shape of the red blood cells, Dan or Jim?
Answer: Jim

Situation: Doctors studied Dan, a normal patient, whit a normal number of red blood cells, and Jim, a patient that had sickle-cell anemia. The differences were remarkable in terms of overall well-being and health.

Question: Which patient had more crescent shaped red blood cells, Dan or Jim?
Answer: Jim

Situation: Doctors studied Dan, a normal patient, whit a normal number of red blood cells, and Jim, a patient that had sickle-cell anemia. The differences were remarkable in terms of overall well-being and health.

Question: Which patient had fewer crescent shaped red blood cells, Dan or Jim?
Answer: Dan

Situation: Doctors studied Dan, a normal patient, whit a normal number of red blood cells, and Jim, a patient that had sickle-cell anemia. The differences were remarkable in terms of overall well-being and health.

Question: Which patient had fewer normal shaped red blood cells, Dan or Jim?
Answer: Jim

Situation: Doctors studied Dan, a normal patient, whit a normal number of red blood cells, and Jim, a patient that had sickle-cell anemia. The differences were remarkable in terms of overall well-being and health.

Question: Which patient had more normal shaped red blood cells, Dan or Jim?
Answer: Dan

Situation: Dr. Bill studies 2 groups of patients, group S composed of individuals with siclke-cell anemia, and group N with normal blood and no health issues.

Question: Which group had people with more crescent-shaped cells?
Answer: group S

Situation: Dr. Bill studies 2 groups of patients, group S composed of individuals with siclke-cell anemia, and group N with normal blood and no health issues.

Question: Which group had people with fewer crescent-shaped cells?
Answer: group N

Situation: Dr. Bill studies 2 groups of patients, group S composed of individuals with siclke-cell anemia, and group N with normal blood and no health issues.

Question: Which group had people with fewer changes in cellular structure?
Answer: group N

Situation: Dr. Bill studies 2 groups of patients, group S composed of individuals with siclke-cell anemia, and group N with normal blood and no health issues.

Question: Which group had people with more changes in cellular structure?
Answer: group S

Situation: Dr. Bill studies 2 groups of patients, group S composed of individuals with siclke-cell anemia, and group N with normal blood and no health issues.

Question: Which group had people with more cells distorted by hemoglobin?
Answer: group S

Situation: Dr. Bill studies 2 groups of patients, group S composed of individuals with siclke-cell anemia, and group N with normal blood and no health issues.

Question: Which group had people with fewer cells distorted by hemoglobin?
Answer: group N

Situation: Dr. Bill studies 2 groups of patients, group S composed of individuals with siclke-cell anemia, and group N with normal blood and no health issues.

Question: Which group had people with less hemoglobin clumping together?
Answer: group N

Situation: Dr. Bill studies 2 groups of patients, group S composed of individuals with siclke-cell anemia, and group N with normal blood and no health issues.

Question: Which group had people with more hemoglobin clumping together?
Answer: group S

Situation: Dr. Bill studies 2 groups of patients, group S composed of individuals with siclke-cell anemia, and group N with normal blood and no health issues.

Question: Which group had people with a certain gene mutation?
Answer: group S

Situation: Dr. Bill studies 2 groups of patients, group S composed of individuals with siclke-cell anemia, and group N with normal blood and no health issues.

Question: Which group didn't have people with a certain gene mutation?
Answer: group N

Situation: Doctor Jones studied two teams of workers. Team one had healthy people with normal red blood cell levels, but team two had people with sickle-cell anemia. the differences in health parameters were amazing and obvious.

Question: Which team had people getting less oxygen to their cells?
Answer: team two

Situation: Doctor Jones studied two teams of workers. Team one had healthy people with normal red blood cell levels, but team two had people with sickle-cell anemia. the differences in health parameters were amazing and obvious.

Question: Which team had people getting more oxygen to their cells?
Answer: Team one

Situation: Doctor Jones studied two teams of workers. Team one had healthy people with normal red blood cell levels, but team two had people with sickle-cell anemia. the differences in health parameters were amazing and obvious.

Question: Which team had people with mutated hemoglobin?
Answer: team two

Situation: Doctor Jones studied two teams of workers. Team one had healthy people with normal red blood cell levels, but team two had people with sickle-cell anemia. the differences in health parameters were amazing and obvious.

Question: Which team had people with normal hemoglobin?
Answer: Team one

Situation: Doctor Jones studied two teams of workers. Team one had healthy people with normal red blood cell levels, but team two had people with sickle-cell anemia. the differences in health parameters were amazing and obvious.

Question: Which team had people with their hemoglobin clumping together?
Answer: team two

Situation: Doctor Jones studied two teams of workers. Team one had healthy people with normal red blood cell levels, but team two had people with sickle-cell anemia. the differences in health parameters were amazing and obvious.

Question: Which team didn't have people with their hemoglobin clumping together?
Answer: Team one

Situation: Doctor Jones studied two teams of workers. Team one had healthy people with normal red blood cell levels, but team two had people with sickle-cell anemia. the differences in health parameters were amazing and obvious.

Question: Which team didn't have people with crescent shaped cells in their blood?
Answer: Team one

Situation: Doctor Jones studied two teams of workers. Team one had healthy people with normal red blood cell levels, but team two had people with sickle-cell anemia. the differences in health parameters were amazing and obvious.

Question: Which team had people with crescent shaped cells in their blood?
Answer: team two

Situation: Doctor Jones studied two teams of workers. Team one had healthy people with normal red blood cell levels, but team two had people with sickle-cell anemia. the differences in health parameters were amazing and obvious.

Question: Which team had people with distorted red blood cells?
Answer: team two

Situation: Doctor Jones studied two teams of workers. Team one had healthy people with normal red blood cell levels, but team two had people with sickle-cell anemia. the differences in health parameters were amazing and obvious.

Question: Which team had no people with distorted red blood cells?
Answer: Team one