Background: Some individuals have a specific mutation in the primary sequence of their hemoglobin molecules that causes them to aggregate, resulting in a deformation of their red blood cells. This abnormality is genetic in nature. A person may inherit the gene from one parent and have sickle cell trait (only some of the hemoglobin is hemoglobin S), which is usually not life-threatening. Inheriting the gene from both parents will result in sickle cell disease, which is a very serious condition.

Situation: Pete and Mike were two brothers. Pete had no health problems, while Mike inherited the sickle cell trait. Mike had adjacent health problems.

Question: Which brother had a specific mutation in the primary sequence of his hemoglobin molecules?
Answer: Mike

Situation: Pete and Mike were two brothers. Pete had no health problems, while Mike inherited the sickle cell trait. Mike had adjacent health problems.

Question: Which brother didn't have a specific mutation in the primary sequence of his hemoglobin molecules?
Answer: Pete

Situation: Pete and Mike were two brothers. Pete had no health problems, while Mike inherited the sickle cell trait. Mike had adjacent health problems.

Question: Which brother had an abnormality that was genetic in nature?
Answer: Mike

Situation: Pete and Mike were two brothers. Pete had no health problems, while Mike inherited the sickle cell trait. Mike had adjacent health problems.

Question: Which brother didn't have  any abnormalities that were genetic in nature?
Answer: Pete

Situation: Pete and Mike were two brothers. Pete had no health problems, while Mike inherited the sickle cell trait. Mike had adjacent health problems.

Question: Which brother had molecules of hemoglobin that aggregate?
Answer: Mike

Situation: Pete and Mike were two brothers. Pete had no health problems, while Mike inherited the sickle cell trait. Mike had adjacent health problems.

Question: Which brother didn't have molecules of hemoglobin that aggregate?
Answer: Pete

Situation: Pete and Mike were two brothers. Pete had no health problems, while Mike inherited the sickle cell trait. Mike had adjacent health problems.

Question: Which brother inherited a genetic disease from one of his parents?
Answer: Mike

Situation: Pete and Mike were two brothers. Pete had no health problems, while Mike inherited the sickle cell trait. Mike had adjacent health problems.

Question: Which brother did not inherit a genetic disease from one of his parents?
Answer: Pete

Situation: Pete and Mike were two brothers. Pete had no health problems, while Mike inherited the sickle cell trait. Mike had adjacent health problems.

Question: Which brother had some hemoglobin S in his blood?
Answer: Mike

Situation: Pete and Mike were two brothers. Pete had no health problems, while Mike inherited the sickle cell trait. Mike had adjacent health problems.

Question: Which brother didn't have any hemoglobin S in his blood?
Answer: Pete

Situation: Dan studied two groups of individuals. Group S that had sickle cell anemia, and group B which had normal hemoglobin. He was fascinated by the results.

Question: Which group had a specific mutation in the primary sequence of their hemoglobin molecules?
Answer: Group S

Situation: Dan studied two groups of individuals. Group S that had sickle cell anemia, and group B which had normal hemoglobin. He was fascinated by the results.

Question: Which group didn't have a specific mutation in the primary sequence of their hemoglobin molecules?
Answer: group B

Situation: Dan studied two groups of individuals. Group S that had sickle cell anemia, and group B which had normal hemoglobin. He was fascinated by the results.

Question: Which group didn't have aggregating hemoglobin?
Answer: group B

Situation: Dan studied two groups of individuals. Group S that had sickle cell anemia, and group B which had normal hemoglobin. He was fascinated by the results.

Question: Which group had aggregating hemoglobin?
Answer: Group S

Situation: Dan studied two groups of individuals. Group S that had sickle cell anemia, and group B which had normal hemoglobin. He was fascinated by the results.

Question: Which group had more deformed blood cells?
Answer: Group S

Situation: Dan studied two groups of individuals. Group S that had sickle cell anemia, and group B which had normal hemoglobin. He was fascinated by the results.

Question: Which group had fewer deformed blood cells?
Answer: group B

Situation: Dan studied two groups of individuals. Group S that had sickle cell anemia, and group B which had normal hemoglobin. He was fascinated by the results.

Question: Which group had more members that may inherit the gene from one parent and have sickle cell trait?
Answer: Group S

Situation: Dan studied two groups of individuals. Group S that had sickle cell anemia, and group B which had normal hemoglobin. He was fascinated by the results.

Question: Which group had fewer members that may inherit the gene from one parent and have sickle cell trait?
Answer: group B

Situation: Dan studied two groups of individuals. Group S that had sickle cell anemia, and group B which had normal hemoglobin. He was fascinated by the results.

Question: Which group had fewer members that had hemoglobin S?
Answer: group B

Situation: Dan studied two groups of individuals. Group S that had sickle cell anemia, and group B which had normal hemoglobin. He was fascinated by the results.

Question: Which group had more members that had hemoglobin S?
Answer: Group S

Situation: Barb and Ann were friends. The used to play together outside in the yard till one day Barb's parents found out that she had sickle cell anemia. They haven't played together since.

Question: Which girl had a specific mutation in the primary sequence of their hemoglobin molecules?
Answer: Barb

Situation: Barb and Ann were friends. The used to play together outside in the yard till one day Barb's parents found out that she had sickle cell anemia. They haven't played together since.

Question: Which girl didn't have a mutation in the primary sequence of their hemoglobin molecules?
Answer: Ann

Situation: Barb and Ann were friends. The used to play together outside in the yard till one day Barb's parents found out that she had sickle cell anemia. They haven't played together since.

Question: Which girl had a deformation of her red blood cells?
Answer: Barb

Situation: Barb and Ann were friends. The used to play together outside in the yard till one day Barb's parents found out that she had sickle cell anemia. They haven't played together since.

Question: Which girl didn't have a deformation of her red blood cells?
Answer: Ann

Situation: Barb and Ann were friends. The used to play together outside in the yard till one day Barb's parents found out that she had sickle cell anemia. They haven't played together since.

Question: Which girl presented a genetic abnormality?
Answer: Barb

Situation: Barb and Ann were friends. The used to play together outside in the yard till one day Barb's parents found out that she had sickle cell anemia. They haven't played together since.

Question: Which girl didn't present a genetic abnormality?
Answer: Ann

Situation: Barb and Ann were friends. The used to play together outside in the yard till one day Barb's parents found out that she had sickle cell anemia. They haven't played together since.

Question: Which girl had hemoglobin S in her blood?
Answer: Barb

Situation: Barb and Ann were friends. The used to play together outside in the yard till one day Barb's parents found out that she had sickle cell anemia. They haven't played together since.

Question: Which girl didn't have hemoglobin S in her blood?
Answer: Ann

Situation: Barb and Ann were friends. The used to play together outside in the yard till one day Barb's parents found out that she had sickle cell anemia. They haven't played together since.

Question: Which girl had a life threatening disease?
Answer: Barb

Situation: Barb and Ann were friends. The used to play together outside in the yard till one day Barb's parents found out that she had sickle cell anemia. They haven't played together since.

Question: Which of the girls didn't have a life threatening disease?
Answer: Ann

Situation: Doctors studied two groups of patients. Group W which had people with sickle cell disease, and group A which had normal people in it.

Question: Which group had more individuals with a specific mutation in the primary sequence of their hemoglobin molecules?
Answer: Group W

Situation: Doctors studied two groups of patients. Group W which had people with sickle cell disease, and group A which had normal people in it.

Question: Which group had fewer individuals with a specific mutation in the primary sequence of their hemoglobin molecules?
Answer: group A

Situation: Doctors studied two groups of patients. Group W which had people with sickle cell disease, and group A which had normal people in it.

Question: Which group had fewer individuals with aggregating hemoglobin?
Answer: group A

Situation: Doctors studied two groups of patients. Group W which had people with sickle cell disease, and group A which had normal people in it.

Question: Which group had more individuals with aggregating hemoglobin?
Answer: Group W

Situation: Doctors studied two groups of patients. Group W which had people with sickle cell disease, and group A which had normal people in it.

Question: Which group had more individuals with deformed blood cells?
Answer: Group W

Situation: Doctors studied two groups of patients. Group W which had people with sickle cell disease, and group A which had normal people in it.

Question: Which group had fewer individuals with deformed blood cells?
Answer: group A

Situation: Doctors studied two groups of patients. Group W which had people with sickle cell disease, and group A which had normal people in it.

Question: Which group had fewer individuals with genetic abnormalities?
Answer: group A

Situation: Doctors studied two groups of patients. Group W which had people with sickle cell disease, and group A which had normal people in it.

Question: Which group had more individuals with genetic abnormalities?
Answer: Group W

Situation: Doctors studied two groups of patients. Group W which had people with sickle cell disease, and group A which had normal people in it.

Question: Which group had more individuals inheriting the gene from both parents ?
Answer: Group W

Situation: Doctors studied two groups of patients. Group W which had people with sickle cell disease, and group A which had normal people in it.

Question: Which group had fewer individuals inheriting the gene from both parents ?
Answer: group A

Situation: Two sisters went to the hospital. The medics ran some blood tests and found out that Sue had sickle cell trait, while Mary had normal blood cells. Sue received treatment.

Question: Which sister has a specific mutation in the primary sequence of their hemoglobin molecules?
Answer: Sue

Situation: Two sisters went to the hospital. The medics ran some blood tests and found out that Sue had sickle cell trait, while Mary had normal blood cells. Sue received treatment.

Question: Which sister does not have a specific mutation in the primary sequence of their hemoglobin molecules?
Answer: Mary

Situation: Two sisters went to the hospital. The medics ran some blood tests and found out that Sue had sickle cell trait, while Mary had normal blood cells. Sue received treatment.

Question: Which sister does not have hemoglobin molecules that aggregate?
Answer: Mary

Situation: Two sisters went to the hospital. The medics ran some blood tests and found out that Sue had sickle cell trait, while Mary had normal blood cells. Sue received treatment.

Question: Which sister has hemoglobin molecules that aggregate?
Answer: Sue

Situation: Two sisters went to the hospital. The medics ran some blood tests and found out that Sue had sickle cell trait, while Mary had normal blood cells. Sue received treatment.

Question: Which sister has a deformation of her red blood cells?
Answer: Sue

Situation: Two sisters went to the hospital. The medics ran some blood tests and found out that Sue had sickle cell trait, while Mary had normal blood cells. Sue received treatment.

Question: Which sister doesn't have a deformation of her red blood cells?
Answer: Mary

Situation: Two sisters went to the hospital. The medics ran some blood tests and found out that Sue had sickle cell trait, while Mary had normal blood cells. Sue received treatment.

Question: Which sister doesn't have a genetic abnormality?
Answer: Mary

Situation: Two sisters went to the hospital. The medics ran some blood tests and found out that Sue had sickle cell trait, while Mary had normal blood cells. Sue received treatment.

Question: Which sister has a genetic abnormality?
Answer: Sue

Situation: Two sisters went to the hospital. The medics ran some blood tests and found out that Sue had sickle cell trait, while Mary had normal blood cells. Sue received treatment.

Question: Which sister has hemoglobin S in her blood?
Answer: Sue

Situation: Two sisters went to the hospital. The medics ran some blood tests and found out that Sue had sickle cell trait, while Mary had normal blood cells. Sue received treatment.

Question: Which sister doesn't have hemoglobin S in her blood?
Answer: Mary