Background: Cholesterol has been implicated in heart disease for decades. Atherosclerosis is a disorder of the arteries in which cholesterol and other materials are deposited on the interior of the arterial wall. These deposits lead to the formation of plaques that can restrict or even block the flow of blood through these blood vessels (see Figure below ). A decrease in the flow of blood can lead to high blood pressure and a lowered oxygen supply to the heart muscle. A complete blockage of blood flow to parts of the heart (a heart attack) can cause significant damage due to oxygen deprivation, in some cases leading to death.

Situation: Two brothers went to the doctor's office for an appointment. The doctor discovered that Tim had very high levels of cholesterol, while Jim had normal levels.

Question: Which brother was more at risk for developing atherosclerosis?
Answer: Tim

Situation: Two brothers went to the doctor's office for an appointment. The doctor discovered that Tim had very high levels of cholesterol, while Jim had normal levels.

Question: Which brother was less at risk for developing atherosclerosis?
Answer: Jim

Situation: Two brothers went to the doctor's office for an appointment. The doctor discovered that Tim had very high levels of cholesterol, while Jim had normal levels.

Question: Which brother had more plaques that can restrict blood flow?
Answer: Tim

Situation: Two brothers went to the doctor's office for an appointment. The doctor discovered that Tim had very high levels of cholesterol, while Jim had normal levels.

Question: Which brother had fewer plaques that can restrict blood flow?
Answer: Jim

Situation: Two brothers went to the doctor's office for an appointment. The doctor discovered that Tim had very high levels of cholesterol, while Jim had normal levels.

Question: Which brother had less cholesterol deposited on the interior of the arterial wall?
Answer: Jim

Situation: Two brothers went to the doctor's office for an appointment. The doctor discovered that Tim had very high levels of cholesterol, while Jim had normal levels.

Question: Which brother had more cholesterol deposited on the interior of the arterial wall?
Answer: Tim

Situation: Two brothers went to the doctor's office for an appointment. The doctor discovered that Tim had very high levels of cholesterol, while Jim had normal levels.

Question: Which brother experiences a decrease in blood flow?
Answer: Tim

Situation: Two brothers went to the doctor's office for an appointment. The doctor discovered that Tim had very high levels of cholesterol, while Jim had normal levels.

Question: Which brother doesn't experience a decrease in blood flow?
Answer: Jim

Situation: Two brothers went to the doctor's office for an appointment. The doctor discovered that Tim had very high levels of cholesterol, while Jim had normal levels.

Question: Which brother doesn't experience a lowered oxygen supply to the heart muscle?
Answer: Jim

Situation: Two brothers went to the doctor's office for an appointment. The doctor discovered that Tim had very high levels of cholesterol, while Jim had normal levels.

Question: Which brother experiences a lowered oxygen supply to the heart muscle?
Answer: Tim

Situation: Two teams of researchers studied different diseases. team Alpha studied people with cholesterol, while team Beta studied people with Parkinson's disease.

Question: Which team studied more people with atherosclerosis?
Answer: Alpha

Situation: Two teams of researchers studied different diseases. team Alpha studied people with cholesterol, while team Beta studied people with Parkinson's disease.

Question: Which team studied fewer people with atherosclerosis?
Answer: Beta

Situation: Two teams of researchers studied different diseases. team Alpha studied people with cholesterol, while team Beta studied people with Parkinson's disease.

Question: Which team studied fewer people with cholesterol and other materials deposited on the interior of the arterial wall?
Answer: Beta

Situation: Two teams of researchers studied different diseases. team Alpha studied people with cholesterol, while team Beta studied people with Parkinson's disease.

Question: Which team studied more people with cholesterol and other materials deposited on the interior of the arterial wall?
Answer: Alpha

Situation: Two teams of researchers studied different diseases. team Alpha studied people with cholesterol, while team Beta studied people with Parkinson's disease.

Question: Which team studied more people with plaques?
Answer: Alpha

Situation: Two teams of researchers studied different diseases. team Alpha studied people with cholesterol, while team Beta studied people with Parkinson's disease.

Question: Which team studied fewer people with plaques?
Answer: Beta

Situation: Two teams of researchers studied different diseases. team Alpha studied people with cholesterol, while team Beta studied people with Parkinson's disease.

Question: Which team studied fewer people with restricted blood flow to the heart muscle?
Answer: Beta

Situation: Two teams of researchers studied different diseases. team Alpha studied people with cholesterol, while team Beta studied people with Parkinson's disease.

Question: Which team studied more people with restricted blood flow to the heart muscle?
Answer: Alpha

Situation: Two teams of researchers studied different diseases. team Alpha studied people with cholesterol, while team Beta studied people with Parkinson's disease.

Question: Which team studied more people with high blood pressure?
Answer: Alpha

Situation: Two teams of researchers studied different diseases. team Alpha studied people with cholesterol, while team Beta studied people with Parkinson's disease.

Question: Which team studied fewer people with high blood pressure?
Answer: Beta

Situation: Brad and Dale went to the doctor for a check up. Brad did some blood tests and found out he has very high cholesterol levels, while his partner Dale had normal cholesterol levels, and was very healthy. Brad got scared and started worrying.

Question: Which friend was more at risk for heart disease?
Answer: Brad

Situation: Brad and Dale went to the doctor for a check up. Brad did some blood tests and found out he has very high cholesterol levels, while his partner Dale had normal cholesterol levels, and was very healthy. Brad got scared and started worrying.

Question: Which friend was less at risk for heart disease?
Answer: Dale

Situation: Brad and Dale went to the doctor for a check up. Brad did some blood tests and found out he has very high cholesterol levels, while his partner Dale had normal cholesterol levels, and was very healthy. Brad got scared and started worrying.

Question: Which friend was less at risk for atherosclerosis?
Answer: Dale

Situation: Brad and Dale went to the doctor for a check up. Brad did some blood tests and found out he has very high cholesterol levels, while his partner Dale had normal cholesterol levels, and was very healthy. Brad got scared and started worrying.

Question: Which friend was more at risk for atherosclerosis?
Answer: Brad

Situation: Brad and Dale went to the doctor for a check up. Brad did some blood tests and found out he has very high cholesterol levels, while his partner Dale had normal cholesterol levels, and was very healthy. Brad got scared and started worrying.

Question: Which friend had more plaque on his blood vessels?
Answer: Brad

Situation: Brad and Dale went to the doctor for a check up. Brad did some blood tests and found out he has very high cholesterol levels, while his partner Dale had normal cholesterol levels, and was very healthy. Brad got scared and started worrying.

Question: Which friend had less plaque on his blood vessels?
Answer: Dale

Situation: Brad and Dale went to the doctor for a check up. Brad did some blood tests and found out he has very high cholesterol levels, while his partner Dale had normal cholesterol levels, and was very healthy. Brad got scared and started worrying.

Question: Which friend had a decreased blood flow?
Answer: Brad

Situation: Brad and Dale went to the doctor for a check up. Brad did some blood tests and found out he has very high cholesterol levels, while his partner Dale had normal cholesterol levels, and was very healthy. Brad got scared and started worrying.

Question: Which friend didn't have a decreased blood flow?
Answer: Dale

Situation: Brad and Dale went to the doctor for a check up. Brad did some blood tests and found out he has very high cholesterol levels, while his partner Dale had normal cholesterol levels, and was very healthy. Brad got scared and started worrying.

Question: Which friend was at a higher risk of suffering a heart attack?
Answer: Brad

Situation: Brad and Dale went to the doctor for a check up. Brad did some blood tests and found out he has very high cholesterol levels, while his partner Dale had normal cholesterol levels, and was very healthy. Brad got scared and started worrying.

Question: Which friend was at a lower risk of suffering a heart attack?
Answer: Dale

Situation: Bob's parents were in their early 60's. He sent them to the doctor's for a routine check up. Dan, his dad, had very high cholesterol, while Mary, his mom , had normal levels in her blood.

Question: Which parent was at a higher risk of developing heart disease?
Answer: Dan

Situation: Bob's parents were in their early 60's. He sent them to the doctor's for a routine check up. Dan, his dad, had very high cholesterol, while Mary, his mom , had normal levels in her blood.

Question: Which parent was at a lower risk of developing heart disease?
Answer: Mary

Situation: Bob's parents were in their early 60's. He sent them to the doctor's for a routine check up. Dan, his dad, had very high cholesterol, while Mary, his mom , had normal levels in her blood.

Question: Which parent was at a lower risk of developing atherosclerosis?
Answer: Mary

Situation: Bob's parents were in their early 60's. He sent them to the doctor's for a routine check up. Dan, his dad, had very high cholesterol, while Mary, his mom , had normal levels in her blood.

Question: Which parent was at a higher risk of developing atherosclerosis?
Answer: Dan

Situation: Bob's parents were in their early 60's. He sent them to the doctor's for a routine check up. Dan, his dad, had very high cholesterol, while Mary, his mom , had normal levels in her blood.

Question: Which parent had more cholesterol deposits on the arterial wall?
Answer: Dan

Situation: Bob's parents were in their early 60's. He sent them to the doctor's for a routine check up. Dan, his dad, had very high cholesterol, while Mary, his mom , had normal levels in her blood.

Question: Which parent had fewer cholesterol deposits on the arterial wall?
Answer: Mary

Situation: Bob's parents were in their early 60's. He sent them to the doctor's for a routine check up. Dan, his dad, had very high cholesterol, while Mary, his mom , had normal levels in her blood.

Question: Which parent had fewer plaques that could restrict blood flow?
Answer: Mary

Situation: Bob's parents were in their early 60's. He sent them to the doctor's for a routine check up. Dan, his dad, had very high cholesterol, while Mary, his mom , had normal levels in her blood.

Question: Which parent had more plaques that could restrict blood flow?
Answer: Dan

Situation: Bob's parents were in their early 60's. He sent them to the doctor's for a routine check up. Dan, his dad, had very high cholesterol, while Mary, his mom , had normal levels in her blood.

Question: Which parent had more plaques that could potentially block blood flow?
Answer: Dan

Situation: Bob's parents were in their early 60's. He sent them to the doctor's for a routine check up. Dan, his dad, had very high cholesterol, while Mary, his mom , had normal levels in her blood.

Question: Which parent had fewer plaques that could potentially block blood flow?
Answer: Mary

Situation: Two brothers went to the doctor for their yearly examination. Liam found out he has high cholesterol, while Rudy found out his triglycerides and cholesterol are within normal parameters.

Question: Which brother was more at risk for heart disease?
Answer: Liam

Situation: Two brothers went to the doctor for their yearly examination. Liam found out he has high cholesterol, while Rudy found out his triglycerides and cholesterol are within normal parameters.

Question: Which brother was less at risk for heart disease?
Answer: Rudy

Situation: Two brothers went to the doctor for their yearly examination. Liam found out he has high cholesterol, while Rudy found out his triglycerides and cholesterol are within normal parameters.

Question: Which brother was less at risk for atherosclerosis?
Answer: Rudy

Situation: Two brothers went to the doctor for their yearly examination. Liam found out he has high cholesterol, while Rudy found out his triglycerides and cholesterol are within normal parameters.

Question: Which brother was more at risk for atherosclerosis?
Answer: Liam

Situation: Two brothers went to the doctor for their yearly examination. Liam found out he has high cholesterol, while Rudy found out his triglycerides and cholesterol are within normal parameters.

Question: Which brother was more at risk for plaques that can restrict or even block the flow of blood?
Answer: Liam

Situation: Two brothers went to the doctor for their yearly examination. Liam found out he has high cholesterol, while Rudy found out his triglycerides and cholesterol are within normal parameters.

Question: Which brother was less at risk for plaques that can restrict or even block the flow of blood?
Answer: Rudy

Situation: Two brothers went to the doctor for their yearly examination. Liam found out he has high cholesterol, while Rudy found out his triglycerides and cholesterol are within normal parameters.

Question: Which brother was less at risk for a heart attack?
Answer: Rudy

Situation: Two brothers went to the doctor for their yearly examination. Liam found out he has high cholesterol, while Rudy found out his triglycerides and cholesterol are within normal parameters.

Question: Which brother was more at risk for a heart attack?
Answer: Liam

Situation: Two brothers went to the doctor for their yearly examination. Liam found out he has high cholesterol, while Rudy found out his triglycerides and cholesterol are within normal parameters.

Question: Which brother was more at risk for death?
Answer: Liam

Situation: Two brothers went to the doctor for their yearly examination. Liam found out he has high cholesterol, while Rudy found out his triglycerides and cholesterol are within normal parameters.

Question: Which brother was less at risk for death?
Answer: Rudy

Situation: Two groups of patients were under observation for heart disease. The Red group was composed of people with low cholesterol, while the Yellow group was comprised of people with very high cholesterol.

Question: Which group had more people with atherosclerosis in it?
Answer: Yellow

Situation: Two groups of patients were under observation for heart disease. The Red group was composed of people with low cholesterol, while the Yellow group was comprised of people with very high cholesterol.

Question: Which group had fewer people with atherosclerosis in it?
Answer: Red

Situation: Two groups of patients were under observation for heart disease. The Red group was composed of people with low cholesterol, while the Yellow group was comprised of people with very high cholesterol.

Question: Which group had fewer people with plaques?
Answer: Red

Situation: Two groups of patients were under observation for heart disease. The Red group was composed of people with low cholesterol, while the Yellow group was comprised of people with very high cholesterol.

Question: Which group had more people with plaques?
Answer: Yellow

Situation: Two groups of patients were under observation for heart disease. The Red group was composed of people with low cholesterol, while the Yellow group was comprised of people with very high cholesterol.

Question: Which group had more people with decreased flow of blood?
Answer: Yellow

Situation: Two groups of patients were under observation for heart disease. The Red group was composed of people with low cholesterol, while the Yellow group was comprised of people with very high cholesterol.

Question: Which group had fewer people with decreased flow of blood?
Answer: Red

Situation: Two groups of patients were under observation for heart disease. The Red group was composed of people with low cholesterol, while the Yellow group was comprised of people with very high cholesterol.

Question: Which group had fewer people with high blood pressure?
Answer: Red

Situation: Two groups of patients were under observation for heart disease. The Red group was composed of people with low cholesterol, while the Yellow group was comprised of people with very high cholesterol.

Question: Which group had more people with high blood pressure?
Answer: Yellow

Situation: Two groups of patients were under observation for heart disease. The Red group was composed of people with low cholesterol, while the Yellow group was comprised of people with very high cholesterol.

Question: Which group had more people with lowered oxygen supply to the heart muscle?
Answer: Yellow

Situation: Two groups of patients were under observation for heart disease. The Red group was composed of people with low cholesterol, while the Yellow group was comprised of people with very high cholesterol.

Question: Which group had fewer people with lowered oxygen supply to the heart muscle?
Answer: Red

Situation: Fred was a good athlete in his youth, and so was Vic. Fred started eating junk food and other fatty foods in his 30's. His cholesterol is very high now. Vic became a vegan later,and he is in a very good physical shape.

Question: Which friend had a greater chance of developing heart disease?
Answer: Fred

Situation: Fred was a good athlete in his youth, and so was Vic. Fred started eating junk food and other fatty foods in his 30's. His cholesterol is very high now. Vic became a vegan later,and he is in a very good physical shape.

Question: Which friend had a smaller chance of developing heart disease?
Answer: Vic

Situation: Fred was a good athlete in his youth, and so was Vic. Fred started eating junk food and other fatty foods in his 30's. His cholesterol is very high now. Vic became a vegan later,and he is in a very good physical shape.

Question: Which friend had a smaller chance of developing atherosclerosis?
Answer: Vic

Situation: Fred was a good athlete in his youth, and so was Vic. Fred started eating junk food and other fatty foods in his 30's. His cholesterol is very high now. Vic became a vegan later,and he is in a very good physical shape.

Question: Which friend had a greater chance of developing atherosclerosis?
Answer: Fred

Situation: Fred was a good athlete in his youth, and so was Vic. Fred started eating junk food and other fatty foods in his 30's. His cholesterol is very high now. Vic became a vegan later,and he is in a very good physical shape.

Question: Which friend had a greater chance of developing high blood pressure?
Answer: Fred

Situation: Fred was a good athlete in his youth, and so was Vic. Fred started eating junk food and other fatty foods in his 30's. His cholesterol is very high now. Vic became a vegan later,and he is in a very good physical shape.

Question: Which friend had a lower chance of developing high blood pressure?
Answer: Vic

Situation: Fred was a good athlete in his youth, and so was Vic. Fred started eating junk food and other fatty foods in his 30's. His cholesterol is very high now. Vic became a vegan later,and he is in a very good physical shape.

Question: Which friend had a decreased blood flow to the heart?
Answer: Fred

Situation: Fred was a good athlete in his youth, and so was Vic. Fred started eating junk food and other fatty foods in his 30's. His cholesterol is very high now. Vic became a vegan later,and he is in a very good physical shape.

Question: Which friend had a normal blood flow to the heart?
Answer: Vic

Situation: Fred was a good athlete in his youth, and so was Vic. Fred started eating junk food and other fatty foods in his 30's. His cholesterol is very high now. Vic became a vegan later,and he is in a very good physical shape.

Question: Which friend received a normal oxygen supply to the heart?
Answer: Vic

Situation: Fred was a good athlete in his youth, and so was Vic. Fred started eating junk food and other fatty foods in his 30's. His cholesterol is very high now. Vic became a vegan later,and he is in a very good physical shape.

Question: Which friend received a decreased oxygen supply to the heart?
Answer: Fred