This study explores the creation of a machine learning model to automatically identify whether a Neonatal Intensive Care Unit (NICU) patient was diagnosed with neonatal jaundice during a particular hospitalization based on their associated clinical notes. We develop a number of techniques for text preprocessing and feature selection and compare the effectiveness of different classification models. We show that using ensemble decision tree classification, both with AdaBoost and with bagging, outperforms support vector machines (SVM), the current state-of-the-art technique for neonatal jaundice coding.
Given the importance and time-intensive nature of medical coding, many scientists have started developing techniques for automated coding @cite_3 . For most of these attempts, the task was narrow (i.e. attempting to predict a single ICD code or a small set of related codes) and utilized a relatively small dataset.
@cite_3
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International Classification of Diseases(ICD) is an authoritative health care classification system of different diseases and conditions for clinical and management purposes. Considering the complicated and dedicated process to assign correct codes to each patient admission based on overall diagnosis, we propose a hierarchical deep learning model with attention mechanism which can automatically assign ICD diagnostic codes given written diagnosis. We utilize character-aware neural language models to generate hidden representations of written diagnosis descriptions and ICD codes, and design an attention mechanism to address the mismatch between the numbers of descriptions and corresponding codes. Our experimental results show the strong potential of automated ICD coding from diagnosis descriptions. Our best model achieves 0.53 and 0.90 of F1 score and area under curve of receiver operating characteristic respectively. The result outperforms those achieved using character-unaware encoding method or without attention mechanism. It indicates that our proposed deep learning model can code automatically in a reasonable way and provide a framework for computer-auxiliary ICD coding. Abstract A multitude of information sources is present in the electronic health record (EHR), each of which can contain clues to automatically assign diagnosis and procedure codes. These sources however show information overlap and quality differences, which complicates the retrieval of these clues. Through feature selection, a denser representation with a consistent quality and less information overlap can be obtained. We introduce and compare coverage-based feature selection methods, based on confidence and information gain. These approaches were evaluated over a range of medical specialties, with seven different medical specialties for ICD-9-CM code prediction (six at the Antwerp University Hospital and one in the MIMIC-III dataset) and two different medical specialties for ICD-10-CM code prediction. Using confidence coverage to integrate all sources in an EHR shows a consistent improvement in F-measure (49.83 for diagnosis codes on average), both compared with the baseline (44.25 for diagnosis codes on average) and with using the best standalone source (44.41 for diagnosis codes on average). Confidence coverage creates a concise patient stay representation independent of a rigid framework such as UMLS, and contains easily interpretable features. Confidence coverage has several advantages to a baseline setup. In our baseline setup, feature selection was limited to a filter removing features with less than five total occurrences in the trainingset. Prediction results improved consistently when using multiple heterogeneous sources to predict clinical codes, while reducing the number of features and the processing time. Multiple-input double-output (MIDO) codes are important in future wireless communications, where the portable end-user device is physically small and uses only two receive antennas. In this paper, we address the design of 4×2 MIDO codes. Starting from a 4×4 space-time block code matrix built from a cyclic division algebra, two ways of puncturing the code are presented, resulting in either a well-shaped MIDO code, or a MIDO code with some orthonormal columns, yielding fast maximum-likelihood (ML) decodability. The well-shaped MIDO code outperforms the fast decodable one through simulations, an indication that the shaping property stays an important code design criterion. We then provide a slightly modified version of the well-shaped MIDO code which both preserves the shaping and increases the orthogonality of its columns in an attempt to speed up the decoding of the code. Finally, we show that a multiple-input single output (MISO) code is actually embedded in the MIDO code, allowing the transmitter to choose between sending a MIDO or MISO code, without having to change the encoder. All the proposed codes have the non-vanishing determinant (NVD) property. Diagnosis prediction aims to predict the future health status of patients according to their historical visit records, which is an important yet challenging task in healthcare informatics. Existing diagnosis prediction approaches mainly employ recurrent neural networks (RNNs) with attention mechanisms to make predictions. However, these approaches ignore the importance of code descriptions, i.e., the medical definitions of diagnosis codes. We believe that taking diagnosis code descriptions into account can help the state-of-the-art models not only to learn meaningful code representations, but also to improve the predictive performance. Thus, in this paper, we propose a simple, but general diagnosis prediction framework, which includes two basic components: diagnosis code embedding and predictive model. To learn the interpretable code embeddings, we apply convolutional neural networks (CNNs) to model medical descriptions of diagnosis codes extracted from online medical websites. The learned medical embedding matrix is used to embed the input visits into vector representations, which are fed into the predictive models. Any existing diagnosis prediction approach (referred to as the base model) can be cast into the proposed framework as the predictive model (called the enhanced model). We conduct experiments on two real medical datasets: the MIMIC-III dataset and the Heart Failure claim dataset. Experimental results show that the enhanced diagnosis prediction approaches significantly improve the prediction performance.