Knowledge base construction is crucial for summarising, understanding and inferring relationships between biomedical entities. However, for many practical applications such as drug discovery, the scarcity of relevant facts (e.g. gene X is therapeutic target for disease Y) severely limits a domain expert's ability to create a usable knowledge base, either directly or by training a relation extraction model. In this paper, we present a simple and effective method of extracting new facts with a pre-specified binary relationship type from the biomedical literature, without requiring any training data or hand-crafted rules. Our system discovers, ranks and presents the most salient patterns to domain experts in an interpretable form. By marking patterns as compatible with the desired relationship type, experts indirectly batch-annotate candidate pairs whose relationship is expressed with such patterns in the literature. Even with a complete absence of seed data, experts are able to discover thousands of high-quality pairs with the desired relationship within minutes. When a small number of relevant pairs do exist - even when their relationship is more general (e.g. gene X is biologically associated with disease Y) than the relationship of interest - our system leverages them in order to i) learn a better ranking of the patterns to be annotated or ii) generate weakly labelled pairs in a fully automated manner. We evaluate our method both intrinsically and via a downstream knowledge base completion task, and show that it is an effective way of constructing knowledge bases when few or no relevant facts are already available.
The idea of extracting entity pairs by discovering textual patterns dates back to early work on bootstrapping for relation extraction with the DIPRE system @cite_1 . This system was designed to find co-occurrences of seed entity pairs of a known relationship type inside unlabelled text, then extract simple patterns (exact string matches) from these occurrences and use them to discover new entity pairs. introduced a pattern evaluation methodology based on the precision of a pattern on the set of entity pairs which had already been discovered; they also used the dot product between word vectors instead of an exact string match to allow for slight variations in text. Later work @cite_3 @cite_2 @cite_5 has proposed more sophisticated pattern extraction methods (based on dependency graphs or kernel methods on word vectors) and different pattern evaluation frameworks (document relevance scores).
@cite_5 @cite_1 @cite_3 @cite_2
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Mining textual patterns in news, tweets, papers, and many other kinds of text corpora has been an active theme in text mining and NLP research. Previous studies adopt a dependency parsing-based pattern discovery approach. However, the parsing results lose rich context around entities in the patterns, and the process is costly for a corpus of large scale. In this study, we propose a novel typed textual pattern structure, called meta pattern, which is extended to a frequent, informative, and precise subsequence pattern in certain context. We propose an efficient framework, called MetaPAD, which discovers meta patterns from massive corpora with three techniques: (1) it develops a context-aware segmentation method to carefully determine the boundaries of patterns with a learnt pattern quality assessment function, which avoids costly dependency parsing and generates high-quality patterns; (2) it identifies and groups synonymous meta patterns from multiple facets---their types, contexts, and extractions; and (3) it examines type distributions of entities in the instances extracted by each group of patterns, and looks for appropriate type levels to make discovered patterns precise. Experiments demonstrate that our proposed framework discovers high-quality typed textual patterns efficiently from different genres of massive corpora and facilitates information extraction. Bootstrapped pattern learning for entity extraction usually starts with seed entities and iteratively learns patterns and entities from unlabeled text. Patterns are scored by their ability to extract more positive entities and less negative entities. A problem is that due to the lack of labeled data, unlabeled entities are either assumed to be negative or are ignored by the existing pattern scoring measures. In this paper, we improve pattern scoring by predicting the labels of unlabeled entities. We use various unsupervised features based on contrasting domain-specific and general text, and exploiting distributional similarity and edit distances to learned entities. Our system outperforms existing pattern scoring algorithms for extracting drug-andtreatment entities from four medical forums. The wealth of interaction information provided in biomedical articles motivated the implementation of text mining approaches to automatically extract biomedical relations. This paper presents an unsupervised method based on pattern clustering and sentence parsing to deal with biomedical relation extraction. Pattern clustering algorithm is based on Polynomial Kernel method, which identifies interaction words from unlabeled data; these interaction words are then used in relation extraction between entity pairs. Dependency parsing and phrase structure parsing are combined for relation extraction. Based on the semi-supervised KNN algorithm, we extend the proposed unsupervised approach to a semi-supervised approach by combining pattern clustering, dependency parsing and phrase structure parsing rules. We evaluated the approaches on two different tasks: (1) Protein–protein interactions extraction, and (2) Gene–suicide association extraction. The evaluation of task (1) on the benchmark dataset (AImed corpus) showed that our proposed unsupervised approach outperformed three supervised methods. The three supervised methods are rule based, SVM based, and Kernel based separately. The proposed semi-supervised approach is superior to the existing semi-supervised methods. The evaluation on gene–suicide association extraction on a smaller dataset from Genetic Association Database and a larger dataset from publicly available PubMed showed that the proposed unsupervised and semi-supervised methods achieved much higher F-scores than co-occurrence based method. Measuring the similarity between semantic relations that hold among entities is an important and necessary step in various Web related tasks such as relation extraction, information retrieval and analogy detection. For example, consider the case in which a person knows a pair of entities (e.g. Google, YouTube), between which a particular relation holds (e.g. acquisition). The person is interested in retrieving other such pairs with similar relations (e.g. Microsoft, Powerset). Existing keyword-based search engines cannot be applied directly in this case because, in keyword-based search, the goal is to retrieve documents that are relevant to the words used in a query -- not necessarily to the relations implied by a pair of words. We propose a relational similarity measure, using a Web search engine, to compute the similarity between semantic relations implied by two pairs of words. Our method has three components: representing the various semantic relations that exist between a pair of words using automatically extracted lexical patterns, clustering the extracted lexical patterns to identify the different patterns that express a particular semantic relation, and measuring the similarity between semantic relations using a metric learning approach. We evaluate the proposed method in two tasks: classifying semantic relations between named entities, and solving word-analogy questions. The proposed method outperforms all baselines in a relation classification task with a statistically significant average precision score of 0.74. Moreover, it reduces the time taken by Latent Relational Analysis to process 374 word-analogy questions from 9 days to less than 6 hours, with an SAT score of 51 .