Impacts of High-Protein Oral Nutritional Supplements Among Malnourished Men and Women with Sarcopenia: A Multicenter, Randomized, Double-Blinded, Controlled Trial. Nutritional status, body composition, and quality of life in community-dwelling sarcopenic and non-sarcopenic older adults: A case-control study. Similar effects of leucine rich and regular dairy products on muscle mass and functions of older polymyalgia rheumatica patients: A randomized crossover trial Dairy intakes affect bone density in the elderly. Nutrient-rich dairy proteins improve appendicular skeletal muscle mass and physical performance, and attenuate the loss of muscle strength in older men and women subjects: a single-blind randomized clinical trial Nutritional factors that influence change in bone density and stress fracture risk among young female cross-country runners. Dietary Intake of Dairy Products, Calcium, and Vitamin D and the Risk of Hypertension in Middle-Aged and Older Women Dairy products, calcium and phosphorus intake, and the risk of prostate cancer: results of the French prospective SU.VI.MAX (Supplémentation en Vitamines et Minéraux Antioxydants) study. Effects of dairy products on bone and body composition in pubertal girls. Consumption of vitamin D-and calcium-fortified soft white cheese lowers the biochemical marker of bone resorption TRAP 5b in postmenopausal women at moderate risk of osteoporosis fracture. Physiological effects beyond the significant gain in muscle mass in sarcopenic elderly men: evidence from a randomized clinical trial using a protein-rich food Epidemiology of sarcopenia among the elderly in New Mexico. Dairy consumption and patterns of mortality of Australian adults Consequences of a plant-based diet with low dairy consumption on intake of bone-relevant nutrients. Dairy products, calcium, and prostate cancer risk in the Physicians' Health Study. Value of sarcopenia assessed by computed tomography for the prediction of postoperative morbidity following oncological colorectal resection: A comparison with the malnutrition screening tool. Relationship Between Calcium, Lactose, Vitamin D, and Dairy Products and Ovarian Cancer Sarcopenia predicts 1-year mortality in elderly patients undergoing curative gastrectomy for gastric cancer: a prospective study The Contribution of Ready-to-Eat Cereals to Daily Nutrient Intake and Breakfast Quality in a Mediterranean Setting Effects of Dietary Calcium Intervention on Adolescent Mothers and Newborns: A Randomized Controlled Trial Lactose maldigestion is not an impediment to the intake of 1500 mg calcium daily as dairy products. Effects of increased consumption of fluid milk on energy and nutrient intake, body weight, and cardiovascular risk factors in healthy older adults. Dietary calcium, phosphorus, vitamin D, dairy products and the risk of colorectal adenoma and cancer among French women of the E3N‐EPIC prospective study
BACKGROUND Recent evidence suggests that nutritional interventions may improve muscle outcomes in malnutrition and sarcopenia . OBJECTIVES We evaluated the effects of 2 high- quality oral nutritional supplements ( ONS ) differing in amount and type of key nutrients in older adult men and women . DESIGN A multicenter , r and omized , double-blinded , controlled clinical trial . PARTICIPANTS Malnourished and sarcopenic men and women , 65 years and older ( n = 330 ) . INTERVENTION A 24-week intervention period with 2 energy-rich ( 330 kcal ) ONS treatment groups : Control ONS ( CONS , 14 g protein ; 147 IU vitamin D3 ) versus Experimental ONS ( EONS , 20 g protein ; 499 IU vitamin D3 ; 1.5 g CaHMB ) taken twice daily . Both ONS also contained other vitamins , minerals , and nutrients in varying amounts . MEASUREMENTS Isokinetic peak torque ( PT , Nm ) leg strength , grip strength ( kg ) , and gait speed ( m·s-1 ) were assessed at baseline and 12 and 24 weeks . Left and right leg muscle mass ( LMM , kg ) were assessed by dual-energy x-ray absorptiometry ( DXA ) . Muscle quality ( MQ ) was leg strength expressed relative to the tested LMM ( Nm·kg-1 ) . Subgroup analyses were performed : severe sarcopenia ( low skeletal mass index , low grip strength [ < 30 kg men ; < 20 kg women ] , low gait speed [ < 0.8 m·s-1 ] ) and mild-moderate sarcopenia ( low skeletal mass index , normal gait speed , or normal grip strength ) . RESULTS Both ONS groups ( EONS and CONS ) improved PT , MQ , grip strength , and gait speed from baseline with no treatment differences . Those with severe sarcopenia ( 44 % ) exhibited lower baseline PT and MQ , with no differences in strength improvements between treatments . However , participants with mild-moderate sarcopenia exhibited higher baseline PT and MQ , with differences in strength improvements at 12 weeks ( EONS > CONS , P = .032 ) in those with normal grip strength . There were no treatment differences based on sarcopenic severity for either grip strength or gait speed . CONCLUSION ONS improved strength outcomes in malnourished older adults with sarcopenia . In those with mild-moderate sarcopenia , but not severe sarcopenia , consumption of the EONS improved leg muscle strength and quality compared with the st and ard CONS BACKGROUND & AIM Sarcopenia , the age-related decrease in muscle mass , strength , and function , is a main cause of reduced mobility , increased falls , fractures and nursing home admissions . Cross-sectional and prospect i ve studies indicate that sarcopenia may be influenced in part by reversible factors like nutritional intake . The aim of this study was to compare functional and nutritional status , body composition , and quality of life of older adults between age and sex-matched older adults with and without sarcopenia . METHODS In a multi-centre setting , non-sarcopenic older adults ( n = 66 , mean ± SD : 71 ± 4 y ) , i.e. Short Physical Performance Battery ( SPPB ) : 11 - 12 and normal skeletal muscle mass index , were recruited to match 1:1 by age and sex to previously recruited adults with sarcopenia : SPPB 4 - 9 and low skeletal muscle mass index . Health-related quality of life , self-reported physical activity levels and dietary intakes were measured using the EQ-5D scale and index , Physical Activity Scale for the Elderly ( PASE ) , and 3-day prospect i ve diet records , respectively . Concentrations of 25-OH-vitamin D , α-tocopherol ( adjusted for cholesterol ) , folate , and vitamin B-12 were assessed in serum sample s. RESULTS In addition to the defined components of sarcopenia , i.e. muscle mass , strength and function , reported physical activity levels and health-related quality of life were lower in the sarcopenic adults ( p < 0.001 ) . For similar energy intakes ( mean ± SD : sarcopenic , 1710 ± 418 ; non-sarcopenic , 1745 ± 513 , p = 0.50 ) , the sarcopenic group consumed less protein/kg ( -6 % ) , vitamin D ( -38 % ) , vitamin B-12 ( -22 % ) , magnesium ( -6 % ) , phosphorus ( -5 % ) , and selenium ( -2 % ) ( all p < 0.05 ) compared to the non-sarcopenic controls . The serum concentration of vitamin B-12 was 15 % lower in the sarcopenic group ( p = 0.015 ) , and all other nutrient concentrations were similar between groups . CONCLUSIONS In non-malnourished older adults with and without sarcopenia , we observed that sarcopenia substantially impacted self-reported quality of life and physical activity levels . Differences in nutrient concentrations and dietary intakes were identified , which might be related to the differences in muscle mass , strength and function between the two groups . This study provides information to help strengthen the characterization of this geriatric syndrome sarcopenia and indicates potential target areas for nutritional interventions Objectives Leucine-rich milk and whey proteins have been suggested for prevention of age related loss of muscle mass and strength i.e. sarcopenia . The effects of milk protein supplementation and low intensity home based physical exercise on body composition and muscle functions were investigated . Design A r and omized double blind crossover trial . Setting Community dwelling members of Helsinki rheumatoid association . Participants Older people ( N = 47 , mean age 69.5 years ) suffering from polymyalgia rheumatica . Intervention Patients performed as many st and ups as possible twice a day after which they ingested a regular ( Control ) or a whey protein enriched dairy product with high leucine content ( Test ) . The 8-week intervention periods were separated by a 4-week wash-out . Measurements Body composition was measured by dual x-ray absorptiometry and muscle functions by h and grip strength , force platform countermovement jump performance , chair st and test , and walking speed . Results The 16-week home-based post-exercise supplementation result ed in a 1.8 % increase ( p = 0.052 ) in lower limb muscle mass . Walking speed ( + 5.3 % , p = 0.007 ) and chair st and test performance ( −12.2 % , p < 0.001 ) were also improved . Furthermore , a tendency for increased jump power ( + 3.0 % , p = 0.084 ) was observed . However , significant and consistent differences were not found in the changes of muscle mass indices or muscle functions between supplements , but the test supplement tended to prevent accumulation of body fat . Conclusion A low intensity home based exercise program combined with post-exercise milk protein supplementation is feasible despite some gastrointestinal complaints and seems effective in improving the muscle mass and functions of older persons with a inflammatory disease . Further studies are needed to establish , whether and to what extent the use of leucine-enriched whey products prevent or treat age-associated sarcopenia and whether they are superior to the present commercial milk products BACKGROUND Race and sex differences in the effect of diet on bone mineral density ( BMD ) at the hip in the elderly are unknown . OBJECTIVES This study related cross-sectional nutrient and dairy product consumption to hip BMD in white and black men and women aged > 60 y and evaluated the influence of nutrient and dairy product consumption on changes in BMD in a white cohort participating in a calcium , vitamin D , or placebo trial . DESIGN The Health Habits and History Question naire was used in 289 white women and 116 white men who participated in the trial and in 265 black women and 75 black men to predict total hip and femoral neck BMD or  changes in BMD . RESULTS Blacks had higher calcium intakes than did whites ( 700 and 654 mg/d , respectively ; P = 0.0094 ) , and men had higher calcium intakes than did women ( 735 and 655 mg/d , respectively ; P = 0.0007 ) . For men , the correlation between total hip BMD and dairy calcium intake after adjustment for age , race , and weight was 0.23 ( P < 0.005 ) ; this relation was not significant in women ( r = 0.02 , P = 0.12 ) . Similar results were found for femoral neck BMD . In the longitudinal study , calcium supplementation reduced bone loss from the total hip and femoral neck in those who consumed < 1.5 servings of dairy products/d and were < 72 y old . CONCLUSIONS Cross-sectional results indicated that higher dairy product consumption is associated with greater hip BMD in men , but not in women . Calcium supplementation protected both men and women from bone loss in the longitudinal study of whites Background At present , it is unknown whether the use of nutrient-rich dairy proteins improves the markers of sarcopenia syndrome . Therefore , our proposal was to investigate whether adding 210 g of ricotta cheese daily would improve skeletal muscle mass , h and grip strength , and physical performance in non-sarcopenic older subjects . Subjects and methods This was a single-blind r and omized clinical trial that included two homogeneous , r and omized groups of men and women over 60 years of age . Participants in the intervention group were asked to consume their habitual diet but add 210 g of ricotta cheese ( IG/HD + RCH ) , while the control group was instructed to consume only their habitual diet ( CG/HD ) . Basal and 12-week follow-up measurements included appendicular skeletal muscle mass ( ASMM ) by dual-energy X-ray absorptiometry , h and grip strength by a h and held dynamometer , and physical performance using the short physical performance battery ( SPPB ) and the stair-climb power test ( SCPT ) . The main outcomes were relative changes in ASMM , strength , SPPB , and SCPT . Results ASMM increased in the IG/HD + RCH ( 0.6±3.5 kg ) , but decreased in the CG/HD ( −1.0±2.6 ) . The relative change between groups was statistically significant ( P=0.009 ) . The relative change in strength in both groups was negative , but the loss of muscle strength was more pronounced in CG/HD , though in this regard statistical analysis found only a tendency ( P=0.07 ) . The relative change in the balance-test scores was positive for the IG/HD + RCH , while in the CG/HD it was negative , as those individuals had poorer balance . In this case , the relative change between groups did reach statistical significance . Conclusion The addition of 210 g of ricotta cheese improves ASMM and balance-test scores , while attenuating the loss of muscle strength . These results suggest that adding ricotta cheese to the habitual diet is a promising dietetic strategy that may improve the markers of sarcopenia in subjects without a pronounced loss of ASMM or sarcopenia OBJECTIVE To identify nutrients , foods , and dietary patterns associated with stress fracture risk and changes in bone density among young female distance runners . DESIGN AND SETTING Two-year , prospect i ve cohort study . Observational data were collected in the course of a multicenter r and omized trial of the effect of oral contraceptives on bone health . PARTICIPANTS One hundred and twenty-five female competitive distance runners ages 18 - 26 years . ASSESSMENT OF RISK FACTORS Dietary variables were assessed with a food frequency question naire . MAIN OUTCOME MEASUREMENTS Bone mineral density and content ( BMD/ BMC ) of the spine , hip , and total body were measured annually by dual x-ray absorptiometry ( DEXA ) .  Stress fractures were recorded on monthly calendars , and had to be confirmed by radiograph , bone scan , or magnetic resonance imaging . RESULTS Seventeen participants had at least one stress fracture during follow-up . Higher intakes of calcium , skim milk , and dairy products were associated with lower rates of stress fracture . Each additional cup of skim milk consumed per day was associated with a 62 % reduction in stress fracture incidence ( P < .05 ) ; and a dietary pattern of high dairy and low fat intake was associated with a 68 % reduction ( P < .05 ) . Higher intakes of skim milk , dairy foods , calcium , animal protein , and potassium were associated with significant ( P < .05 ) gains in whole-body BMD and BMC . Higher intakes of calcium , vitamin D , skim milk , dairy foods , potassium , and a dietary pattern of high dairy and low fat were associated with significant gains in hip BMD . CONCLUSIONS In young female runners , low-fat dairy products and the major nutrients in milk ( calcium , vitamin D , and protein ) were associated with greater bone gains and a lower stress fracture rate . Potassium intake was also associated with greater gains in hip and whole-body BMD Prospect i ve data on the associations between intake of dairy products and its nutrient components with risk of hypertension remain limited . We therefore investigated the associations of intake of dairy products , calcium , and vitamin D with the incidence of hypertension  in a prospect i ve cohort of 28 886 US women aged ≥45 years .  Intake of dairy products , calcium , and vitamin D at baseline were assessed from semiquantitative food frequency question naires . Incident cases of hypertension ( n=8710 ) were identified from annual follow-up question naires during 10 years of follow-up . After adjusting for major hypertension risk factors , the relative risks of incident hypertension across increasing quintiles of low-fat dairy product intake were 1.00 ( reference ) , 0.98 , 0.97 , 0.95 , and 0.89 ( P for trend : 0.001 ) . The risk of hypertension decreased in the higher quintiles of dietary calcium ( multivariate relative risk in the highest quintile : 0.87 ) and dietary vitamin D ( multivariate relative risk in the highest quintile : 0.95 ) , but did not change with calcium or vitamin D supplements . Adjustment for dietary calcium significantly attenuated the inverse association of low-fat dairy intake with risk of hypertension , whereas adjustment for dietary vitamin D did not change the association . The multivariate relative risks across increasing quintiles of high-fat dairy product intake , in contrast , were 1.00 , 1.02 , 1.01 , 1.00 , and 0.97 ( P for trend : 0.17 ) . Our study found that intakes of low-fat dairy products , calcium , and vitamin D were each inversely associated with risk of hypertension in middle-aged and older women , suggesting their potential roles in the primary prevention of hypertension and cardiovascular complications Although dairy products have been found to be associated with an elevated risk of prostate cancer , studies investigating the potential effect of Ca are limited , and findings are inconsistent . The objective of the present study was to test the relationship between the risk of prostate cancer  and consumption of dairy products and Ca . The analysis included 2776 men from the French SU.VI.MAX ( Supplementation en Vitamines et Minéraux Antioxydants ) prospect i ve study , among whom sixty-nine developed prostate cancer during the follow-up period ( median : 7.7 years ) .  Food consumption  was assessed at inclusion from repeated 24 h records and nutrient intake was calculated using a food composition table . A higher risk of prostate cancer was observed among subjects with higher dairy product ( relative risk ( RR ; 95 % CI ) , 4th quartile v. 1st : 1.35 ( 1.02 , 1.78 ) , P = 0.04 ) and Ca intake ( RR ( 95 % CI ) , 4th quartile v. 1st : 2.43 ( 1.05 , 5.62 ) , P = 0.04 ) . Nevertheless , we identified a harmful effect of yoghurt consumption upon the risk of prostate cancer ( RR ( 95 % CI ) , increment 125 g/d : 1.61 ( 1.07 , 2.43 ) , P = 0.02 ) independently of the Ca content . Our data support the hypothesis that dairy products have a harmful effect with respect to the risk of prostate cancer , largely related to Ca content . The higher risk of prostate cancer with linear increasing yoghurt consumption seems to be independent of Ca and may be related to some other component OBJECTIVE To study the effect of calcium supplementation with dairy products on the bone and body composition of pubertal girls . DESIGN R and omized control study with 12-month follow-up . SETTING General community . SUBJECTS Forty-eight white girls whose mean age was 11 years and sexual development at Tanner stage 2 . INTERVENTION One group 's diet was supplemented with dairy products to the recommended dietary allowance of 1200 mg calcium daily . The other group ate their usual diet . MAIN OUTCOME MEASURES Bone mineral content and density were measured at the radius , femoral neck , lumbar spine , and total body bone mineral by single-photon and dual-energy x-ray absorptiometry at the start of the study and after 3 , 6 , 9 , and 12 months . Body composition ( lean body mass and body fat ) was measured by dual-energy x-ray absorptiometry at the same intervals . Serum calcium , phosphate , 25-hydroxyvitamin D , 1,25-dihydroxyvitamin D , alkaline phosphatase , magnesium , and albumin concentrations were determined at the start and end of the study . The urinary calcium/creatinine ratio and hydroxyproline concentration were also determined . RESULTS The dairy group had higher intakes of calcium , phosphate , vitamin D , and protein than control subjects . The dairy group had significantly greater increases during the 1-year study in bone mineral density at the lumbar spine bones ( 22.8 % + /- 6.9 % vs 12.9 % + /- 8.3 % ) and in total body bone mineral ( 14.2 % + /- 7.0 % vs 7.6 % + /- 6.0 % ) than control subjects . Dietary calcium , phosphate , vitamin D , and protein intakes were associated with the lumbar bone density and total body bone calcium . There were no differences in serum or urinary biochemical values between the two groups at the start or end of the study . CONCLUSIONS Young girls whose dietary calcium intake was provided primarily by dairy products at or above the recommended dietary allowances had an increased rate of bone mineralization . Increased intake of dairy foods did not increase overall total or saturated fat intake and was not associated with excessive weight gain or increased body fat The prevention of increased bone remodeling in postmenopausal women at low 10-y risk of osteoporotic fractures essentially relies on reinforcement of environmental factors known to positively influence bone health , among which nutrition plays an important role . In institutionalized women in their mid-eighties , we previously found that consumption of fortified soft plain cheese increased vitamin D , calcium , and protein intakes , reduced bone resorption biochemical markers , particularly the serum bone specific acid phosphatase tartrate resistant acid phosphatase , isoform 5b ( TRAP 5b ) that reflects osteoclast activity , and stimulated the serum bone anabolic factor insulin-like growth factor-I ( IGF-I ) . Whether these effects occur in much younger women was tested in a prospect i ve control study . Seventy-one healthy postmenopausal women aged 56.6 ± 3.9 y ( mean ± SD ) with low spontaneous supply of both Ca and vitamin D were r and omized to consume daily ( treated , n = 36 ) or not ( controls , n = 35 ) two servings ( 2 × 100 g ) of skimmed-milk , soft plain cheese for 6 wk . The vitamin D and Ca-fortified dairy product provided daily : 661 kJ , 2.5 μg vitamin D , 400 mg calcium , and 13.8 g protein . At the end of the intervention , the decrease in TRAP 5b and the increase in IGF-I were greater in the treated than in the control group ( P < 0.02 ) . The changes in serum carboxy terminal crosslinked telopeptide of type I collagen did not differ significantly between the two groups . In conclusion , like in elderly women , consumption by healthy postmenopausal women of a vitamin D and calcium-fortified dairy product that also increases the protein intake , reduces the serum concentration of the bone resorption biomarker TRAP 5b . This response , combined with the increase in serum IGF-I , is compatible with a nutrition-induced reduction in postmenopausal bone loss rate Background Sarcopenia is strongly associated with an inadequate intake of dietary protein . Dietary protein supplementation boosts muscle-protein synthesis and increases muscle mass in the elderly . This study tested whether adding a protein-rich food , ricotta cheese , to the habitual diet increased total appendicular skeletal muscle mass and strength in elderly people . Methods Participants ( n = 40 ) , were sarcopenic elderly men and women over 60 years of age . Two comparison groups were formed at r and om and followed for 3 months : the intervention group received 210 g/day of ricotta cheese plus the habitual diet , while the control group followed the habitual diet with no additional intervention . Total appendicular skeletal muscle ( TASM ) was assessed by dual-energy X-ray absorptiometry , while strength was measured using a h and held dynamometer at baseline and after the intervention period . The primary outcomes were the percentage of relative change in TASM and strength . Results The percentage of relative change in TASM was not significant between the groups after the intervention period . Muscle strength improved in the intervention group , but showed only a tendency towards significance ( P = 0.06 ) . Secondary analysis showed that the men in the intervention group gained 270 g in TASM compared to those in the control group , and improved their fasting insulin levels ( P = 0.05 ) , muscle strength , lean body mass in the arms , and body weight variables . Conclusion The results of this study indicate that a nutritional intervention using a high- quality protein food , specifically ricotta cheese , in order to increase the amount of protein intake might not be regarded as fully promising in elderly men and women with sarcopenia . However , the gender effects on muscle strength , lean tissue in the arms , homeostatic assessment of insulin resistance , and body weight detected in this study suggest that additional research is needed on elderly male subjects with sarcopenia Muscle mass decreases with age , leading to " sarcopenia , " or low relative muscle mass , in elderly people . Sarcopenia is believed to be associated with metabolic , physiologic , and functional impairments and disability . Methods of estimating the prevalence of sarcopenia and its associated risks in elderly population s are lacking . Data from a  population -based survey of 883 elderly Hispanic and non-Hispanic white men and women living in New Mexico ( the New Mexico Elder Health Survey , 1993 - 1995 ) were analyzed to develop a method for estimating the prevalence of sarcopenia . An anthropometric equation for predicting appendicular skeletal muscle mass was developed from a r and om sub sample ( n = 199 ) of participants and was extended to the total sample . Sarcopenia was defined as appendicular skeletal muscle mass (kg)/height2 ( m2 ) being less than two st and ard deviations below the mean of a young reference group . Prevalences increased from 13 - 24 % in persons under 70 years of age to > 50 % in persons over 80 years of age , and were slightly greater in Hispanics than in non-Hispanic whites . Sarcopenia was significantly associated with self-reported physical disability in both men and women , independent of ethnicity , age , morbidity , obesity , income , and health behaviors . This study provides some of the first estimates of the extent of the public health problem posed by sarcopenia Background / Objectives : Dairy foods contain various nutrients that may affect health . We investigated whether intake of dairy products or related nutrients is associated with  mortality due to cardiovascular disease ( CVD ) , cancer and all causes . Subjects/ Methods : We carried out a 16-year prospect i ve study among a community-based sample of 1529 adult Australians aged 25–78 years at baseline . Habitual intakes of dairy products ( total , high/low-fat dairy , milk , yoghurt and full-fat cheese ) , calcium and vitamin D were estimated as mean reported intake using vali date d food frequency question naires ( FFQs ) self-administered in 1992 , 1994 and 1996 . National Death Index data were used to ascertain mortality and cause of death between 1992 and 2007 . Hazard ratios ( HRs ) were calculated using Cox regression analysis . Results : During an average follow-up time of 14.4 years , 177 participants died , including 61 deaths due to CVD and 58 deaths due to cancer . There was no consistent and significant association between total dairy intake and total or cause-specific mortality . However , compared with those with the lowest intake of full-fat dairy , participants with the highest intake ( median intake 339 g/day ) had reduced death due to CVD ( HR : 0.31 ; 95 % confidence interval ( CI ) : 0.12–0.79 ; P for trend=0.04 ) after adjustment for calcium intake and other confounders . Intakes of low-fat dairy , specific dairy foods , calcium and vitamin D showed no consistent associations . Conclusions : Overall intake of dairy products was not associated with mortality . A possible beneficial association between intake of full-fat dairy and cardiovascular mortality needs further assessment and confirmation OBJECTIVE This study examines the extent to which a plant-based dietary intervention that discourages consumption of dairy products and meat influences bone-relevant nutrients . METHODS A r and omized controlled study design was used to evaluate the Coronary Health Improvement Project . The Project is a heart disease prevention intervention administered in an intensive 40-hour educational course delivered over a 4-week period . Participants were evaluated at baseline , 6 weeks , and 6 months . RESULTS After 6 weeks , participants in the intervention group compared with the control group experienced significant increases in magnesium and daily intake of fruit , vegetables , and grains but significant decreases in dairy servings per day and calcium and vitamin D from food . After 6 months , those in the intervention group showed significant increases in daily intake of fruit , vegetables , and grains and significant decreases in dairy servings per day , daily meat consumption , and protein , phosphorous , calcium , total calcium , and vitamin D from food . Serum calcium levels are the primary determinant of parathyroid hormone ( PTH ) release , and within 6 weeks , the intervention group 's PTH levels were elevated from baseline and significantly different from the control group 's PTH levels . At 6 months , urinary type I collagen N-telopeptide ( NTx ) levels were significantly greater in the intervention group compared with the control group . CONCLUSIONS The Coronary Health Improvement Project increases the intake of important food items but decreases calcium and vitamin D consumption . There is also some evidence of an increase in NTx biomarkers , consistent with increased bone resorption BACKGROUND A high calcium intake , mainly from dairy products , may increase prostate cancer risk by lowering concentrations of 1,25-dihydroxyvitamin D(3 ) [ 1,25(OH)(2)D(3 ) ] , a hormone thought to protect against prostate cancer . The results of epidemiologic studies of this hypothesis are inconclusive . OBJECTIVE We investigated the association between dairy product and calcium intakes and prostate cancer risk in the Physicians ' Health Study , a cohort of male US physicians . DESIGN At baseline , the men answered abbreviated dietary question naires . During 11 y of follow-up , we documented 1012 incident cases of prostate cancer among 20885 men . We estimated dairy calcium intake on the basis of consumption of 5 major dairy products and used logistic regression to estimate relative risk . RESULTS At baseline , men who consumed > 600 mg Ca/d from skim milk had lower plasma 1,25(OH)(2)D(3 ) concentrations than did those consuming < or = 150 mg Ca/d [ 71 compared with 85 pmol/L ( 30.06 compared with 35.64 pg/mL ) ; P = 0.005 ] . Compared with men consuming < or = 0.5 daily servings of dairy products , those consuming > 2.5 servings had a multivariate relative risk of prostate cancer of 1.34 ( 95 % CI : 1.04 , 1.71 ) after adjustment for baseline age , body mass index , smoking , exercise , and r and omized treatment assignment in the original placebo-controlled trial . Compared with men consuming < or = 150 mg Ca/d from dairy products , men consuming > 600 mg/d had a 32 % higher risk of prostate cancer ( 95 % CI : 1.08 , 1.63 ) . CONCLUSIONS These results support the hypothesis that dairy products and calcium are associated with a greater risk of prostate cancer BACKGROUND Computed tomography ( CT ) can be used for accurate estimation of whole-body muscle mass and muscle density and for detection of sarcopenia . The goal of this study was to evaluate the additional value of CT measured sarcopenia and muscle attenuation alongside the Malnutrition Universal Screening Tool ( MUST ) for the prediction of post-operative morbidity after oncological colorectal resection , whilst correcting for known risk factors . METHODS A prospect i ve cohort study of 80 patients undergoing elective colorectal surgery in the Netherl and s. Patients were screened for nutritional risk upon admission using the MUST . Additionally , preoperative CT scans were used to determine skeletal muscle mass for the detection of sarcopenia and muscle attenuation . Univariate and multivariable analyses were performed to evaluate associations between the MUST , muscle attenuation and sarcopenia on the one h and and post-operative complications measured by the Clavien-Dindo score on the other h and . RESULTS American Society of Anesthesiology-classification ( ASA ) ≥3 , age ≥70 , MUST ≥2 and lower than median muscle attenuation were significantly associated with a higher risk for postoperative complications ( Clavien-Dindo score ≥2 ) ( p ≤ 0.05 ) , whereas sarcopenia was not ( p = 0.59 ) . Multivariate analyses showed that only MUST ≥2 remained significantly associated with postoperative complications when corrected for age ( p = 0.03 , OR 5.8 , 95%CI 1.1 - 29.6 ) , but not when corrected for age ≥70 and ASA ≥3 . Muscle attenuation and sarcopenia were not significantly associated with postoperative complications . CONCLUSION Our results suggest that using CT measured sarcopenia may have only little additional value over the MUST for the prediction of increased short-term post-operative morbidity after oncological colorectal surgery . It also underlines the importance of currently implemented easy-to-use nutritional screening tools ( MUST ) and raises the question of the evaluation of muscle quality versus quantity in body composition imaging . However , further research is needed to investigate the role of sarcopenia for predicting outcome after colorectal surgery , and investigate the role of muscle attenuation measurements for the prediction of muscle function . CATEGORY OF SU BMI SSION : observational study Abstract : Few prospect i ve studies of the relationship between intake of dairy foods , calcium , vitamin D , and lactose and ovarian cancer have been conducted , and results have been largely inconsistent . Two recent studies found significant increased risk with frequent dairy consumption and perhaps with high intakes of calcium or lactose . The authors investigated the association between these foods and nutrients and ovarian cancer risk among 31,925 subjects in the Breast Cancer Detection Demonstration Project follow-up cohort .  Multivariable ( MV ) relative risks ( RRs ) adjusted for age , parity , and other factors were estimated using Cox proportional hazards models . Over an average follow-up of 8.3 yr , 146 incident ovarian cancer cases were confirmed . Higher intakes of total dairy food ( comparing four or more servings per day vs. less than one serving per day ) were associated with a statistically significant decreased risk of ovarian cancer , although the trend was not significant ( MV RR = 0.42 ; 95 % confidence interval ( CI ) = 0.20–0.89 ; P for trend = 0.07 ) . Comparing extreme quartiles , we observed a statistically nonsignificant inverse association between high dietary calcium intake and ovarian cancer ( RR = 0.67 ; 95 % CI = 0.43 , 1.04 ; P for trend = 0.08 ) . No statistically significant relations were found for consumption of specific dairy foods , lactose , or vitamin D and ovarian cancer risk . The possibility of a decreased risk of ovarian cancer for dietary calcium merits further evaluation Purpose One-year mortality is vital for elderly oncologic patients undergoing surgery . Recent studies have demonstrated that sarcopenia can predict outcomes after major abdominal surgeries , but the association of sarcopenia and 1-year mortality has never been investigated in a prospect i ve study . Methods We conducted a prospect i ve study of elderly patients ( ≥65 years ) who underwent curative gastrectomy for gastric cancer from July 2014 to July 2015 . Sarcopenia was determined by the measurements of muscle mass , h and grip strength , and gait speed . Univariate and multivariate analyses were used to identify the risk factors associated with 1-year mortality . Results A total of 173 patients were included , in which 52 ( 30.1 % ) patients were identified as having sarcopenia . Twenty-four ( 13.9 % ) patients died within 1 year of surgery . Multivariate analysis showed that sarcopenia was an independent risk factor for 1-year mortality . Area under the receiver operating characteristic curve demonstrated an increased predictive power for 1-year mortality with the inclusion of sarcopenia , from 0.835 to 0.868 . Solely low muscle mass was not predictive of 1-year mortality in the multivariate analysis . Conclusions Sarcopenia is predictive of 1-year mortality in elderly patients undergoing gastric cancer surgery . The measurement of muscle function is important for sarcopenia as a preoperative assessment tool Objectives : To examine if and how ready-to-eat cereals ( RTEC ) contribute to the quality of the diet of children , adolescents and young adults in a Mediterranean setting . Methods : A r and om sample of 3534 subjects aged 2 to 24 years in Spain was studied . Food and nutrient intakes were determined by a 24 hour recall . RTEC consumption was assessed by a quantitative food frequency question naire . Additional questions on socioeconomic level and nutritional knowledge were administered . Cereal consumption was classified into non-consumers and daily intakes between 1 and 20 g , 21 and 40 g , and more than 40 g . After excluding the underreporters the final sample consisted of 2852 individuals . Results : About half of the population ( 49.8 % ) reported eating RTEC .  Macronutrient profile improved with increasing cereal consumption . Intakes of thiamine , riboflavin and vitamin B6 increased significantly with increasing consumption of RTEC in all age-sex groups , whereas niacin and folate intake improved in almost all groups and calcium , iron and vitamin D in at least half of the groups . Except for magnesium , vitamin B12 and vitamin E in males , consumption of RTEC was significantly associated with increased coverage of the daily nutrient requirements for all micronutrients studied . Higher levels of  RTEC  consumption was associated with a greater consumption of dairy products , and related to better breakfast quality . Conclusions : Level of RTEC consumption is associated with a better nutritional profile in the diets of Spanish children , adolescents and young adults and a lower risk for inadequate micronutrient intakes . RTEC consumers have better quality breakfasts , in terms of both food choices as well as energy and nutrient content OBJECTIVE : To evaluate the effects of dietary calcium ( Ca ) intervention on adolescent pregnant mothers and their newborns . METHODS : Seventy-two pregnant adolescent mothers were r and omized into one of 3 groups : control , orange juice fortified with calcium , and dairy . The orange juice and dairy groups were required to take more than 1,200 mg Ca . Calcium tablets were added for those not able to meet required Ca . Maternal and infant weight , length , and blood pressure ( BP ) were recorded . Maternal dietary records were evaluated . Mother ’s blood was drawn for serum Ca , phosphate ( P ) , magnesium ( Mg ) , and vitamin 25-hydroxyvitamin D ( D ) . Cord blood was collected for serum Ca and D. Newborn total body Ca was determined . RESULTS : All mothers were similar in weight , height , and BP . Mothers in the orange juice plus calcium and dairy groups had higher intakes of Ca ( 1,472 mg and 1,771 mg ) than controls ( 862 mg ) . One half of the mothers in the orange juice plus calcium group required Ca tablets . Mothers in the dairy group had higher intakes of P , D , and Mg , higher serum folate and D , and higher cord D levels . Mothers in the orange juice plus calcium group had higher serum P but lower serum folate and D. Infants ( 3,517±273 g ) in the dairy group were heavier than infants in the control ( 3,277±177 g ) and orange juice plus calcium ( 3,292±165 g ) groups . Infants in the dairy group had higher total body calcium than control infants . CONCLUSION : Calcium diet supplemented with dairy products during adolescent pregnancy result ed in higher maternal vitamin D and folate serum levels and higher newborn weight and bone mineralization compared with controls . CLINICAL TRIAL REGISTRATION : Clinical Trials.gov , www . clinical trials.gov , NCT00320125 LEVEL OF EVIDENCE : BACKGROUND A National Institutes of Health consensus conference concluded that a daily calcium intake of 1500 mg reduces the severity of osteoporosis . Because dairy products are the main natural source of dietary calcium , a diet providing 1500 mg Ca must contain large quantities of dairy products . However , it is widely believed that the lactose content of these products will not be tolerated by persons with lactose maldigestion ( approximately 30 % of the adult US population ) . OBJECTIVE We evaluated the symptoms of lactose maldigestion and digestion when the diet was supplemented with dairy products providing 1300 mg Ca/d . DESIGN Sixty-two women ( 31 with lactose maldigestion and 31 without ) were studied in a double-blind , r and omized protocol . Symptoms were compared during 1-wk periods when the diet was supplemented with 480 mL ( 2 cups ) milk , 56 g cheese , and 240 mL yogurt provided as conventional products ( 34 g lactose/d ) or as lactose-hydrolyzed products ( 2 g lactose/d ) . RESULTS Women who digested lactose reported no significant difference in symptoms between the 2 treatment periods . Women with lactose maldigestion reported significantly increased flatus frequency and subjective impression of rectal gas during the period of high lactose intake ; however , bloating , abdominal pain , diarrhea , and the global perception of overall symptom severity were not significantly different between the 2 treatment periods . CONCLUSION The symptoms result ing from lactose maldigestion are not a major impediment to the ingestion of a dairy-rich diet supplying approximately 1500 mg Ca/d OBJECTIVE To assess the impact of increased consumption of milk , without other dietary advice , on older adults '  energy and nutrient intakes , weight , cardiovascular risk factors ( blood pressure , plasma lipid levels ) , and quality of life . SUBJECTS/ SETTING Two hundred four healthy men and women , aged 55 to 85 years , who consumed fewer than 1.5 dairy servings per day were chosen from six US academic health centers . DESIGN R and omized , controlled open trial . INTERVENTION Advice to increase skim or 1 % milk intake by 3 cups per day ( n = 101 ) or to maintain usual diet ( n = 103 ) for 12 weeks after a 4-week baseline period . MAIN OUTCOME MEASURES Changes in energy and nutrient intake assessed from 3-day food records , body weight , blood pressure , and plasma lipid levels . STATISTICAL ANALYSES PERFORMED Group-by-time analysis of variance with repeated- measures , chi 2 test . RESULTS Compliance with the intervention was good . Compared with controls , participants in the milk-supplemented group significantly increased energy , protein , cholesterol , vitamins A , D , and B-12 , riboflavin , pantothenate , calcium , phosphorus , magnesium , zinc , and potassium intakes . Prevalence of nutrient inadequacy , assessed for nutrients with Estimated Average Requirements , decreased among women in the milk group for magnesium ( 40 % at baseline vs 13 % at 12 weeks , P < .001 ) and vitamin B-12 ( 6 % vs 0 % , P < .05 ) and tended to decrease ( P < .10 ) for protein and thiamin ( women ) and magnesium and vitamin B-6 ( men ) . The milk group gained 0.6 kg more than control group ( P < .01 ) ; however , weight gain was less than predicted , which suggests some compensation for the added energy from milk . Blood pressure decreased similarly over time in both groups . Total and low-density lipoprotein cholesterol levels , and the ratio of total cholesterol to high-density lipoprotein cholesterol , were unchanged . Triglyceride levels increased within the normal range in the milk group ( P = .002 ) . Quality of life scores were high at baseline and remained high throughout . APPLICATIONS/ CONCLUSIONS Older adults can successfully increase milk intake , thereby meaningfully improving their nutrient intakes . Dietitians can play a key role in disseminating this advice A protective effect of calcium and /or dairy products on  colorectal cancer  has been reported in epidemiological studies but the findings are considered inconsistent . In particular , it is unclear whether they act at a particular step of the adenoma‐carcinoma sequence . To investigate the effect of dairy product consumption and dietary calcium , vitamin D and phosphorus intake on the adenoma‐carcinoma sequence in the French E3N‐EPIC prospect i ve study . The population for the study of risk factors for adenomas was composed of 516 adenoma cases , including 175 high‐risk adenomas , and of 4,804 polyp‐free subjects confirmed by colonoscopy . The population for the colorectal cancer study was composed of 172 cases and 67,312 cancer‐free subjects .  Diet was assessed using a self‐administered question naire completed at baseline . There was a trend of decreasing risk of both adenoma ( ptrend= 0.04 ) and cancer ( ptrend=0.08 ) with increasing calcium intake , with RRs for adenoma and cancer of 0.80 ( IC 95%=0.62–1.03 ) and 0.72 ( 95 % CI=0.47–1.10 ) , respectively , in the fourth quartile compared to the first . A protective effect of dairy products on adenoma ( RRQ4 vs. Q1= 0.80 , 95 % CI=0.62‐1.05 , ptrend= 0.04 ) was observed and of milk consumption on colorectal cancer ( RRQ4vs . Q1= 0.54 , 95 % CI=0.33–0.89 , ptrend= 0.09 ) , although the latter did not reach significance . Phosphorus  intake also decreased the risk of adenoma ( RRQ4 vs. Q1=0.70 , 95 % CI=0.54–0.90 , ptrend= 0.005 ) .  No vitamin D effect was identified . Our data support the hypothesis that calcium , dairy products and phosphorus exert a protective effect at certain steps of the adenoma‐carcinoma sequence . © 2005 Wiley‐Liss ,
This systematic review highlights the effects of dairy products on muscle mass , muscle strength and body performance in the elderly population in the perspective of Ca , P , vitamin D and protein
The risk of sarcopenia increases with aging .
Malnutrition in the elderly population is an important risk factor for sarcopenia .
Calcium ( Ca ) , phosphate ( P ) , vitamin D and protein are key nutrients for the human body and affect muscle mass and quality .
Dairy products are rich in these nutrients , which implicates that dairy products might be ideal for elderly population .