Thyroid Cancer and NVP-BEZ235 Figure 6. Combination therapy of BEZ235 with paclitaxel has synergistic effects against ATC. A, Dm was calculated using cytotoxicity data using CompuSyn software for each drug on each cell line at day 4. B, the cytotoxic effects of BEZ235 and chemotherapeutic agents (paclitaxel, irinotecan and etoposide) alone or in combination after a 4-day treatment in ATC were evaluated using LDH assays. The combination of BEZ235 and PLOS ONE | www.plosone.org 8 October 2012 | Volume 7 | Issue 10 | e46726