HSPG Regulates Trans-Synaptic Signaling Figure 1. Glycan-related gene RNAi screen for synapse structure/function defects. Transgenic RNAi screen interrogating effects of glycan- related gene knockdown on the morphology and function of the Drosophila neuromuscular junction (NMJ) synapse. All VDRC UAS-RNAi lines were PLOS Genetics | www.plosgenetics.org 3 November 2012 | Volume 8 | Issue 11 | e1003031