Intrinsic Role of CFTR in Skeletal Muscle Figure 2. Confocal localization of CFTR in skeletal muscle. (A) Double labeling for CFTR and either membrane- (dystrophin) or SR- (IP3R) associated proteins in transverse and longitudinal sections of human skeletal muscle. (B) Double labeling of CFTR and SR (IP3R or RyR) proteins in longitudinal sections of Cftr+/+ and Cftr2/2 mouse skeletal muscle (scale bar = 10 mm). (C) Triple labeling of IP3R, CFTR, and myonuclei (DAPI) in cultured mouse myotubes. doi:10.1371/journal.pgen.1000586.g002 PLoS Genetics | www.plosgenetics.org 4 July 2009 | Volume 5 | Issue 7 | e1000586