A Jak3 Mutation Protects against Cerebral Malaria Figure 3. Phenotypic expression of resistance to cerebral malaria in mice from pedigree 48. G3 and F2 mice homozygote (P48/P48) or heterozygote (P48/+) for the B6-derived mutant central chromosome 8 were identified by genotyping, and were subjected to several analyses, along with parental C57BL/6J, C57BL/10J and 129S1/SvlmJ controls. (A) Macroscopic examination of thymus from control and mutants showing severely PLoS ONE | www.plosone.org 6 February 2012 | Volume 7 | Issue 2 | e31012