Intrinsic Role of CFTR in Skeletal Muscle Figure 7. Effects of CFTR status on diaphragmatic contractile function. (A) Response of intact diaphragmatic muscle fibers to KCl-induced depolarization in Cftr+/+ versus Cftr2/2 groups, under basal conditions (N = 6–7 mice per group) or with CFTR- inh172 (N = 4–5 mice per group) added to the perfusate (100 mM). (B,C): Effects of CFTR deficiency on relaxation and contraction times of the diaphragm during electrical stimulation (white bars: Cftr+/+; red bars: Cftr2/2). (D) Differential effects of Pseudomonas lung infection on diaphragmatic force capacity in Cftr+/+ and Cftr2/2 mice (N = 5 mice per group). * p,0.05 for Cftr+/+ versus Cftr2/2. doi:10.1371/journal.pgen.1000586.g007 PLoS Genetics | www.plosgenetics.org 10 July 2009 | Volume 5 | Issue 7 | e1000586