M. tuberculosis and SR-B1 Figure 5. The role of SR-B1 in vivo following high dose infection with Mtb. Wild type C57/BL6 and SR-B12/2 mice were infected with 1000 CFU Mycobacterium tuberculosis H37Rv by aerosol route and sacrificed after 4 months. (A) Body weight was monitored throughout the course of the experiment and is presented as % of original body weight (time of infection) with the SEM shown as solid lines for wild type animals and dashed lines for SR-B12/2 mice. Lungs of infected animals were analysed for bacterial burden (B), TNF, IFNc, IL10, IL12p70 and IL6 (C), histopathology (D) and inflammatory lesion size (E), with the black circles representing wild type and the open circles representing SR-B12/2 animals. Shown are the data from individual mice and the median value. *, p,0.05. doi:10.1371/journal.pone.0008448.g005 PLoS ONE | www.plosone.org 8 December 2009 | Volume 4 | Issue 12 | e8448