43. Lee YS, Lim KH, Guo X, Kawaguchi Y, Gao Y, et al. (2008) The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis. Cancer Res 68: 7561–7569. 44. Porter AG, Janicke RU (1999) Emerging roles of caspase-3 in apoptosis. Cell Death Differ 6: 99–104. 45. Ribeil JA, Zermati Y, Vandekerckhove J, Cathelin S, Kersual J, et al. (2007) Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1. Nature 445: 102–105. 46. Janicke RU, Sprengart ML, Wati MR, Porter AG (1998) Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem 273: 9357–9360. STAT2, Caspase3 and HDAC6 as Hsp27 Client Proteins 47. Hideshima T, Bradner JE, Wong J, Chauhan D, Richardson P, et al. (2005) Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma. Proc Natl Acad Sci U S A 102: 8567–8572. 48. Stengel F, Baldwin AJ, Painter AJ, Jaya N, Basha E, et al. (2010) Quaternary dynamics and plasticity underlie small heat shock protein chaperone function. Proc Natl Acad Sci U S A 107: 2007–2012. 49. Plescia J, Salz W, Xia F, Pennati M, Zaffaroni N, et al. (2005) Rational design of shepherdin, a novel anticancer agent. Cancer Cell 7: 457–468. PLoS ONE | www.plosone.org 11 January 2012 | Volume 7 | Issue 1 | e29719