Wnts Specify LRP6 mAb Activity Figure 2. LRP6 antibodies can have different effects on autocrine Wnt signaling in other cell lines. (A) Summary table of 11 cell lines displaying autocrine Wnt signaling inhibited by Fzd8CRD-Fc protein (10 mg/ml), and the effects of LRP6 antibodies on autocrine signaling. The fold change in autocrine Wnt signaling is highlighted in red or green to indicate inhibition or potentiation, respectively, with p-value ,0.01 by one-way analysis of variance (ANOVA). Antibodies were used at 10 mg/ml, except for NCI-H358 and HT-1080 cells which were treated with 1 mg/ml PLoS ONE | www.plosone.org 5 September 2010 | Volume 5 | Issue 9 | e12682