Novel Inhibitor of Geranylgeranyltransferase-I p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells. J Biol Chem 272: 13–16. 43. Hu W, Bellone CJ, Baldassare JJ (1999) RhoA stimulates p27(Kip) degradation through its regulation of cyclin E/CDK2 activity. J Biol Chem 274: 3396–3401. 44. Croft DR, Olson MF (2006) The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms. Mol Cell Biol 26: 4612–4627. 45. Joyce PL, Cox AD (2003) Rac1 and Rac3 are targets for geranylgeranyl- transferase-I inhibitor-mediated inhibition of signaling, transformation, and membrane ruffling. Cancer Res 63: 7959–7967. PLoS ONE | www.plosone.org 13 October 2011 | Volume 6 | Issue 10 | e26135