Intrinsic Role of CFTR in Skeletal Muscle Figure 6. Hyperinflammatory phenotype of Cftr2/2 skeletal muscle in vivo. (A) Cytokine mRNA expression levels in Cftr+/+ versus Cftr2/2 diaphragms for uninfected (CTL) and Pseudomonas-infected (day 2) mice. N = 4–5 mice per group; * p,0.05 for control versus infected mice, { p,0.05 for Cftr+/+ versus Cftr2/2. (B) Real-time PCR quantification of the E3 ubiquitin ligases MuRF-1 and atrogin-1 in diaphragms of control and infected mice. * p,0.05 for Cftr+/+ versus Cftr2/2. doi:10.1371/journal.pgen.1000586.g006 PLoS Genetics | www.plosgenetics.org 8 July 2009 | Volume 5 | Issue 7 | e1000586