Multi-Potent Sca-1+ CPCs of human diseases and their application for genomic studies. Physiol Genomics 16: 349–360. 14. Jiang S, Haider H, Idris NM, Salim A, Ashraf M (2006) Supportive interaction between cell survival signaling and angiocompetent factors enhances donor cell survival and promotes angiomyogenesis for cardiac repair. Circ Res 99: 776–784. 15. Kim HW, Lin A, Guldberg RE, Ushio-Fukai M, Fukai T (2007) Essential role of extracellular SOD in reparative neovascularization induced by hindlimb ischemia. Circ Res 101: 409–419. 16. McKinney-Freeman SL, Naveiras O, Yates F, Loewer S, Philitas M, et al. (2009) Surface antigen phenotypes of hematopoietic stem cells from embryos and murine embryonic stem cells. Blood 114: 268–278. 17. Lai L, Alaverdi N, Maltais L, Morse HC (1998) Mouse cell surface antigens: nomenclature and immunophenotyping. J Immunol 160: 3861–3868. 18. Tateishi K, Ashihara E, Takehara N, Nomura T, Honsho S, et al. (2007) Clonally amplified cardiac stem cells are regulated by Sca-1 signaling for efficient cardiovascular regeneration. J Cell Sci 120: 1791–1800. 19. Leri A, Barlucchi L, Limana F, Deptala A, Darzynkiewicz Z, et al. (2001) Telomerase expression and activity are coupled with myocyte proliferation and preservation of telomeric length in the failing heart. Proc Natl Acad Sci U S A 98: 8626–8631. 20. Park IK, Qian D, Kiel M, Becker MW, Pihalja M, et al. (2003) Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423: 302–305. 21. Holmes C, Stanford WL (2007) Concise review: stem cell antigen-1: expression, function, and enigma. Stem Cells 25: 1339–1347. 22. Cai CL, Liang X, Shi Y, Chu PH, Pfaff SL, et al. (2003) Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev Cell 5: 877–889. 23. Tomita Y, Matsumura K, Wakamatsu Y, Matsuzaki Y, Shibuya I, et al. (2005) Cardiac neural crest cells contribute to the dormant multipotent stem cell in the mammalian heart. J Cell Biol 170: 1135–1146. 24. Thiery JP, Sleeman JP (2006) Complex networks orchestrate epithelial- mesenchymal transitions. Nat Rev Mol Cell Biol 7: 131–142. 25. Yi BA, Wernet O, Chien KR (2010) Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration. J Clin Invest 120: 20–28. 26. Wu SM, Fujiwara Y, Cibulsky SM, Clapham DE, Lien CL (2006) Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell 127: 1137–1150. 27. Urbanek K, D. Torella D, Sheikh E, De Angelis A, Nurzynska D, et al. (2005) Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure. Proc Natl Acad Sci USA 102: 8692–8697. 28. Wilson R, Chen X, Kubo H, et al. (2007) Phenotype and function of c-kit+- derived amplifying myocytes. In: Leri A, Anversa P, Frishman WH, eds. Cardiovascular Regeneration and Stem Cell Therapy Blackwell/Futura, Oxford, UK. pp 77–85. 29. Kubalak SW, Miller-Hance WC, O’Brien TX, Dyson E, Chien KR (1994) Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis. J Biol Chem 269: 16961–16970. 30. Kattman SJ, Huber TL, Keller GM (2006) Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages. Dev Cell 11: 723–732. 31. Srivastava D, Olson EN (2000) A genetic blueprint for cardiac development. Nature 407: 221–226. 32. Domian IJ, Chiravuri M, van der Meer P, Feinberg AW, Shi X, et al. (2009) Generation of functional ventricular heart muscle from mouse ventricular progenitor cells. Science 326: 426–429. PLoS ONE | www.plosone.org 11 September 2011 | Volume 6 | Issue 9 | e25265