Protein ID MAL13P1.307 MAL13P1.92 PF07_0073 PF11_0348 PF13_0198 PFC0135c PFC0365w PFC0730w PFF0335c PFF0615c PFI0235w PFI0290c PFI1175c PFL0580w PFL1420w PFL1620w MAL13P1.343 MAL8P1.127 PF07_0040 PF08_0121 PF10_0043 PF10_0111 PF11_0053 PF11_0384 PF13_0199 PF14_0242 PFB0835c PFC0720w PFC0915w PFE0915c PFE1250w PFF0445w PFF0885w PFL2390c PFL2465c MAL7P1.38 PF11_0061 PF11_0142 PF11_0424 PF13_0102 PF13_0224 PF13_0252 PF14_0215 PF14_0231 PF14_0567 PFC0262c PFC0535w PFC0900w PFC0945w PFD0385w Description hypothetical protein 40S ribosomal protein S15 seryl-tRNA synthetase hypothetical protein reticulocyte binding protein 2 homolog a conserved protein conserved protein conserved protein hypothetical protein P. falciparum membrane protein pf12 precursor replication factor A-related protein beta subunit of coatomer complex RNA-binding protein DNA replication licensing factor mcm5 macrophage migration inhibitory factor homolog asparagine/aspartate rich protein proteasome regulatory subunit hypothetical protein lysophospholipase-like protein peptidyl-prolyl cis-trans isomerase precursor ribosomal protein L13 20S proteasome beta subunit PfSNF2L hypothetical protein hypothetical protein arginine n-methyltransferase hypothetical protein hypothetical protein ATP-dependent RNA helicase proteasome subunit beta type 1 long-chain fatty acid CoA ligase hypothetical protein 60S ribosomal protein L27a hypothetical protein thymidylate kinase regulator of chromosome condensation protein histone H4 hypothetical protein, conserved hypothetical protein DNAJ-like Sec63 homologue 60S ribosomal subunit protein L18 nucleoside transporter 1 hypothetical protein ribosomal protein L7a hypothetical protein hypothetical protein, conserved 60S ribosomal protein L26 T-complex protein 1 epsilon subunit protein kinase hypothetical protein 1.11 0.72 0.97 1.06 1.24 0.28 1.02 0.65 0.99 0.74 1.14 1.02 1.21 1.26 1.22 1.28 1.63 1.52 1.80 1.90 2.02 2.95 1.53 1.60 9.62 2.09 3.40 1.50 1.69 1.69 3.11 2.52 1.82 1.86 4.88 1.49 2.34 2.94 1.45 1.34 1.84 1.47 8.46 1.31 1.60 31.43 1.86 1.31 1.58 1.61 2 1 10 1 1 5 3 2 3 2 3 6 1 3 3 2 2 3 3 3 1 4 8 1 1 2 2 4 1 4 2 2 8 3 2 4 8 2 1 5 4 2 1 5 7 1 1 6 1 3 3.40 1.78 1.51 1.86 1.65 5.11 1.55 1.61 1.61 1.66 1.50 1.51 1.52 5.76 1.74 1.65 0.94 0.96 1.28 1.11 0.83 1.02 1.12 1.29 0.81 0.89 0.84 1.11 0.98 1.12 0.84 0.89 1.05 1.17 1.05 2.28 2.56 1.37 1.56 1.43 1.45 1.49 1.59 1.48 1.68 26.16 1.33 1.55 1.45 2.15 3 2 7 2 1 5 4 2 2 2 3 6 1 4 2 3 1 5 4 1 8 4 11 1 1 2 1 2 2 4 3 3 6 3 2 4 12 3 1 6 4 2 3 4 6 1 1 2 1 2 Table 2. Regulated proteins in artemisinin and in chloroquine treated cells. Drug Induced Proteome Changes RATIO Arte Peptides Arte RATIO CQ Peptides CQ PLoS ONE | www.plosone.org 5 December 2008 | Volume 3 | Issue 12 | e4098