GSK-3 Inhibition Ameliorates Ab Pathology Figure 7. Expression of the dominant negative mutant Shaggy S9E in the adult nervous system extends the median and maximum lifespan of Arctic Ab42 flies. (A). Survival curves of flies co-expressing Arctic Ab42 and SggS9E are depicted and data were compared using the log-rank test. P,0.001 comparing UAS-ArcAb42/+;elavGS/UAS-SggS9E +RU flies to UAS-ArcAb42/UAS-gfp;elavGS/+ +RU controls. No significant PLoS Genetics | www.plosgenetics.org 9 September 2010 | Volume 6 | Issue 9 | e1001087