Table 1: Clinical, hemodynamic, and echocardiographic features of all patients and patient subgroups. Outcomes∗, no (n = 197) Outcomes, yes (n = 25) P value† Cardiology Research and Practice Variables Age, year Men Body mass index, kg/m2 Hypertension Diabetes Dyslipidemia Previous myocardial infarction Previous coronary revascularization Coronary revascularization after the index cardiac catheterization Serum creatinine, mg/dL Medications Angiotensin converting enzyme inhibitors/angiotensin receptor blockers β-blocker Calcium blocker Statin Antiplatelet agents Number of coronary arteries narrowed‡ 0 1 >1 Heart rate, beat/min Systolic aortic pressure, mmHg Diastolic aortic pressure, mmHg Left ventricular end-diastolic pressure, mmHg Relaxation time constant (Tau), ms Left ventricular end-diastolic volume index, mL/m2 Left ventricular end-systolic volume index, mL/m2 Ejection fraction Echocardiographic indices E/A Deceleration time, ms e cm/s E/e Left ventricular mass index, g/m2¶ All patients (n = 222) 67 ± 8 78% 24.1 ± 3.2 49% 40% 86% 60% 46% 23% 0.84 ± 0.20 43% 41% 32% 58% 81% 25% 26% 49% 68 ± 12 139 ± 25 68 ± 11 14.4 ± 5.4 46.4 ± 9.1 85.2 ± 21.0 34.0 ± 19.2 62 ± 13% 0.84 ± 0.41 211 ± 50 7.0 ± 2.0 9.6 ± 3.3 108.6 ± 27.6 Data are expressed as the mean ± standard deviation or frequency. ∗Outcomes were deﬁned as cardiac death (acute myocardial infarction, heart failure, and sudden cardiac death) or unscheduled admission for cardiovascular causes. †Outcomes yes versus no. ‡Narrowed coronary artery was deﬁned as major epicardial artery with ≥75% stenosis on angiogram. ¶Left ventricular mass was available in 152 patients. in Table 1. Compared with patients who survived without cardiovascular hospitalization during the followup, those who died or were hospitalized due to cardiovascular causes were more likely to be older, to be prescribed statins, and to have higher levels of Tau and lower levels of e and were less likely to have hypertension. Based on receiver-operating characteristic analyses for the prediction of death or cardiovascular hospitalization, the best cut-oﬀ points for e and E/e were determined as 5.8 cm/s (sensitivity 56%, speciﬁcity 73%, likelihood ratio 2.06) and 13.2 (sensitivity 20%, speciﬁcity 88%, likelihood ratio 1.69), respectively. Among LV function indices, sig- niﬁcant univariate predictors for death or cardiovascular hospitalization included Tau > 48 ms (HR [95% CI] = 2.57 [1.13–5.81], P < 0.05) and e < 5.8 cm/s (3.47 [1.57–7.70], P < 0.01). In contrast, no signiﬁcant predictive value was 66 ± 8 79% 24.1 ± 3.3 52% 39% 84% 59% 45% 22% 0.84 ± 0.20 45% 42% 34% 56% 80% 26% 24% 49% 68 ± 12 139 ± 25 69 ± 11 14.3 ± 5.2 46.0 ± 9.1 84.5 ± 21.4 33.5 ± 19.4 62 ± 13% 0.84 ± 0.42 213 ± 51 7.1 ± 2.1 9.5 ± 3.4 107.2 ± 26.9 71 ± 7 76% 24.3 ± 2.8 29% 50% 96% 68% 56% 32% 0.86 ± 0.20 32% 38% 20% 79% 92% 12% 40% 48% 65 ± 12 140 ± 21 65 ± 11 15.0 ± 5.9 49.5 ± 8.4 90.1 ± 22.7 37.6 ± 18.0 60 ± 11% 0.82 ± 0.34 200 ± 45 6.4 ± 1.7 10.0 ± 2.8 121.6 ± 30.9 <0.01 NS NS <0.05 NS NS NS NS NS NS NS NS NS <0.05 NS NS NS NS NS NS 0.06 NS NS NS NS NS 0.06 NS 0.05 3