Nucleic Acids Research, 2009, Vol. 37, Web Server issue W55 Figure 1. (A) Snapshot of the SIB-BLAST front page. The main section allows the user to submit the query protein sequence either by pasting in the window or by uploading a ﬁle. Dropdown menus allow the user to choose the number of rounds and the maximal number of target sequences. A brief explanation of each of these input parameters can be obtained by clicking the HELP link. Links to the Help manual and a downloadable SIB package are included on the front page. (B) Snapshot of the SIB-BLAST result page. The list of hits is displayed and rank-ordered by its corresponding FOM, along with its E-value at round two and at ﬁnal round. Users can access the corresponding annotation of each hit by clicking the hit’s GI number.