1436 Study Table 1 Overview of of studies on MRI-guided FUS ablation of breast tumours Tumours Breast tumour characteristics (n) Outcome of the ablation procedure 1 Hynynen et al. (2001) [39] 11 2 Huber et al. (2001) [40] 1 3 Gianfelice et al. (2003) [42] 17 4 Gianfelice et al. (2003) [46] 24 5 Gianfelice et al. (2003) [41] 12 6 Zippel et al. (2005) [43] 10 7 Khiat et al. (2006) [44] 26 8 Furusawa et al. (2006) [45] 30 9 Furusawa et al. (2007) [47] 21 - Fibroadenomas - No surgical resection - Eight lesions (73%) demonstrated complete or partial lack of contrast uptake (success) - Three lesions (27%) showed no marked decrease of contrast uptake (failure) - Invasive ductal carcinoma (n=1) - Surgical resection In the treated part of the tumour, cells were partly necrotic and mostly sublethally damaged No exact percentage is provided - Invasive ductal carcinoma (n=14) - Surgical resection - Adenocarcinoma (n=2) - Complete necrosis in four lesions (24%) - Infiltrating lobular carcinoma (n=1) - Less than 10% residual tumour in nine lesions (52%) - All tumours <3.5 cm in size - Between 30–75% residual tumour in four lesions (24%) - Breast neoplasms, not specified - No surgical resection - All tumours <2.5 cm in size - Complete necrosis after 1 or 2 treatments in 19 lesions (79%) - Residual tumour after two treatments (failure) in five lesions (21%) - Invasive ductal carcinoma (n=11) - Surgical resection - Adenocarcinoma (n=1) - Tumour necrosis 43.2% in three lesions (treated with old FUS system) - All tumours <3.5 cm in size - 88.3% tumour necrosis in nine lesions (treated with new FUS system) - Breast neoplasms, not specified - Surgical resection - All tumours <3 cm in size - Complete necrosis in two lesions (20%) - Microscopic foci of residual tumour in two lesions (20%) - 10% residual tumour in three lesions (30%) - Between 10–30% residual tumour in three lesions (30%) - Invasive ductal carcinoma (n=25) - Surgical resection - Infiltrating lobular carcinoma (n=1) - Complete necrosis in seven lesions (27%) - All tumours <3.5 cm in size - Less than 10% residual tumour in 11 lesions (42%) - Between 20–90% residual tumour in seven lesions (27%) - Outcome of one lesion is missing (4%) - Invasive ductal carcinoma (n=26) - Surgical resection - Ductal carcinoma in situ (n =3) - Mean necrosis of targeted breast tumours was 96.9% - Invasive mucinous carcinoma (n=1) - Complete necrosis in 15 lesions (50%) - All tumours <3 cm in size - Between 95%-100% necrosis in 12 lesions (36%) - Less than 95% necrosis in three lesions (4%) - Breast neoplasms, not specified - No surgical resection - All tumours <5 cm in size - Mean follow-up 14 months (range 3–26 months) - Complete necrosis in 20 lesions (95%) - One recurrence (5%)