4 Journal of Environmental and Public Health Table 2: RBC mercury concentration and serum EPA and HDL-EPA levels in association with weekly ﬁsh consumption. <2 Weekly ﬁsh consumption∗1 3-4 5-6 >7 P for trend∗2 Hg levels in RBC Men N 14 34 23 21 Mean Hg∗3 (ng/g) 50.1 41.7 35.7 51.9 0.643 95% CI 35.0–71.7 32.2–53.8 26.5– 48.3 38.1–70.8 Women N 21 79 45 20 Mean Hg∗3 (ng/g) 22.1 25.2 24.1 35.1 0.035 95% CI 15.9–30.7 21.2–30.1 19.5– 29.7 26.1–47.2 Serum EPA levels Men N 14 34 23 21 Mean EPA∗3 (mg/L) 55.9 74.5 68.3 78.2 0.207 95% CI 36.5–85.8 54.9–101.2 47.8–97.7 54.0– 113.2 Women N 21 79 45 20 Mean EPA∗3 (mg/L) 59.0 57.5 60.6 63.2 0.582 95% CI 45.8–75.8 50.7–65.3 52.1–70.4 51.2–78.0 EPA levels in serum HDL fraction Men N 14 34 23 21 Mean∗3 (mg/L) 21.2 23.5 29.6 33.2 0.014 95% CI 14.1–31.8 17.6–31.5 21.0–41.8 23.3–47.3 Women N 21 79 45 20 Mean∗3 (mg/L) 17.9 21.4 22.8 25.0 0.073 95% CI 13.5–23.7 18.6–24.7 19.3–27.0 19.8–31.5 ∗1 : Raw ﬁsh (times/week) + ﬁsh-paste products (times/week) + dry-ﬁsh (times/week). ∗2: When calculating P values, age was always included in the models as a covariate. Trend of association was assessed by a regression model assigning consecutive integers to the levels of the weekly ﬁsh consumption. ∗3: Geometric mean. Table 3: Total mercury concentration (ng/g) in red blood cells by EPA and HDL-EPA levels. EPA levels in sera (mg/L) <40 40– 60– 80+ EPA levels in HDL fraction of sera (mg/L) <15 15– 25– 35+ N 26 27 11 33 23 26 12 34 Men RBC Hg levels Mean∗1 (ng/g) 95% CI 39.0 28.3–53.8 33.1 24.6–44.6 54.7 38.9–76.9 44.9 34.5–58.4 P for trend∗2 = 0.149 43.8 31.6–60.7 39.8 29.8–53.2 45.7 31.1–67.2 46.1 35.4–60.2 P for trend∗2 = 0.568 N 36 55 46 32 32 78 30 30 Women RBC Hg levels Mean∗1 (ng/g) 95% CI 21.2 16.6–27.0 24.7 20.2–30.4 27.2 22.1–33.4 33.1 25.7–42.5 P for trend∗2 = 0.005 21.6 17.0–27.4 24.2 20.3–28.8 31.8 24.6–41.0 35.1 27.2–45.4 P for trend∗2 = 0.001 ∗1 : Geometric mean. ∗2: When calculating P values, age was always included in the models as a covariate. The continuous P for trend was calculated by treating the EPA level as a continuous variable.