Hindawi Publishing Corporation Thrombosis Volume 2012, Article ID 367823, 6 pages doi:10.1155/2012/367823 Research Article Lack of Association between Recurrent Pregnancy Loss and Inherited Thrombophilia in a Group of Colombian Patients Henry Cardona,1, 2 Serguei A. Castan˜ eda,1, 2 W a´lter Cardona Maya,1, 2 Leonor Alvarez,2 Joaquı´n G o´mez,3 Jorge G o´mez,3 Jose´ Torres,2 Luis Tob o´n,2 Gabriel Bedoya,4 and A´ ngela P. Cadavid1, 2 1 Grupo Reproduccio´n, Universidad de Antioquia, Medell´ın, Colombia 2 Grupo de Estudio en Trombosis, Universidad de Antioquia, Medell´ın, Colombia 3 Departamento de Ginecolog´ıa y Obstetricia, Universidad de Antioquia and Hospital Universitario San Vicente de Pau´l, Medell´ın, Colombia 4 GENMOL, Universidad de Antioquia, Medell´ın, Colombia Correspondence should be addressed to A´ ngela P. Cadavid, angelap.cadavid@gmail.com Received 9 November 2011; Accepted 27 January 2012 Academic Editor: Solaf Elsayed Copyright © 2012 Henry Cardona et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Studies have shown an association between recurrent pregnancy loss and inherited thrombophilia in Caucasian populations, but there is insuﬃcient knowledge concerning triethnic populations such as the Colombian. The aim of this study was to evaluate whether inherited thrombophilia is associated with recurrent pregnancy loss. Methods. We conducted a case-control study of 93 patients with recurrent pregnancy loss (cases) and 206 healthy multiparous women (controls) in a Colombian subpopulation. Three single nucleotide polymorphisms (SNPs) markers of the inherited thrombophilias factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T were genotyped by PCR-RFLP. Activated protein C resistance and plasma levels of antithrombin, protein C, and protein S were also measured. Results. The frequency of thrombophilia-associated SNPs, activated protein C resistance, and anticoagulant protein deﬁciencies, was low overall, except for the methylenetetrahydrofolate reductase C677T SNP. The diﬀerences between patients and controls had no statistical signiﬁcance. Conclusion. Our study conﬁrms the low prevalence of inherited thrombophilias in non-Caucasian populations and it is unlikely that the tested thrombophilias play a role in the pathogenesis of recurrent pregnancy loss in this Colombian population. 1. Introduction Pregnancy is an acquired hypercoagulable state and women with a prior tendency to thrombosis may develop clini- cal symptoms of placental vascular complications such as preeclampsia, intrauterine growth restriction, and fetal death for unknown causes, that impact the maternal-fetal mor- bidity and mortality [1–4]. Recurrent pregnancy loss is an important obstetric complication with a prevalence of 1– 5% [5]. Inherited thrombophilia has been postulated as a cause of recurrent pregnancy loss, although the association between inherited thrombophilia and recurrent pregnancy loss has not been conclusively established. Some studies have demonstrated an association between recurrent pregnancy loss and prothrombotic states rendered by some genetic single nucleotide polymorphisms (SNPs), such as factor V Leiden G1691A (FV Leiden), prothrombin G20210A (FII G20210A), and methylenetetrahydrofolate reductase C677T (MTHFR C677T), and activated protein C resistance (APC resistance) [6–14], whereas others have reported lack of any association [15–19]. In addition, a retrospective cohort study showed that women with deﬁciencies of antithrombin (AT), protein C (PC), or protein S (PS) have an eightfold increased relative risk of thrombosis during pregnancy compared to controls [20]. Most of the studies on thrombophilia and recurrent pregnancy loss have been conducted in Caucasian popu- lations [21, 22]. Therefore, the association between these