W230 Nucleic Acids Research, 2006, Vol. 34, Web Server issue In addition, sgTarget has been employed to select a set of Bacillus anthracis target proteins for the SPINE consortium. Here, the resource was used in tandem with the bioinformatics tools available at the Oxford Protein Production Facility (http://www.oppf.ox.ac.uk/bioinformatics.php) to select a set of proteins of desirable molecular weight (20 to 55 kDa), which are likely to be soluble (insolubility probability smaller than 0.7) (17). We encourage structural biologists to submit sequence datasets to sgTarget and contact us regarding suggestions on software and databases for the annotation pipeline, the annotation views provided by sgTarget and the functionality of the Target page. ACKNOWLEDGEMENTS We would like to thank the authors and curators of the software and databases used in this work. A.R. was supported by a grant to the York Structural Biology Centre by Accelrys Inc, San Diego. 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