6704 Nucleic Acids Research, 2006, Vol. 34, No. 22 PF07_0003 Rifin Figure 6. A locus containing a central Pfmc-2TM gene that is duplicated 13 times in the P.falciparum 3D7 isolate genome sequence. (A) The predicted length (Kb) of locus duplication, determined as nucleotide identities shared with the extended PFF1525c locus (upper row, indicated by an open rectangle). The left- hand columns indicate for each locus the predicted chromosome and telomere location (left, L; right, R); orientation (sense, S; antisense, AS); and Pfmc-2TM gene identifier. Adjacent loci are indicated by a gray star (Chr2, R) and black star (Chr11, L). A vertical dashed line, at approximately the 12.4 Kb mark, indicates the location of the Pfmc-2TM gene within each locus. Gray horizontal bars indicate >85% nt identity with the PFF1525c locus, and black horizontal bars indicate >95% identity. The curly brackets unify additional sequence similarities (dashed gray bars) that are specific to PF11_0025 and PF10_0390; PF11_0014 and MAL8P1.213; and PFA0065w, PF11_0014 and MAL8P1.213. (B) Predicted ORFs within the 13 loci extending 12 Kb upstream and 20 Kb downstream of each centralized Pfmc-2TM gene. ORFs on the sense strand are shown in gray, and ORFs on the antisense strand are in black. All ORFs encode Pexel/VTS-containing genes, var genes or predicted pseudogenes.