288 Region Desipramine PCX CCX HIP Citalopram PCX CCX HIP AMY DMI repeated Psychopharmacology (2012) 223:281–297 Table 1 Genes with expression profiles most closely approximating the SVD modes after treatment with DMI (top) and CIT (bottom) in the PCX, CCX, HIP, and AMY Datasets were sorted by the administered drug and brain region. Gene expression values for each time point (0, 1, 3, 7, 14, and 21 days) were arranged into a time series specific for each treatment type (repeated and acute). Genes for which the expression profiles over time most closely approximated the global expression (SVD modes) are listed for DMI (top) and CIT (bottom) treatment Treatment DMI repeated DMI single-dose DMI repeated DMI single-dose DMI repeated DMI single-dose DMI single-dose CIT single-dose CIT repeated CIT single-dose CIT repeated CIT single-dose Mode Mode 1 Mode 2 Mode 1 Mode 2 Mode 3 Mode 1 Mode 2 Mode 1 Mode 2 Mode 3 Mode 1 Mode 2 Mode 3 Mode 1 Mode 2 Mode 3 Mode 1 Mode 2 Mode 1 Mode 2 Mode 3 Mode 1 Mode 2 Mode 1 Mode 2 Mode 1 Mode 2 Mode 1 Mode 2 Mode 3 Mode 1 Mode 2 Gene symbol Akr1a1, Bcl2, Cacna1a, Crhbp, Ctcf, Egr1, Gria2, Hdac1, Id1, Jund, Ntrk2, Penk1, Ppia, Scn2a1, Sst, Stat3, Tparl,Yy1 Adra2a, Cebpb, Cplx2, Dbp, Gria3, Pir Adra1d, Adra2a, Arnt, Atp6v0c, Cnr1, Creb1, Crhbp, Crhr1, Ctcf, Egr1, Gria1, Gria2, Npy, Ppia, S100a10, Sp1, Sst, Tparl, Yy1 Fos Nr4a1, Penk1 Adra2a, Cplx2 Adrb1, Arrb2, Dbp, Hdac1, Hdac3, Id1, Penk1 Atp6v0c, Cplx2, Crhbp, Drd1ip, Egr1, Fos, Gria1, Htr2c, Nr4a1, Sst Adrb1, Arrb2, Hdac1, Penk1 Adra2a, Hdac5 Adra1d, Adrb1, Akr1a1, Arnt, Atp6v0c, Dbp, Egr1, Ets1, Gria2, Hdac3, Npy2r, Ppia, Stat3 Cacna1a, Fos, Id1, Penk1 Bcl2, Nr4a1 Adrb1, Atp6v0c, Cdk5, Cplx2, Crhbp, Drd1ip, Egr1, Ets1, Galr2, Gria2, Gria3, Hdac3, Htr1a, Id3, Il1r1, Jun, Jund, Ndrg2, Npy2r Akt1, Galr3, Npy Id1 Adrb1, Aes, Akr1a1, Atp6v0c, Cdk5, Cebpb, Crhbp, Crhr1, Gria1, Gria2, Gria3, Hdac3, Hdac5, Nr2f2, Ntrk2, Ppia Akt1, Fos, Nr4a1, Nr4a2, Oprk1 Adra2c, Adrb1, Aes, Akr1a1, Akt1, Arrb1, Atp6v0c, Bcl2, Bdnf, Cacna1a, Cdk5, Cnr1, Crhr1, Dbp, Drd1ip, Egr1, Ets1, Fos, Galr1, Gap43, Gria3, Hdac1, Hdac3, Htr2c, Id1, Il1r1, Il6, Jund, Nr4a1, Ntrk2, Oprk1, Pax6, Penk1, Pomc, Rxra, S100a10, Scn2a1, Sst, Tparl Hdac5, Ndrg2, Nr4a2, Ppia Gria1, Gria2, Id3, Ntf3, Stat5a Adrb2, Cdk5, Cnr1, Ets1, Fos, Gap43, Hdac1, Hspb1, Htr2c, Id1, Id3, Il6ra, Nr4a1, Pax6, Ppia, Rxra, S100a10, Stat1 Cplx1 Egr1, Fos, Nr4a1 Ntf3, S100a10, Stat1 Adra2c, Arnt, Drd2, Egr1, Ets1, Fos, Galr2, Gata2, Htr2c, Id1, Id3, Jun, Nr4a1 Arrb2, Drd1ip, Esr2, Grip2 Id3, Ndrg2, Npy, Plat, Pnoc, Ppia, Scn2a1, Stat1, Tparl, Yy1 Arrb2, Galr3 Ets1, Npy2r Ets1, Fos, Gria3, Htr1a, Id1, Id3, Il6ra, Jun, Nr2f2, Nr4a1, Plat, Pnoc, Rxra, Sp1, Stat1 Drd2, Sst