Nucleic Acids Research, 2012, Vol. 40, Web Server issue W611 Figure 1. Schema of CellBase architecture of RESTful web services. access to disk. CellBase Apache Tomcat instances are running in a cluster with three high-end servers with an Intel Xeon Quad-Core and 6GB of memory each. ‘cloud’-based applications or companies in which heavy data are not moved through the web and is always up-to-date available by RESTful web services API. DATA ISSUES IN BIOLOGY Biology is experiencing an unprecedented growth of data and resources, what is making very difﬁcult the access to local or conventional databases. New ‘cloud computing’ paradigm allows storing big data in remote servers and using web services to access and retrieve data efﬁciently. By doing so, researchers do not need to download, parse or integrate different sources since data are always up-to-date and can be retrieved by different client appli- cations. Here, we follow a philosophy similar to some WEB SERVICES The CellBase RESTful web services API is an intuitive collection of methods that allow the user searching and retrieving biological data in a user-friendly way. RESTful calls are easily accessed using Universal Resource Locators (URLs), reducing the access to biological infor- mation to a simple browser query. Output results can be retrieved in text or JSON formats. Today, all programming languages can handle URLs, what makes CellBase biological information fully accessible in