1185 Fig. 2 Volume-rendered display showing three repeated measure- ments of a sub-centimetre intra-parenchymal pulmonary nodule with reconstruction settings A (top), B (middle) and C (bottom). Nodule measurements are completely identical with setting A (40.3 mm3), slightly different with setting B (32.9, 32.9, 33.0 mm3) and moderately different with setting C (39.1, 42.2, 41.1 mm3). The means of measured volume with settings A and C were larger than 3 with setting B (40.3 vs 32.9 vs 40.8 mm ) is equivalent to the soft kernel in our study [22]. The results of Honda et al. are in accordance with our results and demonstrate that a sharp kernel leads to a larger mean measured volume than a soft kernel. This can be explained by the fact that the spatial resolution in the X-Y plane increases when a sharp kernel is used and mild irregula- rities are included in the segmentation, which increases the measured volume (Fig. 2). The effect of reconstruction