296 Le-Niculescu H, McFarland MJ, Ogden CA, Balaraman Y, Patel S, Tan J, Rodd ZA, Paulus M, Geyer MA, Edenberg HJ, Glatt SJ, Faraone SV, Nurnberger JI, Kuczenski R, Tsuang MT, Niculescu AB (2008) Phenomic, convergent functional genomic, and bio- marker studies in a stress-reactive genetic animal model of bipolar disorder and co-morbid alcoholism. Am J Med Genet B Neuro- psychiatr Genet 147B(2):134–166 Leonard BE, Myint A (2009) The psychoneuroimmunology of depres- sion. Hum Psychopharmacol 24:165–175 LopezMolina L, Conquet F, DuboisDauphin M, Schibler U (1997) The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior. EMBO J 16:6762–6771 Machado-Vieira R, Salvadore G, DiazGranados N, Ibrahim L, Latov D, Wheeler-Castillo C, Baumann J, Henter ID, Zarate CA Jr (2010) New therapeutic targets for mood disorders. Scientific- WorldJournal 10:713–726 Maes M, Yirmiya R, Noraberg J, Brene S, Hibbeln J, Perini G, Kubera M, Bob P, Lerer B, Maj M (2009) The inflammatory & neurode- generative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression. Metab Brain Dis 24:27–53 Martinez-Turrillas R, Frechilla D, Del Rio J (2002) Chronic antide- pressant treatment increases the membrane expression of AMPA receptors in rat hippocampus. Neuropharmacology 43:1230–1237 Milbrandt J (1987) A nerve growth factor-induced gene encodes a pos- sible transcriptional regulatory factor. Science 238(4828):797–799 Mirnics K, Middleton FA, Lewis DA, Levitt P (2001) Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse. Trends Neurosci 24:479–486 Mitchell AJ (2006) Two-week delay in onset of action of antidepres- sants: new evidence. Br J Psychiatry 188:105–106 Morinobu S, Nibuya M, Duman RS (1995) Chronic antidepressant treatment down-regulates the induction of c-fos mRNA in re- sponse to acute stress in rat frontal cortex. Neuropsychopharma- cology 12:221–228 Neumaier JF, Root DC, Hamblin MW (1996) Chronic fluoxetine reduces serotonin transporter mRNA and 5-HT1B mRNA in a sequential manner in the rat dorsal raphe nucleus. Neuropsycho- pharmacology 15:515–522 Nibuya M, Morinobu S, Duman RS (1995) Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci 15 (11):7539–7547 Nibuya M, Nestler EJ, Duman RS (1996) Chronic antidepressant administration increases the expression of cAMP response ele- ment binding protein (CREB) in rat hippocampus. J Neurosci 16 (7):2365–2372 Niculescu AB III, Segal DS, Kuczenski R, Barrett T, Hauger RL, Kelsoe JR (2000) Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach. Physiol Genomics 4:83–91 Okugawa G, Omori K, Suzukawa J, Fujiseki Y, Kinoshita T, Inagaki C (1999) Long-term treatment with antidepressants increases gluco- corticoid receptor binding and gene expression in cultured rat hippocampal neurones. J Neuroendocrinol 11:887–895 Orsetti M, Di Brisco F, Canonico PL, Genazzani AA, Ghi P (2008) Gene regulation in the frontal cortex of rats exposed to the chronic mild stress paradigm, an animal model of human depression. Eur J Neurosci 27:2156–2164 Ostrowski J, Wyrwicz LS (2009) Integrating genomics, proteomics and bioinformatics in translational studies of molecular medicine. Expert Rev Mol Diagn 9:623–630 Palotas M, Palotas A, Puskas LG, Kitajka K, Pakaski M, Janka Z, Molnar J, Penke B, Kalman J (2004) Gene expression profile Psychopharmacology (2012) 223:281–297 analysis of the rat cortex following treatment with imipramine and citalopram. Int J Neuropsychopharmacol 7:401–413 Park HG, Kim SH, Kim HS, Ahn YM, Kang UG, Kim YS (2011) Repeated electroconvulsive seizure treatment in rats reduces in- ducibility of early growth response genes and hyperactivity in response to cocaine administration. Prog Neuropsychopharmacol Biol Psychiatry 35:1014–1021 Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates. Academic Press, San Diego Pfaffl MW (2001) A new mathematical model for relative quantifica- tion in real-time RT-PCR. Nucleic Acids Res 29(9) Piechota M, Korostynski M, Przewlocki R (2010) Identification of cis- regulatory elements in the mammalian genome: the cREMaG database. PLoS One 5(8) Pineyro G, Blier P (1999) Autoregulation of serotonin neurons: role in antidepressant drug action. Pharmacol Rev 51:533–591 Ploski JE, Newton SS, Duman RS (2006) Electroconvulsive seizure- induced gene expression profile of the hippocampus dentate gyrus granule cell layer. J Neurochem 99:1122–1132 Pustylnik S (2011) Experimental verification of myocyte enhancer factor 2 (MEF2) and serum response factor (SRF) interaction predicted by computational methods. Dissertation, Canada York University. Redrobe JP, Dumont Y, Quirion R (2002) Neuropeptide Y (NPY) and depression: from animal studies to the human condition. Life Sci 71:2921–2937 Ressler KJ, Mayberg HS (2007) Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic. Nat Neurosci 10:1116–1124 Rodd ZA, Bertsch BA, Strother WN, Le-Niculescu H, Balaraman Y, Hayden E, Jerome RE, Lumeng L, Nurnberger JI Jr, Edenberg HJ, McBride WJ, Niculescu AB (2007) Candidate genes, pathways and mechanisms for alcoholism: an expanded convergent func- tional genomics approach. Pharmacogenomics J 7:222–256 Schlesinger J, Schueler M, Grunert M, Fischer JJ, Zhang Q, Krueger T, Lange M, Tönjes M, Dunkel I, Sperling SR (2011) The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs. Plos Genet 7(2) Sillaber I, Panhuysen M, Henniger MSH, Ohl F, Kuhne C, Putz B, Pohl T, Deussing JM, Paez-Pereda M, Holsboer F (2008) Profiling of behavioral changes and hippocampal gene expression in mice chronically treated with the SSRI paroxetine. Psychopharmacol- ogy 200:557–572 Simek K, Fujarewicz K, Swierniak A, Kimmel M, Jarzab B, Wiench M, Rzeszowska J (2004) Using SVD and SVM methods for selection, classification, clustering and modeling of DNA micro- array data. Eng Appl Artif Intell 17:417–427 Slattery DA, Morrow JA, Hudson AL, Hill DR, Nutt DJ, Henry B (2005) Comparison of alterations in c-fos and Egr-1 (zif268) expression throughout the rat brain following acute administration of different classes of antidepressant compounds. Neuropsycho- pharmacology 30:1278–1287 Stahlberg A, Elbing K, Andrade-Garda JM, Sjogreen B, Forootan A, Kubista M (2008) Multiway real-time PCR gene expression profil- ing in yeast Saccharomyces cerevisiae reveals altered transcriptional response of ADH-genes to glucose stimuli. BMC Genomics 9:170 Surget A, Wang Y, Leman S, Ibarguen-Vargas Y, Edgar N, Griebel G, Belzung C, Sibille E (2009) Corticolimbic transcriptome changes are state-dependent and region-specific in a rodent model of depression and of antidepressant reversal. Neuropsychopharma- cology 34:1363–1380 Takahashi Y, Washiyama K, Kobayashi T, Hayashi S (2006) Gene expression in the brain from fluoxetine-injected mouse using DNA microarray. Ann N Y Acad Sci 1074:42–51 Tanti A, Belzung C (2010) Open questions in current models of antidepressant action. Br J Pharmacol 159:1187–1200