6 [45] D. S. Bredt, P. M. Hwang, and S. H. Snyder, “Localization of nitric oxide synthase indicating a neural role for nitric oxide,” Nature, vol. 347, no. 6295, pp. 768–770, 1990. [46] S. R. Vincent and H. Kimura, “Histochemical mapping of nitric oxide synthase in the rat brain,” Neuroscience, vol. 46, no. 4, pp. 755–784, 1992. [47] C. J. Tseng, H. Y. Liu, H. C. Lin, L. P. Ger, C. S. Tung, and M. H. Yen, “Cardiovascular eﬀects of nitric oxide in the brain stem nuclei of rats,” Hypertension, vol. 27, no. 1, pp. 36–42, 1996. [48] M. Barinaga, “Is nitric oxide the ’retrograde messenger’?” Science, vol. 254, no. 5036, pp. 1296–1297, 1991. [49] H. Togashi, I. Sakuma, M. Yoshioka et al., “A central nervous system action of nitric oxide in blood pressure regulation,” Journal of Pharmacology and Experimental Therapeutics, vol. 262, no. 1, pp. 343–347, 1992. [50] S. Harada, S. Tokunaga, M. Momohara et al., “Inhibition of nitric oxide formation in the nucleus tractus solitarius increases renal sympathetic nerve activity in rabbits,” Circu- lation Research, vol. 72, no. 3, pp. 511–516, 1993. [51] S. Ye, S. Nosrati, and V. M. Campese, “Nitric oxide (NO) modulates the neurogenic control of blood pressure in rats with chronic renal failure (CRF),” Journal of Clinical Investigation, vol. 99, no. 3, pp. 540–548, 1997. [52] A. Terao, M. Oikawa, and M. Saito, “Tissue-speciﬁc increase in norepinephrine turnover by central interleukin-1, but not by interleukin-6, in rats,” American Journal of Physiology, vol. 266, no. 2, part 2, pp. R400–R404, 1994. [53] S. Liu, I. M. Adcock, R. W. Old, P. J. Barnes, and T. W. Evans, “Lipopolysaccharide treatment in vivo induces widespread tissue expression of inducible nitric oxide synthase mRNA,” Biochemical and Biophysical Research Communications, vol. 196, no. 3, pp. 1208–1213, 1993. [54] A. Niijima, T. Hori, S. Aou, and Y. Oomura, “The eﬀects of interleukin-1β on the activity of adrenal, splenic and renal sympathetic nerves in the rat,” Journal of the Autonomic Nervous System, vol. 36, no. 3, pp. 183–192, 1991. [55] M. Shibata, H. Parfenova, S. L. Zuckerman, J. M. Seyer, J. M. Krueger, and C. W. Leﬄer, “Interleukin-1ß peptides induce cerebral pial arteriolar dilation in anesthetized newborn pigs,” American Journal of Physiology, vol. 270, no. 5, pp. R1044– R1050, 1996. [56] S. Ye, P. Mozayeni, M. Gamburd, H. Zhong, and V. M. Campese, “Interleukin-1β and neurogenic control of blood pressure in normal rats and rats with chronic renal failure,” American Journal of Physiology, vol. 279, no. 6, pp. H2786– H2796, 2000. [57] H. Jin, R. H. Yang, J. M. Wyss, Y. F. Chen, and S. Oparil, “Intrahypothalamic clonidine infusion prevents NaCl- sensitive hypertension,” Hypertension, vol. 18, no. 2, pp. 224– 229, 1991. [58] T. Dorman, K. Clarkson, B. A. Rosenfeld, C. Shanholtz, P. A. Lipsett, and M. J. Breslow, “Eﬀects of clonidine on prolonged postoperative sympathetic response,” Critical Care Medicine, vol. 25, no. 7, pp. 1147–1152, 1997. [59] V. M. Campese, M. Romoﬀ, and N. Telfer, “Role of sym- pathetic nerve inhibition and body sodium-volume state in the antihypertensive action of clonidine in essential hyperten- sion,” Kidney International, vol. 18, no. 3, pp. 351–357, 1980. [60] V. M. Campes, D. Levitan, M. S. Romoﬀ, Y. Saglikes, I. Sajo, and S. G. Massry, “Eﬀect of sympa thetic nerve inhibition on the state of sodium volume balance in hypertensive pa-tients with normal or impaired renal function,” Clinical Science, vol. 63, pp. 301s–303s, 1982. International Journal of Hypertension [61] V. M. Campese and S. G. Massry, “Eﬀects of acute and chronic treatment with clonidine,” Chest, vol. 83, no. 2, pp. 380s–383s, 1983. [62] M. P. Schlaich, P. A. Sobotka, H. Krum, E. Lambert, and M. D. Esler, “Renal sympathetic-nerve ablation for uncontrolled hypertension,” New England Journal of Medicine, vol. 361, no. 9, pp. 932–934, 2009. [63] H. Krum, M. Schlaich, R. Whitbourn et al., “Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study,” The Lancet, vol. 373, no. 9671, pp. 1275–1281, 2009.