Obstetrics and Gynecology International Obstetricia et Gynecologica Scandinavica, vol. 86, no. 7, pp. 855–860, 2007. [25] M. R. Khalil, P. E. Rasmussen, K. Erb, S. B. Laursen, S. Rex, and L. G. Westergaard, “Homologous intrauterine insemination. An evaluation of prognostic factors based on a review of 2473 cycles,” Acta Obstetricia et Gynecologica Scandinavica, vol. 80, no. 1, pp. 74–81, 2001. [26] M. J. Tomlinson, J. B. Amissah-Arthur, K. A. Thompson, J. L. Kasraie, and B. Bentick, “Prognostic indicators for intrauterine insemination (IUI): statistical model for IUI success,” Human Reproduction, vol. 11, no. 9, pp. 1892–1896, 1996. [27] B. J. Van Voorhis, A. E. T. Sparks, B. D. Allen, D. W. Stovall, C. H. Syrop, and F. K. Chapler, “Cost-eﬀectiveness of infertility treatments: a cohort study,” Fertility and Sterility, vol. 67, no. 5, pp. 830–836, 1997. [28] V. C. Karande, A. Korn, R. Morris, et al., “Prospective randomized trial comparing the outcome and cost of in vitro fertilization with that of a traditional treatment algorithm as ﬁrst-line therapy for couples with infertility,” Fertility and Sterility, vol. 71, no. 3, pp. 468–475, 1999. [29] A. J. Goverde, J. McDonnell, J. P. W. Vermeiden, R. Schats, F. F. H. Rutten, and J. Schoemaker, “Intrauterine insemination or in-vitro fertilisation in idiopathic subfertility and male subfertility: a randomised trial and cost-eﬀectiveness analysis,” The Lancet, vol. 355, no. 9197, pp. 13–18, 2000. [30] C. M. Peterson, H. H. Hatasaka, K. P. Jones, A. M. Poulson Jr., D. T. Carrell, and R. L. Urry, “Ovulation induction with gonadotropins and intrauterine insemination compared with in vitro fertilization and no therapy: a prospective, nonrandomized, cohort study and meta-analysis,” Fertility and Sterility, vol. 62, no. 3, pp. 535–544, 1994. [31] F. Zayed, E. A. Lenton, and I. D. Cooke, “Comparison between stimulated in-vitro fertilization and stimulated intrauterine insemination for the treatment of unexplained and mild male factor infertility,” Human Reproduction, vol. 12, no. 11, pp. 2408–2413, 1997. [32] B. J. Cohlen, P. Vandekerckhove, E. R. te Velde, and J. D. Habbema, “Timed intercourse versus intra-uterine insemina- tion with or without ovarian hyperstimulation for subfertility in men,” The Cochrane Database of Systematic Reviews, no. 4, Article ID CD000360, 2000. [33] N. Pashayan, G. Lyratzopoulos, and R. Mathur, “Cost- eﬀectiveness of primary oﬀer of IVF vs. primary oﬀer of IUI followed by IVF (for IUI failures) in couples with unexplained or mild male factor subfertility,” BMC Health Services Research, vol. 6, article 80, pp. 1–11, 2006. [34] E. G. Hughes, “The eﬀectiveness of ovulation induction and intrauterine insemination in the treatment of persistent infertility: a meta-analysis,” Human Reproduction, vol. 12, no. 9, pp. 1865–1872, 1997. [35] D. S. Guzick, S. A. Carson, C. Coutifaris, et al., “Eﬃcacy of superovulation and intrauterine insemination in the treat- ment of infertility,” The New England Journal of Medicine, vol. 340, no. 3, pp. 177–183, 1999. [36] S. M. Verhulst, B. J. Cohlen, E. Hughes, M. J. Heineman, and E. te Velde, “Intra-uterine insemination for unexplained subfertility,” The Cochrane Database of Systematic Reviews, no. 4, Article ID CD001838, pp. 1–82, 2006. [37] P. Steures, J. W. van der Steeg, P. G. Hompes, et al., “Intrauter- ine insemination with controlled ovarian hyperstimulation versus expectant management for couples with unexplained subfertility and an intermediate prognosis: a randomised 9 clinical trial,” The Lancet, vol. 368, no. 9531, pp. 216–221, 2006. [38] P. Steures, J. W. van der Steeg, P. G. A. Hompes, et al., “The additional value of ovarian hyperstimulation in intrauterine insemination for couples with an abnormal postcoital test and a poor prognosis: a randomized clinical trial,” Fertility and Sterility, vol. 88, no. 6, pp. 1618–1624, 2007. [39] NICE Guidelines: National Institute for Clinical Excellence, Fertility: Assessment and Treatment for People with Fertility Problems, RCOG Press, London, UK, 2004. [40] G. Ragni, F. Alagna, C. Brigante, et al., “GnRH antagonists and mild ovarian stimulation for intrauterine insemination: a ran- domized study comparing diﬀerent gonadotrophin dosages,” Human Reproduction, vol. 19, no. 1, pp. 54–58, 2004. [41] S. Gerli, M. L. Casini, V. Unfer, L. Costabile, V. Bini, and G. C. Di Renzo, “Recombinant versus urinary follicle-stimulating hormone in intrauterine insemination cycles: a prospective, randomized analysis of cost eﬀectiveness,” Fertility and Steril- ity, vol. 82, no. 3, pp. 573–578, 2004. [42] A. Demirol and T. Gurgan, “Comparison of diﬀerent gonadotrophin preparations in intrauterine insemination cycles for the treatment of unexplained infertility: a prospec- tive, randomized study,” Human Reproduction, vol. 22, no. 1, pp. 97–100, 2007. [43] T. Dankert, J. A. Kremer, B. J. Cohlen, et al., “A randomized clinical trial of clomiphene citrate versus low dose recom- binant FSH for ovarian hyperstimulation in intrauterine insemination cycles for unexplained and male subfertility,” Human Reproduction, vol. 22, no. 3, pp. 792–797, 2007. [44] A. E. P. Cantineau and B. J. Cohlen, “Ovarian stimulation protocols (anti-oestrogens, gonadotrophins with and without GnRH agonists/antagonists) for intrauterine insemination (IUI) in women with subfertility,” The Cochrane Database of Systematic Reviews, no. 2, Article ID CD005356, pp. 1–135, 2007. [45] M. F. Costello, “Systematic review of the treatment of ovulatory infertility with clomiphene citrate and intrauterine insemination,” Australian and New Zealand Journal of Obstet- rics and Gynaecology, vol. 44, no. 2, pp. 93–102, 2004. [46] World Health Organization, “Collection and examination of human semen,” in WHO Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction, pp. 4–33, Cambridge University Press, Cambridge, UK, 4th edition, 1999. [47] W. Ombelet, H. Vandeput, G. Van de Putte, et al., “Intrauter- ine insemination after ovarian stimulation with clomiphene citrate: predictive potential of inseminating motile count and sperm morphology,” Human Reproduction, vol. 12, no. 7, pp. 1458–1463, 1997. [48] B. J. Van Voorhis, M. Barnett, A. E. T. Sparks, C. H. Syrop, G. Rosenthal, and J. Dawson, “Eﬀect of the total motile sperm count on the eﬃcacy and cost-eﬀectiveness of intrauterine insemination and in vitro fertilization,” Fertility and Sterility, vol. 75, no. 4, pp. 661–668, 2001. [49] B. J. Cohlen, E. R. te Velde, R. J. van Kooij, C. W. N. Looman, and J. D. F. Habbema, “Controlled ovarian hyperstimulation and intrauterine insemination for treating male subfertility: a controlled study,” Human Reproduction, vol. 13, no. 6, pp. 1553–1558, 1998. [50] R. Wainer, M. Albert, A. Dorion, et al., “Inﬂuence of the number of motile spermatozoa inseminated and of their morphology on the success of intrauterine insemination,” Human Reproduction, vol. 19, no. 9, pp. 2060–2065, 2004.