Repeated treatment: Single-dose treatment: e f g h Psychopharmacology (2012) 223:281–297 287 a b c d Repeated treatment: Repeated treatment: Single-dose treatment: Single-dose treatment: Repeated treatment: Single-dose treatment: - - - Repeated treatment: Repeated treatment: Single-dose treatment: Single-dose treatment: Repeated treatment: Repeated treatment: Single-dose treatment: Single-dose treatment: differences between the repeated and single-dose DMI treat- ments were also observed for the Dbp and Id1. In the PCX and CCX, there was an expression peak for Id1 on day 3 in the PCX and CCX and on day 14 of the repeated treatment in the HIP and AMY, respectively, while its expression remained constant under the single-dose treatment. Opposite changes were observed for the Dbp gene for which expression constantly decreased during the repeated DMI treatment,