698 Csomor PA, Stadler RR, Feldon J, Yee BK, Geyer MA, Vollenweider FX (2008) Haloperidol differentially modulates prepulse inhibi- tion and P50 suppression in healthy humans stratified for low and high gating levels. Neuropsychopharmacology 33:497–512 Eysenck HJ, Eysenck SBG (1994) Manual of the Eysenck personality questionnaire: comprising the EPQ-revised (EPQ-R) & EPQ-R short scale. EdITS, San Diego, CA Filion DL, Dawson ME, Schell AM (1993) Modification of the acoustic startle-reflex eyeblink: a tool for investigating early and late attentional processes. Biol Psychol 35:185–200 First MB, Spitzer RL, Gibbon M, Williams JBW (1997) Structured clinical interview for DSM-IV—clinical version (SCID-CV) (user’s guide and interview). American Psychiatric Press, Washington, DC Giakoumaki SG, Roussos P, Frangou S, Bitsios P (2007) Disruption of prepulse inhibition of the startle reflex by the preferential D(3) agonist ropinirole in healthy males. Psychopharmacology (Berl) 194:289–295 Graham F (1975) The more or less startling effects of weak prestimuli. Psychophysiology 12:238–248 Hamidovic A, Kang UJ, de Wit H (2008) Effects of low to moderate acute doses of pramipexole on impulsivity and cognition in healthy volunteers. J Clin Psychopharmacol 28:45–51 Hutchison KE, Wood MD, Swift R (1999) Personality factors moderate subjective and psychophysiological responses to d- amphetamine in humans. Exp Clin Psychopharmacol 7:493–501 Kvernmo T, Härtter S, Burger E (2006) A review of the receptor- binding and pharmacokinetic properties of dopamine agonists. Clin Ther 28:1065–1078 Millan MJ, Maiofiss L, Cussac D, Audinot V, Boutin JA, Newman- Tancredi A (2002) Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J Pharmacol Exp Ther 303:791–804 Norris H (1971) The action of sedation on brain-stem oculomotor systems in man. Neuropharmacology 10:181–191 Piercey MF, Hoffmann WE, Smith MW, Hyslop DK (1996) Inhibition of dopamine neuron firing by pramipexole, a dopamine D3 receptor-preferring agonist: comparison to other dopamine receptor agonists. Eur J Pharmacol 312:35–44 Roussos P, Giakoumaki SG, Bitsios P (2008a) The dopamine D(3) receptor Ser9Gly polymorphism modulates prepulse inhibition of the acoustic startle reflex. Biol Psychiatry 64:235–240 Roussos P, Giakoumaki SG, Rogdaki M, Pavlakis S, Frangou S, Bitsios P (2008b) Prepulse inhibition of the startle reflex depends on the catechol O-methyltransferase Val158Met gene polymor- phism. Psychol Med 38:1651–1658 Samuels ER, Hou RH, Langley RW, Szabadi E, Bradshaw CM (2006a) Comparison of pramipexole and amisulpride on alert- ness, autonomic and endocrine functions in healthy volunteers. Psychopharmacology (Berl) 187:498–510 Samuels ER, Hou RH, Langley RW, Szabadi E, Bradshaw CM (2006b) Comparison of pramipexole and modafinil on arousal, autonomic, and endocrine functions in healthy volunteers. J Psychopharmacol 20:756–770 Samuels ER, Hou RH, Langley RW, Szabadi E, Bradshaw CM (2007) Comparison of pramipexole with and without dom- peridone co-administration on alertness, autonomic, and endocrine functions in healthy volunteers. Br J Clin Pharma- col 64:591–602 Shilling PD, Saint Marie RL, Shoemaker JM, Swerdlow NR (2008) Strain differences in the gating-disruptive effects of apomor- phine: Relationship to gene expression in nucleus accumbens signaling pathways. Biol Psychiatry 63:748–758 Psychopharmacology (2009) 205:689–698 Svensson K, Carlsson A, Huff RM, Kling-Petersen T, Waters N (1994) Behavioral and neurochemical data suggest functional differences between dopamine D2 and D3 receptors. Eur J Pharmacol 263:235–243 Swerdlow NR, Talledo J, Sutherland AN, Nagy D, Shoemaker JM (2006) Antipsychotic effects on prepulse inhibition in normal ‘low gating’ humans and rats. Neuropsychopharmacology 31:2011–2021 Swerdlow NR, Weber M, Qu Y, Light GA, Braff DL (2008) Realistic expectations of prepulse inhibition in translational models for schizophrenia research. Psychopharmacology 199:331–388 Swerdlow NR, van Bergeijk DP, Bergsma F, Weber E, Talledo J (2009) The effects of memantine on prepulse inhibition. Neuro- psychopharmacology 34:1854–1864 Swerdlow NR, Shoemaker JM, Platten A, Pitcher L, Goins J, Crain S (2003a) Heritable differences in the effects of amphetamine but not DOI on startle gating in albino and hooded outbred rat strains. Pharmacol Biochem Behav 75:191–197 Swerdlow NR, Stephany N, Wasserman LC, Talledo J, Shoemaker J, Auerbach PP (2003b) Amphetamine effects on prepulse inhibi- tion across species: replication and parametric extension. Neuro- psychopharmacology 28:640–650 Swerdlow NR, Shoemaker JM, Platten A, Pitcher L, Goins J, Auerbach PP (2004a) Heritable differences in the dopaminergic regulation of sensorimotor gating: I. Apomorphine effects on startle gating in albino and hooded outbred rat strains and their F1 and N2 progeny. Psychopharmacology 174:441–451 Swerdlow NR, Shoemaker JM, Auerbach PP, Pitcher L, Goins J, Platten A (2004b) Heritable differences in the dopaminergic regulation of sensorimotor gating: II. Temporal, pharmacologic and generational analyses of apomorphine effects on prepulse inhibition. Psychopharmacology 174:452–462 Swerdlow NR, Shoemaker JM, Crain S, Goins J, Onozuka K, Auerbach PP (2004c) Sensitivity to drug effects on prepulse inhibition in inbred and outbred rat strains. Pharmacol Biochem Behav 77:291–302 Swerdlow NR, Platten A, Kim YK, Gaudet I, Shoemaker J, Pitcher L, Auerbach P (2001) Sensitivity to the dopaminergic regulation of prepulse inhibition in rats: evidence for genetic, but not environmental determinants. Pharmacol Biochem Behav 70:219–226 Swerdlow NR, Stephany N, Shoemaker JM, Ross L, Wasserman LC, Talledo J, Auerbach PP (2002) Effects of amantadine and bromocriptine on startle and sensorimotor gating: parametric studies and cross-species comparisons. Psychopharmacology 164:82–92 Talledo JA, Sutherland Owens AN, Schortinghuis T, Swerdlow NR (2009) Amphetamine effects on startle gating in normal women and female rats. Psychopharmacology 204:165–175 Vollenweider FX, Barro M, Csomor PA, Feldon J (2006) Clozapine enhances prepulse inhibition in healthy humans with low but not with high prepulse inhibition levels. Biol Psychiatry 60:597–603 Weber M, Chang W, Breier M, Ko D, Swerdlow NR (2008) Heritable strain differences in sensitivity to the startle gating-disruptive effects of D2 but not D3 receptor stimulation. Behav Pharmacol 19:786–795 Weber M, Chang WL, Park PE, Durbin JP, Luedtke RL, Mach RH, Swerdlow NR (2009). Using prepulse inhibition to detect functional D3 receptor antagonism: effects of WC10 and WC44. Pharmacol Biochem Behav (in press) Zuckerman M, Bone RN, Neary R, Mangelsdorff D, Brustman B (1972) What is the sensation seeker? personality trait and experience correlates of the sensation-seeking scales. J Consult Clin Psychol 39:308–321