1504 46. Lösel R, Wehling M (2003) Nongenomic actions of steroid hormones. Nat Rev Mol Cell Biol 4:46–56 47. Miller WL, Achermann JC, Flück CE (2008) The adrenal cortex and its disorders. In: Sperling MA (ed) Pediatric endocrinology, 3rd edn. Saunders Elsevier, Philadelphia, pp 444–511, 2008 48. Mokra D, Mokry J (2010) Meconium aspiration syndrome. From pathomechanisms to treatment. Nova, New York, p 130 p. ISBN 978-1-60876-944-5 49. Mokra D, Calkovska A, Tonhajzerova I, Petraskova M, Bulikova J, Redfors B, Javorka K (2007) Intratracheal budesonide improved the lung functions in meconium-instilled rabbits without side effects on cardiovascular functions. Eur Respir J 30(Suppl 51):396 p 50. Mokra D, Mokry J, Drgova A, Bulikova J, Petraskova M, Calkovska A (2007) Single-dose vs. two-dose dexamethasone effects on lung inflammation and airway reactivity in meconium-instilled rabbits. J Physiol Pharmacol 58(Suppl 5):379–387 51. Mokra D, Mokry J, Drgova A, Petraskova M, Bulikova J, Calkovska A (2007) Intratracheally administered corticosteroids improved the lung functions in meconium-instilled rabbits. J Physiol Pharmacol 58(Suppl 5):389–398 52. Mokra D, Calkovska A, Tonhajzerova I, Petraskova M, Bulikova J, Redfors B (2008) Dexamethasone treatment improved lung functions in meconium-instilled rabbits, but influenced cardiovas- cular variables. Bratisl Med J 109:95–101 53. Mokra D, Drgova A, Mokry J, Bulikova J, Pullmann R, Durdik P, Petraskova M, Calkovska A (2008) Combination of budesonide and aminophylline diminished acute lung injury in animal model of meconium aspiration syndrome. J Physiol Pharmacol 59(Suppl 6):461–471 54. Mokra D, Tonhajzerova I, Mokry J, Drgova A, Petraskova M, Calkovska A, Javorka K (2008) Rapid cardiovascular effects of dexamethasone in rabbits with meconium-induced acute lung injury. Can J Physiol Pharmacol 86:804–814 55. Mokry J, Mokra D, Antosova M, Bulikova J, Calkovska A, Nosalova G (2006) Dexamethasone alleviates meconium-induced airway hyperresponsiveness and lung inflammation in rabbits. Pediatr Pulmonol 41:55–60 56. Moses D, Holm BA, Spitale P, Liu M, Enhorning G (1991) Inhibition of pulmonary surfactant function by meconium. Am J Obstet Gynecol 164:477–481 57. Newton R (2000) Molecular mechanisms of glucocorticoid action: what is important? Thorax 55:603–613 58. Nimmo AJ, Carstairs JR, Patole SK, Whitehall J, Davidson K, Vink R (2002) Intratracheal administration of glucocorticoids using surfactant as a vehicle. Clin Exp Pharmacol Physiol 29:661–665 59. Pan NY, Hui WS, Tipoe GL, Taylor GW, Leung RY, Lam WK, Tsang KW, Mak JC (2006) Inhibition of pyocyanin-potentiated IL-8 release by steroids in bronchial epithelial cells. Respir Med 100:1614–1622 60. Purdy IB, Wiley DJ (2004) Perinatal corticosteroids: a review of research. Part I: antenatal administration. Neonatal Netw 23:15–30 61. Rizzo MC, Solé D (2006) Inhaled corticosteroids in the treatment of respiratory allergy: safety vs. efficacy. J Pediatr (Rio J) 82: S198–S205 62. Salvia-Roiges MD, Carbonell-Estrany X, Figueras-Aloy J, Rodríguez- Miguélez JM (2004) Efficacy of three treatment schedules in severe meconium aspiration syndrome. Acta Paediatr 93:60–65 63. Schäcke H, Döcke W-D, Asadullah K (2002) Mechanisms involved in the side effects of glucocorticoids. Pharmacol Ther 96:23–43 64. Schmid D, Burmester GR, Tripmacher R, Kuhnke A, Buttgereit F (2000) Bioenergetics of human peripheral blood mononuclear cell metabolism in quiescent, activated, and glucocorticoid-treated states. Biosci Rep 20:289–302 65. Schrama AJ, de Beaufort AJ, Sukul YR, Jansen SM, Poorthuis BJ, Berger HM (2001) Phospholipase A2 is present in meconium and Eur J Pediatr (2011) 170:1495–1505 inhibits the activity of pulmonary surfactant: an in vitro study. Acta Paediatr 90:412–416 66. Soukka H, Halkola L, Aho H, Rautanen M, Kero P, Kääpä P (1997) Methylprednisolone attenuates the pulmonary hyperten- sive response in porcine meconium aspiration. Pediatr Res 42:145–150 67. Soukka H, Jalonen J, Kero P, Kääpä P (1998) Endothelin-1, atrial natriuretic peptide and pathophysiology of pulmonary hypertension in porcine meconium aspiration. Acta Paediatr 87:424–428 68. Soukka H, Viinika L, Kääpä P (1998) Involvement of thromboxane A2 and prostacyclin in the early pulmonary hypertension after porcine meconium aspiration. Pediatr Res 44:838–842 69. Soukka HR, Ahotupa M, Ruutu M, Kääpä P (2002) Meconium stimulates neutrophil oxidative burst. Am J Perinatol 19:279–284 70. Stahn C, Löweneberg M, Hommes DW, Buttgereit F (2007) Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists. Mol Cell Endocrinol 275:71–78 71. Stellato C (2004) Post-transcriptional and nongenomic effects of glucocorticoids. Proc Am Thorac Soc 1:255–263 72. Suchomski SJ, Cummings JJ (2002) A randomized trial of inhaled versus intravenous steroids in ventilator-dependent preterm infants. J Perinatol 22:196–203 73. Sun HW, Miao CY, Liu L, Zhou J, Su DF, Wang YX, Jiang CL (2006) Rapid inhibitory effect of glucocorticoids on airway smooth muscle contractions in guinea pigs. Steroids 71:154–159 74. Thomson/Micromedex (2007) Drug information for the health care professional, vol 1. Greenwood Village, CO, p 898 75. Thung SF, Norwitz ER (2009) Endocrine diseases in pregnancy. In: Strauss JF, Barbieri RL (eds) Yen and Jaffe’s reproductive endocrinology: physiology, pathophysiology and clinical manage- ment, 6th edn. Saunders Elsevier, Philadelphia, pp 615–658, 2009 76. Tølløfsrud PA, Lindenskov PH, Drevon CA, Speer CP, Seidens- pinner S, Saugstad OD (2003) Comparison of pulmonary and inflammatory effects of lipid- and water-soluble components in meconium in newborn piglets. Biol Neonate 84:330–337 77. Tripathi S, Saili A (2007) The effect of steroids on the clinical course and outcome of neonates with meconium aspiration syndrome. J Trop Pediatr 53:8–12 78. Tripathi S, Saili A, Dutta R (2007) Inflammatory markers in meconium induced lung injury in neonates and effect of steroids on their levels: a randomized controlled trial. Indian J Med Microbiol 25:103–107 79. Urbach V, Walsh DE, Mainprice B, Bousquet J, Harvey BJ (2002) Rapid non-genomic inhibition of ATP-induced Cl− secretion by dexamethasone in human bronchial epithelium. J Physiol 545:869–878 80. Vázquez Nava F, Salas Ramírez E, Sánchez Núncio HR, Saldivar González AH, Beltrán Saldaňa J, Cadena Mata D, Pérez Rodríguez P, Pérez Martin J, Almeida VM, Guidos Fogelbach G (2006) Meconium aspiration syndrome, parental atopy and asthma symp- toms in children under two years old. Rev Alerg Méx 53:130–135 81. Verriére VA, Hynes D, Faherty S, Devaney J, Bousquet J, Harvey BJ, Urbach V (2005) Rapid effects of dexamethasone on intracellular pH and Na+/H+ exchanger activity in human bronchial epithelial cells. J Biol Chem 280:35807–35814 82. Vidyasagar D, Zagariya A (2008) Studies of meconium-induced lung injury: inflammatory cytokine expression and apoptosis. J Perinatol 28:S102–S107 83. Wang JY, Yeh TF, Lin YJ, Chen WY, Lin CH (1997) Early postnatal dexamethasone therapy may lessen lung inflammation in premature infants with respiratory distress syndrome on mechan- ical ventilation. Pediatr Pulmonol 23:193–197 84. Wang J, Zhang L, Walther SM (2004) Administration of aerosolized terbutaline and budesonide reduces chlorine gas- induced acute lung injury. J Trauma 56:850–862