5892 Nucleic Acids Research, 2011, Vol. 39, No. 14 group protein Eed to the plasma membrane. Mol. Cell, 13, 179–190. 46. Xie,Y., Chen,C., Stevenson,M.A., Auron,P.E. and Calderwood,S.K. (2002) Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6. J. Biol. Chem., 277, 11802–11810. 47. Ignatenko,N.A. and Gerner,E.W. (2003) Regulation of the HIV1 long terminal repeat by mutant heat shock factor. Exp. Cell Res., 288, 1–8. 48. Inouye,S., Fujimoto,M., Nakamura,T., Takaki,E., Hayashida,N., Hai,T. and Nakai,A. (2007) Heat shock transcription factor 1 opens chromatin structure of interleukin-6 promoter to facilitate binding of an activator or a repressor. J. Biol. Chem., 282, 33210–33217. 49. Di Cesare,S., Poccia,F., Mastino,A. and Colizzi,V. (1992) Surface expressed heat-shock proteins by stressed or human immunodeﬁciency virus (HIV)-infected lymphoid cells represent the target for antibody-dependent cellular cytotoxicity. Immunology, 76, 341–343.