D112 Nucleic Acids Research, 2008, Vol. 36, Database issue A mailing list exists for updates and user assistance (oreganno@bcgsc.ca). The ORegAnno web application is available open-source under the Lesser GNU Public License at https://oreganno.dev.java.net/. ACKNOWLEDGEMENTS We thank the Open Regulatory Annotation Consortium for their continuing eﬀorts to improve this resource through manual curation and record validation. We also thank the owners of regulatory sequence databases that made their data available for inclusion in ORegAnno. This work was funded by British Columbia Cancer Foun- dation; Genome Canada; Genome British Columbia; European Network of Excellence (ENFIN); BioSapiens Network of Excellence; Research Foundation – Flanders (FWO); The Pleiades Promoter Project; Michael Smith Foundation for Health Research to O.L.G., M.C.S., M.G. and S.J.M.J.; Canadian Institutes of Health Research to O.L.G.; European Molecular Biology Laboratory to S.B.M.; Marie Curie Early Stage Research Training Fellowship (MEST-CT-2004-504854) to M.H.; Natural Sciences and Engineering Research Council to S.B.M., and M.G.; Research Foundation – Flanders (FWO) to P.V.L.; Swedish Research Council to C.W. Funding to pay the Open Access publication charges for this article was provided by Genome Canada and Genome British Columbia. Conﬂict of interest statement. None declared. REFERENCES 1. Wasserman,W.W. and Sandelin,A. (2004) Applied bioinformatics for the identiﬁcation of regulatory elements. Nat. Rev. Genet., 5, 276–287. 2. 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