Infectious Diseases in Obstetrics and Gynecology 3 Antibiotic Prophylactic (n = 314) Infection (n = 32) Known GBS result (n = 1, 874) GBS negative (n = 1, 322) No antibiotic (n = 976) Flow diagram Women in the study (n = 2, 108) GBS result unknown (n = 234) Antibiotic (n = 165) No antibiotic (n = 69) GBS positive (n = 552) GBS infants (n = 3) Figure 1 Antibiotic (n = 523) Antibiotic (n = 29) respiratory infection). Among the 314 women who received antibiotics for surgical prophylaxis, 43 (14%) delivered vaginally. Interestingly, these 43 women, although initially GBS negative by culture at 35–37 weeks, met the CDC risk- based criteria for GBS prophylaxis when admitted to labor and delivery. A total of 523 (95%) of the 552 mothers who were GBS positive received intrapartum antibiotic prophylaxis. The three GBS positive infants were born to GBS positive mothers and all three had a gestational age <36 weeks (33.5, 32.5, and 25.2 weeks). The mother who delivered her baby at 33.5 weeks had severe chorioamnionitis with artiﬁcial rupture of membranes and delivered vaginally on the day she was admitted. She received prophylactic ampicillin and subsequently tested positive for GBS. The second mother delivered twins at 32.5 weeks by repeat C- section on the day she was admitted. The mother had premature rupture of membranes with GBS status unknown at time of delivery and subsequently tested positive for GBS. One twin was GBS positive and had intrauterine growth retardation (IUGR). The third GBS positive mother delivered her baby at 25.2 weeks by primary C-section. The mother was admitted eight days prior to delivery and diagnosed with preterm premature rupture of membranes, and chorioam- nionitis. She received ampicillin/sulbactam, Amoxicillin, and Erythromycin antepartum, and Cefazolin at the time the umbilical cord was clamped. The infant, in addition to being GBS positive with bacteremia, subsequently was diagnosed with Klebsiella pneumonia and expired 14 days after delivery. A total of 165 (71%) of the 231 mothers with unknown GBS status received antibiotic prophylaxis for GBS based on weak risk factor assessment. Of these 165 mothers, 106 (64%) delivered babies at <37 weeks gestational age, 1 (0.9%) had rupture of membrane with labor >18 hours, there were no mothers in this group with a temperature >38◦C, and 105 (99%) had no recognized risk factors as outlined in the CDC guidelines [12] except for unknown GBS status. The ﬂow diagram in Figure 1 shows the status of the women in the study. 4. Discussion Our study demonstrates that in a private tertiary care hospital setting, both a high rate of screening for GBS and administration of intrapartum antibiotic prophylaxis can be achieved. No infants ≥37 weeks gestation developed invasive GBS disease. The three infants with early-onset GBS sepsis born to GBS positive mothers were less than 34 weeks gestation, and they would have been treated based on risk factors alone. The results for this study population are reﬂective of the overall population delivering at WHT.