Psychopharmacology (2012) 223:281–297 Region GO GO term Desipramine PCX GO:0015075~ion transmembrane transporter activity GO:0005216~ion channel activity GO:0005624~membrane fraction GO:0016021~integral to membrane GO:0007610~behavior CCX HIP AMY Citalopram PCX CCX HIP GO:0043234~protein complex GO:0022857~transmembrane transporter activity GO:0046983~protein dimerization activity GO:0015075~ion transmembrane transporter activity GO:0042803~protein homodimerization activity GO:0004888~transmembrane receptor activity GO:0004872~receptor activity GO:0016021~integral to membrane GO:0004871~signal transducer activity GO:0051240~positive regulation of multicellular organismal process GO:0007610~behavior GO:0050896~response to stimulus GO:0043234~protein complex GO:0043170~macromolecule metabolic process GO:0031981~nuclear lumen GO:0044260~cellular macromolecule metabolic process GO:0005634~nucleus Fold changes (p value) 3.36 (0.007) 3.36 (0.022) 2.14 (0.026) 1.51 (0.039) 1.64 (0.049) 1.77 (0.002) 2.71 (0.007) 1.86 (0.015) 2.71 (0.020) 2.37 (0.022) 1.85 (0.001) 1.68 (0.002) 1.70 (0.002) 1.52 (0.005) 1.83 (0.029) 1.60 (0.043) 1.24 (0.047) 1.52 (0.002) 1.27 (0.007) 1.62 (0.013) 1.25 (0.021) 1.24 (0.022) TFBS over-representation Binding site TFBS class Pax4 (MA0068) PAIRED-HOMEO MEF2A (MA0052) SRF (MA0083) MADS MADS MEF2A (MA0052) Pax5 (MA0014) SRF (MA0083) ESR1 (MA0112) FOXF2 (MA0030) CEBPA (MA0102) MEF2A (MA0052) CREB1 (MA0018) SRF (MA0083) Pax4 (MA0068) SRF (MA0083) Pax5 (MA0014) CREB1 (MA0018) MEF2A (MA0052) SRF (MA0083) MEF2A (MA0052) Pax4 (MA0068) CREB1 (MA0018) SRF (MA0083) CREB1 (MA0018) Pax5 (MA0014) MEF2A (MA0052) Pax4 (MA0068) SRF (MA0083) CREB1 (MA0018) bZIP MADS PAIRED MADS NUCLEAR RECEPTOR FORKHEAD bZIP MADS bZIP MADS PAIRED-HOMEO MADS PAIRED bZIP MADS MADS MADS PAIRED-HOMEO bZIP MADS bZIP PAIRED MADS PAIRED-HOMEO MADS Table 2 Functional GO classes and TFBSs over-representation in groups of genes associated with time-dependent changes in expression after the DMI (top) and CIT (bottom) treatments 289 Fold change (p value) 10.1 (0.0000) 5.2 (0.0223) 4.9 (0.0317) 5.6 (0.0037) 5.6 (0.004) 5.4 (0.0055) 4.6 (0.0254) 4.3 (0.0357) 4.2 (0.0452) 4.9 (0.0053) 4.9 (0.0055) 4.6 (0.0095) 4.2 (0.0225) 5.4 (0.0028) 4.8 (0.0091) 4.5 (0.0161) 3.9 (0.0484) 7.1 (0.0005) 5.1 (0.0191) 4.9 (0.0232) 4.9 (0.0234) 5.6 (0.0066) 4.9 (0.0223) 4.8 (0.026) 4.7 (0.0289) 4.7 (0.0038) 4.1 (0.0165) 3.8 (0.0317)