300 days, SDLP was significantly increased after both oxaze- pam and lormetazepam in the morning session, but not in the afternoon. In contrast, in the driving simulator, the drugs did not significantly impair performance, and no significant correlation was reported between its parameters and SDLP. This study showed that driving simulator results poorly predicted SDLP. It would be interested to see if SDLP measured in more sophisticated driving simulators is related to on-road assessment of the same parameter. Future studies should also examine other psychometric tests and their relationship to actual driving. The results of our analyses do not mean that psycho- metric tests are useless or can be omitted when evaluating potential adverse effects of CNS drugs. On the contrary, it is of importance that these tests are conducted because they provide supportive and or additional information to that obtained by on-road assessments. Whereas SDLP can be regarded as a measure of overall vehicle control, it does not give information on the specific skills and abilities that led to performance impairment. Information on which skills and abilities are more or less impaired can be obtained by using a suitable psychometric test battery. In addition, psychometric tests enable testing skills and abilities related to risk taking and avoidance that due to safely limitations cannot be conducted in normal traffic. Acknowledgment The studies presented in this article were financially supported by Wyeth-Ayerst Research and UCB Pharma. The authors have no conflicts of interest to disclose. Open Access This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which per- mits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. References Beringer J (1992) ERTS: Experimentelles Run Time System (3.17). Institut für Psychologie, Darmstadt Betts TA, Birtle J (1982) Effects of two hypnotics on actual driving performance next morning. Br Med J 285:852 Bliokas VV, Taylor JE, Leung J, Deane FP (2011) Neuropsychological assessment of fitness to drive following acquired cognitive impairment. Brain Inj 25:471–487 De Raedt R, Pontjaert-Kristoffersen I (2001) Short cognitive/neuro- psychological test battery for first-tier fitness-to-drive assessment of older adults. Clin Neuropsychol 15:329–336 Devos H, Akinwuntan AE, Nieuwboer A, Truijen S, Tant M, De Weerdt W (2011) Screening for fitness to drive after stroke: a systematic review and meta-analysis. Neurology 76:747–756 Duchek JM, Hunt L, Ball K, Buckles V, Morris JC (1998) Attention and driving performance in Alzheimer's disease. J Gerontology 53B:P130–P141 Fitten LJ, Perryman KM, Wilkinson CJ, Little RJ, Burns MM, Pachana N, Mervis JR, Malmgren R, Siembieda DW, Ganzell S (1995) Alzheimer and vascular dementias and driving. JAMA 273:1360–1365 Psychopharmacology (2012) 220:293–301 Fox GK, Bowden SC, Smith DS (1998) On-road assessment of driving competence after brain impairment: review of current practice and recommendations for a standardized examination. Arch Phys Med Rehabil 79:1288–1296 Fuller R (1984) A conceptualization of driving behavior as threat avoidance. Erogonomics 27:1139–1155 Galski T, Ehle HT, Bruno RL (1990) An assessment of measures to predict the outcome of driving evaluations in patients with cerebral damage. Am J Occup Ther 44:708–713 Hindmarch I (1980) Psychomotor function and psychoactive drugs. Br J Clin Pharm 10:189–209 Korteling JE, Kaptein (1996) Neuropsychological driving fitness tests for brain-damaged subjects. Arch Phys Med Rehabil 77:138–146 Marottoli RA, Richardson ED, Stowe MH, Miller EG, Brass LM, Cooney LM (1998) Development of a test battery to identify older drivers at risk for self-reported adverse driving events. JAGS 48:562–568 McKnight AJ, McKnight AS (1999) Multivariate analysis of age- related driver ability and performance deficits. Accid Anal Prev 31:445–454 Michon JA (1985) A critical view of driver behavior models. What do we know, what should we do? In: Evans L, Schwing RC (eds) Human behavior and traffic safety. Plenum Press, New York Moskowitz H, Fiorentino D (2000) A review of the literature on the effects of low doses of alcohol on driving-related skills. National Highway Traffic Safety Administration, Washington, Report DOT HS 809 028 Myers RS, Kalina TD, Roth DL, Goode KT (2000) Relation of useful field of view and other screening tests to on-road driving performance. Percept Mot Ski 91:279–290 Näätänen R, Summala H (1976) Road user behavior and traffic accidents. Elsevier, Amsterdam O'Hanlon JF, Haak TW, Blaauw GJ, Riemersma JBJ (1982) Diazepam impairs lateral position control in highway driving. Science 217:79–81 O’Hanlon JF (1988) Are actual driving tests necessary for evaluating drug safety? Int Clin Psychopharmacol 3(suppl 1):81–85 Orriols L, Salmi L-R, Philip P, Moore N, Delorme B, Castot A, Lagarde E (2009) The impact of medicinal drugs on traffic safety: a systematic review on epidemiological studies. Pharma- coepidemiol Drug Saf 18:647–658 Parrott AC (1991a) Performance tests in human psychopharmacology (1): test reliability and standardization. Hum Psychopharmacol 6:1–9 Parrot AC (1991) Performance tests in human psychopharmacology (2): content validity, criterion validity, and face validity. Hum Psychopharmacol 6:91–98 Parrott AC (1991b) Performance tests in human psychopharmacology (3): construct validity and test interpretation. Hum Psychophar- macol 6:197–207 Ramaekers JG (2003) Antidepressants and driver impairment: empir- ical evidence from a standard on-the-road test. J Clin Psychiatry 64:20–29 Ranney TA (1994) Models of driving behavior: a review of their evolution. Accid Anal Prev 26:733–750 Rasmussen J (1987) The definition of human error and a taxonomy for technical system design. In: Rasmussen J, Duncan K, Leplat J (eds) New technology and human error. Wiley, Chichester Schneider W, Shiffrin RM (1977) Controlled and automatic human information processing: I. Detection search and attention. Psychol Rev 84:1–54 Shiffrin RM, Schneider W (1977) Controlled and automatic human information processing: II. Perceptual learning, automatic attending, and a general theory. Psychol Rev 84:155–171