778 Ettenberg A, Raven MA, Danluck DA, Necessary BD (1999) Evidence for opponent-process actions of intravenous cocaine. Pharmacol Biochem Behav 64:507–512 Foltin RW, Fischman MW (1994) Effects of buprenorphine on the self-administration of cocaine by humans. Behav Pharmacol 5:78–89 Foltin RW, Fischman MW (1996) Effects of methadone or buprenor- phine maintenance on the subjective and reinforcing effects of intravenous cocaine in humans. J Pharmacol Exp Ther 278:1153– 1164 Fuchs RA, Evans KA, Parker MP, See RE (2004) Differential involvement of orbitofrontal cortex subregions in conditioned cue-induced and cocaine-primed reinstatement of cocaine seek- ing in rats. J Neurosci 24:6600–6610 Geist TD, Ettenberg A (1990) A simple method for studying intravenous drug reinforcement in the runway. Pharmacol Biochem Behav 36:703–706 Geist TD, Ettenberg A (1997) Concurrent positive and negative goal box events produce runway behaviors comparable to those of cocaine-reinforced rats. Pharmacol Biochem Behav 57:145–150 Grimm JW, Hope BT, Wise RA, Shaham Y (2001) Neuroadaptation: incubation of cocaine craving after withdrawal. Nature 412:141–142 Guzman D, Ettenberg A (2004) Heroin attenuates the negative consequences of cocaine in a runway model of self- administration. Pharmacol Biochem Behav 79:317–324 Jaffe JH, Cascell NG, Kumor KM, Sherer MA (1989) Cocaine- induced cocaine craving. Psychopharmacology 97:59–64 Kelamangalath L, Wagner JJ (2009) Effects of abstinence or extinction on cocaine seeking as a function of withdrawal. Behav Pharmacol 20:195–203 Kippin TE, Fuchs RA, See RE (2006) Contributions of prolonged contingent and noncontingent cocaine exposure on enhanced reinstatement of cocaine seeking in rats. Psychopharmacology 187:60–70 Knackstedt LA, Ettenberg A (2005) Ethanol consumption reduces the adverse consequences of self-administered intravenous cocaine in rats. Psychopharmacol Berl 178:143–150 Knackstedt LA, Kalivas PW (2007) Extended access to cocaine self- administration enhances drug-primed reinstatement but no be- havioral sensitization. J Pharmacol Exp Ther 322:1103–1109 Knackstedt LA, Samimi MM, Ettenberg A (2002) Evidence for opponent-process actions of intravenous cocaine and cocaethy- lene. Pharmacol Biochem Behav 72:931–936 Kruzich PJ, Grimm JW, Rustay NR, Parks CD, See RE (1999) Predicting relapse to cocaine-seeking behavior: multiple regres- sion approach. Behav Pharmacol 10:513–521 Leri F, Stewart J (2001) Drug-induced reinstatement to heroin and cocaine seeking: a rodent model of relapse in poly-drug use. Exp Clin Psychopharmacol 9:297–306 Lu L, Grimm JW, Shaham Y, Hope BT (2003) Molecular neuro- adaptations in the accumbens and ventral tegmental area during the first 90 days of forced abstinence from cocaine self- administration in rats. J Neurochem 85:1604–1613 Lu L, Grimm JW, Dempsey J, Shaham Y (2004) Cocaine seeking over extended withdrawal periods in rats: different time courses of responding induced by cocaine cues versus cocaine priming over the first 6 months. Psychopharmacology 176:101–108 Lundahl LH, Lukas SE (2007) Negative cocaine affect expectancies are associated with subjective response to cocaine challenge in recreational cocaine users. Addict Behav 32:1262–1271 Mantsch JR, Ho A, Schlussman SD, Kreek MJ (2001) Predictable individual differences in the initiation of cocaine self-administration by rats under extended-access conditions are dose dependent. Psychopharmacology 157:31–39 Psychopharmacology (2011) 214:769–778 Mantsch JR, Yuferov V, Matheiu-Kia AM, Ho A, Kreek MJ (2004) Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats. Psychopharmacology 175:26–36 McFarland K, Ettenberg A (1997) Reinstatement of drug-seeking behavior produced by heroin-predictive environmental stimuli. Psychopharmacology 131:86–92 Mendelson JH, Mello NK (1996) Management of cocaine abuse and dependence. N Engl J Med 334:965–972 Miller NE (1944) Experimental studies of conflict. In: Hunt IMcV (ed) Personality and the behavior disorders. Ronald, New York, pp 431–465 Nelson RA, Boyd SJ, Ziegelstein RC Herning R, Cadet JL, Henningfield JE et al (2005) Effect of rate of administration on subjective and physiological effects of intravenous cocaine in humans. Drug Alcohol Depend 82:19–24 O'Brien CP (1997) A range of research-based pharmacotherapies for addiction. Science 278:66–70 Raven MA, Necessary BD, Danluck DA, Ettenberg A (2000) Comparison of the reinforcing and anxiogenic effects of intravenous cocaine and cocaethylene. Exp Clin Pyschopharma- col 8:117–124 Rohsenow DJ, Niaura RS, Childress AR, Abrams DB, Monti P (1990) Cue-reactivity in addictive behaviors: theoretical and treatment implications. Int J Addict 25:957–993 Shaham Y, Funk D, Erb S, Brown TJ, Walker CD, Stewart J (1997) Corticotropin-releasing factor, but not corticosterone, is involved in stress-induced relapse to heroin-seeking in rats. J Neurosci 17:2605–2614 Shaham Y, Shalev U, Lu L, De Wit H, Stewart J (2003) The reinstatement model of drug relapse: history, methodology and major findings. Psychopharmacol Berl 168:3–20 Shalev U, Morales M, Hope B, Yap J, Shaham Y (2001) Time- dependent changes in extinction behavior and stress-induced reinstatement of drug seeking following withdrawal from heroin in rats. Psychopharmacology 156:98–107 Tran-Nguyen LT, Fuchs RA, Coffey GP, Baker DA, O’Dell LE, Neisewander JL (1998) Time-dependent changes in cocaine- seeking behavior and extracellular dopamine levels in the amygdala during cocaine withdrawal. Neuropsychopharmacol- ogy 19:48–59 Valles R, Rocha A, Nation JR (2006) The effects of acquisition training schedule on extinction and reinstatement of cocaine self- administration in male rats. Exp Clin Psychopharmacol 14:245– 253 Van Dyke C, Byck R (1982) Cocaine. Sci Am 246:128–141 Ward SJ, Morgan D, Roberts DC (2005) Comparison of the reinforcing effects of cocaine and cocaine/heroin combinations under progressive ratio and choice schedules in rats. Neuro- psychopharmacology 30:286–295 Weiss F, Martin-Fardon R, Cioccocioppo R, Kerr TM, Smith DL, Ben-Shahar O (2001) Enduring resistance to extinction of cocaine-seeking behavior induced by drug-related cues. Neuro- psychopharmacology 25:361–372 Winger G, Skjoldager P, Woods JH (1992) Effects of buprenorphine and other opioid agonists and antagonists on alfentanil- and cocaine-reinforced responding rhesus monkeys. J Pharmacol Exp Ther 261:311–317 Withers NW, Pulbirenti L, Koob GF, Gillin JC (1995) Cocaine abuse and dependence. J Clin Psychopharmac 15:63–78 Zhou W, Xhang F, Liu H, Tang S, Lai M, Zhu H, Kalivas PW (2009) Effects of training and withdrawal periods on heroin seeking induced by conditioned cue in an animal model of relapse. Psychopharmacology 203:677–684