Psychopharmacology (2007) 193:85–96 Fig. 5 Effects of WIN55,212-2 on response inhibition as mea- sured in the stop-signal para- digm. Data are depicted as mean (±SEM) percentage of correctly inhibited stop trials with varying SSDs before the mean go reac- tion times (a), go RTs (b) and estimated stop signal reaction times from SSDs 200, 100, and 50 ms (c). *p<0.05 and **p< 0.005 vs vehicle 93 finding further underscores the dissociation between pre- mature and perseverative responding in the 5-CSRTT that has been shown to have a neuroanatomical basis as well (Chudasama et al. 2003). The endocannabinoid system interacts with many other central neurotransmitters systems including the cholinergic, GABAergic, glutamatergic, and opioid systems (Schlicker and Kathmann 2001; Schoffelmeer et al. 2006). Moreover, cannabimimetics have been shown to indirectly modulate the release of dopamine and glutamate in corticostriatal regions (e.g., Cheer et al. 2004; Szabo et al. 1999; Tanda et al. 1997; Xi et al. 2006), most notably in the nucleus accumbens, and particularly, these effects have been linked to the involve- ment of the cannabinoid system in addiction (for review, see De Vries and Schoffelmeer 2005). Although it is beyond the scope of the present study and additional experiments are required to substantiate this, one might speculate that the present findings are explained by these modulatory effects of the cannabinoid system on mesolimbic dopamine release, as inhibitory control processes in the 5-CSRTT have been shown to depend upon dopamine receptor activation within the nucleus accumbens (Cole and Robbins 1987; Pattij et al. 2007). On the other hand, explanations for the beneficial effects of SR141716A on inhibitory control may be due to the role of the endocannabinoid system in feeding behavior (for review, see Di Marzo and Matias 2005). Accordingly, it has been demonstrated that SR141716A reduces intake of normal and palatable food (e.g., Arnone et al. 1997; Freedland et al. 2000; Thornton-Jones et al. 2005) and the motivation to obtain food (Solinas and Goldberg 2005). Nonetheless, despite these reported effects of SR141716A on food intake, anorexic effects of this compound seem unlikely to explain the current data, as both primary indices of food-motivated behavior in the 5-CSRTT, namely, errors of omission and feeder response latencies, were not changed. It is interesting to note that we also observed a moderate beneficial effect of SR141716A on visuospatial attention, as it increased the level of accurate choice at 0.3 mg/kg. Likewise, it has been shown that SR141716A improves social recognition and spatial and aversive memory at