260 Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates, 2nd edn. Academic, New York Petersen A, Wortwein G, Gruber SH, Mathe AA (2008) Escitalopram reduces increased hippocampal cytogenesis in a genetic rat depression model. Neurosci Lett 436:305–308 Phillips RG, LeDoux JE (1992) Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav Neurosci 106:274–285 Plotsky PM, Meaney MJ (1993) Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, me- dian eminence CRF content and stress-induced release in adult rats. Brain Res Mol Brain Res 18:195–200 Pryce CR, Feldon J (2003) Long-term neurobehavioural impact of the postnatal environment in rats: manipulations, effects and medi- ating mechanisms. Neurosci Biobehav Rev 27:57–71 Pu Z, Krugers HJ, Joels M (2007) Corticosterone time-dependently modulates beta-adrenergic effects on long-term potentiation in the hippocampal dentate gyrus. Learn Mem 14:359–367 Pugh CR, Tremblay D, Fleshner M, Rudy JW (1997) A selective role for corticosterone in contextual-fear conditioning. Behav Neurosci 111:503–511 Rao U, Chen LA, Bidesi AS, Shad MU, Thomas MA, Hammen CL (2010) Hippocampal changes associated with early-life adversity and vulnerability to depression. Biol Psychiatry 67:357–364 Rodrigues SM, LeDoux JE, Sapolsky RM (2009) The influence of stress hormones on fear circuitry. Annu Rev Neurosci 32:289– 313 Rosenfeld P, Suchecki D, Levine S (1992) Multifactorial regulation of the hypothalamic–pituitary–adrenal axis during development. Neurosci Biobehav Rev 16:553–568 Sahay A, Hen R (2007) Adult hippocampal neurogenesis in depression. Nat Neurosci 10:1110–1115 Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, Belzung C, Hen R (2003) Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301:805–809 Saxe MD, Battaglia F, Wang JW, Malleret G, David DJ, Monckton JE, Garcia AD, Sofroniew MV, Kandel ER, Santarelli L, Hen R, Drew MR (2006) Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus. Proc Natl Acad Sci U S A 103:17501–17506 Scharfman H (2007) The dentate gyrus, a comprehensive guide to structure, function and clinical implications. Elsevier, Amsterdam Schenk F, Morris RG (1985) Dissociation between components of spatial memory in rats after recovery from the effects of retrohippocampal lesions. Exp Brain Res 58:11–28 Schmidt M, Enthoven L, van Woezik JH, Levine S, de Kloet ER, Oitzl MS (2004) The dynamics of the hypothalamic–pituitary–adrenal axis during maternal deprivation. J Neuroendocrinol 16:52–57 Psychopharmacology (2011) 214:249–260 Sheline YI, Sanghavi M, Mintun MA, Gado MH (1999) Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression. J Neurosci 19:5034–5043 Stanton ME, Gutierrez YR, Levine S (1988) Maternal deprivation potentiates pituitary–adrenal stress responses in infant rats. Behav Neurosci 102:692–700 Stockmeier CA, Mahajan GJ, Konick LC, Overholser JC, Jurjus GJ, Meltzer HY, Uylings HB, Friedman L, Rajkowska G (2004) Cellular changes in the postmortem hippocampus in major depression. Biol Psychiatry 56:640–650 Surget A, Saxe M, Leman S, Ibarguen-Vargas Y, Chalon S, Griebel G, Hen R, Belzung C (2008) Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal. Biol Psychiatry 64:293–301 Ustun TB (2000) Cross-national epidemiology of depression and gender. J Gend Specif Med 3:54–58 Uysal N, Ozdemir D, Dayi A, Yalaz G, Baltaci AK, Bediz CS (2005) Effects of maternal deprivation on melatonin production and cognition in adolescent male and female rats. Neuro Endocrinol Lett 26:555–560 van Praag H, Kempermann G, Gage FH (1999) Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci 2:266–270 Videbech P, Ravnkilde B (2004) Hippocampal volume and depres- sion: a meta-analysis of MRI studies. Am J Psychiatry 161:1957– 1966 Vythilingam M, Heim C, Newport J, Miller AH, Anderson E, Bronen R, Brummer M, Staib L, Vermetten E, Charney DS, Nemeroff CB, Bremner JD (2002) Childhood trauma associated with smaller hippocampal volume in women with major depression. Am J Psychiatry 159:2072–2080 Wisden W, Laurie DJ, Monyer H, Seeburg PH (1992) The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon. J Neurosci 12:1040–1062 Workel JO, Oitzl MS, Fluttert M, Lesscher H, Karssen A, de Kloet ER (2001) Differential and age-dependent effects of maternal deprivation on the hypothalamic–pituitary–adrenal axis of brown Norway rats from youth to senescence. J Neuroendocrinol 13:569–580 Zhang LX, Levine S, Dent G, Zhan Y, Xing G, Okimoto D, Kathleen Gordon M, Post RM, Smith MA (2002) Maternal deprivation increases cell death in the infant rat brain. Brain Res Dev Brain Res 133:1–11 Zhou M, Conboy L, Sandi C, Joels M, Krugers HJ (2009) Fear conditioning enhances spontaneous AMPA receptor-mediated synaptic transmission in mouse hippocampal CA1 area. Eur J Neurosci 30:1559–1564