5582 Nucleic Acids Research, 2005, Vol. 33, No. 17 ACKNOWLEDGEMENTS The authors thank David Haussler, Chuck W Sugnet, Ido Carmel, Rotem Sorek and Amir Goren for sharing datasets, and Rotem Sorek for helpful discussion. This work was sup- ported by a grant from the Israel Science Foundation (1449/04 and 40/05) and, in part, by a grant from the German Israeli Project Cooperation Program, German Israeli R&D, and the Chief Scientist of the Israel Health Ministry to G.A. Funding to pay the Open Access publication charges for this article was provided by German Israeli Research and Development. Conflict of interest statement. None declared. REFERENCES 1. Lareau,L.F., Green,R.E., Bhatnagar,R.S. and Brenner,S.E. (2004) The evolving roles of alternative splicing. Curr. Opin. Struct. Biol., 14, 273–282. 2. Lee,C. and Wang,Q. (2005) Bioinformatics analysis of alternative splicing. Brief Bioinformatics, 6, 23–33. 3. Woodley,L. and Valcarcel,J. (2002) Regulation of alternative pre-mRNA splicing. 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