Candidate genes for SSRI response Yura A, Kiuchi Y, Uchikawa T, et al. 1996. Possible involvement of calmodulin-dependent kinases in Ca2++dependent enhancement of [H3]5-hydroxytryptamine uptake in rat cortex. Brain Res, 738: 96–102. Zanardi R, Benedetti F, Di Bella D, et al. 2000. Efficacy of paroxetine in depression is influenced by a functional polymorphism within the promoter of the serotonin transporter gene. J Clin Psychopharmacol, 20:105–6. Zhang HT, Huang Y, Jin SL, et al. 2002. Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme. Neuropsychopharmacology, 27:587–92. Zhao Y, Zhang H, O’Donnell JM. 2003. Antidepressant-induced increase in high-affinity rolipram binding sites in rat brain: dependence on noradrenergic and serotonergic function. J Pharmacol Exp Therap, 307:246–53. Zill P, Baghai TC, Zwanzger P, et al. 2002. Association analysis of a polymorphism in the G-protein stimulatory alpha subunit in patients with major depression. Am J Med Genet, 114:530–2. Zubenko GS, Hughes HB 3rd, Maher BS, et al. 2002. Genetic linkage of region containing the CREB1 gene to depressive disorders in women from families with recurrent, early-onset, major depression. Am J Med Genet, 114:980–7. Neuropsychiatric Disease and Treatment 2005:1(1) 35