Obstetrics and Gynecology International Table 2: Clinical data for management of retained placenta by treatment group (ITT). Nitroglycerin (n = 55) Placebo (n = 56) P value Relative risk (RR) 95% CI 20 (36.4) n = 51 465 (463) 250 (50; 2200) n = 51 1018 (612) 900 (200; 2500) 24 (43.6) 13 (23.2) n = 54 560 (468) 400 (0; 1800) n = 54 1098 (658) 950 (150; 3000) 26 (46.4) Intention to treat group, ITT: all randomized patients, including 4 patients who did not receive study medication and 2 patients who only received 0.5 mg nitroglycerin. 4 Variable Placental detachment n (%) Blood loss after treatment (mL) Mean (SD) Median (range) Total blood loss (mL) Mean (SD) Median (range) Total blood loss ≥1000 mL n (%) 4 ien 2 lse 0 b a −2 rom −4 fP −6 B ieSn−−180 an−12 g hC−14 −16 0 Nitroglycerin Placebo Mean ± 2 SEM 1.57 (0.87; 2.83) 0.94 (0.62; 1.42) 5 Minutes 15 0.13 0.30 0.52 0.77 (b) 15 5 Minutes (a) 20 e n lse i 15 a b om10 r f R P 5 n i e an g 0 h C −5 0 Nitroglycerin Placebo Mean ± 2 SEM 2 e lien 0 s b a −2 m fro −4 P BD −6 ieg n −8 ahn−10 C−12 15 0 5 Minutes (c) Nitroglycerin Placebo Mean ± 2 SEM Figure 1: Systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse rate (PR) at baseline, 5 and 15 minutes after administration of either nitroglycerin or placebo tablets. All parameters showed diﬀerences of statistical signiﬁcance between the groups (P < 0.05) following administration of the tablets.