Arora M, Weuve J, Schwartz J, Wright RO. 2009. Association of environmental cadmium exposure with periodontal dis- ease in U.S. adults. Environ Health Perspect 117:739–744. Björkman L, Vahter M, Pedersen NL. 2000. Both the environ- ment and genes are important for concentrations of cadmium and lead in blood. Environ Health Perspect 108:719–722. Buchet JP, Lauwerys R, Roels H, Bernard A, Bruaux P, Claeys F, et al. 1990. Renal effects of cadmium body burden of the general population. Lancet 336(8717):699–702. Chen L, Lei L, Jin T, Nordberg M, Nordberg GF. 2006. Plasma metallothionein antibody, urinary cadmium, and renal dys- function in a Chinese type 2 diabetic population. Diabetes Care 29(12):2682–2687. Clark NA, Teschke K, Rideout K, Copes R. 2007. Trace element levels in adults from the west coast of Canada and asso- ciations with age, gender, diet, activities, and levels of other trace elements. Chemosphere 70(1):155–164. Clemens S. 2006. Toxic metal accumulation, responses to expo- sure and mechanisms of tolerance in plants. Biochimie 88(11):1707–1719. Copes R, Clark NA, Rideout K, Palaty J, Teschke K. 2008. Uptake of cadmium from Pacific oysters (Crassostrea gigas) in British Columbia oyster growers. Environ Res 107(2):160–169. Edwards JR, Prozialeck WC. 2009. Cadmium, diabetes and chronic kidney disease. Toxicol Appl Pharmacol 238(3):289–293. Erie JC, Butz JA, Good JA, Erie EA, Burritt MF, Cameron JD. 2005. Heavy metal concentrations in human eyes. Am J Ophthalmol 139(5):888–893. Erie JC, Good JA, Butz JA, Hodge DO, Pulido JS. 2007. Urinary cadmium and age-related macular degeneration. Am J Ophthalmol 144(3):414–418. Eum KD, Lee MS, Paek D. 2008. Cadmium in blood and hyper- tension. Sci Total Environ 407(1):147–153. European Food Safety Authority (EFSA). 2009. Cadmium in food–Scientific Opinion of the Panel on Contaminants in the Food Chain. Available: http://www.efsa.europa. eu/EFSA/efsa_locale-1178620753812_1211902396126.htm [accessed 29 December 2009]. Everett CJ, Frithsen IL. 2008. Association of urinary cadmium and myocardial infarction. Environ Res 106(2):284–286. Finley JW. 1999. Manganese absorption and retention by young women is associated with serum ferritin concentration. Am J Clin Nutr 70(1):37–43. Francesconi KA. 2007. Toxic metal species and food regula- tions—making a healthy choice. Analyst 132(1):17–20. Franz E, Römkens P, van Raamsdonk L, van der Fels-Klerx I. 2008. A chain modeling approach to estimate the impact of soil cadmium pollution on human dietary exposure. J Food Prot 71(12):2504–2513. Gallagher CM, Kovach JS, Meliker JR. 2008. Urinary cad- mium and osteoporosis in U.S. Women ≥ 50 years of age: NHANES 1988–1994 and 1999–2004. Environ Health Perspect 116:1338–1343. Gundacker C, Pietschnig B, Wittmann KJ, Salzer H, Stöger H, Reimann-Dorninger G, et al. 2007. Smoking, cereal con- sumption, and supplementation affect cadmium content in breast milk. J Expo Sci Environ Epidemiol 17(1):39–46. Haswell-Elkins M, Imray P, Satarug S, Moore MR, O’dea K. 2007a. Urinary excretion of cadmium among Torres Strait Islanders (Australia) at risk of elevated dietary exposure through traditional foods. J Expo Sci Environ Epidemiol 17(4):372–377. Haswell-Elkins M, McGrath V, Moore M, Satarug S, Walmby M, Ng J. 2007b. Exploring potential dietary contributions including traditional seafood and other determinants of urinary cadmium levels among indigenous women of a Torres Strait Island (Australia). J Expo Sci Environ Epidemiol 17(3):298–306. Haswell-Elkins M, Satarug S, O’Rourke P, Moore M, Ng J, McGrath V, et al. 2008. Striking association between uri- nary cadmium level and albuminuria among Torres Strait Islander people with diabetes. Environ Res 106(3):379–383. Horiguchi H, Oguma E, Sasaki S, Miyamoto K, Ikeda Y, Machida M, et al. 2004. Comprehensive study of the effects of age, iron deficiency, diabetes mellitus, and cadmium burden on dietary cadmium absorption in cadmium- exposed female Japanese farmers. Toxicol Appl Pharmacol 196(1):114–123. IARC (International Agency for Research on Cancer). 1993. Beryllium, Cadmium, Mercury and Exposures in the Glass Manufacturing Industry. IARC Monogr Eval Carcinog Risk Chem Hum 58:1–444. Available: http://monographs.iarc.fr/ ENG/Monographs/vol58/index.php [accessed 29 December 2009]. Inaba T, Kobayashi E, Suwazono Y, Uetani M, Oishi M, Nakagawa H, et al. 2005. Estimation of cumulative cadmium intake causing Itai-itai disease. Toxicol Lett 159(2):192–201. IPCS (International Programme on Chemical Safety). 1992. Cadmium–Environmental Health Criteria 134. Geneva:World Health Organization. Available: http://www.inchem.org/ documents/ehc/ehc/ehc134.htm [accessed 29 December 2009]. Järup L, Åkesson A. 2009. Current status of cadmium as an environmental health problem. Toxicol Appl Pharmacol 238(3):201–208. Kellen E, Zeegers MP, Hond ED, Buntinx F. 2007. Blood cad- mium may be associated with bladder carcinogenesis: the Belgian case-control study on bladder cancer. Cancer Detect Prev 31(1):77–82. Kikuchi Y, Nomiyama T, Kumagai N, Dekio F, Uemura T, Takebayashi T, et al. 2003. Uptake of cadmium in meals from the digestive tract of young non-smoking Japanese female volunteers. J Occup Health 45(1):43–52. Kippler M, Ekström EC, Lönnerdal B, Goessler W, Åkesson A, El Arifeen S, et al. 2007. Influence of iron and zinc status on cadmium accumulation in Bangladeshi women. Toxicol Appl Pharmacol 222(2):221–226. Kippler M, Goessler W, Nermell B, Ekström EC, Lönnerdal B, El Arifeen S, et al. 2009. Factors influencing intestinal cad- mium uptake in pregnant Bangladeshi women–a prospec- tive cohort study. Environ Res 109(7):914–921. Kippler M, Lönnerdal B, Goessler W, Ekström EC, Arifeen SE, Vahter M. 2008. Cadmium interacts with the transport of essential micronutrients in the mammary gland–a study in rural Bangladeshi women. Toxicology 257(1-2):64–69. Kobayashi E, Okubo Y, Suwazono Y, Kido T, Nogawa K. 2002. Dose-response relationship between total cadmium intake calculated from the cadmium concentration in rice col- lected from each household of farmers and renal dysfunc- tion in inhabitants of the Jinzu River basin, Japan. J Appl Toxicol 22(6):431–436. Kobayashi E, Suwazono Y, Uetani M, Inaba T, Oishi M, Kido T, et al. 2006. Estimation of benchmark dose for renal dys- function in a cadmium non-polluted area in Japan. J Appl Toxicol 26(4):351–355. Kriegel AM, Soliman AS, Zhang Q, El-Ghawalby N, Ezzat F, Soultan A, et al. 2006. Serum cadmium levels in pancreatic cancer patients from the East Nile Delta region of Egypt. Environ Health Perspect 114:113–119. Lampe BJ, Park SK, Robins T, Mukherjee B, Litonjua AA, Amarasiriwardena C, et al. 2008. Association between 24-hour urinary cadmium and pulmonary function among community-exposed men: the VA Normative Aging Study. Environ Health Perspect 116:1226–1230. Lyon TD, Aughey E, Scott R, Fell GS. 1999. Cadmium concen- trations in human kidney in the UK: 1978–1993. J Environ Monit 1(3):227–231. McElroy JA, Shafer MM, Hampton JM, Newcomb PA. 2007. Predictors of urinary cadmium levels in adult females. Sci Total Environ 382(2-3):214–223. McElroy JA, Shafer MM, Trentham-Dietz A, Hampton JM, Newcomb PA. 2006. Cadmium exposure and breast cancer risk. J Natl Cancer Inst 98(12):869–873. McKenzie J, Kjellstrom T, Sharma R. 1986. Project Summary. Cadmium Intake via Oysters and Health Effects in New Zealand [microform]: Cadmium Intake, Metabolism, and Effects in People with a High Intake of Ooysters in New Zealand. EPA/600/S1-86/004. Research Triangle Park, NC:US Environmental Protection Agency. McLaughlin MJ, Whatmuff M, Warne M, Heemsbergen D, Barry G, Bell M, et al. 2006. A field investigation of solu- bility and food chain accumulation of biosolid-cadmium across diverse soil types. Environ Chem 3(6):428–432; doi:10.1071/EN06061 [Online 13 December 2006]. Menke A, Muntner P, Silbergeld EK, Platz EA, Guallar E. 2009. Cadmium levels in urine and mortality among U.S. adults. Environ Health Perspect 117:190–196. Nakagawa H, Nishijo M, Morikawa Y, Miura K, Tawara K, Kuriwaki J, et al. 2006. Urinary cadmium and mortality among inhabitants of a cadmium-polluted area in Japan. Environ Res 100(3):323–329. Navas-Acien A, Selvin E, Sharrett AR, Calderon-Aranda E, Silbergeld E, Guallar E. 2004. Lead, cadmium, smoking, and increased risk of peripheral arterial disease. Circulation 109(25):3196–3201. Environmental Health Perspectives • volume 118 | number 2 | February 2010 Cadmium in food and human health Navas-Acien A, Silbergeld EK, Sharrett R, Calderon-Aranda E, Selvin E, Guallar E. 2005. Metals in urine and peripheral arterial disease. Environ Health Perspect 113:164–169. Navas-Acien A, Tellez-Plaza M, Guallar E, Muntner P, Silbergeld E, Jaar B, et al. 2009. Blood cadmium and lead and chronic kidney disease in US adults: a joint analysis. Am J Epidemiol 170(9):1154–1164; doi:10.1093/aje/kwp248 [Online 21 August 2009]. Nawrot T, Plusquin M, Hogervorst J, Roels HA, Celis H, Thijs L, et al. 2006. Environmental exposure to cadmium and risk of cancer: a prospective population-based study. Lancet Oncol 7(2):119–126. Nawrot TS, Van Hecke E, Thijs L, Richart T, Kuznetsova T, Jin Y, et al. 2008. Cadmium-related mortality and long-term secular trends in the cadmium body burden of an envi- ronmentally exposed population. Environ Health Perspect 116:1620–1628. Nishijo M, Morikawa Y, Nakagawa H, Tawara K, Miura K, Kido T, et al. 2006. Causes of death and renal tubular dys- function in residents exposed to cadmium in the environ- ment. Occup Environ Med 63(8):545–550. Prankel SH, Nixon RM, Phillips CJ. 2005. Implications for the human food chain of models of cadmium accumulation in sheep. Environ Res 97(3):348–358. Reeves PG, Vanderpool RA. 1997. Cadmium burden of men and women who report regular consumption of confectionery sunflower kernels containing a natural abundance of cad- mium. Environ Health Perspect 105:1098–1104. Satarug S, Baker JR, Reilly PE, Moore MR, Williams DJ. 2002. Cadmium levels in the lung, liver, kidney cortex, and urine samples from Australians without occupational exposure to metals. Arch Environ Health 57(1):69–77. Satarug S, Baker JR, Urbenjapol S, Haswell-Elkins M, Reilly PE, Williams DJ, et al. 2003. A global perspective on cadmium pollution and toxicity in non-occupationally exposed popu- lation. Toxicol Lett 137(1-2):65–83. Satarug S, Haswell-Elkins MR, Moore MR. 2000. Safe levels of cadmium intake to prevent renal toxicity in human sub- jects. Br J Nutr 84(6):791–802. Satarug S, Moore MR. 2004. Adverse health effects of chronic exposure to low-level cadmium in foodstuffs and cigarette smoke. Environ Health Perspect 112:1099–1103. Satarug S, Nishijo M, Ujjin P, Vanavanitkun Y, Moore MR. 2005. Cadmium-induced nephropathy in the development of high blood pressure. Toxicol Lett 157(1):57–68. Satarug S, Ujjin P, Vanavanitkun Y, Baker JR, Moore MR. 2004. Influence of body iron store status and cigarette smoking on cadmium body burden of healthy Thai women and men. Toxicol Lett 148(3):177–185. Schutte R, Nawrot T, Richart T, Thijs L, Roels HA, Van Bortel LM. 2008a. Arterial structure and function and envi- ronmental exposure to cadmium. Occup Environ Med 65(6):412–419. Schutte R, Nawrot TS, Richart T, Thijs L, Vanderschueren D, Kuznetsova T, et al. 2008b. Bone resorption and envi- ronmental exposure to cadmium in women: a population study. Environ Health Perspect 116 :777–783. Schwartz GG, Il’yasova D, Ivanova A. 2003. Urinary cadmium, impaired fasting glucose, and diabetes in the NHANES III. Diabetes Care 26(2):468–470. Slikker W Jr, Andersen ME, Bogdanffy MS, Bus JS, Cohen SD, Conolly RB, et al. 2004. Dose-dependent transitions in mechanisms of toxicity: case studies. Toxicol Appl Pharmacol 201(3):226–294. Suwazono Y, Sand S, Vahter M, Filipsson AF, Skerfving S, Lidfeldt J, et al. 2006. Benchmark dose for cadmium-in- duced renal effects in humans. Environ Health Perspect 114:1072–1076. T e e y a k a s e m W , N i s h i j o M , H o n d a R , S a t a r u g S , Swaddiwudhipong W, Ruangyuttikarn W. 2007. Monitoring of cadmium toxicity in a Thai population with high-level environmental exposure. Toxicol Lett 169(3):185–195. Tellez-Plaza M, Navas-Acien A, Crainiceanu CM, Guallar E. 2008. Cadmium exposure and hypertension in the 1999– 2004 National Health and Nutrition Examination Survey (NHANES). Environ Health Perspect 116:51–56. Thomas LD, Hodgson S, Nieuwenhuijsen M, Jarup L. 2009. Early kidney damage in a population exposed to cadmium and other heavy metals. Environ Health Perspect 117:181–184. Uetani M, Kobayashi E, Suwazono Y, Honda R, Nishijo M, Nakagawa H, et al. 2006. Tissue cadmium (Cd) concen- trations of people living in a Cd polluted area, Japan. Biometals 19(5):521–525. 189