4. Moldovan,G.L. and D’Andrea,A.D. (2009) How the Fanconi Anemia Pathway Guards the Genome. Annu. Rev. Genet., 43, 223–249. 5. Wang,W. (2007) Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins. Nat. Rev. Genet., 8, 735–748. 6. Kim,J.M., Kee,Y., Gurtan,A. and D’Andrea,A.D. (2008) Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24. Blood, 111, 5215–5222. 7. Xue,Y., Li,Y., Guo,R., Ling,C. and Wang,W. (2008) FANCM of the Fanconi anemia core complex is required for both monoubiquitination and DNA repair. Hum. Mol. Genet., 17, 1641–1652. 8. Collis,S.J., Ciccia,A., Deans,A.J., Horejsi,Z., Martin,J.S., Maslen,S.L., Skehel,J.M., Elledge,S.J., West,S.C. and Boulton,S.J. (2008) FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. Mol. Cell, 32, 313–324. 9. Huang,M., Kim,J.M., Shiotani,B., Yang,K., Zou,L. and D’Andrea,A.D. (2010) The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response. Mol. Cell, 39, 259–268. 10. Schwab,R.A., Blackford,A.N. and Niedzwiedz,W. (2010) ATR activation and replication fork restart are defective in FANCM-deﬁcient cells. EMBO J., 29, 806–818. 11. Bakker,S.T., van de Vrugt,H.J., Rooimans,M.A., Oostra,A.B., Steltenpool,J., Delzenne-Goette,E., van der Wal,A., van der Valk,M., Joenje,H., te Riele,H. et al. (2009) FancM-deﬁcient mice reveal unique features of Fanconi anemia complementation group M. Hum. Mol. Genet., 18, 3484–3495. 12. Rosado,I.V., Niedzwiedz,W., Alpi,A.F. and Patel,K.J. (2009) The Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensable for DNA crosslink repair. Nucleic Acids Res., 37, 4360–4370. 13. Deans,A.J. and West,S.C. (2009) FANCM connects the genome instability disorders Bloom’s Syndrome and Fanconi Anemia. Mol. Cell, 36, 943–953. 14. Prakash,R., Satory,D., Dray,E., Papusha,A., Scheller,J., Kramer,W., Krejci,L., Klein,H., Haber,J.E., Sung,P. et al. (2009) Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination. Genes Dev., 23, 67–79. 15. Sun,W., Nandi,S., Osman,F., Ahn,J.S., Jakovleska,J., Lorenz,A. and Whitby,M.C. (2008) The ﬁssion yeast FANCM ortholog Fml1 promotes recombination at stalled replication forks and limits crossing over during double-strand break repair. Mol. Cell, 32, 118–128. 16. Gari,K., Decaillet,C., Delannoy,M., Wu,L. and Constantinou,A. (2008) Remodeling of DNA replication structures by the branch point translocase FANCM. Proc. Natl Acad. Sci. USA, 105, 16107–16112. 17. Gari,K., Decaillet,C., Stasiak,A.Z., Stasiak,A. and Constantinou,A. (2008) The Fanconi anemia protein FANCM can promote branch migration of Holliday junctions and replication forks. Mol. Cell, 29, 141–148. 18. Zheng,X.F., Prakash,R., Saro,D., Longerich,S., Niu,H. and Sung,P. (2011) Processing of DNA structures via DNA unwinding and branch migration by the S. cerevisiae Mph1 protein. DNA Repair, 10, 1034–1043. 19. Svendsen,J.M. and Harper,J.W. (2010) GEN1/Yen1 and the SLX4 complex: Solutions to the problem of Holliday junction resolution. Genes Dev., 24, 521–536. 20. Yan,Z., Delannoy,M., Ling,C., Daee,D., Osman,F., Muniandy,P.A., Shen,X., Oostra,A.B., Du,H., Steltenpool,J. et al. Nucleic Acids Research, 2012, Vol. 40, No. 19 9595 (2010) A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. Mol. Cell, 37, 865–878. 21. Singh,T.R., Bakker,S.T., Agarwal,S., Jansen,M., Grassman,E., Godthelp,B.C., Ali,A.M., Du,C.H., Rooimans,M.A., Fan,Q. et al. (2009) Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M. Blood, 114, 174–180. 22. Goldstein,A.L. and McCusker,J.H. (1999) Three new dominant drug resistance cassettes for gene disruption in Saccharomyces cerevisiae. Yeast, 15, 1541–1553. 23. Bahler,J., Wu,J.Q., Longtine,M.S., Shah,N.G., McKenzie,A. 3rd, Steever,A.B., Wach,A., Philippsen,P. and Pringle,J.R. (1998) Heterologous modules for efﬁcient and versatile PCR-based gene targeting in Schizosaccharomyces pombe. Yeast, 14, 943–951. 24. Maundrell,K. (1993) Thiamine-repressible expression vectors pREP and pRIP for ﬁssion yeast. Gene, 123, 127–130. 25. Moreno,S., Klar,A. and Nurse,P. (1991) Molecular genetic analysis of ﬁssion yeast Schizosaccharomyces pombe. Methods Enzymol., 194, 795–823. 26. Ahn,J.S., Osman,F. and Whitby,M.C. (2005) Replication fork blockage by RTS1 at an ectopic site promotes recombination in ﬁssion yeast. EMBO J., 24, 2011–2023. 27. Osman,F. and Whitby,M.C. (2009) Monitoring homologous recombination following replication fork perturbation in the ﬁssion yeast Schizosaccharomyces pombe. Methods Mol. Biol., 521, 535–552. 28. Baykov,A.A., Evtushenko,O.A. and Avaeva,S.M. (1988) A malachite green procedure for orthophosphate determination and its use in alkaline phosphatase-based enzyme immunoassay. Anal. Biochem., 171, 266–270. 29. Whitby,M.C. and Dixon,J. (1997) A new Holliday junction resolving enzyme from Schizosaccharomyces pombe that is homologous to CCE1 from Saccharomyces cerevisiae. J. Mol. Biol., 272, 509–522. 30. Whitby,M.C. and Dixon,J. (1998) Substrate speciﬁcity of the SpCCE1 holliday junction resolvase of Schizosaccharomyces pombe. J. Biol. Chem., 273, 35063–35073. 31. Whitby,M.C., Osman,F. and Dixon,J. (2003) Cleavage of model replication forks by ﬁssion yeast Mus81-Eme1 and budding yeast Mus81-Mms4. J. Biol. Chem., 278, 6928–6935. 32. Blastyak,A., Pinter,L., Unk,I., Prakash,L., Prakash,S. and Haracska,L. (2007) Yeast Rad5 protein required for postreplication repair has a DNA helicase activity speciﬁc for replication fork regression. Mol. Cell, 28, 167–175. 33. Ralf,C., Hickson,I.D. and Wu,L. (2006) The Bloom’s syndrome helicase can promote the regression of a model replication fork. J. Biol. Chem., 281, 22839–22846. 34. West,S.C. (1995) Holliday junctions cleaved by Rad1? Nature, 373, 27–28. 35. Larson,K., Sahm,J., Shenkar,R. and Strauss,B. (1985) Methylation-induced blocks to in vitro DNA replication. Mutat. Res., 150, 77–84. 36. Schurer,K.A., Rudolph,C., Ulrich,H.D. and Kramer,W. (2004) Yeast MPH1 gene functions in an error-free DNA damage bypass pathway that requires genes from Homologous recombination, but not from postreplicative repair. Genetics, 166, 1673–1686. 37. Wu,L. and Hickson,I.D. (2003) The Bloom’s syndrome helicase suppresses crossing over during homologous recombination. Nature, 426, 870–874. 38. Osman,F., Dixon,J., Doe,C.L. and Whitby,M.C. (2003) Generating crossovers by resolution of nicked Holliday junctions: a role for Mus81-Eme1 in meiosis. Mol. Cell, 12, 761–774.