W450 Nucleic Acids Research, 2007, Vol. 35, Web Server issue SUPPLEMENTARY DATA Supplementary Data are available at NAR Online. ACKNOWLEDGEMENTS We want to thank Stefan Wiemann, Alex Mehrle and Ingo Schupp for fruitful discussions and suggestions during the developmental phase and for intense testing in the relase phase. Bernhard Heinzel for his help in programming 2DSweep, Ulrich Pﬁsterer, Katharina Willmann, Zsuzsanna Varga and Jennifer Honek for benchmarks and testing during the entire process. The program of ‘Retorno de Investigadores de la Junta de Andalucia’ ﬁnanced Dr C. del Val. Funding to pay the Open Access publication charges for this article was provided by Dep. Molecular Biophysics, Deutsches Krebsforschungszentrum. Conﬂict of interest statement. None declared. REFERENCES 1. Wiemann,S., Weil,B., Wellenreuther,R., Gassenhuber,J., Glassl,S., Ansorge,W., Bocher,M., Blocker,H., Bauersachs,S. et al. 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