Pharmacotherapy options in epileptic patients with mood disorders include carbamazepine and valproate, considered drugs of ﬁrst choice for their normothymic mode of action (Kalinin et al 2005). Giving patients AEDs which can cause depression, such as topiramate or levotiracetan must be avoided. Topiramate, in particular, has been associated with suicide among epileptic patients (Rejis et al 2004; Prueter et al 2005; Selai et al 2005). As well as AED therapy, the antidepressant selective sero- tonin reuptake inhibitors (SSRIs) can be used to control the affective aspects. However children and adolescents should not be given SSRIs as ﬁrst-line agents for mild to moderate depression and should be treated with nonsomatic therapies, especially cognitive-behavioral therapy, interpersonal psy- chotherapy, group therapy, and psychoeducational programs (Baker et al 2006). 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