4 Obstetrics and Gynecology International Table 1: Risk of neonatal morbidity a according to preterm birth and maternal use of CNS-active drugs b after the ﬁrst trimester (both 2nd and 3rd trimester). Among all infants, 6.0% were born preterm, and among infants of women using CNS-active drugs, 8.2% were born preterm. Infant group With neonatal pathology Total number % OR 95% CI All infants 22015 315975 7.0 1.00 Reference Preterm births 7465 18836 39.6 12.3 12.0–12.7 CNS-active drugs, all infants 541 4425 12.2 1.83 1.67–2.00 CNS-active drugs, term infants 380 4009 9.5 2.05 1.84–2.28 aInfant morbidity consists of one or more of the following conditions: respiratory disorders (ICD-10 codes P22–P28), hypoglycaemia (P70.4–P70.9), neonatal convulsions (P90), other disturbances of cerebral status (P91), low Apgar score (Apgar 5 minutes <7). bThe drugs studies include opioids, anticonvulsants, antipsychotics, sedative/hypnotics, and antidepressants. Table 2: Impact of various maternal variables on the risk for any relatively severe congenital malformation in the infants and on the use of antidepressant drugs. Relatively severe malformation a Maternal use of antidepressants Variable OR 95% CI OR 95% CI Maternal age <20 1.07 0.99–1.15 0.69 0.60–0.79 20–24 1.04 1.00–1.07 0.91 0.86–0.97 25–29 1.00 Reference 1.00 Reference 30–34 1.00 0.97–1.02 1.19 1.14–1.24 35–39 1.02 0.99–1.06 1.52 1.99–1.60 40–44 1.15 1.08–1.23 1.78 1.62–1.96 ≥45 1.02 0.74–1.41 2.36 1.60–3.49 Parity 1 1.00 Reference 1.00 Reference 2 0.89 0.87–0.91 0.67 0.64–0.70 3 0.90 0.87–0.93 0.85 0.80–0.89 ≥4 0.89 0.85–0.93 0.84 0.78–0.90 Smoking None 1.00 Reference 1.00 Reference <10 cigs/day 1.06 1.03–1.11 2.39 2.27–2.51 ≥10 cigs/day 1.09 1.03–1.15 3.84 3.63–4.07 Body mass index <19.8 1.00 0.96–1.04 1.03 0.96–1.20 19.8–25.9 1.00 Reference 1.00 Reference 26–29.9 1.09 1.06–1.11 1.22 1.17–1.27 30–39.9 1.15 1.11–1.20 1.49 1.41–1.57 ≥40 1.39 1.23–1.56 2.19 1.92–2.50 Number of years of unwanted childlessness 0 1.00 Reference 1.00 Reference 1 1.02 0.95–1.09 0.89 0.88–0.99 2 1.08 1.01–1.15 0.90 0.81–1.01 3 1.12 1.02–1.29 0.66 0.56–0.78 4 1.30 1.17–1.45 0.80 0.65–0.98 ≥5 1.30 1.25–1.41 0.82 0.71–0.95 Number of previous miscarriages 0 1.00 Reference 1.00 Reference 1 1.05 1.02–1.05 0.99 0.95–1.04 2 1.05 0.98–1.11 1.08 0.99–1.17 ≥3 1.12 1.02–1.32 1.15 1.01–1.30 aAny congenital malformation with the exception of the following conditions which are common and variably registered: preauricular tag, patent ductus at preterm birth, undescended testicle, hip (sub)luxation, tongue tie, single umbilical artery, nevus.