Nucleic Acids Research, 2011, Vol. 39, Database issue D693 Figure 1. The Reactome pathway browser and the molecular overlays. (A) The main features of the pathway browser are the ‘Search’ bar at the top, the ‘Pathways’ panel on the left, the ‘Visualization’ panel on the right and a ‘Details’ panel (hidden by default when the pathway browser ﬁrst loads). When a pathway is selected from the ‘Pathways’ panel hierarchy, it is highlighted in bright green in the hierarchy and its parent terms are highlighted in yellow–green. A description of any reaction or pathway in the pathway diagrams can be displayed below the diagram in the ‘Details’ panel by selecting the event within the diagram. Right-clicking the mouse while the cursor is over a physical entity displays the context sensitive menus. (B) Selecting ‘Other Pathways’ displays additional Reactome pathways that contain the highlighted physical entity. Navigating to the additional pathway is achieved by clicking the pathway name. (C) Selecting ‘Participating Molecules’ displays additional components of the macromolecular complex. Displaying the component information in the ‘Details’ panel is achieved by clicking the entity name. (D) Protein–protein interactions are displayed in the pathway browser for SHC1 [cytosol] and SHP2 [cytosol] physical entities.