1402 Freitag M, Lee DW, Kothe GO, Pratt RJ, Aramayo R, Selker EU (2004) DNA methylation is independent of RNA interference in Neurospora. Science 304:1939 Galagan JE, Calvo SE, Cuomo C, Ma LJ, Wortman JR, Batzoglou S, Lee SI, Basturkmen M, Spevak CC, Clutterbuck J, Kapitonov V, Jurka J, Scazzocchio C, Farman M, Butler J, Purcell S, Harris S, Braus GH, Draht O, Busch S, D'Enfert C, Bouchier C, Goldman GH, Bell-Pedersen D, Griffiths-Jones S, Doonan JH, Yu J, Vienken K, Pain A, Freitag M, Selker EU, Archer DB, Penalva MA, Oakley BR, Momany M, Tanaka T, Kumagai T, Asai K, Machida M, Nierman WC, Denning DW, Caddick M, Hynes M, Paoletti M, Fischer R, Miller B, Dyer P, Sachs MS, Osmani SA, Birren BW (2005) Sequencing of Aspergillus nidulans and com- parative analysis with A. fumigatus and A. oryzae. Nature 438:1105–1115 Galarneau L, Nourani A, Boudreault AA, Zhang Y, Heliot L, Allard S, Savard J, Lane WS, Stillman DJ, Cote J (2000) Multiple links between the NuA4 histone acetyltransferase complex and epige- netic control of transcription. Mol Cell 5:927–937 Gardiner SA, Boddu J, Berthiller F, Hametner C, Stupar RM, Adam G, Muehlbauer GJ (2010) Transcriptome analysis of the barley– deoxynivalenol interaction: evidence for a role of glutathione in deoxynivalenol detoxification. Mol Plant Microbe Interact 23:962–976 Gardner KE, Allis CD, Strahl BD (2011) Operating on chromatin, a colorful language where context matters. J Mol Biol 409:36–46 Georgianna DR, Payne GA (2009) Genetic regulation of aflatoxin bio- synthesis: from gene to genome. Fungal Genet Biol 46:113–125 Gourama HB, Lloyd B (1995) Aspergillus flavus and Aspergillus para- siticus: aflatoxigenic fungi of concern in foods and feeds. J Food Prot 58:1395–1404, 1310 Grant PA, Duggan L, Cote J, Roberts SM, Brownell JE, Candau R, Ohba R, Owen-Hughes T, Allis CD, Winston F, Berger SL, Workman JL (1997) Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex. Genes Dev 11:1640–1650 Grant PA, Schieltz D, Pray-Grant MG, Yates JR 3rd, Workman JL (1998) The ATM-related cofactor Tra1 is a component of the purified SAGA complex. Mol Cell 2:863–867 Grewal SI, Jia S (2007) Heterochromatin revisited. Nat Rev Genet 8:35–46 Grimaldi B, Coiro P, Filetici P, Berge E, Dobosy JR, Freitag M, Selker EU, Ballario P (2006) The Neurospora crassa White Collar-1 dependent blue light response requires acetylation of histone H3 lysine 14 by NGF-1. Mol Biol Cell 17:4576–4583 Ha Huy K, Luckner M (1979) Structure and function of the conidio- spore pigments of Penicillium cyclopium. Z Allg Mikrobiol 19:117–122 Haas H (2003) Molecular genetics of fungal siderophore biosynthesis and uptake: the role of siderophores in iron uptake and storage. Appl Microbiol Biotechnol 62:316–330 He H, Lehming N (2003) Global effects of histone modifications. Brief Funct Genomic Proteomic 2:234–243 Heitz E (1928) Das heterochromatin der moose. I Jahrb Wiss Botanik 69:762–818 Hickman MA, Froyd CA, Rusche LN (2011) Reinventing heterochro- matin in budding yeasts: Sir2 and the origin recognition complex take center stage. Eukaryot Cell 10:1183–1192 Hoffmeister D, Keller NP (2007) Natural products of filamentous fungi: enzymes, genes, and their regulation. Nat Prod Rep 24:393–416 Hohn TM, Desjardins AE, McCormick SP (1995) The Tri4 gene of Fusarium sporotrichioides encodes a cytochrome P450 monoox- ygenase involved in trichothecene biosynthesis. Mol Gen Genet 248:95–102 Appl Microbiol Biotechnol (2012) 95:1389–1404 Honda S, Selker EU (2008) Direct interaction between DNA methyl- transferase DIM-2 and HP1 is required for DNA methylation in Neurospora crassa. Mol Cell Biol 28:6044–6055 Honda S, Lewis ZA, Huarte M, Cho LY, David LL, Shi Y, Selker EU (2010) The DMM complex prevents spreading of DNA methyl- ation from transposons to nearby genes in Neurospora crassa. Genes Dev 24:443–454 Honda S, Lewis ZA, Shimada K, Fischle W, Sack R, Selker EU (2012) Heterochromatin protein 1 forms distinct complexes to direct histone deacetylation and DNA methylation. Nat Struct Mol Biol 19:471–477 Huang Y (2002) Transcriptional silencing in Saccharomyces cer- evisiae and Schizosaccharomyces pombe. Nucleic Acids Res 30:1465–1482 Huisinga KL, Brower-Toland B, Elgin SC (2006) The contradictory definitions of heterochromatin: transcription and silencing. Chro- mosoma 115:110–122 Jenuwein T, Allis CD (2001) Translating the histone code. Science 293:1074–1080 Kale SP, Cary JW, Hollis N, Wilkinson JR, Bhatnagar D, Yu J, Cleveland TE, Bennett JW (2007) Analysis of aflatoxin regulato- ry factors in serial transfer-induced non-aflatoxigenic Aspergillus parasiticus. Food Addit Contam 24:1061–1069 Kale SP, Milde L, Trapp MK, Frisvad JC, Keller NP, Bok JW (2008) Requirement of LaeA for secondary metabolism and sclerotial pro- duction in Aspergillus flavus. Fungal Genet Biol 45:1422–1429 Keller NP, Hohn TM (1997) Metabolic pathway gene clusters in filamentous fungi. Fungal Genet Biol 21:17–29 Keller NP, Turner G, Bennett JW (2005) Fungal secondary metabolism —from biochemistry to genomics. Nat Rev Microbiol 3:937–947 Kennedy J, Auclair K, Kendrew SG, Park C, Vederas JC, Hutchinson CR (1999) Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis. Science 284:1368–1372 Kennerdell JR, Carthew RW (1998) Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway. Cell 95:1017–1026 Kershaw MJ, Talbot NJ (1998) Hydrophobins and repellents: proteins with fundamental roles in fungal morphogenesis. Fungal Genet Biol 23:18–33 Kimura M, Tokai T, O'Donnell K, Ward TJ, Fujimura M, Hamamoto H, Shibata T, Yamaguchi I (2003) The trichothecene biosynthesis gene cluster of Fusarium graminearum F15 contains a limited number of essential pathway genes and expressed non-essential genes. FEBS Lett 539:105–110 Kimura M, Tokai T, Takahashi-Ando N, Ohsato S, Fujimura M (2007) Molecular and genetic studies of Fusarium trichothecene biosyn- thesis: pathways, genes, and evolution. Biosci Biotechnol Bio- chem 71:2105–2123 Kornberg RD (1974) Chromatin structure: a repeating unit of histones and DNA. Science 184:868–871 Kornberg RD, Thomas JO (1974) Chromatin structure; oligomers of the histones. Science 184:865–868 Kosalkova K, Garcia-Estrada C, Ullan RV, Godio RP, Feltrer R, Teijeira F, Mauriz E, Martin JF (2009) The global regulator LaeA controls penicillin biosynthesis, pigmentation and sporulation, but not roquefortine C synthesis in Penicillium chrysogenum. Bio- chimie 91:214–225 Kouzarides T (2002) Histone methylation in transcriptional control. Curr Opin Genet Dev 12:198–209 Kouzarides T (2007) Chromatin modifications and their function. Cell 128:693–705 Kouzminova E, Selker EU (2001) dim-2 encodes a DNA methyltrans- ferase responsible for all known cytosine methylation in Neuros- pora. EMBO J 20:4309–4323 Laatsch H (2011) Antibase 2011: The Natural Compound Identifier, 1st edn.Wiley-VCH