Appl Microbiol Biotechnol (2010) 85:459–470 465 β1,2N-acetylglucosaminyltransferase I α-mannosidase I Mannose GlcNAc Galactose Fucose α-mannosidase II α-mannosidase III β1,4N-acetylglucosaminyltransferase III N-acetylglucosaminidase β1,4-galactosyltransferase α1,3-fucosyltransferase α1,6-fucosyltransferase N-acetylglucosaminidase N-acetylglucosaminidase α-mannosidase III α 1,3-mannosidase Fig. 3 Proposed N-glycan processing pathway in the T. ni cell line and silkworm larvae. Open and closed arrows indicate silkworm larvae and the T. ni cell line, respectively. N-glycans enclosed by dotted lines were not detected by the HPLC mapping Fig. 4 Blocking influenza virus infection using an α2,6- sialoglycopolypeptide. The α2,6-sialoglycopolypeptide was enzymatically synthesized from an (γ-PGA)-based glycopoly- peptides carrying α2,6- sialylated glycans acted as inhibitors of influenza virus because human viral HAs bind to α2,6-linked sialosides in the core glycan structures α2,6-Sialoglycopolypeptide Spacer Sialooligosaccharides γ-PGA Artificial glycopolymer Influenza virus Neuraminidase Blocking infection hemagglutinin Epithelium