D760 Nucleic Acids Research, 2012, Vol. 40, Database issue SUPPLEMENTARY DATA Supplementary Data are available at Supplementary Figures 1–2 and Table 1. NAR Online. ACKNOWLEDGEMENTS The authors thank Amos Bairoch, Kirill Degtyarenko, Henning Hermjakob and Eric Coissac for their help and encouragement in the early stages of this project, and Andrea Auchincloss and Alain Viari for critically reading the manuscript. FUNDING The Swiss Federal Government through the Federal Ofﬁce of Education and Science; the European Molecular Biology Laboratory (core funding); European Union (SLING: Serving Life-science Information for the Next Generation [226073], Microme: A Knowledge-Based Bioinformatics Framework for Microbial Pathway Genomics [222886-2], and ERC Advanced Grant SISYPHE); French government through ANR MIRI [BLAN08-1335497]; and the MetaNetX project of the Swiss SystemsX.ch initiative. Funding for open access charge: EMBL-EBI. Conﬂict of interest statement. None declared. 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