Nucleic Acids Research, 2007, Vol. 35, No. 20 6713 55. Vas,A., Mok,W. and Leatherwood,J. (2001) Control of DNA rereplication via Cdc2 phosphorylation sites in the origin recognition complex. Mol. Cell. Biol., 21, 5767–5777. 56. Carpenter,P.B., Mueller,P.R. and Dunphy,W.G. (1996) Role for a Xenopus Orc2-related protein in controlling DNA replication. Nature, 379, 357–360. 57. Bell,S.P., Kobayashi,R. and Stillman,B. (1993) Yeast origin recognition complex functions in transcription silencing and DNA replication. Science, 262, 1844–1849. 58. Fox,C.A., Loo,S., Dillin,A. and Rine,J. (1995) The origin recogni- tion complex has essential functions in transcriptional silencing and chromosomal replication. Genes Dev., 9, 911–924.