602 Current Genomics, 2010, Vol. 11, No. 8 (Table 1). Contd….. Akhabir and Sandford Gene SNP Chr. Loc. SNP Location Disease/Phenotype pValue Study Population N Refs. IL18RAP rs917997 103070568 intergenic Type 1 diabetes 8.03 x 10-5 IL18RAP rs917997 103070568 intergenic Crohn's disease IL18RAP rs917997 103070568 intergenic IBD Chr 2 - Type 2 diabetes LOD=4.53 Genetic linkage study African- American - - - - - - - - - - - - Candidate gene study Caucasian (Irish, British, American, Romanian, Danish, Norwegian, 8064 cases / Finnish) 9339 controls 2.2 x 10-6 Candidate gene study European 1689 cases / 6197 controls 1.9 x 10-8 Candidate gene study Dutch 1851 cases / 1936 controls Smyth et al. - N Engl J Med 2008 Wang et al. - Hum Mol genet 2010 Zher- nakova et al. - Am J Hum Genet 2008 Elbein et al. - Diabetes 2009 Grisoni et al. - BMC Med Genet 2009 Grisoni et al. - BMC Med Genet 2009 Reijmer- ink et al. - J Al- lergy Clin Immunol 2008 Reijmer- ink et al. - J Al- lergy Clin Immunol 2008 580 families 1416 cases / 1772 Con- trols 1416 cases / 1772 Con- trols Reijmer- ink et al. - J Al- lergy Clin 192 / 170 / Immunol 245 families 2008 IL18RAP 6 Tag SNPs Cardiovascular disease NS IL18R1 5 Tag SNPs Cardiovascular disease NS Haplo: IL1RL1 / rs10206753/rs12999364/rs14 IL18R1 20099 IL18R1 Haplo:rs1420099/rs1558627/r s2270297 IL1RL1 Haplo:rs1921622/rs1861246/r s10206753 Candidate gene study European Candidate gene study European Candidate gene study Candidate gene study BHR 0.006 Dutch 179 families Asthma 0.002 Dutch 180 families BHR / asthma / Total IgE 0.0009 / 0.0008 / 0.007 Candidate gene study Dutch