E1686 Sheynin et al. SUPP. METHODS Additional Bedouin family clinical data The patients did not have bouts of unexplained fever (but had fever during infections), they had no dysphagia or vomiting. They had tears during emotional upset and had normal sweating. All had good bladder control (the youngest patient has nocturnal enuresis). One of the patients had a corneal abscess treated with parenteral antibiotics followed by tarsoraphy. According to the parents the children were indifferent to some flavours such as to an excess of salty food. (They appreciate food by vision). The patients were considered by their parents to have a well developed cognitive state, the elder one attended school. On examination the children were co-operative with well developed verbal skills and normal voices. They were oriented to place, time and to people. The ocular movements were normal, the pupils were round, equal and reacting to direct and consensual light with the presence but reduced corneal reflex and with lacrimation. The fundoscopic examinations were normal. Facial movements were normal. The tongues were normal with no fasciculation and with the presence of fungiform papillae. The uvulas were at the midline with intact gag reflex and swallowing. The tone was mildly reduced with normal bulk of muscles. The strength at both upper and lower limbs was 5/5. Deep tendon reflexes and plantar responses were normal. Cerebellar functions were normal. The gait and stance were normal. A mild laxity of joints was noticed. The motor conduction studies of the right peroneal and left tibial nerves showed normal distal latencies amplitudes and velocities. All patients had sweat in the armpits and on the palmar regions. There was no superficial peripheral nerve enlargement on palpation. The patients were tested by the following methods: Motor and sensory nerve conduction studies as well as the sympathetic skin responses were performed on a Keypoint machine (Medtronic, Copenhagen, Denmark) using standard methods. The motor nerve studies included the peroneal, tibial and median nerves. The sensory studies included the medial planar and median nerves. The sympathetic skin responses were recorded from the palms of hands. Heart rate variability was evaluated during resting and deep breath. Schirmer test was performed by applying film in the tarsal plate and measuring the length of wet film. Sweat test was performed by applying a scopolamine patch. Histamine test was performed by pin-pricking with histamine and measuring the flare responses. The results of the tests: The motor conduction studies of tibial, peroneal and median nerves showed normal distal latencies amplitudes and velocities. The sensory studies of the medial plantar nerves showed normal latencies amplitudes and velocities. Sympathetic skin responses of the median nerves recorded from the palm were normal in all patients to electrical stimulation of the palm. Sweat test, Schirmer test and Histamine test were all normal.