8 [57] D. Bryant, L. Becker, J. Richardson et al., “Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-α,” Circulation, vol. 97, no. 14, pp. 1375–1381, 1998. [58] R. Brouns and P. P. De Deyn, “Neurological complications in renal failure: a review,” Clinical Neurology and Neurosurgery, vol. 107, no. 1, pp. 1–16, 2004. [59] M. Liu, Y. Liang, S. Chigurupati et al., “Acute kidney injury leads to inﬂammation and functional changes in the brain,” Journal of the American Society of Nephrology, vol. 19, no. 7, pp. 1360–1370, 2008. [60] R. F. Schwabe, B. Schnabl, Y. O. Kweon, and D. A. Brenner, “CD40 activates NF-κB and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells,” Journal of Immunology, vol. 166, no. 11, pp. 6812–6819, 2001. [61] F. Golab, M. Kadkhodaee, M. Zahmatkesh et al., “Ischemic and non-ischemic acute kidney injury cause hepatic damage,” Kidney International, vol. 75, no. 8, pp. 783–792, 2009. [62] C. J. Carrico, J. L. Meakins, J. C. Marshall, D. Fry, and R. V. Maier, “Multiple-organ-failure syndrome,” Archives of Surgery, vol. 121, no. 2, pp. 196–208, 1986. [63] J. A. Clark and C. M. Coopersmith, “Intestinal crosstalk: a new paradigm for understanding the gut as the ”motor” of critical illness,” Shock, vol. 28, no. 4, pp. 384–393, 2007. [64] H. T. Hassoun, B. C. Kone, D. W. Mercer, F. G. Moody, N. W. Weisbrodt, and F. A. Moore, “Post-injury multiple organ failure: the role of the gut,” Shock, vol. 15, no. 1, pp. 1–10, 2001. [65] M. P. Fink and R. L. Delude, “Epithelial barrier dysfunction: a unifying theme to explain the pathogenesis of multiple organ dysfunction at the cellular level,” Critical Care Clinics, vol. 21, no. 2, pp. 177–196, 2005. [66] R. S. Martin, S. Panese, M. Virginillo et al., “Increased secre- tion of potassium in the rectum of humans with chronic renal failure,” American Journal of Kidney Diseases, vol. 8, no. 2, pp. 105–110, 1986. [67] D. Gimelreich, M. M. Popovtzer, H. Wald, G. Pizov, Y. Berlatzky, and D. Rubinger, “Regulation of ROMK and channel-inducing factor (CHIF) in acute renal failure due to ischemic reperfusion injury,” Kidney International, vol. 59, no. 5, pp. 1812–1820, 2001. [68] H. Rabb, Z. Wang, G. Postler, and M. Soleimani, “Possible molecular basis for changes in potassium handling in acute renal failure,” American Journal of Kidney Diseases, vol. 35, no. 5, pp. 871–877, 2000. International Journal of Nephrology