Evidence-Based Complementary and Alternative Medicine Table 1: Eﬀects of Mentha piperita and simethicone on infantile colic. Mentha piperita Simethicone n % (SD) % (SD) P-value Variables Mother evaluation Slightly improved 12 Greatly improved 6 Completely improved 12 40.0 20.0 40.0 Daily colic episodes Daily colic duration Duration of the colic after medication 1.7 (±0.5) 114 (±26) 17.0 (13.8) ∗ Fisher’s Exact Test ∗∗Mann-Whitney Test. n 12 5 13 1.5 109 40.0 0.271∗ 16.7 43.3 (±0.6) 0.456∗ (±29) 0.787∗∗ 16.0 (10.0) 0.860∗∗ antagonism [20, 21]. A study with peppermint oil capsule seemed to reduce the pain that children experienced during the acute phases of irritable bowel syndrome [22–24]. Savino et al. in a randomized trial showed that colic in breastfed infant improves with an extract based on Matricaria recutita, Foeniculum vulgare, and Melissa oﬃcinalis [25]. To our best knowledge, this is the ﬁrst time that a clinical trial study evaluated the eﬃcacy of Mentha piperita on the infantile colic treatment. For diseases on some aspects of physiopathology are unknown as infantile colic, the use of this medication on the same patient oﬀers some advantages. In this study, we used a double-blind crossover design. This design in this study oﬀers the control of several variables that may inﬂuence the presence of colic as genetic factors, environmental, emotional, and eating maternal habits. We also include only exclusively breastfeeding infants for better controlling of food variable. We believe that all this con- tributed to strengthening our ﬁndings. Our study has some limitations. At ﬁrst, the natural history of infantile colic is to improve with time. Although we have used a crossover design, the possible eﬀect of time on the improvement of infantile colic could not be totally eliminated. 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