Rahimdel et al. References 1 Wetter TC, Pollmächer T. Restless legs and periodic leg movements in sleep syndromes. J Neurol 1997; 244:S37-45. [9112588] [http://dx. doi.org/10.1007/BF03160570] 2 Silber MH, Ehrenberg BL, Allen RP, Buchfuhrer MJ, Earley CJ, Hening WA, Rye DB; Medical Advisory Board of the Restless Legs Syn- drome Foundation. An algorithm for the management of restless legs syndrome. Mayo Clin Proc 2004; 79:916-22. [15244390] [http://dx. doi.org/10.4065/79.7.916] 3 Bayard M, Avonda T, Wadzinski J. Restless legs syndrome. Am Fam Physician 2008;78:235-40. [1869 7508] 4 Högl B, Paulus W, Clarenbach P, Trenkwalder C. Restless legs syn- drome: Diagnostic assessment and the advantages and risks of dopa- minergic treatment. J Neurol 2006; 253:IV22-8. [16944353] [http://dx.doi. org/10.1007/s00415-006-4005-3] 5 Desai AV, Cherkas LF, Spector TD, Williams AJ. Genetic influences in self-reported symptoms of obstruc- tive sleep apnea and restless legs: a twin study. Twin Res 2004;7:589-95. [15607009] [http://dx.doi.org/10.13 75/1369052042663841] 6 Chen S, Ondo WG, Rao S, Li L, Chen Q, Wang Q. Genomewide link- age scans identifies a novel suscepti- bility locus for restless legs syndrome on chromosome 9p. Am J Hum Genet 2004;74:876-85. [15077200] [http:// dx.doi.org/10.1086/420772] 7 Winkelmann J, Muller-Myhsok B, Wittchen HU, Hock B, Prager M, Pfister H, Strohle A, Eisensehr I, Dichgans M, Gasser T, Trenkwalder C. Complex segregation analysis of restless legs syndrome provides ev- idence for an autosomal dominant mode of inheritance in early age at onset families. Ann Neurol 2002; 52:297-302. [12205641] [http://dx. doi.org/10.1002/ana.10282] 8 Bonati MT, Ferini-Strambi L, Aridon P, Oldani A, Zucconi M, Casari G. Autosomal dominant restless legs syndrome maps on chromosome 14q. Brain 2003;126:1485-92. [12 764067] [http://dx.doi.org/10.1093/ brain/awg137] 9 Montagna P. The treatment of rest- less legs syndrome. Neurological Science 2007;28:S61-66. [http://dx. doi.org/10.1007/s10072-007-0739-7] 10 Zucconi M, Manconi M, Ferini Strambi L. Aetiopathogenesis of restless legs syndrome. Neurological Sci- ence 2007;28:47-52. [http://dx.doi. org/10.1007/s10072-007-0737-9] 18 11 Mrowka M, Jöbges M, Berding G, Schimke N, Shing M, Odin P. Com- puterized movement analysis and beta-CIT-SPECT in patients with restless legs syndrome. J Neural Transm 2005;112:693-701. [155174 34] [http://dx.doi.org/10.1007/s007 02-004-0217-9] 12 Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Mont- plaisi J; Restless Legs Syndrome Diagnosis and Epidemiology work- shop at the National Institutes of Health; International Restless Legs Syndrome Study Group. Restless legs syndrome: diagnostic criteria, special considerations, and epide- miology. A report from the restless legs syndrome diagnosis and epi- demiology workshop at the National Institutes of Health. Sleep Med 2003;4:101-19. [14592341] [http:// dx.doi.org/10.1016/S1389-9457(03) 00010-8] 13 Walters AS, LeBrocq C, Dhar A, Hening W, Rosen R, Allen RP, Trenkwalder C; International Rest- less Legs Syndrome Study Group. Validation of the international rest- less legs syndrome study group rat- ing scale for restless legs syndrome. Sleep Med 2003;4:121-32. [1459 2342] [http://dx.doi.org/10.1016/S 1389-9457(02)00258-7] 14 Zafar KS, Siddiqui A, Sayeed I, Ahmad M, Salim S, Islam F. Dose- dependent protective effect of sele- nium in rat model of Parkinson dis- ease: neurobehavioral and neuro- chemical evidences. J Neurochem 2003;84:438-46. [12558963] [http:// dx.doi.org/10.1046/j.1471-4159.200 3.01531.x] 15 Trenkwalder C, Hening WA, Monta- gna P, Oertel WH, Allen RP, Wal- ters AS, Costa J, Stiasny-Kolster K, Sampaio C. Treatment of restless legs syndrome: An evidence-based review and implications for clinical practice. Mov Disord 2008;23:2267- 302. [18925578] [http://dx.doi.org/ 10.1002/mds.22254] 16 Kohrle J, Jakob F, Contempre B, Dumont JE. Selenium, the thyroid and the endocrine system. Endocr Rev 2005;26:944-84. [16174820] [http:// dx.doi.org/10.1210/er.2001-0034] 17 Hogue DE. Selenium. J Dairy Sci 1970;53:1135-7. [4918952] [http:// dx.doi.org/10.3168/jds.S0022-0302 (70)86356-1] 18 Alizadeh M, Daneghian S, Ghaffari A, Ostadrahimi AR, Safaeiyan AR, Estakhri R, Pourghassem Gargari B. The effect of hypocaloric diet en- riched in legumes with or without L- arginine and selenium on anthro- pometric measures in central obese women. J Res Med Sci 2010; 15:331-43. [21526106] 19 Boskabadi H, Rezagholizade Omran F, Tara F, Rayman MP, Ghayour- Mobarhan M, Sahebkar A, Tavallaie S, Shakeri MT, Alamdari DH, Kiani M, Razavi BS, Oladi M, Ferns G. The Effect of Maternal Selenium Supplementation on Pregnancy Outcome and the Level of Oxidative Stress in Neonates. Iran Red Cres- cent Med J 2010;12:254-259. 20 Patrick L. Selenium biochemistry and cancer: a review of the literature. Altern Med Rev 2004;9:239-58. [15 387717] 21 Ge K, Yang G. The epidemiology of selenium deficiency in the etiological study of endemic diseases in China. Am J Clin Nutr 1993;57:259S-263S. [8427200] 22 Diplock AT. Indexes of selenium in human populations. Am J Clin Nutr 1993;57:256S-258S. [8427199] 23 Khan HA. Selenium partially reverses the depletion of striatal dopamine and its metabolites in MPTP-treated C57BL mice. Neurochem Int 2010; 57:489-91. [20619308] [http://dx.doi. org/10.1016/j.neuint.2010.06.020] 24 Talas ZS, Ozdemir I, Gok Y, Ates B, Yilmaz I. Role of selenium com- pounds on tyrosine hydroxylase ac- tivity, adrenomedullin and total RNA levels in hearts of rats. Regul Pept 2010;159:137-41. [19706312] [http:// dx.doi.org/10.1016/j.regpep.2009.08 .009] 25 Castaño A, Ayala A, Rodriguez- Gomez JA, de la Cruz CP, Revilla E, Cano J, Machado A. Increase in dopamine turnover and tyrosine hy- droxylase enzyme in hippocampus of rats fed on low selenium diet. J Neu- rosci Res 1995;42:684-91. [860 0301] [http://dx.doi.org/10.1002/jnr. 490420511] 26 Tara F, Rayman MP, Boskabadi H, Ghayour-Mobarhan M, Sahebkar A, Alamdari DH, Razavi BS, Tavallaie S, Azimi-Nezhad M, Shakeri MT, Oladi M, Yazarlu O, Ouladan S, Sangani MT, Omran FR, Ferns G. Pro oxidant-antioxidant balance in pregnancy: a randomized double- blind placebo-controlled trial of se- lenium supplementation. J Perinat Med 2010;38:473-8. [20629489] [http:// dx.doi.org/10.1515/JPM.2010.068] 27 Lippman SM, Klein EA, Goodman PJ, Lucia MS, Thompson IM, Ford LG, Parnes HL, Minasian LM, Gazi- ano JM, Hartline JA, Parsons JK, Bearden JD 3rd, Crawford ED, Goodman GE, Claudio J, Winquist E, Cook ED, Karp DD, Walther P, WWW.ircmj.com Vol 14 January 2012