UCP-1 A-3826G Polymorphism and HDL-C in Relation to Obesity J Clin Med Res • 2011;3(6):319-324 genetic variations of the other types of uncoupling proteins such as UCP-2 and UCP-3 [22, 23], no data on such types of uncoupling proteins were available in this study. Additional studies with larger populations, prospective designs and var- ious genetic polymorphisms are needed. In summary, carrying the G/G genotype of the UCP-1 gene A-3826G polymorphism was an independent and sig- niﬁcant factor positively associated with low HDL-choles- terolemia in obese subjects, and in contrast, carrying the G/G genotype was a relatively protective factor associated with low HDL-cholesterolemia in non-obese subjects. 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