thought that the anti-allergic actions and the strengthening of the gastrointestinal peristalsis change in parallel. It has been reported that a serotonin receptor participates in the transmission of CRF.(21) In addition, the serotonin-stimulated neurons have nerve terminals to mast cells, and induced the activation of the mast cells by nerve stimulation.(22) The gastrointestinal tract then shifts to the Th2 type response following the activation of the mast cells, and as a result, may act on allergic suppression. It is thought that the CRF-serotonin neuron-mast cell system may explain why the blood levels of ACTH and cortisol increase, and why an anti- allergic reaction is induced by the smell of seirogan. An opioid receptor participates in the normalization of the peristaltic movement of the bowels, but Seirogan itself does not affect the opioid receptor.(23) On the other hand, the smell of the compound acts on an opioid receptor through sensory nerves, and induces an antiallergic action. In addition, there is an opioid receptor to the Th cells of the bowels, which induces the differen- tiation to Th2 cells and reinforces the expression of Th2 cyto- kines.(24) Therefore, the smell of Seirogan acts on the opioid receptor of the bowels and may be responsible for the immuno- modulation. In addition, chemical contact allergy induced by dinitrofluoro- benzene, trinitrofluorobenzene and oxazolone is a cell-mediated immune response mediated by IFN-γ producing Th/Tc1 cells.(25) However, Tang et al.(26) found that the FITC-induced CHS References 1 Ogata N, Toyoda T, Shibata T. Suppression of intestinal smooth muscle con- traction by phenolic compounds. 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In summary, the current study suggested that the FITC- and oxazolone-induced CHS response could be inhibited by oral administration of coated Seirogan and the smell of uncoated Seirogan. Therefore, the FITC-induced CHS allergic response was low in comparison with the oxazolone-induced CHS. The FITC-induced CHS model shows an inflammatory skin and colon pathology reproducing all the key features of human atopic dermatitis, including what appears to be a Th2 driven immune response. Therefore, the smell of the Seirogan may effectively prevent and/or cure the symptoms of atopic dermatitis. Conflict of Interest No potential conflicts of interest were disclosed. 16 Writz PH, von Kanel R, Kunz-Ebrecht S, Ehlert U, Fischer JE. Reduced glucocorticoid sensitivity of monocyte interleukin-6 release in male employes with high plasma levels of tumor necrosis factor-alpha. Life Sci 2004; 75: 1– 10. 17 Harrist A, Beech RD, King SL, et al. 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