Zhang et al. Journal of Experimental & Clinical Cancer Research 2010, 29:155 http://www.jeccr.com/content/29/1/155 Page 5 of 5 8. Nashikawa M, Nishiguchi S, Shiomi S, Tamori A, Koh N, Takeda T, Kubo S, Hirohashi K, Kinoshita H, Sato E, Inoue M: Somatic mutation of mitochondrial DNA in cancerous and noncancerous liver tissue in individuals with hepatocellular carcinoma. Cancer Res 2001, 61:1843-1845. 9. Sanchez-Cespedes M, Parrella P, Nomoto S, Cohen D, Xiao Y, Esteller M, Jeronimo C, Jordan RC, Nicol T, Koch WM, Schoenberg M, Mazzarelli P, Fazio VM, Sidransky D: Identification of a mononucleotide repaet as a major target for mitochondrial DNA alterations in human tumors. Cancer Res 2001, 61:7015-7019. 10. Taanman JW: The mitochondrial genome: structure, transcription, translation and replication. Biochim Biophys Acta 1999, 1410:103-123. 11. Navaglia F, Basso D, Fogar P, Sperti C, Greco E, Zambon CF, Stranges A, Falda A, Pizzi S, Parenti A, Pedrazzoli S, Plebani M: Mitochondrial DNA D- loop in pancreatic cancer: somatic mutations are epiphenomena while the germline 16519 T variant worsens metabolism and outcome. Am J Clin Pathol 2006, 126:593-601. 12. Wang L, Bamlet WR, de Andrade M, Boardman LA, Cunningham JM, Thibodeau SN, Petersen GM: Mitochondrial genetic polymorphisms and pancreatic cancer risk. Cancer Epidemiol Biomarkers Prev 2007, 16:1455-1459. 13. Wang L, McDonnell SK, Hebbring SJ, Cunningham JM, St Sauver J, Cerhan JR, Isaya G, Schaid DJ, Thibodeau SN: Polymorphisms in mitochondrial genes and prostate cancer risk. Cancer Epidemiol Biomarkers Prev 2008, 17:3558-3566. 14. Bai RK, Leal SM, Covarrubias D, Liu A, Wong LJ: Mitochondrial genetic background modifies breast cancer risk. Cancer Res 2007, 67:4687-4694. 15. Lee HC, Li SH, Lin JC, Wu CC, Yeh DC, Wei YH: Somatic mutations in the D-loop and decrease in the copy number of mitochondrial DNA in human hepatocellular carcinoma. Mutant Res 2004, 547:71-78. 16. Stoneking M: Hypervariable sites in the mtDNA control region are mutational hotspots. Am J Hum Genet 2000, 67:1029-1032. 17. Bandy B, Davision AJ: Mitochondrial mutations may increase oxidtaive stress: implications for carcinogenesis and aging? Free Radic Biol Med 1990, 8:523-539. 18. Gille JJ, Joenje H: Cell culture models for oxidative stress: Superoxide and hydrogen peroxidative versus normobaric heperoxia. Mutat Res 1992, 275:405-414. 19. Shigenaga MK, Hagen TM, Ames BN: Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci USA 1994, 91:10771-10778. 20. Dement GA, Maloney SC, Reeves R: Nuclear HMGA1 nonhistone chromatin proteins directly influence mitochondrial transcription, maintenance, and function. Exp Cell Res 2007, 313:77-87. doi:10.1186/1756-9966-29-155 Cite this article as: Zhang et al.: Single nucleotide polymorphisms in the mitochondrial displacement loop and outcome of esophageal squamous cell carcinoma. Journal of Experimental & Clinical Cancer Research 2010 29:155. Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color ﬁgure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit