Journal of Experimental & Clinical Cancer Research 2008, 27:31 http://www.jeccr.com/content/27/1/31 19. Li Y, Shi TZ: Mechanisms of Kanglaite induced apoptosis in human cancer cells. Chinese Journal of Clinical Oncology 2002, 29:869-872. 20. Mizuta M, Nakajima H, Mizuta N, Kitamura Y, Nakajima Y, Hashimoto S, Matsuyama H, Shime N, Amaya F, Koh H, Ishizaka A, Magae J, Tanuma SI, Hashimoto S: Fas ligand released by activated mono- cytes causes apoptosis of lung epithelial cells in human acute lung injury model in vitro. Biol Pharm Bull 2008, 31:386-390. 21. Bossowski A, Czarnocka B, Stasiak-Barmuta A, Bardadin K, Urban M, Dadan J: Analysis of Fas, FasL and Caspase-8 expression in thyroid gland in young patients with immune and non- immune thyroid diseases. Endokrynol Pol 2007, 58:303-313. 22. Iwase M, Watanabe H, Kondo G: Enhanced susceptibility of oral squamous cell carcinoma cell lines to FAS-mediated apopto- sis by cisplatin and 5-fluorouracil. Int J Cancer 2003, 106:619-625. 23. Han SX, Zhu Q, Du BR: The mechanism of coixenolide-induced apoptosis in human cervical cancer cells. Oncology 2002, 22:481-482. 24. Huang T, Lv G, Gao DX, Wang YF: Experimental studyl on apop- tosis of osteosarcoma cells induced by Kang-Lai-Te com- bined with doxorubicin. hinese Journal of Histochemistry and Cytochemistry 2005, 14:648-652. 25. Eguchi Y, Shimizu S, Tsujimoto Y: Molecular biology of apoptosis. Rinsho Byori 1997, 45:470-476. 26. Aprigliano I, Dudas J, Ramadori G, Saile B: Atorvastatin induces apoptosis by a caspase-9-dependent pathway: an in vitro study on activated rat hepatic stellate cells. Liver Int 2008, 28:546-557. 27. Porter AG, Janicke RU: Emerging roles of caspase-3 in apopto- sis. Cell Death Differ 1999, 6:99-104. 28. Roberto da Costa RP, Serrao PM, Monteiro S, Pessa P, Silva JR, Fer- reira-Dias G: Caspase-3-mediated apoptosis and cell prolifer- ation in the equine endometrium during the oestrous cycle. Reprod Fertil Dev 2007, 19:925-932. 29. Williams BL, Hornig M, Yaddanapudi K, Lipkin WI: Hippocampal poly(ADP-Ribose) polymerase 1 and caspase 3 activation in neonatal bornavirus infection. J Virol 2008, 82:1748-1758. 30. Flynn AN, Buret AG: Caspases-3, -8, and -9 are required for induction of epithelial cell apoptosis by enteropathogenic E. coli but are dispensable for increased paracellular permea- bility. Microb Pathog 2008, 44:311-319. 31. Chai WS, Zhu XM, Li SH, Fan JX, Chen BY: Role of Bcl-2 family members in caspase-3/9-dependent apoptosis during Pseu- domonas aeruginosa infection in U937 cells. Apoptosis 2008, 13:833-843. 32. Tichý A, Záskodová D, Pejchal J, Rezácová M, Osterreicher J, Vávrová J, Cerman J: Gamma irradiation of human leukaemic cells HL- 60 and MOLT-4 induces decrease in Mcl-1 and Bid, release of cytochrome c, and activation of caspase-8 and caspase-9. Int J Radiat Biol 2008, 84:523-530. 33. Wang JJ, Sun XJ, Shen WJ: Apoptosis Induced by Kang-Lai-Te Injection and Its Relation with expression of p53, bcl-2 in Renal Cancer Cell Lines. Chinese Journal of Clinical Oncology and Rehabilitation 1999, 6:34-36. 34. Yuan YZ, Bao Y, Xia L: The study on KLT-induced apoptosis of human pancreatic cancer Paru-8988 cell which detected by Gene chip. Chinese Journal of Digestion 2004, 24:451-454. 35. Kemp C, Alberti VN, de Lima GR, de Carvalho FM: How should PCNA be assessed? Total of stained cells or only the most intensely stained ones? Sao Paulo Med J 1998, 116:1667-1674. 36. Horita K, Yamaguchi A, Hirose K, Ishida M, Noriki S, Imamura Y, Fukuda M: Prognostic factors affecting disease-free survival rate following surgical resection of primary breast cancer. Eur J Histochem 2001, 45:73-84. 37. Bi CM, Zhang SQ, Zhang Y, Peng SY, Wang L, An ZX, Qi A, Lv N: Immortalization of bovine germ line stem cells by c-myc and hTERT. Anim Reprod Sci 2007, 100:371-378. 38. Schmidt EV: The role of c-myc in cellular growth control. Onco- gene 1999, 18:2988-2996. 39. Winters ZE, LeeK RD, Bradburn MJ, Norbury CJ: Harris AL. Cyto- plasmic p21WAF1/CIP1 expression is correlated with HER- 2/neu in breast cancer and is an independent predictor of prognosis. Breast Cancer Res 2003, 5:242-249. 40. Bao Y, Xia L, Yuan YZ: Effects of KLT on cell cycle and related gene expression in Patu-8988 cells. Chinese Journal of pancreatop- athy 2004, 4:82-85. 41. Manu KA, Kuttan G: Ursolic acid induces apoptosis by activat- ing p53 and caspase-3 gene expressions and suppressing NF- kappaB mediated activation of bcl-2 in B16F-10 melanoma cells. Int Immunopharmacol 2008, 8:974-981. 42. Chou JJ, Li H, Salvesen GS, Yuan J, Wagner G: Solution structure of BID, an intracellular amplifier of apoptotic signaling. Cell 1999, 96:615-624. 43. Lu Y, Wu LQ: Efficacy of intra-tumor injection of Xiao-Zhi- Ling on transplanted hepatoma in rats. World J Gastroenterol 2003, 9:2121-2124. 44. Wu LQ, Lu Y, Lu HJ: Efficacy of intra-tumor injection of Kang- Lai-Te in treating transplanted hepatoma in rats. Hepatobiliary & Pancreatic Diseases International 2004, 3:580-584. 45. Li X, Wu XX, Li PW: The clinical research about kanglaite injection treatment on primary hepatic carcinoma. Chinese Journal of Clinical Oncology 1999, 26:475-476. 46. Ran JH, Zhang JH, Wang X: The influence on postoperative immune function of colorectal cancer patients which caused by KLT. Chinese Journal of Clinical Oncology and Rehabilitation 1999, 6:20-22. 47. Zhu PS, Duan LH: The clinical observation about KLT com- bined with CEP program treatment on the advanced lung cancer. Journal of Practical Oncology 1999, 14:311-312. Publish with Bio Med Central and every scientist can read your work free of charge "BioMed Central will be the most significant development for disseminating the results of biomedical research in our lifetime." Sir Paul Nurse, Cancer Research UK Your research papers will be: available free of charge to the entire biomedical community peer reviewed and published immediately upon acceptance cited in PubMed and archived on PubMed Central yours — you keep the copyright Submit your manuscript here: http://www.biomedcentral.com/info/publishing_adv.asp BioMedcentral Page 5 of 5 (page number not for citation purposes)