Chantaren et al risk to AMD through the mitochondrial pathway.31 Additional analysis of the LOC387715/ARMS2 protein with Ala or Ser codon 69 and its function in vivo are needed to better under- stand its contribution to PCV or AMD pathogenesis. Limitations in this study include the assessments of only three major SNPs associated with AMD. Other SNPs may also be associated with PCV. To the authors’ knowledge there has been no genome-wide study to document other PCV-associated SNPs that may not be associated with AMD. The compiled data from previously published studies were set up only for comparison with the results of this study. The aim was not to conduct a meta-analysis of association between the three SNPs and PCV; therefore, there were no strong criteria for inclusion and exclusion of the studies into the compiled data. Although the results of this study suggest a trend toward association between the three SNPs and PCV, more data from other Asian populations and other ethnic groups are necessary. Cigarette smoking has been found to be associated with PCV, and there was possible interaction between the Y402H and cigarette smoking on PCV.17 However, some studies on interaction between cigarette smoking and SNPs in AMD showed contradictory results.32–35 Smoking history was sur- veyed in the present study’s participants, but the data were so varied and unreliable that they were not used for analysis. This is another limitation of this study. In conclusion, the major AMD-susceptibility genes, CFH with Y402H and I62V and ARMS2 with A69S, are associated with PCV in a Thai population. The results are in concordance with those from the compiled data obtained from previous association studies in other Asian populations. This suggests that AMD and PCV may share the same genetic predisposition. 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