NEENA DESAI ef a/. Kurza, M.(1994) Clozapine dose in United States and Europe, implication for therapeutic and adverse effects. Journal of Clinical Psychiatry, 55, (suppl, 9), 78-81. Kane,J., Honizfeld.G., Singer.J. & Meltzer, H.(1988) Clozapine for treatment resistant schizophrenics, a double blind comparison with chlorpromazine. Archives of General Psychiatry, 45, 789-796. Kane.J.M. (1992) Clinical efficacy of clozapine in treatment refractory schizophrenia an overview. British Journal of Psychiatry, 160, (suppl, 17), 41-45. Kane.J.M. (1993) Newer antipsychotic drugs, a review of their pharmacology and therapeutic potential. Drugs, 46, 585-593. Kaplan, H.I. & Seddock, B.J.(1996) Clozapine: Pocket Handbook of Psychiatric Drug Treatment, 2nd Indian Reprint, (Eds.) Cancro.R. & Sussman.N. pp 83-86, New Delhi : B.I. Publications Pvt. Limited. Kay.S.G., Opier.L.D. & Lindenmayer, J.R. (1988) reliability and validity of the Positive and Negative Syndrome Scale for schizophrenia. Psychiatry Research, 23, 99-110. Klik.J., Krausova.J.K. & Marcsova.H.V. (1976) Experiences with Clozapine in practice at a psychiatric hospital. Czeskoslovenska Psychiatrica, 72, 197-200. Lapierre.Y.D., Ghadirian.A., St.Laurent, J. & Chaudhury,R.P.(1980) Clozapine in acute schizophrenia, efficacy and toxicity. Current Therapeutic Research, 27, 391-400. Lieberman,J.A., Johns.C.A., Kane.J.M., Rai.K., Pisicotta.A.V., Saltz.D.L. & Howard,A. (1988) Clozapine induced agranulocytosis, non cross reactivity with other psychotropic drugs. Journal of Clinical Psychiatry, 50, 329-338. Lindstrom,L.H.(1988) The effect of long term treatment of clozapine for upto 13 years. Acta Psychiatrica Scandinavica, 77, 524-529. Mattes,H.A.(1989) Clozapine for refractory schizophrenia, as open study of. 14 patients treated upto 2 years. Journal of Clinical Psychiatry, 50, 389-391. Meltzer.H.Y., Bastani.B., Kwon.K.Y. Ramirez.L.G. & Burnett,S.(1989) A prospective study of clozapine in treatment resistant schizophrenic patientsr Preliminary report. Psychopharmacology, 99, 568-572. Meltzer,H.Y.(1992) Dimensions of outcome with clozapine. British Journal of Psychiatry, 160, (suppl 17), 46-53. Overall,J.E. & Gorham,D.R.(1962) The Brief Psychiatric Rating Scale. Psychological Report, 10, 799-812. Umbricht.D.G.S, Pollark.S. & Kane,J.M. (1994) Clozapine and weight gain. Journal of Clinical Psychiatry, 55,9, 157-196. NEENA DESAI', MD.DPM, Lecturer, VANIJAIN, llird year Resident, SUPRIYA GHALSASI, llnd year Resident, MADHUSUDAN DALVI, 1st year Resident, & SEJALKELKAR, 1st year Resident, Department of Psychiatry, LTMMC&LTMGH, SION-400022. C* 2/201, Kashi Bhuvan, Anant Waman Vartak Marg, VUe Parte (East), Muinbai-400 057) * Correspondence 340