signal-speciﬁc transrepression by LXRs and PPARgamma. Mol. Cell, 25, 57–70. 33. Matsuoka,H., Fujimura,T., Hayashi,M., Matsuda,K., Ishii,Y., Aramori,I. and Mutoh,S. (2007) Disruption of HDAC4/N-CoR complex by histone deacetylase inhibitors leads to inhibition of IL-2 gene expression. Biochem. Pharmacol., 74, 465–476. 34. Zhang,C.L., McKinsey,T.A. and Olson,E.N. (2002) Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle diﬀerentiation. Mol. Cell. Biol., 22, 7302–7312. 35. Gregoire,S. and Yang,X.J. (2005) Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors. Mol. Cell. Biol., 25, 2273–2287. 36. Zhao,X., Sternsdorf,T., Bolger,T.A., Evans,R.M. and Yao,T.P. (2005) Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modiﬁcations. Mol. Cell. Biol., 25, 8456–8464. 37. Chauchereau,A., Mathieu,M., de Saintignon,J., Ferreira,R., Pritchard,L.L., Mishal,Z., Dejean,A. and Harel-Bellan,A. (2004) HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF. Oncogene, 23, 8777–8784. 38. Basile,V., Mantovani,R. and Imbriano,C. (2006) DNA damage promotes histone deacetylase 4 nuclear localization and repression of G2/M promoters, via p53 C-terminal lysines. J. Biol. Chem., 281, 2347–2357. 39. Saunders,M.A., Sansores-Garcia,L., Gilroy,D.W. and Wu,K.K. (2001) Selective suppression of CCAAT/enhancer-binding protein beta binding and cyclooxygenase-2 promoter activity by sodium salicylate in quiescent human ﬁbroblasts. J. Biol. Chem., 276, 18897–18904. 40. Timchenko,N.A., Welm,A.L., Lu,X. and Timchenko,L.T. (1999) CUG repeat binding protein (CUGBP1) interacts with the 50 region of C/EBPbeta mRNA and regulates translation of C/EBPbeta iso- forms. Nucleic Acids Res., 27, 4517–4525. 41. Gill,G. (2005) Something about SUMO inhibits transcription. Curr. Opin. Genet. Dev., 15, 536–541. 42. Zhao,X., Ito,A., Kane,C.D., Liao,T.S., Bolger,T.A., Lemrow,S.M., Means,A.R. and Yao,T.P. (2001) The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellu- lar traﬃcking. J. Biol. Chem., 276, 35042–35048. 43. Wang,A.H. and Yang,X.J. (2001) Histone deacetylase 4 possesses intrinsic nuclear import and export signals. Mol. Cell. Biol., 21, 5992–6005. 44. Deng,W.G., Zhu,Y. and Wu,K.K. (2004) Role of p300 and PCAF in regulating cyclooxygenase-2 promoter activation by inﬂammatory mediators. Blood, 103, 2135–2142. 45. Grimm,S.L., Contreras,A., Barcellos-Hoﬀ,M.H. and Rosen,J.M. (2005) Cell cycle defects contribute to a block in hormone-induced Nucleic Acids Research, 2008, Vol. 36, No. 19 6079 mammary gland proliferation in CCAAT/enhancer-binding protein (C/EBPbeta)-null mice. J. Biol. Chem., 280, 36301–36309. 46. Lamb,J., Ramaswamy,S., Ford,H.L., Contreras,B., Martinez,R.V., Kittrell,F.S., Zahnow,C.A., Patterson,N., Golub,T.R. and Ewen,M.E. (2003) A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer. Cell, 114, 323–334. 47. Lane,M.D., Tang,Q.Q. and Jiang,M.S. (1999) Role of the CCAAT enhancer binding proteins (C/EBPs) in adipocyte diﬀerentiation. Biochem. Biophys. Res. Commun., 266, 677–683. 48. Schrem,H., Klempnauer,J. and Borlak,J. (2004) Liver-enriched transcription factors in liver function and development. Part II: the C/EBPs and D site-binding protein in cell cycle control, carcinogenesis, circadian gene regulation, liver regeneration, apoptosis, and liver-speciﬁc gene regulation. Pharmacol. Rev., 56, 291–330. 49. Cao,D., Bromberg,P.A. and Samet,J.M. (2007) COX-2 expression induced by diesel particles involves chromatin modiﬁcation and degradation of HDAC1. Am. J. Respir. Cell Mol. Biol., 37, 232–239. 50. Subbaramaiah,K. and Dannenberg,A.J. (2007) Cyclooxygenase-2 transcription is regulated by human papillomavirus 16 E6 and E7 oncoproteins: evidence of a corepressor/coactivator exchange. Cancer Res., 67, 3976–3985. 51. Aung,H.T., Schroder,K., Himes,S.R., Brion,K., van Zuylen,W., Trieu,A., Suzuki,H., Hayashizaki,Y., Hume,D.A., Sweet,M.J. et al. (2006) LPS regulates proinﬂammatory gene expression in macrophages by altering histone deacetylase expression. FASEB J., 20, 1315–1327. 52. Lai,P.H., Wang,W.L., Ko,C.Y., Lee,Y.C., Yang,W.M., Shen,T.W., Chang,W.C. and Wang,J.M. (2008) HDAC1/HDAC3 modulates PPARG2 transcription through the sumoylated CEBPD in hepatic lipogenesis. Biochimica. et. biophysica. acta., 1783, 1803–1814. 53. Kim,Y. and Fischer,S.M. (1998) Transcriptional regulation of cyclooxygenase-2 in mouse skin carcinoma cells. Regulatory role of CCAAT/enhancer-binding proteins in the diﬀerential expression of cyclooxygenase-2 in normal and neoplastic tissues. J. Biol. Chem., 273, 27686–27694. 54. Wadleigh,D.J., Reddy,S.T., Kopp,E., Ghosh,S. and Herschman,H.R. (2000) Transcriptional activation of the cyclooxygenase-2 gene in endotoxin-treated RAW 264.7 macrophages. J. Biol. Chem., 275, 6259–6266. 55. Grozinger,C.M. and Schreiber,S.L. (2000) Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. Proc. Natl Acad. Sci. USA, 97, 7835–7840. 56. Kao,H.Y., Verdel,A., Tsai,C.C., Simon,C., Juguilon,H. and Khochbin,S. (2001) Mechanism for nucleocytoplasmic shuttling of histone deacetylase 7. J. Biol. Chem., 276, 47496–47507. 57. Kowenz-Leutz,E. and Leutz,A. (1999) A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes. Mol. Cell, 4, 735–743.