Mechanisms of interkinetic nuclear migration Y Kosodo et al move nuclei, no nuclei move from their original positions (Figure 7Ba). In contrast, when G2- and M-phase nuclei are programmed to migrate in the basal-to-apical direction at 1.0 mm/min (an estimate from experimental results (Figures 1B and 3Ga)), all G1-phase and S-phase nuclei move in the apical-to-basal direction (Figure 7Bb; Supplementary Movie S11). We found remarkable similarities between the nuclear movements predicted by the computational model and those observed in brain slice cultures (Figure 1B). First, apical-to- basal nuclear migration is not linear, but shows back-and-forth 1700 The EMBO Journal VOL 30 | NO 9 | 2011 & 2011 European Molecular Biology Organization