CLINICS 2011;66(10):1757-1763 Thyroid disturbance related to hepatitis C therapy Danilovic DLS et al. Table 1 - The characteristics of the subjects with autoimmune and non-autoimmune interferon-induced thyroiditis and the subjects with no thyroid disorders during interferon-alpha and ribavirin therapy. Time to diagnosis (mo) Age (years) Sex (male/female)a HIV HCV genotype 1 2 3 IFNa Conventional Pegylated Duration of therapy (weeks) Before IFNa: TT3 (ng/dL)b TT4 (mg/dL)c FT4 (ng/dL) TSH (mUI/L)d CDUS*: Heterogeneity (%) Hypoechogenicity (%) Glandular volume (g) Nodules (%) Vascularization (%) I II III Final CDUS* Heterogeneity (%) Hypoechogenicity (%) Glandular volume (g) Nodules (%) Vascularization (%) I II III No thyroid disorder (n = 14) - 44.9¡12.7 8/6 2 8 0 6 5 9 33.6¡14.2 184.7¡35.8 11.9¡2.0 0.9¡0.1 1.8¡0.7 11 (91.7) 2 (16.7) 12.6¡6.8 5 (41.7) 3 (25.0) 2 (16.7) 7 (58.3) 9 (81.8) 2 (18.2) 12.7¡5.7 4 (36.4) 1 (11.1) 6 (66.7) 2 (22.2) Autoimmune IIT (n = 5) 6.7¡3.5 35.6¡10.3 0/5 1 4 0 1 0 5 39.6¡9.8 191.8¡27.7 13.2¡2.5 0.9¡0.1 1,8¡1.4 5 (100) 1 (20.0) 9.3¡2.8 1 (20.0) 0 1 (25.0) 3 (75.0) 2 (100) 1 (50,0) 12.3¡0.7 0 (0) 0 (0) 1 (50.0) 1 (50.0) Non-autoimmune IIT (n = 4) 9.9¡2.2 48.5¡5.7 2/2 1 2 1 1 1 3 42.0¡12.0 141.8¡17.7 8.8¡0.7 0.8¡0.1 3.1¡1.2 3 (75.0) 0 (0) 10.6¡5.1 1 (25.0) 0 1 (33.3) 2 (66.7) 4 (100) 2 (50.0) 9.8¡4.9 2 (50.0) 0 (0) 1 (25.0) 3 (75.0) Reference values: TT3, 40 to 180 ng/dL; TT4, 4.5 to 12 mg/dL; FT4, 0.7 to 1.5 ng/dL; TSH, 0.4 to 4.5 mUI/L (as determined by a fluoroimmunoassay). n, the number of patients; IIT, interferon-induced thyroiditis; IFNa, interferon-alpha; CDUS, thyroid color-flow Doppler ultrasound. *the frequency based on the number of patients, with the CDUS results showing the indicated parameter. ap = 0.045 when comparing the groups with no thyroid disorder and autoimmune IIT. bp = 0.018 when comparing the groups with no thyroid disorder and non-autoimmune IIT. cp = 0.005 when comparing the groups with no thyroid disorder and non-autoimmune IIT. dp = 0.079 when comparing the groups with no thyroid disorder and non-autoimmune IIT. Figure 2 - TSH and FT4 changes during the follow-up of 2 HCV-infected patients with destructive thyroiditis induced by IFNa and ribavirin. Reference values: FT4, 0.7 to 1.5 ng/dL; TSH, 0.4 to 4.5 mUI/L (as determined by a fluoroimmunoassay). 1761