Dovepress 22. Chaitman BR, Pepine CJ, Parker JO, et al. Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: A randomized con- trolled trial. JAMA. 2004;291(3):309–316. 23. US Food and Drug Administration. Available from: http://www.fda. gov/ohrms/dockets/ac/03/briefing/4012B2_01_Action%20Letter.pdf. Accessed April 4, 2007. 24. Penman AD, Eadie J, Herron WJ, Reilly MA, Rush WR, Liu Y. The characterization of the metabolites of ranolazine in man by liquid chromatography mass spectrometry. Rapid Commun Mass Spectrom. 1995;9(14):1418–1430. 25. Herron WJ, Eadie J, Penman AD. Estimation of ranolazine and eleven phase I metabolites in human plasma by liquid chromatography- atmospheric pressure chemical ionisation mass spectrometry with selected-ion monitoring. J Chromatogr A. 1995;712(1):55–60. extended-release ranolazine in stable angina 26. Jerling M, Abdallah H. Effect of renal impairment on multiple-dose pharmacokinetics of extended-release ranolazine. Clin Pharmacol Ther. 2005;78(3):288–297. 27. Arnold SV, Morrow DA, Lei Y, et al. Economic impact of angina after an acute coronary syndrome: Insights from the MERLIN-TIMI 36 trial. Circ Cardiovasc Qual Outcomes. 2009;2(4):344–353. 28. Arnold SV, Morrow DA, Wang K, et al. Effects of ranolazine on disease- specific health status and quality of life among patients with acute coronary syndromes: Results from the MERLIN-TIMI 36 randomized trial. Circ Cardiovasc Qual Outcomes. 2008;1(2):107–115. Vascular Health and Risk Management Publish your work in this journal Vascular Health and Risk Management is an international, peer- reviewed journal of therapeutics and risk management, focusing on concise rapid reporting of clinical studies on the processes involved in the maintenance of vascular health; the monitoring, prevention and treatment of vascular disease and its sequelae; and the involvement of metabolic disorders, particularly diabetes. This journal is indexed on PubMed Central and MedLine. The manuscript management system is completely online and includes a very quick and fair peer-review system, which is all easy to use. Visit http://www.dovepress.com/ testimonials.php to read real quotes from published authors. Submit your manuscript here: http://www.dovepress.com/vascular-health-and-risk-management-journal Dovepress Vascular Health and Risk Management 2011:7 submit your manuscript | www.dovepress.com Dovepress 539