480 necrosis of cultured mesangial cells via P2Z/P2X7 receptors. Am J Physiol 275:F962–F971 95. Coutinho-Silva R, Persechini PM, Da Cunha Bisaggio R, Perfettini J, Torres de Santo AC, Kanellopoulos JM, Mottaly I, Dautry-Varsat A, Ojcius DM (1999) P2Z/P2X7 receptor-depen- dent apoptosis of dendritic cells. Am J Physiol 276:C1139– C1147 96. Ferrari D, Los M, Bauer MK, Vandenabeele P, Wesselborg S, Schulze-Osthoff K (1999) P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death. FEBS Lett 447(1):71–75 97. Ferrari D, Wesselborg S, Bauer MK, Schulze-Osthoff K (1997) Extracellular ATP activates transcription factor NF-κB through the P2Z purinoreceptor by selectively targeting NF-κB p65. J Cell Biol 139(7):1635 –1643 98. Hu Y, Fisette PL, Denlinger LC, Guadarrama AG, Sommer JA, Proctor RA, Bertics PJ (1998) Purinergic receptor modulation of lipopolysaccharide signaling and inducible nitric-oxide synthase expression in RAW 264.7 macrophages. J Biol Chem 273 (42):27170 –27175 99. Von Albertini M, Palmetshofer A, Kaczmarek E, Koziak K, Stroka D, Grey ST, Stuhlmeier KM, Robson SC (1998) Extracellular ATP and ADP activate transcription factor NF-κB and induce endothelial cell apoptosis. Biochem Biophys Res Commun 248(3):822–829 100. De Meyer GR, Van Put DJ, Kockx MM, Van Schil P, Bosmans R, Bult H, Buyssens N, Vanmaele R, Herman AG (1997) Possible mechanisms of collar-induced intimal thickening. Arterioscler Thromb Vasc Biol 17(10):1924 –1930 101. Wang L, Andersson M, Karlsson L, Watson MA, Cousens DJ, Jern S, Erlinge D (2003) Increased mitogenic and decreased contractile P2 receptors in smooth muscle cells by shear stress in human vessels with intact endothelium. Arterioscler Thromb Vasc Biol 23(8):1370 –1376 102. Pulvirenti TJ, Yin JL, Chaufour X, McLachlan C, Hambly BD, Bennett MR, Barden JA (2000) P2X (purinergic) receptor redistribution in rabbit aorta following injury to endothelial cells and cholesterol feeding. J Neurocytol 29(9):623 –631 103. Katoh Y, Periasamy M (1996) Growth and differentiation of smooth muscle cells during vascular development. Trends Cardiovasc Med 6:100 –106 104. Owens GK (1995) Regulation of differentiation of vascular smooth muscle cells. Physiol Rev 75(3):487–517 105. Gabbiani G, Kocher O, Bloom WS, Vandekerckhove J, Weber K (1984) Actin expression in smooth muscle cells of rat aortic intimal thickening, human atheromatous plaque, and cultured rat aortic media. J Clin Invest 73(1):148 –152 106. Kocher O, Gabbiani F, Gabbiani G, Reidy MA, Cokay M, Petters H, Huttner I (1991) Phenotypic features of smooth muscle cells during the evolution of experimental carotid artery intimal thickening: biochemical and morphologic studies. Lab Invest 65(4):459 – 470 107. Schwartz SM, deBlois D, O’Brien ER (1995) The intima: soil for atherosclerosis and restenosis. Circ Res 77(3):445– 465 Purinergic Signalling (2006) 2:471–480 108. Ralevic V, Burnstock G (1991) Effects of purines and pyrimidines on the rat mesenteric arterial bed. Circ Res 69(6):1583–1590 109. Saïag B, Milon D, Allain H, Rault B, Van Den Driessche J (1990) Constriction of the smooth muscle of rat tail and femoral arteries and dog saphenous vein is induced by uridine triphos- phate via `pyrimidinoceptors’, and by adenosine triphosphate via P2X receptors. Blood Vessels 27(6):352–354 110. Andersen HR, Mæng M, Thorwest M, Falk E (1996) Remodel- ing rather than neointimal formation explains luminal narrowing after deep vessel wall injury: insights from a porcine coronary (re)stenosis model. Circulation 93(9):1716 –1724 111. Clowes AW, Clowes MM, Reidy MA (1986) Kinetics of cellular proliferation after arterial injury. III. Endothelial and smooth muscle growth in chronically denuded vessels. Lab Invest 54(3):295–303 112. Haudenschild CC, Schwartz SM (1979) Endothelial regenera- tion. II. Restitution of endothelial continuity. Lab Invest 41 (5):407– 418 113. Shimokawa H, Flavahan NA, Vanhoutte PM (1989) Natural course of the impairment of endothelium-dependent relaxations after balloon endothelium removal in porcine coronary arteries: possible dysfunction of a pertussis toxin-sensitive G protein. Circ Res 65(3):740 –753 114. Weidinger FF, McLenachan JM, Cybulsky MI, Gordon JB, Rennke HG, Hollenberg NK, Fallon JT, Ganz P, Cooke JP (1990) Persistent dysfunction of regenerated endothelium after balloon angioplasty of rabbit iliac artery. Circulation 81(5):1667–1679 115. Valera S, Hussy N, Evans RJ, Adami N, North RA, Surprenant A, Buell G (1994) A new class of ligand gated ion channel defined by P2X receptor for extracellular ATP. Nature 371 (6497):516 –519 116. Nicholas RA, Watt WC, Lazarowski ER, Li Q, Harden TK (1996) Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor. Mol Pharmacol 50(2):224 –229 117. Gordon JL (1986) Extracellular ATP: effects, sources and fate. Biochem J 233(2):309–319 118. Bergfeld GR, Forrester T (1992) Release of ATP from human erythrocytes in response to a brief period of hypoxia and hypercapnia. Cardiovasc Res 26(1):40 –47 119. Bodin P, Burnstock G (1995) Synergistic effect of acute hypoxia on flow-induced release of ATP from cultured endothelial cells. Experientia 51(3):256 –259 120. Viswanathan M, Strömberg C, Seltzer A, Saavedra JM (1992) Balloon angioplasty enhances the expression of angiotensin II AT1 receptors in neointima of rat aorta. J Clin Invest 90 (5):1707–1712 121. Winkles JA, Alberts GF, Brogi E, Libby P (1993) Endothelin-1 and endothelin receptor mRNA expression in normal and atherosclerotic human arteries. Biochem Biophys Res Commun 191(3):1081–1088 122. Majesky MW, Reidy MA, Bowen-Pope DF, Hart CE, Wilcox JN (1990) PDGF ligand and receptor gene expression during repair of arterial injury. J Cell Biol 111:2149 –2158