D704 Nucleic Acids Research, 2012, Vol. 40, Database issue multi-purpose tool-kit at SGD. submitted to Database for Biocuration 2012 virtual issue) is a multifaceted search and retrieval tool that provides access to diverse types of curated and systematic data. Searches can be initiated with a list of genes, a list of GO terms, or results from multiple searches of a variety of data types. At each step, the results can be combined for further analysis. Queries can be customized by modifying predeﬁned templates, or by creating completely new searches via the QueryBuilder. Customized queries facilitate access and retrieval of speciﬁc types of data, without requiring additional programming support at SGD. The search and its results can be saved or downloaded in customizable ﬁle formats. YeastMine can currently query the following data types: GO annotations, chromosomal features, co- ordinates, phenotype annotations, interaction data, orthologs, gene expression and curated literature. We are automating the update of YeastMine from the central SGD databases on a weekly basis. YeastMine will continue to expand with more data types, such as high-throughput chromosome data sets, biochemical pathways and enhanced data presentation. YeastMine was developed using the Intermine environment (25) and is being employed by other model organism databases and the modENCODE project (26) for Drosophila and Caenorhabditis genomic data. YeastMine has many other features such as Web Services and customized widgets that allow enhanced data display and retrieval. Through the integration of new high-throughput data and nextgen sequencing results, implementation of data models and advanced search via YeastMine, and enhancement of data presentation with Gbrowse, SGD has become the modENCODE-like hub for yeast related data (Chan,E.T. and Cherry,J.M. Considerations for creating and annotating the budding yeast Genome Map at SGD: A progress report. submitted to Database for Biocuration 2012 virtual issue). Literature search tools The Textpresso [http://textpresso.yeastgenome.org (27)] search tool is available to search approximately 50 000 papers collected by the SGD project. SGD Textpresso provides access to the full-text and abstracts of papers that have been retrieved for potential curation. Although not all such papers were found to include sufﬁcient yeast-focused information to be included within SGD, these papers may still be generally useful and are thus included in the Textpresso catalog. While full-text search is available from many other sources, Textpresso provides the unique ability to quickly and effectively explore a lit- erature collection using very speciﬁc, complex queries, such as ﬁnding all sentences containing a description of two interacting genes. KEEPING CURRENT WITH CHANGES AT SGD: ANNOUNCEMENTS AND SOCIAL MEDIA News announcements SGD distributes a quarterly newsletter via our web site and direct email. The newsletter focuses on new data and tool development at SGD. We also provide signiﬁcant community news such as future scientiﬁc meetings and new laboratory resources. Blog-style news announcements will be available on the SGD home page providing news noteworthy for the fungal genetics researcher. We are updating our software to allow reporting of news about yeast genomics, notable awards to community members, publication of highly signiﬁcant results and new methods. All posts are also distributed via RSS feed. Social media SGD is now on Facebook and Twitter. Users can ‘Like’ us on Facebook or follow @yeastgenome on Twitter to receive updates about new features, tips on using SGD, real-time meeting updates and other interesting tidbits about yeast. ACKNOWLEDGEMENTS The authors wish to acknowledge Kara Dolinski, Peter Koppstein and Lance Parsons, Princeton University, for help with data preparation and implementation of SPELL at SGD and Kara Dolinski and David Botstein, Princeton University, for encouragement and thoughtful advice. To the Troyanskaya laboratory, Princeton University, for creating the expression data visualization tool, SPELL. Gos Micklem, Julie Sullivan and Richard Smith, University of Cambridge UK, for development and main- tenance of complex data search and display environment, InterMine. Most importantly, the SGD project would not be possible without the continued communication and support of the worldwide community of yeast researchers who provide suggestions for improvement and notice of issues in the data and tools the authors provide. The authors also wish to acknowledge the interactions and discussions with all the members of the Gene Ontology Consortium. The content is solely the responsibility of the authors and does not necessarily represent the ofﬁcial views of the National Human Genome Research Institute or the National Institutes of Health. FUNDING National Human Genome Research Institute of the US National Institutes of Health: Saccharomyces Genome Database project (grant number P41 HG001315); YeastMine development [PI: Gos Micklem, grant number R01 HG004834); Gene Ontology Consortium (PI: Judith Blake, grant number P41 HG002273). Funding for open access charge: NHGRI (grant number P41 HG001315). Conﬂict of interest statement. None declared. REFERENCES 1. Petranovic,D., Tyo,K., Vemuri,G.N. and Nielsen,J. (2010) Prospects of yeast systems biology for human health: integrating lipid, protein and energy metabolism. FEMS Yeast Res., 10, 1046–1059.