18. Chao MP, Jaiswal S, Weissman-Tsukamoto R, Alizadeh AA, Gentles AJ, Volkmer J, et al. Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by cd47. Sci Transl Med 2010; 2:63ra94; PMID:21178137; http://dx.doi.org/ 10.1126/scitranslmed.3001375 19. Chao MP, Jaiswal S, Weissman-Tsukamoto R, Alizadeh AA, Gentles AJ, Volkmer J, et al. Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47. Sci Transl Med 2010; 2:63ra94; PMID:21178137; http://dx.doi. org/10.1126/scitranslmed.3001375 20. Majeti R, Chao MP, Alizadeh AA, Pang WW, Jaiswal S, Gibbs KD, Jr., et al. Cd47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell 2009; 138:286-99; PMID:19632179; http://dx.doi.org/10.1016/j.cell.2009. 05.045 21. Chan KS, Espinosa I, Chao M, Wong D, Ailles L, Diehn M, et al. Identification, molecular characteriza- tion, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Proc Natl Acad Sci USA 2009; 106:14016-21; PMID:19666525; http://dx.doi.org/10.1073/pnas.0906549106 22. Chao MP, Alizadeh AA, Tang C, Myklebust JH, Varghese B, Gill S, et al. Anti-cd47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-hodgkin lymphoma. Cell 2010; 142:699-713; PMID:20813259; http://dx.doi.org/10.1016/j.cell.2010. 07.044 23. Nimmerjahn F, Ravetch JV. Antibodies, fc receptors and cancer. Curr Opin Immunol 2007; 19:239-45; PMID:17291742; http://dx.doi.org/10.1016/j.coi.2007. 01.005 24. Chao MP, Alizadeh AA, Tang C, Jan M, Weissman- Tsukamoto R, Zhao F, et al Therapeutic antibody targeting of cd47 eliminates human acute lymphoblastic leukemia. Cancer Res 2010. 25. Kikuchi Y, Uno S, Kinoshita Y, Yoshimura Y, Iida S, Wakahara Y, et al. Apoptosis inducing bivalent single- chain antibody fragments against cd47 showed anti- tumor potency for multiple myeloma. Leuk Res 2005; 29:445-50; PMID:15725479; http://dx.doi.org/10. 1016/j.leukres.2004.09.005 26. Kikuchi Y, Uno S, Yoshimura Y, Otabe K, Iida S, Oheda M, et al. A bivalent single-chain fv fragment against cd47 induces apoptosis for leukemic cells. Biochem Biophys Res Commun 2004; 315:912-8; PMID:14985099; http://dx.doi.org/10.1016/j.bbrc.2004.01.128 27. Mateo V, Lagneaux L, Bron D, Biron G, Armant M, Delespesse G, et al. Cd47 ligation induces caspase- independent cell death in chronic lymphocytic leuke- mia. Nat Med 1999; 5:1277-84; PMID:10545994; http://dx.doi.org/10.1038/15233 28. Uno S, Kinoshita Y, Azuma Y, Tsunenari T, Yoshimura Y, Iida S, et al. Antitumor activity of a monoclonal anti- body against cd47 in xenograft models of human leuke- mia. Oncol Rep 2007; 17:1189-94; PMID:17390064 29. Reinhold MI, Lindberg FP, Plas D, Reynolds S, Peters MG, Brown EJ. In vivo expression of alternatively spliced forms of integrin-associated protein (cd47). J Cell Sci 1995; 108:3419-25; PMID:8586654 30. Subramanian S, Parthasarathy R, Sen S, Boder ET, Discher DE. Species- and cell type-specific interactions between cd47 and human sirpalpha. Blood 2006; 107:2548-56; PMID:16291597; http://dx.doi.org/10. 1182/blood-2005-04-1463 31. Heidenreich S, Gong JH, Schmidt A, Nain M, Gemsa D. Macrophage activation by granulocyte/macrophage colony-stimulating factor. Priming for enhanced release of tumor necrosis factor-alpha and prostaglandin e2. J Immunol 1989; 143:1198-205; PMID:2473121 32. Heal R, McGivan J. Induction of calreticulin expression in response to amino acid deprivation in chinese hamster ovary cells. Biochem J 1998; 329:389-94; PMID:9425124 33. Jethmalani SM, Henle KJ, Gazitt Y, Walker PD, Wang SY. Intracellular distribution of heat-induced stress glycoproteins. J Cell Biochem 1997; 66:98-111; PMID: 9215532; http://dx.doi.org/10.1002/(SICI)1097-4644 (19970701)66:1,98::AID-JCB11.3.0.CO;2-9 34. Armeanu-Ebinger S, Bonin M, Habig K, Poremba C, Koscielniak E, Godzinski J, et al. Differential expression of invasion promoting genes in childhood rhabdomyo- sarcoma. Int J Oncol 2011; 38:993-1000; PMID: 21271214; http://dx.doi.org/10.3892/ijo.2011.921 35. Fredriksson K, Tjader I, Keller P, Petrovic N, Ahlman B, Scheele C, et al. Dysregulation of mitochondrial dynamics and the muscle transcriptome in icu patients suffering from sepsis induced multiple organ failure. PLoS ONE 2008; 3:e3686; PMID:18997871; http:// dx.doi.org/10.1371/journal.pone.0003686 286 OncoImmunology Volume 1 Issue 3