4 tumors. Being feasible via open and minimally invasive approaches, partial adrenalectomy may also be performed for those with a normal contralateral gland. Our patient, although having excluded a relevant family history, harbored most of the classical features of VHL dis- ease. He was classiﬁed as having Type 2B disease (pheochro- mocytoma, renal cell cancer, and pancreatic cyst). He had synchronously detected bilateral renal and adrenal lesions. Therefore, he was scheduled for a staged surgical treatment. During the ﬁrst stage, the right adrenal gland, which was found to be completely replaced by pheochromocytoma, was removed. At the second stage, a total of 5 pheochromocy- tomas were excised while preserving an adequate amount of adrenocortical tissue. He did not require any hormonal substitution postoperatively and pheochromocytoma did not recur in a follow-up period of 30 months. 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