RESEARCH Methods South Carolina, like many other cities and states that have historically had few Latinos, has experienced recent surges in immigration and now has small informal enclaves and social structures. Many Latinos in these new communities may lack documentation for US residency. Consequently, our sampling design took into account the fact that many probability-based sampling designs (e.g., random-digit dialing telephone survey, mail survey from a published list of addresses) would not adequately access this hard-to-reach population. Adult (>18 years of age) Latinos attending 2 clinics in the greater Charleston, South Carolina, area that serve a primarily Latino population were approached for participation in a face-to-face, struc- tured, confidential interview in which no names were recorded. This Latino population was employed primarily in agriculture. Eligible persons included both those seeking care as well as those accompanying patients since the goal was to collect data from Latino adults regarding health behavior that was not necessarily linked to a current illness. Persons in the waiting rooms of the clinic were approached by an interviewer, who was introduced to the prospective respon- dent by clinic personnel. If persons did not consider them- selves to be Latino, they were not included in the study. Data were collected in July and August 2004. The study was approved by the Medical University of South Carolina Institutional Review Board. Instrument Previously used and validated surveys designed for use with Latino populations were accessed from the scientific literature and were consulted for question wording rele- vant to the present study’s aims. An instrument was creat- ed in English, pretested initially in English for flow and comprehension, and following modifications was then translated into Spanish. Once in Spanish, the instrument was put through 2 levels of pretests. The first pretest was with medical center personnel who were fluent with Spanish and dealt with Latino populations. Following modifications from the first pretest, the second pretest was conducted with Latino persons seen at a clinic different from the ones used in the study to provide pretest experi- ence with the instrument with a similar population. After the second pretest, the instrument was translated back into English so that the wording of the questions could be checked for consistency in both English and Spanish. Two trained bilingual interviewers administered the survey in a structured format in the participant’s preferred language (Spanish or English) and reinforced to the potential respondents the anonymous nature of the survey. Variables The study focused on 3 general sets of information. First, questions were included that assessed acquiring antimicrobial drugs without a prescription while outside the United States and corresponding self-medication. These questions were asked to get an idea of health behav- ior in their home culture and society. In addition, we asked whether the respondents believed that antimicrobial drugs should be available in the United States without a prescrip- tion. Second, questions were included that provided an assessment of the importation of nonprescription antimi- crobial drugs into the United States and the context and circumstances related to this behavior. Third, a set of ques- tions was included that assessed acquisition of nonpre- scribed antimicrobial drugs within the United States. We were specifically interested in the scope of acquisition of nonprescribed antimicrobial drugs from bodegas, pharma- cias, or other stores since this behavior had been suggest- ed in a study in New York City (17). For both importing nonprescribed antimicrobial drugs and acquiring them within the United States, a series of questions was asked, based on the pretest information, to gain an understanding of why the respondents would engage in these practices. Analysis Initially, descriptive statistics were computed to gain an understanding of the extent of the acquisition and importa- tion of nonprescribed antimicrobial drugs. We also com- puted chi-square values to examine bivariate relationships between importation of nonprescribed antimicrobial drugs and acquisition of nonprescribed antimicrobial drugs in the United States by health beliefs and behavior in the home country, access to care in the United States, and demo- graphic characteristics. Finally, a stepwise logistic regres- sion model was computed on the dependent variable of acquisition of nonprescribed antimicrobial drugs with the same set of variables (acquired antimicrobial drugs with- out a prescription outside the United States, believe antimicrobial drugs should be available in the United States without a prescription, health insurance, age, sex, education, time in United States, country of birth, health status) to determine the best predictors of this behavior. Because no one born in the United States had acquired nonprescribed antimicrobial drugs in the United States, the category variable of country of birth was not used as a pre- dictor of acquiring nonprescribed antimicrobial drugs. Instead, country of birth was coded for inclusion in the regression as 1) born in Mexico or 2) born elsewhere. Results A total of 277 adults were approached for participation. Four persons who were initially approached indicated that they did not consider themselves to be Latino. Of the 884 Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 11, No. 6, June 2005