structural community. biologists and the general biological SUPPLEMENTARY DATA Supplementary Data are available at NAR Online. ACKNOWLEDGEMENTS The PSI-MR would like to thank the PSI centers, the PSI Structural Genomics Knowledgebase and the NIGMS staﬀ for their continued support and input in all aspects of this project. Thanks also to the Dana Farber Harvard Cancer Center (DF/HCC) DNA Resource Core for their support and distribution of the PSI collection. The authors would like to thank the Harvard Medical School Oﬃce of Technology Development (OTD), the Harvard University Oﬃce of General Counsel and the Arizona State University’s Oﬃce of Research and Sponsored Projects for their guidance, support and legal advice. FUNDING National Institute of General Medical Sciences (grant number U01 GM079617); National Cancer Institute (grant number 5P30 CA06516-06); National Institute of Allergy and Infectious Disease (grant number HHSN2332200400053C/N01-A1-40053); and Virginia G. 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