178 14. van Damme PA, Mooren RE. Differentiation of multiple giant- cell lesions, Noonan-like syndrome, and (occult) hyperparathy- roidism: case report and review of the literature. Int J Oral Maxillofac Surg. 1994;23:32–6. doi:10.1016/S0901-5027(05) 80323-6. 15. Stolovitzky JP, Waldron CA, McConnel FMS. Giant cell lesions of the maxilla and paranasal sinuses. Head Neck. 1994;16:143–8. doi:10.1002/hed.2880160207. 16. Terry BC, Jacoway JR. Management of central giant cell lesions: an alternative to surgical therapy. Oral Maxillofac Surg Clin North Am. 1994;6:579–600. 17. de Lange J, van den Akker HP, Veldhuijzen van Zanten GO, et al. Calcitonin therapy in central giant cell granuloma of the jaw: a randomized double-blind placebo-controlled study. Int J Oral Maxillofac Surg. 2006;35:791–5. doi:10.1016/j.ijom.2006.03.030. 18. de Lange J, van den Akker HP, van den Berg H, et al. Limited regression of central giant cell granuloma by interferon alpha after failed calcitonin therapy: a report of 2 cases. Int J Oral Maxillofac Surg. 2006;35:865–9. doi:10.1016/j.ijom.2006.02.011. 19. Kaban LB, Troulis MJ, Ebb D, et al. Antiangiogenic therapy with interferon alpha for giant cell lesions of the jaws. J Oral Max- illofac Surg. 2002;60:1103–11. doi:10.1053/joms.2002.34975. 20. Bernick S. Central giant cell tumors of the jaws. J Oral Surg. 1948;6:324. 21. Jaffe H. Giant cell reparative granuloma, traumatic bone cyst, and ﬁbrous (ﬁbro-osseous) dysplasia of the jaw bones. Oral Surg Oral Med Oral Pathol. 1953;6:159–75. doi:10.1016/0030-4220(53) 90151-0. 22. Shklar G, Meyer I. A giant-cell tumor of the maxilla in an area of osteitis deformans (Paget’s disease of bone). Oral Surg Oral Med Oral Pathol. 1958;11:835–42. doi:10.1016/0030-4220(58) 90198-1. 23. Austin L, Dahlin D, Royer R. Giant-cell reparative granuloma and related conditions affecting the jawbones. Oral Surg Oral Med Oral Pathol. 1959;12:1285–95. doi:10.1016/0030-4220(59) 90215-4. 24. Abrams B, Shear M. A histological comparison of the giant cells in central giant cell granuloma of the jaws and the giant cell tumor of long bone. J Oral Pathol. 1974;3:217–23. doi:10.1111/ j.1600-0714.1974.tb01714.x. 25. Auclair PL, Kratochvil FJ, Slater LJ, et al. A clinical and histo- morphologic comparison of the central giant cell granuloma and giant cell tumor. Oral Surg Oral Med Oral Pathol. 1988;66:197– 208. doi:10.1016/0030-4220(88)90094-1. 26. Cohen MM Jr, Gorlin RJ. Noonan-like/multiple giant cell lesion syndrome. Am J Med Genet. 1991;40:159–66. doi:10.1002/ ajmg.1320400208. 27. Regezi JA, Zarbo RJ, Lloyd RV. Muramidase, alpha-1 antitryp- sin, alpha-1 antichymotrypsin, and S-100 protein immunoreac- tivity in giant cell lesions. Cancer. 1987;59:64–8. doi:10.1002/ 1097-0142(19870101)59:1\64::AID-CNCR2820590116[3.0. CO;2-Q. 28. O’Malley M, Pogrel MA, Stewart JC, et al. Central giant cell granulomas of the jaws: phenotype and proliferation-associated markers. J Oral Pathol Med. 1997;26:159–63. doi:10.1111/j.1600- 0714.1997.tb00451.x. Head and Neck Pathol (2009) 3:174–178 29. Tobon-Arroyave SI, Franco-Gonzalez LM, Isaza-Guzman DM, et al. Immunohistochemical expression of RANK, GRalpha and CTR in central giant cell granuloma of the jaws. Oral Oncol. 2005;41:480–8. doi:10.1016/j.oraloncology.2004.11.006. 30. Wang C, Song Y, Peng B, et al. Expression of c-Src and com- parison of cytologic features in cherubism, central giant cell granuloma and giant cell tumors. Oncol Rep. 2006;15:589–94. 31. Lietman SA, Prescott NL, Hicks DG, et al. SH3BP2 is rarely mutated in exon 9 in giant cell lesions outside cherubism. Clin Orthop Relat Res. 2007;459:22–7. doi:10.1097/BLO.0b013e3 1804b4131. 32. Lee CH, Espinosa I, Jensen KC, et al. Gene expression proﬁling identiﬁes p63 as a diagnostic marker for giant cell tumor of the bone. Mod Pathol. 2008;21:531–9. doi:10.1038/modpathol. 3801023. 33. Dickson BC, Li SQ, Wunder JS, et al. Giant cell tumor of bone express p63. Mod Pathol. 2008;21:369–75. doi:10.1038/ modpathol.2008.29. 34. Miloro M, Quinn PD. Synchronous central giant cell lesions of the jaws: report of a case and review of the literature. J Oral Maxillofac Surg. 1995;53:1350–5. doi:10.1016/0278-2391(95)90600-2. 35. Martins WD, de Oliveira Ribas M, Braosi AP, et al. Multiple giant cell lesions of the maxillofacial skeleton. J Oral Maxillofac Surg. 2007;65:1250–3. doi:10.1016/j.joms.2005.10.046. 36. Cassatly MG, Greenberg AM, Kopp WK. Bilateral giant cell granulomata of the mandible: report of a case. J Am Dent Assoc. 1988;117:731–3. 37. Weldon L, Cozzi G. Multiple giant cell lesions of the jaws. J Oral Maxillofac Surg. 1982;40:520–2. doi:10.1016/0278-2391 (82)90016-7. 38. Curtis NJ, Walker DM. A case of aggressive multiple metach- ronous central giant cell granulomas of the jaws: differential diagnosis and management options. Int J Oral Maxillofac Surg. 2005;34:806–8. doi:10.1016/j.ijom.2005.01.010. 39. Davis JP, Archer DJ, Fisher C, et al. Multiple recurrent giant cell lesions associated with high circulating levels of parathyroid hormone-related peptide in a young adult. Br J Oral Maxillofac Surg. 1991;29:102–5. doi:10.1016/0266-4356(91)90092-J. 40. Smith PG, Marrogi AJ, Delﬁno JJ. Multifocal central giant cell lesions of the maxillofacial skeleton: a case report. J Oral Max- illofac Surg. 1990;48:300–5. doi:10.1016/0278-2391(90)90398-L. 41. Struthers PJ, Shear M. Aneurysmal bone cyst of the jaws. (II). Pathogenesis. Int J Oral Surg. 1984;13:92–100. doi:10.1016/ S0300-9785(84)80078-2. 42. Levy W, Miller A, Bonakdarpour A, et al. Aneurysmal bone cyst secondary to other osseous lesions: report of 57 cases. Am J Clin Pathol. 1975;63:1–8. 43. Davis GB, Tideman H. Multiple recurrent central giant cell granulomas of the jaws. J Maxillofac Surg. 1977;5:127–9. doi:10.1016/S0301-0503(77)80089-1. 44. Loukota RA. Metachronous and recurrent central giant cell granulomas: a case report. Br J Oral Maxillofac Surg. 1991;29: 48–50. doi:10.1016/0266-4356(91)90175-5. 45. Wise AJ, Bridbord JW. Giant cell granuloma of the facial bones. Ann Plast Surg. 1993;30:564–8. doi:10.1097/00000637-19930 6000-00019.