164 Yimam et al. as Univestin. While this does not detract from the results of the study, the editors feel that this information should be listed in the conflict of interest section of the manuscript. The authors alone are responsible for the content and writing of this paper. REFERENCES Adedapo AA, Sofidiya MO, Masika PJ, Afolayan AJ. Anti-inflammatory and analgesic activi- ties of the aqueous extract of Acacia karroo stem bark in experimental animals. Basic Clin Pharmacol Toxicol. 2008;103:397–400. Altavilla D, Squadrito F, Bitto A, Polito F, Burnett BP, Di Stefano V, Minutoli L. Flavocoxid, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, blunts pro-inflammatory phenotype activation in endotoxin-stimulated macrophages. Br J Pharmacol. 2009;157:1410–1418. Azim MK, Perveen H, Mesaik MA, Simjee SU. Antinociceptive activity of natural honey in thermal-nociception models in mice. Phytother Res. 2007;21:194–197. Badilla B, Mora G, Lapa AJ, Emim JA. Anti-inflammatory activity of Urera baccifera (Ur- ticaceae) in Sprague-Dawley rats. Rev Biol Trop. 1999;47:365–371. Burnett BP, Jia Q, Zhao Y, Levy RM. A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation. J Med Food. 2007;10:442–451. Chou TC, Chang LP, Li CY, Wong CS, Yang SP. The antiinflammatory and analgesic effects of baicalin in carrageenan-evoked thermal hyperalgesia. Anesth Analg. 2003;97:1724–1729. Collier HO, Dinneen LC, Johnson CA, Schneider C. The abdominal constriction response and its suppression by analgesic drugs in the mouse. Br J Pharmacol Chemother. 1968;32:295–310. Dongmo AB, Nguelefack T, Lacaille-Dubois MA. Antinociceptive and anti-inflammatory activ- ities of Acacia pennata wild (Mimosaceae). J Ethnopharmacol. 2005;98:201–206. dos Santos MD, Almeida MC, Lopes NP, de Souza GE. Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid. Biol Pharm Bull. 2006;29:2236–2240. Dubuisson D, Dennis SG. The formalin test: a quantitative study of the analgesic effects of mor- phine, meperidine, and brain stem stimulation in rats and cats. Pain. 1977;4:161–174. Ferreira SH, Lorenzetti BB, Correa FM. Central and peripheral antialgesic action of aspirin-like drugs. Eur J Pharmacol. 1978;53:39–48. Flower RJ. Drugs which inhibit prostaglandin biosynthesis. Pharmacol Rev. 1974;26:33–67. Gamache DA, Povlishock JT, Ellis EF. Carrageenan-induced brain inflammation. Characteriza- tion of the model. J Neurosurg. 1986;65:679–685. Guay J, Bateman K, Gordon R, Mancini J, Riendeau D. Carrageenan-induced paw edema in rat elicits a predominant prostaglandin E2 (PGE2) response in the central nervous system associ- ated with the induction of microsomal PGE2 synthase-1. J Biol Chem. 2004;279:24866–24872. Huang WH, Lee AR, Yang CH. Antioxidative and anti-inflammatory activities of poly- hydroxyflavonoids of Scutellaria baicalensis GEORGI. Biosci Biotechnol Biochem. 2006;70:2371–2380. Isbrucker RA, Burdock GA. Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharma- cology and toxicology of glycyrrhizin. Regul Toxicol Pharmacol. 2006;46:167–192. Jia Q. USA Patent #7,514,469. 2009. Kanegusuku M, Sbors D, Bastos ES, de Souza MM, Cechinel-Filho V, Yunes RA, Delle Monache F, Niero R. Phytochemical and analgesic activity of extract, fractions and a 19- hydroxyursane-type triterpenoid obtained from Rubus rosaefolius (Rosaceae). Biol Pharm Bull. 2007;30:999–1002. Meotti FC, Luiz AP, Pizzolatti MG, Kassuya CA, Calixto JB, Santos AR. Analysis of the antinoci- ceptive effect of the flavonoid myricitrin: evidence for a role of the L-arginine-nitric oxide and protein kinase C pathways. J Pharmacol Exp Ther. 2006;316:789–796.