Herpes Simplex Virus 2 Infection during Pregnancy Table 1. Comparison of Maternal Demographic Data Herpes virus 2 antibody-positive Maternal age (yrs) 31.6±4.6 <20 0 (0) 21-24 4 (4.7) 25-29 27 (31.7) 30-34 30 (35.2) 35-40 20 (23.5) ≥41 4 (4.7) Gestational age (wks) 38.9±1.4 Primipara-to-multipara ratio 56 : 29 Gender (M : F) 1 : 1 Birth weight (kg) 3.2±0.4 Values are presented as the mean±SD or number (%). Table 2. Comparison of Seropositivity Rubella IgM Rubella IgG Varicella antibody-positive HBsAg-positive HBsAb-positive HB, hepatitis B. Values are presented as a number (%). Herpes virus 2 antibody-positive 0 78 (91.8) 78 (91.8) 6 (7.1) 64 (75.3) Control 30.4±4.2 5 (1.2) 24 (5.7) 162 (39.0) 149 (35.9) 68 (16.3) 7 (1.6) 39.2±1.1 296 : 119 1 : 1 3.2±0.3 Control 0 369 (88.9) 386 (93.0) 21 (5.1) 308 (74.2) p value 0.014 0.076 0.317 0.998 0.492 p value 0.437 0.648 0.434 0.892 group and 21 of 415 gravidas (5.1%) in the healthy control group were HBsAg-positive. Sixty-four gravidas (75.3%) in the HSV2 positive group and 308 gravidas (74.2%) in the healthy control group were HBsAb-positive. There were no significant differences in rubella and varicella antibody ti- ters, as well as the HBsAg-positive, and HBsAb-positive rates between the two groups of gravidas (Table 2). Comparison of sexually transmitted pathogens No gravidas were HIV-positive or VDRL-positive in either group. One gravida (1.2%) in the HSV2 positive group and three gravidas (0.7%) in the healthy control group had geni- tal condyloma infections. Four of 14 gravidas (28.6%) in the HSV2 positive group and 13 of 35 gravidas (37.1%) in the healthy control group had HPV infections. There were no significant differences in condyloma and HPV infections between the two groups of gravidas. Twelve of 17 gravidas (70.6%) in the HSV2 positive group and 23 of 49 gravidas (46.93%) in the control group had positive sexually trans- mitted disease screens (Table 3). There was a significant difference in sexually transmitted disease screening be- tween the two groups (p<0.05). Comparison of obstetric complications Thirty-three of 85 gravidas (38.8%) in the HSV2 positive group and 123 of 415 gravidas (29.6%) in the healthy con- trol group had a history of abortions. There was a signifi- cant difference in the abortion rates between the 2 groups (p<0.05). Two of 85 gravidas (2.3%) in the HSV2 positive group and 15 of 415 gravidas (3.6%) in the healthy control group had preterm labor. Eighteen gravidas (21.2%) in the HSV2 positive group and 73 gravidas (17.6%) in the healthy control group had premature rupture of membranes. Seven gravidas (8.2%) in the HSV2 positive group and 26 gravi- das (6.2%) in the healthy control group had preterm deliv- eries. Fourteen of 85 gravidas (16.4%) in the HSV2 posi- tive group and 75 of 415 gravidas (18.0%) in the healthy control group were diagnosed with intrauterine growth re- tardation. Three of 85 newborns (3.5%) in the HSV2 posi- tive group and 6 of 415 neonates (1.4%) in the healthy con- trol group were admitted to the neonatal ICU (Table 4). There were no significant differences in the rates of preterm labor, premature rupture of membranes, preterm delivery, intrauterine growth retardation, and neonatal ICU admis- sion between the two groups. DISCUSSION This is the first study to attempt to determine the prevalence Yonsei Med J http://www.eymj.org Volume 53 Number 2 March 2012 403