more documentation, see MPD ‘BioDBcore Statement’ (S19). Information for developers is also available (For Developers: S20). FUTURE MPD DIRECTIONS AND AN INVITATION TO INVESTIGATORS MPD will continue implementing useful linkages to other databases and populating the database with phenotype, genotype and gene expression data. We continue to reﬁne MPD data classiﬁcations with relevant ontologies, optimizing search and navigation functionality as well as facilitating data integration within MPD and across data- bases. We are in the process of loading Sanger SNPs, indels and structural variants derived from whole-genome sequencing of 17 inbred mouse strains (7,8), and we will take advantage of the availability of the RNA-seq data being released by Sanger on this set of strains. RNA-seq data will complement existing MPD data and will enable queries to determine expression levels of different alleles of a gene and to detect post-transcriptional mutations or other genetic alterations. Many phenotypic domains are currently represented in MPD; however, the acquisition of new data is open-ended with the goal of collecting data on a broader scope (and in some cases to a deeper level for more granular phenotypes or endophenotypes) as well as collecting data generated from new, more sophisticated phenotyping technologies. Although we have added a signiﬁcant number of pheno- types since our last update (Table 2), we will continue working toward accessioning more data for inbred strains and other strain types as well as for new panels such as the Collaborative Cross (34–36). We would like to take this opportunity to make an appeal for clinically relevant data in toxicology and speciﬁc disease areas: cancer, digestive diseases, kidney disease, neurological dis- orders, drug addiction and infectious diseases. To expand the scope and maximize the utility of MPD, members of the global scientiﬁc community are invited to contribute their strain survey data or join us in a coordinated effort to seek funding that will support these studies. This spirit of collaboration has shaped and will continue to guide the future growth and development of MPD. Researchers interested in contributing data or in collaborating on new phenotyping projects should contact us at phenome@jax.org. Data submission guidelines are access- ible through the MPD homepage (Contributing Data: S21). Nucleic Acids Research, 2012, Vol. 40, Database issue D893 CITING MPD AND USER SUPPORT For general citation of MPD, this NAR article may be used. In addition, the following citation format is preferred when referring to MPD projects or using MPD data sets. Investigator(s) name (year project posted) Project title. MPD project symbol (e.g. Smith1) and/or accession number (MPD:XXX). Mouse Phenome Database Website, The Jackson Laboratory, Bar Harbor, ME, USA. (URL: http:// phenome.jax.org), date of download or access. For more information visit our website and search on ‘citing’. MPD provides user support through online documen- tation (S17, S18) and via email (phenome@jax.org). We welcome user input and suggestions, which can be submitted anonymously through our Suggestion Box links at the bottom of most MPD webpages. SUPPLEMENTARY DATA Supplementary Data are available at NAR Supplementary Table 1. Online: ACKNOWLEDGEMENTS We thank participating investigators for contributing their data for worldwide access (S4, S5). GWAS-EMMA analyses are provided through a collaboration with the UCLA ZarLab (Eleazar Eskin); in particular, we thank Emrah Kostem for his diligence and efforts to make this possible. We appreciate the critical review of this manu- script by Mary Dolan, Susan M. Bello and Alicia Valenzuela. FUNDING The Jackson Laboratory and National Institutes of Health (grant numbers HG003057, HL66611, AG025707, AG038070, MH071984, DA028420). MPD houses and maintains data from research projects sup- ported by over 80 funding agencies and research founda- tions worldwide (Funding: S22). Funding for open access charge: National Institutes of Health (DA028420). Conﬂict of interest statement. None declared. Figure 3. Continued results (middle-left panel) is one place where users can take advantage of our new ‘workbook’ feature for paring down and gathering candidate genes. Lists are provided a new window, and checkboxes are supplied to exclude (or include) genes in an updated list. At any time, users may opt to generate a separate clean list of gene symbols or various accession ID options to copy/paste into batch query forms of other bioinformatics resources. Note 2: The gene directory box shown in the bottom–right panel is a hub for information and linkouts to other resources (additional features are added as needed). We provide one-click deployment to SNP tools, ﬁnding MPD phenotype measurements that correlate, and information about available gene expression probesets, including tools to compare probesets between gene expression projects and to compare female and male for a single probeset within a project. Users will arrive at a gene directory page from any gene link on the MPD website, from gene searches and from general searches that turn up genes. For Developers wanting to link to our gene directory page, use this URL template: http://phenome.jax. org/db/qp?rtn=markers/details&reqsym=Abcd1, where Abcd1 is gene symbol (For Developers: S22).