Jae Mann Song, et al. Table 5. Summary of Meta-Analysis Results by Diagnostic Method for Prostate Cancer DMieatghnoodsis DF Estimate of d̅ Variance of d̅ 95I%nteCrvoanlfiodfend̅ce Q Statistics PSA4 11 0.8517 0.0087 0.6694 1.0340 16.1136 PSA10 10 1.0996 0.0062 0.9459 1.2534 13.4319 DRE 12 0.8398 0.0039 0.7169 0.9627 50.1208 TRUS 12 0.8002 0.0043 0.6714 0.9289 49.7032 PSA4, Prostate Specific Antigen (greater than 4 ng/mL) PSA10, Prostate Specific Antigen (greater than 10 ng/mL) DRE, Digital Rectal Examination; TRUS, Transrectal Ultrasonography. DF, Degree of Freedom. p value 0.1370 0.2005 <0.001 <0.001 Table 6-1. Outcomes of Combination Testing of PSA4, DRE and TRUS for Detection of Prostate Cancer by the Study (N=5) Test PSA4 - + - - + + - + DRE - - + - + - + + Total Study TRUS - - - + - + + + Kim TH et al. (1994) 0/42 2/55 0/4 0/6 1/6 0/3 3/3 12/14 18/133 Park HK et al. (1994) 2/15 1/33 0/3 0/7 2/7 2/6 0/4 12/18 19/93 Park SW et al. (1995) 0/1 0/31 0/2 0/6 2/8 3/15 0/1 10/14 15/78 Seo WK et al. (1996) 3/42 4/66 0/6 0/8 6/15 6/33 1/3 20/28 40/201 Chang HJ et al. (1999) 0/0 0/14 1/8 0/0 12/31 5/38 2/15 15/27 35/133 Total 5/ 100 7/ 199 1/ 23 0/ 27 23/ 67 16/ 95 6/ 26 69/ 101 127/ 638 (5.0) (3.5) (4.3) (0.0) (34.3) (16.8) (23.1) (68.3) (19.9) Data: No. of cancer patients in biopsy result/No. of patients tested by diagnostic triad (%). PSA4, Prostate Specific Antigen (greater than 4 ng/mL) DRE, Digital Rectal Examination; TRUS, Transrectal Ultrasonography. -: Negative result (normal) in the diagnostic test, +: Positive result (abnormal) in the diagnostic test. Table 6-2. Outcomes of Combination Testing of PSA10, DRE and TRUS for Detection of Prostate Cancer by the Study (N=5) Test PSA10 - + - - + + - + DRE - - + - + - + + Total Study TRUS - - - + - + + + Kim TH et al. (1994) 0/71 2/26 0/7 0/6 1/3 0/3 3/5 12/12 18/133 Park HK et al. (1994) 3/28 0/20 0/6 0/10 2/4 2/3 1/11 11/11 19/93 Choi JH et al. (1996) 1/12 1/5 0/4 0/8 0/4 2/13 0/5 7/13 11/64 Seo WK et al. (1996) 5/69 2/39 0/9 2/28 6/12 4/13 1/6 20/25 40/201 Chang HJ et al. (1999) 0/10 0/4 2/22 1/23 11/17 4/15 4/21 13/21 35/133 Total 9/ 190 5/ 94 2/ 48 3/ 75 20/ 40 12/ 47 9/ 48 63/ 82 123/ 624 (4.7) (5.3) (4.2) (4.0) (50.0) (25.5) (18.8) (76.8) (19.7) Data: No. of cancer patients in biopsy result/No. of patients tested by diagnostic triad (%). PSA10, Prostate Specific Antigen (greater than 10 ng/mL) DRE, Digital Rectal Examination; TRUS, Transrectal Ultrasonography. -: Negative result (normal) in the diagnostic test, +: Positive result (abnormal) in the diagnostic test. Yonsei Med J Vol. 46, No. 3, 2005