CLINICS 2010;65(5):531-7 Table 3 - Respiratory and oxygenation data. Sevoflurane MAC and hemodynamics in pigs Otsuki DA et al. Group 0.5 MAC 1.0 MAC 1.5 MAC RR (mpm) Sevo A 19 (2) 19 (2) 19 (2) Sevocris 20 (2) 20 (2) 20 (2) P Peak (cmH2O) Sevo A 22 (3) 21 (3) 21 (3) Sevocris 20 (4) 20 (3) 20 (3) P Plato (cmH2O) Sevo A 20 (3) 20 (3) 20 (3) Sevocris 19 (3) 19 (3) 19 (3) ComplDyn (mL/cmH2O) Sevo A 23 (5) * 26 (6) 27 (6) † Sevocris 24 (5) 26 (4) 26 (5) Vt (mL) Sevo A 339 (22) * 359 (29) 370 (39) * † Sevocris 335 (22) * 350 (28) 362 (22) * † EtCO2 (mmHg) Sevo A 44 (2) 43 (2) 41 (2) * † Sevocris 44 (2) 43 (4) 41 (4) † pH art Sevo A 7.454 (0.024) 7.463 (0.026) 7.477 (0.025) Sevocris 7.464 (0.024) 7.472 (0.041) 7.459 (0.060) PaCO2 (mmHg) Sevo A 45 (2) 44 (3) 40 (5) Sevocris 44 (2) 43 (5) 42 (8) PaO2 (mmHg) Sevo A 174 (36) 166 (40) 160 (43) Sevocris 181 (20) 162 (27) 157 (33) SaO2 (%) Sevo A 99.2 (0.5) 99.0 (0.5) 98.9 (0.9) Sevocris 99.4 (0.2) 99.1 (0.4) 99.0 (0.7) † Lactate (mmol/L) Sevo A 1.1 (0.3) 1.1 (0.3) 1.5 (1.0) Sevocris 1.0 (0.2) 1.1 (0.3) 1.3 (0.3) PvO2 (mmHg) Sevo A 47 (5) 45 (6) 36 (5) * † Sevocris 50 (3) * 45 (5) 38 (6) * † SvO2 (%) Sevo A 77.3 (7.3) 76.1 (7.3) 62.5 (14.7) * † Sevocris 81.6 (3.9) 76.0 (6.2) 64.7 (12.4) * † DO2I (mL/min/m2) Sevo A 825 (172) * 606 (56) 434 (96) * † Sevocris 880 (66) * 671 (176) 498 (156) * † VO2I (mL/min/m2) Sevo A 173 (19) 142 (33) 143 (31) Sevocris 175 (22) 162 (32) 162 (12) O2ER (%) Sevo A 23 (7) 24 (6) 35 (12) * † Sevocris 20 (3) 25 (6) 36 (13)* † Temp (°C) Sevo A 38.3 (0.4) 38.4 (0.5) 38.5 (0.5) Sevocris 38.6 (0.6) 38.6 (0.4) 38.7 (0.5) Mean (SD); RR=respiratory rate; P peak=airway peak pressure; P plato=airway plato pressure; ComplDyn=dynamic compliance; Vt=tidal volume; EtCO2=end-tidal CO2; pH art=arterial pH; PaCO2=partial pressure of arterial CO2; PaO2=partial pressure of arterial oxygen; SaO2=arterial oxygen saturation; Lactate=arterial lactate; PvO2=partial pressure of mixed venous oxygen; SvO2=mixed venous saturation; DO I=oxygen delivery index; 2 VO2I=oxygen consumption index; O2ER=oxygen extraction ratio; Temp=temperature. * P<0.05 compared to 1 MAC; † P<0.05 compared to 0.5 MAC. significant increases in heart rate from the awake state during the administration of 1.2-2.0 MAC. In the present study, heart rate decreased when the MAC was augmented from 0.5 to 1.0 and 1.5, but the values obtained remained in the physiological range for this group of animals, and bradycardia was not verified. The effects of both tested sevofluranes on cardiac performance (LVSWI, RVSWI, SVI and EDVI) were the same and are in accordance with the literature. The influence of sevoflurane on performance of the right ventricle (RV) was studied by Kerbaul and colleagues, who observed a significant decrease in the RV stroke work with 1 and 1.5 MAC of sevoflurane. 20 Ventilation was kept constant in order to maintain the Copyright © 2010 CLINICS 535