Red1 binds Smt3 chains F-M Lin et al Sym M, Engebrecht JA, Roeder GS (1993) Zip1 is a synaptonemal complex protein required for meiotic chromosome synapsis. Cell 72: 365–378 Tsubouchi T, Macqueen AJ, Roeder GS (2008) Initiation of meiotic chromosome synapsis at centromeres in budding yeast. Genes Dev 22: 3217–3226 Tsubouchi T, Roeder GS (2005) A synaptonemal complex protein promotes homology-independent centromere coupling. Science 308: 870–873 Tsubouchi T, Zhao H, Roeder GS (2006) The meiosis-speciﬁc Zip4 protein regulates crossover distribution by promoting sy- naptonemal complex formation together with zip2. Dev Cell 10: 809–819 Wakayama T, Kondo T, Ando S, Matsumoto K, Sugimoto K (2001) Pie1, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae. Mol Cell Biol 21: 755–764 Wan L, de los Santos T, Zhang C, Shokat K, Hollingsworth NM (2004) Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast. Mol Biol Cell 15: 11–23 Woltering D, Baumgartner B, Bagchi S, Larkin B, Loidl J, de los Santos T, Hollingsworth NM (2000) Meiotic segregation, synap- sis, and recombination checkpoint functions require physical interaction between the chromosomal proteins Red1p and Hop1p. Mol Cell Biol 20: 6646–6658 Zubenko GS, Jones EW (1981) Protein degradation, meiosis and sporulation in proteinase-deﬁcient mutants of Saccharomyces cerevisiae. Genetics 97: 45–64 The EMBO Journal is published by Nature Publishing Group on behalf of European Molecular Biology Organization. This article is licensed under a Creative Commons Attribution-Noncommercial- Share Alike 3.0 Licence. [http://creativecommons.org/ licenses/by-nc-sa/3.0/] 596 The EMBO Journal VOL 29 | NO 3 | 2010 & 2010 European Molecular Biology Organization