18 The Korean Journal of Internal Medicine Vol. 26, No. 1, March 2011 of the secretion of granulocyte colony-stimulating factor. Am J Physiol Lung Cell Mol Physiol 2005;288:L238-L250. 53. Venet F, Lepape A, Debard AL, Bienvenu J, Bohé J, Monneret G. The Th2 response as monitored by CRTH2 or CCR3 expression is severely decreased during septic shock. Clin Immunol 2004;113:278-284. 54. Hamada K, Yamada Y, Kamada Y, et al. Prostaglandin D2 and interleukin-5 reduce CRTH2 surface expression on human eosinophils. Allergol Int 2004;53:179-184. 55. Hammad H, Kool M, Soullié T, et al. Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells. J Exp Med 2007;204:357-367. 56. Trivedi SG, Newson J, Rajakariar R, et al. Essential role for hematopoietic prostaglandin D2 synthase in the control of delayed type hypersensitivity. Proc Natl Acad Sci U S A 2006;103:5179-5184. 57. Shimura C, Satoh T, Igawa K, et al. Dendritic cells express hematopoietic prostaglandin D synthase and function as a source of prostaglandin D2 in the skin. Am J Pathol 2010;176:227-237. 58. Wang YH, Ito T, Wang YH, et al. Maintenance and polarization of human TH2 central memory T cells by thymic stromal lym- phopoietin-activated dendritic cells. Immunity 2006;24:827- 838. 59. Vinall SL, Townsend ER, Pettipher R. A paracrine role for chemoattractant receptor-homologous molecule expressed on T helper type 2 cells (CRTH2) in mediating chemotactic activation of CRTH2+ CD4+ T helper type 2 lymphocytes. Immunology 2007;121:577-584. 60.Gyles SL, Xue L, Townsend ER, Wettey F, Pettipher R. A domi- nant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+ CD4+ Th2 lymphocytes in response to mast cell supernatants. Immunology 2006;119:362-368. 61. Abe H, Takeshita T, Nagata K, et al. Molecular cloning, chromo- some mapping and characterization of the mouse CRTH2 gene, a putative member of the leukocyte chemoattractant receptor fami- ly. Gene 1999;227:71-77. 62.Chevalier E, Stock J, Fisher T, et al. Cutting edge: chemoattrac- tant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment. J Immunol 2005;175:2056-2060. 63.Satoh T, Moroi R, Aritake K, et al. Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor. J Immunol 2006;177:2621-2629. 64.Holgate ST. The inflammation-repair cycle in asthma: the pivotal role of the airway epithelium. Clin Exp Allergy 1998;28 Suppl 5:97-103. 65. Chiba T, Kanda A, Ueki S, et al. Prostaglandin D2 induces IL-8 and GM-CSF by bronchial epithelial cells in a CRTH2-indepen- dent pathway. Int Arch Allergy Immunol 2006;141:300-307. 66.Chan CL, Jones RL, Lau HY. Characterization of prostanoid receptors mediating inhibition of histamine release from anti- IgE-activated rat peritoneal mast cells. Br J Pharmacol 2000;129:589-597. 67. Mesquita-Santos FP, Vieira-de-Abreu A, Calheiros AS, et al. Cutting edge: prostaglandin D2 enhances leukotriene C4 synthe- sis by eosinophils during allergic inflammation: synergistic in vivo role of endogenous eotaxin. J Immunol 2006;176:1326-1330. 68.Monneret G, Boumiza R, Gravel S, et al. Effects of prostaglandin D(2) and 5-lipoxygenase products on the expression of CD203c and CD11b by basophils. J Pharmacol Exp Ther 2005;312:627- 634. 69.Okada N, Fukagawa K, Tanaka M, et al. CRTH2 expression on eosinophils from atopic patients. Invest Ophthalmol Vis Sci 2004;45:4853-B177. 70.Huang JL, Gao PS, Mathias RA, et al. Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma and differentially influence mRNA stability. Hum Mol Genet 2004;13:2691-2697. 71. Luster AD, Tager AM. T-cell trafficking in asthma: lipid mediators grease the way. Nat Rev Immunol 2004;4:711-724. 72. Hata AN, Breyer RM. Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modula- tion. Pharmacol Ther 2004;103:147-166. 73. Oguma T, Palmer LJ, Birben E, Sonna LA, Asano K, Lilly CM. Role of prostanoid DP receptor variants in susceptibility to asth- ma. N Engl J Med 2004;351:1752-1763.