10 treatment with the inhaled long-acting beta2-agonists arformoterol and salmeterol. Medicine (Baltimore) 2008; 87: 319–328. 4 Huiart L, Ernst P, Suissa S. Cardiovascular morbidity and mortality in COPD. Chest 2005; 128: 2640–2646. 5 Malerba M, Romanelli G. Early cardiovascular involvement in chronic obstructive pulmonary disease. Monaldi Arch Chest Dis 2009, 71: 59–65. 6 Agusti A. Thomas N. Chronic obstructive pulmonary disease: a systemic disease. Proc Am Thorac Soc 2006; 3: 478–481. 7 Zhang H, Cai B. The impact of tobacco on lung health in China. Respirology 2003; 8: 17–21. 8 Tuder RM. Aging and cigarette smoke: fueling the fire. Am J Respir Crit Care Med 2006; 174: 490–491. 9 Cazzola M, Donner CF, Hanania NA. One hundred years of chronic obstructive pulmonary disease (COPD). Respir Med 2007; 101: 1049–1065. 10 Yanbaeva DG, Dentener MA, Creutzberg EC, et al. Systemic effects of smoking. Chest 2007; 131: 1557–1566. 11 Almagro P, López García F, Cabrera F, et al. Comorbidity and gender-related differences in patients hospitalized for COPD. The ECCO study. Respir Med 2010; 104: 253–259. 12 de Torres JP, Cote CG, López MV, et al. Sex differences in mortality in patients with COPD. Eur Respir J 2009; 33: 528–535. 13 Basili S, Ferroni P, Vieri M, et al. Lipoprotein(a) serum levels in patients affected by chronic obstructive pulmonary disease. Atherosclerosis 1999; 147: 249–252. 14 de Torres JP, Casanova C, Hernández C, et al. Gender and COPD in patients attending a pulmonary clinic. Chest 2005; 128: 2012–2016. 15 Schroeder SA. Shattuck Lecture. We can do better improving the health of the American people. N Engl J Med 2007; 357: 1221–1228. 16 Schroeder SA. Tobacco control in the wake of the 1998 master settlement agreement. N Engl J Med 2004; 350: 293–301. 17 18 19 20 21 22 23 24 25 Cui H et al. Cardiovascular diseases in COPD Boggia B, Farinaro E, Grieco L, et al. Burden of smoking and occupational exposure on etiology of chronic obstructive pulmonary disease in workers of Southern Italy. J Occup Environ Med 2008; 50: 366–370. Mills NL, Donaldson K, Hadoke PW, et al. Adverse cardiovascular effects of air pollution. Nat Clin Pract Cardiovasc Med 2009; 6: 36–44. Sidney S, Sorel M, Quesenberry CP Jr, et al. COPD and incident cardiovascular disease hospitalizations and mortality: Kaiser Permanente Medical Care Program. Chest 2005; 128: 2068–2075. Macnee W, Maclay J, McAllister D. Cardiovascular injury and repair in chronic obstructive pulmonary disease. Proc Am Thorac Soc 2008; 5824–5833. Curkendall SM, DeLuise C, Jones JK, et al. cardiovascular disease in patients with chronic obstructive pulmonary disease, Saskatchewan Canada cardiovascular disease in COPD patients. Ann Epidemiol 2006; 16: 63–70. Brassard P, Ferland A, Marquis K, et al. Impact of diabetes, chronic heart failure, congenital heart disease and chronic obstructive pulmonary disease on acute and chronic exercise responses. Can J Cardiol 2007; 23 (Suppl ): S89–S96. Rusinaru D, Saaidi I, Godard S, et al. Impact of chronic obstructive pulmonary disease on long-term outcome of patients hospitalized for heart failure. Am J Cardiol 2008; 101: 353–358. Sin DD, Paul SF. Impact of cancers and cardiovascular diseases in chronic obstructive pulmonary disease. Curr Opin Pulm Med 2008; 14: 115–121. Robert A, Stockley. Progression of chronic obstructive Pulmonary disease: impact of inflammation, comorbidities and therapeutic intervention. Current Medical Research and Opinion 2009; 25: 1235–1245. Journal of Geriatric Cardiology | jgc@jgc301.com; http://www.jgc301.com