A. Nordle Gilliver, S. Griffin and M. Harris Reed, K. E., Xu, J. & Rice, C. M. (1997). Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: properties of the NS5A-associated kinase. J Virol 71, 7187–7197. Shepard, C. W., Finelli, L. & Alter, M. J. (2005). Global epidemiology of hepatitis C virus infection. Lancet Infect Dis 5, 558–567. Tanji, Y., Kaneko, T., Satoh, S. & Shimotohno, K. (1995). Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A. J Virol 69, 3980–3986. Tellinghuisen, T. L., Marcotrigiano, J., Gorbalenya, A. E. & Rice, C. M. (2004). The NS5A protein of hepatitis C virus is a zinc metallo- protein. J Biol Chem 279, 48576–48587. Tellinghuisen, T. L., Marcotrigiano, J. & Rice, C. M. (2005). Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase. Nature 435, 374–379. Tellinghuisen, T. L., Foss, K. L. & Treadaway, J. (2008a). Regulation of hepatitis C virion production via phosphorylation of the NS5A protein. PLoS Pathog 4, e1000032. Wakita, T., Pietschmann, T., Kato, T., Date, T., Miyamoto, M., Zhao, Z., Murthy, K., Habermann, A., Krausslich, H. G. & other authors (2005). Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med 11, 791– 796. 2432 Journal of General Virology 91