C.C. Santana et al. 40 Caldas A, Favali C, Aquino D, et al. Balance of IL-10 and interferon- γ plasma levels in human visceral leishmaniasis: implications in the pathogenesis. BMC Infect Dis 2005; 5: 113. 41 Lage RS, Oliveira GC, Busek SU, et al. Analysis of the cytokine proﬁle in spleen cells from dogs naturally infected by Leishmania chagasi. Vet Immunol Immunopathol 2007; 115 (1–2): 135 –145. 42 de Lima VM, Peiro JR & de Oliveira Vasconcelos R. IL-6 and TNF-α production during active canine visceral leishmaniasis. Vet Immunol Immunopathol 2007; 115 (1–2): 189 –193. 43 Poeck H, Wagner M, Battiany J, et al. Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help. Blood 2004; 103 (8): 3058 –3064. 44 Hargreaves DC, Hyman PL, Lu TT, et al. A coordinated change in chemokine responsiveness guides plasma cell movements. J Exp Med 2001; 194 (1): 45 –56. 45 Manz RA, Arce S, Cassese G, Hauser AE, Hiepe F & Radbruch A. Humoral immunity and long-lived plasma cells. Curr Opin Immunol 2002; 14 (4): 517–521. Parasite Immunology 46 Ato M, Stager S, Engwerda CR & Kaye PM. Defective CCR7 expression on dendritic cells contributes to the development of visceral leishmaniasis. Nat Immunol 2002; 3 (12): 1185 –1191. 47 Smelt SC, Engwerda CR, McCrossen M & Kaye PM. Destruction of follicular dendritic cells during chronic visceral leishmaniasis. J Immunol 1997; 158 (8): 3813 –3821. 48 Andreotti R, Oliveira JM, Silva EA, Oshiro LM & Matos MD. Occurrence of Neospora caninum in dogs and its correlation with visceral leishmaniasis in the urban area of Campo Grande, Mato Grosso do Sul, Brazil. Vet Parasitol 2005; 135 (3 – 4): 375 – 379. 49 Trapp SM, Dagnone AS, Vidotto O, Freire RL, Amude AM & de Morais HS. Seroepidemiology of canine babesiosis and ehrlichiosis in a hospital population. Vet Parasitol 2006; 140 (3 – 4): 223 –230. 50 Pearson RD, Cox G, Evans T, Smith DL, Weidel D & Castracane J. Wasting and macrophage production of tumor necrosis factor/ cachectin and interleukin 1 in experimental visceral leishmaniasis. Am J Trop Med Hyg 1990; 43 (6): 640–649. 524 © 2008 The Authors Journal compilation © 2008 Blackwell Publishing Ltd, Parasite Immunology, 30, 515–524