Curr Neurol Neurosci Rep (2012) 12:511–519 Disclosure The author has no conflicts of interest to disclose. G.E.M. is funded by Award Number R01AG036469 from the National Insti- tute on Aging. Open Access This article is distributed under the terms of the Crea- tive Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. References Papers of particular interest, published recently, have been highlighted as: Of importance Of major importance 1. Sousa RM, et al. Contribution of chronic diseases to disability in elderly people in countries with low and middle incomes: A 10/66 Dementia Research Group population-based survey. Lancet. 2009;374(9704):1821–30. 2. Aisen PS. Pre-dementia Alzheimer's trials: overview. J Nutr Health Aging. 2010;14(4):294. 3. Alzheimer´s Disease International, World Alzheimer's Report. 2009. Prince M, Jackson, J, editors. London: Alzheimer's Disease International; 2009. 4. Nitrini R, et al. Prevalence of dementia in Latin America: A collaborative study of population-based cohorts. Int Psychogeriatr. 2009;21(4):622–30. 5. Maestre GE. Dementia in Latin America and the Caribbean: an overlooked epidemic. Neuroepidemiology. 2008;31(4):252–3. 6. Sternberg SA, Wolfson C, Baumgarten M. Undetected dementia in community-dwelling older people: the Canadian Study of Health and Aging. J Am Geriatr Soc. 2000;48(11):1430–4. 7. Alzheimer's Disease International, World Alzheimer Report. 2011. The benefits of early diagnosis and intervention. Prince M, Brice R, Ferri C, editors. London: Alzheimer´s Disease Interna- tional; 2011. Thoroughly reviews the literature on the benefits of early diagnosis, with particular emphasis on low-to-middle-in- come countries. 8. World Health Organization. Mental Health Gap Action Programme: scaling up care for mental, neurological and sub- stance use disorders. Geneva: World Health Organization; 2008. 9. World Health Organization, Alzheimer's Disease International. Dementia: a public health priority. 2012: Geneva. p. 112. Reviews the literature on the current status and need to address the high global numbers of people with dementia with special emphasis on the situation in low-to-middle-income countries is comprenhensive. 10. Ferri CP, et al. Global prevalence of dementia: a Delphi consensus study. Lancet. 2005;366(9503):2112–7. 11. Ineichen B. The epidemiology of dementia in Africa: A review. Soc Sci Med. 2000;50(11):1673–7. 12. Acosta-Baena N, et al. Pre-dementia clinical stages in presenilin 1 E280A familial early-onset Alzheimer’s disease: A retrospective cohort study. Lancet Neurol. 2011;10(3):213–20. 13. Ceaser M. Left by the lakeside. Lancet. 2004;364(9434):569–70. 14. Kaur M, Balgir PP. APOE2 and consanguinity: A risky com- bination for Alzheimer's disease. J Alzheimers Dis. 2005;8 (3):293–7. 15. Jorm AF, Jolley D. The incidence of dementia: A meta-analysis. Neurology. 1998;51(3):728–33. 517 16. U.S. Census Bureau, International Data Base. 2012. http:// www.census.gov/population/international/data/idb/information Gateway.php. Retrieved 25 March 2012. 17. Sinha RN. Make dementia a public health priority in India. Indian J Public Health. 2011;55(2):67–9. 18. Lopez OL. The growing burden of Alzheimer’s disease. Am J Manag Care. 2011;17(13):S339–45. 19. Kelishadi R. Childhood overweight, obesity, and the metabolic syn- drome in developing countries. Epidemiol Rev. 2007;29:62–76. 20. Boissonnet C, et al. Educational inequalities in obesity, abdominal obesity, and metabolic syndrome in seven Latin American cities: The CARMELA Study. Eur J Cardiovasc Prev Rehabil. 2011;18 (4):550–6. 21. Subramanian SV, et al. Weight of nations: a socioeconomic anal- ysis of women in low- to middle-income countries. Am J Clin Nutr. 2011;93(2):413–21. 22. Popkin BM. The shift in stages of the nutrition transition in the developing world differs from past experiences! Public Health Nutr. 2002;5(1A):205–14. 23. McKhann G, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34(7):939–44. 24. McKeith IG, et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology. 1996;47(5):1113–24. 25. Zerr I, et al. Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease. Brain. 2009;132(Pt 10):2659–68. 26. Sperling RA, et al. Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7 (3):280–92. 27. McKhann GM, et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging- Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):263–9. 28. Jack Jr CR, et al. Introduction to the recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):257–62. 29. Mayeux R, Stern Y, Spanton S. Heterogeneity in dementia of the Alzheimer type: evidence of subgroups. Neurology. 1985;35 (4):453–61. 30. Kaye JA. Diagnostic challenges in dementia. Neurology. 1998;51 (1):S45–52. discussion S65-7. 31. Baiyewu O. Dementia in Nigeria. Archives of Ibadan Medicine. 2003;4(1):21–2. 32. Muela SH, Mushi AK, Ribera JM. The paradox of the cost and affordability of traditional and government health services in Tan- zania. Health Policy Plan. 2000;15(3):296–302. 33. Romero-Salazar A, Roque-Rujano R, Maestre GE. Knowlwdge, beliefs and report of the practice of general practicioners in primary attention in Maracaibo, Venezuela about dementia. Investigacion en Salud. 2007;9(1):10–5. 34. Dias A, Patel V. Closing the treatment gap for dementia in India. Indian J Psychiatry. 2009;51 Suppl 1:S93–7. 35. Maestre GE, Rojas-Ruiz OM, Biomedicalization of cognitive deficits: Lessons from the Maracaibo Aging Study and implications for de- veloping countries. Alzheimer´s & Dementia, 2009. 5(4): p. P91. 36. Boggatz T, Dassen T. Ageing, care dependency, and care for older people in Egypt: a review of the literature. J Clin Nurs. 2005;14 (8B):56–63. 37. Chu LW, Chi I. Nursing homes in China. J Am Med Dir Assoc. 2008;9(4):237–43.