Bardy and Pallotto REFERENCES Bathellier, B., Lagier, S., Faure, P., and Lledo, P.-M. (2006). Circuit properties generating gamma oscillations in a network model of the olfactory bulb. J. Neurophysiol. 95, 2678–2691. Breton-Provencher, V., Lemasson, M., Peralta, M. R. III, and Saghatelyan, A. (2009). Interneurons produced in adulthood are required for the normal function- ing of the olfactory bulb network and for the execu- tion of selected olfactory behaviors. J. Neurosci. 29, 15245–15257. Clelland, C. D., Choi, M., Romberg, C., Clemenson, G. D., Fragniere, A., Tyers, P., Jessberger, S., Saksida, L. M., Barker, R. A., Gage, F. H., and Bussey, T. J. (2009). A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science 325, 210–213. Deng, W., Saxe, M. D., Gallina, I. S., and Gage, F. H. (2009). Adult-born hippocampal dentate gran- ule cells undergoing maturation modulate learn- ing and memory in the brain. J. Neurosci. 29, 13532–13542. Gourevitch, B., Kay, L. M., and Martin, C. (2010). Directional coupling from the olfactory bulb to the hippocampus during a go/no-go odor discrimina- tion task. J. Neurophysiol. doi: 10.1152/jn.01075.2009. (in press). Imayoshi, I., Sakamoto, M., Ohtsuka, T., Takao, K., Miyakawa, T., Yamaguchi, M., Mori, K., Ikeda, T., Itohara, S., and Kageyama, R. (2008). Roles of con- tinuous neurogenesis in the structural and functional integrity of the adult forebrain. Nature Neurosci. 11, 1153–1161. Kitamura, T., Saitoh, Y., Takashima, N., Murayama, A., Niibori,Y.,Ageta, H., Sekiguchi, M., Sugiyama, H., and Inokuchi, K. (2009). Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory. Cell 139, 814–827. Lagier, S., Panzanelli, P., Russo, R. E., Nissant, A., Bathellier, B., Sassoe-Pognetto, M., Fritschy, J., and Lledo, P. M. (2007). GABAergic inhibition at den- drodendritic synapses tunes {gamma} oscillations in the olfactory bulb. Proc. Natl. Acad. Sci. 104, 7259–7264. Lazarini, F., Mouthon, M.-A., Gheusi, G., de Chaumont, F., Olivo-Marin, J.-C., Lamarque, S., Abrous, D. N., Boussin, F. D., and Lledo, P.-M. (2009). Cellular and behavioral effects of cranial irradiation of the sub- ventricular zone in adult mice. PLoS One 4, e7017. doi: 10.1371/journal.pone.0007017. Moreno, M. M., Linster, C., Escanilla, O., Sacquet, J., Didier, A., and Mandairon, N. (2009). Olfactory per- ceptual learning requires adult neurogenesis. Proc. Natl. Acad. Sci. 106, 17980–17985. What role for neurons generated in adults? Mouret, A., Gheusi, G., Gabellec, M., de Chaumont, F., Olivo-Marin, J., and Lledo, P. M. (2008). Learning and survival of newly generated neurons: when time matters. J. Neurosci. 28, 11511–11516. Nissant,A., Bardy, C., Katagiri, H., Murray, K., and Lledo, P. M. (2009).Adult neurogenesis promotes synaptic plas- ticity in the olfactory bulb. Nat. Neurosci. 12, 728–730. Valley, M. T., Mullen, T. R., Schultz, L. C., Sagdullaev, B. T., and Firestein, S. (2009). Ablation of mouse adult neurogenesis alters olfactory bulb structure and olfac- tory fear conditioning. Front. Neurogen. 1: 1–13. doi: 10.3389/neuro.22.003.2009. Received: 10 February 2010; paper pending published: 25 February 2010; Accepted: 26 February 2010; published online: 26 March 2010. Citation: Bardy C and Pallotto M (2010) What happens to olfaction without adult neurogenesis? Front. Neurosci. 4:24. doi: 10.3389/fnnes.2010.00002 This article was submitted to Frontiers in Neurogenesis, a specialty of Frontiers in Neuroscience. Copyright © 2010 Bardy and Pallotto. This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited. Frontiers in Neuroscience | Neurogenesis March 2010 | Volume 4 | Article 24 | 4