W126 Nucleic Acids Research, 2012, Vol. 40, Web Server issue Conﬂict of interest statement. None declared. REFERENCES 1. Bell,D., Berchuck,A., Birrer,M., Chien,J., Cramer,D.W., Dao,F., Dhir,R., DiSaia,P., Gabra,H., Glenn,P. et al. (2011) Integrated genomic analyses of ovarian carcinoma. Nature, 474, 609–615. 2. Kalinina,J., Peng,J., Ritchie,J.C. and Van Meir,E.G. (2011) Proteomics of gliomas: initial biomarker discovery and evolution of technology. Neuro Oncol., 13, 926–942. 3. Chin,L., Meyerson,M., Aldape,K., Bigner,D., Mikkelsen,T., VandenBerg,S., Kahn,A., Penny,R., Ferguson,M.L., Gerhard,D.S. et al. (2008) Comprehensive genomic characterization deﬁnes human glioblastoma genes and core pathways. Nature, 455, 1061–1068. 4. Schreiber,S.L., Shamji,A.F., Clemons,P.A., Hon,C., Koehler,A.N., Munoz,B., Palmer,M., Stern,A.M., Wagner,B.K., Powers,S. et al. (2010) Towards patient-based cancer therapeutics. Nat. Biotechnol., 28, 904–906. 5. Bast,R.C. Jr (2012) Molecular approaches to personalizing management of ovarian cancer. Ann. Oncol., 22(Suppl. 8), viii5–viii15. 6. Mok,T.S.K. (2011) Personalized medicine in lung cancer: what we need to know. Nat. Rev. Clin. Oncol., 8, 661–668. 7. Barabasi,A.L. and Oltvai,Z.N. (2004) Network biology: understanding the cell’s functional organization. Nat. Rev. Genet., 5, 101–113. 8. Kim,J. and Tan,K. (2010) Discover protein complexes in protein-protein interaction networks using parametric local modularity. BMC Bioinformatics, 11, 521. 9. Voevodski,K., Teng,S.H. and Xia,Y. (2009) Finding local communities in protein networks. BMC Bioinformatics, 10, 297. 10. Chuang,H.Y., Lee,E., Liu,Y.T., Lee,D. and Ideker,T. (2007) Network-based classiﬁcation of breast cancer metastasis. Mol. Syst. Biol., 3, 140. 11. Jia,P., Zheng,S., Long,J., Zheng,W. and Zhao,Z. (2011) dmGWAS: dense module searching for genome-wide association studies in protein-protein interaction networks. Bioinformatics, 27, 95–102. 12. Ideker,T., Ozier,O., Schwikowski,B. and Siegel,A.F. (2002) Discovering regulatory and signalling circuits in molecular interaction networks. Bioinformatics, 18(Suppl. 1), S233–S240. 13. Cox,D.R. and Oakes,D. (1984) Analysis of Survival Data. Chapman and Hall, London, New York. 14. Hosmer,D.W. and Lemeshow,S. (1999) Applied Survival Analysis: Regression Modeling of Time to Event Data. Wiley, New York. 15. Keshava Prasad,T.S., Goel,R., Kandasamy,K., Keerthikumar,S., Kumar,S., Mathivanan,S., Telikicherla,D., Raju,R., Shafreen,B., Venugopal,A. et al. (2009) Human Protein Reference Database– 2009 update. Nucleic Acids Res., 37, D767–D772. 16. Tibes,R., Qiu,Y.H., Hennessy,B., Andreeff,M., Miiis,G.B. and Kornblau,S.M. (2006) Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells. Mol. Cancer Ther., 5, 2512–2521.