Peripheral giant cell granuloma orrhage, hemosiderin, inflammatory cells, and of resection of the lesion and closure of the de- newly formed bone or calcified material may also fect with a mucosal graft. Postoperative healing be seen throughout the cellular connective tis- was uneventful (Figure 2) and no sign of recur- sue.5,6 The lesion can develop at any age, though rence was observed. Histopathological examina- it is more common between the fifth and sixth de- tion of the lesion revealed rich inflammatory cell cades of life, and shows a slight female predilec- infiltration under the epithelia, a great number of tion.4-7 PGCG is a soft tissue lesion that infrequent- multinuclear giant cells between the inflamma- ly affects the underlying bone, although the latter tory cells, and epithelioid histiocytes around the may undergo superficial erosion.3,7,8 In the present inflammatory cells. Also there were many conges- report, three cases of PGCG are presented at the tive vessels, hemorrhages, and hemosiderin over same location in the mandible. the cellular connective tissue. Final diagnosis was made as PGCG. CASE REPORTS Case 1 Case 2 A 57-year-old otherwise healthy woman was A 81-year-old female patient with hypertension referred to our clinic for a gingival mass of the low- was referred to our clinic for soft swelling on the er jaw. The patient was edentulous and had been anterior mandible. The patient was edentulous and using a complete denture for more than 10 years. had been using a complete denture for about 15 The tumoral lesion was located on the edentulous years. The lesion had appeared one month before. anterior mandible, and the patient did not know The patient reported neither pain nor alteration of how long the lesion had been there. The patient the size of the mass. Clinical exploration revealed reported neither pain nor alteration of the size of a red-bluish nodule, sessile lesion located on the the mass. Clinical exploration revealed a red and anterior mandibular alveolar crest (Figure 3). The bluish nodule, sessile lesion located on the anteri- lesion measured 1x0.5 cm in size and had no ul- or mandibular alveolar crest (Figure 1). The lesion cerated surface. Radiological examination showed measured 1x0.5 cm in size and had no ulcerated no evidence of bony involvement. surface. Radiological examination revealed no evi- Treatment consisted of resection of the lesion dence of bony involvement. Treatment consisted and closure of the defect with a mucosal graft. Postoperative healing was uneventful (Figure 4). Histopathological examination confirmed the di- agnosis of PGCG (Figure 5). Through the one-year follow-up period, there were no complaints or re- currences. Figure 1. Clinical view of the lesion of the first patient. Case 3 A 53-year-old otherwise healthy male patient was edentulous and had been using a complete denture for more than 10 years. The patient re- ported a painless lesion at the anterior mandible Figure 2. Clinical view of the postoperative healing of the first patient. Figure 3. Clinical view of the lesion of the second patient. 330 European Journal of Dentistry