interesting feature is that both cases had these skin lesions on the neck, which is an unusual site for granular para- keratosis. This finding may be because the neck is an area susceptible to profuse sweating during hot season. Many treatments have been attempted, but there is no optimal therapy for granular parakeratosis. Some cases have resolved spontaneously, while others resolved by stopping deodorant use. Various responses have been observed after treatment with oral and topical cortico- steroid, oral and topical retinoid, oral and topical anti- fungal agents, oral antibiotics, topical vitamin D analo- gues, topical ammonium lactate, cryotherapy and botuli- num toxin injection. In our case, the skin lesions dis- appeared as the temperature dropped. This phenomenon supports the aforementioned hypothesis that granular parakeratosis confined to eccrine ostia may be associated high temperature. In conclusion, we report a unique histopathologic variant of granular parakeratosis that mainly affected the eccrine ostia. Granular Parakeratosis of Eccrine Ostia REFERENCES 1. Wang L, Yang L, Wang G, Gao T. Granular parakeratosis of eccrine ostia. Am J Dermatopathol 2008;30:65-66. 2. Northcutt AD, Nelson DM, Tschen JA. Axillary granular parakeratosis. J Am Acad Dermatol 1991;24:541-544. 3. Scheinfeld NS, Mones J. Granular parakeratosis: pathologic and clinical correlation of 18 cases of granular parakeratosis. J Am Acad Dermatol 2005;52:863-867. 4. Neri I, Patrizi A, Guerrini V, Fanti PA. Granular parakeratosis in a child. Dermatology 2003;206:177-178. 5. Metze D, Rütten A. Granular parakeratosis - a unique acquired disorder of keratinization. J Cutan Pathol 1999;26: 339-352. 6. Pock L, Cermáková A, Zipfelová J, Hercogová J. Incidental granular parakeratosis associated with molluscum contagi- osum. Am J Dermatopathol 2006;28:45-47. 7. Pock L, Hercogová J. Incidental granular parakeratosis associated with dermatomyositis. Am J Dermatopathol 2006; 28:147-149. 8. Resnik KS, Kantor GR, DiLeonardo M. Dermatophyte-related granular parakeratosis. Am J Dermatopathol 2004;26:70-71. 9. Resnik KS, DiLeonardo M. Incidental granular parakeratotic cornification in carcinomas. Am J Dermatopathol 2007;29: 264-269. 10. Resnik KS, DiLeonardo M. Follicular granular parakeratosis. Am J Dermatopathol 2003;25:428-429. Vol. 24, No. 2, 2012 205