Aneiros-Fernandez et al J Clin Med Res • 2010;2(4):185-188 Figure 2. (A) Tumor ill-defined in dermal-hypodermal junction and subcutaneous fat. (Haematoxylin-eosin, original magnification: x 40); (B) Nests and sheets of cells containing eosinophilic cytoplasmic granules (haematoxylin-eosin, original magnification: x 200). sociated calcifications were observed within the mass. Ul- trasound revealed a poorly-defined, hypoechoic solid lesion disrupting fascial planes with a strong acoustic shadowing. We classified the mass as category 4c under the Breast Im- aging Reporting and Data System (BI-RADS), i.e., with an estimated likelihood of malignancy of 50% - 90%. Results of fine needle aspiration cytology were inconclusive. Radiogu- ided tumorectomy was performed due to clinical suspicion of malignant tumor, evidencing an ill-defined, spiculated, and indurated lesion of 1.1 x 0.7 cm. Histological examina- tion showed an ill-defined firm nodule composed of compact nests and sheets of cells containing eosinophilic cytoplas- mic granules with well-defined cell borders and prominent nucleoli (Fig. 2). This lesion was location in dermo-hypo- dermal junction and subcutaneous fat. The tumor cells were arranged in a fascicular pattern with an infiltrating growth Figure 3. Positive staining of neoplastic cells for: (A) CD 68 (original magnification: x 400) and(B) S-100 protein (original magnification: x 400). 186 Articles © The authors | Journal compilation © J Clin Med Res and Elmer Press™ | www.jocmr.org