126 Aromatherapy and breast cancer Figure 1. Psychologic effects of aromatherapy massage on breast cancer patients. (A) The subjects filled out the forms of HADS test 1 month before aromatherapy massage, immediately before the first massage fifth massage and eighth massage and 1 month after massage. (B) The subjects filled out the forms for psychologic tests (STAI) 1 month before aromatherapy massage, immediately before and after the first massage, fifth massage and eighth massage and 1 month after massage. (C) The subjects filled out the forms of POMS test 1 month before aromatherapy massage, immediately before the first, fifth and eighth massage and 1 month after massage. *P50.05, **P50.01, NS: not significant: not done, by repeated measures ANOVA or by paired t-test. *P50.05, (**)P50.01, by Bonferroni test. CD4-CXCR3-positive lymphocytes have a tendency to increase after the first and eighth aromatherapy massage, compared with those before the first and eighth massage. CD4-CCR4-positive lymphocytes also tend to increase by the first aromatherapy session. Discussion It is well known that aromatherapy is a representative complementary therapy to reduce anxiety. In our investigation, we gave aromatherapy massage to breast cancer patients to see if and how it ameliorated anxiety and depression and enhanced the immunologic state. First, we examined psychologic responses to aromather- apy massage using STAI, POMS and HADS. State anxiety scores of STAI are adequate to determine the short-term effects of aromatherapy. Especially, in STAI, state anxiety scores significantly decreased after each aromatherapy massage session. This result is in accord- ance with those of our previous study (1) and those of Wilkinson et al. (5).