Young-Ho Kim, et al. monitoring, institute lifesaving dietary modifications, or suggest cautious management of patients who are awaken- ing from anesthesia after surgery. It might also stimulate the search for alternative pharmacologic agents that do not alter facilitation of the glottic closure response without losing their specific effects. A series of basic research using various animal species should be preceded before applying the precise mechanism of this reflex to human in the future. REFERENCES 1. Suzuki M, Kirchner JA. Sensory fibers in the recurrent laryngeal nerve. An electrophy Siological Study of some larygeal afferent fibers in the recurrent laryngeal nerve of the cat. Ann Otol Rhinol Laryngol 1969;78:21-31. 2. Murakami Y, Kirchner JA. Mechanical and physiological pro- perties of reflex laryngeal closure. Ann Otol Rhinol Laryngol 1972;81:59-71. 3. Kirchner JA. Laryngeal reflex systems. In: Baer T, Sasaki C, Harris KS, editors. Laryngeal function in phonation and respira- tion. Boston: College Hill Press; 1987. p.65-70. 4. Sasaki CT, Suzuki M. Laryngeal reflexes in cat, dog, and man. Arch Otolaryngol 1976;102:400-2. 5. Kim YH, Hong WP, Kim KM, Kim HY. Superior laryngeal nerve brain stem evoked response in the cat. Ann Otol Rhinol Laryngol 1997;106:101-8. 6. Kim KM, Kim YH. An experimental study of superior laryngeal nerve brain stem evoked response in the dog. Korean J Otolary- ngol 1998;41:501-6. 7. Goding GS, Richardson MA, Trachy RE. Laryngeal chemoreflex: anatomic and physiologic study by use of the superior laryngeal nerve in the piglet. Otolaryngol Head Neck Surg 1987;97:28-38. 8. Ludlow CL, Van Pelt F, Koda J. Characteristics of late responses to superior laryngeal nerve stimulation in humans. Ann Otol Rhinol Laryngol 1992;101:127-35. 9. Downing SE, Lee JC. Laryngeal chemosensitivity: a possible mec- hanism for sudden infant death. Pediatrics 1975;55:640-9. 10. Leape LL; Holder TM, Franklin JD, Amoury RA, Ashcraft KW. Respiratory arrest in infants secondary to gastroesophageal reflux. Pediatrics 1977;60:924-8. 11. Herbst JJ, Book LS, Bray PF. Gastroesophageal reflux in the “near miss” sudden infant death syndrome. J Pediatr 1978;92:73-5. 12. Sasaki CT. Development of laryngeal function: etiologic signi- ficance in the sudden infant death syndrome. Laryngoscope 1979; 89:1964-82. 13. Brooks JG. Apnea of infancy and sudden infant death synd-rome. Am J Dis Child 1982;136:1012-23. 14. Lanier B, Richardson MA, Cummings C. Effect of hypoxia on laryngeal reflex apnea--implications for sudden infant death. Otolaryngol Head Neck Surg 1983;91:597-604. 15. Shifrin RY, Choplin RH. Aspiration in patients in critical care units. Radiol Clin North Am 1996;34:83-96. 16. Vincent MT, Goldman BS. Anaerobic lung infections. Am Fam Physician 1994;49:1815-20. 17. Roy TM, Ossorio MA, Cipolla LM, Fields CL, Snider HL, Anderson WH. Pulmonary complications after tricyclic antidepre- ssant overdose. Chest 1989;96:852-6. 18. Kim YH, Sasaki CT. Glottic closing force in an anesthetized, and awake pig model: biomechanical effects on the laryngeal closure reflex resulting from altered central facilitation Acta Otolaryngol 2001;121:310-4. 19. Lerman J, Oyston JP, Gallagher TM, Miyasaka K, Volgyesi GA, Burrows FA. The minimum alveolar concentration (MAC) and hemodynamic effects of halothane, isoflurane, and sevoflurane in newborn swine. Anesthesiology 1990;73:717-21. 20. Monitoring in anesthesia and critical care medicine. In: Blitt CD, editor. 2nd ed. New York: Churchill Livingstone Inc.; 1990. p.450-1. 21. Shapiro HM. Anesthesia effects upon cerebral blood flow, cerebral metabolism, electroencephalogram, and evoked potentials. In: Miller RD, editor. Anesthesia. 2nd ed. New York: Churchill Livingstone Inc.; 1986. p.1268-70. 22. Sasaki CT, Ho S, Kim YH. Critical role of central facilitation in the glottic closure reflex. Ann Otol Rhinol Laryngol 2001;110: 401-5. 23. Park HQ, Kim KM, Kim YH, Hong WP, Kim MS, Kim DY. Age dependence of laryngeal chemoreflex in puppies. Ann Otol Rhinol Laryngol 2001;110:956-63. 24. Jean A. Brain stem control of swallowing: neuronal network and cellular mechanisms. Physiol Rev2001;81:929-69. 25. Brain. In: Waxman SG, editor. Correlative neuroanatomy. 23rd ed. Stanford: Appleton & Lange; 1996. p.25-6. 26. Sessle BJ. Excitatory and inhibitory inputs to single neurones in the solitary tract nucleus and adjacent reticular formation. Brain Res 1973;53:319-31. 27. Sasaki CT, Jassin B, Kim YH, Hundal J, Rosenblatt W, Ross DA. Central facilitation of the glottic closure reflex in humans. Ann Otol Rhinol Laryngol 2003;112:293-7. 384 Yonsei Med J http://www.eymj.org Volume 50 Number 3 June 2009