8 smooth muscle cell line A10 under homocysteine (Hcy)- induced oxidative stress [87, 88]. Furthermore, the intra- cellular reactive oxygen species concentration signiﬁcantly decreased in A10 cells after SMAE treatment. Using MALDI- TOF-MS, the researchers suggested that the SMAE-induced inhibition of growth in Hcy-stimulated A10 cells occurred via the PKC/MAPK-dependent pathway [87, 88]. 6.2. Convulsive Disorders. Uncaria rhynchophylla (UR) and its major component, rhynchophylline, have demonstrated eﬀectiveness in treating convulsive disorders [109]. Lo et al. used SD rats with kainic acid (KA)-induced epileptic seizures and treated them with UR [86]. They then analyzed proteomic proﬁles from the frontal cortex and hippocampus of rat brain tissues and identiﬁed proteins diﬀerentially expressed between treated and untreated tissue. Macrophage migration inhibitory factor (MIF) and cyclophilin A were down-regulated and restored to normal levels in epileptic seizure rats after UR treatment. MIF has been considered as a counterregulator of normal neuronal actions and increases its expression level to reduce the chronotropic actions in SD rats [110]. Cyclophilin A is a phylogenetically-conserved protein and regulates immunosuppression [111]. These results showed that MIF and cyclophilin A involved in the mechanism of anticonvulsive eﬀect of UR. 7. Metabolomics Studies of Chinese Herbs in Diseases Another platform for systems biology research is meta- bolomics, involving the study of targeted small molecule metabolites (<1500 Da). In 1998, the metabolome was ﬁrst introduced in the elucidation of yeast gene function [112]. However, the application of this concept can be traced back to the development of traditional medicine; while metabonomics chemically tracks metabolites in urine, feces, and so forth, traditional medicine used color, smell, and taste to facilitate diagnoses. Over genomics and proteomics, metabolomics can provide a more solid link between geno- type and phenotype. 7.1. NMR-Based Metabolomics Analysis. NMR-based meta- bolomics is an attractive method for the study of medicinal herb eﬃcacy on disease symptoms. Using this method, nonselective and comprehensive analysis was performed on ginkgo extracts [113]. Moreover, Zhang et al. found that ginkgo extracts have multidirectional lipid-lowering eﬀects on the rat metabonome [114]. They suggested that ginkgo extracts possess metabolomic functions, including limitation of cholesterol absorption, inactivation of HMGCoA, and favorable regulation of essential polyunsaturated fatty acid proﬁles [114]. 7.2. Liquid Chromatography (LC)-TOF MS-Based Metabo- lomics. LC-MS-based metabolomics have been explored in many studies to date. Tan et al. performed LC-TOF MS to investigate the metabolites of aconitum alkaloids in rat urine after oral administration of aconite root extracts [115]. Evidence-Based Complementary and Alternative Medicine They found 10 metabolites and 24 parent components and suggested that metabolomic approaches may prove useful in exploring the eﬃcacy of CHM. Moreover, Yan et al. investigated the antiaging eﬀect of ﬂavones contained in Epimedium extract in rats through LC-MS [116]. They were able to identify diﬀerences in multiple changed age- related metabolites in serum, including carnosine, ergoth- ioneine, unsaturated fatty acids, saturated fatty acids, and nucleotides. The expression levels of these age-related pro- teins were restored to levels found in younger rats after Epimedium treatment. Terpenoids, a group of important secondary metabolites in plants, are found in Ganoderma sp., which have high cytotoxic and anti-tumor activity. Ganoderiol F, a tetracyclic triterpene, has been analyzed by LC/MS/MS and adminis- tered to rats for metabolomics and pharmacokinetics exper- iments [117]. Analysis of the metabolites of ganoderiol F by HPLC/MS/MS from orally or i.v.-treated rats showed good viability and low acute toxicity. According to these reports, ganoderiol F may show potential as an anti-cancer drug. 8. Summary and Future Perspectives In this paper, we described and discussed omics research to date combined with acupuncture or CHM, performed at the systems biology level. We found that the ST36 acupoint is the most widely used acupoints, and that it has multiple therapeutic functions and targets, including spinal cord injury [46], allergic rhinitis [56], analgesia [38], neuropathic pain [9, 47], antiaging [41], knee osteoarthritis [45], and acute ischemic stroke [11]. Diﬀerent from other therapies, acupuncture treatments show variation in the transcriptional proﬁles and perceived eﬀect of their subjects, whether rats [39] or humans [40]. Gao et al. reported that approximately 30% of rats demonstrated no analgesic eﬀects during EA [39]. Similarly, Chae et al. reported that 40% of their participants felt only low analgesic eﬀects during acupuncture, an observation that is more likely caused by genetic variation rather than diﬀerences in psychology [40]. Individual variance in treatment response is becoming an important issue when deciding whether it is suitable or not to administer acupuncture therapy. Based on this paper results, we suggest that system biology approaches can be performed to construct exhaustive clinical data of patients with acupuncture or CHM treatments, for example, up- regulated or down-regulated genes of Ph (+) or Ph (−) allergic rhinitis patients with acupuncture treatments, and provide useful information for improving future therapeutic strategies. In term of acupuncture treatment, one acupoint commonly used for diﬀerent symptoms, for example, LI4 acupoint could be performed for allergic rhinitis, analgesia, and acute ischemic stroke. Compared with acupuncture treatments, Chinese herbal treatments are more often inves- tigated for their eﬀectiveness on speciﬁc diseases, and studies focus on the pharmacological mechanisms of diﬀerent herbal extracts, for example, benzodixoloquinolizine alkaloids has anti-tumor activity [77] or CK has anti-diabetic eﬃcacy [21]. In summary, we suggest appropriate therapies—whether