Cotter and O’Keefe Ekbom KA. 1945. Restless legs: a clinical study. Acta Medica Scand Suppl, 158:1-6 Ekbom KA. 1960. Restless legs syndrome. Neurology, 10:868-73. Erikson KM, Jones BC, Hess EJ, et al. 2003. Iron deficiency decreases dopamine D1 and D2 receptors in rat brain. Pharmacol Biochem Behav, 69:409-18. Garcia-Borreguero D, Odin P, Serrano C. 2003. Restless legs syndrome and PD: a review of the evidence for a possible association. Neurology, 61(Suppl 3):S49-55. Garcia-Borreguero D, Larrosa O, de la Llave Y, et al. 2002. Treatment of restless legs syndrome with gabapentin: a double-blind, cross-over study. Neurology, 59:1573-9. Gemignani F, Marbani A, Di Giovanni G, et al. 1999. Charcoy-Marie- Tooth disease type 2 with restless legs syndrome. Neurology, 52:1064- 6. Gudbjornsson B, Broman JE, Hetta J, et al. 1993. Sleep disturbances in patients with primary Sjogren’s syndrome. Br J Rheumatol, 32:1072-6. Hening W, Walters AS, Allen RP, et al. 2004. Impact, diagnosis and treatment of restless legs syndrome (RLS) in a primary care population: the REST (RLS epidemiology, symptoms, and treatment) primary care study. Sleep Med, 5:237-46. Högl B, Kiechl S, Willeit J, et al. 2005. Restless legs syndrome: a community-based study of prevalence, severity, and risk factors. Neurology, 64:1920-4. Kanter AH. 1995. The effect of sclerotherapy on restless legs syndrome. Dermatol Surg, 21:328-32. Kim J, Choi C, Shin K, et al. 2005. Prevalence of restless legs syndrome and associated factors in the Korean adult population: the Korean Health and Genome Study. Psychiatry Clin Neurosci, 59:350-3. Kotagal S, Silber MH. 2004. Childhood-onset restless legs syndrome. Ann Neurol, 56:803-7. Lavigne GJ, Montplaisir JY. 1994. Restless legs syndrome and sleep bruxism: prevalence and association among Canadians. Sleep, 17:739- 43. Lee KA, Zaffke ME, Baratte-Beebe K. 2001. Restless legs syndrome and sleep disturbance during pregnancy: the role of folate and iron. J Womens Health Gend Based Med, 10:335-41. Michaud M, Soucy JP, Chabli A, et al. 2002. SPECT imaging of striatal pre- and postsynaptic dopaminergic status in restless legs syndrome with periodic leg movements in sleep. J Neurol, 249:164-70. Mizuno S, Miyaoka T, Inagaki T, et al. 2005. Prevalence of restless legs syndrome in non-institutionalized Japanese elderly. Psychiatry Clin Neurosci, 59:461-5. Montagna P, Sassoli de Bianchi L, Zucconi M, et al. 1984. Clonazepam and vibration in restless legs syndrome. Acta Neurol Scand, 69:428- 30. Nofzinger EA, Fasiczka A, Berman S, et al. 2000. Bupropion SR reduces periodic limb movements associated with arousals from sleep in depressed patients with periodic limb movement disorder. J Clin Psychiatry, 61:858-62. Nordlander N. 1953. Therapy in restless legs. Acta Med Scand, 45:453-7. Ohayon MM, Roth T. 2002. Prevalence of restless legs syndrome and periodic limb movement disorder in the general population. J Psychosom Res, 53:547-54. O’Keeffe ST, Noel J, Lavan JN. 1993. Restless legs syndrome in the elderly. Postgrad Med J, 69:701-3. O’Keeffe S, Gavin K, Lavan J. 1994. Iron status and restless legs syndrome in the elderly. Age Ageing, 23:200-3. O’Keeffe ST. 2005. Secondary causes of restless legs syndrome in older people. Age Ageing, 34:349-52. Ondo W, Jankovic J. 1996. Restless legs syndrome: clinicoetiologic correlates. Neurology, 47:1435-41. Ondo WG, He Y, Rajasekaran S, Le WD. 2000. Clinical correlates of 6- hydroxydopamine injections into A11 dopaminergic neurons in rats: a possible model for restless legs syndrome. Mov Disord, 15:154-8. Ondo WG, Vuong KD, Jankovic J. 2002. Exploring the relationship between Parkinson disease and restless legs syndrome. Arch Neurol, 59:421-4. Pellecchia MT, Vitale C, Sabatini M, et al. 2004. Ropinirole as a treatment of restless legs syndrome in patients on chronic hemodialysis: an open randomized crossover trial versus levodopa sustained release. Clin Neuropharmacol, 27:178-81. Phillips B, Young T, Finn L, et al. 2000. Epidemiology of restless legs symptoms in adults. Arch Intern Med, 160:2137-41. Picchietti D, Winkelman JW. 2005. Restless legs syndrome, periodic limb movements in sleep, and depression. Sleep, 28:891-8. Pieta J, Millar T, Zacharias J, et al. 1998. Effect of pergolide on restless legs and leg movements in sleep in uremic patients. Sleep, 21:617- 22. Polydekis M, Allen RP, Hauer P, et al. 2000. Subclinical sensory neuropathy in late onset restless legs syndrome. Neurology, 55:1115-21. Ruottinen HM, Partinen M, Hublin C, et al. 2000. An FDOPA PET study in patients with periodic limb movement disorder and restless legs syndrome. Neurology, 54:502-4. Reynolds G, Blake DR, Pall HS, et al. 1986. Restless leg syndrome and rheumatoid arthritis. BMJ, 292:659-60. Rothdach AJ, Trenkwalder C, Haberstock J, et al. 2000. Prevalence and risk factors of RLS in an elderly population: the MEMO study. Memory and Morbidity in Augsburg Elderly. Neurology, 54:1064-8. Saletu M, Anderer P, Saletu-Zyhlarz G, et al. 2001. Restless legs syndrome (RLS) and periodic limb movement disorder (PLMD): acute placebo- controlled sleep laboratory studies with clonazepam. Eur Neuropsychopharmacol, 11:153-61. Salih AM, Gray RE, Mills KR, et al. 1994. A clinical, serological and neurophysiological study of restless legs syndrome in rheumatoid arthritis. Br J Rheumatol, 33:60-3. Sevim S, Dogu O, Camdeviren H, et al. 2003. Unexpectedly low prevalence and unusual characteristics of RLS in Mersin, Turkey. Neurology, 61:1562-9. Shaughnessy P, Lee J, O’Keeffe ST. 2005. Restless legs syndrome in patients with hereditary hemochromatosis. Neurology, 64:2158. Sloand JA, Shelly MA, Feigin A, et al 2004. A double-blind, placebo- controlled trial of intravenous iron dextran therapy in patients with ESRD and restless legs syndrome. Am J Kidney Dis, 43:663-70. Stiasny K, Wetter TC, Trenkwalder C, et al. 2000. Restless legs syndrome and its treatment by dopamine agonists. Parkinsonism Relat Disord, 7:21-5. Telstad W, Sorensen O, Larsen S, et al. 1984. Treatment of the restless legs syndrome with carbamazepine: a double blind study. BMJ, 288:444-6. Thorp ML, Morris CD, Bagby SP. 2001. A crossover study of gabapentin in treatment of restless legs syndrome among hemodialysis patients. Am J Kidney Dis, 38:104-8. Thorpy MJ. 2005. New paradigms in the treatment of restless legs syndrome. Neurology, 64(Suppl 3):S28-33. Tison F, Crochard A, Leger D, et al. 2005. Epidemiology of restless legs syndrome in French adults: a nationwide survey: the INSTANT Study. Neurology, 65:239-46. Trenkwalder C, Garcia-Borreguero D, Montagna P, et al. 2004. Ropinirole in the treatment of restless legs syndrome: results from the TREAT RLS 1 study, a 12 week, randomised, placebo controlled study in 10 European countries. J Neurol Neurosurg Psychiatry, 75:92-7. Trenkwalder C, Seidel VC, Gasser T, et al. 1996. Clinical symptoms and possible anticipation in a large kindred of familial restless legs syndrome. Mov Disord, 4:389-94. Trenkwalder C, Stiasny K, Pollmacher T, et al. 1995. L-dopa therapy of uremic and idiopathic restless legs syndrome: a double-blind, crossover trial. Sleep, 18:681-8. Trenkwalder C, Walters AS, Hening W. 1996. Periodic limb movements and restless legs syndrome. Neurol Clin, 14:629-50. 474 Therapeutics and Clinical Risk Management 2006:2(4)