The Journal of Tehran University Heart Center the syndrome to the offspring.8 The risk of complications during pregnancy is due to the aortic root diameter. The Canadian guidelines recommend that women with an aortic root diameter ≥ 45 mm and the European guidelines recommend that women with an aortic root diameter ≥ 40 mm be discouraged from pregnancy strongly.9, 10 The vaginal delivery is preferable in patients with MFS who have a normal cardiovascular examination and no evidence of aortic dilatation. In these patients, Cesarean section should be reserved for obstetrical indications. Nonetheless, in patients with aortic dilatation or dissection, Cesarean section should be the preferred choice because it minimizes the homodynamic changes associated with vaginal delivery.11 Conclusion It is advisable that not only anyone with MFS by visited by a cardiologist regularly but also all the family members of a patient with MFS be investigated. Furthermore, sufficient information should be provided to parents with MFS on the possibility of transmission to children. References 1. Judge DP, Dietz HC. Marfan’s syndrome. Lancet 2005;366:1965- 1976. 2. Leite Mde F, Aoun NB, Borges MS, Magalhães ME, Christiani LA. Marfan’s syndrome: early and severe form in siblings. Arq Bras Cardiol 2003;81:89-92. 3. Lehmann ED. Cardiovascular screening in Marfan’s syndrome The Lancet 1995;345:1501-1502. 4. Ammash NM , Sundt TM, Connolly HM. Marfan syndrome: diagnosis and management. Curr Probl Cardiol 2008;33:7-39. 5. van Karnebeek CD, Naeff MS, Mulder BJ, Hennekam RC, Offringa M. Natural history of cardiovascular manifestations in Marfan syndrome. Arch Dis Child 2001;84:129-137. 6. Ades L; CSANZ Cardiovascular Genetics Working Group. Guidelines for the diagnosis and management of Marfan syndrome. Heart Lung Circ 2007;16:28-30. 7. Milewicz DM, Dietz HC, Miller DC. Treatment of aortic disease in patients with Marfan syndrome. Circulation 2005;111:e150-157. 8. Hager A, Kaemmerer H, Hess J. Comment on pregnancy and aortic root growth in the Marfan syndrome. Eur Heart J 2005;26:2346. 9. Task Force on the Management of Cardiovascular Diseases During Pregnancy of the European Society of Cardiology. Expert consensus document on management of cardiovascular diseases during pregnancy. Eur Heart J 2003;24:761-781. 10. Therrien J, Gatzoulis M, Graham T, Bink-Boelkens M, Connelly M, Niwa K, Mulder BJM, Pyeritz RE, Perloff J, Somerville J, Webb GD. Canadian cardiovascular society consensus conference 2001 update: recommendations for the management of adults with congenital heart disease: part II. Can J Cardiol 2001;17:1029- 1050. 11. Elkayam U, Ostrzega E, Shotan A, Mehra A. Cardiovascular problems in pregnant women with the Marfan syndrome. Ann Intern Med 1995;123:117-122. 40 Mohammad Hossein Davari et al.