Brain-machine interface research Mikhail AL et al. brain-machine interfaces. IEEE Trans Biomed Eng. 2005;53:1164–73, doi: 10.1109/TBME.2006.870235. 40. Fitzsimmons NA, Drake W, Hanson TL, Lebedev MA, Nicolelis MA. Primate reaching cued by multichannel spatiotemporal cortical micro- stimulation. J Neurosci. 2007;27:5593–602, doi: 10.1523/JNEUROSCI. 5297-06.2007. 41. Maravita A, Spence C, Driver J. Multisensory integration and the body schema: close to hand and within reach. Curr Biol. 2003;13:R531–9, doi: 10.1016/S0960-9822(03)00449-4. 42. Matthews PB. Proprioceptors and their contribution to somatosensory mapping: complex messages require complex processing. Can J Physiol Pharmacol. 1988;66:430–8, doi: 10.1139/y88-073. 43. Longo MR, Azanon E, Haggard P. More than skin deep: body representa- tion beyond primary somatosensory cortex. Neuropsychologia. 2010;48:655–68, doi: 10.1016/j.neuropsychologia.2009.08.022. 44. Crapse TB, Sommer MA. Corollary discharge across the animal kingdom. Nat Rev. 2008;9:587–600. 45. Bach-y-Rita P. Tactile vision substitution: past and future. Int J Neurosci. 1983;19:29–36, doi: 10.3109/00207458309148643. 46. Bach-y-Rita P, Collins CC, Saunders FA, White B, Scadden L. Vision substitution by tactile image projection. Nature. 1969;221:963–4, doi: 10. 1038/221963a0. 47. Bach-y-Rita P, Kercel W. Sensory substitution and the human-machine interface. Trends Cogn Sci. 2003;7:541–6, doi: 10.1016/j.tics.2003.10.013. 48. Histed MH, Bonin V, Reid RC. Direct activation of sparse, distributed populations of cortical neurons by electrical microstimulation. Neuron. 2009;63:508–22, doi: 10.1016/j.neuron.2009.07.016. 49. Rolston JD, Gross RE, Potter SM. A low-cost multielectrode system for data acquisition enabling real-time closed-loop processing with rapid recovery from stimulation artifacts. Front Neuroeng. 2009;2:12, doi: 10. 3389/neuro.16.012.2009. 50. Butovas S, Schwarz C. Spatiotemporal effects of microstimulation in rat neocortex: a parametric study using multielectrode recordings. J Neurophysiol. 2003;90:3024–39, doi: 10.1152/jn.00245.2003. 51. Zhang F, Aravanis AM, Adamantidis A, de Lecea L, Deisseroth K. Circuit-breakers: optical technologies for probing neural signals and systems. Nat Rev. 2007;8:577–81, doi: 10.1038/nrn2192. 52. Boyden ES, Zhang F, Bamberg E, Nagel G, Deisseroth K. Millisecond- timescale, genetically targeted optical control of neural activity. Nat Neurosci. 2005;8:1263–8, doi: 10.1038/nn1525. 53. Zhang F, Wang LP, Boyden ES, Deisseroth K. Channelrhodopsin-2 and optical control of excitable cells. Nat Methods. 2006;3:785–92, doi: 10. 1038/nmeth936. 54. Carson RG. Neural pathways mediating bilateral interactions between the upper limbs. Brain Res. 2005;49:641–62, doi: 10.1016/j.brainresrev. 2005.03.005. 55. Kazennikov O, Hyland B, Corboz M, Babalian A, Rouiller EM, Wiesendanger M. Neural activity of supplementary and primary motor areas in monkeys and its relation to bimanual and unimanual movement sequences. Neuroscience. 1999;89:661–74, doi: 10.1016/S0306-4522(98)- 00348-0. 56. Nakajima T, Mushiake H, Inui T, Tanji J. Decoding higher-order motor information from primate non-primary motor cortices. Technol Health Care. 2007;15:103–10. 57. Obhi SS, Goodale MA. Bimanual interference in rapid discrete move- ments is task specific and occurs at multiple levels of processing. J Neurophysiol. 2005;94:1861–8, doi: 10.1152/jn.00320.2005. 58. Rokni U, Steinberg O, Vaadia E, Sompolinsky H. Cortical representation of bimanual movements. J Neurosci. 2003;23:11577–86. 59. Rouiller EM, Babalian A, Kazennikov O, Moret V, Yu XH, Wiesendanger M. Transcallosal connections of the distal forelimb representations of the primary and supplementary motor cortical areas in macaque monkeys. Exp Brain Res. 1994;102:227–43, doi: 10.1007/BF00227511. 60. Kermadi I, Liu Y, Rouiller EM. Do bimanual motor actions involve the dorsal premotor (PMd), cingulate (CMA) and posterior parietal (PPC) cortices? Comparison with primary and supplementary motor cortical areas. Somatosens Mot Res. 2000;17:255–71, doi: 10.1080/08990220050117619. 61. Pfurtscheller G, Leeb R, Keinrath C, Friedman D, Neuper C, Guger C, et al. Walking from thought. Brain Res. 2006;1071:145–52, doi: 10.1016/j. brainres.2005.11.083. 62. Prilutsky BI, Sirota MG, Gregor RJ, Beloozerova IN. Quantification of motor cortex activity and full-body biomechanics during unconstrained locomotion. J Neurophysiol. 2005;94:2959–69, doi: 10.1152/jn.00704.2004. CLINICS 2011;66(S1):25-32 63. Dietz V. Spinal cord lesion: effects of and perspectives for treatment. Neural Plasticity. 2001;8:83–90, doi: 10.1155/NP.2001.83. 64. Rossignol S, Schwab M, Schwartz M, Fehlings MG. Spinal cord injury: time to move? J Neurosci. 2007;27:11782–92, doi: 10.1523/JNEUROSCI. 3444-07.2007. 65. Scivoletto G, Di Donna V. Prediction of walking recovery after spinal cord injury. Brain Res Bull. 2009;78:43–51, doi: 10.1016/j.brainresbull. 2008.06.002. 66. Boonstra TA, van der Kooij H, Munneke M, Bloem BR. Gait disorders and balance disturbances in Parkinson’s disease: clinical update and pathophysiology. Curr Opin Neurol. 2008;21:461–71, doi: 10.1097/WCO. 0b013e328305bdaf. 67. Pearson OR, Busse ME, van Deursen RW, Wiles CM. Quantification of walking mobility in neurological disorders. QJM. 2004;97:463–75, doi: 10. 1093/qjmed/hch084. 68. Pasquina PF, Bryant PR, Huang ME, Roberts TL, Nelson VS, Flood KM. Advances in amputee care. Arch Phys Med Rehabil. 2006;87(Suppl 1): S34–43, doi: 10.1016/j.apmr.2005.11.026. 69. Anderson KD. Targeting recovery: priorities of the spinal cord-injured population. J Neurotrauma. 2004;21:1371–83, doi: 10.1089/neu.2004.21. 1371. 70. Brown-Triolo DL, Roach MJ, Nelson K, Triolo RJ. Consumer perspectives on mobility: implications for neuroprosthesis design. J Rehabil Res Develop. 2002;39:659–69. 71. Peikon ID, Fitzsimmons NA, Lebedev MA, Nicolelis MA. Three- dimensional, automated, real-time video system for tracking limb motion in brain-machine interface studies. J Neurosci Methods. 2009;180:224–33, doi: 10.1016/j.jneumeth.2009.03.010. 72. Haykin S. Adaptive Filter Theory. 4th ed. Upper Saddle River, NJ: Prentice Hall; 2002. 73. Colombo G, Joerg M, Schreier R, Dietz V. Treadmill training of paraplegic patients using a robotic orthosis. J Rehabil Res Develop. 2000;37:693–700. 74. Dollar AM, Herr H. Lower Extremity Exoskeletons and Active Orthoses: Challenges and State-of-the-Art. IEEE Trans Robotics. 2008;24:144–58, doi: 10.1109/TRO.2008.915453. 75. Ferris DP, Sawicki GS, Daley MA. A Physiologist’s Perspective on Robotic Exoskeletons for Human Locomotion. Int J HR. 2007;4:507–28. 76. Barbeau H, Ladouceur M, Mirbagheri MM, Kearney RE. The effect of locomotor training combined with functional electrical stimulation in chronic spinal cord injured subjects: walking and reflex studies. Brain Res. 2002;40:274–91, doi: 10.1016/S0165-0173(02)00210-2. 77. Dobkin BH. Brain-computer interface technology as a tool to augment plasticity and outcomes for neurological rehabilitation. J Physiol. 2007;579:637–42, doi: 10.1113/jphysiol.2006.123067. 78. Peckham PH, Keith MW, Freehafer AA. Restoration of functional control by electrical stimulation in the upper extremity of the quadriplegic patient. J Bone Joint Surg. 1988;70:144–8. 79. Thrasher TA, Popovic MR. Functional electrical stimulation of walking: function, exercise and rehabilitation. Ann Readapt Med Phys. 2008;51:452–60. 80. Kantrowitz A. A Report of the Maimonides Hospital. Electronic Physiologic Aids. Brooklyn, NY; 1960. 81. Liberson WT, Holmquest HJ, Scot D, Dow M. Functional electrotherapy: stimulation of the peroneal nerve synchronized with the swing phase of the gait of hemiplegic patients. Arch Phys Med Rehabil. 1961;42:101–5. 82. Taylor PN, Burridge JH, Dunkerley AL, Wood DE, Norton JA, Singleton C, et al. Clinical use of the Odstock dropped foot stimulator: its effect on the speed and effort of walking. Arch Phys Med Rehabil. 1999;80:1577– 83, doi: 10.1016/S0003-9993(99)90333-7. 83. Waters RL, McNeal D, Perry J. Experimental correction of footdrop by electrical stimulation of the peroneal nerve. J Bone Joint Surg. 1975;57:1047–54. 84. Graupe D. An overview of the state of the art of noninvasive FES for independent ambulation by thoracic level paraplegics. Neurol Res. 2002;24:431–42, doi: 10.1179/016164102101200302. 85. Graupe D, Kohn KH. Transcutaneous functional neuromuscular stimu- lation of certain traumatic complete thoracic paraplegics for independent short-distance ambulation. Neurol Res. 1997;19:323–33. 86. Cheng G, Hyon SH, Morimoto J, Ude A, Hale JG, Colvin G, et al. CB: A humanoid research platform for exploring neuroscience. Adv Robotics. 2007;21:1097–14, doi: 10.1163/156855307781389356. 32