Appetecchia and Baldelli Journal of Experimental & Clinical Cancer Research 2010, 29:19 http://www.jeccr.com/content/29/1/19 Page 11 of 12 46. Appetecchia M, Ferretti E, Carducci M, Izzo F, Carpanese L, Marandino F, Terzoli E: Malignant glucagonoma. New options of treatment. J Exp Clin Cancer Res 2006, 25:135-9. 47. Soga J, Yakuwa Y: Somatostatinoma/inhibitory syndrome: a statistical evaluation of 173 reported cases as compared to other pancreatic endocrinomas. J Exp Clin Cancer Res 1999, 18:13-22. 48. Angeletti S, Corleto VD, Schillaci O, Marignani M, Annibale B, Moretti A, Silecchia G, Scopinaro F, Basso N, Bordi C, Delle Fave G: Use of the somatostatin analogue octreotide to localise and manage somatostatin- producing tumours. Gut 1998, 42:792-794. 49. Ghaferi AA, Chojnacki KA, Long WD, Cameron JL, Yeo CJ: Pancreatic VIPomas: subject review and one institutional experience. J Gastrointest Surg 2007, 12:382-93. 50. Song S, Shi R, Li B, Liu Y: Diagnosis and Treatment of Pancreatic Vasoactive Intestinal Peptide Endocrine Tumors. Pancreas 2009, 38(7):811-4. 51. Nakayama S, Yokote T, Kobayashi K, Hirata Y, Hiraiwa T, Komoto I, Miyakoshi K, Yamakawa Y, Takubo T, Tsuji M, Imamura M, Hanafusa T: VIPoma with expression of both VIP and VPAC1 receptors in a patient with WDHA syndrome. Endocrine 2009, 35:143-6. 52. Schally AV: Oncological applications of somatostatin analogues. Cancer Res 1988, 48:6977-6985. 53. Pollak MN, Schally AV: Mechanisms of antineoplastic action of somatostatin analogs. Proc Soc Exp Biol Med 1998, 217:143-152. 54. Weckbecker G, Raulf F, Stolz B, Bruns C: Somatostatin analogs for diagnosis and treatment of cancer. Pharmacol Ther 1993, 60:245-264. 55. Froidevaux S, Eberle AN: Somatostatin analogs and radiopeptides in cancer therapy. Biopolymers 2002, 66:161-183. 56. Schally AV, Nagy A: Chemotherapy targeted to cancers through tumoral hormone receptors. Trends Endocrinol Metab 2004, 15:300-310. 57. Pyronnet S, Bousquet C, Najib S, Azar R, Laklai H, Susini C: Antitumor effects of somatostatin. Mol Cell Endocrinol 2008, 286:230-7. 58. Jensen RT: Carcinoid and pancreatic endocrine tumors: recent advances in molecular pathogenesis, localization, and treatment. Current Opinion in Oncology 2000, 12:368-377. 59. Reubi JC: A somatostatin analogue inhibits chondrosarcoma and insulinoma tumour growth. Acta Endocrinol (Copenh) 1985, 109:108-114. 60. Scarpignato C, Pelosini I: Somatostatin analogs for cancer treatment and diagnosis: an overview. Chemotherapy 2001, 47:1-29. 61. Imam H, Eriksson B, Lukinius A, Janson ET, Lindgren PG, Wilander E, Oberg K: Induction of apoptosis in neuroendocrine tumors of the digestive system during treatment with somatostatin analogs. Acta Oncol 1997, 36:607-614. 62. Eriksson B, Renstrup J, Imam H, Oberg K: High-dose treatment with lanreotide of patients with advanced neuroendocrine gastrointestinal tumors: clinical and biological effects. Ann Oncol 1997, 8:1041-1044. 63. Faiss S, Räth U, Mansmann U, Caird D, Clemens N, Riecken EO, Wiedenmann B: Ultra-high-dose lanreotide treatment in patients with metastatic neuroendocrine gastroenteropancreatic tumors. Digestion 1999, 60:469-476. 64. Lawnicka H, Stepieñ H, Wyczółkowska J, Kolago B, Kunert-Radek J, Komorowski J: Effect of somatostatin and octreotide on proliferation and vascular endothelial growth factor secretion from murine endothelial cell line (HECa10) culture. Biochem Biophys Res Commun 2000, 268:567-571. 65. Treiber G, Wex T, Röcken C, Fostitsch P, Malfertheiner P: Impact of biomarkers on disease survival and progression in patients treated with octreotide for advanced hepatocellular carcinoma. J Cancer Res Clin Oncol 2006, 132:699-708. 66. Dimitroulopoulos D, Xinopoulos D, Tsamakidis K, Zisimopoulos A, Andriotis E, Panagiotakos D, Fotopoulou A, Chrysohoou C, Bazinis A, Daskalopoulou D, Paraskevas E: Long acting octreotide in the treatment of advanced hepatocellular cancer and overexpression of somatostatin receptors: randomized placebo-controlled trial. World J Gastroenterol 2007, 13:3164-3170. 67. Lamberts SW, Krenning EP, Reubi JC: The role of somatostatin and its analogs in the diagnosis and treatment of tumors. Endocr Rev 1991, 12:450-482. 68. Bousquet C, Puente E, Buscail L, Vaysse N, Susini C: Antiproliferative effect of somatostatin and analogs. Chemotherapy 2001, 47:30-39. 69. Danesi R, Agen C, Benelli U, Paolo AD, Nardini D, Bocci G, Basolo F, Campagni A, Tacca MD: Inhibition of experimental angiogenesis by the somatostatin analogue octreotide acetate (SMS 201-995). Clin Cancer Res 1997, 3:265-272. 70. Woltering EA, Watson JC, Alperin-Lea RC, Sharma C, Keenan E, Kurozawa D, Barrie R: Somatostatin analogs: angiogenesis inhibitors with novel mechanisms of action. Invest New Drugs 1997, 15:77-86. 71. Anthony L, Johnson D, Hande K, Shaff M, Winn S, Krozely M, Oates J: Somatostatin analogue phase I trials in neuroendocrine neoplasms. Acta Oncol 1993, 32:217-223. 72. Kvols LK, Woltering EA: Role of somatostatin analogs in the clinical management of non-neuroendocrine solid tumors. Anticancer Drugs 2006, 17:601-608. 73. Arnold R, Benning R, Neuhaus C, Rolwage M, Trautmann ME: Gastroenteropancreatic endocrine tumours: effect of Sandostatin on tumour growth. The German Sandostatin Study Group. Digestion 1993, 54:72-75. 74. Arnold R, Trautmann ME, Creutzfeldt W, Benning R, Benning M, Neuhaus C, Jürgensen R, Stein K, Schäfer H, Bruns C, Dennler HJ: Somatostatin analogue octreotide and inhibition of tumour growth in metastatic endocrine gastroenteropancreatic tumours. Gut 1996, 38:430-438. 75. Saltz L, Trochanowski B, Buckley M, Heffernan B, Niedzwiecki D, Tao Y, Kelsen D: Octreotide as an antineoplastic agent in the treatment of functional and nonfunctional neuroendocrine tumors. Cancer 1993, 72:244-248. 76. Panzuto F, Di Fonzo M, Iannicelli E, Sciuto R, Maini CL, Capurso G, Milione M, Cattaruzza MS, Falconi M, David V, Ziparo V, Pederzoli P, Bordi C, Delle Fave G: Long-term clinical outcome of somatostatin analogues for treatment of progressive, metastatic, well-differentiated entero- pancreatic endocrine carcinoma. Ann Oncol 2006, 17:461-466. 77. Faiss S, Scherübl H, Riecken EO, Wiedenmann B: Drug therapy in metastatic neuroendocrine tumors of the gastroenteropancreatic system. Recent Results Cancer Res 1996, 142:193-207. 78. Welin SV, Janson ET, Sundin A, Stridsberg M, Lavenius E, Granberg D, Skogseid B, Oberg KE, Eriksson BK: High-dose treatment with a long- acting somatostatin analogue in patients with advanced midgut carcinoid tumours. Eur J Endocrinol 2004, 151:107-112. 79. Arnold R, Rinke A, Klose KJ, Müller HH, Wied M, Zamzow K, Schmidt C, Schade-Brittinger C, Barth P, Moll R, Koller M, Unterhalt M, Hiddemann W, Schmidt-Lauber M, Pavel M, Arnold CN: Octreotide versus octreotide plus interferon-alpha in endocrine gastroenteropancreatic tumors: a randomized trial. Clin Gastroenterol Hepatol 2005, 3:761-771. 80. Rinke A, Müller HH, Schade-Brittinger C, Klose KJ, Barth P, Wied M, Mayer C, Aminossadati B, Pape UF, Bläker M, Harder J, Arnold C, Gress T, Arnold R, PROMID Study Group: Placebo-Controlled, Double-Blind, Prospective, Randomized Study on the Effect of Octreotide LAR in the Control of Tumor Growth in Patients With Metastatic Neuroendocrine Midgut Tumors: A Report From the PROMID Study Group. J Clin Oncol 2009, 27:4656-63. 81. Shojamanesh H, Gibril F, Louie A, Ojeaburu JV, Bashir S, Abou-Saif A, Jensen RT: Prospective study of the antitumor efficacy of long-term octreotide treatment in patients with progressive metastatic gastrinoma. Cancer 2002, 94:331-343. 82. Prommegger R, Bale R, Ensinger C, Sauper T, Profanter C, Knoflach M, Moncayo R: Gastric carcinoid type I tumour: new diagnostic and therapeutic method. Eur J Gastroenterol Hepatol 2003, 15:705-707. 83. Fykse V, Sandvik AK, Qvigstad G, Falkmer SE, Syversen U, Waldum HL: Treatment of ECL cell carcinoids with octreotide LAR. Scand J Gastroenterol 2004, 39:621-628. 84. Dworakowska D, Wlodek E, Leontiou C, Igreja S, Cakir M, Teng M, Prodromou N, Goth M, Grozinsky-Glasberg S, Gueorguiev M, Kola B, Korbonits M, Grossman A: Activation of Raf/MEK/ERK and PI3K/Akt/mTOR pathways in pituitary adenomas and their effects on downstream effectors. Endocr Relat Cancer 2009, 16(4):1329-38. 85. Romeo S, Milione M, Gatti A, Fallarino M, Corleto V, Morano S, Baroni MG: Complete clinical remission and disappearance of liver metastases after treatment with somatostatin analogue in a 40-year-old woman with a malignant insulinoma positive for somatostatin receptors type 2. Hormone Research 2006, 65:120-125.