Zhang et al. Journal of Experimental & Clinical Cancer Research 2010, 29:88 http://www.jeccr.com/content/29/1/88 43. Hemavathy K, Ashraf SI, Ip YT: Snail/slug family of repressors: slowly going into the fast lane of development and cancer. Gene (Amst.) 2000, 257:1-12. 44. Thiery JP: Epithelial-mesenchymal transitions in tumor progression. Nat Rev Cancer 2002, 2:442-454. 45. Barrett K, Leptin M, Settleman J: The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation. Cell 1991, 91:905-915. 46. Liu JP, Jessell TM: A role for rhoB in the delamination of neural crest cells from the dorsal neural tube. Development (Camb.) 1998, 125:5055-5067. doi:10.1186/1756-9966-29-88 Cite this article as: Zhang et al.: The E-cadherin repressor slug and progression of human extrahepatic hilar cholangiocarcinoma. Journal of Experimental & Clinical Cancer Research 2010 29:88. Page 10 of 10 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color ﬁgure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit