Association of ADH1B and ALDH2 gene polymorphisms with alcohol dependence RESEARCH uniquely high frequency of the ALDH2*2/*2 gen- otype (among alcohol-dependent subjects) being a risk-conferring factor for AD. Further, based on the ﬁndings from this study, albeit based on a limited sample size, it could be hypothesised that the Indian genotype is prone to slow metabolism of alcohol and high metabolism of acetaldehyde, and thereby prone to alcoholism. Our ﬁndings should be viewed, however, in the perspective of the potential limitation posed by the absence of data from an eth- nically, age- and sex-matched control population. Further, these results not only warrant replication in larger sample sets, but also underscore the need for investigations on candidate gene polymorphisms from other biochemical pathways. 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