Wound healing effects of Arnebia densiflora control group. Incision region was not healed and in some animals, it was observed that mucosal closure was completed; however, submucosal closure was not. It was observed that epithelial and subepithelial regions of incision area were closed in animals treated with A. densiolfra root extract for four days. The collagen production was in reticular fiber stage but was not completed. Mononuclear cell infiltration was present. In the experimental group, rapid improvement was determined comparing with the control group (Figure 1). In the control group, wound was exactly closed after 7 days; collagen production was in reticular fiber stage and in this region, mononuclear cell infiltration was present. The collagen fibers were prominently observed in wound regions treated with extract for 7 days. Epithelial hyperplasia was Figure 2. Seven days after scalpel incision (I), both epithelium (E) and subepithelium (S) regions seem to be healed in untreated (a) and A. densiflora treated (b) groups. Epidermal hyperplasia (H) is also evident in the A. densiflora treated group. a: HEx20, b: HEx10. Figure 3. Shows epithelium (E) and subepithelium (S) regions 14 days after scalpel incisions (I). a: untreated, b: A. densiflora treated group. a, b: HEx10. Figure 4. Epithelium (E) and subepithelium (S) regions of untreated (a) and A. densiflora treated (b) groups 21 days after scalpel incisions (I). a, b: HEx10. 98 European Journal of Dentistry