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(2010) 4, 1: 19–28. doi: 10.3389/neuro.01.013.2010 Copyright © 2010 Brigman, Graybeal and Holmes. This is an open-access publica- tion subject to an exclusive license agree- ment between the authors and the Frontiers Research Foundation, which permits unre- stricted use, distribution, and reproduc- tion in any medium, provided the original authors and source are credited. www.frontiersin.org