168 Groups Fever Fever and Muscle pain Fever, muscle And joint pain Nt means not tested. Breed, years/sex(m,f) Bearded collie 1/f German shepherd,1/m German shorthaired pointer,1/m Large poodle 13/m Breton 3/f English setter 2/m English setter 2/m Flatcoated retriev.9/f Flatcoated retriev.1/f German shepherd 6/f German shorthaired pointer,7/m Irish setter,1/f Irish wolf hound, 9/m Irish wolf hound, 2/? Kleiner Münsterl. 5/f Schiller dog 1/m Berner Sennen, 7/f Border collie, 1/m Irish setter, 1/f Schiller dog, 1/f + - - + - + + + - - - - - - - - + + - - J. Øvrebø Bohnhorst et al. Ta bl e 1 . Antinuclear antibodies (ANA), antibodies against extractable nuclear antigens (anti ENA), rheuma- toid factor (RF), and of interleukin-6 (IL-6) in serum from dogs with imune-mediated fever. Anti ENA ANA RF Il-6 pg/ml ﬁrst time a few days after parvo virus vaccina- tion. Clinical signs that could be related to ca- nine leucocyte adhesion deﬁciency (Trowald- Wigh et al. 2000) were not observed. The same happened to a 4 months old male German short-haired pointer, but he restituted completely after one prednisolone cure. He was vaccinated later on and after 2 years he has still not shown any relapses. No triggering event or reason could be revealed for the other patients, and none of them has presented signs later on related to this history. The results of the ANA, anti ENA, RF and IL- 6 analyses are presented in Table 1. Seven out of 20 patients were ANA positive, 1 out of 20 was anti ENA positive on both tests, 2 Acta vet. scand. vol. 43 no. 3, 2002 out of 13 was RF positive and 10 out of 13 pa- tients presented elevated Il-6 values. In the fever group (4 dogs) 1 bearded collie and 1 large poodle were ANA positive. The poodle showed elevated IL-6 level, while the other did not. One out of 2 ANA negative German shep- herds presented elevated IL-6 level, and the other did not. In the fever and muscle pain group (12 dogs) 2 English setters and 1 ﬂatcoated retriever tested positive for ANA, and 1 breton and 1 German shepherd were RF positive. Only the German shepherd was tested for IL-6 and she was nor- mal. Another 5 dogs in this group were tested for IL-6, and all of them showed elevated IL-6 values: a 7 year old male German short-haired - - - - - - - - - - - - - - - - + - - - - - nt nt + - nt - nt + - nt nt nt - - - - - - <25 653 <25 478 nt nt nt nt 6280 <25 396 578 nt nt 8265 1033 nt 880 >12500 5288