CLINICS 2012;67(S1):29-32 presented with gigantism, acromegaly, or prolactinoma have the same mutation and haplotype associated with the mutated gene. Using coalescent theory, they came to the conclusion that these persons share a common ancestor who lived about 57–66 generations earlier (69). Familial acromegaly and gigantism only account for a very tiny proportion of all pituitary adenomas and can be related to MEN 1 and CNC syndromes as well as to mutations in the AIP gene. AIP mutations are very common in gigantism. REFERENCES 1. Marie P. Sur deux cas d’acrome´galie: hypertrophie singulie`re non conge´nitale des extre´mite´s supe´rieures, infe´rieures et ce´phalique. Rev Me´d Liege. 1886;6:297–333. 2. Verga A. Caso singolare de prosopectasia. Reale Istituto Lombardo di Scienze e Lettere Bendiconti Classe di Scienze Matematiche e Naturali. 1864;1:111–17. 3. Brigidi V. Studii anatomopatologica sopra un uomo divenuto strana- mente deforme per chronica infirmita. 1877. 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