Genetics of Interleukin 1 Receptor-Like 1 in Immune Current Genomics, 2010, Vol. 11, No. 8 599 Gene SNP Chr. Loc. SNP Location Disease/Phenotype pValue Study Population N IL18R1 rs3771166 102986222 intronic Childhood asthma 0.011 IL18R1 rs1974675 102986375 intronic Asthma / Atopic asthma / BHR 0.00005 / 0.00001 / 0.036 IL18R1 rs1465321 102986618 intronic Humoral immunity to Rubella 0.009 Candidate gene study Somali IL18R1 rs2287037 102979028 5' near-gene Asthma 0.024 IL18R1 rs1420099 102980543 intronic Asthma / Atopic asthma 0.00069 / 0.00008 Candidate gene study IL18R1 rs1420098 102984279 intronic Asthma 0.037 IL18R1 rs1362348 102984624 intronic Asthma / Atopic asthma / BHR 0.0013 / 0.00024 / 0.048 IL18R1 rs1558627 102984684 intronic BHR / Total IgE 0.049/.028 IL18R1 rs2058622 102985424 intronic Atopic asthma 0.045 IL18R1 rs3771170 102985980 intronic Humoral immunity to Rubella 0.0003 Candidate gene study Somali Candidate gene study Candidate gene study Candidate gene study European (Danish, British, Norwegian) 736 families European (Danish, British, Norwegian) 736 families European (Danish, British, Norwegian) 736 families European (Danish, British, Norwegian) 736 families Candidate gene study Dutch 180 / 238 families Candidate gene study European (Danish, British, Norwegian) 736 families Candidate gene study_follow-up to GWAS Candidate gene study Mexican European (Danish, British, Nor- wegian) (Table 1). Contd….. Refs. Zhu et al. - Eur J Hum Genet 2008 Zhu et al. - Eur J Hum Genet 2008 Zhu et al. - Eur J Hum Genet 2008 Zhu et al. - Eur J Hum Genet 2008 Reijmer- ink et al. - J Al- lergy Clin Immunol 2008 Zhu et al. - Eur J Hum Genet 2008 Dhiman et al. - Tissue 89 individu- Antigens als 2008 Wu et al. - J Al- lergy Clin 492 cases + Immunol both parents 2010 Zhu et al. - Eur J Hum Genet 2008 736 families Dhiman et al. - Tissue 89 individu- Antigens als 2008