Jin et al. Journal of Experimental & Clinical Cancer Research 2010, 29:18 http://www.jeccr.com/content/29/1/18 Page 5 of 8 Figure 2 Forest plot of the RE ORs and 95% CIs of the studies on the association between HCC and the HFE C282Y mutation (Y vs. C) of seven studies (using healthy controls). Figure 3 Forest plot of the FE ORs and 95% CIs of the studies on the association between HCC and the HFE C282Y mutation (YY+CY Vs. CC) of four studies (using alcoholic LC controls). derived FPRP to assess the reliability of the association. OR of allele contrast (Y vs. C) equaled 3.41 (95%CI: 1.81-6.41) in the subgroup analysis of four studies using alcoholic LC controls. If the prior probability of devel- oping HCC in alcoholic LC patients is assigned at 0.01, then FPRP was 0.03 (<0.20). Given that mutation allele Y of C282Y is a risk factor of HCC, we further calculated PAR and its’ 95%CI in all populations and in alcoholic LC patients. According to the formula from Bruzzi, PAR of allele Y is 2.48% (95% CI: 1.30%-3.65%) and 5.12% (2.57%-7.67%) in all popula- tions and in alcoholic LC patients, respectively.