Decompensated Bladder Following Bladder Outlet Obstruction were stabilized [5]. From the earlier phase, the bladders ex- hibited serial changes in pressure parameters from the fill- ing to the voiding phase. There were no changes in bladder capacity during the earlier phase, although the bladders showed increased residual volume and decreased mictur- ition volume/compliance. We also confirmed that decom- pensated bladders in view of residual urine could be seen from the earlier phase, and during the later phase, there was an increased tendency for compensated bladders, which were accompanied by the bladders being enlarged and more compliant. Conflicts of Interest The authors have nothing to disclose. REFERENCES 1. Berry SJ, Coffey DS, Walsh PC, Ewing LL. The development of human benign prostatic hyperplasia with age. J Urol 1984;132: 474-9. 2. Roberts RO, Jacobsen SJ, Jacobson DJ, Rhodes T, Girman CJ, Lieber MM. Longitudinal changes in peak urinary flow rates in a community based cohort. J Urol 2000;163:107-13. 3. Chute CG, Panser LA, Girman CJ, Oesterling JE, Guess HA, Jacobsen SJ, et al. The prevalence of prostatism: a pop- ulation-based survey of urinary symptoms. J Urol 1993;150:85-9. 4. Cuellar DC, Kyprianou N. Future concepts in the medical therapy of benign prostatic hyperplasia. Curr Opin Urol 2001;11:27-33. 5. Levin RM, Haugaard N, O'Connor L, Buttyan R, Das A, Dixon JS, et al. Obstructive response of human bladder to BPH vs. rabbit bladder response to partial outlet obstruction: a direct compa- rison. Neurourol Urodyn 2000;19:609-29. 6. Levin RM, Monson FC, Haugaard N, Buttyan R, Hudson A, Roelofs M, et al. Genetic and cellular characteristics of bladder outlet obstruction. Urol Clin North Am 1995;22:263-83. 7. O'Connor LT Jr, Vaughan ED Jr, Felsen D. In vivo cystometric evaluation of progressive bladder outlet obstruction in rats. J Urol 1997;158:631-5. 841 8. Zderic SA, Rohrmann D, Gong C, Snyder HM, Duckett JW, Wein AJ, et al. The decompensated detrusor II: evidence for loss of sarco- plasmic reticulum function after bladder outlet obstruction in the rabbit. J Urol 1996;156:587-92. 9. Levin RM, Longhurst PA, Monson FC, Kato K, Wein AJ. Effect of bladder outlet obstruction on the morphology, physiology, and pharmacology of the bladder. Prostate Suppl 1990;3:9-26. 10. Berggren T, Andersson KE, Lundin S, Uvelius B. Effect and con- tent of arginine vasopressin in normal and obstructed rat urinary bladder: an in vivo and in vitro investigation. J Urol 1993;150: 1540-3. 11. Malmgren A, Sjögren C, Uvelius B, Mattiasson A, Andersson KE, Andersson PO. Cystometrical evaluation of bladder instability in rats with infravesical outflow obstruction. J Urol 1987;137: 1291-4. 12. Lee T, Andersson KE, Streng T, Hedlund P. Simultaneous regis- tration of intraabdominal and intravesical pressures during cyst- ometry in conscious rats--effects of bladder outlet obstruction and intravesical PGE2. Neurourol Urodyn 2008;27:88-95. 13. Jin LH, Andersson KE, Kwon YH, Yoon SM, Lee T. Selection of a control rat for conscious spontaneous hypertensive rats in stud- ies of detrusor overactivity on the basis of measurement of in- tra-abdominal pressures. Neurourol Urodyn 2010;29:1338-43. 14. Levin RM, O'Connor LJ, Leggett RE, Whitbeck C, Chichester P. Focal hypoxia of the obstructed rabbit bladder wall correlates with intermediate decompensation. Neurourol Urodyn 2003;22: 156-63. 15. Schröder A, Chichester P, Kogan BA, Longhurst PA, Lieb J, Das AK, et al. Effect of chronic bladder outlet obstruction on blood flow of the rabbit bladder. J Urol 2001;165:640-6. 16. Finkbeiner A, Lapides J. Effect of distension on blood flow in dog's urinary bladder. Invest Urol 1974;12:210-2. 17. Lieb JI, Chichester P, Kogan B, Das AK, Leggett RE, Schröder A, et al. Rabbit urinary bladder blood flow changes during the ini- tial stage of partial outlet obstruction. J Urol 2000;164:1390-7. 18. Park SH, Jin LH, Kwon YH, Yoon SM, Ryu JK, Lee T. Application and limitations of awake cystometry in Sprague-Dawley Rats with partial bladder outlet obstruction as a model of overactive bladder or obstruction. Korean J Urol 2009;50:486-92. Korean J Urol 2011;52:835-841