Savine R, Sönksen P. 2000. Growth hormone - hormone replacement for the somatopause? Horm Res, 53:37–41. Scaramuzza A, Castellani G, Lorini R. 1996. Insulin abuse in an adolescent with insulindependent diabetes mellitus. Eur J Pediatr, 155:526. Scarlett JA, Mako ME, Rubenstein AH, et al. 1977. Factitious hypoglycemia. Diagnosis by measurement of serum Cpeptide immunoreactivity and insulinbinding antibodies. N Engl J Med, 297:1029–32. Schafer E. 1916. The endocrine organs. London: Longman, Green and Co. Schuelke M, Wagner KR, Stolz LE, et al. 2004. Myostatin mutation associated with gross muscle hypertrophy in a child. N Engl J Med, 350:2682–8. Shahidi NT. 2001. A review of the chemistry, biological action, and clinical applications of anabolic-androgenic steroids. Clin Ther, 23:1355–90. Sinha A, Formica C, Tsalamandris C, et al. 1996. Effects of insulin on body composition in patients with insulin-dependent and non-insulin- dependent diabetes. Diabet Med, 13:40–6. Sonksen PH. 2001. Insulin, growth hormone and sport. J Endocrinol, 170:13–25. Sonksen PH, Sonksen J. 2000. Insulin: Understanding its action in health and disease. Br J Anaesthesia, 85:69–79. Stabler B, Turner JR, Girdler SS, et al. 1992. Reactivity to stress and psychological adjustment in adults with pituitary insufﬁciency. Clin Endocrinol, 6:467–73. Stouthart PJ, Deijen JB, Roffel M, et al. 2003. Quality of life of growth hormone (GH) deﬁcient young adults during discontinuation and restart of GH therapy. Psychoneuroendocrinology, 28:612–26. Taaffe DR, Pruitt L, Reim J, et al. 1994. Effects of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men. J Clin Endocrinol Metab, 79:1361–6. AAS, growth hormone, and insulin abuse Takala J, Ruokonen E, Webster NR, et al. 1999. Increased mortality associated with growth hormone treatment in critically ill adults. N Engl J Med, 341:785–92. Thomas SHL, Wisher MH, Brandenburg D, et al. 1979. Insulin action on adipocytes. Evidence that the anti-lipolytic and lipogenic effects of insulin are medicated by the same receptor. Biochem J, 184:355–60. Wallace JD, Cuneo RC, Baxter R, et al. 1999. Responses of the growth hormone (GH) and insulin-like growth factor axis to exercise, GH administration and GH withdrawal in trained adult males: a potential test for GH abuse in sport. J Clin Endocrinol Metab, 84:3591–601. Weiss RD, Greenﬁeld SF, Najavits LM, et al. 1998. Medication compliance among patients with bipolar disorder and substance use disorder. J Clin Psychiatry, 59:172–4. Wu Z, Bidlingmaier M, Dall R, et al. 1999. Detection of doping with human growth hormone. Lancet, 353:895. Yarasheki KE, Campbell JA, Smith K. 1992. Effect of growth hormone and resistance exercise on muscle growth and strength in young men. Am J Physiol, 262:261–7. Yarasheki KE, Zachwieja JJ, Angelopoulos TJ. 1993. Short-term growth hormone treatment does not increase muscle protein synthesis in expe- rienced weight lifters. J Appl Physiol, 74:3073–6. Yarasheki KE, Zachwieja JJ, Campbell JA, et al. 1995. Effect of growth hormone and resistance exercise on muscle growth and strength in older men. Am J Physiol, 268:268–76. Zachwieja JJ, Yarasheki KE. 1999. Does growth hormone therapy in conjunction with resistance exercise increase muscle force production and muscle mass in men and women aged 60 years or older? Phys Ther, 79:76–82. Zigmond AS, Snaith RP. 1983. The hospital anxiety and depression scale. Acta Psychiatr Scand, 67:361–70. Therapeutics and Clinical Risk Management 2008:4(3) 597