Genetics of Interleukin 1 Receptor-Like 1 in Immune Current Genomics, 2010, Vol. 11, No. 8 603 Gene SNP Chr. Loc. SNP Location Disease/Phenotype pValue Study Population N IL18R1 / IL18RAP 22 candidate SNPs Cardiovascular mortality NS Candidate gene study 142 cases / German 1142 controls tion 2005 - - - - - - IL1RL1 multimarker (11) Childhood asthma 2.2 x 10-4 IL18R1 multimarker (9) Childhood asthma 9 x 10-3 Chromosome 2 Abbreviations IBD Inflammatory bowel disease BHR Bronchial hyper-responsiveness GWAS Genome-wide association study Chr.Loc Chromosal location based on NCBI build 37.1 Chr 2 Haplo Haplotype NS Non significant Cod.non.syn Coding non synonymous SNP Cod.syn Coding synonymous SNP Same SNPs are highlited with the same color; different colors are merely for ease of viewing, and are inconsequential. (Table 1). Contd….. Refs. Tiret et al. - Circula- Wu et al. - J Al- lergy Clin Wu et al. - J Al- lergy Clin Candidate gene study_follow-up to GWAS Candidate gene study_follow-up to GWAS 492 cases + Immunol Mexican both parents 2010 492 cases + Immunol Mexican both parents 2010 IL1RL1; functional characterization of genetically-associated variants is necessary to determine the causal pathways lead- ing to expression and/or function changes in the proteins. As shown by numerous animal model studies, targeting the IL1RL1/IL33 axis is potentially a very promising thera- peutic avenue for lung, heart and other immune and inflam- matory disorders. 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