Ageliki Pandazi, Periandros Karamanis, Paraskevi Matsota, Stella Kontogiannopoulou, Kostantinos Soultanis, Georgia Kostopanagiotou the patient was given enoxaparin 4,000 IU SC. At that time the patient started complaining of severe backache, especially at the site of the ED puncture, and 2 h later he started complaining of emerging motor loss in the lower limbs. Neurological examination of the patient revealed paraplegia with no sensory deficit. The magnetic resonance imaging that was performed showed an epidural haematoma (EH) extending from T10 to L2 and compressing the spinal cord. An emergency laminectomy from T9 to L2 was performed 10 h after the recognition of paraplegia and the EH was evacuated. Over the next 2 months he started recovering motor power in the lower limbs, but never experienced a full recovery, since he died because of sepsis due to an infection of the surgical trauma on his back. The second patient had her ED catheter accidentally removed on the 2nd postoperative day approximately 2 h after the administration of enoxaparin (she received enoxaparin 6,000 IU once daily). Two h later, the neurological examination showed emerging weakness in the left leg and a sensory deficit at the T8-T10 dermatomes (especially on the left). The MRI of the spine that was then performed revealed a posterior EH at the T7-T9 neurotomes with the presence of air on its top and significant compression of the spinal cord. Twelve hours after estimated catheter removal the patient underwent a T6-L1 laminectomy and evacuation of the haematoma. There was minimal improvement in the neurological symptoms in the first 24 h after surgery. Two months after surgery only poor improvement of her symptoms was observed. Discussion Data on the incidence of EH following neuraxial blockade are mainly based on audit studies and case reports [1]. Most case reports describe haematomas that were associated with the placement of an epidural catheter [1, 2]. Predisposing factors for the development of an EH following neuraxial blockade are considered to be pre-existing altered patients’ coagulation due to either an inherent coagulopathy or the administration of anticoagulants, spinal vascular malformations, hypertension, advanced age, female gender, and bony spinal pathology that may necessitate multiple attempts [2, 3]. Both of our patients were under enoxaparin (a low molecular weight heparin [LMWH]) perioperatively. The use of LMWH is associated with an increasing incidence of spinal EH following neuraxial blockade [4]. We complied with the American Society of Regional Anaesthesia and Pain Medicine (ASRA) recommendations for neuraxial anaesthesia and anticoagulation in both of our cases [5]. We assume that the EH in both cases occurred at the time the catheter was removed. As far as the first patient is concerned, it seems that the co- administration of anticoagulants to patients on regular antiplatelet medications may significantly increase the risk of EH [6]. Furthermore, the antiplatelet effect of clopidogrel is irreversible and it is possible that the period of 7 days before neuraxial blockade in our case was inadequate, since it takes up to 10 days for new platelets to completely replace affected ones and Keser has shown that a period of 10 days is necessary for the bleeding time to return to normal values after discontinuing clopidogrel [7]. The haematoma of the second case can be attributed to removal of the catheter during the period of the anticoagulant action of enoxaparin. Advanced age, female gender and orthopaedic operation may have also contributed to haematoma formation. The presence of the haematoma at the T7-T9 neurotomes, despite the fact that the epidural approach was at the L3-L4 interspace, may also raise the question of a spontaneous haematoma coinciding with catheter removal. The early recognition and evacuation of the EH are of major importance for a good outcome. It has been observed that patients who were operated on within 12 h of developing symptoms compared with those operated on later had a better outcome, while other anaesthetists propose an even shorter interval of < 8 h for improving prognosis [3]. The evacuating operation in both of our cases was performed at the latest permitted limits. This fact, in combination with the advanced age and the multiple medical problems of our patients, might have contributed to the bad outcomes. These two cases underscore the necessity of close neurological monitoring in every patient having an ED catheter for postoperative analgesia, especially if anticoagulant treatment is administered. 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