J Mol Hist (2009) 40:177–181 Open Access This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which per- mits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. References Boffetta P, Hashibe M (2006) Alcohol and cancer. Lancet Oncol 7(2):149–156 Bova RJ, Quinn DI, Nankervis JS, Cole IE, Sheridan BF, Jensen MJ, Morgan GJ, Hughes CJ, Sutherland RL (1999) Cyclin D1 and p16INK4A expression predict reduced survival in carcinoma of the anterior tongue. Clin Cancer Res 5(10):2810–2819 Cooper JS, Pajak TF, Forastiere AA, Jacobs J, Campbell BH, Saxman SB, Kish JA, Kim HE, Cmelak AJ, Rotman M, Machtay M, Ensley JF, Chao KS, Schultz CJ, Lee N, Fu KK (2004) Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med 350(19):1937–1944 Eulderink F (1972) Experimental mesenchymal jaw tumors in mice. Ned Tijdschr Geneeskd 116(21):903–904 Ganesh S, Gonzalez-Edick M, Gibbons D, Ge Y, Vanroey M, Robinson M, Jooss K (2008) Combination therapy with radiation or cisplatin enhances the potency of Ad5/35 chimeric oncolytic adenovirus in a preclinical model of head and neck cancer, Cancer Gene Ther Ghobrial IM, Witzig TE, Adjei AA (2005) Targeting apoptosis pathways in cancer therapy. CA Cancer J Clin 55(3):178–194 Hawkins BL, Heniford BW, Ackermann DM, Leonberger M, Martinez SA, Hendler FJ (1994) 4NQO carcinogenesis: a mouse model of oral cavity squamous cell carcinoma. Head Neck 16(5):424–432 Kanojia D, Vaidya MM (2006) 4-Nitroquinoline-1-oxide induced experimental oral carcinogenesis. Oral Oncol 42(7):655–667 Loefﬂer-Ragg J, Schwentner I, Sprinzl GM, Zwierzina H (2008) EGFR inhibition as a therapy for head and neck squamous cell carcinoma. Expert Opin Investig Drugs 17(10):1517–1531 MacDonald DG (1981) Comparison of epithelial dysplasia in hamster cheek pouch carcinogenesis and human oral mucosa. J Oral Pathol 10(3):186–191 Monnerat C, Faivre S, Temam S, Bourhis J, Raymond E (2002) End points for new agents in induction chemotherapy for locally advanced head and neck cancers. Ann Oncol 13(7):995–1006 Nauta JM, Roodenburg JL, Nikkels PG, Witjes MJ, Vermey A (1995) Comparison of epithelial dysplasia–the 4NQO rat palate model and human oral mucosa. Int J Oral Maxillofac Surg 24(1 Pt 1): 53–58 Nauta JM, Roodenburg JL, Nikkels PG, Witjes MJ, Vermey A (1996) Epithelial dysplasia and squamous cell carcinoma of the Wistar rat palatal mucosa: 4NQO model. Head Neck 18(5):441–449 181 Niwa S, Ueno S, Shirasu R (2001) Alteration of pRb expression in the development of rat tongue carcinoma induced by 4-nitroquino- line 1-oxide. Oral Oncol 37(7):579–585 Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55(2):74–108 Perl AK, Wilgenbus P, Dahl U, Semb H, Christofori G (1998) A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature 392(6672):190–193 Schoop RA, Kooistra K, Baatenburg de Jong RJ, Noteborn MH (2004) Bcl-xL inhibits p53- but not apoptin-induced apoptosis in head and neck squamous cell carcinoma cell line. Int J Cancer 109(1):38–42 Schoop RA, Baatenburg de Jong RJ, Noteborn MH (2008) Apoptin induces apoptosis in an oral cancer mouse model. Cancer Biol Ther 7(9):1368–1373 St George JA (2003) Gene therapy progress and prospects: adenoviral vectors. Gene Ther 10(14):1135–1141 Suzuki R, Kohno H, Suzui M, Yoshimi N, Tsuda H, Wakabayashi K, Tanaka T (2006) An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its potential use for preclinical chemoprevention studies. Carcinogenesis 27(3):619–630 Takes RP (2004) Staging of the neck in patients with head and neck squamous cell cancer: imaging techniques and biomarkers. Oral Oncol 40(7):656–667 Tang XH, Knudsen B, Bemis D, Tickoo S, Gudas LJ (2004) Oral cavity and esophageal carcinogenesis modeled in carcinogen- treated mice. Clin Cancer Res 10(1 Pt 1):301–313 van der Eb MM, Pietersen AM, Speetjens FM, Kuppen PJ, van de Velde CJ, Noteborn MH, Hoeben RC (2002) Gene therapy with apoptin induces regression of xenografted human hepatomas. Cancer Gene Ther 9(1):53–61 Videtic GM, Stitt LW, Dar AR, Kocha WI, Tomiak AT, Truong PT, Vincent MD, Yu EW (2003) Continued cigarette smoking by patients receiving concurrent chemoradiotherapy for limited- stage small-cell lung cancer is associated with decreased survival. J Clin Oncol 21(8):1544–1549 Wallenius K, Lekholm U (1973) Oral cancer in rats induced by the water-soluble carcinogen 4-nitrochinoline N-oxide. Odontol Revy 24(1):39–48 Williams HK, Sanders DS, Jankowski JA, Landini G, Brown AM (1998) Expression of cadherins and catenins in oral epithelial dysplasia and squamous cell carcinoma. J Oral Pathol Med 27(7):308–317 Yoshida K, Tanaka T, Hirose Y, Yamaguchi F, Kohno H, Toida M, Hara A, Sugie S, Shibata T, Mori H (2005) Dietary garcinol inhibits 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in rats. Cancer Lett 221(1):29–39 123