Metformin in PCOS Table 1: Comparison of the changes in anthropometric indexes before and after three months treatment (n=45). Before After P value 3-months Weight (kg) 70.9±12.2 70.2±11.9 0.08 BMI (kg/m2) 27.7±4.1 27.4±4.2 0.1 Waist (cm) 96.9±11 95.8±11.4 0.2 Hip (cm) 105±7.3 104±7.3 0.03 WHR 0.92±0.06 0.91±0.07 0.7 Systolic BP (mmHg) 112.3±8.5 113.3±8.1 0.4 Diastolic BP (mmHg) 72.1±8.2 74.4±7.5 0.09 Table 2: comparison of the changes in metabolic parameters before and three months after treatment (n=45)a. Before After 3-months P value Insulin (µU/mL) 11.8±9.6 11.6±8.3 0.9 FPG (mg/dL) 77.3±8.4 79.6±15.1 0.3 TG (mg/dL) 156.3±76.5 157.5±78.3 0.4 Total cholesterol (mg/dL) 191.8±38.5 193.8±40 0.5 LDL 90.3±31.4 90.3±28.3 0.3 HDL 69.8±19.5 71.6±15 0.5 Ferritin (µg/L) 68.5±51.3 35.1±33.9 0.00 hs CRP (mg/L) 3.2±3.7 2.3±2.2 0.05 aFPG, TG and hsCRP denotes fasting plasma glucose, triglyceride and highly sensitive CRP respectively. Pearson's correlation test showed an association be- tween CRP and insulin resistance indexes before inter- vention (p=0.02, r=0.34) (Table 3). There was not asso- ciation between serum ferritin with CRP and insulin resistance either before or after three months of treat- ment (p>0.05).Associations between CRP, HOMA-IR with BMI and WHR before and after the treatment has been presented in Table 4. There was not association between ferritin and these anthropometric indexes either before or three months after treatment (p>0.05). Table 3: Mean±SD of CRP, ferritin and insulin resistance indexes in three groups of obese, overweight and lean before and after treatment. Obese (n=14) Overweight (n=19) Lean (n=12) Before After Before After Before After 3 months 3 months 3 months hs CRP 5.07±5.7 2.9±1.9 2.8±2.4 2.5±2.8 1.4±0.73 1.3±0.38 Ferritin 77.6±43 59.3±48.7 52.3±24.8 23.7±13.5 83.5±80.9 24.8±20.7 HOMA-IR 2.9±1.3 3.5±2.4 1.8±0.9 2.5±1.2 1.3±0.87 0.8±0.25 Table 4: Association of CRP, HOMA-IR with WHR and BMI before and after treatment. CRP HOMA-IR Before After Before After 3 months 3 months BMI r p WHR r p 0.33 0.02 0.23 0.12 0.39 0.008 0.2 0.09 0.43 0.003 0.14 0.35 0.54 0.00 0.41 0.005 WWW.ircmj.com Vol 13 July 2011 489