IL18R1 rs2287033 103011237 intronic Childhood asthma 0.0063 IL18R1 rs3732127 103013750 3' UTR Humoral immunity to Rubella 0.009 Candidate gene study Genetics of Interleukin 1 Receptor-Like 1 in Immune Current Genomics, 2010, Vol. 11, No. 8 601 Gene SNP Chr. Loc. SNP Location Disease/Phenotype pValue Study Population N Refs. IL18R1 rs1420094 103015687 3' UTR Childhood asthma 0.0063 IL18R1 rs1420094 103015687 3' UTR Atopic asthma 0.0063 736 families IL18R1 / IL18RAP rs1035127 103019919 intergenic Crohn's disease 1.2 x 10-4 GWAS IL18RAP rs1420106 103035044 5' near-gene BHR / Total IgE 0.023 / 0.012 IL18RAP rs1420100 103037002 intronic Lumbar disc signal inten- sity 0.005 Candidate gene study IL18RAP rs2272127 103039873 intronic Schizophrenia+Herpes seropositivity 0.03 Candidate gene study Caucasian 478 cases / (Amercican) 501 controls IL18RAP rs917997 103070568 intergenic Coeliac disease 8.49 x 10-10 Candidate gene study_follow-up to GWAS Candidate gene study_follow-up to GWAS Candidate gene study Candidate gene study Mexican Somali Mexican European (Danish, British, Nor- wegian) Caucasian (American, Canadian, Belgian, French, Brit- ish) Dutch Finnish (Table 1). Contd….. Wu et al. - J Al- lergy Clin 492 cases + Immunol both parents 2010 Dhiman et al. - Tissue 89 individu- Antigens als 2008 Wu et al. - J Al- lergy Clin 492 cases + Immunol both parents 2010 Zhu et al. - Eur J Hum Genet 2008 2325 cases / Barrett et 1809 controls al. - Nat + 1339 Genet families 2008 Reijmer- ink et al. - J Al- lergy Clin Immunol 2008 184 / 234 families Videman et al. - Arthritis 588 individu- Rheum als 2009 Shirts et al. - Am J Med Genet B Neuro- psychiatr Genet 2008 Hunt et al. - Nat Genet 2008 Candidate gene study_follow-up to GWAS Northern European 767 cases / 1422 controls