Cuppone et al. Journal of Experimental & Clinical Cancer Research 2011, 30:54 http://www.jeccr.com/content/30/1/54 Page 9 of 9 Advanced Breast Cancer (ABC). Cancer Res 2009, 69:46, (24_MeetingAbstracts). 38. Baselga J, Grupo Espanol de Estudio Tratamiento y Otras Estrategias Experimentales en Tumores S, Roche H, Costa F, Getulio Martins Segalla J, Pinczowski H, Ma Ciruelos E, Cabral Filho S, Gomez P, Van Eyll B: SOLTI- 0701: A Multinational Double-Blind, Randomized Phase 2b Study Evaluating the Efficacy and Safety of Sorafenib Compared to Placebo When Administered in Combination with Capecitabine in Patients with Locally Advanced or Metastatic Breast Cancer (BC). Cancer Res 2009, 69:45, (24_MeetingAbstracts). 39. Gradishar W, Kaklamani V, Prasad Sahoo T, Lokanatha D, Raina V, Bondarde S, Jain M: A Double-Blind, Randomized, Placebo-Controlled, Phase 2b Study Evaluating the Efficacy and Safety of Sorafenib (SOR) in Combination with Paclitaxel (PAC) as a First-Line Therapy in Patients (pts) with Locally Recurrent or Metastatic Breast Cancer (BC). Cancer Res 2009, 69:44, (24_MeetingAbstracts). 40. Mackey J, Hurvitz S, Crown J, Forbes J, Roche H, Pinter T, Eiermann W, Kennedy M, Priou F, Provencher L, et al: CIRG/TORI 010: 10-Month Analysis of a Randomized Phase II Trial of Motesanib Plus Weekly Paclitaxel as First Line Therapy in HER2-Negative Metastatic Breast Cancer (MBC). Cancer Res 2009, 69:47, (24_MeetingAbstracts). 41. Choueiri TK, Mayer EL, Je Y, Rosenberg JE, Nguyen PL, Azzi GR, Bellmunt J, Burstein HJ, Schutz FA: Congestive heart failure risk in patients with breast cancer treated with bevacizumab. J Clin Oncol 29(6):632-638. 42. Ranpura V, Hapani S, Wu S: Treatment-related mortality with bevacizumab in cancer patients: a meta-analysis. Jama 305(5):487-494. 43. Verma N, Swain SM: Bevacizumab and heart failure risk in patients with breast cancer: a thorn in the side? J Clin Oncol 29(6):603-606. 44. Hayes DF: Bevacizumab treatment for solid tumors: boon or bust? Jama 305(5):506-508. doi:10.1186/1756-9966-30-54 Cite this article as: Cuppone et al.: Magnitude of risks and benefits of the addition of bevacizumab to chemotherapy for advanced breast cancer patients: Meta-regression analysis of randomized trials. Journal of Experimental & Clinical Cancer Research 2011 30:54. Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color ﬁgure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit