200 Spontaneous Iron Accumulation in a Young Rat Data of the animal Mean ± SD from concurrent data (including this animal) n=6 APTT: activated partial thromboplastin time. MCV: mean corpuscular volume. MCH: mean corpuscular hemoglobin. MCHC: mean corpuscular hemoglobin concentration. n: number of animals examined. Data of the animal Mean ± SD from concurrent data (including this animal) n=6 Table 1. Hematology Prothrombin time APTT Fibrinogen Red blood cells Hemoglobin Hematocrit MCV MCH MCHC Reticulocytes White blood cells Neutrophils Monocytes Eosinophils Basophils Lymphocytes Platelet count (sec) (sec) (mg/dL) (×106/μL) (g/dL) (%) (fL) (pg) (g/dL) (×104/μL) (×103/μL) (×103/μL) (×103/μL) (×103/μL) (×103/μL) (×103/μL) (×103/μL) Table 2. Blood biochemistry Total protein (g/dL) Albumin (g/dL) Albumin-globulin ratio Glucose (mg/dL) Total cholesterol (mg/dL) Phospholipids (mg/dL) Triglycerides (mg/dL) Urea nitrogen (mg/dL) Creatinine (mg/dL) Total bilirubin (mg/dL) Aspartate aminotransferase (U/L) Alanine aminotransferase (U/L) γ-GTP (U/L) Alkaline phosphatase (U/L) Creatine kinase (U/L) Lactate dehydrogenase (U/L) Sodium (mEq/L) Potassium (mEq/L) Chloride (mEq/L) Calcium (mg/dL) Inorganic phosphorus (mg/dL) 14.5 18.4 277 6.67 14.6 38.6 57.8 21.9 37.9 20.88 1.75 0.23 0.03 0.01 0.01 1.47 872 6.1 2.6 0.74 101 97 150 7 15 0.3 0.04 65 17 2 478 141 127 144 3.5 109 10.3 6.8 15.5 ± 0.5 19.5 ± 1.14 256 ± 22.2 6.91 ± 0.268 14.5 ± 0.56 37.8 ± 1.14 54.8 ± 1.82 21 ± 0.85 38.3 ± 0.77 16.67 ± 4.581 1.85 ± 0.507 0.25 ± 0.136 0.02 ± 0.016 0.02 ± 0.012 0 ± 0.004 1.56 ± 0.383 912 ± 165.1 5.9 ± 0.21 2.5 ± 0.17 0.74 ± 0.05 112 ± 6.3 59 ± 20.4 104 ± 25.6 8 ± 2.9 18 ± 3.2 0.3 ± 0.04 0.05 ± 0.008 63 ± 5 17 ± 2.3 3 ± 0.5 414 ± 120.1 122 ± 18.5 102 ± 16.9 144 ± 1.5 4 ± 0.29 108 ± 1.5 10.2 ± 0.31 7 ± 0.63 γ-GTP: gamma-glutamyl transpeptidase. n: number of animals examined. transferrin and iron saturation levels were not measured. Although no abnormality was noted at necropsy, the liver preserved in 10% neutral buffered formalin solution did show a change in color. The caudal process of the caudal lobe and parts of the area of the left lateral lobe and right medial lobe were reddish brown (Fig. 1). There was a tendency for areas showing abnormal color to be close to the porta hepatis. Microscopically, no abnormalities were recognized in any organs except for the liver in this animal. The spleen also demonstrated no variation from normal. Very fine yellowish-brown pigments were found in the hepatocytes