Chronic myeloid leukemia treatment guidelines: Brazilian Association of Hematology, Hemotherapy and Cell Therapy. Brazilian Medical Association Guidelines Project – 2012 90. Picard S, Titier K, Etienne G, Teilhet E, Ducint D, Bernard MA, et al. Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia. Blood. 2007;109(8):3496-9. Comment in: Blood. 2007;110(5):1699-701; author reply 1701. 91. Reinhold U, Hennig E, Leiblein S, Niederwieser D, Deininger MW. FISH for BCR-ABL on interphases of peripheral blood neutrophils but not of unselected white cells correlates with bone marrow cytogenetics in CML patients treated with imatinib. Leukemia. 2003;17(10):1925-9. 92. Mascarenhas CC, Cunha AF, Miranda EC, Zulli R, Silveira RA, Costa FF, et al. New mutations detected by denaturing high performance liquid chromatography during screening of exon 6 bcr-abl mutations in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors. Leuk Lymphoma. 2009;50(7):1148-54. 93. Olavarria E, Ottmann OG, Deininger M, Clark RE, Bandini G, Byrne J, Lipton J, Vitek A, Michallet M, Siegert W, Ullmann A, Wassmann B, Niederwieser D, Fischer T; Chronic Leukaemia Working Party of the European Group of Bone and Marrow Transplantation (EBMT). Response to imatinib in patients who relapse after allogeneic stem cell transplantation for chronic myeloid leukemia. Leukemia. 2003;17(9):1707-12. Comment in: Leukemia. 2003;17(9):1722. 94. Crawley C, Szydlo R, Lalancette M, Bacigalupo A, Lange A, Brune M, Juliusson G, Nagler A, Gratwohl A, Passweg J, Komarnicki M, Vitek A, Mayer J, Zander A, Sierra J, Rambaldi A, Ringden O, Niederwieser D, Apperley JF; Chronic Leukemia Working Party of the EBMT. Outcomes of reduced-intensity transplantation for chronic myeloid leukemia: an analysis of prognostic factors from the ChronicLeukemia Working Party of the EBMT. Blood. 2005;106(9):2969-76. 95. Lee SJ, Kukreja M, Wang T, Giralt SA, Szer J, Arora M, et al. Impact of prior imatinib mesylate on the outcome of hematopoietic cell transplantation for chronic myeloidleukemia. Blood. 2008;112(8):3500-7. 96. Burke MJ, Trotz B, Luo X, Weisdorf DJ, Baker KS, Wagner JE, et al. Imatinib use either pre- or post-allogeneic hematopoietic cell transplantation (allo-HCT) does not increase cardiac toxicity in chronic myelogenous leukemiapatients. Bone Marrow Transplant. 2009;44(3):169-74. 97. Luo Y, Zhao Y, Tan Y, Shi J, Han X, Zheng Y, et al. Imatinib combined with myeloablative allogeneic hematopoietic stem cell transplantation for advanced phases of chronic myeloid leukemia. Leuk Res. 2011;35(10):1307-11. 98. Jiang Q, Xu L, Liu D, Liu K, Chen S, Jiang B, et al. Imatinib mesylate versus allogeneic hematopoietic stem cell transplantation for patients with chronic myelogenous leukemia in the accelerated phase. Blood. 2011;117(11):3032-3040. 99. Boehm A, Walcherberger B, Sperr WR, Wöhrer S, Dieckmann K, Rosenmayr A, et al.Improved outcome in patients with chronic myelogenous leukemia after allogeneichematopoietic stem cell transplantation over the past 25 years: a single-centerexperience. Biol Blood Marrow Transplant. 2011;17(1):133-40. 100. Breccia M, Palandri F, Iori AP, Colaci E, Latagliata R, Castagnetti F, et al. Second-generation tyrosine kinase inhibitors before allogeneic stem cell transplantation in patients with chronic myeloid leukemia resistant to imatinib. Leuk Res. 2010;34(2):143-7. 101. Millot F, Baruchel A, Guilhot J, Petit A, Leblanc T, Bertrand Y, et al. Imatinib is effective in children with previously untreated chronic myelogenous leukemia in early chronic phase: results of the French national phase IV trial. J Clin Oncol. 2011;29(20):2827-32. 102. Suttorp M, Claviez A, Bader P, Peters C, Gadner H, Ebell W, Dilloo D, Kremens B, Kabisch H, Führer M, Zintl F, Göbel U, Klingebiel T. Klin Padiatr. Allogeneic stem cell transplantation for pediatric and adolescent patients with CML: results from the prospective trial CML-paed I. Klin Padiatr. 2009;221(6):351-7. Appendix 1 PICO 1 Search strategies and words used in to answer the clinical questions: PICO 2 What are the diagnostic criteria for chronic myeloid leukemia? (Leukemia, Myelogenous, Chronic, BCR-ABL Positive OR Leukemia, Myeloid, Philadelphia-Positive OR Leukemia, Granulocytic, Chronic OR Myeloid Leukemia, Chronic OR Chronic Myeloid Leukemia OR Leukemia, Myelocytic, Chronic OR Chronic Myelocytic Leukemia OR Leukemia, Myelogenous, Chronic OR Myelogenous Leukemia, Ph1-Positive OR Leukemia, Myeloid, Ph1 Positive OR Myelogenous Leukemia, Chronic OR Myeloid Leukemia, Philadelphia-Positive OR Granulocytic Leukemia, Chronic OR Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative) AND (classification OR criteria OR World Health Organization* OR standards*) AND (sensitiv*[Title/ Abstract] OR sensitivity and specificity[MeSH Terms] OR diagnos*[Title/Abstract] OR diagnosis[MeSH:noexp] OR diagnostic * [MeSH:noexp] OR diagnosis,differential[MeSH :noexp] OR diagnosis[Subheading:noexp]) Is there any difference in the prognosis of CML patients with p210, e13a2(b2a2) and e14a2(b3a2) or (e1a2)p190 rearrangements? (Leukemia, Myelogenous, Chronic, BCR-ABL Positive OR Leukemia, Myeloid, Philadelphia-Positive OR Leukemia, Granulocytic, Chronic OR Myeloid Leukemia, Chronic OR Chronic Myeloid Leukemia OR Leukemia, Myelocytic, Chronic OR Chronic Myelocytic Leukemia OR Leukemia, Myelogenous, Chronic OR Myelogenous Leukemia, Ph1-Positive OR Leukemia, Myeloid, Ph1 Positive OR Myelogenous Leukemia, Chronic OR Myeloid Leukemia, Philadelphia-Positive OR Granulocytic Leukemia, Chronic) AND ((Fusion Proteins, bcr-abl AND genetics*) OR p210 OR e13a2 OR b2a2 OR e14a2 OR b3a2 OR p190 OR e1a2 OR Isoform*) AND (prognos*[Title/ Abstract] OR (first[Title/Abstract] AND episode[Title/Abstract]) OR cohort[Title/Abstract]) PICO 3 At diagnosis, do the Philadelphia chromosome and the 9q deletion have prognostic significance? Rev Bras Hematol Hemoter. 2012;34(5):367-82 379