PIP3 and PIP2 activation of vascular TRPC1 5375 All authors were involved in revising the manuscript and approved the ﬁnal version. Acknowledgements This work was supported by The Wellcome Trust. J Physiol 587.22 Author contributions S.N.S. carried out the experimental work and ﬁgure preparation. A.P.A. and W.A.L. were involved in the conception and design of the study, interpretation of data, and drafting of the manuscript. C 2009 The Authors. Journal compilation C 2009 The Physiological Society