Genetics of Interleukin 1 Receptor-Like 1 in Immune Current Genomics, 2010, Vol. 11, No. 8 597 Gene SNP Chr. Loc. SNP Location Disease/Phenotype pValue Study Population N Refs. IL1RL1 rs1420101 102957716 intronic Asthma 5.5 x 10-12 IL1RL1 rs2160203 102960824 3' UTR Chronic rhinosinusitis 0.03 IL1RL1 rs1946131 102961929 intronic Asthma / Atopy 0.015 / 0.050 IL1RL1 rs17027006 102965332 intronic Total IgE 0.02 IL1RL1 rs1921622 102966067 intronic Specific IgE egg 1-2 years 0.04 Candidate gene 9 European + 7996 cases / study_follow-up 1 East Asian 44890 con- to GWAS populations trols Candidate gene study_follow-up to GWAS Candidate gene study Candidate gene study Candidate gene study-gene-gene interaction analy- sis Candidate gene study-gene-gene interaction analy- sis French- Canadian French- Canadian founder population Dutch Dutch Dutch Cod.non.syn (78Ala>Glu) IL1RL1 rs1041973 102955468 Childhood asthma 0.00035 Mexican IL1RL1 rs1420101 102957716 intronic Eosinophil count 5.3 x 10-14 GWAS Icelandic IL1RL1 rs1921622 102966067 intronic BHR / asthma / Total IgE 0.014 / 0.038 Candidate gene / 0.027 study IL1RL1 rs10208293 102966310 intronic Chronic rhinosinusitis 0.03 IL1RL1 rs10208293 102966310 intronic Specific IgE indoor aller- gens 6-8 years 0.03 Candidate gene study Candidate gene study-gene-gene interaction analy- sis French- Canadian 206 cases / 196 controls Dutch Reijmer- ink et al. 3062 children - Allergy (birth cohort) 2010 (Table 1). Contd….. Wu et al. - J Al- lergy Clin 492 cases + Immunol both parents 2010 9392 indi- viduals Gudbjarts son et al. - Nat Genet 2009 Gudbjarts son et al. - Nat Genet 2009 Castano et al. - Am J Rhinol Allergy 2009 206 cases / 196 controls Bossé et al. - 53 / 42 fami- Respir lies Res 2009 Reijmer- ink et al. 3062 children - Allergy (birth cohort) 2010 Reijmer- ink et al. 3062 children - Allergy (birth cohort) 2010 Reijmer- ink et al. - J Al- lergy Clin 212 / 193 / Immunol 276 families 2008 Castano et al. - Am J Rhinol Allergy 2009