596 Current Genomics, 2010, Vol. 11, No. 8 Akhabir and Sandford Table 1. Gene SNP Chr. Loc. SNP Location Disease/Phenotype pValue Study Population N Refs. IL1RL1 rs949963 102769786 5' near-gene Childhood asthma 0.033 Mexican Cod.non.syn (78Ala>Glu) Cod.non.syn (78Ala>Glu) IL1RL1 rs1041973 102955468 Course of hepatitis C 0.004 Japanese 238 cases IL1R1 rs3917289 102781911 intronic Childhood asthma 0.022 IL1RL1 rs11685424 102926981 5' near-gene Childhood asthma 0.04 IL1RL1 rs11685480 102927086 5' near-gene Specific IgE egg 1-2 years 0.02 IL1RL1 rs6543116 102927726 promoter Atopic dermatitis 0.000007 IL1RL1 rs1420089 102938389 intronic Asthma 0.033 Candidate gene study_follow-up to GWAS Candidate gene study_follow-up to GWAS Candidate gene study_follow-up to GWAS Candidate gene study-gene-gene interaction analy- sis Candidate SNP study Candidate gene study Mexican Mexican Dutch Japanese French- Canadian founder population Candidate gene study_follow-up to GWAS Candidate gene study Canadian birth cohort Candidate gene study Wu et al. - J Al- lergy Clin 492 cases + Immunol both parents 2010 Wu et al. - J Allergy Clin 492 cases + Immunol both parents 2010 Wu et al. - J Al- lergy Clin 492 cases + Immunol both parents 2010 Reijmer- ink et al. 3062 children - Allergy (birth cohort) 2010 Shimizu et al. - Hum Mol Genet 2005 452 cases / 636 controls Bossé et al. - Respir 72 families Res 2009 Wu et al. - J Al- lergy Clin 492 cases + Immunol both parents 2010 Bossé et al. - Respir 98 families Res 2009 Castano et al. - Am J Rhinol Allergy 2009 Saito et al. - Biochem Biophys Res Commun 2004 IL1RL1 rs13431828 102954653 5' UTR Chronic rhinosinusitis 0.008 Candidate gene study French- Canadian 206 cases / 196 controls IL1RL1 rs13431828 102954653 5' UTR Childhood asthma 0.0002 Mexican IL1RL1 rs1041973 102955468 Atopy 0.046