Tension cost and contractility changes Moreira CM et al. 13. Rupp H, Elimban V, Dhalla NS. Diabetic-like action of intermittent fasting on sarcoplasmic reticulum Ca2+ pump ATPase and myosin isoenzymes can be prevented by sucrose. Biochem Biophys Res Commun. 1989;164(1):319-25, http://dx.doi.org/10.1016/0006- 291X(89)91720-8. 14. Bartunek J, Weinberg EO, Tajima M, Rohrbach S, Katz SE, Douglas PS, et al. Chronic NG-Nitro-L-Arginine methyl Ester-induced Hypertension. Novel Molecular Adaptation to Systolic Load in Absence of Hypertrophy. Circulation. 2000;101(4):423-9. 15. Brenner B. Effect of Ca2+ on cross-bridge turnover kinetics in skinned single rabbit psoas fibers: implications for regulation of muscle contraction. Proc Natl Acad Sci U S A. 1988;85(9):3265-9, http:// dx.doi.org/10.1073/pnas.85.9.3265. 16. Saeki Y. Crossbridge dynamics under various inotropic states in cardiac muscle: evaluation by perturbation analyses. Jpn J Physiol. 1995;45(5):687-705, http://dx.doi.org/10.2170/jjphysiol.45.687. 17. Rundell VLM, Geenen DL, Buttrick PM, Tombe PP. Depressed cardiac tension cost in experimental diabetes is due to altered myosin heavy chain isoform expression. Am J Physiol Heart Circ Physiol. 2004;287(1):H408-H413, http://dx.doi.org/10.1152/ajpheart.00049.2004. 18. Vassallo DV, Vasquez EC, Cabral AM. Contractile performance of papillary muscles of renovascular hypertensive and isoproterenol- pretreated rats. Pharmacol Res Comm. 1988;20(1):61-72, http://dx.doi. org/10.1016/S0031-6989(88)80607-6. 19. Mill JG, Leite CM, Vassallo DV. Right ventricular contractility depression in chronically infarcted rats. Braz J Med Biol Res. 1988;21(3):621-4. 20. Leite CM, Mill JG, Vassallo DV. Characteristics of tetanic contractions in the caffeine treated rat myocardium. Can J Physiol Pharmacol. 1995;73(5):638-43, http://dx.doi.org/10.1139/y95-081. 21. Chan K, Delfert D, Junger KD. A direct colorimetric assay for Ca2+- ATPase activity. Anal Biochem 1986;157(2):375-80. 22. Bradford MM. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:218-54, http://dx.doi.org/10.1016/0003- 2697(76)90527-3. 23. Mill JG, Novaes MAS, Galon M, Nogueira JB, Vassallo DV. Comparison of the contractile performance of the hypertrophied myocardium from spontaneous hypertensive rats and normotensive infarcted rats. Can J Physiol Pharmacol. 1998;76(4):387-394, http://dx.doi.org/10.1139/ y98-013. 24. Novaes MAS, Stefanon I, Mill JG, Vassallo DV. Contractility changes of the right and left ventricular muscle after chronic myocardial infaction. Braz J Med Biol Res. 1996;29(12):1683–90. 25. Pereira RB, Sarto´ rio CL, Vassallo DV, Stefanon I. Differences in tail vascular bed reactivity in rats with and without heart failure following myocardial infarction. J Pharmacol Exp Ther. 2005; 312(3):1321-5. 26. Min J-Y, Ding B, Wang J-F, Sullivan MF, Morgan JP. Metoprolol attenuates postischemic depressed myocardial function in papillary muscles isolated from normal and postinfarction rat hearts. CLINICS 2012;67(5):489-496 Eur J Pharmacol. 2001;422(1-3):115-25, http://dx.doi.org/10.1016/ S0014-2999(01)01050-0. 27. Geenen DL, White TP, Lampman RM. Papillary mechanics and cardiac morphology of infarcted rat hearts after training. J Appl Physiol. 1987;63(1):92-6. 28. Lefroy DC, Crake T, Del Monte F, Vescovo G, Dalla Libera L, Harding S, et al. Angiotensin II and contraction of isolated myocytes from human, guinea pig, and infarcted rat hearts. Am J Physiol. 1996;270(6 Pt 2)H2060- 9. 29. Manso AM, Encabo A, Ferrer M, Balfago´ n G, Salaices M, Mar´ın J. Changes of cardiac calcium homeostasis in spontaneously hypertensive rats. J Auton Pharmacol. 1999;19(2):123-30, http://dx.doi.org/10.1046/ j.1365-2680.1999.00127.x. 30. Shorofsky SR, Aggarwal R, Corretti M, Baffa JM, Strum JM, Al-Seikhan BA, et al. Cellular mechanisms of altered contractility in the hyper- trophied heart: big hearts, big sparks. Circ Res. 1999;84(4):424-34. 31. Bokn´ık P, Heinroth-Hoffmann I, Kirchhefer U, Knapp J, Linck B, L u¨ss H, et al. Enhanced protein phosphorylation in hypertensive hypertrophy. Cardiovasc Res. 2001;51(4):717-28, http://dx.doi.org/10.1016/S0008- 6363(01)00346-7. 32. Morano I, Gagelmann M, Arner A, Ganten U, R u¨egg JC. Myosin isoenzymes of vascular smooth and cardiac muscle in the spontaneously hypertensive and normotensive male and female rat: a comparative study. Circ Res. 1986;59(4):456-62. 33. Brooks WW, Bing OH, Boluyt MO, Malhotra A, Morgan JP, Satoh N, et al. Altered inotropic responsiveness and gene expression of hypertrophied myocardium with captopril. Hypertension. 2000;35(6):1203-9. 34. McCullought AL, McNeill JH. Chronic diabetes decreases the ouabain inotropic response in rat left atria and papillary muscles. Gen Pharmacol. 1983;14(4):401-5. 35. Morris GS, Prevost MC, Nelson AG. Moderate diabetes alters myosin isoenzyme distribution in cardiac but not skeletal muscle of male rats. Life Sci. 1996;58(10):833-8, http://dx.doi.org/10.1016/0024- 3205(96)00016-1. 36. Pedroni P, Perez GN, Mattiazzi A. Calcium sensitivity of isometric tension in intact papillary muscles and chemically skinned trabeculae in different models of hypertensive hypertrophy. Cardiovasc Res. 1990;24(7):584-90, http://dx.doi.org/10.1093/cvr/24.7.584. 37. Besse S, Assayag P, Delcayre C, Carre F, Cheav SL, Lecarpentier Y, et al. Normal and hypertrophied senescent rat heart: mechanical and molecular characteristics. Am J Physiol. 1993;265(1 Pt 2):H183-90. 38. Takaori K, Kim S, Ohta K, Hamaguchi A, Yagi K, Iwao H. Inhibition of nitric oxide synthase causes cardiac phenotypic modulation in rat. Eur J Pharmacol. 1997;322(1):59-62, http://dx.doi.org/10.1016/S0014- 2999(97)00058-7. 39. Oliveira CF, Cintra KA, Teixeira SA, De Luca IMS, Antunes E, De Nucci G. Development of cardiomyocyte hypotrophy in rats under prolonged treatment with a low dose of a nitric oxide synthesis inhibitor. Eur J Pharmacol. 2000;391(1-2):121-6, http://dx.doi.org/10.1016/S0014- 2999(99)00929-2. 496