Polman et al: 2010 Revisions to MS Diagnosis multiple sclerosis and other neurological diseases. J Neuroimmu- nol 2009;217:95–101. 64. Quintana FJ, Farez MF, Viglietta V, et al. Antigen microarrays identify unique serum autoantibody signatures in clinical and path- ologic subtypes of multiple sclerosis. Proc Natl Acad Sci U S A 2008;105:18889–18894. 65. Keller A, Leidinger P, Lange J, et al. Multiple sclerosis: microRNA expression profiles accurately differentiate patients with relapsing- remitting disease from healthy controls. PLoS One 2009;4:e7440. 66. Frohman EM, Balcer LJ, Calabresi PA. Multiple sclerosis: can reti- nal imaging accurately detect optic neuritis? Nat Rev Neurol 2010;6:125–126. 67. Bø L, Vedeler CA, Nyland H, et al. Intracortical multiple sclerosis lesions are not associated with increased lymphocyte infiltration. Mult Scler 2003;9:323–331. 68. Bø L, Vedeler CA, Nyland HI, et al. Subpial demyelination in the cerebral cortex of multiple sclerosis patients. J Neuropathol Exp Neurol 2003;62:723–732. Geurts JJ, Pouwels PJ, Uitdehaag BM, et al. Intracortical lesions in multiple sclerosis: improved detection with 3D double inversion- recovery MR imaging. Radiology 2005;236:254–260. 70. Calabrese M, De Stefano N, Atzori M, et al. Detection of cortical inflammatory lesions by double inversion recovery magnetic reso- nance imaging in patients with multiple sclerosis. Arch Neurol 2007;64:1416–1422. Nelson F, Poonawalla A, Hou P, et al. 3D MPRAGE improves clas- sification of cortical lesions in multiple sclerosis. Mult Scler 2008; 14:1214–1219. Nelson F, Poonawalla A, Hou P, et al. Improved identification of intracortical lesions in multiple sclerosis with phase-sensitive inver- sion recovery in combination with fast double inversion recovery MR imaging. Am J Neuroradiol 2007;28:1645–1649. 73. Calabrese M, Rocca MA, Atzori M, et al. Cortical lesions in pri- mary progressive multiple sclerosis: a 2-year longitudinal MR study. Neurology 2009;72:1330–1336. 74. Calabrese M, Rocca MA, Atzori M, et al. A 3-year magnetic reso- nance imaging study of cortical lesions in relapsing-onset MS. Ann Neurol 2010;67:376–383. 75. Filippi M, Rocca MA, Calabrese M, et al. Intracortical lesions: rele- vance for new MRI diagnostic criteria for multiple sclerosis. Neu- rology 2010;75:1988–1994. Wattjes MP, Harzheim M, Lutterbey GG, et al. Does high field MRI allow an earlier diagnosis of multiple sclerosis? J Neurol 2008;255:1159–1163. Wattjes MP, Barkhof F. High field MRI in the diagnosis of multiple sclerosis: high field-high yield? Neuroradiology 2009;51:279–292. 46. 47. 50. 41. Lana-Piexoto MA. Devic’s neuromyelitis optica: a critical review. Arq Neuropsiquiatr 2008;66:120–138. 42. Yeh EA, Chitnis T, Krupp L, et al. Pediatric multiple sclerosis. Nat Rev Neurol 2009;5:621–631. 43. Banwell B, Ghezzi A, Bar-Or A, et al. Multiple sclerosis in children: clinical diagnosis, therapeutic strategies, and future directions. Lancet Neurol 2007;6:887–902. 44. Venkateswaran S, Banwell B. Pediatric multiple sclerosis. Neurolo- gist 2010;16:92–105. 45. Hahn JS, Pohl D, Rensel M, et al. Differential diagnosis and evalu- ation in pediatric multiple sclerosis. Neurology 2007;68(suppl 2): S13–S22. Ghassemi R, Antel SB, Narayanan S, et al. Lesion distribution in children with clinically isolated syndromes. Ann Neurol 2008;63: 401–405. Waubant E, Chabas D, Okuda DT, et al. Difference in disease bur- den and activity in pediatric patients on brain magnetic resonance imaging at time of multiple sclerosis onset vs adults. Arch Neurol 2009;66:967–971. 48. Yeh EA, Weinstock-Guttman B, Ramanathan M, et al. Magnetic res- onance imaging characteristics of children and adults with paediat- ric-onset multiple sclerosis. Brain 2009;132(pt 12):3392–3400. 49. Chabas D, Castillo-Trivino T, Mowry EM, et al. Vanishing MS T2- bright lesions before puberty. Neurology 2008;71:1090–1093. Mikaeloff Y, Adamsbaum C, Husson B, et al. MRI prognostic fac- tors for elapse after acute CNS inflammatory demyelination in childhood. Brain 2004;127:1942–1947. 51. Ketelslegers IA, Neuteboom RF, Boon M, et al. A comparison of MRI criteria for diagnosing pediatric ADEM and MS. Neurology 2010;74:1412–1415. 52. Verhey L, Branson HM, Makhija M, et al. Magnetic resonance imaging features of the spinal cord in pediatric multiple sclerosis: a preliminary study. Neuroradiology 2010;52:1153–1162. 53. Krupp LB, Banwell B, Tenembaum S, et al. Consensus definitions proposed for pediatric multiple sclerosis and related disorders. Neurology 2007;68(suppl 2):S7–S12. 54. Callen DJA, Shroff MM, Branson HM, et al. Role of MRI in the differ- entiation of ADEM from MS in children. Neurology 2009;72:968–973. 55. Matsuoka T, Matsushita T, Kawano Y, et al. Heterogeneity of aquaporin-4 autoimmunity and spinal cord lesions in Japanese. Brain 2007;130:1206–1223. 56. Takahashi T, Fujihara K, Nakashima I, et al. Anti-aquaporin-4 anti- body is involved in the pathogenesis of NMO: a study on anti- body titre. Brain 2007;130;1235–1243. 57. 58. 59. Osoegawa M, Kira J, Fukazawa T, et al. Temporal changes and geo- graphic differences in multiple sclerosis phenotypes in Japanese: nationwide survey results over 30 years. Mult Scler 2009;15:159–173. Nakashima I, Fukazawa T, Ota K, et al. Two subtypes of optic-spi- nal form of multiple sclerosis in Japan: clinical and laboratory fea- tures. J Neurol 2007;254:488–492. Wingerchuk DM, Lennon VA, Pittock SJ, et al. Revised diagnostic criteria for neuromyelitis optica. Neurology 2006;66:1485–1489. 60. Sato D, Fujihara K. NMO without typical opticospinal phenotype. Mult Scler 2010;16:1154–1155. 61. Smith CH, Waubant E, Langer-Gould A. Absence of neuromyelitis optica IgG antibody in an active relapsing-remitting multiple scle- rosis population. J Neuroopthalmol 2009;29:104–106. 62. Awad A, Hemmer B, Hartung HP, et al. Analysis of cerebrospinal fluid in the diagnosis and monitoring of multiple sclerosis. J Neu- roimmunol 2010;219:1–7. 63. Brettschneider J, Jaskowski TD, Tumani H, et al. Serum anti- GAGA4 IgM antibodies differentiate relapsing remitting and sec- ondary progressive multiple sclerosis from primary progressive 69. 71. 72. 76. 77. 79. 78. Stankiewicz JM, Neema M, Alsop DC, et al. Spinal cord lesions and clinical status in multiple sclerosis: a 1.5 T and 3T MRI study. J Neurol Sci 2009;279:99–105. Wattjes MP, Lutterbey GG, Gieseke J, et al. Double inversion re- covery brain imaging at 3T: diagnostic value in the detection of multiple sclerosis. Am J Neuroradiol 2007;28:54–59. 80. Hammond KE, Metcalf M, Carvajal L, et al. Quantitative in vivo magnetic resonance imaging of multiple sclerosis at 7 Tesla with sensitivity to iron. Ann Neurol 2008;64:707–713. 81. Mainero C, Benner T, Radding A, et al. In vivo imaging of cortical pathology in multiple sclerosis using ultra-high field MRI. Neurol- ogy 2009;73:941–948. 82. Kangarlu A, Bourekas EC, Ray-Chaudhury A, Rammohan KW. Cer- ebral cortical lesions in multiple sclerosis detected by MR imaging at 8 Tesla. Am J Neuroradiol 2007;28:262–266. 83. Kollia K, Maderwald S, Putzki N, et al. First clinical study on ultra- high-field MR imaging in patients with multiple sclerosis: compari- son of 1.5T and 7T. Am J Neuroradiol 2009;30:699–702. February 2011 301