Case Reports in Medicine 6. Discussion Migraine is an important comorbid disease in bipolar pa- tients. It not only strengthens the cause of bipolar disorder but also worsens the recurrence rate with regard to depressive episodes. Bipolar II patients have a higher susceptibility of having comorbid migraine. The literature survey with regard to the origins of both diseases indicates a variety of theories and working points. It is important to consider both the multifactor genesis of aﬀective diseases and the inﬂuence of psychic disorders on neurological disorders such as migraine. We do not know yet whether bipolar disorder has causal or merely accidental connections with migraine. Nor do we know what organic or psychic conditions might exactly link the diseases, or why some patients have the comorbidities and others do not. Furthermore, many other psychic and neurological disorders can be comorbid with bipolar disorder. 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