A 100% 75% 50% 25% 0% C 100% 75% 50% 25% 0% E 100% 75% 50% 25% 0% B 100% 75% 50% 25% 0% D 100% 75% 50% 25% 0% F 100% 75% 50% 25% 0% Phase One Test Phase One Test Phase One Test Phase One Test Phase Tw o 1994 – 2002 Phase Tw o 1994 – 2002 Manicaland Kisesa Manicaland Kisesa 45 to 59 year old deaths 45 to 59 year old deaths Phase Tw o 1994 – 2002 Phase Tw o 1994 – 2002 Manicaland Kisesa Manicaland Kisesa 15 to 44 year old deaths, using only criteria available from INDEPTH 15 to 44 year old deaths, using only criteria available from INDEPTH R e s e a r c h r e p o r t Figure 2 Sensitivity and speciﬁcity of the trained algorithm. The dashed line represents the performance of the algorithm on the training dataset. Panels A to D use the full set of nine signs and symptoms. Panels E and F use a smaller set of ﬁve signs/symptoms available from the current INDEPTH tool. Sensitivity Specificity 15 to 44 year old deaths 15 to 44 year old deaths Phase Tw o Manicaland 1994 – 2002 Kisesa Phase Tw o Manicaland 1994 – 2002 Kisesa Table 3 Signs and symptoms for surveillance of AIDS mortality, and the availability in INDEPTHdanother widely used verbal autopsy questionnaire Sign/symptom Weight loss Herpes zoster Jaundice Vaginal tumours Wasting Acute respiratory tract illness Abscesses or sores Oral candidiasis Diarrhoeal disease TB, tuberculosis; VA, verbal autopsy. Deﬁnition based on verbal autopsy question Moderate or severe weight loss with no other symptoms of malnutrition Ever suffered from zoster Acute jaundice (yellowing of the whites of the eyes during the disease that lead to death) with fever and/or itching but without history of alcohol abuse Vaginal tumour for at least 1 month with or without bleeding Moderate or severe weight loss with at least four of the following symptoms: paleness, changing hair colour, oedema of legs, burning sensations of the feet, dry scaly skin Trouble breathing, cough lasting 3e27 days with fever but not recent TB, weight loss or wasting, as above Had abscesses or sores Had two or three of the following: ulcers in the mouth, difﬁculty swallowing, white patches inside the mouth and tongue Loose stools lasting 3e99 days, with or without dehydration Yes Yes No Yes Equivalent in INDEPTH VA questionnaire Not speciﬁcally mentioned (shingles, zoster, herpes) but questions on rash, including where the rash is located (not if it is one-sided) and if the rash has blisters. No mention of pain during or after rash Two out of the ﬁve symptoms (but different phrasing): paleness oedema of ankles. No mention of changing hair colour, burning feet dry scaly skin (might be identiﬁed as rash) Partial cough, with duration fever shortness of breathing noisy breathing. TBddoes not specify when No sores not mentioned, “other swellings or ulcers” No difﬁculty swallowing J Epidemiol Community Health 2010;64:330e334. doi:10.1136/jech.2008.081554 333