Int. J. Environ. Res. Public Health 2010, 7 4.1. Environmental Protection Administration (EPA) 4.1.1. Toxic Chemical Substances Control Act (TCSCA) 3623 The Toxic Chemical Substances Control Act (TCSCA), passed in Nov. 1986 and amended several times, was formulated to prevent toxic chemical substances from polluting the environment and endangering human health. As summarized in Table 6, some pesticides-POPs have been listed under the authorization of the TCSCA. Herein, the toxicity classification is subject to the following definitions: Class-1 toxic chemical substance: chemical substances that are not prone to decompose in the environment and may pollute the environment or endanger human health due to bioaccumulation, bioconcentration or biotransformation. Table 6. Pesticide-POPs designated as toxic substances under the Toxic Chemical Substances Control Act in Taiwan. Control level Threshold Regulation Toxicity Pesticide-POPs Regulatory status (wt%) quantity (kg) classification Aldrin 1 50 1, 3 Manufacture, import, sale, and use prohibited a Chlordane 1 50 1, 3 Manufacture, import, sale, and use prohibited DDT 1 50 1, 3 Manufacture, import, sale, and use prohibited Dieldrin 1 50 1, 3 Manufacture, import, sale, and use prohibited Endrin 1 50 1, 3 Manufacture, import, sale, and use prohibited Heptachlor 1 50 1, 3 Manufacture, import, sale, and use prohibited Hexachlorobenzene 1 50 1 Manufacture, import, sale, and use prohibited α-Hexachlorocyclohexane 1 50 1, 3 Manufacture, import, sale, and use prohibited β-Hexachlorocyclohexane 1 50 1, 3 Manufacture, import, sale, and use prohibited Lindane 1 50 1, 3 Manufacture, import, sale, and use prohibited Toxaphene 1 50 1 Manufacture, import, sale, and use prohibited a It is still used for the following purposes: testing, research and education. Class-3 toxic chemical substances: chemical substances that endanger human health or the lives of biological organisms immediately upon exposure. Table 6 also lists the announcements of their regulatory status, control level and the threshold regulation quantity. It should be noted that most pesticide-POPs listed in Table 6 have been designated as both the Class-1 and Class-3 toxic chemical substances due to their toxicological and persistent