448 Tab. 1. D.-Y. Lu et al.: Radioactivity distributions (Probimane concentrations) in different tissues of mice bearing Lewis lung carcinoma by ig 14C-probimane 120mg/Kg Tissues Brain Skin Muscle Bone Gall bladder Primary tumor Metastatic tumor Heart Lung Testis Liver Spleen Kidney Stomach Bowel Blood Probimane concentrations (ng/g tissues) 2 hrs 24 hrs 48 hrs 17.8 ± 2.0 9.7 ± 3.0 2.2 ± 1.0 163.1 ± 10.9 67.2 ± 5.8 25.3 ± 1.7 122.6 ± 15.4 34.0 ± 3.1 15.0 ± 1.5 90.1 ± 11.3 48.0 ± 7.3 15.1 ± 2.8 648.7 ± 59.9 92.7 ± 10.0 26.9 ± 2.3 70.1 ± 5.6 24.1 ± 2.6 7.7 ± 1.1 142.3 ± 6.9 106.3 ± 7.0 121.5 ± 9.7 124.7 ± 13.6 22.8 ± 1.9 7.2 ± 0.7 149.5 ± 12.2 38.5 ± 2.9 29.2 ± 3.2 444.5 ± 25.0 46.5 ± 3.6 20.0 ± 2.5 370.6 ± 26.7 39.0 ± 4.7 15.3 ± 3.3 365.3 ± 16.4 22.4 ± 2.3 15.9 ± 4.1 446.8 ± 32.5 117.4 ± 9.9 22.7 ± 2.0 1155.3 ± 45.7 107.2 ± 12.3 20.1 ± 2.5 261.8 ± 17.4 60.1 ± 4.7 122.3 ± 14.6 202.4 ± 15.7 27.6 ± 2.0 3.3 ± 0.5 The excretion of 14C-Pro: The excretion of 14C-Pro was almost at the same ratios from urine and feces and in constant rates within the whole experiment Table2. It is a useful excretive data for us to understand the general characteristics and functions of Pro in living-bodies. Tab. 2. The radioactivity excretion from mice bearing Lewis lung carcinoma by ig 14C-probimane 120mg/Kg Time (hrs) 24 48 Excretion (%) Urine Feces Total 18.7 ± 1.7 16.5 ± 1.5 35.2 ± 3.0 33.9 ± 2.5 32.0 ± 2.8 65.9 ± 4.4 Discussion Since tumor metastasis is responsible for more than 60% of cancer deaths worldwide, metastasis therapy, as a result, remains to be one of the biggest challenges among all cancer therapeutics researches. Biz compounds are well-known for their antimetastasis action and several of their putative mechanisms [10–14]. However, their new modes of action and therapeutic profiles remain to be investigated for further understanding and proposition for their potential clinical availability. This work is a typical one. The inhibition of neoplasm metastasis by Raz has been previously explained as a result of reduction in the formation of blood vessels in primary tumor tissues (neovasculature) [10–12]. Thus, it has been proposed that Raz remains ineffective against the pulmonary metastases of 3LL Sci Pharm. 2010; 78: 445–450.