Zhu et al. Journal of Experimental & Clinical Cancer Research 2012, 31:31 http://www.jeccr.com/content/31/1/31 Page 7 of 7 Author details 1National Nanjing New Drug Screening Center, China Pharmaceutical University, Nanjing 210009, Peoples Republic of China. 2Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing 210009, Peoples Republic of China. Authors’ contributions JZ proposed the study and wrote the first draft. LS and SSL modified the draft. RPZ contributed to the design of the study. LQZ and DDF helped analyzed the data. LC, JL and WTS aided with manuscript preparation. LYZ and STY provided the necessary funding. All authors read and approved the final manuscript. Competing interests The authors declare that they have no competing interests. Received: 6 January 2012 Accepted: 31 March 2012 Published: 31 March 2012 References 1. Woodland RT, Schmidt MR, Thompson CB: BLyS and B cell homeostasis. Semin Immunol 2006, 18:318-326. 2. 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Patke A, Mecklenbrauker I, Erdjument-Bromage H, Tempst P, Tarakhovsky A: BAFF controls B cell metabolic fitness through a PKC beta- and Akt- dependent mechanism. J Exp Med 2006, 203:2551-2562. doi:10.1186/1756-9966-31-31 Cite this article as: Zhu et al.: BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells. Journal of Experimental & Clinical Cancer Research 2012 31:31. Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color ﬁgure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit