C a s e r e p o r t will require additional public health and healthcare resources which are expected to contribute cost savings associated with healthier HIV patients and fewer new infections. HIE deﬁned as ‘organized entities that specialize in facilitating electronic HIE among a diverse group of often competing healthcare system stakeholders, such as hospitals and physician practices’16 has yet to be achieved in Louisiana. Nascent efforts are underway at the state and regional levels. Ideally, a public health informatics solution such as LaPHIE should reside within the infrastructure of a formalized HIE as the broker which could ‘serve up’ LaPHIE logic and CDS components on identiﬁed patients. LSU HCSD and OPH have built a system to address the issues of linkage and retention in care for persons with HIV which now can be customized to address other public health issues. The future system evolution will allow this approach to be scaled to a larger population base as disparate healthcare providers join a state or regional HIE and are identiﬁed as targets for this strategy. CONCLUSION The LaPHIE partnership has emerged as an example of how public health agencies and healthcare delivery organizations can share information to improve patient care and protect popula- tion health. Healthcare providers, as well as affected patients, have embraced the importance of LaPHIE in addressing the HIV epidemic in Louisiana. This innovative use of HIE is a critical step in curtailing the spread of infectious diseases and holds promise for extension to other providers, locations, and diseases. As of this writing, alerts for persons in need of tuberculosis follow-up have been implemented with similar acceptability and positive impact as those for HIV. While the exchange connects one IDN and the State’s public health authority, the project team is currently developing an extensible platform for replica- bility of the LaPHIE components within a private IDN in Louisiana. Subsequently, this EMR vendor-independent platform could be used by multiple healthcare providers and public health entities. Acknowledgments The authors thank staff members of the Louisiana Ofﬁce of Public Health (STD/HIV and tuberculosis programs), the Louisiana State University (LSU) Health Care Services Division, the LSU Health Sciences Center, the LSU School of Public Health, and the Louisiana Public Health Institute who contributed conceptual, technical, and data management support for the Louisiana Public Health Information Exchange. 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