Pulmonary Tuberculosis in the Elderly confirm that mortality due to pulmonary TB is significant- ly higher in the elderly than in the young. In conclusion, this study showed that elderly patients with pulmonary TB are more likely to present with non-specific symptoms and atypical radiographic findings. Moreover, we found a higher frequency of underlying disease, a higher inci- dence of adverse drug reactions, and higher TB-related mor- tality in elderly TB patients. However, no difference was ob- served between young and old patients with respect to spu- tum AFB detection rates. REFERENCES 1. Ministry of Health and Social Affairs and Korean National Tuber- culosis Association. Report on the tuberculosis prevalence survey in Korea 1965. 2. Ministry of Health and Welfare and Korean National Tuberculosis Association. Report on the seventh tuberculosis prevalence survey in Korea 1995. 3. Stead WW, Dutt AK. Tuberculosis in elderly persons. Annu Rev Med 1991; 42: 267-76. 4. Dutt AK, Stead WW. Tuberculosis in the elderly. Med Clin North Am 1993; 77: 1353-68. 5. Perez-Guzman C, Vargas MH, Torres-Cruz A, Villarreal-Velarde H. Does aging modify pulmonary tuberculosis? A meta-analytical review. Chest 1999; 116: 961-7. 6. Alvarez S, Shell C, Berk SL. Pulmonary tuberculosis in elderly men. Am J Med 1987; 82: 602-6. 7. Korzeniewska-Kosela M, Krysl J, Muller N, Black W, Allen E, Fitz- Gerald JM. Tuberculosis in young adults and the elderly. A prospec- tive comparison study. Chest 1994; 106: 28-32. 8. Umeki S. Comparison of younger and elderly patients with pulmonary tuberculosis. Respiration 1989; 55: 75-83. 9. Liaw YS, Yang PC, Yu CJ, Wu ZG, Chang DB, Lee LN, Kuo SH, Luh KT. Clinical spectrum of tuberculosis in older patients. J Am Geriatr Soc 1995; 43: 256-60. 10. Perez-Guzman C, Torres-Cruz A, Villarreal-Velarde H, Vargas MH. Progressive age-related changes in pulmonary tuberculosis images and the effect of diabetes. Am J Respir Crit Care Med 2000; 162: 1738-40. 11. Chan CH, Woo J, Or KK, Chan RC, Cheung W. The effect of age on the presentation of patients with tuberculosis. Tuber Lung Dis 1995; 76: 290-4. 12. Schaberg T, Rebhan K, Lode H. Risk factors for side-effects of iso- niazid, rifampin and pyrazinamide in patients hospitalized for pul- monary tuberculosis. Eur Respir J 1996; 9: 2026-30. 13. Yee D, Valiquette C, Pelletier M, Parisien I, Rocher I, Menzies D. Incidence of serious side effects from first-line antituberculosis drugs among patients treated for active tuberculosis. Am J Respir Crit Care Med 2003; 167: 1472-7. 14. Counsell SR, Tan JS, Dittus RS. Unsuspected pulmonary tubercu- losis in a community teaching hospital. Arch Intern Med 1989; 149: 1274-8. 789 15. Van den Brande P, Vijgen J, Demedts M. Clinical spectrum of pul- monary tuberculosis in older patients: comparison with younger patients. J Gerontol 1991; 46: M204-9. 16. Morris CD. Pulmonary tuberculosis in the elderly: a different dis- ease? Thorax 1990; 45: 912-3. 17. Katz I, Rosenthal T, Michaeli D. Undiagnosed tuberculosis in hos- pitalized patients. Chest 1985; 87: 770-4. 18. Rocha M, Pereira S, Barros H, Seabra J. Does pulmonary tubercu- losis change with aging? Int J Tuberc Lung Dis 1997; 1: 147-51. 19. Van den Brande P, Vernies T, Verwerft J, Van Bleyenber R, Van- hoenacker F, Demedts M. Impact of age and radiographic presen- tation on the presumptive diagnosis of pulmonary tuberculosis. Respir Med 2002; 96: 979-83. 20. Lee JH, Hwangbo B, Yoo CG, Lee CT, Han SK, Shim YS, Chung HS. Clinical features of pulmonary tuberculosis in the elderly. Tuberc Respir Dis 2001; 51: 334-45. 21. Dahmash NS, Fayed DF, Chowdhury MN, Arora SC. Diagnostic challenge of tuberculosis of the elderly in hospital: experience at a university hospital in Saudi Arabia. J Infect 1995; 31: 93-7. 22. Morris CD. Sputum examination in the screening and diagnosis of pulmonary tuberculosis in the elderly. Q J Med 1991; 81: 999-1004. 23. Grzybowski S, Allen EA, Black WA, Chao CW, Enarson DA, Isaac- Renton JL, Peck SH, Xie HJ. Inner-city survey for tuberculosis: evalu- ation of diagnostic methods. Am Rev Respir Dis 1987; 135: 1311-5. 24. Mackay AD, Cole RB. The problems of tuberculosis in the elderly. Q J Med 1984; 53: 497-510. 25. Patel YR, Mehta JB, Harvill L, Gateley K. Flexible bronchoscopy as a diagnostic tool in the evaluation of pulmonary tuberculosis in an elderly population. J Am Geriatr Soc 1993; 41: 629-32. 26. Teale C, Goldman JM, Pearson SB. The association of age with the presentation and outcome of tuberculosis: a five-year survey. Age Ageing 1993; 22: 289-93. 27. Ungo JR, Jones D, Ashkin D, Hollander ES, Bernstein D, Albanese AP, Pitchenik AE. Antituberculosis drug-induced hepatotoxicity. Am J Respir Crit Care Med 1998; 157: 1871-6. 28. Blumberg HM, Barman WJ, Chaisson RE, Daley CL, Etkind SC, Friedman LN, Fujiwara P, Grzemska M, Hopewell PC, Iseman MD, Jasemer RM, Koppaka V, Menzies RI, O’Brien RJ, Reves RR, Rci- chman LB, Simone PM, Starke JR, Verhon AA; American Thoracic Society, Centers for Disease Control and Prevention and the Infectious Diseases Society. American Thoraic Society/Centers for Disease Con- trol and Prevention/Infections Diseases Society of American: treat- ment of tuberculosis. Am J Respir Crit Care Med 2003; 167: 603-62. 29. Sharma SK, Balamurugan A, Saha PK, Pandey RM, Mehra NK. Eval- uation of clinical and immunogenetic risk factors for the develop- ment of hepatotoxicity during antituberculosis treatment. Am J Respir Crit Care Med 2002; 166: 916-9. 30. Fernandez-Villar A, Sopena B, Fernandez-Villar J, Vazquez-Gallar- do R, Ulloa F, Leiro V, Mosteiro M, Pineiro L. The influence of risk factors on the severity of anti-tuberculosis drug-induced hepatotoxi- city. Int J Tuberc Lung Dis 2004; 8: 1499-505. 31. Van den Brande P, Van Steenbergen W, Vervoort G, Demedts M. Aging and hepatotoxicity of isoniazid and rifampin in pulmonary tuberculosis. Am J Respir Crit Care Med 1995; 152: 1705-8.