van Essen et al. Mefloquine induced motor deficits clinical relevance. For example, the use of mefloquine may limit the speed and capacity to rehabilitate motor functions after traumatic injuries. Moreover, knowledge of this effect is also relevant for civil and military organizations that detach people to malaria endemic regions where they have to rely heavily on fine-tuning their motor skills or learn new motor skills. Therefore, this adverse effect should be further investigated and recognized by clinicians. stmgdelwonkca We are grateful for the contribution of the participants. We thank the nurses of the Travel Clinic in Rotterdam for their assistance during the recruitment of the volunteers. We also acknowledge the help of Dr. A. Smit and J. Willems with the eye-blink experi- ments. 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