Int. J. Environ. Res. Public Health 2010, 7 1888 44. Ji, D.; Gilpin, N.W.; Richardson, H.N.; Rivier, C.L.; Koob, G.F., Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats. Behav. Pharmacol. 2008, 19, 1–12. 45. Anton, R.F.; Oroszi, G.; O'Malley, S.; Couper, D.; Swift, R.; Pettinati, H.; Goldman, D. An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: Results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Arch. Gen. Psychiatry 2008, 65, 135–144. 46. Anton, R.F.; Myrick, H.; Baros, A.M.; Latham, P.K.; Randall, P.K.; Wright, T.M.; Stewart, S.H.; Waid, R.; Malcolm, R. Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms. J. Clin. Psychopharmacol. 2009, 29, 334–342. 47. Newton, B.W.; Russell, W.K.; Russell, D.H.; Ramaiah, S.K.; Jayaraman, A. Liver proteome analysis in a rodent model of alcoholic steatosis. J. Proteome. Res. 2009, 8, 1663–1671. 48. Anton, R.F.; O'Malley, S.S.; Ciraulo, D.A.; Cisler, R.A.; Couper, D.; Donovan, D.M.; Gastfriend, D.R.; Hosking, J.D.; Johnson, B.A.; LoCastro, J.S.; Longabaugh, R.; Mason, B.J.; Mattson, M.E.; Miller, W.R.; Pettinati, H.M.; Randall, C.L.; Swift, R.; Weiss, R.D.; Williams, L.D.; Zweben, A. Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: A randomized controlled trial. JAMA 2006, 295, 2003–2017. 49. Groh, D.R.; Jason, L.A.; Keys, C.B. Social network variables in alcoholics anonymous: A literature review. Clin. Psychol. Rev. 2008, 28, 430–450. © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).