CLINICS 2012;67(7):853-854 CASE REPORT DOI:10.6061/clinics/2012(07)25 Giant obstructive left atrial myxoma resembling mitral valve stenosis Solange Desire´ e Avakian, Julio Yoshio Takada, Antonio de Padua Mansur Hospital das Clinicas da Faculdade de Medicina da Universidade de Sa˜ o Paulo Medical, Heart Institute (InCor), S a˜o Paulo/SP, Brazil. Email: apmansur@usp.br Tel.: 55 11 2661-5387 INTRODUCTION Primary tumors of the heart are rare, with an incidence between 0.0017% and 0.19% in unselected patients at autopsy. Approximately 75% of the tumors are benign, and nearly half of them are myxomas (1). Atrial myxoma is the most common benign cardiac neoplasm, and its origin has been ascribed to a multipotential mesenchymal cell (2). Myxomas commonly occur between the third and sixth decades of life and are three times more frequent in women (3). There are two distinctive forms of the tumors: solid and ovoid myxomas and soft and papillary myxomas. Solid tumors are more likely to present with symptoms of congestive heart failure (CHF), while papillary tumors are more likely to embolize to the cerebral and other peripheral vessels (4). At the time of diagnosis, 92% of the patients have symptoms of CHF (5). Atrial myxoma may mimic valvular heart disease, cardiac insufficiency, cardiomegaly, bacterial endocarditis, disturbances of ventricular and supraventri- cular rhythm, syncope, and systemic or pulmonary embo- lism (3). The purpose of this paper is to present a case report of atrial myxoma mimicking severe mitral valve stenosis at cardiac auscultation and the importance of echocardiograpy in the diagnosis. CASE DESCRIPTION A 77-year-old Caucasian man presented at the Emergency Care Unit with a six-month history of congestive heart failure and in funcional class III, according to the New York Heart Association (NYHA) criteria. He had no previous history of diabetes, arterial hypertension, or ischemic co- ronary disease. The physical examination disclosed dis- tended neck veins, rales at the lung base, and hepatomegaly. Cardiac auscultation revealed a loud first heart sound and diastolic rumble resembling mitral valve stenosis. Chest radiography showed a normal cardiac silhouette image, enlarged hilar shadows and moderate right-sided pleural effusion. The electrocardiogram showed a regular sinus rhythm with a nonspecific repolarization alteration. The transthoracic echocardiogram showed an image of a large pediculate mass of 5.5 mm64.0 mm in the left atrium in his greater diameters, restricting transmitral diastolic blood Copyright 2012 CLINICS – This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non- commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. No potential conflict of interest was reported. 853 flow, and an atrium-ventricular pressure gradient of 11 mmHg (Figure 1). This mass was attached to the inferior edge of the fossa ovalis. Left ventricular function was normal, and the right ventricular diameter was 3.2 cm. His systolic pulmonary artery pressure was 100 mmHg. The patient was referred for cardiac surgery. The adopted tech- nique was a biatrial approach. The intraoperative findings included a mass, and anatomopathologic analysis confirmed that it was an atrial myxoma. Two days after surgery, an echodopplercardiogram showed an important reduction in systolic pulmonary artery pressure to 30 mmHg. Five years later, an echocardiogram showed no mass in the left atrial chamber. DISCUSSION This case report showed an atrial myxoma mimicking mitral valve stenosis. The diagnosis was made by echo- cardiogram, which disclosed a huge mass obstructing the left atrial blood flow. Heart valve disease is one of the differential diagnoses of atrial myxomas. The clinical findings of cardiac tumors are characterized by the triad of embolism, intracardiac obstruction, and constitutional findings. Congestive heart failure is the most common clinical presentation, followed by neurologic and syste- mic embolic events. Embolic events more frequently affect the cerebral arteries, including the retinal arteries. Embolization into visceral, renal, or coronary arteries has also been reported and can affect nearly 29% of patients (3). Although the large majority of myxomatous emboli are cerebral, it is possible for atrial myxomas to embolize and implant in other locations in the visceral and peripheral arterial circulation. Ectopic myxoma implants have been described in other unusual locations, including the skin, the skeleton, and the small bowel. Intracardiac obstruction with impaired filling of the left or right ventricle causes subsequent dyspnea, recurrent pulmonary edema, right- heart failure or even syncope or sudden death (6). Three fourths of myxomas are located in the left atrium (7). General or constitutional manifestations, such as fatigue, fever, weight loss, night sweats, arthralgia, and laboratory abnormalities, such as elevation of C-reactive protein, anemia, and the erythrocyte sedimentation rate, can also occur. Mitral valve obstruction caused by atrial myxoma repre- sents an important hemodynamic consequence leading to symptoms of congestive heart failure, pulmonary hyperten- sion, syncope, and sudden death. Clinicopathologic correla- tions showed that mitral stenotic effects occurred when the tumor diameter exceeded 5 cm (8). Echodopplercardiography