Int. J. Environ. Res. Public Health 2010, 7 1886 12. Strat, Y.L.; Ramoz, N.; Schumann, G.; Gorwood, P. Molecular genetics of alcohol dependence and related endophenotypes. Curr. Genomics. 2008, 9, 444–451. 13. Noble, E.P. The D2 dopamine receptor gene: A review of association studies in alcoholism and phenotypes. Alcohol 1998, 16, 33–45. 14. Polich, J.; Bloom, F.E. P300, alcoholism heritability, and stimulus modality. Alcohol 1999, 17, 149–156. 15. Vaughn, M.G.; Beaver, K.M.; DeLisi, M.; Howard, M.O.; Perron, B.E. Dopamine D4 receptor gene exon III polymorphism associated with binge drinking attitudinal phenotype. Alcohol 2009, 43, 179–184. 16. Namkoong, K.; Cheon, K.A.; Kim, J.W.; Jun, J.Y.; Lee, J.Y. Association study of dopamine D2, D4 receptor gene, GABAA receptor beta subunit gene, serotonin transporter gene polymorphism with children of alcoholics in Korea: a preliminary study. Alcohol 2008, 42, 77–81. 17. Wu, D.; Cederbaum, A.I. Alcohol, oxidative stress, and free radical damage. Alcohol. Res. Health 2003, 27, 277–284. 18. Lu, Y.; Cederbaum, A.I. CYP2E1 and oxidative liver injury by alcohol. Free Radic. Biol. Med. 2008, 44, 723–738. 19. Bousquet-Dubouch, M.P.; Nguen, S.; Bouyssie, D.; Burlet-Schiltz, O.; French, S. W.; Monsarrat, B.; Bardag-Gorce, F. Chronic ethanol feeding affects proteasome-interacting proteins. Proteomics 2009, 9, 3609–3622. 20. Crossley, I.R.; Neuberger, J.; Davis, M.; Williams, R.; Eddleston, A.L. Ethanol metabolism in the generation of new antigenic determinants on liver cells. Gut 1986, 27, 186–189. 21. Cubero, F.J.; Urtasun, R.; Nieto, N. Alcohol and liver fibrosis. Semin. Liver Dis. 2009, 29, 211–221. 22. Cahill, A.; Cunningham, C.C.; Adachi, M.; Ishii, H.; Bailey, S.M.; Fromenty, B.; Davies, A. Effects of alcohol and oxidative stress on liver pathology: the role of the mitochondrion. Alcohol. Clin. Exp. Res. 2002, 26, 907–915. 23. Gyamfi, M.A.; Damjanov, I.; French, S.; Wan, Y.J. The pathogenesis of ethanol versus methionine and choline deficient diet-induced liver injury. Biochem. Pharmacol. 2008, 75, 981–995. 24. Thakur, V.; Pritchard, M.T.; McMullen, M.R.; Wang, Q.; Nagy, L.E. Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells: role of increased reactive oxygen in LPS-stimulated ERK1/2 activation and TNF-alpha production. J. Leukoc. Biol. 2006, 79, 1348–1356. 25. Butura, A.; Nilsson, K.; Morgan, K.; Morgan, T.R.; French, S.W.; Johansson, I.; Schuppe-Koistinen, I.; Ingelman-Sundberg, M. The impact of CYP2E1 on the development of alcoholic liver disease as studied in a transgenic mouse model. J. Hepatol. 2009, 50, 572–583. 26. Qin, L.; He, J.; Hanes, R.N.; Pluzarev, O.; Hong, J.S.; Crews, F.T. Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment. J. Neuroinflammation 2008, 5, 10.