Urologic Surgery in Renal Transplant Recipients DISCUSSION Renal transplantation is the best available therapy for most patients with end-stage renal disease. The pre-transplantation goal of the urologist is to optimize the condition of the uri- nary tract, which should be sterile, continent, and compliant before donor kidney transplantation (2). Transplantation candidates may have undetected urologic abnormalities, and clinical symptoms that are minimal pre- operatively can be exacerbated after the restoration of renal function by successful transplantation. If correction is consid- ered, it is recommended that all anomalies should be repaired before transplantation to allow for proper healing before the patient is placed on immunosuppression (3). Many reports indicate that an abnormal lower urinary bladder or posterior urethral valves are no longer a contraindication to renal trans- plantation, as patients with lower urinary tract anomalies have previously been considered poor candidates for renal transplan- tation. However, newer techniques of diagnosis and reconst- ructive urologic surgery have extended the indications and improved the success rate of renal transplantation in these patients (4-6). Infection sources should be controlled to pre- vent a flare-up and possible septicemia that may occur after the initiation of immunosuppressive therapy with transplan- tation. In the present study, patients with VUR were correct- ed before transplantation, because they could incur septicemia during immunosuppressive therapy. The indications for bilateral nephrectomy in patients with autosomal dominant polycystic kidney disease are recurrent infection, bleeding into cysts, and a huge kidney that inter- feres with pulmonary function (7). However, Stiasny et al. (8) found that overall patient and graft survival rates did not differ between those with and without a polycystic kidney. As uri- nary tract infection and lethal septicemia were the leading complications in patients with a polycystic kidney, careful monitoring for infections is important during the post-trans- plant follow-up. Four of 7 patients with polycystic kidney in our cases had bleeding into cysts and an extremely enlarged polycystic kidney; therefore, we performed bilateral nephrec- tomy. Restoration of the urinary tract by urinary diversion, or aug- mentation enterocystoplasty should be also considered in pa- tients with neurogenic bladder or in those with a contracted bladder (9, 10). Natarajan et al. (11) reported successful pregnancy in pati- ents with urinary diversion. In our study, one patient achieved a successful vaginal delivery. She underwent ileal urinary diver- sion at the time of her renal transplantation. Reinberg et al. (12) recommended that nephrectomy should be performed 6 weeks to 3 months before transplantation, but not before the urethral procedure, to prevent dry urethral syndrome. We performed urologic surgery successfully 2.9 months before transplantation and obtained good result. How- ever, perioperative morbidity and mortality rates are elevated 77 in patients with uremia. Cardiovascular disease is the most common cause of death in patients with renal disease (13) and bleeding tendency is also another significant risk factor. The most common hemorrhagic manifestations in uremia are pro- longed bleeding from operation site, and this kind bleeding is exacerbated by anticoagulation therapy during hemodi- alysis (14). In the present study, two patients expired due to postoperative bleeding. To reduce mortality and morbidity, increased bleeding related to uremic platelet dysfunction can be managed by the administration of desmopressin, cryopre- cipitate, or estrogens, and by avoiding the use of medication with antiplatelets close to the time of surgery. Hyperkalemia can be temporarily improved by the intravenous administra- tion of an insulin-dextrose combination or bicarbonate, and polystyrene binding resins or dialysis can remove excess potas- sium stores (15). Spontaneous renal allograft rupture has been occasionally reported (16). However, the rupture of an end-stage native kidney is relatively rare. Piccoli et al. (17) reported sponta- neous renal rupture in a patient with acquired cystic kidney disease (ACKD) on hemodialysis. We performed emergency nephrectomy on a patient with a ruptured native kidney 122 months after transplantation. However, this is a life-threaten- ing condition, and many recipients have ACKD. Therefore, close follow-up is needed for these patients. TURP can be performed before or after renal transplantation. However, Shenaky (18) reported that TURP in the patient with BPH might lead to bladder neck contracture or urethral scarring with recurrent stenosis, if it is performed before the reestab- lishment of urine flow by transplantation. Reinberg et al. (19) found that TURP can be safely performed immediately after renal transplantation only if; urine is sterile, antibiotics and steroids are carefully administered perioperatively, low-gravity irrigation is used, and hemostasis is meticulous. We performed TURP 2 months after renal transplantation without any inci- dent, although renal cell carcinoma was detected 25 months after transplantation in a single patient. Surgery was not per- formed in this case because of patient refusal. From the results of the present study, we conclude that the major reasons for urologic surgery in recipients are polycystic kidney disease, VUR, and dysfunctional voiding disorders. Surgical correction, with the exception of urethral surgery, should be performed at least 3 months before renal transplan- tation. However, it must be recognized that patients with ure- mia are vulnerable to surgical complications due to a bleeding tendency, although urologic surgery was not found to influence graft survival. We also conclude that more intensive long-term urologic follow-up must be undertaken for recipients. ACKNOWLEDGEMENT This work was supported by grant No. R13-2002-020- 01001-0 from the Korean Science & Engineering Foundation.