D442 Nucleic Acids Research, 2007, Vol. 35, Database issue as electronically inferred from InterPro domains that are signatures of the tubulin superfamily. The inset GBrowse frame shows some of the annotation information and results of some computational analyses. Each of these, when clicked, brings up the corresponding sequence feature page. Match scores appear when the mouse hovers over the feature. The match page for Tetrahy- mena best reciprocal matches contains a link (at the top of the left sidebar) to the corresponding gene page in the Tetrahy- mena Genome Database (22). Tetrahymena thermophila, another ciliate, is the closest relative to Paramecium with a sequenced genome (23); however, the two organisms are separated by 500 MY and orthologous proteins share only 40% amino acid identity (14). The sidebar shows all related data in ParameciumDB, including external references to GenBank and PubMed as well as relationships to other sequence features including alleles and RNAi reagents. There is a computational analysis result for this gene, a paralog related by one of the series of whole genome duplications in the Paramecium lineage (14): eta-tubulin arose through duplication of an ancestral delta-tubulin gene. Allele page The allele page for the sm19-1 allele is reached by clicking on that allele’s name in the sidebar. An allele page (Figure 2) is similar to a gene page. The sidebar has the same layout; however, there is now data regarding pheno- types and stocks. The central panel shows that we are looking at a Sequence Feature of type ‘sequence_variant’, the Sequence Ontology term for allele. Three new categories now feature in the central panel. ‘Publications’ provides a link to NCBI with a PubMed query that brings up all of the relevant literature. ‘Heredity’ is used to distinguish Mendel- ian (micronuclear) heredity from non-Mendelian (macronu- clear) heredity. A box shows ‘genetic interactions’ and in this case both phenotypes observed for this allele at the non-permissive temperature are enhanced or suppressed by other alleles. Note that each phenotype is observed under Figure 2. A ParameciumDB allele page. This is the allele page for the allele sm19-1.