R e s e a r c h p a p e r 22. 23. 24. 25. 26. 27. Aylward EH, Sparks BF, Feild KM, et al. The onset and rate of striatal atrophy in preclinical Huntington’s disease. Neurology 2004;13:66–72. Paulsen JS, Zimbelman JL, Hinton SC, et al. An fMRI biomarker of early neuronal dysfunction in presymptomatic Huntington’s disease. Am J Neuroradiol 2004;25:1715–21. Reading SAJ, Dziorny AC, Peroutka LA, et al. Functional brain changes in pre- symptomatic Huntington’s disease. Ann Neurol 2004;55:879–83. Cepeda C, Ariano MA, Calvert CR, et al. NMDA receptor function in mouse models of Huntington disease. J Neurosci Res 2001;66:525–39. Unified Huntington’s Disease Rating Scale: reliability and consistency. Huntington Study Group. Mov Disord 1996;11:136–42. Paulsen JS, Hayden M, Stout JC, et al. Preparing for preventive clinical trials: the Predict-HD study. Arch Neurol 2006;63:883–90. 28. 29. 30. 31. 32. 33. Reitan RM. Manual for administration and scoring of the Halstead–Reitan of neuropsychological test battery for adults and children. Tucson: Neuropsychology Press, 1979. Brandt J. The Hopkins verbal learning test: development of a new memory test with six equivalent forms. Clin Neuropsychol 1991;5:125–42. Doty RL, Shaman P, Kimmelman CP, et al. University of Pennsylvania Smell Identification Test: a rapid quantitative olfactory function test for the clinic. Laryngoscope 1984;94:176–8. Harrell FE. Regression modeling strategies. New York: Springer, 2001. Burzykowski T, Molenberghs G, Buyse M. The evaluation of surrogate endpoints. New York: Springer, 2005. Lange K. Applied probability. New York: Springer, 2003. 4th Fred J Epstein International Symposium on New Horizons in Pediatric Neurology, Neurosurgery and Neurofibromatosis 15–19 March 2009, Eilat, Israel A symposium for paediatric neurologists, neurosurgeons, neuroradiologists, neuropathologists, neuro- oncologists, neurogeneticists, neuroscientists, perinatologists and paediatricians The symposium will provide an update in the diagnoses and management of diseases of the nervous system in infants and children that may be treated surgically. An emphasis will be placed on joint, rather than parallel sessions, with both neurological and neurosurgical approaches. The faculty is comprised of recognised leaders in their respective fields. Special attention will be given to controversial issues of common interest in patient management, new surgical-neuroradiological techniques and oncological options. The conference will be conducted in English. Conference organisers are: Shlomi Constantini, Israel; Shaul Harel, Israel; Rick Abbott, USA; Susan Bressman, USA; Kathy Epstein, USA; Roger J Packer, USA; Shlomo Shinnar, USA. For more information please contact the Secretariat: Target Conferences Ltd, PO Box 29041, Tel Aviv 61290, Israel; Tel: +972 3 5175150; Fax: +972 3 5175155; Email: newhorizons@targetconf.com; Website: www.fredhorizons.com. 880 J Neurol Neurosurg Psychiatry 2008;79:874–880. doi:10.1136/jnnp.2007.128728