Int. J. Environ. Res. Public Health 2010, 7 957 Broadly speaking, NF-κB-controlled pathways are relevant to many human diseases. NF-κB is chronically overexpressed in inflammatory diseases (arthritis, sepsis, asthma, among others). There is evidence for a critical role of NF-κB in carcinogenesis, and NF-κB is a key mediator of chemotherapy resistance, as well as having a major role in tumor development, particularly in its early phases [112]. Therefore, blocking NF-κB can inhibit tumor cell proliferation, increase their sensitivity to the action of anti-tumor agents or induce apoptosis. This emphasizes the importance of NF-κB inhibitors as immunotherapeutic agents for chronic inflammation and suggests that these reagents might prevent, or at least inhibit, chronic inflammation-associated tumorogenesis [113]. Therefore, the possibility of using external magnetic fields for the regulation of Rel/NF-κB/IκB expression by involving the magneto-sensitiveness of Cryptochromes looks promising. The transcription regulatory effects of magnetic fields can be manifested in many different ways. Correspondingly, their application in both prophylactic and therapeutic ways also calls for extensive research in this field. Success in this direction is already evident. For example, ELF EMF treatment has been used to stimulate endothelial cells proliferation, and in the activation of wound healing and angiogenesis. In these experiments, the stimulatory influence of ELF EMF on VEGF receptor 2 expression was demonstrated [105]. Exposure to ELF magnetic fields triggers the expression of cardiac lineage-promoting genes GATA-4 and Nkx-2.5 and enhanced prodynorphin gene expression in mouse embryonic stem cells [18]. These effects play a key role in cardiogenesis at the transcriptional level and cause a remarkable increase in the yield of embryonic stem cell-derived cardiomyocytes. 8. Conclusions We believe that the data presented here allows us to conclude that most living creatures and many types of cells can be sensitive to weak magnetic fields due to magnetosensitive proteins— Cryptochromes, which are important regulators of the major circadian transcriptional complex CLOCK/BMAL1 activity. The transcriptional repression function of CRY is apparently highly responsive to weak MF because of radical pairs, which periodically arise in the functionally active site of CRY and mediate the radical pair mechanism of magnetoreception. Thus, environmental exposure to EMFs can interact with fundamental biological processes in the body, confirming the possible bio-informational and bio-regulatory functions of electromagnetic radiation. The presented data also indicates the potential use of magnetic fields in modifying gene expression patterns and programs in different cell types, including stem cells, without the aid of gene transfer technologies. Thus, the proposed mechanism of the magnetic field’s bio-regulatory effects seems to offer new options and molecular targets for development of new biotechnological, therapeutic and prophylactic strategies, including those of epidemiological significance. Viruses are indispensable part of the evolution process machinery. They act both: as a factor of genomic diversity increase and as a natural selection factor. Taking into account a probable entrainment role of Solar activity fluctuations in regulation of genome expression and influenza epidemic cycles, we can suggest regulatory/entrainment role of the Solar cycles for Earth life (biosphere) microevolution. According to the Space Weather Prediction Center NOAA/SWPC, the next solar activity maximum is expected in the year 2013 [114]. Following the main idea of this review, it is suggested that from