220 (77.2) 61 (21.4) 4 (1.4) 65 (22.8) 246 (86.3) 38 (13.3) 1 (0.4) 39 (13.7) 156 (54.7) 104 (36.5) 25 (8.8) 129 (45.3) Genotype ERCC2 751 AA AC CC AC/CCb ERCC2 312 GG GA AA GA/AAc ERCC1 118 CC CT TT CT/TTd Group Cooking oil fume exposure Non exposure ERCC2 751 AA ERCC2 751 AC/CC Exposure ERCC2 751 AA ERCC2 751 AC/CC Fuel smoke exposure Non exposure ERCC2 751 AA ERCC2 751 AC/CC Exposure ERCC2 751 AA ERCC2 751 AC/CC Journal of Experimental & Clinical Cancer Research 2009, 28:153 http://www.jeccr.com/content/28/1/153 Table 2: ERCC2 751, 312 and ERCC1 188 polymorphisms and lung adenocarcinoma risk Cases n (%) Controls n (%) Abbreviation: OR, odds ratio; CI, confidence interval. aORs were calculated by unconditional logistic regression and adjusted for age and cooking oil fume. bOR and P value were calculated compared with wild genotype(AA) of ERCC2 751 polymorphism. cOR and P value were calculated compared with wild genotype(GG) of ERCC2 312 polymorphism. dOR and P value were calculated compared with wild genotype(CC) of ERCC1 118 polymorphism. eOR and P value for this genotype could not be calculated. fume exposure on lung adenocarcinoma using a logistic regression model. However, no evidence of significant gene-environment interaction was found (data not shown). We analyzed haplotypes using SHEsis program platform (Table 4). The three SNPs were in linkage disequilibrium in this study population. The haplotypes were composed of 3 coding SNPs (cSNPs) that locate across 68.734 kb on 19q13.3 region. Of 8 possible haplotypes, only 3 had fre- quencies of > 0.03 among both cases and controls and were included in the haplotype analysis. Three possible haplotypes represented 91.7% of the chromosomes for the cases and 94.0% for the controls. There was a statisti- cally significant difference in the overall haplotype distri- bution between cases and controls (global test P < 0.001). Table 3: ERCC2 751 SNP in relation to risk of lung adenocarcinoma, stratified by environmental exposures Cases n (%) Controls n (%) OR [95%CI]* P value 242 (84.9) 40 (14.0) 3 (1.1) 43 (15.1) 255 (89.5) 30 (10.5) 0 (0.0) 30 (10.5) 176 (61.8) 96 (33.6) 13 (4.6) 109 (38.2) 137 (75.7) 44 (24.3) 83 (79.8) 21 (20.2) 150 (74.6) 51 (25.4) 70 (83.3) 14 (16.7) Abbreviation: OR, odds ratio; CI, confidence interval. *ORs and 95%CIs were calculated by logistic regression, with the ERCC2 751 wild genotype (AA) as the reference group. ORs were adjusted for age. Page 4 of 7 (page number not for citation purposes) OR [95%CI]a 1.00 1.66 [1.07-2.59] 1.28 [0.28-5.86] 1.64 [1.06-2.52] 1.00 1.30 [0.78-2.17] --e 1.33 [0.80-2.21] 1.00 1.19 [0.84-1.70] 2.01 [0.99-4.10] 1.29 [0.92-1.81] P value -- 0.024 0.751 0.025 -- 0.317 -- 0.275 -- 0.334 0.054 0.139 181 (86.2) 29 (13.8) 61 (81.3) 14 (18.7) 182 (87.9) 25 (12.1) 60 (76.9) 18 (23.1) 1.00 1.98 [1.18-3.32] 1.00 1.03 [0.48-2.21] 1.00 2.47 [1.46-4.18] 1.00 0.65 [0.30-1.41] -- 0.010 -- 0.940 -- 0.001 -- 0.270