Histochem Cell Biol (2012) 138:861–879 Saunders NR, Ek CJ, Habgood MD, Dziegielewska KM (2008) Barriers in the brain: a renaissance? Trends Neurosci 31:279– 286 Saunders NR, Liddelow SA, Dziegielewska KM (2012) Barrier mechanisms in the developing brain. Front Neuropharmacol 3:46 [Epub 29 Mar 2012] Schmitt C, Strazielle N, Richaud P, Bouron A, Ghersi-Egea JF (2011) Active transport at the blood–CSF barrier contributes to manganese inﬂux into the brain. J Neurochem 117:747–756 Shuangshoti S, Netsky MG (1966) Histogenesis of choroid plexus in man. Am J Anat 118:283–316 Stolp HB, Turnquist C, Dziegielewska KM, Saunders NR, Anthony DC, Molnar Z (2011) Reduced ventricular proliferation in the foetal cortex following maternal inﬂammation in the mouse. Brain 134:3236–3248 Strazielle N, Ghersi-Egea JF (1999) Demonstration of a coupled metabolism-efﬂux process at the choroid plexus as a mechanism of brain protection toward xenobiotics. J Neurosci 19:6275–6289 Strazielle N, Ghersi-Egea JF (2000) Choroid plexus in the central nervous system: biology and physiopathology. J Neuropathol Exp Neurol 59:561–574 Umeda K, Ikenouchi J, Katahira-Tayama S, Furuse K, Sasaki H, Nakayama M, Matsui T, Tsukita S, Furuse M, Tsukita S (2006) ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation. Cell 126:741– 754 Van Itallie CM, Rogan S, Yu A, Vidal LS, Holmes J, Anderson JM (2006) Two splice variants of claudin-10 in the kidney create paracellular pores with different ion selectivities. Am J Physiol Renal Physiol 291:F1288–F1299 Van Itallie CM, Holmes J, Bridges A, Gookin JL, Coccaro MR, Proctor W, Colegio OR, Anderson JM (2008) The density of 879 small tight junction pores varies among cell types and is increased by expression of claudin-2. J Cell Sci 121:298–305 Virgintino D, Errede M, Robertson D, Capobianco C, Girolamo F, Vimercati A, Bertossi M, Roncali L (2004) Immunolocalization of tight junction proteins in the adult and developing human brain. Histochem Cell Biol 122:51–59 Wilkinson J, Radkowski M, Laskus T (2009) Hepatitis C virus neuroinvasion: identiﬁcation of infected cells. J Virol 83:1312– 1319 Wolburg H, Wolburg-Buchholz K, Liebner S, Engelhardt B (2001) Claudin-1, claudin-2 and claudin-11 are present in tight junctions of choroid plexus epithelium of the mouse. Neurosci Lett 307:77–80 Wolburg H, Wolburg-Buchholz K, Kraus J, Rascher-Eggstein G, Liebner S, Hamm S, Duffner F, Grote EH, Risau W, Engelhardt B (2003) Localization of claudin-3 in tight junctions of the blood–brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multi- forme. Acta Neuropathol 105:586–592 Yu AS (2009) Molecular basis for cation selectivity in claudin-2- based pores. Ann N Y Acad Sci 1165:53–57 Yu AS, Cheng MH, Angelow S, Gunzel D, Kanzawa SA, Schnee- berger EE, Fromm M, Coalson RD (2009) Molecular basis for cation selectivity in claudin-2-based paracellular pores: identi- ﬁcation of an electrostatic interaction site. J Gen Physiol 133:111–127 Zappaterra MW, Lehtinen MK (2012) The cerebrospinal ﬂuid: regulator of neurogenesis, behavior, and beyond. Cell Mol Life Sci [Epub ahead of print] Zheng A, Yuan F, Li Y, Zhu F, Hou P, Li J, Song X, Ding M, Deng H (2007) Claudin-6 and claudin-9 function as additional corecep- tors for hepatitis C virus. J Virol 81:12465–12471 123