Metal-rich air particles and histone modifications epidemiologic studies in Utah Valley residents. Environ Health Perspect 109(suppl 3):395–403. Fang GC, Lin SJ, Lee JF, Chang CC. 2009. A study of particulates and metallic element concentrations in temple. Toxicol Ind Health 25(2):93–100. Feinberg AP, Tycko B. 2004. The history of cancer epigenetics. Nat Rev Cancer 4(2):143–153. Frampton MW, Ghio AJ, Samet JM, Carson JL, Carter JD, Devlin RB. 1999. Effects of aqueous extracts of PM10 filters from the Utah Valley on human airway epithelial cells. Am J Physiol 277(5 pt 1):L960–L967. Franklin M, Koutrakis P, Schwartz P. 2008. The role of particle composition on the association between PM2.5 and mor- tality. Epidemiology 19(5):680–689. Ghio AJ, Devlin RB. 2001. Inflammatory lung injury after bron- chial instillation of air pollution particles. Am J Respir Crit Care Med 164(4):704–708. Gibb HJ, Lees PS, Pinsky PF, Rooney BC. 2000. Lung cancer among workers in chromium chemical production. Am J Ind Med 38(2):115–126. Gilmour PS, Rahman I, Donaldson K, MacNee W. 2003. Histone acetylation regulates epithelial IL-8 release mediated by oxidative stress from environmental particles. Am J Physiol Lung Cell Mol Physiol 284(3):L533–L540. Gomes J, Lloyd O, Norman N. 2002. The health of the workers in a rapidly developing country: effects of occupational expo- sure to noise and heat. Occup Med (Lond) 52(3):121–128. International Agency for Research on Cancer. 1987. Overall evaluations of carcinogenicity: an updating of IARC Monographs volumes 1 to 42. Monogr Eval Carcinog Risks Hum Suppl 7:1–440. Jensen TJ, Wozniak RJ, Eblin KE, Wnek SM, Gandolfi AJ, Futscher BW. 2009. Epigenetic mediated transcriptional activation of WNT5A participates in arsenical-associ- ated malignant transformation. Toxicol Appl Pharmacol 235(1):39–46. Ke Q, Davidson T, Chen H, Kluz T, Costa M. 2006. Alterations of histone modifications and transgene silencing by nickel chloride. Carcinogenesis 27(7):1481–1488. Kuo HW, Chang CL, Liang WM, Chung BC. 1999. Respiratory abnormalities among male foundry workers in central Taiwan. Occup Med (Lond) 49(8):499–505. Lewis S, Mason C, Srna J. 1992. Carbon monoxide exposure in blast furnace workers. Aust J Public Health 16(3):262–268. MacArthur AC, Le ND, Fang R, Band PR. 2009. Identification of occupational cancer risk in British Columbia: a population- based case-control study of 2,998 lung cancers by histo- pathological subtype. Am J Ind Med 52(3):221–232. MacNee W, Donaldson K. 2003. Mechanism of lung injury caused by PM10 and ultrafine particles with special refer- ence to COPD. Eur Respir J Suppl 40:47s–51s. Pavanello S, Bollati V, Pesatori AC, Kapka L, Bolognesi C, Bertazzi PA, et al. 2009. Global and gene-specific promoter methylation changes are related to anti-B[a]PDE-DNA adduct levels and influence micronuclei levels in poly- cyclic aromatic hydrocarbon-exposed individuals. Int J Cancer 125(7):1692–1697. Pearce N, Checkoway H, Kriebel D. 2007. Bias in occupational epidemiology studies. Occup Environ Med 64(8):562–568. Roller M. 2009. Carcinogenicity of inhaled nanoparticles. Inhal Toxicol 21(suppl 1):144–157. Roy AA, Baxla SP, Gupta T, Bandyopadhyaya R, Tripathi SN. 2009. Particles emitted from indoor combustion sources: size distribution measurement and chemical analysis. Inhal Toxicol 21(10):837–848. Salnikow K, Zhitkovich A. 2008. Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogen- esis: nickel, arsenic, and chromium. Chem Res Toxicol 21(1):28–44. Sun H, Zhou X, Chen H, Li Q, Costa M. 2009. Modulation of his- tone methylation and MLH1 gene silencing by hexavalent chromium. Toxicol Appl Pharmacol 237(3):258–266. Surralles J, Puerto S, Ramirez MJ, Creus A, Marcos R, Mullenders LH, et al. 1998. Links between chromatin struc- ture, DNA repair and chromosome fragility. Mutat Res 404(1–2):39–44. Tarantini L, Bonzini M, Apostoli P, Pegoraro V, Bollati V, Marinelli B, et al. 2009. Effects of particulate matter on genomic DNA methylation content and iNOS promoter methylation. Environ Health Perspect 117:217–222. Vijay Bhaskar B, Jeba Rajasekhar RV, Muthusubramanian P, Kesarkar AP. 2009. Ionic and heavy metal composition of respirable particulate in Madurai, India. Environ Monit Assess 164(1-4):323–336. Wang Z, Neuburg D, Li C, Su L, Kim JY, Chen JC, et al. 2005. Global gene expression profiling in whole-blood samples from individuals exposed to metal fumes. Environ Health Perspect 113:233–241. Wild P, Bourgkard E, Paris C. 2009. Lung cancer and exposure to metals: the epidemiological evidence. Methods Mol Biol 472:139–167. Yan C, Boyd DD. 2006. Histone H3 acetylation and H3 K4 methy- lation define distinct chromatin regions permissive for transgene expression. Mol Cell Biol 26(17):6357–6371. Yan Y, Kluz T, Zhang P, Chen HB, Costa M. 2003. Analysis of specific lysine histone H3 and H4 acetylation and methyla- tion status in clones of cells with a gene silenced by nickel exposure. Toxicol Appl Pharmacol 190(3):272–277. Zhou QX, Zhao XN, Xiao JP. 2009. Preconcentration of nickel and cadmium by TiO2 nanotubes as solid-phase extraction adsorbents coupled with flame atomic absorption spec- trometry. Talanta 77(5):1774–1777. Zhou X, Li Q, Arita A, Sun H, Costa M. 2009. Effects of nickel, chromate, and arsenite on histone 3 lysine methylation. Toxicol Appl Pharmacol 236(1):78–84. Zhou X, Sun H, Ellen TP, Chen H, Costa M. 2008. Arsenite alters global histone H3 methylation. Carcinogenesis 29(9):1831–1836. Zoroddu MA, Kowalik-Jankowska T, Kozlowski H, Molinari H, Salnikow K, Broday L, et al. 2000. Interaction of Ni(II) and Cu(II) with a metal binding sequence of histone H4: AKRHRK, a model of the H4 tail. Biochim Biophys Acta 1475(2):163–168. Zoroddu MA, Schinocca L, Kowalik-Jankowska T, Kozlowski H, Salnikow K, Costa M. 2002. Molecular mechanisms in nickel carcinogenesis: modeling Ni(II) binding site in his- tone H4. Environ Health Perspect 110(suppl 5):719–723. Environmental Health Perspectives • volume 119 | number 7 | July 2011 969