Functions of Lipids for Enhancement of Oral Bioavailability of Poorly Water-Soluble Drugs 725 [20] Porter CJH, Charman SA, Charman WN. Lymphatic transport of halofantrine in the triple cannulated anesthesized rat model: Effect of lipid vehicle dispersion. J Pharm Sci. 1996; 85: 351–356. http://dx.doi.org/10.1021/js950221g [21] Hauss DJ. Lipid-based systems for oral drug delivery: Enhancing the bioavailability of poorly water-soluble drugs. Am Pharm Rev. 2002; 5: 22–28. [22] Armstrong NA, James KC. Drug release from lipid-based dosage forms. II. Int J Pharm.1980; 6: 195–204. http://dx.doi.org/10.1016/0378-5173(80)90104-0 [23] Eccleston GM. Microemulsions. In: Swarbrick J, Boylan JC; eds. Encyclopedia of pharmaceutical technology. Vol 9, Marcel Dekker, New York, 1992: 375–421. [24] Attwood D. Microemulsions. In: Krueter J; ed. Colloidal Drug Delivery Systems. Marcel Dekker, New York, 1994: 31–71. [25] Swenson ES, Curatolo WJ. Intestinal permeability enhancement for proteins, peptides and other polar drugs: Mechanisms and potential toxicity. Adv Drug Deliv Rev.1992; 8: 39–92. http://dx.doi.org/10.1016/0169-409X(92)90015-I [26] Osborne DW, Middleton CA, Rogers RL. Alcohol-free microemulsions. J Dispersion Sci Technol. 1988; 9: 415–423. http://dx.doi.org/10.1080/01932698808943999 [27] Aungst BJ, Nguyen NH, Rogers NJ. Amphiphilic vehicles improve the oral bioavailability of a poorly soluble HIV protease inhibitor at high doses. Int J Pharm. 1997; 156: 79–88. http://dx.doi.org/10.1016/S0378-5173(97)00189-0 [28] Szuts EZ, Harosi FI. Solubility of retinoids in water. Arch Biochem Biophys.1991; 87: 297–304. http://dx.doi.org/10.1016/0003-9861(91)90482-X [29] Charman WN, Stella VJ. Estimating the maximal potential for intestinal lymphatic transport of lipophilic drug molecules. Int J Pharm. 1986; 34: 175–178. http://dx.doi.org/10.1016/0378-5173(86)90027-X [30] Dumanli I. Characterization of gelling phenomenon of a lipid-based formulation. Master Thesis, University of Rhode Island, 1998. [31] Chakrabarti S, Belpaire FM. Bioavailability of Phenytoin in lipid containing dosage forms in rats. J Pharm Pharmacol.1978; 30: 330–331. http://dx.doi.org/10.1111/j.2042-7158.1978.tb13247.x Sci Pharm. 2011; 79: 705–727