8 skeletal muscle hypertrophy and improved function,” Journal of Applied Physiology, vol. 64, no. 3, pp. 1038–1044, 1988. [48] F. C. Hagerman, S. J. Walsh, R. S. Staron et al., “Eﬀects of high-intensity resistance training on untrained older men. I. Strength, cardiovascular, and metabolic responses,” Journals of Gerontology Series A, vol. 55, no. 7, pp. B336–B346, 2000. [49] S. B. Votruba, M. A. Horvitz, and D. A. Schoeller, “The role of exercise in the treatment of obesity,” Nutrition, vol. 16, no. 3, pp. 179–188, 2000. [50] S. P. Messier, C. Legault, R. F. Loeser et al., “Does high weight loss in older adults with knee osteoarthritis aﬀect bone-on-bone joint loads and muscle forces during walking,” Osteoarthritis and Cartilage, vol. 19, pp. 272–280, 2011. [51] L. Fontana and S. Klein, “Aging, adiposity, and calorie re- striction,” Journal of the American Medical Association, vol. 297, no. 9, pp. 986–994, 2007. [52] S. B. Racette, E. P. Weiss, D. T. Villareal et al., “One year of caloric restriction in humans: feasibility and eﬀects on body composition and abdominal adipose tissue,” Journals of Gerontology Series A, vol. 61, no. 9, pp. 943–950, 2006. [53] L. K. Heilbronn, L. De Jonge, M. I. Frisard et al., “Eﬀect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial,” Journal of the American Medical Association, vol. 295, no. 13, pp. 1539–1548, 2006. [54] J. J. Avila, J. A. Gutierres, M. E. Sheehy, I. E. Lofgren, and M. J. Delmonico, “Eﬀect of moderate intensity resistance training during weight loss on body composition and physical performance in overweight older adults,” European Journal of Applied Physiology, vol. 109, no. 3, pp. 517–525, 2010. [55] D. T. Villareal, S. Chode, N. Parimi et al., “Weight loss, exercise, or both and physical function in obese older adults,” The New England Journal of Medicine, vol. 364, no. 13, pp. 1218–1229, 2011. [56] X. Z. He and D. W. Baker, “Body mass index, physical activity, and the risk of decline in overall health and physical functioning in late middle age,” American Journal of Public Health, vol. 94, no. 9, pp. 1567–1573, 2004. [57] M. M. Hillsdon, E. J. Brunner, J. M. Guralnik, and M. G. Marmot, “Prospective study of physical activity and physical function in early old age,” American Journal of Preventive Medicine, vol. 28, no. 3, pp. 245–250, 2005. [58] T. Manini, M. Marko, T. VanArnam et al., “Eﬃcacy of re- sistance and task-speciﬁc exercise in older adults who modify tasks of everyday life,” Journals of Gerontology Series A, vol. 62, no. 6, pp. 616–623, 2007. [59] K. R. Vincent, R. W. Braith, R. A. Feldman, H. E. Kallas, and D. T. Lowenthal, “Improved cardiorespiratory endurance following 6 months of resistance exercise in elderly men and women,” Archives of Internal Medicine, vol. 162, no. 6, pp. 673– 678, 2002. [60] M. Brown and J. O. Holloszy, “Eﬀects of walking, jogging and cycling on strength, ﬂexibility, speed and balance in 60- to 72- year olds,” Aging, vol. 5, no. 6, pp. 427–434, 1993. [61] S. L. Charette, L. McEvoy, G. Pyka et al., “Muscle hypertrophy response to resistance training in older women,” Journal of Applied Physiology, vol. 70, no. 5, pp. 1912–1916, 1991. [62] M. A. Fiatarone, E. C. Marks, N. D. Ryan, C. N. Meredith, L. A. Lipsitz, and W. J. Evans, “High-intensity strength training in nonagenarians. Eﬀects on skeletal muscle,” Journal of the American Medical Association, vol. 263, no. 22, pp. 3029–3034, 1990. Journal of Aging Research [63] A. Ferri, G. Scaglioni, M. Pousson, P. Capodaglio, J. Van Hoecke, and M. V. Narici, “Strength and power changes of the human plantar ﬂexors and knee extensors in response to resistance training in old age,” Acta Physiologica Scandinavica, vol. 177, no. 1, pp. 69–78, 2003. [64] R. U. Newton, K. Ha¨kkinen, A. Ha¨kkinen, M. McCormick, J. Volek, and W. J. Kraemer, “Mixed-methods resistance training increases power and strength of young and older men,” Med- icine and Science in Sports and Exercise, vol. 34, no. 8, pp. 1367– 1375, 2002. [65] J. F. Bean, D. K. Kiely, S. Larose, R. Goldstein, W. R. Frontera, and S. G. Leveille, “Are changes in leg power responsible for clinically meaningful improvements in mobility in older adults?” Journal of the American Geriatrics Society, vol. 58, no. 12, pp. 2363–2368, 2010. [66] D. N. Proctor, W. E. Sinning, J. M. Walro, G. C. Sieck, and P. W. R. Lemon, “Oxidative capacity of human muscle ﬁber types: eﬀects of age and training status,” Journal of Applied Physiology, vol. 78, no. 6, pp. 2033–2038, 1995. [67] L. E. Davidson, R. Hudson, K. Kilpatrick et al., “Eﬀects of exercise modality on insulin resistance and functional limita- tion in older adults: a randomized controlled trial,” Archives of Internal Medicine, vol. 169, no. 2, pp. 122–131, 2009. [68] T. M. Manini, A. B. Newman, R. Fielding et al., “Eﬀects of exercise on mobility in obese and nonobese older adults,” Obesity, vol. 18, no. 6, pp. 1168–1175, 2010. [69] T. N. Frimel, D. R. Sinacore, and D. T. Villareal, “Exercise attenuates the weight-loss-induced reduction in muscle mass in frail obese older adults,” Medicine and Science in Sports and Exercise, vol. 40, no. 7, pp. 1213–1219, 2008. [70] P. Chomentowski, J. J. Dube´, F. Amati et al., “Moderate exercise attenuates the loss of skeletal muscle mass that occurs with intentional caloric restriction-induced weight loss in older, overweight to obese adults,” Journals of Gerontology Series A, vol. 64, no. 5, pp. 575–580, 2009. [71] D. T. Villareal, M. Banks, D. R. Sinacore, C. Siener, and S. Klein, “Eﬀect of weight loss and exercise on frailty in obese older adults,” Archives of Internal Medicine, vol. 166, no. 8, pp. 860–866, 2006. [72] S. D. Anton, T. M. Manini, V. A. Milsom et al., “Eﬀects of a weight loss plus exercise program on physical function in overweight, older women: a randomized controlled trial,” Clinical Interventions in Aging, vol. 6, pp. 141–149, 2011.