VEGF receptor heterodimers I Nilsson et al Landegren U (2006) Direct observation of individual endogenous protein complexes in situ by proximity ligation. Nat Methods 3: 995–1000 Suzuki H, Watabe T, Kato M, Miyazawa K, Miyazono K (2005) Roles of vascular endothelial growth factor receptor 3 signaling in differentiation of mouse embryonic stem cell-derived vascular progenitor cells into endothelial cells. Blood 105: 2372–2379 Tammela T, Zarkada G, Wallgard E, Murtomaki A, Suchting S, Wirzenius M, Waltari M, Hellstrom M, Schomber T, Peltonen R, Freitas C, Duarte A, Isoniemi H, Laakkonen P, Christofori G, Yla- Herttuala S, Shibuya M, Pytowski B, Eichmann A, Betsholtz C et al (2008) Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature 454: 656–660 Zhu Z, Hattori K, Zhang H, Jimenez X, Ludwig DL, Dias S, Kussie P, Koo H, Kim HJ, Lu D, Liu M, Tejada R, Friedrich M, Bohlen P, Witte L, Raﬁi S (2003) Inhibition of human leukemia in an animal model with human antibodies directed against vascular endothe- lial growth factor receptor 2. Correlation between antibody afﬁnity and biological activity. Leukemia 17: 604–611 The EMBO Journal is published by Nature Publishing Group on behalf of European Molecular Biology Organization. This article is licensed under a Creative Commons Attribution-Noncommercial- Share Alike 3.0 Licence. [http://creativecommons.org/ licenses/by-nc-sa/3.0/] 1388 The EMBO Journal VOL 29 | NO 8 | 2010 & 2010 European Molecular Biology Organization