Concise report 8. Rostom A, Muir K, Dubé C, et al. Gastrointestinal safety of cyclooxygenase-2 inhibitors: a Cochrane collaboration systematic review. Clin Gastroenterol Hepatol 2007;5:818–28. 9. European Medicines Agency (EMEA). Public statement, London 2005, EMEA/62838/2005. http://www.emea.europa.eu/pdfs/human/press/pr/6275705en. pdf (Accessed: July 2010). 10. US Food and Drug Administration. FDA news release, April 2005. http://www. fda.gov/NewsEvents/Newsroom/PressAnnouncements/2005/ucm108427.htm (Accessed: July 2010). 11. Hunt RH, Lanas A, Stichtenoth DO, et al. Myths and facts in the use of anti- inﬂammatory drugs. Ann Med 2009;41:423–37. 12. Brook RH, Chassin MR, Fink A, et al. A method for the detailed assessment of the appropriateness of medical technologies. Int J Technol Assess Health Care 1986;2:53–63. 13. Fitch K, Bernstein SJ, Aguilar MS, et al. The RAND/UCLA appropriateness method user’s manual. http://www.rand.org/pubs/monograph_reports/MR1269 (Accessed: July 2010). 14. Shekelle P. The appropriateness method. Med Decis Making 2004;24:228–31. 15. Dubois RW, Melmed GY, Henning JM, et al. Guidelines for the appropriate use of non-steroidal anti-inﬂammatory drugs, cyclo-oxygenase-2-speciﬁc inhibitors and proton pump inhibitors in patients requiring chronic anti-inﬂammatory therapy. Aliment Pharmacol Ther 2004;19:197–208. 16. Chan FK, Abraham NS, Scheiman JM, et al. Management of patients on nonsteroidal anti-inﬂammatory drugs: a clinical practice recommendation from the First International Working Party on Gastrointestinal and Cardiovascular Effects of Nonsteroidal Anti-inﬂammatory Drugs and Anti-platelet Agents. Am J Gastroenterol 2008;103:2908–18. APPENDIX 1 European expert panel on the appropriate use of NSAID Gerd R Burmester, Rheumatology, Germany; Francis Berenbaum, Rheumatology, France; Ferdinand Breedveld, Rheumatology, The Netherlands; Maxime Dougados, Rheumatology, France; Emilio Martín Mola, Rheumatology, Spain; Ignazio Olivieri, Rheumatology, Italy; Josef Smolen, Rheumatology, Austria; Stefan Lohmander, Orthopaedics, Sweden; Luigi M Biasucci, Cardiology, Italy; Matthias Hermann, Cardiology, Switzerland; Tom MacDonald, Cardiology and Clinical Pharmacology, UK; Chris Hawkey, Gastroenterology, UK; Angel Lanas, Gastroenterology, Spain; Carmelo Scarpignato, Gastroenterology and Clinical Pharmacology, Italy; Adam Bajkowski, Family Medicine, UK; Peter Dieleman, Family Medicine, Belgium; Tony Mets, Geriatrics, Belgium; Nele Van Den Noortgate, Geriatrics, Belgium. 822 Ann Rheum Dis 2011;70:818–822. doi:10.1136/ard.2010.128660