Figure 1 – T2-weighted sagittal magnetic resonance image showing a hyperintense extradural lesion at the eighth thoracic spinal segment ATRA therapy (45mg/m2/day) combined with daunorubicin (60 mg/m2) on days 2, 4, 6 and 8 was initiated. The patient evolved with ATRA syndrome that was controlled with dexamethasone, and febrile neutropenia, treated with ceftazidime and amikacin. Despite chemotherapy and ATRA, the patient presented deterioration in the weakness of his legs and lost bladder sphincter control. Radiotherapy for the extradural lesion (total dose of 3000 cGy) was attempted but no clear clinical improvement was noticed. Nephrotic syndrome was noted, probably due to treatment with ATRA, which was interrupted. The patient evolved with hematological remission of APL but persistence of the extradural mass. Soon after hematological remission was achieved, he presented with respiratory distress that evolved to hypotension and shock. Pneumonia was diagnosed which was treated with vancomycin and imipenem. Despite intensive care with ventilation support, the patient died of sepsis without any recovery from his neurologic deficit. Discussion APL, described in 1957, is a particular subtype of acute myeloid leukemia (AML). Classically, APL presents as pancytopenia and a hemorrhagic/disseminated intravascular coagulation syndrome. It accounts for 10 to 15% of all AML cases in the United States(1) but it seems to be more frequent in Mexico, Central and South America, Spain and Italy.(2) Once a highly fatal disease during induction therapy, mainly due to bleeding disorders, now it is the most curable AML subtype, mainly due to introduction of ATRA therapy in association with anthracycline-based chemotherapy.(1) More Rev Bras Hematol Hemoter. 2011;33(6):478-80 Acute promyelocytic leukemia presenting as an extradural mass recently, arsenic trioxide has also proved to be useful in APL treatment, especially in relapsed patients.(1) Risk stratification for relapse includes white blood cell and platelet counts at diagnosis, as described by the PETHEMA (Programa para el Estudio de la Terapéutica en Hemopatía Maligna) and GIMEMA(Gruppo Italiano Malattie EMatologiche dell'Adulto) groups. While high risk patients presented a 5-year disease-free survival of 73%, low risk and intermediate risk showed a 5-year disease-free survival of 87% and 90%, respectively.(3) Our patient was classified as intermediate risk. It is important to mention that the early death rate in APL patients has decreased due to use of ATRA soon after diagnosis. This patient died of infection not directly linked to induction therapy but, instead, because of a long immobilization/bed rest, a known risk factor for nosocomial pneumonia, due to his neurological symptoms. Extramedullary infiltration is a very rare complication in patients with APL.(4,5) The majority of cases reported are related to relapse after initial treatment, with the central nervous system and skin being the most frequently involved sites.(6,7) Factors associated with extramedullary relapse include age less than 45 years, high white blood cell count and the bcr3 isoform of PML-RARA.(7) Association of ATRA treatment with extramedullary relapse is controversial.(5,6) Much more uncommon is the description of cases with extramedullary involvement at presentation.(4,8,9) In the literature, there is only one previous report of a extradural spinal mass that was identified one month before the diagnosis of APL.(10) In that particular case, laminectomy was possible as the patient did not present any signs of APL at the time of surgery. The patient was in complete remission after chemotherapy, radiotherapy and autologous bone marrow transplantation (ABMT). However, a MRI 5 months after ABMT suggested a small residual mass. In our case, laminectomy was not possible because the patient had a coagulopathy. Radiotherapy was ineffective to induce significant mass reduction and to alleviate neurologic symptoms. In summary, this patient, who presented with an extradural mass at diagnosis of APL, died of clinical complications of leukemia treatment but also due to failure to ameliorate his neurological symptoms. Laminectomy should be performed as soon as possible as radiotherapy alone seems to be ineffective in some cases. Contributions: Conception and study design was by ALT, EMF and HB. Data collection, analysis, interpretation, and review were byAFLTR, ABFG. The manuscript was written and reviewed by AFLTR, ALT, ABFG, EMF and HB. References 1. Tallman MS, Altman JK. Curative strategies in acute promyelocytic leukemia. Hematology Am Soc Hematol Educ Program. 2008: 391-9. 2. Sanz MA, Grimwade D, Tallman MS, Lowenberg B, Fenaux P, Estey EH, et al. Management of acute promyelocytic leukemia: 479