J Orthopaed Traumatol (2010) 11:195–201 Table 1 Genetic classiﬁcation of hereditary motor and sensory neuropathies Hereditary motor and sensor neuropathy (http://www.ncbi. nlm.nih.gov/omim) Large-caliber ﬁber reduction and formation of isolated monostratiﬁed ‘‘simple onion bulbs’’ have been described in CMT2 [3]. There are no pharmacologic cures for CMT. A well- balanced diet and weight control can help minimize disability. Dietary supplements such as creatine, and HMSN1-CMT1 CMT1A: CMT1B: CMT1C: CMT1D: CMT1E: CMT1F: HMSN2-CMT2 CMT2A1: CMT2A2: CMT2B: CMT2C: CMT2D: CMT2E: CMT2F: CMT2G: CMT2I: CMT2J: CMT2L: AR-CMT2A AR-CMT2E CMT2K: HMSN3—DSN/CHN DSNA DSNB DSNC DSND DSN DSN Congenital hypomyelination CHA CHB CHC HMSN4-CMT4 CMT4A: CMT4B1: CMT4B2: CMT4C: CMT4D: CMT4E: CMT4F: CMT4H: CMT4J HSMN5 Silver syndrome Troyer syndrome Gene PMP-22 P0 protein LITAF EGR2 P0 protein Neuroﬁlament light chain KIF1B MFN2 RAB7 TRPV4 GARS Neuroﬁlament light chain HSPB1 PO PO HSPBE Lam in A/C Med25 GDAP1 PMP-22 MP2 EGRP2 PRX GDAP1 PMO-22 MP2 EGRP2 GDAP1 MTMR2 SBF2 SH3TC2 (KLAA1985) NDRG1 EGR2 Periaxin FGD4 FIG4 Seipin/BSCL2 SPG20 Inheritance Dominant/sporadic Dominant Dominant Dominant Dominant Dominant/sporadic Dominant Dominant Dominant Dominant Dominant Dominant Dominant/recessive Dominant Dominant Dominant Dominant Recessive Recessive Dominant/recessive Dominant/recessive Dominant/recessive Dominant Dominant Recessive Recessive Dominant Dominant Dominant/recessive Recessive Recessive Recessive Recessive Recessive Dominant/recessive Recessive Recessive Recessive Dominant Recessive 197 Locus 17p11 lq22 16pl3 10q21 lq22 8p21 lp36 lp36 3ql3-q22 12q23-q24 7pl5 8p21 7q11-q21 12ql2 lq22 lq22 12q24 lq21.2 19ql3.3 8q21 17p11-2 lq22 10q21/EGR2 Sq23-24 19ql3.1-13.2 8ql3-21.1 17p11.2 lq22 10q21 8q21 11q23 11p15 5q32 8q24 10q21 19ql3 12ql2 6q21 11ql3 13ql2.3 123