Intervention (trial six months or longer) Nicotine replacements therapy Physician intervention Self help Nursing intervention Bupropion Counselling Group therapy (versus self help) Varenecline Cut down to quit with NRT Exercise Rimonabant Notriptyline Clonidine 43,108 22,260 19,504 15,205 9,940 5,028 4,395 2,023 1,833 1,245 1,049 975 776 17 8 7 14 19 12 10 21 7 18 17 21 25 Int. J. Environ. Res. Public Health 2012, 9 203 Table 2. Results of smoking cessation reviews, ordered by number of participants. The order is by numbers of participants in the reviews. Intervention is as described in each review, and details of the reviews is in Table 1. Numbers of patients Percent abstinent with Active Placebo Figure 1. Cessation (quit) rates with placebo in NRT studies according to number in placebo group (size of symbol proportional to number in placebo group, inset scale) (data from Stead et al., 2008 [22]). 10 5 5 11 10 8 6 8 3 14 11 10 14 Relative benefit (95% CI) NNT (95% CI) 1.6 (1.5 to 1.7) 16 (14 to 17) 1.8 (1.6 to 2.0) 30 (25 to 37) 1.3 (1.2 to 1.5) 1.4 (1.3 to 1.5) 2.0 (1.8 to 2.2) 1.5 (1.3 to 1.8) 65 (45 to 110) 38 (27 to 64) 11 (9 to 12) 26 (18 to 46) 1.9 (1.5 to 2.3) 22 (16 to 33) 2.7 (2.1 to 3.4) 7 (6 to 10) 2.0 (1.3 to 3.0) 30 (19 to 74) 1.2 (0.9 to 1.5) 1.5 (1.1 to 2.1) 2.1 (1.5 to 2.9) 1.7 (1.3 to 2.4) 24 (12 to 640) 18 (10 to 72) 9 (6 to 16) 9 (6 to 20)