Structure of the Drosophila Nucleosome Core Particle 9. Boyer LA, Mathur D, Jaenisch R. Molecular control of pluripotency. Curr Opin Genet Dev 2006;16:455–462. 10. Lieberman PM. Chromatin regulation of virus infection. Trends Microbiol 2006;14:132–140. 11. Lund AH, van Lohuizen M. Epigenetics and cancer. Genes Dev 2004;18:2315–2335. 12. Finch JT, Lutter LC, Rhodes D, Brown RS, Rushton B, Levitt M, Klug A. Structure of nucleosome core particles of chromatin. Nature 1977;269:29–36. 13. Bentley GA, Lewit-Bentley A, Finch JT, Podjarny AD, Roth M. Crystal structure of the nucleosome core particle at 16 A resolution. J Mol Biol 1984;176:55–75. 14. Richmond TJ, Finch JT, Rushton B, Rhodes D, Klug A. Structure of the nucleosome core particle at 7 A resolution. Nature 1984;311: 532–537. 15. Arents G, Burlingame RW, Wang B-C, Love WE, Moudrianakis EN. The nucleosomal core histone octamer at 3.1 A˚ resolution: a tripar- tite protein assembly and a left-handed superhelix. Proc Natl Acad Sci USA 1991;88:10148–10152. 16. Luger K, Ma¨der AW, Richmond RK, Sargent DF, Richmond TJ. Crystal structure of the nucleosome core particle at 2.8 A˚ resolu- tion. Nature 1997;389:251–260. 17. Davey CA, Sargent DF, Luger K, Maeder AW, Richmond TJ. Solvent mediated interactions in the structure of the nucleosome core parti- cle at 1.9 A˚ resolution. J Mol Biol 2002;319:1097–1113. 18. Davey CA, Richmond TJ. DNA-dependent divalent cation binding in the nucleosome core particle. Proc Natl Acad Sci USA 2002;99: 11169–11174. 19. Richmond TJ, Davey CA. The structure of DNA in the nucleosome core. Nature 2003;423:145–150. 20. Suto RK, Clarkson MJ, Tremethick DJ, Luger K. Crystal structure of a nucleosome core particle containing the variant histone H2A.Z. Nat Struct Biol 2000;7:1121–1124. 21. Chakravarthy S, Gundimella SK, Caron C, Perche PY, Pehrson JR, Khochbin S, Luger K. Structural characterization of the histone var- iant macroH2A. Mol Cell Biol 2005;25:7616–7624. 22. Harp JM, Hanson BL, Timm DE, Bunick GJ. Asymmetries in the nucleosome core particle at 2.5 A˚ resolution. Acta Crystallogr D Biol Crystallogr 2000;56:1513–1534. 23. White CL, Suto RK, Luger K. Structure of the yeast nucleosome core particle reveals fundamental changes in internucleosome inter- actions. Embo J 2001;20:5207–5218. 24. Tsunaka Y, Kajimura N, Tate S, Morikawa K. Alteration of the nucleosomal DNA path in the crystal structure of a human nucleo- some core particle. Nucleic Acids Res 2005;33:3424–3434. 25. Dyer PN, Edayathumangalam RS, White CL, Bao Y, Chakravarthy S, Muthurajan UM, Luger K. Reconstitution of nucleosome core particles from recombinant histones and DNA. Methods Enzymol 2004;375:23–44. 26. Kabsch W. Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants. J Appl Cryst 1993;26:795–800. 27. The CCP4 suite: programs for protein crystallography. Acta Crystal- logr D Biol Crystallogr 1994;50:760–763. 28. Bru¨nger AT, Adams PD, Clore GM, DeLano WL, Gros P, Grosse- Kunstleve RW, Jiang JS, Kuszewski J, Nilges M, Pannu NS, Read RJ, Rice LM, Simonson T, Warren GL. Crystallography and NMR sys- tem: a new software suite for macromolecular structure determina- tion. Acta Crystallogr D Biol Crystallogr 1998;54:905–921. 29. Jones TA, Zou JY, Cowan SW, Kjeldgaard M. Improved methods for building protein models in electron density maps and the loca- tion of errors in these models. Acta Crystallogr A 1991;47:110–119. 30. Chothia C, Lesk AM. The relation between the divergence of sequence and structure in proteins. Embo J 1986;5:823–826. 31. Hubbard TJ, Blundell TL. Comparison of solvent-inaccessible cores of homologous proteins: definitions useful for protein modelling. Protein Eng 1987;1:159–171. 32. Flores TP, Orengo CA, Moss DS, Thornton JM. Comparison of conformational characteristics in structurally similar protein pairs. Protein Sci 1993;2:1811–1826. 33. Russell RB, Saqi MA, Sayle RA, Bates PA, Sternberg MJ. Recogni- tion of analogous and homologous protein folds: analysis of sequence and structure conservation. J Mol Biol 1997;269:423–439. 34. Sullivan SA, Landsman D. Characterization of sequence variability in nucleosome core histone folds. Proteins 2003;52:454–465. 35. Barbera AJ, Chodaparambil JV, Kelley-Clarke B, Joukov V, Walter JC, Luger K, Kaye KM. The nucleosomal surface as a docking station for Kaposi’s sarcoma herpesvirus LANA. Science 2006;311:856–861. PROTEINS 7