Connective tissue growth factor (CTGF, CCN2) gene regulation promoter activity. J Cell Commun Signal 1:17–32 doi:10.1007/ s12079-007-0003-1 Igarashi A, Okochi H, Bradham DM, Grotendorst GR (1993) Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair. Mol Biol Cell 4:637–645 Ito Y, Aten J, Bende RJ, Oemar BS, Rabelink TJ, Weening JJ, Goldschmeding R (1998) Expression of connective tissue growth factor in human renal fibrosis. Kidney Int 53:853–861 doi:10.1111/j.1523-1755.1998.00820.x Ito Y, Goldschmeding R, Bende R, Claessen N, Chand M, Kleij L, Rabelink T, Weening J, Aten J (2001) Kinetics of connective tissue growth factor expression during experimental proliferative glomerulonephritis. J Am Soc Nephrol 12:472–484 Kantarci A, Black SA, Xydas CE, Murawel P, Uchida Y, Yucekal- Tuncer B, Atilla G, Emingil G, Uzel MI, Lee A, Firatli E, Sheff M, Hasturk H, Van Dyke TE, Trackman PC (2006) Epithelial and connective tissue cell CTGF/CCN2 expression in gingival fibrosis. J Pathol 210:59–66 doi:10.1002/path.2000 Kapoor M, Liu S, Huh K, Parapuram S, Kennedy L, Leask A (2008) Connective tissue growth factor promoter activity in normal and wounded skin. Fibrogenesis Tissue Repair 1:1 doi:10.1186/1755- 1536-1-3 Kennedy L, Parapuram S, Greenspoon J, Leask A. (2008) Ceramide inhibits CCN2 expression in fibroblasts. J Cell Commun Signal. epub. Kidd M, Modlin IM, Shapiro MD, Camp RL, Mane SM, Usinger W, Murren JR (2007) CTGF, intestinal stellate cells and carcinoid fibrogenesis. World J Gastroenterol 13:5208–5216 Koitabashi N, Arai M, Niwano K, Watanabe A, Endoh M, Suguta M, Yokoyama T, Tada H, Toyama T, Adachi H, Naito S, Oshima S, Nishida T, Kubota S, Takigawa M, Kurabayashi M (2008) Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure. Eur J Heart Fail 10:373–379 doi:10.1016/j.ejheart.2008. 02.011 Kondo S, Kubota S, Mukudai Y, Moritani N, Nishida T, Matsushita H, Matsumoto S, Sugahara T, Takigawa M (2006) Hypoxic regulation of stability of connective tissue growth factor/CCN2 mRNA by 3′-untranslated region interacting with a cellular protein in human chondrosarcoma cells. Oncogene 16:1099– 1110 doi:10.1038/sj.onc.1209129 Kubota S, Kondo S, Eguchi T, Hattori T, Nakanishi T, Pomerantz RJ, Takigawa M (2000) Identification of an RNA element that confers post-transcriptional repression of connective tissue growth factor/ hypertrophic chondrocyte specific 24 (ctgf/ hcs24)gene: similarities to retroviral RNA-protein interactions. Oncogene 19:4773–4786 doi:10.1038/sj.onc.1203835 Kuiper EJ, Van Nieuwenhoven FA, de Smet MD, van Meurs JC, Tanck MW, Oliver N, Klaassen I, Van Noorden CJ, Goldschmeding R, Schlingemann RO (2008) The angio-fibrotic switch of VEGF and CTGF in proliferative diabetic retinopathy. PLoS One 3(7):e2675 doi:10.1371/journal.pone.0002675 Leask A (2008) The Starbuck stops here: it’s a Smad world. J Cell Commun Signal. epub Leask A, Abraham DJ (2006) All in the CCN family: essential matricellular signaling modulators emerge from the bunker. J Cell Sci 119:4803–4810 doi:10.1242/jcs.03270 Leask A, Sa S, Holmes A, Shiwen X, Black CM, Abraham DJ (2001) The control of ccn2 (ctgf) gene expression in normal and scleroderma fibroblasts. Mol Pathol 54:180–183 doi:10.1136/mp.54.3.180 Leask A, Holmes A, Black CM, Abraham DJ (2003) Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts. J Biol Chem 278:13008–13015 doi:10.1074/jbc.M210366200 Leask A, Denton CP, Abraham DJ (2004) Insights into the molecular mechanism of chronic fibrosis: the role of connective tissue 93 growth factor in scleroderma. J Invest Dermatol 122:1–6 doi:10.1046/j.0022-202X.2003.22133.x Leask, A., Chen, S., Pala D, Brigstock, DR. (2008) Regulation of CCN2 mRNA expression and promoter activity in activated hepatic stellate cells. J Cell Commun Signal, epub Luo Q, Kang Q, Si W, Jiang W, Park JK, Peng Y, Li X, Luu HH, Luo J, Montag AG, Haydon RC, He TC (2004) Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphoge- netic proteins signaling in osteoblast differentiation of mesen- chymal stem cells. J Biol Chem 279:55958–55968 doi:10.1074/ jbc.M407810200 Nguyen TQ, Tarnow L, Andersen S, Hovind P, Parving HH, Goldschmeding R, vanNieuwenhoven FA (2006) Urinary con- nective tissue growth factor excretion correlates with clinical markers of renal disease in a large population of type 1 diabetic patients with diabetic nephropathy. Diabetes Care 29:83–88 doi:10.2337/diacare.29.01.06.dc05-1670 Paradis V, Dargere D, Vidaud M, De Gouville AC, Huet S, Martinez V, Gauthier JM, Ba N, Sobesky R, Ratziu V, Bedossa P (1999) Expression of connective tissue growth factor in experimental rat and human liver fibrosis. Hepatology 30:968–976 doi:10.1002/ hep.510300425 Phanish MK, Wahab NA, Hendry BM, Dockrell ME (2005) TGF- beta1-induced connective tissue growth factor (CCN2) expres- sion in human renal proximal tubule epithelial cells requires Ras/ MEK/ERK and Smad signalling. Nephron, Exp Nephrol 100: e156–e165 doi:10.1159/000085445 Pickles M, Leask A (2007) Analysis of CCN2 promoter activity in PANC-1 cells: regulation by ras/MEK/ERK. J Cell Commun Signal 1(2):85–90 doi:10.1007/s12079-007-0008-9 Qi W, Chen X, Twigg S, Zhang Y, Gilbert RE, Kelly DJ, Pollock CA (2007) The differential regulation of Smad7 in kidney tubule cells by connective tissue growth factor and transforming growth factor-beta1. Nephrology 12:267–274 doi:10.1111/j.1440- 1797.2007.00788.x Ricupero DA, Rishikof DC, Kuang PP, Poliks CF, Goldstein RH (1999) Regulation of connective tissue growth factor expression by prostaglandin E(2). Am J Physiol 277:L1165–L1171 Riser BL, Cortes P, DeNichilo M, Deshmukh PV, Chahal PS, Mohammed AK, Yee J, Kahkonen D (2003) Urinary CCN2 (CTGF) as a possible predictor of diabetic nephropathy: preliminary report. Kidney Int 264:451–458 doi:10.1046/j.1523- 1755.2003.00130.x Sato S, Nagaoka T, Hasegawa M, Tamatani T, Nakanishi T, Takigawa M, Takehara K (2000) Serum levels of connective tissue growth factor are elevated in patients withsystemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis. J Rheumatol 7:149–154 Shi-wen X, Howat SL, Renzoni EA, Holmes A, Pearson JD, Dashwood MR, Bou-Gharios G, Denton CP, du Bois RM, Black CM, Leask A, Abraham DJ (2004) Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK. J Biol Chem 279:23098–23103 doi:10.1074/jbc. M311430200 Shi-wen X, Stanton L, Kennedy L, Pala D, Chen Y, Howat SL, Renzoni EA, Carter DE, Bou-Gharios G, Stratton RJ, Pearson JD, Beier F, Lyons KM, Black CM, Abraham DJ, Leask A (2006) CCN2 is necessary for adhesive responses to TGFß1 in embryonic fibroblasts. J Biol Chem 281:10715–10726 doi:10.1074/jbc.M511343200 Shi-Wen X, Renzoni EA, Kennedy L, Howat S, Chen Y, Pearson JD, Bou-Gharios G, Dashwood MR, du Bois RM, Black CM, Denton CP, Abraham DJ, Leask A (2007a) Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpres- sion in fibrotic fibroblasts. Matrix Biol 26:625–632 doi:10.1016/ j.matbio.2007.06.003