Argano et al Cases TABLE I - EFFECTS OF TREATMENTS ON BLOOD PRESSURE AND CLINICAL MEASUREMENTS Losartan 19 Ramipril 19 Combined 19 Baseline Treatment Baseline Treatment Baseline Treatment Sex (F/M) 10/9 Age (years) 56 ± 7 BMI (kg/m2) 31.6 ± 4.9 SBP (mmHg) 162 ± 70 DBP (mmHg) 94 ± 6 MBP(mmHg) 116 ± 80 BUN (mg/dL) 42 ± 9 Creatinine (mg/dL) 1.01 ± 0.2 Creatinine clearance (mL/min) 089 ± 14 Potassium (mEq/L) 04.5 ± 0.3 10/9 56 ± 7 31.2 ± 4.8 133± 5* .82 ± 7* 100 ± 6*. 42 ± 8 1.03 ± 0.2 ..87 ± 17 04.6 ± 0.6 10/9 54 ± 8 29.7 ± 4.3 159 ± 70 98 ± 9 118 ± 90 37 ± 9 0.99 ± 0.1 93 ± 9 04.6 ± 0.4 10/9 54 ± 8 29.3 ± 4.1 134 ± 5*. .81 ± 8* 100 ± 8*. 38 ± 6 0.99 ± 0.2 094 ± 15 04.8 ± 0.5 10/9 57 ± 7 30 ± 5 161 ± 80 094 ± 12 116 ± 90 42 ± 7 1.02 ± 0.2 090 ± 13 04.6 ± 0.2 10/9 57 ± 7 29.5 ± 4.5 131 ± 6*. .78 ± 8* 095 ± 7* 43 ± 6 1.03 ± 0.2 089 ± 15 04.9 ± 0.6 BMI: Body Mass Index. SBP: Systolic blood pressure. DBP: Diastolic blood pressure. MBP: Mean blood pressure. BUN: Blood Urea Ni- trogen. *p< 0.05 vs baseline Fig. 1 - Trial profile. tions for improving the quality of report or randomised trial (22). We studied three groups of subjects each of them matched for age, BMI, and blood pressure values. Then, groups were randomly allocated into one of the three therapy arms. The first arm was treated with losar- tan 50 mg/day, the second arm was treated with ramipril 5 mg/day, and the third was treated with a combination of the two drugs (losartan 50 mg plus ramipril 5 mg). (Fig. 1). Blood pressure normalization (SBP 140 mmHg and DBP 90 mmHg) occured in all hypertensives. To achieve this goal only a few patients in each treatment group also received hydrochlorotiazyde (12.5 mg once daily) (losartan group n= 1 patient; ramipril group n= 1 patient; combined group n= 1 patient). The follow-up was 24 weeks. Each patient entered into the study was uniquely identified for study purposes by a four-digit patient number, and each group was labelled by a letter corre- sponding to drug regimen that was concealed until sta- tistical analysis was complete. The drug regimen was 41