Cheon et al. clinical presentation, three groups of hepatic dysfunction, and type of MR finding using non-parametric probability tests (Mann-Whitney or Kruskal-Wallis). All p-values were based on two tailed comparisons and a 5% confidence- level was considered to indicate a statistically significant difference. Statistical analyses were performed with SPSS 7.5 for Windows (SPSS, Chicago, IL). RESULTS Clinical Features At the time of diagnosis, 12 patients presented with neurological dysfunction, compared to 38 patients who presented with non-neurological manifestations (33 patients with hepatic dysfunction and five asymptomatic siblings of index cases). The K-F ring was most common in the neurological presentation (92%, 11 of 12) relative to non-neurological presentation (45%; 17 of 38; p = 0.006). There were no statistically significant differences between sex, age, presence of medical treatment, and duration of treatment among both clinical presentations (Table 1). Patient hepatic function was categorized as Child-Pugh class A in 36 patients, Child-Pugh class B in five patients, and Child-Pugh class C in nine patients. Mean age at diagnosis was 11.1 years in class A, 13.4 years in class B, and 17.0 years in class C. A statistically significant differ- Table 2. Association Between Liver MR Imaging and Hepatic Dysfunction Liver MR Findings Intrahepatic nodule Hypointense nodules on T2WI Grade 1 Grade 2 Hyperintense nodules on T1WI Hepatic Contour Surface nodularity Caudate hypertrophy Gallbladder fossa widening Others Ascites Venous collaterals Gallbladder wall edema Splenomegaly No. of Patients 25 (50%) 13 (26%) 12 (24%) 14 (28%) 25 (50%) 10 (20%) 29 (58%) 7 (14%) 10 (20%) 12 (24%) 40 (80%) A (n = 36) 12 (33%) 9 (25%) 3 (8%) 6 (17%) 13 (36%) 2 (6%) 17 (47%) 1 (3%) 3 (8%) 2 (6%) 27 (75%) Child-Pugh Classification B (n = 5) 5 (100%) 2 (40%) 3 (60%) 4 (80%) 4 (80%) 3 (60%) 5 (100%) 1 (20%) 1 (20%) 3 (60%) 4 (80%) C (n = 9) 8 (89%) 2 (22%) 6 (67%) 4 (44%) 8 (89%) 5 (56%) 7 (78%) 5 (56%) 6 (67%) 7 (78%) 9 (100%) P value < 0.001 0.004 0.006 < 0.001 0.031 0.001 0.012 < 0.001 0.243 Note.─ Grade 1 = granular nodules (≤ 3 mm in diameter), Grade 2 = macronodular lesions (> 3 mm in diameter), SI = signal intensity, T1WI = T1- weighted images, T2WI = T2-weighted images A B Fig. 3. 11-year-old boy with Wilson’s disease (Child-Pugh class B) A. T2-weighted image shows mild irregularity of liver surface and multiple, hypointense nodules in liver. B. These macronodular lesions show hyperintensities on T1-weighted images. 668 Korean J Radiol 11(6), Nov/Dec 2010