Int. J. Environ. Res. Public Health 2012, 9 3. Cocaine cessation reviews Minozzi et al. 2008 [27] Anticonvulsants and placebo Lima Reisser et al. 2002 [28] Carbamazepine and placebo Silva de Lima et al. 2003 [29] Antidepressants and placebo Soares et al. 2003 [30] Amato et al. 2007 [31] results for desipramine Dopamine agonists and placebo results for amantadine Antipsychotics and placebo Reference Interventions Study characteristics Duration Outcome Randomised trials and controlled trials Cocaine dependent patients (DSM classification) Adults Randomised trials Cocaine dependent patients (DSM classification) Adults Randomised trials and controlled trials Cocaine dependent patients (DSM classification) Adults Randomised trials Cocaine dependent patients (DSM classification) Adults Randomised trials and controlled trials Cocaine dependent patients (DSM classification) Adults Table 1. Cont. Mean duration 11 weeks (range 1–24 weeks) 1–6 months 1–6 months Non-use of cocaine (self report or measurement) Maintained in the programme—did not drop out Non-use of cocaine (measurement) Maintained in the programme—did not drop out Intervention 126/270 (47%) Abstinence with Placebo 102/198 (52%) 60/152 (39.5%) 51/161 (31.7%) 59/136 (43.3%) 65/130 (50%) 34/88 (38.6%) 34/127 (26.8%) 2–16 weeks+, but mainly 12–16 weeks Non-use of cocaine (measurement) 6–24 weeks 62/106 (58%) 46/102 (45%) Comments RR 1.1 (0.9 to 1.3) 200