Thyroid disturbance related to hepatitis C therapy Danilovic DLS et al. CLINICS 2011;66(10):1757-1763 Figure 1 - Hormonal, thyroglobulin, and aminotransferases changes during the 12-month follow-up of 14 HCV-infected patients with normal thyroid function during IFNa and ribavirin treatment. Differences were assessed using Kruskal-Wallis tests. * p = 0.039 compared to the initial levels. # p = 0.008 compared to the initial levels. Reference values: TT3, 40 to 180 ng/dL; TT4, 4.5 to 12 mg/dL; FT4, 0.7 to 1.5 ng/dL; TSH, 0.4 to 4.5 mUI/L; Tg,55 ng/dL (by fluoroimmunoassay); AST,37 or ,31 UI/L and ALT,41 or ,31 UI/L for males or females, respectively. decreases in TT3 and TSH levels along with an increase in reverse T3 levels without any change in TT4 or FT4 levels. They attributed the hormonal changes to increases in IL-6 levels and interferon-induced cortisol release. Finally, the decrease in TT3 and TT4 levels during treatment may be related to the improvement of the hepatocellular lesions, as indicated by the reduction in ALT levels. Unfortunately, we did not evaluate thyroxine-binding globulin (TBG) to confirm 1760