Table 2 | The primary analysis of changes in HRQOL, the area under the curve results, for each scale determined over 18 months Group A (high target arm) Group B (low target arm) n 424 423 424 426 422 416 427 Mean±s.d. 45.1±19.6 36.2±24.5 69.3±19.6 57.0±24.5 34.6±34.8 57.2±38.1 65.5±24.2 n 427 426 426 428 429 419 428 Abbreviation: HRQOL, health-related quality of life. Death and missing values were assigned a last value carried forward. There are no significant differences in scores between groups in any scale. From ACTR pages 70 and 148. Table 3 | The mean scale scores for primary end points (vitality, physical function, and mental health) and secondary end points over time Group A (high target arm) Group B (low target arm) Mean±s.d. 43.6±19.8 36.0±25.0 69.8±18.9 57.4±24.5 35.3±34.7 60.1±37.1 66.6±23.8 Mean±s.d. 44.7±21.8 44.3±22.3 43.0±22.2 42.0±21.8 38.6±27.5 36.8±27.7 35.0±27.5 35.9±26.9 69.9±20.6 70.3±20.9 69.5±21.3 68.8±21.3 58.7±28.2 58.7±27.6 56.7±27.9 55.4±27.7 33.3±38.5 36.0±41.4 34.9±40.5 35.7±40.3 59.7±43.5 60.1±43.6 59.1±44.6 61.6±43.6 66.4±27.5 67.7±28.0 65.9±27.9 65.5±27.8 P-value 0.25 0.88 0.72 0.83 0.78 0.25 0.49 P-value 0.90 0.26 0.23 0.13 0.99 0.95 0.97 0.56 0.78 0.40 0.73 0.98 0.85 0.57 0.79 0.74 0.95 0.87 0.72 0.38 0.28 0.43 0.44 0.14 0.48 0.23 0.74 0.76 o r i g i n a l a r t i c l e HRQOL scale Primary end points Vitality Physical function Mental health Secondary end points Body pain Physical role Emotional role limitations Social function HRQOL scale Vitality Baseline 6 months 12 months 18 months Physical function Baseline 6 months 12 months 18 months Mental health Baseline 6 months 12 months 18 months Body pain Baseline 6 months 12 months 18 months Physical role limitations Baseline 6 months 12 months 18 months Emotional role limitations Baseline 6 months 12 months 18 months Social function Baseline 6 months 12 months 18 months 238 n 425 425 425 424 424 424 424 423 425 425 425 424 427 427 427 426 423 423 423 422 417 417 417 416 428 428 428 427 DW Coyne: Quality of life in the Normal Hematocrit Trial Mean±s.d. 44.5±22.0 46.0±22.3 44.8±21.9 44.3±21.8 38.6±26.7 37.0±26.7 35.0±27.3 34.9±26.5 70.3±20.7 69.1±21.2 69.0±21.9 68.8±21.4 58.3±27.4 57.6±27.5 56.2±27.9 56.0±28.2 33.1±38.9 36.5±41.0 33.9±41.0 33.2±41.1 56.4±44.3 57.7±44.6 56.8±44.4 57.0±44.8 65.0±27.8 65.5±27.2 65.3±28.2 66.1±27.7 n 429 429 429 427 428 428 428 426 428 428 428 426 430 430 430 428 431 431 431 429 421 421 421 419 430 430 430 428 Abbreviation: HRQOL, health-related quality of life. There are no significant differences in scores between groups at any time, and scores did not change significantly over time. Death and missing values were assigned a last value carried forward. From ACTR pages 70, 149, and 150. Kidney International (2012) 82, 235–241