Journal of the American Chemical Society ’ ACKNOWLEDGMENT This work was supported partially by (1) George Mason University, (2) the Italian Istituto Superiore di Sanita’ in the framework of the Italy/USA cooperation agreement between the U.S. Department of Health and Human Services, George Mason University, and the Italian Ministry of Public Health, (3) NIH, NCI Grant 1R21CA137706-01 to L.A.L., (4) Grant 1R21AR061075-01 to L.A.L. from NIAMS/NIH. The funding organizations did not have any role in data collection and analysis, decision to publish, or preparation of the manuscript. We are grateful to David Houston for knowledgeable insights about dye chemistries and to Dr. Francesco Facchiano for fruitful discussions on mass spectrometry-based proteomics. ’ REFERENCES (1) Aebersold, R.; Mann, M. Nature 2003, 422, 198. (2) Poste, G. Nature 2011, 469, 156. (3) Gerszten, R. E.; Accurso, F.; Bernard, G. R.; Caprioli, R. M.; Klee, E. W.; Klee, G. G.; Kullo, I.; Laguna, T. A.; Roth, F. 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