The analysis of prognostic factors affecting post-radiation acute reaction after conformal radiotherapy for non-small cell lung cancer most often in patients who received low doses in a large volume of lung tissue. R e f e r e n c e s 1. Kepka L, Bujko K, Zolciak-Siwinska A. Risk of isolated nodal failure for non-small cell lung cancer (NCSLC) treated with the elective nodal irradiation (ENI) using (3D-CRT) techniques – a retrospective analysis. Acta Oncol 2008; 47: 95-103. 2. Sanuki-Fujimoto N, Sumi M, Ito Y, et al. Relation between elective nodal failure and irradiation volume in non-small cell lung cancer (NCSLC) treated with radiotherapy using conventional fields and doses. Radiother Oncol 2009; 91: 433-7. 3. Perez CA, Bauer M, Edelstein S, Gillespie BW, Birch R. Impact of tumor control on survival in carcinoma of the lung treated with irradiation. Int J Oncol Radiat Biol Phys 1986; 12: 539-47. 4. Hazuka MB, Turissi AT 3rd, Lutz ST, et al. Results of high dose thoracic irradiation incorporating beam’s eye view display in non small cell lung cancer: a retrospective multivariete analysis. Int J Radiat Oncol Biol Phys 1993; 27: 273-84. 5. Hayman JA, Martel MK, Ten Haken RK, et al. Dose escalation in non small cell lung cancer using three dimensional conformal radiation therapy: update of a phase I trial. J Clin Oncol 2001; 19: 127-36. 6. Inoue A, Kunitoh H, Sekine I, Sumi M, Tokuuye K, Saijo N. Radiation pneumonitis in lung cancer patients: a retrospective study of risk factors and the long term prognosis. Int J Radiat Oncol Biol Phys 2001; 49: 649-55. 7. Yorke ED, Jackson A, Rosenzweig KE, Braban L, Leibel S, Ling C. Correlation of dosimetric factors and radiation pneumonitis for non small cell lung cancer patients in a recently completed dose escalation study. Int J Radiat Oncol Biol Phys 2005; 63: 672-82. 8. Schallenkamp JM, Miller RC, Brinkmann DH, Foote T, Garces Y. Incidance of radiation pneumonitis after thoracic irradiation: dose volume correlates. Int J Radiat Oncol Biol Phys 2007; 67: 410-6. 9. Kong FM, Hayman JA, Griffith KA, et al. Final toxicity results of radiation-dose escalation study in patients with non small cell lung cancer (NSCLC): Predictors of radiation pneumonitis and fibrosis. Int J Radiat Oncol Biol Phys 2006; 65: 1075-86. 10. Graham MV, Purdy JA, Emami B, et al. Clinical dose-volume histogram analysis for pneumonitis after 3D treatment for non small cell lung cancer (NSCLC). Int J Radiat Oncol Biol Phys 1999; 45: 323-9. 11. Sunyach MP, Falchero L, Pommier P, et al Prospective evaluation of early lung toxicity following three – dimensional conformal radiation therapy in non small cell lung cancer. Preliminary results. Int J Radiat Oncol Biol Phys 2000; 48: 459-63. 12. Wang S, Liao Z, Wei X, et al. Analysis of clinical and dosimetric factors associated with treatment – related pneumonitis (TRP) in patients with non small cell lung cancer (NSCLC) treated with concurrent chemotherapy and three dimensional conformal radiotherapy (3D-CRT). Int J Radiat Oncol Biol Phys 2006; 66: 1399-1407. 13. Fay M, Tan A, Fisher R, Mac Manus M, Wirth A, Ball D. Dose-volume histogram analysis as predictor of radiation pneumonitis in primary lung cancer patients treated with radiotherapy. Int J Radiat Oncol Biol Phys 2005; 61: 1355-63. 14. Wang JY, Chen KY, Wang JT, et al. Outcome and prognostic factors for patients with non small cell lung cancer and severe radiation pneumonitis. Int J Radiat Oncol Biol Phys 2002; 54: 735-41. 15. Yorke ED, Jackson A, Rosenzweig KE, et al. Dose – volume factors contributing to the incidence of radiation pneumonitis in non small cell lung cancer patients treated with three-dimensional conformal radiation therapy. Int J Radiat Oncol Biol Phys 2002; 54: 329-39. 16. Claude L, Perol D, Ginestet Ch, et al. A prospective study on radiation pneumonitis following conformal radiation therapy in non small cell lung cancer: clinical and dosimetric factors analysis. Radiother Oncol 2004; 71: 175-81. 17. Rancati T, Ceresoli GL, Gagliardi G, Schipani S, Cattaneo GM. Factors predicitng radiation pneumonitis in lung cancer patients: a retrospective study. Radiother Oncol 2003; 67: 275-83. 18. Willner J, Jost A, Baier K, Flentje M. A little to a lot or a lot to a little? Strahlenther Onkol 2003; 179: 548-56. 19. Hernando ML, Marks LB, Bentel GC, et al. Radiation – induces pulmonary toxicity: a dose – volume histogram analysis in 201 patients with lung cancer. Int J Radiat Oncol Biol Phys 2001; 51: 650-9. 20. Hope AJ, Lindsay PE, Naqa IE, et al. Modeling radiation pneumonitis risk with clinical, dosimetric, and spatial parameters. Int J Radiat Oncol Biol Phys 2006; 65: 112-14. 21. Schild SE, Stella PJ, Geyer SM, et al. The outcome of combined modality therapy for stage III non small cell cancer in the elderly. J Clin Oncol 2003; 21: 3201-6. 22. Robnett TJ, Machtay M, Vines EF, McKenna MG, Algazyk KM, McKena WG. Factors predicting severe radiation pneumonitis in patients receiving definitive chemoradiation for lung cancer. Int J Radiat Oncol Biol Phys 2000; 48: 89-94. 23. Robert F, Childs HA, Spencer SA, Redden DT, Hawkins MM. Phase I/II study of concurrent paclitaxel and cisplatin with radiation therapy in locally advanced non small cell lung cancer. Analysis of early and late pulmonary morbidity. Semin Radiat Oncol 1999; 9: 136-47. 24. Langendijk H, Jong J, Wanders R, Lambin P, Slotman B. The importance of pre-treatment haemoglobine level in inoperable non small cell lung carcinoma with radical radiotherapy. Radiother Oncol 2003; 67: 321-5. 25. Panakis N, McNair HA, Christian JA, et al. Defining the margins in the radical radiotherapy of non-small cell lung cancer (NSCLC) with active breathing control (ABC) and the effect on physical lung parameters. Radiother Oncol 2008; 87: 65-72. 26. Cattaneo GM, Dell’oca I, Broggi S, et al. Treatment planning comparison between conformal radiotherapy and helical tomotherapy in the case of locally advanced- stage NSCLC. Radiother Oncol 2008; 88: 310-8. Arch Med Sci 5, October / 2010 763