Scientific Comments activator and this may result in thrombotic tendency. It would have been interesting to look at PAI-1 levels as well and this aspect needs to be considered in future studies. While this paper reaffirms the association of elevated fibrinogen with coronary artery disease, in view of the multifaceted nature of atherosclerosis, especially the emerging role of inflammation in its pathogenesis, information on inflammatory markers would have been valuable(9,10). Further follow-up on the three cohorts with serial measurements of different parameters would give additional insight into correlating the progression of the disease with different haemostatic and fibrinolytic parameters. References 1. Furie B, Furie BC. Mechanisms of thrombus formation. N Eng J Med. 2008;359(9):938-49. 2. Lima LM, Carvalho MG, Sousa MO. Plasminogen and fibrinogen plasma levels in coronary artery disease. Rev Bras Hematol Hemoter. 2012;34(4):262-3. 3. Meade TW, Mellows S, Brozovic M, Miller GJ, Chakrabarti RR, North WR, et al. Hemostatic function and ischemic heart disease: principal xxx results of the Northwick Park Heart Study. Lancet. 1986;6(8506):533–7. Comment in: Lancet. 1991;338(8774):1079. 4. Kannel WB, Wolf PA, Castelli WP, D’Agostino RB. Fibrinogen and risk for cardiovascular disease. JAMA. 1987;258(9):1183–6. 5. Bini A, Fenoglio JJ Jr., Mesa-Tejada R, Kudryk B, Kaplan KL. Identification and distribution of fibrinogen, fibrin, and fibrin(ogen) degradation products in atherosclerosis. Use of monoclonal antibodies. Arteriosclerosis. 1989;9(1):109-21. 6. Haverkate F, Samama M. Familial dysfibrinogenemia and thrombophilia. Report on a study of the SSC Subcommittee on Fibrinogen. Thromb Haemost. 1995;73(1):151-61. 7. Dolan G. Preston FE. Familial plasminogen thromboembolism. Fibrinolysis. 1988;2(Supp 2):26-34. deficiency and 8. Hoekstra T, Geleijnse JM, Schouten EG, Kluft C. Plasminogen activator inhibitor-type 1: its plasma determinants and relation with cardiovascular risk. Thromb Haemost. 2004;91(5): 861-72. 9. Paoletti R, Gotto AM Jr., Hajjar DP. Inflammation in atherosclerosis and implications for therapy. Circulation. 2004;109(23 Suppl 1):III20-26. 10. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352(16):1685-95. Comment in: N Engl J Med. 2005;353(4):429-30; author reply 429-30. Rev Bras Hematol Hemoter. 2012;34(4):254-64 263