Kirk J. Mantione contributing factor in neuroimmune/vascular endothelial-coupled cellular pathologies [1, 20-34]. The nervous system serves an existential integrative capacity for functional entrainment of multiple organ function. Within the central and peripheral nervous systems, sensory, motor, and intrinsic neurons employ a wide variety of chemical and gaseous messenger molecules. Accordingly, central and peripheral neurons integrate sensory input and coordinated motor responses via immediate and long lasting chemical messengers. As stated above, vital neuroimmune/vascular endothelial-coupled metabolic regulation modu- lates homeostasis of cellular energy production in multiple organ systems. Its dysregulation is intimately associated with a variety of acute and chronic pathophysiological disorders [35-55]. Multiple organ pathologies are intimately associated with acute and chronic dysregulation of metabolic processes responsible for normal neuroimmune/vascular endothelial coupling events. An in depth analysis of perturbation of common regulatory events underlying normal mitochondrial function will elucidate convergent mechanisms leading to the initiation and persistence of multiple organ pathologies in human metabolic disorders. R e f e r e n c e s 1. Stefano GB, Esch T, Bilfinger TV, Kream RM. Proinflammation and preconditioning protection are part of a common nitric oxide mediated process. Med Sci Monit 2010; 16: RA125-30. 2. Kream RM, Stefano GB. Endogenous morphine and nitric oxide coupled regulation of mitochondrial processes. Med Sci Monit 2009; 15: RA263-8. 3. Bismuth J, Chai H, Lin PH, Yao Q, Chen C. Lactosylceramide causes endothelial dysfunction in porcine coronary arteries and human coronary artery endothelial cells. Med Sci Monit 2009; 15: BR270-4. 4. Hamzaoui K, Bouali E, Ghorbel I, Khanfir M, Houman H, Hamzaoui A. Expression of Th-17 and RORgammat mRNA in Behcet’s Disease. Med Sci Monit 2011; 17: CR227-34. 5. Li W, Yang SY, Hu ZF, Winslet MC, Wang W, Seifalian AM. Growth factors enhance endothelial progenitor cell proliferation under high-glucose conditions. Med Sci Monit 2009; 15: BR357-63. 6. Misra MK, Sarwat M, Bhakuni P, Tuteja R, Tuteja N. Oxidative stress and ischemic myocardial syndromes. Med Sci Monit 2009; 15: RA209-19. 7. Suminska-Jasinska K, Polubinska A, Ciszewicz M, Mikstacki A, Antoniewicz A, Breborowicz A. Sulodexide reduces senescence-related changes in human endothelial cells. Med Sci Monit 2011; 17: CR222-6. 8. Voisard R, Munder U, von ML, Baur R, Hombach V. Direct inhibitory effects of Ganciclovir on ICAM-1 expression and proliferation in human coronary vascular cells (SI/MPL-ratio: >1). Med Sci Monit 2011; 17: I1-6. 9. Voisard R, Ramiz E, Baur R, et al. Pulsed perfusion in a venous human organ culture model with a Windkessel function (pulsed perfusion venous HOC-model). Med Sci Monit 2010; 16: CR523-9. 10. Xiao-Yun X, Zhuo-Xiong C, Min-Xiang L, et al. Ceramide mediates inhibition of the AKT/eNOS signaling pathway by palmitate in human vascular endothelial cells. Med Sci Monit 2009; 15: BR254-61. 11. Xiao-Yun X, Zhao-Hui M, Ke C, Hong-Hui H, Yan-Hong X. Glucagon-like peptide-1 improves proliferation and differentiation of endothelial progenitor cells via upregulating VEGF generation. Med Sci Monit 2011; 17: BR35-41. 12. Yang H, Zhang L, Weakley SM, Lin PH, Yao Q, Chen C. Transforming growth factor-beta increases the expression of vascular smooth muscle cell markers in human multi- lineage progenitor cells. Med Sci Monit 2011; 17: BR55-61. 13. Zhang D, Wang W, Zhou D, et al. Ghrelin inhibits apoptosis induced by palmitate in rat aortic endothelial cells. Med Sci Monit 2010; 16: BR396-403. 14. Bissinger A, Grycewicz T, Grabowicz W, Lubinski A. Endothelial function and left ventricular remodeling in diabetic and non-diabetic patients after acute coronary syndrome. Med Sci Monit 2011; 17: CR73-7. 15. Cable DG, Celotto AC, Evora PR, Schaff HV. Asymmetric dimethylarginine endogenous inhibition of nitric oxide synthase causes differential vasculature effects. Med Sci Monit 2009; 15: BR248-53. 16. Chrusciel P, Goch A, Banach M, Mikhailidis DP, Rysz J, Goch JH. Circadian changes in the hemostatic system in healthy men and patients with cardiovascular diseases. Med Sci Monit 2009; 15: RA203-8. 17. Krejca M, Plewka A, Szmagala P, et al. Outside stenting of the vein graft decreases VEGF-A expression and induces significant down-regulation of VEGFR-1 in the intimal and medial layers after the re-endothelialization period. Med Sci Monit 2010; 16: BR89-96. 18. Li Y, Wu Y, Wang Z, Zhang XH, Wu WK. Fasudil attenuates lipopolysaccharide-induced acute lung injury in mice through the Rho/Rho kinase pathway. Med Sci Monit 2010; 16: BR112-8. 19. Michalska M, Gluba A, Mikhailidis DP, et al. The role of polyphenols in cardiovascular disease. Med Sci Monit 2010; 16: RA110-9. 20. Chalubinski M, Broncel M. Influence of statins on effector and regulatory immune mechanisms and their potential clinical relevance in treating autoimmune disorders. Med Sci Monit 2010; 16: RA245-51. 21. Fang Y, Hu J. Toll-like receptor and its roles in myocardial ischemic/reperfusion injury. Med Sci Monit 2011; 17: RA100-9. 22. Kiykim AA, Genctoy G, Horoz M, et al. Nephrotic-range proteinuria with small glomerular fibrillary deposits in a patient on diphenylhydantoin treatment. Med Sci Monit 2009; 15: CS132-4. 23. Lorenson L, DeSantis A, Mannath T, Mirza F, Weeks BS. The antimicrobial and phagocytic defense mechanisms of the terrestrial gastropod Lehmannia nyctelia against Escherichia coli and Staphylococcus aureus. Med Sci Monit 2010; 16: BR339-46. 24. Mravec B, Ondicova K, Valaskova Z, Gidron Y, Hulin I. Neurobiological principles in the etiopathogenesis of disease: when diseases have a head. Med Sci Monit 2009; 15: RA6-16. 25. Rigante D. Autoinflammatory syndromes behind the scenes of recurrent fevers in children. Med Sci Monit 2009; 15: RA179-87. 26. Selim AA. Osteoactivin bioinformatic analysis: prediction of novel functions, structural features, and modes of action. Med Sci Monit 2009; 15: MT19-33. 742 Arch Med Sci 5, October / 2011