Tolouei et al.: Leishmanicidal Activity of Films Containing Paromomycin… Grögl M. WR279,396, a third genera- tion aminoglycoside ointment for the treatment of Leishmania major cutaneous leishmaniasis: a phase 2, randomized, double blind, placebo controlled study. PLoS Neg Trop Dis. 2009;3(5):e432. Epub 2009 May 5. 10. Khamesipour A, Rafati S, Davoudi N, Mahboudi F and Modabber F. Leishmaniasis vaccine candidates for development: Global Overview, In- dian J Med Res 123, March 2006, pp 423-438. 11. Noazin S, Modabber F, Khamesipour A, Smith PG, Moulton LH, Nasseri K, Sharifi I, Khalil EA, Bernal ID, Antunes CM, Kieny MP, Tanner M. First generation leishmaniasis vac- cines: a review of field efficacy tri- als.vaccine.2008 9;26(52):6759-67. Epub 2008 Oct 23. 12. Desjeux P. Leishmaniasis. Public health aspects and control. Clin Der- matol. 1996; 14(5):417-23.Noazin S, Khamesipour A, Moulton LH, Tanner M, Nasseri K, Modabber F, Sharifi I, Khalil EA, Bernal ID, Antunes CM, Smith PG. Efficacy of killed whole- parasite vaccines in the prevention of leishmaniasis: a meta-analysis. Vacc- ine. 2009 30; 27(35):4747-53. Epub 2009 Jun 18. 13. Khatami A, Firooz A, Gorouhi F, Dowlati Y. Treatment of acute Old World cutaneous leishmaniasis: a sys- tematic review of the randomized con- trolled trials. J Am Acad Dermatol. 2007;57(2):335.e1-29. Epub 2007 Mar 6. 65 14. Modabber F, Buffet PA, Torreele E, Milon G, Croft SL. Consultative meeting to develop a strategy for treat- ment of cutaneous leishmaniasis. Institute Pasteur, Paris. 13-15 June, 2006. Kinetoplastid Biol Dis. 2007 Apr 24;6:3. 15. Buffet P, Caumes E, Gentilini M. [Treatment of localized cutaneous leishmaniasis]. Ann Dermatol Vener- eol. 1994; 121(6-7): 503-11. 16. Asilian A, Jalayer T, Whitworth JA, Ghasemi RL, Nilforooshzadeh M, Ol- liaro P. A randomized, placebo-con- trolled trial of a two-week regimen of aminosidine (paromomycin) ointment for treatment of cutaneous leishmani- asis in Iran. Am J Trop Med Hyg. 1995;53(6):648-51. 17. Shazad B, Abbaszadeh B, Khamesi- pour A. Comparison of topical paromomycin sulfate (twice/day) with intralesional meglumine antimoniate for the treatment of cutaneous leishmaniasis caused by L. major. Eur J Dermatol. 2005;15(2):85-7. 18. Grogl M, Schuster BG, Ellis WY, Berman JD. Successful topical treat- ment of murine cutaneous leishmani- asis with a combination of paromom- ycin (Aminosidine) and gentamicin. J Parasitol. 1999; 85(2):354-9. 19. Soto JM, Toledo JT, Gutierrez P, Arboleda M, Nicholls RS, Padilla JR, Berman JD, English CK, Grogl M. Treatment of cutaneous leishmaniasis with a topical antileishmanial drug (WR279396): phase 2 pilot study. Am J Trop Med Hyg. 2002;66(2):147-51.