Meta-analysis of PSA, DRE and TRUS 17. Muris JW, Starmans R, Wolfs GG, Pop P, Knottnerus JA. The diagnostic value of rectal examination. Fam Pract 1993;10:34-7. 18. Haid M, Rabin D, King KM, Feistein CM, Janson KL, Levine SR, et al. Digital rectal examination, serum prostate specific antigen, and prostatic ultrasound: How effective is this diagnostic triad? J Sur Onc 1994; 56:32-8. 19. Hoogendam A, Buntinx F, de Vet HC. The diagnostic value of digital rectal examination in primary care screening for prostate cancer: A meta-analysis. Fam Pract 1999;16:621-6. 20. Hoffman RM, Clanon DL, Littenberg B, Frank JJ, Peirce JC. Using the free-to-total prostate-specific antigen ratio to detect prostate cancer in men with nonspecific eleva- tions of prostate-specific antigen levels. J Gen Intern Med 2000;15:739-48. 21. Bunting PS. Screening for prostate cancer with prostate- specific antigen: beware the biases. Clin Chim Acta 2002;315:71-97. 22. Mistry K, Cable G. Meta-analysis of prostate-specific antigen and digital rectal examination as screening tests for prostate carcinoma. J Am Board Fam Pract 2003;16:95-101. 23. Hasselblad V, Hedges L. Meta-analysis of screening and diagnostic tests. Psychol Bull 1995;117:167-77. 24. Hasselblad V, McCrory DC. Meta-analytic tools for medical decision making: A practical guide. Med Decis Making 1995;15:81-96. 25. Song HH. Meta-analysis in medicine, nurse, and social science research. 1st ed. Seoul: Chungmoonkak Press; 1998. 26. Kang SG. The evaluation of prostate cancer: TRUS (transrectal ultrasonography of prostate), DRE (digital rectal examination), serum PSA (prostate specific antigen). [Thesis of Master Degree]. Daejeon: Graduate School, Chungnam National Univ.: 1991. 27. Kim TH, Lee JG, Cho JH. Predictability of PSA, DRE and TRUS for detection of prostatic cancer in con- sidering the non-surgical treatment of BPH patients. Korean J Urol 1994;35:736-42. 28. Park HK, Ahn HJ. Role of prostate specific antigen, digital rectal examination and transrectal ultrasound in the diagnosis of prostate cancer. Korean J Urol 1994;35: 27-32. 29. Byun HS. Comparative evaluation of diagnostic values of digital rectal examination, serum PSA level and transrectal ultrasonography. [Thesis of Master Degree]. Seoul: Graduate School of Korea Univ.: 1995. 30. Park SW, Oh KH. Early experience of transperineal prostatic biopsy under transrectal ultrasound guidance. Korean J Urol 1995;36:1076-84. 31. Choi JH, Park HJ, Kwon CH. Clinical value of prostatic biopsy in patients with elevated serum PSA. Korean J Urol 1996;37:1110-6. 32. Seo WK, Kim GH, Park CH, Lee SC. Prostate cancer detection in clinical urologic practice: Comparison of digital rectal examination, serum PSA level, and trans- rectal ultrasonography. Korean J Urol 1996;37:150-5. 33. Kim JH, Park HJ, Kwon CH. Detection of prostate cancer by digital rectal examination, serum PSA and transrectal ultrasonography. Korean J Urol 1998;39:472- 5. 34. Jung JY, Cho KS, Byeon SS, Kim KM, Paick JS, Lee SE. The value of prostate specific antigen density in the diagnosis of prostate adenocarcinoma. Korean J Urol 1998;39:355-60. 35. Yoon JH, Kim BH, Choi SH, Kim SH, Choi HY, Chai SE, et al. Usefulness of transrectal ultrasound in diagnosing prostate cancer: Comparison with digital rectal examination, prostate-specific antigen and pros- tate-specific antigen density. J Korean Radiol Soc 1998; 39:965-70. 36. Chang HJ, Sohn HG, Ha DB, Lee KS. Diagnostic value for early detection of prostate cancer of the digital rectal examination, serum prostate specific antigen and transrectal ultrasonography. Korean J Androl 1999;17: 39-43. 37. Kim JH, Chang SG, Kim YW. Pathologic diagnosis and clinical findings in patients undergoing transrectal prostatic biopsy. Korean J Urol 2000;41:492-9. 38. Jung BC, Kim TH, Jeong SJ, Kwak C, Lee SE. The clinical usefulness of the prostate-specific antigen, prostate-specific antigen density, digital rectal examina- tion, and transrectal ultrasonography in the screening test of prostate cancer in Koreans. Korean J Urol 2002; 43:14-8. 39. Moses LE, Shapiro D, Littenberg B. Combining inde- pendent studies of a diagnostic test into a summary ROC curve: Data-analytic approaches and some addi- tional consideration. Stat Med 1993;12:1293-316. 40. Potosky AL, Miller BA, Albertsen PC, Kramer BS. The role of increasing detection in the rising incidence of prostate cancer. JAMA 1995;273:548-52. 41. Kim CB. Clinical practice guidelines in Korea: Develop- ment and implementation. QA 2001;8:108-33. 42. Irwig L, Macaskill P, Glasziou P, Fahey M. Meta-an- alytic methods for diagnostic test accuracy. J Clin Epidemiol 1995;48:119-30. 43. Lijmer JG, Bossuyt PM, Heisterkamp SH. Exploring sources of heterogeneity in systematic reviews of diagnostic tests. Stat Med 2002;21:1525-37. 44. Cochrane Methods Working Group on Screening and Diagnostic Tests. Recommended methods. http://www. cochrane.org/cochrane/sadtdoc1.htm, 1996. 45. National Health and Medical Research Council. How to review the evidence: Systemic identification and review of the scientific literature. National Health and Medical Research Council, Canberra. 2000. 46. Hwang KH, Chung MK. Screening for prostatic cancers in Korean. Korean J Urol 1995;36:1062-70. 47. Yoon JH, Jung SI, Kim SI, Choi MS, Lee SH, Jung GW. Estimation of prostatic cancer prevalence in Korea: An epidemiological survey in Kangseo-Gu, Pusan. Korean J Urol 1998;39:994-1000. 48. Egger M, Smith G, Schneider M, Minder C. Bias in Yonsei Med J Vol. 46, No. 3, 2005