Se Joo Kim and Chan-Hyung Kim 17. Lipsitz JD, Mannuzza S, Chapman TF, Foa EB, Franklin ME, Goodwin RD, et al. A direct interview family study of obsessive-compulsive disorder. II. Contribu- tion of proband informant information. Psychol Med 2005;35:1623-31. 18. Nestadt G, Lan T, Samuels J, Riddle M, Bienvenu OJ, 3rd, Liang KY, et al. Complex segregation analysis pro- vides compelling evidence for a major gene underlying obsessive-compulsive disorder and for heterogeneity by sex. Am J Hum Genet 2000;67:1611-6. 19. Hanna GL, Fingerlin TE, Himle JA, Boehnke M. Complex segregation analysis of obsessive-compulsive disorder in families with pediatric probands. Hum Hered 2005;60:1-9. 20. Cavallini MC, Pasquale L, Bellodi L, Smeraldi E. Com- plex segregation analysis for obsessive compulsive dis- order and related disorders. Am J Med Genet 1999; 88:38-43. 21. Cavallini MC, Bertelli S, Chiapparino D, Riboldi S, Bellodi L. Complex segregation analysis of obsessive- compulsive disorder in 141 families of eating disorder probands, with and without obsessive-compulsive dis- order. Am J Med Genet 2000;96:384-91. 22. Alsobrook II JP, Leckman JF, Goodman WK, Rasmussen SA, Pauls DL. Segregation analysis of obsessive- compulsive disorder using symptom-based factor scores. Am J Med Genet 1999;88:669-75. 23. Nicolini H, Hanna GL, Baxter T, Schwartz J, Weisbecker K, Spence MA. Segregation analysis of obsessive- compulsive and associated disorders: preliminary results. Ursus Medicus 1991;1:25-8. 24. Weissbecker K, Baxter LR, Schwartz JM. Linkage analysis of obsessive-compulsive disorder. Cytogenet Cell Genet 1989;51:1105. 25. Hanna GL, Veenstra-VanderWeele J, Cox NJ, Boehnke M, Himle JA, Curtis GC, et al. Genome-wide linkage analysis of families with obsessive-compulsive disorder ascertained through pediatric probands. Am J Med Genet 2002;114:541-52. 26. Willour VL, Yao Shugart Y, Samuels J, Grados M, Cullen B, Bienvenu OJ 3rd, et al. Replication study supports evidence for linkage to 9p24 in obsessive-com- pulsive disorder. Am J Hum Genet 2004;75:508-13. 27. Shugart YY, Samuels J, Willour VL, Grados MA, Greenberg BD, Knowles JA, et al. Genomewide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q. Mol Psychiatry 2006;11:763-70. 28. Hemmings SM, Kinnear CJ, Niehaus DJ, Moolman- Smook JC, Lochner C, Knowles JA, et al. Investigating the role of dopaminergic and serotonergic candidate genes in obsessive-compulsive disorder. Eur Neuro- psychopharmacol 2003;13:93-8. 29. Marazziti D, Rossi A, Gemignani A, Giannaccini G, Pfanner C, Milanfranchi A, et al. Decreased platelet 3H- paroxetine binding in obsessive-compulsive patients. Neuropsychobiology 1996;34:184-7. 30. Zohar J, Insel TR. Obsessive-compulsive disorder: Yonsei Med J Vol. 47, No. 4, 2006 psychobiological approaches to diagnosis, treatment, and pathophysiology. Biol Psychiatry 1987;22:667-87. 31. Pigott TA, Zohar J, Hill JL, Bernstein SE, Grover GN, Zohar-Kadouch RC, et al. Metergoline blocks the behavioral and neuroendocrine effects of orally admin- istered m-chlorophenylpiperazine in patients with obsessive-compulsive disorder. Biol Psychiatry 1991;29: 418-26. 32. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, et al. Allelic variation of human serotonin trans- porter gene expression. J Neurochem 1996;66:2621-4. 33. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996;274:1527-31. 34. McDougle CJ, Epperson CN, Price LH, Gelernter J. Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive com- pulsive disorder. Mol Psychiatry 1998;3:270-3. 35. Bengel D, Greenberg BD, Cora-Locatelli G, Altemus M, Heils A, Li Q, et al. Association of the serotonin trans- porter promoter regulatory region polymorphism and obsessive-compulsive disorder. Mol Psychiatry 1999;4: 463-6. 36. Kinnear CJ, Niehaus DJ, Moolman-Smook JC, du Toit PL, van Kradenberg J, Weyers JB, et al. Obsessive-com- pulsive disorder and the promoter region polymor- phism (5-HTTLPR) in the serotonin transporter gene (SLC6A4): a negative association study in the Afrikaner population. Int J Neuropsychopharmacol 2000;3:327-31. 37. Camarena B, Rinetti G, Cruz C, Hernandez S, de la Fuente JR, Nicolini H. Association study of the sero- tonin transporter gene polymorphism in obsessive- compulsive disorder. Int J Neuropsychopharmacol 2001;4:269-72. 38. Frisch A, Michaelovsky E, Rockah R, Amir I, Hermesh H, Laor N, et al. Association between obsessive-com- pulsive disorder and polymorphisms of genes encoding components of the serotonergic and dopaminergic pathways. Eur Neuropsychopharmacol 2000;10:205-9. 39. Walitza S, Wewetzer C, Gerlach M, Klampfl K, Geller F, Barth N, et al. Transmission disequilibrium studies in children and adolescents with obsessive-compulsive disorders pertaining to polymorphisms of genes of the serotonergic pathway. J Neural Transm 2004;111:817-25. 40. Chabane N, Millet B, Delorme R, Lichtermann D, Mathieu F, Laplanche JL, et al. Lack of evidence for association between serotonin transporter gene (5- HTTLPR) and obsessive-compulsive disorder by case control and family association study in humans. Neurosci Lett 2004;363:154-6. 41. Di Bella D, Erzegovesi S, Cavallini MC, Bellodi L. Obsessive-compulsive disorder, 5-HTTLPR polymor- phism and treatment response. Pharmacogenomics J 2002;2:176-81. 42. Kim SJ, Lee HS, Kim CH. Obsessive-compulsive dis- order, factor-analyzed symptom dimensions and serotonin transporter polymorphism. Neuropsychobio-