Species-specific AhR-mediated developmental toxicity Marlowe JL, Puga A. 2005. Aryl hydrocarbon receptor, cell cycle regulation, toxicity, and tumorigenesis. J Cell Biochem 96:1174–1184. Moors M, Cline JE, Abel J, Fritsche E. 2007. ERK-dependent and -independent pathways trigger human neural progenitor cell migration. Toxicol Appl Pharmacol 221:57–67. Moors M, Rockel TD, Abel J, Cline JE, Gassmann K, Schreiber T, et al. 2009. Human neurospheres as three-dimensional cellular systems for developmental neurotoxicity testing. Environ Health Perspect 117:1131–1138. Mulero-Navarro S, Pozo-Guisado E, Perez-Mancera PA, Varez- Barrientos A, Catalina-Fernandez I, Hernandez-Nieto E, et al. 2005. Immortalized mouse mammary fibroblasts lacking dioxin receptor have impaired tumorigenicity in a subcutaneous mouse xenograft model. J Biol Chem 280:28731–28741. National Research Council. 2007. Toxicity Testing in the 21st Century: A Vision and a Strategy. Washington, DC:National Academy Press. Olds DL, Henderson CR Jr, Tatelbaum R. 1994. Intellectual impairment in children of women who smoke cigarettes during pregnancy. Pediatrics 93:221–227. Pang PH, Lin YH, Lee YH, Hou HH, Hsu SP, Juan SH. 2008. Molecular mechanisms of p21 and p27 induction by 3-methylcholanthrene, an aryl-hydrocarbon receptor ago- nist, involved in antiproliferation of human umbilical vas- cular endothelial cells. J Cell Physiol 215:161–171. Patandin S, Lanting CI, Mulder PG, Boersma ER, Sauer PJ, Weisglas-Kuperus N. 1999. Effects of environmental expo- sure to polychlorinated biphenyls and dioxins on cognitive abilities in Dutch children at 42 months of age. J Pediatr 134:33–41. Polanska K, Hanke W, Sobala W, Brzeznicki S, Ligocka D. 2009. Exposure of smoking pregnant women to polycyclic aro- matic hydrocarbons [in Polish]. Med Pr 60:103–108. Qin H, Powell-Coffman JA. 2004. The Caenorhabditis elegans aryl hydrocarbon receptor, AHR-1, regulates neuronal development. Dev Biol 270:64–75. Reiners JJ Jr, Clift R, Mathieu P. 1999. Suppression of cell cycle progression by flavonoids: dependence on the aryl hydro- carbon receptor. Carcinogenesis 20:1561–1566. Reyes H, Reisz-Porszasz S, Hankinson O. 1992. Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor. Science 256:1193–1195. Rodgman A, Smith CJ, Perfetti TA. 2000. The composition of cigarette smoke: a retrospective, with emphasis on poly- cyclic components. Hum Exp Toxicol 19:573–595. Rozen S, Skaletsky HJ. 2000. Primer3 on the WWW for general users and for biologist programmers. In: Bioinformatics Methods and Protocols: Methods in Molecular Biology (Krawetz S, Misener S, eds). Totowa, NJ:Humana Press, 365–386. Schreiber T, Gassmann K, Götz C, Hübenthal U, Moors M, Krause G, et al. 2010. Polybrominated diphenyl ethers induce developmental neurotoxicity in a human in vitro model: evidence for endocrine disruption. Environ Health Perpect 118:572–578. Seifert A, Rau S, Kullertz G, Fischer B, Santos AN. 2009. TCDD induces cell migration via NFATc1/ATX-signaling in MCF-7 cells. Toxicol Lett 184:26–32. Thapar A, Fowler T, Rice F, Scourfield J, van den BM, Thomas H, et al. 2003. Maternal smoking during pregnancy and atten- tion deficit hyperactivity disorder symptoms in offspring. Am J Psychiatry 160:1985–1989. Weissman MM, Warner V, Wickramaratne PJ, Kandel DB. 1999. Maternal smoking during pregnancy and psycho- pathology in offspring followed to adulthood. J Am Acad Child Adolesc Psychiatry 38:892–899. Williamson MA, Gasiewicz TA, Opanashuk LA. 2005. Aryl hydro- carbon receptor expression and activity in cerebellar granule neuroblasts: implications for developmental and dioxin neurotoxicity. Toxicol Sci 83:340–348. Wong PS, Li W, Vogel CF, Matsumura F. 2009. Characterization of MCF mammary epithelial cells overexpressing the arylhydrocarbon receptor (AhR). BMC Cancer 9:234; doi:10.1186/1471-2407-9-234 [Online 15 July 2009]. Wormley DD, Ramesh A, Hood DB. 2004. Environmental contaminant-mixture effects on CNS development, plastic- ity, and behavior. Toxicol Appl Pharmacol 197:49–65. Zoeller RT, Crofton KM. 2000. Thyroid hormone action in fetal brain development and potential for disruption by environ- mental chemicals. Neurotoxicology 21:935–945. Environmental Health Perspectives • volume 118 | number 11 | November 2010 1577