Pharmacokinetics of mycophenolic acid and its phenyl glucuronide metabolite in kidney transplant recipients with renal impairment Table V. Multivariate analysis of clinical parameters influencing MPA PK parameters Independent variables Relation Partial value of p Model value of p MPA C0 [mg/l] Sex [men/women] NS 0.138 0.003 CNI [CsA/Tac] NS 0.064 MMF dose [g] Positive 0.022 Ccr [ml/min] Negative 0.008 MPA C0 [mg/l] MMF dose [g] NS 0.075 0.033 Ccr [ml/min] NS 0.055 Proteinuria [yes/no] NS 0.562 MPA AUC0-4 h [mg × h/l] Sex [men/women] Positive 0.017 < 0.001 MMF dose [g] Positive < 0.001 Ccr [ml/min] NS 0.694 MPA AUC0-4 h [mg × h/l] MMF dose [g] Positive < 0.001 0.001 Ccr [ml/min] NS 0.420 Proteinuria [yes/no] NS 0.682 MPA Cmax [mg/l] Body weight [kg] NS 0.055 0.007 MMF dose [g] Positive 0.002 Ccr [ml/min] Positive 0.039 MPA Cmax [mg/l] MMF dose [g] Positive 0.001 0.003 Ccr [ml/min] Positive 0.046 Proteinuria [yes/no] NS 0.372 MPA C0 /dose [mg/l/g] Sex [men/women] NS 0.173 < 0.001 CNI [CsA/Tac] Negative 0.007 Ccr [ml/min] Negative 0.004 MPA C0 /dose [mg/l/g] Ccr [ml/min] Negative 0.042 0.098 Proteinuria [yes/no] NS 0.792 MPA AUC0-4 h/dose [mg × h/l/g] Sex [men/women] Positive 0.017 0.015 CNI [CsA/Tac] NS 0.061 Ccr [ml/min] NS 0.613 MPA AUC0-4 h/dose [mg × h/l/g] Ccr [ml/min] NS 0.565 0.582 Proteinuria [yes/no] NS 0.466 MPA Cmax/dose [mg/l] Body weight [kg] Negative 0.012 0.036 Ccr [ml/min] NS 0.055 Model R coefficient 0.544 0.435 0.593 0.569 0.438 0.532 0.565 0.323 0.449 0.159 0.332 Arch Med Sci 1, February / 2012 93