4 [12] R. L. Chevalier, “Obstructive nephropathy: towards biomarker discovery and gene therapy,” Nature Clinical Practice Nephrol- ogy, vol. 2, no. 3, pp. 157–168, 2006. [13] W. Y. Huang, C. A. Peters, D. Zurakowski et al., “Renal biopsy in congenital ureteropelvic junction obstruction: evidence for parenchymal maldevelopment,” Kidney International, vol. 69, no. 1, pp. 137–143, 2006. [14] B. A. Thornhill, L. E. Burt, C. Chen, M. S. Forbes, and R. L. Chevalier, “Variable chronic partial ureteral obstruction in the neonatal rat: a new model of ureteropelvic junction obstruction,” Kidney International, vol. 67, no. 1, pp. 42–52, 2005. [15] N. Kawada, T. Moriyama, A. Ando et al., “Increased oxidative stress in mouse kidneys with unilateral ureteral obstruction,” Kidney International, vol. 56, no. 3, pp. 1004–1013, 1999. [16] R. L. Chevalier, B. A. Thornhill, M. S. Forbes, and S. C. Kiley, “Mechanisms of renal injury and progression of renal disease in congenital obstructive nephropathy,” Pediatric Nephrology, vol. 25, no. 4, pp. 687–697, 2010. [17] R. L. Chevalier, A. Kim, B. A. Thornhill, and J. T. Wol- stenholme, “Recovery following relief of unilateral ureteral obstruction in the neonatal rat,” Kidney International, vol. 55, no. 3, pp. 793–807, 1999. [18] R. L. Chevalier, M. S. Forbes, and B. A. Thornhill, “Ureteral obstruction as a model of renal interstitial ﬁbrosis and obstructive nephropathy,” Kidney International, vol. 75, no. 11, pp. 1145–1152, 2009. [19] B. L. Warshaw, H. H. Edelbrock, R. B. Ettenger et al., “Renal transplantation in children with obstructive uropathy,” Journal of Urology, vol. 123, no. 5, pp. 737–741, 1980. [20] D. I. Williams and H. B. Eckstein, “Obstructive valves in the posterior urethra,” Journal of Urology, vol. 93, pp. 236–246, 1965. [21] D. H. Frohneberg, J. W. Thuroﬀ, and H. Riedmiller, “Posterior urethral valves: theoretical considerations on embryological development,” European Urology, vol. 8, no. 6, pp. 325–328, 1982. [22] A. Krishnan, A. de Souza, R. Konijeti, and L. S. Baskin, “The anatomy and embryology of posterior urethral valves,” Journal of Urology, vol. 175, no. 4, pp. 1214–1220, 2006. [23] O. S. Lowsley, “Congenital malformation of the posterior urethra,” Annals of Surgery, vol. 60, no. 6, pp. 733–741, 1914. [24] E. M. Watson, “The regulatory function of the kidney in nephritis,” Canadian Medical Association Journal, vol. 12, no. 9, pp. 616–617, 1922. [25] L. D. Jee, A. M. K. Rickwood, and R. R. Turnock, “Posterior urethral valves. Does prenatal diagnosis inﬂuence prognosis?” British Journal of Urology, vol. 72, no. 5, pp. 830–833, 1993. [26] L. D. Jee, A. M. K. Rickwood, M. P. L. Williams, P. A. M. Anderson, and J. Mandell, “Experience with duplex system anomalies detected by prenatal ultrasonography,” Journal of Urology, vol. 149, no. 4, pp. 808–810, 1993. [27] K. A. R. Hutton, “Posterior urethral valves,” British Journal of Urology, vol. 74, no. 1, p. 134, 1994. [28] K. A. R. Hutton, D. F. M. Thomas, R. J. Arthur, H. C. Irving, and S. E. W. Smith, “Prenatally detected posterior urethral valves: is gestational age at detection a predictor of outcome?” Journal of Urology, vol. 152, no. 2, pp. 698–701, 1994. [29] S. Pathak and C. Lees, “Ultrasound structural fetal anomaly screening: an update,” Archives of Disease in Childhood: Fetal and Neonatal Edition, vol. 94, no. 5, pp. F384–F390, 2009. [30] R. J. Stiller, “Early ultrasonic appearance of fetal bladder outlet obstruction,” American Journal of Obstetrics and Gynecology, vol. 160, no. 3, pp. 584–585, 1989. International Journal of Nephrology [31] E. Z. Zimmer and M. Bronshtein, “Fetal intra-abdominal cysts detected in the ﬁrst and early second trimester by transvaginal sonography,” Journal of Clinical Ultrasound, vol. 19, no. 9, pp. 564–567, 1991. [32] T. J. Clark, W. L. Martin, T. G. Divakaran, M. J. Whittle, M. D. Kilby, and K. S. Khan, “Prenatal bladder drainage in the man- agement of fetal lower urinary tract obstruction: a systematic review and meta-analysis,” Obstetrics and Gynecology, vol. 102, no. 2, pp. 367–382, 2003. [33] P. D. Furness III, M. Maizels, S. W. Han, R. A. Cohn, and E. Y. Cheng, “Elevated bladder urine concentration of transforming growth factor-β1 correlates with upper urinary tract obstruction in children,” Journal of Urology, vol. 162, no. 3, pp. 1033–1036, 1999. [34] G. Grandaliano, L. Gesualdo, F. Bartoli et al., “MCP-1 and EGF renal expression and urine excretion in human congenital obstructive nephropathy,” Kidney International, vol. 58, no. 1, pp. 182–192, 2000. [35] S. Decramer, S. Wittke, H. Mischak et al., “Predicting the clin- ical outcome of congenital unilateral ureteropelvic junction obstruction in newborn by urinary proteome analysis,” Nature Medicine, vol. 12, no. 4, pp. 398–400, 2006. [36] M. R. Harrison, M. S. Golbus, and R. A. Filly, “Fetal surgery for congenital hydronephrosis,” The New England Journal of Medicine, vol. 306, no. 10, pp. 591–593, 1982. [37] J. S. Elder, J. W. Duckett Jr., and H. M. Snyder, “Intervention for fetal obstructive uropathy: has it been eﬀective?” The Lancet, vol. 2, no. 8566, pp. 1007–1009, 1987. [38] G. McLorie, W. Farhat, A. Khoury, D. Geary, and G. Ryan, “Outcome analysis of vesicoamniotic shunting in a compre- hensive population,” Journal of Urology, vol. 166, no. 3, pp. 1036–1040, 2001. [39] R. A. Quintero, M. P. Johnson, R. Romero et al., “In-utero percutaneous cystoscopy in the management of fetal lower obstructive uropathy,” The Lancet, vol. 346, no. 8974, pp. 537– 540, 1995. [40] R. A. Quintero, A. R. Shukla, Y. L. Homsy, and R. Bukkap- atnam, “Successful in utero endoscopic ablation of posterior urethral valves: a new dimension in fetal urology,” Urology, vol. 55, no. 5, p. 774, 2000. [41] R. K. Morris and M. D. Kilby, “An overview of the literature on congenital lower urinary tract obstruction and introduction to the PLUTO trial: percutaneous shunting in lower urinary tract obstruction,” Australian and New Zealand Journal of Obstetrics and Gynaecology, vol. 49, no. 1, pp. 6–10, 2009. [42] H. Kitagawa, K. C. Pringle, J. Koike et al., “The early eﬀects of urinary tract obstruction on glomerulogenesis,” Journal of Pediatric Surgery, vol. 39, no. 12, pp. 1845–1848, 2004.