Jolanta Kamińska, Maciej Głyda, Joanna Sobiak, Maria Chrzanowska Table V. Cont. Independent variables MPA Cmax/dose [mg/l] Ccr [ml/min] Proteinuria [yes/no] Relation Partial value of p Model value of p Model R coefficient NS NS 0.061 0.307 0.066 0.349 MPA – mycophenolic acid, PK – pharmacokinetic, C0 – pre-dose concentration, NS – not significant, CNI – calcineurin inhibitor, CsA – cyclosporine, Tac – tacrolimus, MMF – mycophenolate mofetil, Ccr – creatinine clearance, AUC – area under the concentration-time curve, Cmax – maximum concentration Table VI. Multivariate analysis of clinical parameters influencing MPAG PK parameters Independent variables Relation Partial value of p Model value of p MPAG C0 [mg/l] Sex [men/women] Positive < 0.001 < 0.001 Body weight [kg] Positive < 0.001 MMF dose [g] Positive < 0.001 Ccr [ml/min] Negative < 0.001 MPAG C0 [mg/l] MMF dose [g] Positive < 0.001 < 0.001 Ccr [ml/min] Negative < 0.001 Proteinuria [yes/no] NS 0.191 MPAG AUC0-4 h [mg × h/l] Sex [men/women] Positive < 0.001 < 0.001 Body weight [kg] Positive < 0.001 MMF dose [g] Positive < 0.001 Ccr [ml/min] Negative < 0.001 MPAG AUC0-4 h [mg × h/l] MMF dose [g] Positive < 0.001 < 0.001 Ccr [ml/min] Negative < 0.001 Proteinuria [yes/no] NS 0.526 MPAG Cmax [mg/l] Sex [men/women] Positive < 0.001 < 0.001 Body weight [kg] Positive < 0.001 MMF dose [g] Positive < 0.001 Ccr [ml/min] Negative < 0.001 MPAG Cmax [mg/l] MMF dose [g] Positive < 0.001 < 0.001 Ccr [ml/min] Negative 0.001 Proteinuria [yes/no] NS 0.689 MPAG C0/dose [mg/l/g] Sex [men/women] Positive < 0.001 < 0.001 Body weight [kg] Positive < 0.001 CNI [CsA/Tac] Positive 0.047 Ccr [ml/min] Negative < 0.001 MPAG C0/dose [mg/l/g] Ccr [ml/min] Negative < 0.001 < 0.001 Proteinuria [yes/no] NS 0.130 Model R coefficient 0.842 0.704 0.847 0.681 0.832 0.651 0.873 0.661 94 Arch Med Sci 1, February / 2012