Shatoor et al bit lungs. J Cardiovasc Pharmacol. 1988;12(1):23-36. 10. Leeder RG, Brien JF, Massey TE. Investigation of the role of oxidative stress in amiodarone-induced pulmo- nary toxicity in the hamster. Can J Physiol Pharmacol. 1994;72(6):613-621. 11. Schwaiblmair M, Berghaus T, Haeckel T, Wagner T, von Scheidt W. Amiodarone-induced pulmonary toxicity: an under-recognized and severe adverse effect? Clin Res Cardiol. 2010;99(11):693-700. 12. John, M., Dovie, O.D., Andrew, S. and Gurwood, O.D. (2006). Acute onset of halos and glare bilateralcorneal epithelial edema with cystic eruptionsatypical presenta- tion of amiodarone keratopathy. J. Am. Optomet. Assoc. 77(2): 76-81. 13. Russell SJ, Saltissi S. Amiodarone induced skin necro- sis. Heart. 2006;92(10):1395. 14. Harjai KJ, Licata AA. Effects of amiodarone on thyroid function. Ann Intern Med. 1997;126(1):63-73. 15. Fromenty B, Fisch C, Berson A, Letteron P, Larrey D, Pessayre D. Dual effect of amiodarone on mitochondrial respiration. Initial protonophoric uncoupling effect fol- lowed by inhibition of the respiratory chain at the lev- els of complex I and complex II. J Pharmacol Exp Ther. 1990;255(3):1377-1384. 16. Fromenty B, Fisch C, Labbe G, Degott C, Deschamps D, Berson A, Letteron P, et al. Amiodarone inhibits the mitochondrial beta-oxidation of fatty acids and produces microvesicular steatosis of the liver in mice. J Pharma- col Exp Ther. 1990;255(3):1371-1376. 17. Lewis JH, Mullick F, Ishak KG, Ranard RC, Ragsdale B, Perse RM, Rusnock EJ, et al. Histopathologic analy- sis of suspected amiodarone hepatotoxicity. Hum Pathol. 1990;21(1):59-67. 18. Spaniol M, Bracher R, Ha HR, Follath F, Krahen- buhl S. Toxicity of amiodarone and amiodarone ana- logues on isolated rat liver mitochondria. J Hepatol. 2001;35(5):628-636. 19. Zaki MS, Eid RA. Role of vitamin-E on rat liver-amio- darone: an ultrastructural study. Saudi J Gastroenterol. 2009;15(2):104-110. 20. Zidan, Rania Ahmad. (2011). Effect of long-term ad- ministration of amiodarone on rat lung and the pos- sible protective role of vitamin E: a histological and immunohistochemical study. The Egyptian Jour- nal of Histology. 34(1): 117–128 doi: 10.1097/01. EHX.0000395190.66459.04. 21. Paget GE, Barnes JM. (1964). Evaluation of drug activi- ties and pharmacometrics. In: Laurence DR, Bacjarab AL, editors. Evaluation of drug activities. Vol. 1. Lon- don and N.Y: Academic Press. pp. 135–66. 22. Calfee-Mason KG, Spear BT, Glauert HP. Vitamin E inhibits hepatic NF-kappaB activation in rats adminis- tered the hepatic tumor promoter, phenobarbital. J Nutr. 2002;132(10):3178-3185. J Clin Med Res • 2012;4(3):190-196 23. National Research Council. (1996). Guide for the Care and Use of Laboratory Animals. National Academy Press. Washington, U. S. A, pp. 1-7. 24. Bancroft JD, Stevens A. (1996): Theory and practice of histological techniques, 4thed. New York. Edinburgh. London: Churchill Livingstone, pp. 175–190. 25. Kamiya K, Nishiyama A, Yasui K, Hojo M, Sanguinetti MC, Kodama I. Short- and long-term effects of amioda- rone on the two components of cardiac delayed rectifier K(+) current. Circulation. 2001;103(9):1317-1324. 26. Greene HL, Graham EL, Werner JA, Sears GK, Gross BW, Gorham JP, Kudenchuk PJ, et al. Toxic and thera- peutic effects of amiodarone in the treatment of cardiac arrhythmias. J Am Coll Cardiol. 1983;2(6):1114-1128. 27. Mason JW.Amiodarone. N Engl J Med. 1987;316(8):455- 466. 28. Card JW, Leeder RG, Racz WJ, Brien JF, Bray TM, Massey TE. Effects of dietary vitamin E supplementa- tion on pulmonary morphology and collagen deposition in amiodarone- and vehicle-treated hamsters. Toxicol- ogy. 1999;133(2-3):75-84. 29. Priceh M. (1973). Ultrastructural pathologic characteris- tics of the skeletal muscle fiber: An introductory survey. In: The Striated Muscle, ed. Pearson and Mostofi, Wil- liams and Wilkins, Baltimore, pp. 144-184. 30. Ghadiallfy. N. (1975). Ultrastructural Pathology of the Cell. A Text and Atlas of Physiological and Pathological Alterations in Cell Fine Structure, Butteworth, Boston, pp. 10 1-1 86. 31. Trumpb, F., Arstilaa,. U. (1975). Cellular reaction to in- jury. In: Principles of Pathobiology, 2nd ed, ed. LaVia and Hill, Oxford University Press, New York, pp. 9-96. 32. Lenaz G. Role of mitochondria in oxidative stress and ageing. Biochim Biophys Acta. 1998;1366(1-2):53-67. 33. Ferrans VJ, Buja LM, Maron BJ. Sarcolemmal altera- tions in cardiac hypertrophy and degeneration. Recent Adv Stud Cardiac Struct Metab. 1976;9:395-419. 34. Schaper J, Froede R, Hein S, Buck A, Hashizume H, Speiser B, Friedl A, et al. Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy. Circulation. 1991;83(2):504-514. 35. Mifune H, Suzuki S, Noda Y, Mohri S, Mochizuki K. Fine structure of atrial natriuretic peptide(ANP)-gran- ules in the atrial cardiocytes in the pig, cattle and horse. J Vet Med Sci. 1991;53(4):561-568. 36. Mifune H, Suzuki S, Noda Y, Hayashi Y, Mochizuki K. Fine structure of atrial natriuretic peptide (ANP)-gran- ules in the atrial cardiocytes in the hamster, guinea pig, rabbit, cat and dog. Jikken Dobutsu. 1992;41(3):321- 328. 37. Mifune H, Suzuki S, Nokihara K, Noda Y. Distribution of immunoreactive atrial and brain natriuretic peptides in the heart of the chicken, quail, snake and frog. Exp Anim. 1996;45(2):125-133. Articles © The authors | Journal compilation © J Clin Med Res and Elmer Press™ | www.jocmr.org 195