12 Journal of Proteome Research, vol. 8, no. 3, pp. 1585–1593, 2009. [81] Z. X. Cheng, B. R. Liu, X. P. Qian et al., “Proteomic analysis of anti-tumor eﬀects by Rhizoma Paridis total saponin treatment in HepG2 cells,” Journal of Ethnopharmacology, vol. 120, no. 2, pp. 129–137, 2008. [82] P. Y. K. Yue, D. Y. L. Wong, W. Y. Ha et al., “Elucidation of the mechanisms underlying the angiogenic eﬀects of ginsenoside Rg1 in vivo and in vitro,” Angiogenesis, vol. 8, no. 3, pp. 205– 216, 2005. [83] V. B. Konkimalla, M. Blunder, B. Korn et al., “Eﬀect of artemisinins and other endoperoxides on nitric oxide-related signaling pathway in RAW 264.7 mouse macrophage cells,” Nitric Oxide, vol. 19, no. 2, pp. 184–191, 2008. [84] S. Y. Su, C. Y. Cheng, T. H. Tsai, C. Y. Hsiang, T. Y. Ho, and C. L. Hsieh, “Paeonol attenuates H2O2-induced NF-κB- associated amyloid precursor protein expression,” American Journal of Chinese Medicine, vol. 38, no. 6, pp. 1171–1192, 2010. [85] X. Wang, Y. Wang, M. Jiang et al., “Diﬀerential cardiopro- tective eﬀects of salvianolic acid and tanshinone on acute myocardial infarction are mediated by unique signaling pathways,” Journal of Ethnopharmacology, vol. 135, no. 3, pp. 662–671, 2011. [86] W. Y. Lo, F. J. Tsai, C. H. Liu et al., “Uncaria rhynchophylla upregulates the expression of MIF and cyclophilin A in kainic acid-induced epilepsy rats: a proteomic analysis,” American Journal of Chinese Medicine, vol. 38, no. 4, pp. 745–759, 2010. [87] Y. C. Hung, P. W. Wang, and T. L. Pan, “Functional proteomics reveal the eﬀect of Salvia miltiorrhiza aqueous extract against vascular atherosclerotic lesions,” Biochimica et Biophysica Acta, vol. 1804, no. 6, pp. 1310–1321, 2010. [88] Y. C. Hung, P. W. Wang, T. L. Pan, G. Bazylak, and Y. L. Leu, “Proteomic screening of antioxidant eﬀects exhibited by Radix Salvia miltiorrhiza aqueous extract in cultured rat aortic smooth muscle cells under homocysteine treatment,” Journal of Ethnopharmacology, vol. 124, no. 3, pp. 463–474, 2009. [89] H. Zhao, R. Mortezaei, Y. Wang, X. Sheng, F. Aria, and K. Bojanowski, “SBD.4 stimulates regenerative processes in vitro, and wound healing in genetically diabetic mice and in human skin/severe-combined immunodeﬁciency mouse chimera,” Wound Repair and Regeneration, vol. 14, no. 5, pp. 593–601, 2006. [90] C. Prost-Squarcioni, S. Fraitag, M. Heller, and N. Boehm, “Functional histology of dermis,” Annales De Dermatologie Et De Venereologie, vol. 135, no. 1, Part 2, pp. 1–20, 2008. [91] A. R. Saltiel, “New perspectives into the molecular pathogen- esis and treatment of type 2 diabetes,” Cell, vol. 104, no. 4, pp. 517–529, 2001. [92] R. S. Lindsay, T. Funahashi, R. L. Hanson et al., “Adiponectin and development of type 2 diabetes in the Pima Indian population,” The Lancet, vol. 360, no. 9326, pp. 57–58, 2002. [93] Y. Fu, N. Luo, R. L. Klein, and W. T. Garvey, “Adiponectin promotes adipocyte diﬀerentiation, insulin sensitivity, and lipid accumulation,” Journal of Lipid Research, vol. 46, no. 7, pp. 1369–1379, 2005. [94] J. W. Hsu, H. C. Huang, S. T. Chen, C. H. Wong, and H. F. Juan, “Ganoderma lucidum polysaccharides induce macrophage-like diﬀerentiation in human leukemia THP- 1 cells via caspase and p53 activation,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 358717, 13 pages, 2011. Evidence-Based Complementary and Alternative Medicine [95] J. Jiang, I. Eliaz, and D. Sliva, “Suppression of growth and invasive behavior of human prostate cancer cells by ProstaCaid: mechanism of activity,” International Journal of Oncology, vol. 38, no. 6, pp. 1675–1682, 2011. [96] J. Jiang and D. Sliva, “Novel medicinal mushroom blend suppresses growth and invasiveness of human breast cancer cells,” International Journal of Oncology, vol. 37, no. 6, pp. 1529–1536, 2010. [97] S. M. Y. Lee, M. L. Y. Li, Y. C. Tse et al., “Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway,” Life Sciences, vol. 71, no. 19, pp. 2267–2277, 2002. [98] H. Li, N. Takai, A. Yuge et al., “Novel target genes responsive to the anti-growth activity of triptolide in endometrial and ovarian cancer cells,” Cancer Letters, vol. 297, no. 2, pp. 198– 206, 2010. [99] A. N. Pham, P. E. Blower, O. Alvarado, R. Ravula, P. W. Gout, and Y. Huang, “Pharmacogenomic approach reveals a role for the xc-cystine/glutamate antiporter in growth and celastrol resistance of glioma cell lines,” Journal of Pharmacology and Experimental Therapeutics, vol. 332, no. 3, pp. 949–958, 2010. [100] E. Wang, S. Bussom, J. Chen et al., “Interaction of a tra- ditional Chinese Medicine (PHY906) and CPT-11 on the inﬂammatory process in the tumor microenvironment,” BMC Medical Genomics, vol. 4, article 38, 2011. [101] J. H. Yoo, H. C. Kwon, Y. J. Kim, J. H. Park, and H. O. Yang, “KG-135, enriched with selected ginsenosides, inhibits the proliferation of human prostate cancer cells in culture and inhibits xenograft growth in athymic mice,” Cancer Letters, vol. 289, no. 1, pp. 99–110, 2010. [102] S. P. Hussain, G. E. Trivers, L. J. Hofseth et al., “Nitric oxide, a mediator of inﬂammation, suppresses tumorigenesis,” Cancer Research, vol. 64, no. 19, pp. 6849–6853, 2004. [103] J. X. Kang, J. Liu, J. Wang, C. He, and F. P. Li, “The extract of huanglian, a medicinal herb, induces cell growth arrest and apoptosis by upregulation of interferon-β and TNF-α in human breast cancer cells,” Carcinogenesis, vol. 26, no. 11, pp. 1934–1939, 2005. [104] L. S. Chan, P. Y. K. Yue, N. K. Mak, and R. N. S. Wong, “Role of MicroRNA-214 in ginsenoside-Rg1-induced angio- genesis,” European Journal of Pharmaceutical Sciences, vol. 38, no. 4, pp. 370–377, 2009. [105] H. Yaoita, K. Ogawa, K. Maehara, and Y. Maruyama, “Apop- tosis in relevant clinical situations: contribution of apoptosis in myocardial infarction,” Cardiovascular Research, vol. 45, no. 3, pp. 630–641, 2000. [106] K. Ito, X. Yan, M. Tajima, Z. Su, W. H. Barry, and B. H. Lorell, “Contractile reserve and intracellular calcium regulation in mouse myocytes from normal and hypertrophied failing hearts,” Circulation Research, vol. 87, no. 7, pp. 588–595, 2000. [107] D. Pratico` , “Oxidative stress hypothesis in Alzheimer’s dis- ease: a reappraisal,” Trends in Pharmacological Sciences, vol. 29, no. 12, pp. 609–615, 2008. [108] F. Wang, R. Ma, and L. Yu, “Role of mitochondria and mitochondrial cytochrome c in tubeimoside I-mediated apoptosis of human cervical carcinoma HeLa cell line,” Cancer chemotherapy and pharmacology., vol. 57, no. 3, pp. 389–399, 2006. [109] J. Lee, D. Son, P. Lee et al., “Protective eﬀect of methanol extract of Uncaria rhynchophylla against excitotoxicity induced by N-methyl-D-aspartate in rat hippocampus,” Journal Pharmacological Sciences, vol. 92, no. 1, pp. 70–73, 2003.