exposure to traffic particles. Am J Respir Crit Care Med Hernan MA, Lanoy E, Costagliola D, Robins JM. 2006. Pope CA III, Burnett RT, Thurston GD, Thun MJ, Calle EE, 179(7):572–578. nism, and function. Cell 116(2):281–297. Bartel DP. 2004. MicroRNAs: genomics, biogenesis, mecha- Comparison of dynamic treatment regimes via inverse probability weighting. Basic Clin Pharmacol Toxicol 98(3):237–242. Krewski D, et al. 2004. Cardiovascular mortality and long- term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of dis- Bartoli CR, Wellenius GA, Diaz EA, Lawrence J, Coull BA, Hoffmann B, Moebus S, Mohlenkamp S, Stang A, Lehmann N, ease. Circulation 109(1):71–77. Akiyama I, et al. 2009. Mechanisms of inhaled fine particu- late air pollution-induced arterial blood pressure changes. Environ Health Perspect 117:361–366. Dragano N, et al. 2007. Residential exposure to traffic is associated with coronary atherosclerosis. Circulation 116(5):489–496. Rao PK, Toyama Y, Chiang HR, Gupta S, Bauer M, Medvid R, et al. 2009. Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ Res Bell B, Rose CL, Damon A. 1966. The Veterans Administration lon- Horikawa Y, Wood CG, Yang H, Zhao H, Ye Y, Gu J, et al. 2008. 105(6):585–594. gitudinal study of healthy aging. Gerontologist 6(4):179–184. Bernstein E, Kim SY, Carmell MA, Murchison EP, Alcorn H, Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. Clin Cancer Li MZ, et al. 2003. Dicer is essential for mouse develop- Res 14(23):7956–7962. ment. Nat Genet 35(3):215–217. Hu Z, Chen J, Tian T, Zhou X, Gu H, Xu L, et al. 2008. Genetic Ren C, Park SK, Vokonas PS, Sparrow D, Wilker E, Baccarelli A, et al. 2010. Air pollution and homocysteine: more evidence that oxidative stress-related genes modify effects of par- ticulate air pollution. Epidemiology 21(2):198–206. Brewer AC, Shah AM. 2009. Redox signalling and miRNA func- variants of miRNA sequences and non-small cell lung Rich DQ, Schwartz J, Mittleman MA, Link M, Luttmann- tion in cardiomyocytes. J Mol Cell Cardiol 47(1):2–4. cancer survival. J Clin Invest 118(7):2600–2608. Brook RD. 2008. Cardiovascular effects of air pollution. Clin Sci Hu Z, Liang J, Wang Z, Tian T, Zhou X, Chen J, et al. 2009. Common genetic variants in pre-microRNAs were asso- ciated with increased risk of breast cancer in Chinese women. Hum Mutat 30(1):79–84. Gibson H, Catalano PJ, et al. 2005. Association of short- term ambient air pollution concentrations and ventricular arrhythmias. Am J Epidemiol 161(12):1123–1132. Rocha S. 2007. Gene regulation under low oxygen: holding your breath for transcription. Trends Biochem Sci 32(8):389–397. Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Izzotti A, Calin GA, Arrigo P, Steele VE, Croce CM, De Flora S. Wilker et al. (Lond) 115(6):175–187. Burt VL, Whelton P, Roccella EJ, Brown C, Cutler JA, Higgins M, et al. 1995. Prevalence of hypertension in the US adult pop- ulation. Results from the Third National Health and Nutrition Examination Survey, 1988–1991. Hypertension 25(3):305–313. Chahine T, Baccarelli A, Litonjua A, Wright RO, Suh H, Gold DR, et al. 2007. Particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohort. Environ Health Perspect 115:1617–1622. Mann M, et al. 2000. Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli. J Cell Biol 148(6):1177–1186. Chen JF, Murchison EP, Tang R, Callis TE, Tatsuguchi M, Deng Z, et al. 2008. Targeted deletion of dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci USA 105(6):2111–2116. Cheng Y, Ji R, Yue J, Yang J, Liu X, Chen H, et al. 2007. MicroRNAs are aberrantly expressed in hypertrophic heart: do they play a role in cardiac hypertrophy? Am J Pathol 170(6):1831–1840. da Costa Martins PA, Bourajjaj M, Gladka M, Kortland M, van Oort RJ, Pinto YM, et al. 2008. Conditional Dicer gene dele- tion in the postnatal myocardium provokes spontaneous cardiac remodeling. Circulation 118(15):1567–1576. Divakaran V, Mann DL. 2008. The emerging role of microRNAs in cardiac remodeling and heart failure. Circ Res 103(10):1072–1083. Esquela-Kerscher A, Slack FJ. 2006. Oncomirs—microRNAs with a role in cancer. Nat Rev Cancer 6(4):259–269. et al. 2009. Autonomic effects of controlled fine particulate exposure in young healthy adults: effect modification by ozone. Environ Health Perspect 117:1287–1292. Franklin SS, Lopez VA, Wong ND, Mitchell GF, Larson MG, Vasan RS, et al. 2009. Single versus combined blood pres- sure components and risk for cardiovascular disease: The Framingham Heart Study. Circulation 119(2):243–250. Gold DR, Litonjua A, Schwartz J, Lovett E, Larson A, Nearing B, Ibald-Mulli A, Stieber J, Wichmann HE, Koenig W, Peters A. Rojas-Bracho L, Suh HH, Koutrakis P. 2000. Relationships 2001. Effects of air pollution on blood pressure: a popula- tion-based approach. Am J Public Health 91(4):571–577. among personal, indoor, and outdoor fine and coarse particle concentrations for individuals with COPD. J Expo Ikeda S, Kong SW, Lu J, Bisping E, Zhang H, Allen PD, et al. Anal Environ Epidemiol 10(3):294–306. 2007. Altered microRNA expression in human heart dis- Schwartz J, Litonjua A, Suh H, Verrier M, Zanobetti A, Syring M, Luthra R, Singh RR, Luthra MG, Li YX, Hannah C, Romans AM, Urbich C, Kuehbacher A, Dimmeler S. 2008. Role of microRNAs ease. Physiol Genomics 31(3):367–373. 2009. Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke. FASEB J 23(3):806–812. Jansen KL, Larson TV, Koenig JQ, Mar TF, Fields C, Stewart J, et al. 2005. Associations between health effects and par- ticulate matter and black carbon in subjects with respira- tory disease. Environ Health Perspect 113:1741–1746. et al. 2008. MicroRNA-196a targets annexin A1: a microR- NA-mediated mechanism of annexin A1 downregulation in cancers. Oncogene 27(52):6667–6678. Madrigano J, Baccarelli A, Wright R, Suh H, Sparrow D, Vokonas P, et al. 2009. Air pollution, obesity, genes, and cellular adhesion molecules. Occup Environ Med; doi: 10.1136/oem.2009.046193 [Online 2 November 2009]. Madsen C, Nafstad P. 2006. Associations between environmen- tal exposure and blood pressure among participants in the Oslo Health Study (HUBRO). Eur J Epidemiol 21(7):485–491. Maniataki E, Mourelatos Z. 2005. A human, ATP-independent, et al. 2005. Traffic related pollution and heart rate variabil- ity in a panel of elderly subjects. Thorax 60(6):455–461. Suarez Y, Fernandez-Hernando C, Pober JS, Sessa WC. 2007. Dicer dependent microRNAs regulate gene expres- sion and functions in human endothelial cells. Circ Res 100(8):1164–1173. Suarez Y, Sessa WC. 2009. MicroRNAs as novel regulators of angiogenesis. Circ Res 104(4):442–454. 316(5824):575–579. in vascular diseases, inflammation, and angiogenesis. Cardiovasc Res 79(4):581–588. van Rooij E, Sutherland LB, Qi X, Richardson JA, Hill J, Olson EN. 2007. Control of stress-dependent cardiac growth and gene expression by a microRNA. Science Wan D, He M, Wang J, Qiu X, Zhou W, Luo Z, et al. 2004. Two variants of the human hepatocellular carcinoma-asso- ciated HCAP1 gene and their effect on the growth of the human liver cancer cell line Hep3B. Genes Chromosomes Cancer 39(1):48–58. RISC assembly machine fueled by pre-miRNA. Genes Dev Williams B, Lindholm LH, Sever P. 2008. Systolic pressure is all 19(24):2979–2990. that matters. Lancet 371(9631):2219–2221. Genet 15 Spec No 1:R17–R29. Maynard D, Coull BA, Gryparis A, Schwartz J. 2007. Mortality Evaluation of genetic variants in microRNA-related genes and risk of bladder cancer. Cancer Res 68(7):2530–2537. risk associated with short-term exposure to traffic par- Yang W, Paschen W. 2008. Conditional gene silencing in mam- ticles and sulfates. Environ Health Perspect 115:751–755. Mordukhovich I, Wilker EH, Suh H, Wright RO, Sparrow D, Vokonas PS, et al. 2009. Black carbon exposure, oxidative stress genes, and blood pressure in a repeated measures study. Environ Health Perspect 117:1767–1772. malian cells mediated by a stress-inducible promoter. Biochem Biophys Res Commun 365(3):521–527. Yang WJ, Yang DD, Na S, Sandusky GE, Zhang Q, Zhao G. 2005. Dicer is required for embryonic angiogenesis during mouse development. J Biol Chem 280(10):9330–9335. Fakhri AA, Ilic LM, Wellenius GA, Urch B, Silverman F, Gold DR, Mattick JS, Makunin IV. 2006. Non-coding RNA. Hum Mol Yang H, Dinney CP, Ye Y, Zhu Y, Grossman HB, Wu X. 2008. et al. 2000. Ambient pollution and heart rate variability. Murashov AK, Chintalgattu V, Islamov RR, Lever TE, Pak ES, Zanobetti A, Canner MJ, Stone PH, Schwartz J, Sher D, Eagan- Circulation 101(11):1267–1273. Griffiths-Jones S, Saini HK, van Dongen S, Enright AJ. 2008. Sierpinski PL, et al. 2007. RNAi pathway is functional in peripheral nerve axons. FASEB J 21(3):656–670. Bengston E, et al. 2004. Ambient pollution and blood pressure in cardiac rehabilitation patients. Circulation miRBase: Tools for microRNA genomics. Nucleic Acids O’Neill MS, Veves A, Zanobetti A, Sarnat JA, Gold DR, 110(15):2184–2189. Res 36(database issue):D154–D158. Han J, Lee Y, Yeom KH, Nam JW, Heo I, Rhee JK, et al. 2006. Molecular basis for the recognition of primary microRNAs by the drosha-DGCR8 complex. Cell 125(5):887–901. Economides PA, et al. 2005. Diabetes enhances vulner- ability to particulate air pollution-associated impairment in vascular reactivity and endothelial function. Circulation 111(22):2913–2920. Zeger SL, Thomas D, Dominici F, Samet JM, Schwartz J, Dockery D, et al. 2000. Exposure measurement error in time-series studies of air pollution: concepts and conse- quences. Environ Health Perspect 108:419–426. Harrabi I, Rondeau V, Dartigues JF, Tessier JF, Filleul L. 2006. Park SK, O’Neill MS, Wright RO, Hu H, Vokonas PS, Sparrow D, Zhang C. 2008. MicroRNAs: role in cardiovascular biology and Effects of particulate air pollution on systolic blood pressure: a population-based approach. Environ Res 101(1):89–93. et al. 2006. HFE genotype, particulate air pollution, and heart rate variability: a gene-environment interaction. Circulation 114(25):2798–2805. disease. Clin Sci (Lond) 114(12):699–706. 948 ovlume 118 | number 7 | July 2010 • Environmental Health Perspectives