27. Severe sepsis bundles. Resuscitation bundle. http://www.survivingsepsis. org/Bundles/Pages/default.aspx. Accessed 5 Dec 2009 28. Severe sepsis bundles. Management bundle. http://www.survivingsepsis. org/Bundles/Pages/default.aspx. Accessed 5 Dec 2009 29. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G; SCCM/ESICM/ACCP/ATS/SIS (2003) 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis deﬁnitions conference. Crit Care Med 31:1250–1256 30. Townsend S, Dellinger RP, Levy MM, Ramsay G (eds) (2005) Implementing the Surviving Sepsis Campaign. Society of Critical Care Medicine, Mount Prospect 31. http://www.hhs.gov/ohrp/qualityfaq. html. Accessed 12 Aug 2009 32. Pronovost P, Needham D, Berenholtz S, Sinopoli D, Chu H, Cosgrove S, Sexton B, Hyzy R, Welsh R, Roth G, Bander J, Kepros J, Goeschel C (2006) An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med 355:2725–2732 231 33. Shapiro NI, Howell MD, Talmor D, 36. Kumar A, Roberts D, Wood KE, Light Lahey D, Ngo L, Buras J, Wolfe RE, B, Parrillo JE, Sharma S, Suppes R, Weiss JW, Lisbon A (2006) Feinstein D, Zanotti S, Taiberg L, Implementation and outcomes of the Gurka D, Kumar A, Cheang M (2006) Multiple Urgent Sepsis Therapies Duration of hypotension before (MUST) protocol. Crit Care Med initiation of effective antimicrobial 34:1025–1032 therapy is the critical determinant of 34. El Solh AA, Akinnusi ME, Alsawalha survival in human septic shock. Crit LN, Pineda LA (2008) Outcome of Care Med 34:1589–1596 septic shock in older adults after 37. The NICE-SUGAR Study Investigators implementation of the sepsis ‘‘bundle’’. (2009) Intensive versus conventional J Am Geriatr Soc 56:272–278 glucose control in critically ill patients. 35. Nguyen HB, Corbett SW, Steele R, N Engl J Med 360:1283–1297 Banta J, Clark RT, Hayes SR, Edwards 38. Ferrer R, Artigas A, Levy MM, Blanco J, Cho TW, Wittlake WA (2007) J, Gonza´lez-D´ıaz G, Garnacho-Montero Implementation of a bundle of quality J, Iba´ n˜ez J, Palencia E, Quintana M, de indicators for the early management of la Torre-Prados MV, Edusepsis Study severe sepsis and septic shock is Group (2008) Improvement in process associated with decreased mortality. of care and outcome after a multicenter Crit Care Med 35:1105–1112 severe sepsis educational program in Spain. JAMA 299:2294–2303