D76 Nucleic Acids Research, 2008, Vol. 36, Database issue 40. Mello,C.C., Draper,B.W. and Priess,J.R. (1994) The maternal genes apx-1 and glp-1 and establishment of dorsal-ventral polarity in the early C. elegans embryo. Cell, 77, 95–106. 41. Zhong,W. and Sternberg,P.W. (2006) Genome-wide prediction of C. elegans genetic interactions. Science, 311, 1481–1484. 42. Lin,R., Thompson,S. and Priess,J.R. (1995) pop-1 encodes an HMG box protein required for the speciﬁcation of a mesoderm precursor in early C. elegans embryos. Cell, 83, 599–609. 43. Siegfried,K.R. and Kimble,J. (2002) POP-1 controls axis formation during early gonadogenesis in C. elegans. Development, 129, 443–453. 44. Lo,M.C., Gay,F., Odom,R., Shi,Y. and Lin,R. (2004) Phosphorylation by the beta-catenin/MAPK complex promotes 14-3-3-mediated nuclear export of TCF/POP-1 in signal-responsive cells in C. elegans. Cell, 117, 95–106. 45. Morton,D.G., Roos,J.M. and Kemphues,K.J. (1992) par-4, a gene required for cytoplasmic localization and determination of speciﬁc cell types in Caenorhabditis elegans embryogenesis. Genetics, 130, 771–790. 46. Watts,J.L., Etemad-Moghadam,B., Guo,S., Boyd,L., Draper,B.W., Mello,C.C., Priess,J.R. and Kemphues,K.J. (1996) par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3. Development, 122, 3133–3140. 47. Berkowitz,L.A. and Strome,S. (2000) MES-1, a protein required for unequal divisions of the germline in early C. elegans embryos, resembles receptor tyrosine kinases and is localized to the boundary between the germline and gut cells. Development, 127, 4419–4431. 48. Basham,S.E. and Rose,L.S. (1999) Mutations in ooc-5 and ooc-3 disrupt oocyte formation and the reestablishment of asymmetric PAR protein localization in two-cell Caenorhabditis elegans embryos. Dev. Biol., 215, 253–263. 49. Afshar,K., Willard,F.S., Colombo,K., Siderovski,D.P. and Gonczy,P. (2005) Cortical localization of the Galpha protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division. Development, 132, 4449–4459. 50. Lee,J.Y., Marston,D.J., Walston,T., Hardin,J., Halberstadt,A. and Goldstein,B. (2006) Wnt/Frizzled signaling controls C. elegans gastrulation by activating actomyosin contractility. Curr. Biol., 16, 1986–1997.