Neural Signatures of ACE Figure 3. N400-like effect for OHG and CHG. The channel locations of selected electrodes are shown in the grey circle. Note that the incompatible stimuli which elicits N400 amplitude enhancement are OHS in CHG (Figure 3.A) and CHS in the OHG (Figure 3.B). doi:10.1371/journal.pone.0011751.g003 verb, and the motor MRCPs were time-locked to the onset of the button activation. Our results revealed that in the semantics-to- motor direction: (a) cortical markers of motor process (MP and RAP) are affected by semantic effects, and in the motor-to- semantics direction; and (b) brain markers of comprehension processes (N400-like) are modulated by motor effects. Thus, both cortical processes of the task show modulation by their counterpart. Basically, language and action, both co-operators of the coupling, impact each other. Therefore, the bidirectionality hypothesis was supported. PLoS ONE | www.plosone.org 7 July 2010 | Volume 5 | Issue 7 | e11751