Lamin B1 and Neural Tube Defects 50. Moir RD, Spann TP, Herrmann H, Goldman RD (2000) Disruption of nuclear lamin organization blocks the elongation phase of DNA replication. J Cell Biol 149: 1179–1192. 51. Malhas AN, Lee CF, Vaux DJ (2009) Lamin B1 controls oxidative stress responses via Oct-1. J Cell Biol 184: 45–55. 52. Gong D, Pomerening JR, Myers JW, Gustavsson C, Jones JT, et al. (2007) Cyclin A2 regulates nuclear-envelope breakdown and the nuclear accumulation of cyclin B1. Curr Biol 17: 85–91. 53. Shimi T, Butin-Israeli V, Adam SA, Hamanaka RB, Goldman AE, et al. (2011) The role of nuclear lamin B1 in cell proliferation and senescence. Genes Dev 25: 2579–2593. 54. Seller MJ, Perkins KJ (1986) Effect of mitomycin C on the neural tube defects of the curly-tail mouse. Teratology 33: 305–309. 55. Greene ND, Bamidele A, Choy M, de Castro SC, Wait R, et al. (2007) Proteome changes associated with hippocampal MRI abnormalities in the lithium pilocarpine- induced model of convulsive status epilepticus. Proteomics 7: 1336–1344. 56. Greene NDE, Leung KY, Wait R, Begum S, Dunn MJ, et al. (2002) Differential protein expression at the stage of neural tube closure in the mouse embryo. J Biol Chem 277: 41645–41651. 57. Maske CP, Hollinshead MS, Higbee NC, Bergo MO, Young SG, et al. (2003) A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation. J Cell Biol 162: 1223–1232. PLOS Genetics | www.plosgenetics.org 14 November 2012 | Volume 8 | Issue 11 | e1003059