DRP-1b - A Novel ZIPk-Like Isoform Figure 1. The DAPk family of proteins and the new member, DRP-1b. A. The percentage in the blue boxes, representing the catalytic domain of the kinases, indicates the extent of identity of each catalytic domain to the kinase domain of DAPk. B. A scheme of the genomic locus of DRP-1, DRP-1b exon and the DRP-1b protein structure. Dark blue- catalytic domain coding exons; light blue- CaM binding domain encoding exons, pink- dimerization tail encoding exons; red and green- the alternative open reading frame. Percents indicate similarity of the catalytic or extra-catalytic domain to the indicated protein. Enlarged area shows sequence alignment of the human alternative exon and the extra catalytic domain of human ZIPk. Letters indicate identities, pluses indicate similarities. Gray background indicates a non aligned area. LZ- leucine zipper. C. DNA sequence at the 59 and 39 of human DRP-1b alternative exon. Red- open reading frame; Green- splicing acceptor site. Capital letters- translated amino acids. doi:10.1371/journal.pone.0017344.g001 PLoS ONE | www.plosone.org 2 February 2011 | Volume 6 | Issue 2 | e17344