10. deRegnier RA, Long JD, Georgieff MK, Nelson CA (2007) Using event-related potentials to study perinatal nutrition and brain development in infants of diabetic mothers. Dev Neuropsychol 31: 379–396. 11. Georgieff MK (2006) The effect of maternal diabetes during pregnancy on the neurodevelopment of offspring. Minn Med 89: 44–47. 12. Love AL, Billett HH (2008) Obesity, bariatric surgery, and iron deficiency: true, true, true and related. Am J Hematol 83: 403–409. 13. Xanthakos SA (2009) Nutritional deficiencies in obesity and after bariatric surgery. Pediatr Clin North Am 56: 1105–1121. 14. Banhidy F, Acs N, Puho EH, Czeizel AE (2010) Iron deficiency anemia: Pregnancy outcomes with or without iron supplementation. Nutrition. 15. El Guindi W, Pronost J, Carles G, Largeaud M, El Gareh N, et al. (2004) Severe maternal anemia and pregnancy outcome. J Gynecol Obstet Biol Reprod (Paris) 33: 506–509. 16. Lee HS, Kim MS, Kim MH, Kim YJ, Kim WY (2006) Iron status and its association with pregnancy outcome in Korean pregnant women. Eur J Clin Nutr 60: 1130–1135. 17. Scholl TO (2005) Iron status during pregnancy: setting the stage for mother and infant. Am J Clin Nutr 81: 1218S–1222S. 18. Singla PN, Tyagi M, Kumar A, Dash D, Shankar R (1997) Fetal growth in maternal anaemia. J Trop Pediatr 43: 89–92. 19. Beard J (2007) Recent evidence from human and animal studies regarding iron status and infant development. J Nutr 137: 524S–530S. 20. Beard JL, Connor JD, Jones BC (1993) Brain iron: location and function. Prog Food Nutr Sci 17: 183–221. 21. Beard JL, Hendricks MK, Perez EM, Murray-Kolb LE, Berg A, et al. (2005) Maternal iron deficiency anemia affects postpartum emotions and cognition. J Nutr 135: 267–272. 22. Corapci F, Radan AE, Lozoff B (2006) Iron deficiency in infancy and mother- child interaction at 5 years. J Dev Behav Pediatr 27: 371–378. 23. Eden AN (2005) Iron deficiency and impaired cognition in toddlers: an underestimated and undertreated problem. Paediatr Drugs 7: 347–352. 24. Grantham-McGregor S, Ani C (2001) A review of studies on the effect of iron deficiency on cognitive development in children. J Nutr 131: 649S–666S; discussion 666S-668S. 25. Halterman JS, Kaczorowski JM, Aligne CA, Auinger P, Szilagyi PG (2001) Iron deficiency and cognitive achievement among school-aged children and adolescents in the United States. Pediatrics 107: 1381–1386. 26. Lozoff B (1989) Iron and learning potential in childhood. Bull N Y Acad Med 65: 1050–1066; discussion 1085-1058. 27. Lozoff B (2000) Perinatal iron deficiency and the developing brain. Pediatr Res 48: 137–139. 28. Lozoff B, Beard J, Connor J, Barbara F, Georgieff M, et al. (2006) Long-lasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev 64: S34–43; discussion S72-91. 29. Lozoff B, Brittenham GM (1986) Behavioral aspects of iron deficiency. Prog Hematol 14: 23–53. 30. Lozoff B, Brittenham GM (1987) Behavioral alterations in iron deficiency. Hematol Oncol Clin North Am 1: 449–464. 31. Lozoff B, Brittenham GM, Wolf AW, McClish DK, Kuhnert PM, et al. (1987) Iron deficiency anemia and iron therapy effects on infant developmental test performance. Pediatrics 79: 981–995. 32. Lozoff B, Clark KM, Jing Y, Armony-Sivan R, Angelilli ML, et al. (2008) Dose- response relationships between iron deficiency with or without anemia and infant social-emotional behavior. J Pediatr 152: 696–702, 702 631-693. 33. Lukowski AF, Koss M, Burden MJ, Jonides J, Nelson CA, et al. (2010) Iron deficiency in infancy and neurocognitive functioning at 19 years: evidence of long-term deficits in executive function and recognition memory. Nutr Neurosci 13: 54–70. 34. Wachs TD, Pollitt E, Cueto S, Jacoby E, Creed-Kanashiro H (2005) Relation of neonatal iron status to individual variability in neonatal temperament. Dev Psychobiol 46: 141–153. 35. Walter T (1994) Effect of iron-deficiency anaemia on cognitive skills in infancy and childhood. Baillieres Clin Haematol 7: 815–827. 36. Brigham D, Beard J (1996) Iron and thermoregulation: a review. Crit Rev Food Sci Nutr 36: 747–763. 37. Ece A, Yigitoglu MR, Vurgun N, Guven H, Iscan A (1999) Serum lipid and lipoprotein profile in children with iron deficiency anemia. Pediatr Int 41: 168–173. 38. Hartfield DS, Lowry NJ, Keene DL, Yager JY (1997) Iron deficiency: a cause of stroke in infants and children. Pediatr Neurol 16: 50–53. 39. Hartfield DS, Tan J, Yager JY, Rosychuk RJ, Spady D, et al. (2009) The association between iron deficiency and febrile seizures in childhood. Clin Pediatr (Phila) 48: 420–426. 40. Angulo-Kinzler RM, Peirano P, Lin E, Algarin C, Garrido M, et al. (2002) Twenty-four-hour motor activity in human infants with and without iron deficiency anemia. Early Hum Dev 70: 85–101. 41. Angulo-Kinzler RM, Peirano P, Lin E, Garrido M, Lozoff B (2002) Spontaneous motor activity in human infants with iron-deficiency anemia. Early Hum Dev 66: 67–79. 42. Shafir T, Angulo-Barroso R, Jing Y, Angelilli ML, Jacobson SW, et al. (2008) Iron deficiency and infant motor development. Early Hum Dev 84: 479–485. Impact of Maternal Iron Restriction on Offspring 43. Algarin C, Peirano P, Garrido M, Pizarro F, Lozoff B (2003) Iron deficiency anemia in infancy: long-lasting effects on auditory and visual system functioning. Pediatr Res 53: 217–223. 44. Amin SB, Orlando M, Eddins A, MacDonald M, Monczynski C, et al. (2009) In utero iron status and auditory neural maturation in premature infants as evaluated by auditory brainstem response. J Pediatr 156: 377–381. 45. Cankaya H, Oner AF, Egeli E, Caksen H, Uner A, et al. (2003) Auditory brainstem response in children with iron deficiency anemia. Acta Paediatr Taiwan 44: 21–24. 46. Lozoff B, De Andraca I, Castillo M, Smith JB, Walter T, et al. (2003) Behavioral and developmental effects of preventing iron-deficiency anemia in healthy full-term infants. Pediatrics 112: 846–854. 47. De Pee S, Bloem MW, Sari M, Kiess L, Yip R, et al. (2002) The high prevalence of low hemoglobin concentration among Indonesian infants aged 3- 5 months is related to maternal anemia. J Nutr 132: 2215–2221. 48. Emamghorashi F, Heidari T (2004) Iron status of babies born to iron-deficient anaemic mothers in an Iranian hospital. East Mediterr Health J 10: 808–814. 49. Georgieff MK, Wewerka SW, Nelson CA, Deregnier RA (2002) Iron status at 9 months of infants with low iron stores at birth. J Pediatr 141: 405–409. 50. Fairbanks VF (1994) Blue gods, blue oil, and blue people. Mayo Clin Proc 69: 889–892. 51. Florentino RF, Villavieja GM, Boquecosa JP, Bacos FF (1992) Nutrition situation in metro Manila. Southeast Asian J Trop Med Public Health 23(Suppl 3): 31–45. 52. Looker AC, Dallman PR, Carroll MD, Gunter EW, Johnson CL (1997) Prevalence of iron deficiency in the United States. Jama 277: 973–976. 53. Morath DJ, Mayer-Proschel M (2002) Iron deficiency during embryogenesis and consequences for oligodendrocyte generation in vivo. Dev Neurosci 24: 197–207. 54. Cutmore TR (2004) The use of wavelets for auditory brain-stem analysis: advocacy and precautions. Clin Neurophysiol 115: 998–1000. 55. Hall JW, 3rd, Rupp KA (1997) Auditory brainstem response: recent developments in recording and analysis. Adv Otorhinolaryngol 53: 21–45. 56. Legatt AD (2002) Mechanisms of intraoperative brainstem auditory evoked potential changes. J Clin Neurophysiol 19: 396–408. 57. Shaw (1995) The temporal relationship between the brainstem and primary cortical auditory evoked potentials. Prog Neurobiol 47: 95–103. 58. Ito T, Tokuriki M, Shibamori Y, Saito T, Nojyo Y (2004) Cochlear nerve demyelination causes prolongation of wave I latency in ABR of the myelin deficient (md) rat. Hear Res 191: 119–124. 59. Knipper M, Bandtlow C, Gestwa L, Kopschall I, Rohbock K, et al. (1998) Thyroid hormone affects Schwann cell and oligodendrocyte gene expression at the glial transition zone of the VIIIth nerve prior to cochlea function. Development 125: 3709–3718. 60. Church MW, Jen KL, Jackson DA, Adams BR, Hotra JW (2009) Abnormal neurological responses in young adult offspring caused by excess omega-3 fatty acid (fish oil) consumption by the mother during pregnancy and lactation. Neurotoxicol Teratol 31: 26–33. 61. Noben-Trauth K, Latoche JR, Neely HR, Bennett B (2010) Phenotype and genetics of progressive sensorineural hearing loss (Snhl1) in the LXS set of recombinant inbred strains of mice. PLoS One 5: e11459. 62. Ponton CW, Moore JK, Eggermont JJ (1996) Auditory brain stem response generation by parallel pathways: differential maturation of axonal conduction time and synaptic transmission. Ear Hear 17: 402–410. 63. Wang Y, Manis PB (2005) Synaptic transmission at the cochlear nucleus endbulb synapse during age-related hearing loss in mice. J Neurophysiol 94: 1814–1824. 64. Maison SF, Casanova E, Holstein GR, Bettler B, Liberman MC (2009) Loss of GABAB receptors in cochlear neurons: threshold elevation suggests modulation of outer hair cell function by type II afferent fibers. J Assoc Res Otolaryngol 10: 50–63. 65. Park HJ, Kim HJ, Bae GS, Seo SW, Kim DY, et al. (2009) Selective GSK- 3beta inhibitors attenuate the cisplatin-induced cytotoxicity of auditory cells. Hear Res 257: 53–62. 66. Tanaka C, Chen GD, Hu BH, Chi LH, Li M, et al. (2009) The effects of acoustic environment after traumatic noise exposure on hearing and outer hair cells. Hear Res 250: 10–18. 67. Wu HP, Hsu CJ, Cheng TJ, Guo YL (2010) N-acetylcysteine attenuates noise- induced permanent hearing loss in diabetic rats. Hear Res 267: 71–77. 68. Chong WS, Kwan PC, Chan LY, Chiu PY, Cheung TK, et al. (2005) Expression of divalent metal transporter 1 (DMT1) isoforms in first trimester human placenta and embryonic tissues. Hum Reprod 20: 3532–3538. 69. Dallman PR (1986) Iron deficiency in the weanling: a nutritional problem on the way to resolution. Acta Paediatr Scand Suppl 323: 59–67. 70. Gambling L, Danzeisen R, Gair S, Lea RG, Charania Z, et al. (2001) Effect of iron deficiency on placental transfer of iron and expression of iron transport proteins in vivo and in vitro. Biochem J 356: 883–889. 71. Munoz C, Olivares M, Schlesinger L, Lopez M, Letelier A (1994) Increased in vitro tumour necrosis factor-alpha production in iron deficiency anemia. Eur Cytokine Netw 5: 401–404. 72. Jaime-Perez JC, Herrera-Garza JL, Gomez-Almaguer D (2005) Sub-optimal fetal iron acquisition under a maternal environment. Arch Med Res 36: 598–602. PLoS ONE | www.plosone.org 12 March 2011 | Volume 6 | Issue 3 | e17483