The PA System Modulates ESC Differentiation 30. Dani C, Smith AG, Dessolin S, Leroy P, Staccini L, et al. (1997) Differentiation of embryonic stem cells into adipocytes in vitro. J Cell Sci 110: 1279–1285. 31. Aouadi M, Laurent K, Prot M, Le Marchand-Brustel Y, Binetruy B, et al. (2006) Inhibition of p38MAPK Increases Adipogenesis From Embryonic to Adult Stages10.2337/diabetes.55.02.06.db05–0963. Diabetes 55: 281–289. 32. Vassalli J-D, Belin D (1987) Amiloride selectively inhibits the urokinase-type plasminogen activator. FEBS letters 214: 187–191. 33. Ishida T, Tsukada H, Hasegawa T, Yoshizawa H, Gejyo F (2006) Matrix Metalloproteinase-1 Activation via Plasmin Generated on Alveolar Epithelial Cell Surfaces. Lung 184: 15–19. 34. Binder BR, Mihaly J, Prager GW (2007) uPAR-uPA-PAI-1 interactions and signaling: a vascular biologist’s view. Thromb Haemost 97: 336–342. 35. Lopez-Alemany R, Redondo JM, Nagamine Y, Munoz-Canoves P (2003) Plasminogen activator inhibitor type-1 inhibits insulin signaling by competing with &#x03B1;v&#x03B2;3 integrin for vitronectin binding. European Journal of Biochemistry 270: 814–821. 36. Kennedy K, Porter T, Mehta V, Ryan S, Price F, et al. (2009) Retinoic acid enhances skeletal muscle progenitor formation and bypasses inhibition by bone morphogenetic protein 4 but not dominant negative beta-catenin. BMC Biology 7: 67. PLOS ONE | www.plosone.org 15 November 2012 | Volume 7 | Issue 11 | e49065