HLA, HCP5 and ZNRD1 in HIV Figure 2. Disease-influencing effects associated with HLA-A10/ZNRD1-containing genotypes. (A) Plots are Kaplan-Meier curves for time to AIDS (1987 criteria). Disease-influencing effects of the ZNRD1 SNP in all subjects (left column), and in the European American (middle column) and African American (right column) components of the WHMC cohort. (B) Kaplan-Meier plots depicting the influence on rate of disease progression of alleles categorized into the HLA-A10 serogroup. The relative hazards (RH) and 95% confidence intervals (CI) were computed before (values above the complete horizontal line) and after (values below the complete horizontal line) adjustment for ethnic background, cohort membership across different therapy eras, CCL3L1-CCR5 genetic risk group status and whether date of seroconversion was known. (C) Six genotypic groups (enumerated, color-coded) were derived by accounting for HLA-A10 status and the ZNRD1 genotype. Number of subjects in each genotypic group are shown within the color-coded boxes. (D) Kaplan-Meier plot for the disease-influencing effects of the six genotypic groups (Gp) shown in panel C. RH, CI, and significance values are depicted to the right and were obtained by Cox proportional hazards modeling. n, number of subjects. Group 1 (Lacking HLA- PLoS ONE | www.plosone.org 5 November 2008 | Volume 3 | Issue 11 | e3636