Gelsolin Induces Cancer Invasion via uPA Cascade Figure 1. Gelsolin immunohistochemistry in human colorectal carcinoma tissues. Gelsolin is heterogeneously expressed in a number of primary tumors (A) and liver metastases (B), with islands of low (arrowed in blue) and high (arrowed in red) expression observed within a tumor. Gelsolin expression is mainly cytoplasmic but occasionally, nuclear (C) and perinuclear (D) staining are detected (arrowed). Gelsolin is strongly expressed in a mucinous adenocarcinoma (E) and in stroma (A, B). doi:10.1371/journal.pone.0043594.g001 PLOS ONE | www.plosone.org 3 August 2012 | Volume 7 | Issue 8 | e43594