Inhibition of SEB Intoxication by a MyD88 Mimetic Figure 8. EM-163 attenuates SEB -induced pro-inflammatory serum cytokines and lethality in mice. BALB/c mice (n = 6) were injected (i.p.) with different amounts of EM-163, 30 min later injected with SEB followed by LPS 2 h later. Mice were observed to determine if mice survived, or time to death if they did not. Control mice injected only with 60 mg of LPS or 1 mg of SEB survived. Data represent three separate experiments. Kaplan PLoS ONE | www.plosone.org 10 July 2012 | Volume 7 | Issue 7 | e40773