Karyotypic Determinants of Chromosome Instability Figure 3. Correlations between CIN and growth rate, total genome content, or degree of aneuploidy across the aneuploid strains. (A–C and E–F) Normalized density distribution of the growth rate (A), calculated ploidy (B), total number of chromosomes in the genome (C), total number of chromosomes in aneuploidy (E), and total number of the megabases in aneuploidy (F) in the aneuploid strains in the three CIN classes. Density distribution functions were fitted on the data based on a Gaussian kernel and normalized to a maximum density of 1. The area of the three underlying curves was scaled to the relative proportion of strains in each category. (D) Distribution of the aneuploid strains based on basal ploidy. Green: S strains; blue: MU strains; red: HU strains. P-values at the top of each graph refer to the difference in means between the S and HU strains by using a Welch’s t-test. doi:10.1371/journal.pgen.1002719.g003 PLoS Genetics | www.plosgenetics.org 7 May 2012 | Volume 8 | Issue 5 | e1002719