SLC11A1 Polymorphisms and TB Figure 3. Meta-analysis of the association between tuberculosis and SLC11A1 D543N polymorphism (*A vs. GG). a = subgroup of patients with spinal tuberculosis; b = subgroup of patients with pulmonary tuberculosis; c = subgroup of patients who were aboriginal Taiwanese; d = subgroup of patients who were Hans; CI = confidence interval; OR = odds ratio. doi:10.1371/journal.pone.0015831.g003 Discussion This review addressed the associations between SLC11A1 poly- morphisms and TB susceptibility reported until September 2010. Thirty six articles addressing the most widely studied SLC11A1 polymorphisms (39 UTR, D543N, INT4 and 59 (GT)n) were identified, and their effects were summarized by means of meta- analysis. Significant associations with TB susceptibility were observed for all these four loci. Strength of the associations in the subgroup analyses with respect to study population was not consistent. However, significant association has been observed for all populations (Africans, Asians and Westerns) with at least one of the four loci. Limited PLoS ONE | www.plosone.org 4 January 2011 | Volume 6 | Issue 1 | e15831