KDM2B Mutation in Cattle Figure 2. Genome-wide association and homozygosity mapping of the paunch calf syndrome locus. (A) Case-control genome-wide association analysis shows a significant association to SNPs on BTA 17. (B) Single SNP association results across BTA 17. (C) The limit of the homozygous 1.23 Mb interval shared by the 16 cases is highlighted in red. (D) Gene content of the corresponding human chromosome 5 segments. The KDM2B gene containing the causative mutation is highlighted in red. doi:10.1371/journal.pone.0045634.g002 PLOS ONE | www.plosone.org 4 September 2012 | Volume 7 | Issue 9 | e45634