56. Moreno-Romero J, Espunya MC, Platara M, Arin˜o J, Mart´ınez MC (2008) A role for protein kinase CK2 in plant development: evidence obtained using a dominant-negative mutant. Plant J 55: 118–130. 57. Bretner M, Najda-Bernatowicz A, Łebska M, Muszyn´ ska G, Kilanowicz A, et al. (2008) New inhibitors of protein kinase CK2, analogues of benzimidazole and benzotriazole. Mol Cell Biochem 316: 87–89. 58. Locke JC, Kozma-Bognar L, Gould PD, Feher B, Kevei E, et al. (2006) Experimental validation of a predicted feedback loop in the multi-oscillator clock of Arabidopsis thaliana. Mol Syst Biol 2: 59. 59. Ding Z, Doyle MR, Amasino RM, Davis SJ (2007) A complex genetic interaction between Arabidopsis thaliana TOC1 and CCA1/LHY in driving the circadian clock and in output regulation. Genetics 176: 1501–1510. 60. Millar AJ, Kay SA (1996) Integration of circadian and phototransduction pathways in the network controlling CAB gene transcription in Arabidopsis. Proc Natl Acad Sci USA 93: 15491–15496. 61. Mizoguchi T, Wheatley K, Hanzawa Y, Wright L, Mizoguchi M, et al. (2002) LHY and CCA1 are partially redundant genes required to maintain circadian rhythms in Arabidopsis. Dev Cell 2: 629–641. 62. Schafmeier T, Haase A, Ka´ldi K, Scholz J, Fuchs M, et al. (2005) Transcriptional Feedback of Neurospora Circadian Clock Gene by Phosphor- ylation-Dependent Inactivation of Its Transcription Factor. Cell 122: 235–246. 63. Liu C-C, Richard AJ, Datta K, LiCata VJ (2008) Prevalence of Temperature- Dependent Heat Capacity Changes in Protein-DNA Interactions. Biophysical Journal 94: 3258–3265. Clock Temperature Compensation in Arabidopsis 64. Bibby AC, Litchfield DW (2005) The multiple personalities of the regulatory subunit of protein kinase CK2: CK2 dependent and CK2 independent roles reveal a secret identity for CK2ß. Int J Biol Sci 1: 67–79. 65. Hardtke CS, Gohda K, Osterlund MT, Oyama T, Okada K, et al. (2000) HY5 stability and activity in Arabidopsis is regulated by phosphorylation in its COP1 binding domain. EMBO J 19: 4997–5006. 66. Rensing L, Ruoff P (2002) Temperature effect on entrainment, phase shifting, and amplitude of circadian clocks and its molecular bases. Chronobiol Int 19: 807–864. 67. Hong CI, Conrad ED, Tyson JJ (2007) A proposal for robust temperature compensation of circadian rhythms. Proc Natl Acad Sci USA 104: 1195–1200. 68. Isojima Y, Nakajima M, Ukai H, Fujishima H, Yamada RG, et al. (2009) CKIepsilon/delta-dependent-phosphorylation is a temperature-insensitive, pe- riod-determining process in the mammalian circadian clock. Proc Natl Acad Sci USA 106: 15744–15749. 69. Ma´s P, Kim WJ, Somers DE, Kay SA (2003) Targeted degradation of TOC1 by ZTL modulates circadian function in Arabidopsis. Nature 426: 567–570. 70. Xie Z, Grotewold E (2008) Serial ChIP as a tool to investigate the co-localization or exclusion of proteins on plant genes. Plant Methods 4: 25. 71. Millar AJ, Straume M, Chory J, Chua NH, Kay SA (1995) The regulation of circadian period by phototransduction pathways in Arabidopsis. Science 267: 1163–1166. PLoS Genetics | www.plosgenetics.org 15 November 2010 | Volume 6 | Issue 11 | e1001201