5. Liu L, Darnall L, Hu T, Choi K, Lane TE, et al. (2010) Myelin repair is accelerated by inactivating CXCR2 on nonhematopoietic cells. J Neurosci 30: 9074–83. 6. Gordon D, Pavlovska G, Uney JB, Wraith DC, Scolding NJ (2010) Human mesenchymal stem cells infiltrate the spinal cord, reduce demyelination, and localize to white matter lesions in experimental autoimmune encephalomyelitis. J Neuropathol Exp Neurol 69: 1087–95. 7. Kanwar JR, Kanwar RK, Krissansen GW (2004) Simultaneous neuroprotection and blockade of inflammation reverses autoimmune encephalomyelitis. Brain 127: 1313–31. 8. Makar TK, Trisler D, Bever CT, Goolsby JE, Sura KT, et al. (2008) Stem cell based delivery of IFN-beta reduces relapses in experimental autoimmune encephalomyelitis. J Neuroimmunol 196: 67–81. 9. Constantin G, Marconi S, Rossi B, Angiari S, Calderan L, et al. (2009) Adipose- derived mesenchymal stem cells ameliorate chronic experimental autoimmune encephalomyelitis. Stem Cells 27: 2624–35. 10. Aharoni R, Herschkovitz A, Eilam R (2008) Demyelination arrest and remyelination induced by glatiramer acetate treatment of experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 105: 11358–63. 11. Trapp BD, Nave KA (2008) Multiple sclerosis: an immune or neurodegenerative disorder? Annu Rev Neurosci 31: 247–69. 12. Wei Z, Mousseau DD, Richardson JS, Dyck LE, Li XM (2008) Atypical antipsychotics attenuate neurotoxicity of beta-amyloid(25–35) by modulating Bax and Bcl-X(l/s) expression and localization. J Neurosci Res 74: 942–7. 13. Kerns D, Vong GS, Barley K, Dracheva S, Katsel P, et al. (2010) Gene expression abnormalities and oligodendrocyte deficits in the internal capsule in schizophrenia. Schizophr Res 120: 150–8. 14. Xiao L, Xu H, Zhang Y, Wei Z, He J, et al. (2008) Quetiapine facilitates oligodendrocyte development and prevents mice from myelin breakdown and behavioral changes. Mol Psychiatry 13: 697–708. 15. Xu H, Wang H, Zhuang L, Yan B, Yu Y, et al. (2008) Demonstration of an anti- oxidative stress mechanism of quetiapine: implications for the treatment of Alzheimer’s disease. FEBS J 275: 3718–28. 16. Zhang Y, Xu H, Jiang W, Xiao L, Yan B, et al. (2008) Quetiapine alleviates the cuprizone-induced white matter pathology in the brain of C57BL/6 mouse. Schizophr Res 106: 182–91. 17. Bian Q, Kato T, Monji A, Hashioka S, Mizoguchi Y, et al. (2008) The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon-gamma. Prog Neuropsychopharmacol Biol Psychiatry 32: 42–8. 18. Stromnes IM, Goverman JM (2006) Active induction of experimental allergic encephalomyelitis. Nat Protoc 1: 1810–9. 19. Rasmussen S, Imitola J, Ayuso-Sacido A, Wang Y, Starossom SC, et al. (2011) Reversible neural stem cell niche dysfunction in a model of multiple sclerosis. Ann Neurol 69: 878–91. 20. Kuhlmann T, Miron V, Cui Q, Wegner C, Antel J, et al. (2008) Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis. Brain 131: 1749–58. Que Inhibits T Cell Proliferation 21. Franco PG, Silvestroff L, Soto EF, Pasquini JM (2008) Thyroid hormones promote differentiation of oligodendrocyte progenitor cells and improve remyelination after cuprizone-induced demyelination. Exp Neurol 212: 458–67. 22. Mason JL, Ye P, Suzuki K, D’Ercole AJ, Matsushima GK (2000) Insulin-like growth factor-1 inhibits mature oligodendrocyte apoptosis during primary demyelination. J Neurosci 20: 5703–8. 23. De SP, Axtell RC, Raman C, Roth KA, Alessi DR, et al (2008) Lithium prevents and ameliorates experimental autoimmune encephalomyelitis. J Immunol 181: 338–45. 24. Chang JF, Thomas CA III, Kung JT (1991) Mitogen-induced IL-2 production and proliferation at defined stages of T helper cell development. J Immunol 147: 860–6. 25. Maruo S, Toyo-oka K, Oh-hora M, Tai XG, Iwata H, et al. (1996) IL-12 produced by antigen-presenting cells induces IL-2-independent proliferation of T helper cell clones. J Immunol 156: 1748–55. 26. Inoue M, Okazaki T, Kitazono T, Mizushima M, Omata M, et al. (2011) Regulation of antigen-specific CTL and Th1 cell activation through 5- Hydroxytryptamine 2A receptor. Int Immunopharmacol 11: 67–73. 27. Freire-Garabal M, Nunez MJ, Balboa J, Garcia-Vallejo LA, Argibay S, et al. (2003) Administration of the 5-hydroxytryptamine(1A) receptor antagonist WAY100635 suppresses acute experimental allergic encephalomyelitis in Lewis rats. Neurosci Lett342: 33–6. 28. Nakane H, Sonobe Y, Watanabe T, Nakano K (2004) Histamine its novel role as an endogenous regulator of Con A-dependent T cell proliferation. Inflamm Res 53: 324–8. 29. Noubade R, Milligan G, Zachary JF, Blankenhorn EP, del Rio R, et al. (2007) Histamine receptor H1 is required for TCR-mediated p38 MAPK activation and optimal IFN-gamma production in mice. J Clin Invest 117: 3507–18. 30. Jones HM, Travis MJ, Mulligan R, D Visvikis, S Gacinovic, et al. (2000) In vivo serotonin 5-HT(2A) receptor occupancy and quetiapine. Am J Psychiatry 157: 148. 31. Ray LA, Heydari A, Zorick T (2010) Quetiapine for the treatment of alcoholism: scientific rationale and review of the literature. Drug Alcohol Rev 29: 568–75. 32. Janardhan V, Bakshi R (2002) Quality of life in patients with multiple sclerosis: the impact of fatigue and depression. J Neurol Sci 205: 51–8. 33. Mostert JP, Admiraal-Behloul F, Hoogduin JM, Luyendijk J, Heersema DJ, et al. (2008) Effects of fluoxetine on disease activity in relapsing multiple sclerosis: a double-blind, placebo-controlled, exploratory study. J Neurol Neurosurg Psychiatry 79: 1027–31. 34. Kerns D, Vong GS, Barley K, Dracheva S, Katsel P, et al. (2010) Gene expression abnormalities and oligodendrocyte deficits in the internal capsule in schizophrenia. Schizophr Res 120: 150–8. 35. Aston C, Jiang L, Sokolov BP (2005) Transcriptional profiling reveals evidence for signaling and oligodendroglial abnormalities in the temporal cortex from patients with major depressive disorder. Mol Psychiatry 10: 309–22. 36. Konradi C, Sillivan SE, Clay HB (2012) Mitochondria, oligodendrocytes and inflammation in bipolar disorder: evidence from transcriptome studies points to intriguing parallels with multiple sclerosis. Neurobiol Dis 45: 37–47. PLOS ONE | www.plosone.org 10 August 2012 | Volume 7 | Issue 8 | e42746