34. Pang L, Nie M, Corbett L, Knox AJ (2003) Cyclooxygenase-2 expression by nonsteroidal anti-inflammatory drugs in human airway smooth muscle cells: role of peroxisome proliferator-activated receptors. J Immunol 170: 1043–1051. 35. Fujimoto M, Nakai A (2010) The heat shock factor family and adaptation to proteotoxic stress. FEBS J 277: 4112–4125. 36. Zhao YH, Zhou M, Liu H, Ding Y, Khong HT, et al. (2009) Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth. Oncogene 28: 3689–3701. 37. Heintzman ND, Hon GC, Hawkins RD, Kheradpour P, Stark A, et al. (2009) Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature 459: 108–112. 38. Robertson AG, Bilenky M, Tam A, Zhao Y, Zeng T, et al. (2008) Genome-wide relationship between histone H3 lysine 4 mono- and tri-methylation and transcription factor binding. Genome Res 18: 1906–1917. 39. Guertin MJ, Lis JT (2010) Chromatin landscape dictates HSF binding to target DNA elements. PLoS Genet 6. 40. Sakurai H, Enoki Y (2010) Novel aspects of heat shock factors: DNA recognition, chromatin modulation and gene expression. FEBS J 277: 4140–4149. 41. Calderwood SK, Bornstein B, Farnum EK, Stevenson MA (1989) Heat shock stimulates the release of arachidonic acid and the synthesis of prostaglandins and leukotriene B4 in mammalian cells. J Cell Physiol 141: 325–333. 42. Arnaud C, Joyeux-Faure M, Godin-Ribuot D, Ribuot C (2003) COX-2: an in vivo evidence of its participation in heat stress-induced myocardial precondi- tioning. Cardiovasc Res 58: 582–588. 43. Hill JM, Lukiw WJ, Gebhardt BM, Higaki S, Loutsch JM, et al. (2001) Gene expression analyzed by microarrays in HSV-1 latent mouse trigeminal ganglion following heat stress. Virus Genes 23: 273–280. 44. Evers LH, Bhavsar D, Mailander P (2010) The biology of burn injury. Exp Dermatol 19: 777–783. 45. Rao W, Deng ZS, Liu J (2010) A review of hyperthermia combined with radiotherapy/chemotherapy on malignant tumors. Crit Rev Biomed Eng 38: 101–116. HSF1-Dependent COX-2 Induction by Heat 46. Jia D, Liu J (2010) Current devices for high-performance whole-body hyperthermia therapy. Expert Rev Med Devices 7: 407–423. 47. Blatteis CM, Li S, Li Z, Feleder C, Perlik V (2005) Cytokines, PGE2 and endotoxic fever: a re-assessment. Prostaglandins Other Lipid Mediat 76: 1–18. 48. Shinkawa T, Tan K, Fujimoto M, Hayashida N, Yamamoto K, et al. (2011) Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregation. Mol Biol Cell 22: 3571–3583. 49. Jaattela M (1999) Heat shock proteins as cellular lifeguards. Ann Med 31: 261–271. 50. Parsell DA, Lindquist S (1993) The function of heat-shock proteins in stress tolerance: degradation and reactivation of damaged proteins. Annu Rev Genet 27: 437–496. 51. Dobson CM (2003) Protein folding and misfolding. Nature 426: 884–890. 52. Xie Y, Chen C, Stevenson MA, Auron PE, Calderwood SK (2002) Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6. J Biol Chem 277: 11802–11810. 53. Inouye S, Fujimoto M, Nakamura T, Takaki E, Hayashida N, et al. (2007) Heat shock transcription factor 1 opens chromatin structure of interleukin-6 promoter to facilitate binding of an activator or a repressor. J Biol Chem 282: 33210–33217. 54. Singh IS, Gupta A, Nagarsekar A, Cooper Z, Manka C, et al. (2008) Heat shock co-activates interleukin-8 transcription. Am J Respir Cell Mol Biol 39: 235–242. 55. Rossi A, Ciafre S, Balsamo M, Pierimarchi P, Santoro MG (2006) Targeting the heat shock factor 1 by RNA interference: a potent tool to enhance hyperthermochemotherapy efficacy in cervical cancer. Cancer Res 66: 7678–7685. 56. Rossi A, Elia G, Santoro MG (1997) Inhibition of nuclear factor kappa B by prostaglandin A1: an effect associated with heat shock transcription factor activation. Proc Natl Acad Sci U S A 94: 746–750. 57. Rossi A, Kapahi P, Natoli G, Takahashi T, Chen Y, et al. (2000) Anti- inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature 403: 103–108. PLoS ONE | www.plosone.org 13 February 2012 | Volume 7 | Issue 2 | e31304