The LARGE Principle in AFiPSCs Figure 5. Expression of senescence-associated genes in primary AFCs and AFiPSCs. Heatmap depicting significantly differentially expressed senescence-associated genes in the union of AFiPSCs at approximately passage 20 compared to primary AFCs at passage 17 (AFC P17) (cut off: fold change $1.5 or #0.667 and FDR-adjusted P-Values for differential expression ,0.05). The heatmap is colored by LOG2 average expression signals according to the color key on the bottom. Genes and samples were clustered by similar expression patterns using Eucledian distance measure. doi:10.1371/journal.pone.0013703.g005 PLoS ONE | www.plosone.org 9 October 2010 | Volume 5 | Issue 10 | e13703