Sensory and Insulin-Like Signals Suppress Seizures Figure 5. Phospholipase C-gamma (PLC-3) is required for food-deprivation suppression of unc-103(0)-induced muscle seizures. (A) Graph displaying the effects of PLC-3, PLC-2 RNAi, and plc-3(sy698) on unc-103(0)-seizure susceptibility on food and no-food conditions. p-value for PLC-3 RNAi relative to unc-103(0) Mock RNAi no-food control, p-value for unc-103(0); plc-3(sy698) relative to unc-103(0) no-food control (Fisher’s exact test). (B) Pplc-3:YFP expression pattern in young adult male. The ventral protractors are labeled. Scale bar 6 mm. (C) Cartoon displaying the relevant structures in the head and male tail. (D) Proposed model for sensory regulation of sex-muscle excitability during food-deprivation. When food odors PLoS Genetics | www.plosgenetics.org 11 July 2008 | Volume 4 | Issue 7 | e1000117