Cardiovascular Collapse/Methamphetamine Fatality Figure 7. Methamphetamine induced mitochondrial dysfunction in RVLM. Fold changes relative to sham-control group in the activity of Complex I (A), II (B), III (C), IV (D) or V (E) and electron transfer capacity between Complexes I and III (NCCR; F)or II and III (SCCR; G) in the mitochondrial respiratory chain in samples collected from RVLM of rats died of METH (24 mg/kg, i.v.) or survived with pretreatment by microinjection of Mito- TEMPO (500 pmol) or coenzyme Q10 (CoQ10; 7 nmol) into bilateral RVLM prior to METH administration. Values are mean 6 SEM, n = 4–5 animals per experimental group. *P,0.05 versus Vehicle+Saline group, and #P,0.05 versus Vehicle+METH group in the post hoc Scheff e´ multiple-range test. doi:10.1371/journal.pone.0030589.g007 PLoS ONE | www.plosone.org 10 January 2012 | Volume 7 | Issue 1 | e30589