Que Inhibits T Cell Proliferation Figure 5. Que decreases the number of infiltrating T cells and protects mice from demyelination and OLs loss. Micrographs display the number of infiltrating CD4+ cells (red, A–D), MBP expression (Green, A,B) and oligodendrocytes (CC1+, Green, C,D) in the spinal cord of the EAE model with/without Que treatment. A–D: Clusters of infiltrating CD4+ cells are observed in the spinal cord without Que treatment (A, C) and, surrounding these areas, demyelination is present (arrowheads, A) and is devoid of oligodendrocytes (CC1+, arrowheads, C); Que treatment decreases PLOS ONE | www.plosone.org 7 August 2012 | Volume 7 | Issue 8 | e42746