Quantitative Mcm Perturbation in Mice Figure 5. Rescue of phenotypes by Mcm3 hemizygosity. (A) Heterozygosity for Mcm3Gt rescues the low viability of various mutant genotypes (asterisk indicates significance at P,0.05 by FET). The raw data are presented in Figure S4. (B) Male body weights of combination mutant mice. The weights of Mcm4Chaos3/Chaos3 Mcm2Gt/+ Mcm3Gt/+ mice are significantly higher (asterisk; P,0.01, Student’s t-test) at 90 days than Mcm4Chaos3/Chaos3 PLoS Genetics | www.plosgenetics.org 8 September 2010 | Volume 6 | Issue 9 | e1001110