Mediates an Anti-Inflammatory Activity of Chemerin in a Lung Disease Model. J Immunol 183: 6489–6499. 8. Bondue B, Vosters O, de Nada¨ı P, Glineur S, De Henau O et al. (2011) ChemR23 Dampens Lung Inflammation and Enhances Anti-viral Immunity in a Mouse Model of Acute Viral Pneumonia. PLoS Pathog 7(11): e1002358. doi:10.1371/journal.ppat.1002358. 9. Bondue B, Wittamer V, Parmentier M (2011) Chemerin and its receptors in the leukocyte trafficking, inflammation and metabolism. Cytokine Growth Factor Rev 22: 331–338. 10. Barnea G, Strapps W, Herrada G, Berman Y, Ong J et al. (2008) The genetic design of signaling cascades to record receptor activation. Proc Natl Acad Sci USA 105: 64–69. 11. Zabel BA, Nakae S, Zu´ n˜iga L, Kim JY, Ohyama T et al. (2008) Mast cell- expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis. J Exp Med 205: 2207–2220. 12. Otero K, Vecchi A, Hirsch E, Kearley J, Vermi W et al. (2010) Nonredundant role of CCRL2 in lung dendritic cell trafficking. Blood 116(6): 2942–2949. 13. Wittamer V, Gregoire F, Robberecht P, Vassart G, Communi D et al. (2004) The C-terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potency. J Biol Chem 279: 9956–9962. 14. Vermi W, Riboldi E, Wittamer V, Gentili F, Luini W et al. (2005) Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin. J Exp Med 201: 509–515. Chemerin Does Not Inhibit Inflammatory Responses 15. Wittamer V, Bondue B, Guillabert A, Vassart G, Parmentier M et al. (2005) Neutrophil-mediated maturation of chemerin: a link between innate and adaptive immunity. J Immunol 175: 487–493. 16. Zabel BA, Allen SJ, Kulig P, Allen JA, Cichy J et al. (2005) Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades. J Biol Chem 280: 34661–34666. 17. Goralski KB, McCarthy TC, Hanniman EA, Zabel BA, Butcher EC et al. (2007) Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. J Biol Chem 282: 28175–28188. 18. Bozaoglu K, Bolton K, McMillan J, Zimmet P, Jowett J et al. (2007) Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Endocri- nology 148: 4687–4694. 19. Roh SG, Song SH, Choi KC, Katoh K, Wittamer V et al. (2007) Chemerin- a new adipokine that modulates adipogenesis via its own receptor. Biochem Biophys Res Commun 362: 1013–1018. 20. Cash JL, Hart R, Russ A, Dixon JP, Colledge WH et al. (2008). Synthetic chemerin-derived peptides suppress inflammation through ChemR23. J Exp Med 205: 767–775. 21. Devosse T, Guillabert A, D’Haene N, Berton A, de Nadai P et al. (2009) Formyl peptide receptor-like 2 is expressed and functional in plasmacytoid dendritic cells, tissue-specific macrophage subpopulations, and eosinophils. J Immunol 182: 4974–4984. 22. Demoor T, Bracke KR, Dupond LL, Plantinga M, Bondue B et al. (2011) The role of ChemR23 in the induction and resolution of cigarette smoke-induced inflammation. J Immunol 186: 5457–5467. PLoS ONE | www.plosone.org 10 June 2012 | Volume 7 | Issue 6 | e40043