SU(HW) Fine-Tunes Nuclear Lamina Interactions Figure 1. Lamina associated domains in the Drosophila genome. (A) Genome – NL interaction maps in Drosophila Kc cells and human Lung Fibroblasts along a 4 Mb region at respectively chromosome 2L and chromosome 18. Human data are from [8]. Y-axes depict the log2 transformed Dam-LAM over Dam-only methylation ratio, smoothed by a running median of respectively 15 and 5 probes. Rectangles below each map represent calculated LAD positions for Drosophila (red) and human (blue). Grey rectangles at the bottom represent genes at the + and - strand. (B) Distribution of LAD sizes in Drosophila (red) and human cells (blue). Dashed lines mark the median LAD sizes. (C) Histogram of the number of genes per LAD. (D–F) Profiles across aligned LAD borders (824 borders, left and mirrored right borders combined). Running window median (red line) and a random PLoS ONE | www.plosone.org 3 November 2010 | Volume 5 | Issue 11 | e15013