HLA, HCP5 and ZNRD1 in HIV Figure 3. Disease-influencing effects associated with the HLA-B*57, HLA-C59 and HCP5 alleles in HIV-infected subjects from the WHMC cohort. (A–C) Plots are Kaplan-Meier curves for time to AIDS (1987 criteria). Disease-influencing effects in all subjects (left column), and in the European American (middle column) and African American (right column) components of the WHMC cohort that are associated with (A) HLA-B*57 alleles, (B) the SNP in HLA-C59 and (C) the SNP in HCP5. RH, relative hazards; CI, confidence interval; P, significance value obtained by Cox proportional hazards modeling; n, number of subjects. (D) Distribution of the indicated alleles in the WHMC HIV+ cohort stratified according to time to AIDS or duration of AIDS-free status. These are indicated as time to AIDS in ,2, 2 to ,5, and $5 years, and no development of AIDS during the first 10 years or after 10 or more years of follow- up. For example, within each panel the left-most bar corresponds to subjects who developed AIDS within 2 years while the right-most bar indicates subjects who did not develop AIDS after 10 or more years of follow-up. At the bottom of each panel is shown significance value (obtained using chi-square test for linear trend) for a linear trend in the proportion of subjects possessing the indicated allele. doi:10.1371/journal.pone.0003636.g003 PLoS ONE | www.plosone.org 8 November 2008 | Volume 3 | Issue 11 | e3636