Genome-Wide Screen for G6E Interactions on Lipids Figure 1. Forest plot of main and WHR interaction effect sizes of rs6448771 on TC across the study cohorts. The circles in the plot are positioned at the effect estimates, betas, and the size corresponds to the number of individuals. The whiskers correspond to the standard errors of betas. doi:10.1371/journal.pgen.1002333.g001 ascertained on the basis of phenotype, with a wide variety of well- defined epidemiological measures available, were included. In the replication datasets, the NTR cohort was selected on the basis of low risk for depression and the Genmets samples were selected for metabolic syndrome. In further replication of rs6448771, the EPIC cases were ascertained by BMI. Descriptive statistics for PLoS Genetics | www.plosgenetics.org 5 October 2011 | Volume 7 | Issue 10 | e1002333