CCR2 Blocker Inhibits Choroidal Neovascularization Figure 1. Effect of INCB3344 on CNV formation. (A) Haematoxylin–eosin-stained light micrograph of CNV lesions on Day 14 after laser photocoagulation. Each photograph shows the central area of CNV lesions in vehicle-treated or INCB3344-treated mice. Scale bar = 100 mm. (ILM: internal limiting membrane; NFL: nerve fiber layer; GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer; IS: inner segment; OS: outer segment; RPE: retinal pigment epithelium; C: choroid; S: sclera). (B) Representative micrographs of CNV lesions in the choroid-RPE flat mounts from laser-induced CNV in mice treated with vehicle or INCB3344. CNV areas were PLoS ONE | www.plosone.org 4 December 2011 | Volume 6 | Issue 12 | e28933