References 1. Proenc¸a-Mo´dena JL, Macedo IS, Arruda E (2007) H5N1 avian influenza virus: an overview. Braz J Infect Dis 11: 125–133. 2. Beigel JH, Farrar J, Han AM, Hayden FG, Hyer R, et al. (2005) Avian influenza A (H5N1) infection in humans. N Engl J Med 353: 1374–1385. 3. Ungchusak K, Auewarakul P, Dowell SF, Kitphati R, Auwanit W, et al. (2005) Probable person-to-person transmission of avian influenza A (H5N1). N Engl J Med 352: 333–340. 4. Kandun IN, Wibisono H, Sedyaningsih ER, Yusharmen, Hadisoedarsuno W, et al. (2006) Three Indonesian clusters of H5N1 virus infection in 2005. N Engl J Med 355: 2186–2194. 5. Stohr K, Esveld M (2004) Public health. Will vaccines be available for the next influenza pandemic? Science 306: 2195–2196. 6. Lipsitch M, Cohen T, Murray M, Levin BR (2007) Antiviral Resistance and the Control of Pandemic Influenza. PLoS Medicine 4: e15. 7. Aledort JE, Lurie N, Wasserman J, Bozzette SA (2007) Non-pharmaceutical public health interventions for pandemic influenza: an evaluation of the evidence base. BMC Public Health 7: 208. 8. Aiello AE, Coulborn R, Perez V, Larson EL (2008) Effect of Hand Hygiene on Infectious Disease Risk in the Community Setting: A Meta-Analysis. Am J Public Health (in press). 9. Jefferson T, Foxlee R, Mar CD, Dooley L, Ferroni E, et al. (2008) Physical interventions to interrupt or reduce the spread of respiratory viruses: systematic review. BMJ 336: 77–80. 10. Epstein JM, Goedecke DM, Yu F, Morris RJ, Wagener DK, et al. (2007) Controlling Pandemic Flu: The Value of International Air Travel Restrictions. PLoS ONE 2: e401. 11. World Health Organization (WHO) Writing Group (2006) Nonpharmaceutical Interventions for Pandemic Influenza, International Measures. Emerg Infect Dis 12: 81–87. 12. World Health Organization (WHO) Writing Group (2006) Nonpharmaceutical Interventions for Pandemic Influenza, National and Community Measures. Emerg Infect Dis 12: 88–94. 13. Wong CM, Chan KP, Hedley AJ, Peiris JS (2004) Influenza-associated mortality in Hong Kong. Clin Infect Dis 39: 1611–1617. 14. Monto AS (1999) Individual and community impact of influenza. Pharmacoe- conomics 16 Suppl 1: 1–6. 15. Molinari NA, Ortega-Sanchez IR, Messonnier ML, Thompson WW, Wortley PM, et al. (2007) The annual impact of seasonal influenza in the US: measuring disease burden and costs. Vaccine 25: 5086–5096. 16. Campbell MK, Elbourne DR, Altman DG, group C (2004) CONSORT statement: extension to cluster randomised trials. BMJ 328: 702–708. 17. World Medical Association (2000) World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA 284: 3043–3045. 18. Larson EL (1995) APIC guideline for handwashing and hand antisepsis in health care settings. Am J Infect Control 23: 251–269. 19. Monto AS, Pichichero ME, Blanckenberg SJ, Ruuskanen O, Cooper C, et al. (2002) Zanamivir prophylaxis: an effective strategy for the prevention of influenza types A and B within households. J Infect Dis 186: 1582–1588. 20. Babcock HM, Merz LR, Fraser VJ (2006) Is influenza an influenza-like illness? Clinical presentation of influenza in hospitalized patients. Infect Control Hosp Epidemiol 27: 266–270. Effectiveness of NPIs for Flu 21. Viboud C, Boelle PY, Cauchemez S, Lavenu A, Valleron AJ, et al. (2004) Risk factors of influenza transmission in households. Br J Gen Pract 54: 684– 689. 22. Donner A, Klar N (2000) Design and analysis of cluster randomization trials in health research. London: Arnold. 23. Liang K-Y, Zeger SL (1986) Longitudinal data analysis using generalized linear models. Biometrika 73: 13–22. 24. Pepe MS (2003) The Statistical Evaluation of Medical Tests for Classification and Prediction. New York: Oxford University Press. 25. R Development Core Team (2004) R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing. 26. Tellier R (2006) Review of aerosol transmission of influenza A virus. Emerg Infect Dis 12: 1657–1662. 27. Jefferson T, Foxlee R, Mar CD, Dooley L, Ferroni E, et al. (2007) Physical interventions to interrupt or reduce the spread of respiratory viruses: systematic review. BMJ (in press). 28. Lo JY (2005) Respiratory Infections during SARS Outbreak, Hong Kong, 2003. Emerg Infect Dis 11: 1738–1741. 29. Leung GM, Ho LM, Chan SK, Ho SY, Bacon-Shone J, et al. (2005) Longitudinal assessment of community psychobehavioral responses during and after the 2003 outbreak of severe acute respiratory syndrome in Hong Kong. Clin Infect Dis 40: 1713–1720. 30. Sandora TJ, Taveras EM, Shih MC, Resnick EA, Lee GM, et al. (2005) A randomized, controlled trial of a multifaceted intervention including alcohol- based hand sanitizer and hand-hygiene education to reduce illness transmission in the home. Pediatrics 116: 587–594. 31. Fox JP (1980) Viruses in families. Littleton Mass.: PSG Pub. Co. 32. King JC Jr., Stoddard JJ, Gaglani MJ, Moore KA, Magder L, et al. (2006) Effectiveness of school-based influenza vaccination. N Engl J Med 355: 2523–2532. 33. Monto AS, Gravenstein S, Elliott M, Colopy M, Schweinle J (2000) Clinical signs and symptoms predicting influenza infection. Arch Intern Med 160: 3243–3247. 34. Zambon M, Hays J, Webster A, Newman R, Keene O (2001) Diagnosis of influenza in the community: relationship of clinical diagnosis to confirmed virological, serologic, or molecular detection of influenza. Arch Intern Med 161: 2116–2122. 35. Friedman MJ, Attia MW (2004) Clinical predictors of influenza in children. Arch Pediatr Adolesc Med 158: 391–394. 36. Ohmit SE, Monto AS (2006) Symptomatic predictors of influenza virus positivity in children during the influenza season. Clin Infect Dis 43: 564–568. 37. Carrat F, Tachet A, Rouzioux C, Housset B, Valleron AJ (1999) Evaluation of clinical case definitions of influenza: detailed investigation of patients during the 1995–1996 epidemic in France. Clin Infect Dis 28: 283–290. 38. Call SA, Vollenweider MA, Hornung CA, Simel DL, McKinney WP (2005) Does this patient have influenza? JAMA 293: 987–997. 39. Uyeki TM (2003) Influenza diagnosis and treatment in children: a review of studies on clinically useful tests and antiviral treatment for influenza. Pediatr Infect Dis J 22: 164–177. 40. Morse SS, Garwin RL, Olsiewski PJ (2006) Public health. Next flu pandemic: what to do until the vaccine arrives? Science 314: 929. PLoS ONE | www.plosone.org 9 May 2008 | Volume 3 | Issue 5 | e2101