Table 4. Association results on Kosrae for select previously known, associated loci. GWAS on the Island of Kosrae Caucasian Kosraen Study Nearest Gene(s) Allele Freq P-value b on 500 k Freq P-value b Phet b Phet Freq PLoS Genetics | www.plosgenetics.org February 2009 | Volume 5 | Issue 2 | e1000365 SNP BMI rs9939609 rs17782313 Height rs6763931 rs724016 rs1042725 rs6060369 rs798544 rs3748069 rs1812175 rs7153027 rs6830062 rs3760318 rs2282978 rs967417 rs4743034 rs678962 rs4533267 rs7846385 rs2562784 rs4794665 1 2 3 4 4 4 3 3 3 3 3 3 3 3 3 3 3 3 4 3 HDL-C rs1800775 5 rs4846914 5 rs2156552 5 rs3890182 5 rs328 5 LDL-C rs12654264 5 rs693 5 rs4420638 5 rs16996148 5 Triglycerides rs328 5 rs693 5 rs12130333 5 rs780094 5 rs17321515 5 rs16996148 5 rs4846914 5 rs17145738 5 Fasting plasma glucose rs563694 6 rs1799884 7 CETP GALNT2 LIPG, ACAA2 ABCA1 LPL HMGCR APOB APOE cluster CILP2,PBX4 LPL APOB ANGPTL3, DOCK7,ATG4C GCKR TRIB1 CILP2,PBX4 GALNT2 BCL7B,TBL2,MLXIPL G6PC2 GCK FTO MC4R ZBTB38 A ZBTB38 G HMGA2 T GDF5-UQCC C GNA12 G GPR126 A HHIP C TRIP11, FBLN5, ATXN3, A CPSF2 LCORL, NCAPG T CRLF3, ATAD5, CENTA2, C RNF135 CDK6, PEX1, GATAD1, C ERVWE1 BMP2 C ZNF462 A DNM3 G ADAMTS17 A PXMP3, ZFHX4 C SH3GL3-ADAMTSL3 G NOG, DGKE, TRIM25, COIL, A RISK A C C G A A G T A G T G A T T G T G T A A 0.45 0.28 0.48 0.48 0.49 0.36 0.72 0.73 0.81 0.61 0.84 0.64 0.37 0.57 0.24 0.16 0.28 0.34 0.17 0.53 0.43 0.42 0.20 0.09 0.13 0.42 0.49 0.18 0.06 0.13 0.49 0.24 0.38 0.40 0.06 0.42 0.12 0.65 0.20 2.0E-20 2.8E-15 1.4E-27 8.3E-22 2.7E-20 1.4E-16 6.5E-15 4.5E-14 9.7E-12 1.1E-10 1.3E-10 1.8E-09 9.8E-09 1.5E-08 2.1E-08 3.2E-08 3.3E-08 4.7E-08 6.4E-08 9.9E-08 1.0E-73 2.0E-13 2.0E-07 3.0E-10 9.0E-23 1.0E-20 1.0E-21 1.0E-60 3.0E-08 2.0E-28 2.0E-07 2.0E-08 3.0E-14 4.0E-17 4.0E-09 7.0E-15 7.0E-22 6.4E-33 1.0E-09 12 0.10 0.05 same same 0.07 rs6440003 0.37 rs6440003 20.48 same 0.44 same 0.06 same 0.07 rs7755109 0.08 same 0.06 same 0.06 0.06 0.06 0.04 0.05 0.05 0.06 0.05 0.34 0.04 same rs7225461 same same same rs12411264 same same same same 20.18 same 20.07 same 20.07 same 20.10 same 0.17 rs10503669 0.10 same 0.12 same 0.19 same 20.10 same 20.19 rs10503669 0.08 same 20.11 same 0.13 same 20.08 same 20.10 same 0.08 same 20.14 same 0.06 same same 0.12 0.08 0.25 0.25 0.55 0.31 0.47 0.25 0.63 0.77 0.94 0.56 0.06 0.13 0.14 0.14 0.40 0.16 0.42 0.26 0.58 0.58 0.03 0.37 0.98 0.42 0.09 0.21 0.17 0.98 0.09 0.04 0.27 0.70 0.17 0.58 0.03 0.95 0.14 0.10 0.55 0.16 0.16 0.70 0.51 0.18 0.36 0.05 0.46 0.86 0.31 0.61 0.90 0.41 0.77 0.19 1.00 0.20 0.65 1.7E-04 0.58 0.45 0.18 0.04 2.4E-05 0.15 1.9E-07 0.58 0.53 0.17 0.87 1.5E-02 1.3E-02 1.6E-03 1.6E-03 0.79 0.28 0.06 0.14 0.65 20.06 0.26 0.08 0.88 0.08 2.8E-06 0.01 5.5E-42 0.05 5.2E-08 0.08 0.68 0.07 0.92 0.11 0.60 20.06 0.14 0.03 0.07 0.80 0.90 20.07 0.33 0.03 0.97 20.10 0.21 20.01 0.06 0.07 0.76 20.01 1.00 20.08 2.9E-11 20.04 0.40 20.19 0.86 20.03 0.34 0.10 2 0.07 6.8E-04 20.38 2 0.18 0.07 0.11 0.88 0.30 0.05 20.03 0.11 0.10 2 0.10 0.81 0.02 2 0.12 0.88 20.11 0.47 20.16 0.25 20.16 2.0E-06 20.02 2 0.21 0.15 2 0.26 0.16 0.42 2 2 0.84 0.85 0.18 2 0.48 0.47 0.60 2 0.10 0.05 0.71 2 0.51 0.26 0.15 0.33 0.55 0.54 0.24 0.12 2 1.00 0.05 0.92 0.66 2 0.05 0.44 0.68 0.20 0.66 0.54 0.73 0.13 0.82