The LARGE Principle in AFiPSCs Figure 4. Global gene expression analyses of AFCs, AFiPSCs and ESCs. Transcriptome analyses of AFCs, AFiPSCs, ESCs (H1 and H9) using Illumina bead chips. (A) Hierarchical clustering based on detected gene expression using Pearson’s correlation. (B) Table showing linear correlation coefficients (R2) between samples. Low R2 values (around 0.67) were detected between AFCs and AFiPSCs. ESCs and AFiPSCs exhibited high R2 values (around 0.94). (C) Venn diagram based on detected genes in AFCs, AFiPSCs and ESCs portraying distinct and overlapping transcriptional signatures between the different cell types. doi:10.1371/journal.pone.0013703.g004 PLoS ONE | www.plosone.org 8 October 2010 | Volume 5 | Issue 10 | e13703