Novel Candidate Biomarkers in Melanomas Figure 5. Epigenetic Flexibility in Human Specimens. (A) Changes on cell morphology of human primary melanocytes after their exposure to epigenetic modifier drugs, specially the combined therapy between 5AzaCdR and TSA. (B) Differential expression of XIST gene between two female patient-derived metastatic melanoma cell lines. (C-E) Expression of genes HSPB1, SERPINE1 and FBLIM1 was modulated in response to epigenetic compounds in human primary melanocytes and metastatic melanoma cells. Differential expression in a panel of five early-passage patient-derived PLOS ONE | www.plosone.org 10 September 2012 | Volume 7 | Issue 9 | e44800