Genome-Wide Profiling of MicroRNAs Figure 5. Differential expression of miRNAs in epididymal fat pads from mouse models of genetically or diet induced obesity. A: Epididymal fat pad weights were compared of obese ob/ob mice and wild-type controls (Ob/ob model) and of wt or PPARc DN mice fed either a chow or a high-fat diet (DIO model). B: miRNA levels were analyzed in epididymal fat pads from five wild-type (WT) and five leptin-deficient ob/ob mice by real-time-PCR. Data were normalized to SNORA73A expression. The relative expression levels compared to wild-type mice were plotted and PLoS ONE | www.plosone.org 8 June 2011 | Volume 6 | Issue 6 | e21305