38. Ono M (2008) Molecular links between tumor angiogenesis and inflammation: inflammatory stimuli of macrophages and cancer cells as targets for therapeutic strategy. Cancer Sci 99: 1501–1506. 39. Naik E, Dixit VM (2011) Mitochondrial reactive oxygen species drive proinflammatory cytokine production. J Exp Med 208: 417–420. 40. Shibuya T, Watanabe K, Yamashita H, Shimizu K, Miyashita H, et al. (2006) Isolation and characterization of vasohibin-2 as a homologue of VEGF-inducible endothelium-derived angiogenesis inhibitor vasohibin. Arterioscler Thromb Vasc Biol 26: 1051–1057. 41. Chen J, Patschan S, Goligorsky MS (2008) Stress-induced premature senescence of endothelial cells. J Nephrol 21: 337–344. 42. Nasu T, Maeshima Y, Kinomura M, Hirokoshi-Kawahara K, Tanabe K, et al. (2009) Vasohibin-1, a negative feedback regulator of angiogenesis, ameliorates renal alterations in a mouse model of diabetic nephropathy. Diabetes 58: 2365– 2375. 43. Han MK (2011) Update in chronic obstructive pulmonary disease in 2010. Am J Respir Crit Care Med 183: 1311–1315. VASH1 Enhances Stress Resistance of Endothelium 44. Jerkic M, Kabir MG, Davies A, Yu LX, McIntyre BA, et al. (2011) Pulmonary hypertension in adult Alk1 heterozygous mice due to oxidative stress. Cardiovasc Res 92: 375–384. 45. de Perrot M, Liu M, Waddell TK, Keshavjee S (2003) Ischemia-reperfusion- induced lung injury. Am J Respir Crit Care Med 167: 490–511. 46. Nakamaru Y, Vuppusetty C, Wada H, Milne JC, Ito M, et al. (2009) A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9. FASEB J 23: 2810–2819. 47. Rajendrasozhan S, Yang SR, Kinnula VL, Rahman I (2008) SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 177: 861– 870. 48. Siedlinski M, van Diemen CC, Postma DS, Vonk JM, Boezen HM (2009) Superoxide dismutases, lung function and bronchial responsiveness in a general population. Eur Respir J 33: 986–992. PLOS ONE | www.plosone.org 12 October 2012 | Volume 7 | Issue 10 | e46459