B. mori Host Response to Bb Figure 8. Bb induced silkworm cellular immune response and serine protease cascade melanization pathway. (a) Cluster of cellular immune response families. (b) Cluster diagram of the induced synthesis of melanin by serine protease cascade melanization pathway related genes. For a detailed view of the cluster ratios, see Table S4. (c) Real time PCR analysis of ppo1 and ppo2 ratios of Bb infected whole larvae comparing to non-induced control and 490 nm absorbance of hemolymph during the infection, and the picture of the hemolymph melanization 3 h after Bb oral infection. doi:10.1371/journal.pone.0008098.g008 PLoS ONE | www.plosone.org 11 December 2009 | Volume 4 | Issue 12 | e8098