CDC25A-Q110del Novel Isoform Role in Lung Cancer Figure 1. Identification of CDC25AQ110del isoform in NSCLC cell lines. A. Nucleic acid sequence of triplicate deletion CDC25A-CAG (328–30) in NSCLC cell lines. B. CDC25A-CAG (328–30) translates to Q110 deletion (CDC25AQ110del). C. Amino acid Q110 of CDC25A is evolutionary conserved in other organisms. D. Q110 lies in the regulatory domain, closest to CDK1 mitotic stabilization phosphorylation site (S116) and Chk1 degredation phosphorylation site (S124). Red: CAG (328–30) nucleic acid deletion and corresponding amino acid Q110, shade: serine phosphorylation sites (S116 PLOS ONE | www.plosone.org 3 October 2012 | Volume 7 | Issue 10 | e46464