Fto and Postnatal Growth Figure 3. Complete knockout of Fto results in postnatal growth retardation. (A) Representative pictures of wildtype and Fto knockout mice at different ages. (B) Growth curves of Fto+/+, Fto+/D, and FtoD/D mice from postnatal day 1 to 7. n = 16/16/14 (Fto+/+/Fto+/D/FtoD/D). P-values from day 1 to 7: 0.29, 0.062, 0.011, 0.0069, 0.0007, ,0.0001, and ,0.0001. (C) Body weights of Fto+/+, Fto+/D and FtoD/D embryos at E18.5. n = 11/19/12 (Fto+/+/ Fto+/D/FtoD/D). P = 0.68. (D) Growth curves of male and female Fto+/+, Fto+/D and FtoD/D mice. For each genotype (Fto+/+/Fto+/D/FtoD/D), n = 26/31/33 (male), n = 27/37/49 (female). **P,0.01 for all the time points, except in females at 12 weeks old, P = 0.024. (E) Body length of adolescent and adult PLoS ONE | www.plosone.org 5 November 2010 | Volume 5 | Issue 11 | e14005