Coaction of CCSCs/EPCs Promotes Development of CC Figure 8. Cancer stem cells promote angiogenesis in human colon cancers. (A) More microvessels in cancer tissue than normal tissue were observed by immunofluorescent staining of CD133 and CD31 of normal mucosa and colon cancer. And higher MVD were found in the area enriching CD133+ cancer stem cells in colon cancer tissue. (B) Higher MVD (CD31+) were found in the area enriching Lgr5+ cancer stem cells in colon cancer tissue. doi:10.1371/journal.pone.0039069.g008 PLoS ONE | www.plosone.org 11 June 2012 | Volume 7 | Issue 6 | e39069