Supporting Information Figure S1 Immunohistochemistry with antibodies to FKBP12 on paraffin embedded human breast carcinomas showed locali- zation of FKBP12 to endothelium. Arrows point to vessels. Pictures taken at 2006 magnification. A) Negative control showed no background staining. B) Mouse MMTV-neu tumor showed FKBP12 staining of vessels. C & D) Human breast tumors showed FKBP12 staining of vessels. (DOC) Figure S2 Full length blot/gels with molecular markers. A) Western blot results of siRNA to beta catenin shows beta catenin is present in 2H11 endothelial cells and sham-transfected 2H11 endothelial cells, but reduced in siRNA to beta catenin transfected 2H11 endothelial cells. B) Western blot results of ShRNA to SFRP2 in 2H11 endothelial cells showed increased NFATc3 protein in 2H11 endothelial cells stimulated with 7 nM SFRP2 compared to control 2H11 endothelial cells. This effect is References 1. Minami T, Horiuchi K, Miura M, Abid MR, Takabe W, et al. 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