(which depends in a nonlinear way on population density). - Total: The sum of the number of people covered by ITN, IRS and EM, adjusted for an overlapping factor of 50% (i.e., multiplied by a factor of 0.5). See references [49–66]. (DOC) Text S1 Technical appendix with all model equations. The technical appendix lists all the equations used in the Malaria Management Model. Initial values and parameter values are those from the baseline simulation. The simulation model is also available as online supporting information (Dataset S1 and Dataset S2). (DOC) Dataset S1 MMM model running in the Vensim H software package. This supporting information dataset is the Malaria Management Model that runs in the Vensim H DSS software package. The model has to be completed with the data file (Dataset S2). (MDL) References 1. Alonso PL, Brown G, Arevalo-Herrera M, Binka F, Chitnis C, et al. (2011) A research agenda to underpin malaria eradication. PLoS Medicine 8: e1000406. 2. 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Population Division of the Department of Economic and Social Affairs of the United Nations Secretariat (2010) World Population Prospects: The 2010 Revision. 38. Snow RW, Guerra CA, Noor AM, Myint HY, Hay SI (2005) The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature 434: 214–217. 39. Roll Back Malaria (2008) The global malaria action plan. For a malaria-free world. Geneva: The Roll Back Malaria Partnership. 40. Trape J-F, Tall A, Diagne N, Ndiath O, Ly AB, et al. (2011) Malaria morbidity and pyrethroid resistance after the introduction of insecticide-treated bednets and artemisinin-based combination therapies: a longitudinal study. The Lancet Infectious Diseases;doi:10.1016/S1473-3099(1011)70194-70193. PLoS ONE | www.plosone.org 11 November 2011 | Volume 6 | Issue 11 | e27771