Targeted Killing of CSCs by CDF Figure 5. CDF decreased the formation of pancreatospheres in AsPC-1 and AsPC-1-GTR cells 1 week treatment (A); 4 weeks treatment (B); AsPC-1 and CDF-pre-treated AsPC-1 cells treated with gemcitabine and CDF (C). A significant reduction in pancreatospheres was observed in cells treated with CDF shown by asterisk. doi:10.1371/journal.pone.0017850.g005 PLoS ONE | www.plosone.org 6 March 2011 | Volume 6 | Issue 3 | e17850