Role of PI3KC2b in RhoA Activation 56. Russo C, Gao Y, Mancini P, Vanni C, Porotto M, et al. (2001) Modulation of oncogenic DBL activity by phosphoinositol phosphate binding to pleckstrin homology domain. J Biol Chem 276: 19524–19531. 57. Hall A, Nobes CD (2000) Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton. Philos Trans R Soc Lond B Biol Sci 355: 965–970. 58. Jiang K, Sun J, Cheng J, Djeu JY, Wei S, et al. (2004) Akt mediates Ras downregulation of RhoB, a suppressor of transformation, invasion, and metastasis. Mol Cell Biol 24: 5565–5576. 59. Coleman ML, Olson MF (2002) Rho GTPase signalling pathways in the morphological changes associated with apoptosis. Cell Death Differ 9: 493–504. 60. Perona R, Esteve P, Jimenez B, Ballestero RP, Ramon y Cajal S, et al. (1993) Tumorigenic activity of rho genes from Aplysia californica. Oncogene 8: 1285– 1292. 61. Qiu RG, Chen J, Kirn D, McCormick F, Symons M (1995) An essential role for Rac in Ras transformation. Nature 374: 457–459. 62. Qiu RG, Chen J, McCormick F, Symons M (1995) A role for Rho in Ras transformation. Proc Natl Acad Sci U S A 92: 11781–11785. 63. Liu Z, Sun C, Zhang Y, Ji Z, Yang G (2010) Phosphatidylinositol 3-kinase- C2beta inhibits cisplatin-mediated apoptosis via the Akt pathway in oesophageal squamous cell carcinoma. J Int Med Res 39: 1319–1332. PLOS ONE | www.plosone.org 14 September 2012 | Volume 7 | Issue 9 | e44945