P2Y12 in Atherothrombosis Figure 1. Inhibition of P2Y12 receptors causes unstable thrombus formation on acutely ruptured plaques in mice. Apoe2/2 mice were infused with vehicle solution as a control. Other mice were infused with ticagrelor (210 mg/kg for 1 min, followed by 30 mg/kg/min during the experiment). In the third group of mice, cangrelor was continuously infused at 3 mg/kg/min. Infusion of ticagrelor and cangrelor started at 15 min PLoS ONE | www.plosone.org 4 April 2010 | Volume 5 | Issue 4 | e10130