Glutamate Receptors Editing Figure 11. KA-induced expression of genes involved in the neuroinflammatory response in the hippocampus of COX-2+/+ and COX- 22/2 mice. Quantitative real time-PCR analysis of TNF-a (A), IL-1b (B), IL-6 (C), NF-kB (D), GFAP (E), CD11b (F), iNOS (G), MAP-2 (H) for COX-2+/+ and COX-22/2 mice 24 h after i.p. injection of KA or vehicle. Data are means 6 SEM (n = 9). Statistical analysis was performed using a two-way ANOVA and Bonferroni’s post-hoc test to compare replicate means. *P,0.05, **P,0.01, ***P,0.001 compared to vehicle-injected COX-2+/+ mice; #P,0.05, ##P,0.01, ###P,0.001, compared to vehicle-injected COX-22/2 mice; ﬁP,0.05, ﬁﬁP,0.01, ﬁﬁﬁP,0.001 between KA-injected COX-22/2 and KA-injected WT mice. doi:10.1371/journal.pone.0019398.g011 PLoS ONE | www.plosone.org 15 May 2011 | Volume 6 | Issue 5 | e19398