Agent-Based Modeling Figure 6. Endotoxin tolerance scenario. Pre-existing infection might cause a profound reduction in cell’s capacity (hypo-responsiveness) to respond in the main endotoxin challenge. Solid line: LPS(t = 0 hr) = 750. Dotted line: LPS(t = 0 hr) = 100 & LPS(t = 8 hr) = 650. doi:10.1371/journal.pone.0009249.g006 Figure 7. Lethal potentiation. Successive administration of small doses of endotoxin can lead to an unresolved inflammatory response. Solid line: LPS(t = 0 hr) = 350. Dotted line: LPS(t = 0 hr) = 100 & LPS(t = 2 hr) = 250. doi:10.1371/journal.pone.0009249.g007 PLoS ONE | www.plosone.org 9 February 2010 | Volume 5 | Issue 2 | e9249