IL-36a and Pulmonary Inflammation Figure 6. IL-36a induced the expression of proinflammatory cytokines and chemokines in splenic CD11c+ cells. A–H) Transcript expression of early response cytokines (TNFa, IL-1a, IL-1b, IL-36c), the classical IL-1 receptor IL-1R1, the novel IL-1 cytokine cluster receptor IL-36R as well as the neutrophil specific chemokines CXCL1 and CXCL2 in splenic CD11c+ cells 2 h following incubation with increasing concentrations of IL- PLOS ONE | www.plosone.org 10 September 2012 | Volume 7 | Issue 9 | e45784