43. Godefroy E, Moreau-Aubry A, Diez E, Dreno B, Jotereau F, et al. (2005) alpha v beta3-dependent cross-presentation of matrix metalloproteinase-2 by melanoma cells gives rise to a new tumor antigen. J Exp Med 202: 61–72. 44. Charo IF, Nannizzi L, Smith JW, Cheresh DA (1990) The vitronectin receptor alpha v beta 3 binds fibronectin and acts in concert with alpha 5 beta 1 in promoting cellular attachment and spreading on fibronectin. J Cell Biol 111: 2795–2800. MMP-2 Promotes avb3 Mediated Tumor Cell Migration 45. Galardy RE, Cassabonne ME, Giese C, Gilbert JH, Lapierre F, et al. (1994) Low molecular weight inhibitors in corneal ulceration. Ann. N. Y. Acad. Sci., 732: 315–23. 46. Ogier C, Bernard A, Chollet AM, LE Diguardher T, Hanessian S, et al. (2006) Matrix metalloproteinase-2 (MMP-2) regulates astrocyte motility in connection with the actin cytoskeleton and integrins. Glia 54: 272–284. 47. Kenny HA, Kaur S, Coussens LM, Lengyel E (2008) The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin. J Clin Invest 118: 1367–1379. PLoS ONE | www.plosone.org 12 July 2012 | Volume 7 | Issue 7 | e41591