Inhibition of PAK Reduces Airway Responsiveness Figure 5. Comparison of the Lung Parenchyma (N = 3–5 in each group) for WT (black) and Pak12/2 (grey) mice. There were no significant differences for lung volumes at 30 cmH2O (p.0.37) (A); pressure volume curves normalized to volume at 30 cmH2O (B); or Alveolar Mean Linear Intercepts (MLI) (p.0.40) (C). doi:10.1371/journal.pone.0042601.g005 Figure 6. Comparison of Lung Histology for WT and Pak12/2 mice. Airway wall area (A), airway smooth muscle area (B), and airway epithelium area (C) were not significantly different between the WT (black squares) and Pak12/2 (grey circles) mice when assessed by ANOVA adjusting for airway perimeter (p.0.15). (N = 5 mice in each group). doi:10.1371/journal.pone.0042601.g006 PLOS ONE | www.plosone.org 5 August 2012 | Volume 7 | Issue 8 | e42601