Signature in Renal Carcinoma Table 1. Pathway signature of clear cell renal cell carcinoma. Overall Rank Gene Set Category Pathway Set Size % Up NTk Rank NEk Rank 1 7 8 28 40 22 26 16 27 2 4 15 32 5 6 10 12 18 21 23 25 29 31 3 24 33 34 35 37 36 38 9 11 13 14 17 19 20 30 39 GO:0007588 GO:0006814 GO:0031402 GO:0006821 GO:0005249 GO:0006818 GO:0015992 GO:0051258 GO:0016830 KEGG KEGG KEGG KEGG GO:0016614 GO:0016616 GO:0045333 GO:0016903 GO:0006752 GO:0006119 GO:0016627 KEGG GO:0006753 GO:0005743 KEGG BioCyc GO:0044270 GO:0009310 GO:0009063 GO:0008652 KEGG KEGG GO:0009615 GO:0030333 GO:0019882 GO:0019883 GO:0050865 GO:0019885 GO:0051249 GO:0003690 GO:0003777 Pathways related to normal renal function excretion sodium ion transport sodium ion binding chloride transport voltage-gated potassium channel activity hydrogen transport proton transport Metabolic pathways protein polymerization carbon-carbon lyase activity Lipid metabolic pathways Butanoate_metabolism Propanoate_metabolism Fatty_acid_metabolism Benzoate_degradation_via_CoA_ligation Energy metabolic pathways oxidoreductase activity, acting on CH-OH group of donors oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor cellular respiration oxidoreductase activity, acting on the aldehyde or oxo group of donors group transfer coenzyme metabolism oxidative phosphorylation oxidoreductase activity, acting on the CH-CH group of donors ATP_synthesis nucleoside phosphate metabolism mitochondrial inner membrane Protein and amino acid metabolic pathways Valine,_leucine_and_isoleucine_degradation valine degradation I nitrogen compound catabolism amine catabolism amino acid catabolism amino acid biosynthesis Carbohydrate metabolic pathways Fructose_and_mannose_metabolism Pentose_phosphate_pathway Immune pathways response to virus antigen processing antigen presentation antigen presentation, endogenous antigen regulation of cell activation antigen processing, endogenous antigen via MHC class I regulation of lymphocyte activation Other pathways double-stranded DNA binding microtubule motor activity 40 59 53 25 38 56 55 33 28 49 42 69 63 83 75 34 31 59 72 34 44 43 70 55 21 55 53 52 34 48 25 43 42 46 25 22 25 20 25 33 2 12 11 20 42 7 7 79 29 2 5 6 30 16 13 6 19 8 1 21 5 2 7 7 14 11 11 10 38 38 40 86 98 89 100 86 100 85 76 39 3 10 12 104 354 18 21 56 102 1 6 11 122 9 8 19 50 15 2 68 23 25 14 4 86 16 24 22 247 187.5 247 17 5 7 13 48 20 64 110 316 4 15 21 5 24 69 79 8 1 10 16 53 7 13 17 25 2 56 77 19 73 96 109 9 3 122 136 139 12 6 22 18 44 50 47 20 52 14 11 23 PLoS ONE | www.plosone.org 3 May 2010 | Volume 5 | Issue 5 | e10696