Gene Symbol Cdkn1a Ephx1 Phlda3 Plat Tmem178 AB023957 Gstm6 Nrp1 Icam1 Tmem43 Gpnmb LOC10004 E430002G Slc19a2 Pax1 Gas6 Anxa8 Mmp2 Aaas Ahnak2 Timp3 LOC10004 Angptl4 Slc16a9 Slc29a3 Tnfrsf11b/Opg Lgr5 Scd2 Prelp Bcl11b Cxcl2 Exoc4 Lgals3bp Prad1 Tpm1 Ror2 Palld Sfrp4 Col5a1 Hmgcs2 Polk Axin2 Rnf145 *3SD; #.2 SD; ‘ .1 SD. doi:10.1371/journal.pone.0011492.t001 Fold Change 3.4 * 2.8 * 2.0 * 2.0 * 2.0 * 1.9 * 1.9 # 1.8 * 1.8 # 1.7 # 1.7 # 1.7 # 1.7 # 1.6 # 1.6 # 1.6 # 1.6 # 1.6 # 1.6 # 1.6 # 1.6 # 1.6 # 1.6 # 1.6 # 1.6 # 1.6 ‘ 1.6 # 1.5 # 1.5 # 1.5 # 1.5 # 1.5 # 1.5 # 1.5 ‘ 1.5 ‘ 1.4 ‘ 1.4 # 1.4 ‘ 1.4 ‘ 1.4 ‘ 1.4 ‘ 1.4 ‘ 1.4 ‘ S100a8 Alas2 Ramp1 Rsad2 Mepe Hdac3 Serpina3g Vit Hpgd CD59a Entpd3 Sct Gpihbp1 Hey1 CD59b Icam2 Ankrd37 Prr15 Cdk5r1 Ndufa1 Rbp7 Hdac3 Regulates Bone Density 27.3 * 22.6 * 22.3 * 22.2 * 22.0 * 22.0 # 21.9 # 21.9 # 21.8 # 21.7 # 21.6 # 21.6 ‘ 21.6 # 21.6 # 21.6 # 21.6 # 21.5 # 21.5 ‘ 21.5 # 21.4 ‘ 21.4 ‘ Table 1. Genes Differentially Regulated in Calvarial Osteoblasts from Hdac3 CKO Mice. Genes Upregulated in Hdac3 CKO Mice Genes Downregulated in Hdac3 CKO Mice Gene Symbol Fold Change PLoS ONE | www.plosone.org 4 July 2010 | Volume 5 | Issue 7 | e11492