Hdac3 Regulates Bone Density Figure 6. Trabecular bone formation rates are lower in Hdac3 CKO mice. A Fluorochrome incorporation in the trabeculi of distal femurs is decreased in CKO mice. Newly formed trabecular bone in distal femurs (B–G) and vertebrae (H–M) was assessed in 5.5 week old male mice following two calcein injections using OsteometricsTM software. (n = 5), *p,0.05, **p#0.01. doi:10.1371/journal.pone.0011492.g006 PLoS ONE | www.plosone.org 9 July 2010 | Volume 5 | Issue 7 | e11492