S-Aspirin Protects Aspirin-Induced Gastric Injury Figure 2. Effect of ACS14 on Asp-induced gastric mucosal injury in rats. ACS14 (1, 5 or 10 mg/kg) was given (i.p.) 30 min before intragastric administration of Asp (200 mg/kg). Representative photographs (A) and group data (B) showing ACS14 significantly attenuated Asp-induced gastric mucosal injury. Data are presented as means 6 SE. n = 8. *P,0.05 compared with control; #P,0.05 compared with Asp; {P,0.05 compared with Asp+ACS14 1 mg/kg. doi:10.1371/journal.pone.0046301.g002 PLOS ONE | www.plosone.org 4 September 2012 | Volume 7 | Issue 9 | e46301