NAC Inhibits Va14iNKT Cell Activation Figure 3. NAC therapy ameliorates agonistic Fas mAb-induced FLF during IFN-c deficiency. (a) Serum ALT levels in WT and IFN-c2/2 mice after PBS or NAC treatment during agonistic Fas mAb-induced FLF. (b) H & E staining of liver sections of WT and IFN-c2/2 mice after PBS or NAC treatment during agonistic Fas mAb-induced FLF. As shown in top panel, livers from Fas mAb-treated WT and IFN-c2/2 mice displayed widespread hepatocyte damage including hemorrhagic necrosis (white arrows) and apoptosis (black arrows) that distorted normal liver architecture. In contrast, liver sections of WT and IFN-c2/2 mice treated with NAC during Fas mAb-induced FLF (bottom panel) showed reduced hepatocyte damage and PLoS ONE | www.plosone.org 7 June 2012 | Volume 7 | Issue 6 | e38051