Hypoxia Potentiates Glioma Immunosuppression Figure 6. Inhibition of pSTAT3 and HIF-1a reverses hypoxia-gCSCs induced immunosuppression A. WP1066 reverses gCSC-mediated immunosuppression in human T cells to a greater degree than WP744. When healthy donor PBMCs were cultured in the presence of each of the supernatants conditioned by the gCSCs, T cell proliferation was inhibited, as demonstrated by FACS analysis on CFSE labeled T cell division. This PLoS ONE | www.plosone.org 10 January 2011 | Volume 6 | Issue 1 | e16195