Hdac3 Regulates Bone Density Figure 9. Hdac3 depletion alters multiple signaling pathways. A. GeneGo pathway analysis of genes differentially regulated in Hdac3-deficient calvarial osteoblasts. Data from two independent microarray experiments were analyzed with MetaCore software at a false discovery rate = 0.25. B. Model for defective osteoblast differentiation and increased adipocyte formation in Hdac3-insufficient mice. doi:10.1371/journal.pone.0011492.g009 PLoS ONE | www.plosone.org 12 July 2010 | Volume 5 | Issue 7 | e11492