MiR-338-3p on HBx Deletion Mutants (HBx-d382) Figure 5. miR-338-3p influence the colony formation of transfected LO2 cells. (A–B) Gain of miR-338-3p decreases the rate of colony formation of LO2/HBx-d382 and LO2/HBx cells, whereas loss of miR-338-3p enhances the non-anchored growing ability in HBx-expressing cells (*P,0.001, **P,0.01). (C) The non-anchored growing ability of control LO2/pcDNA3.0 cells are also inhibited by miR-338-3p, although the significant difference is lower than that in HBx-expressing cells (***P = 0.032,#P = 0.025). doi:10.1371/journal.pone.0043204.g005 PLOS ONE | www.plosone.org 9 August 2012 | Volume 7 | Issue 8 | e43204