References 1. Stasi R, Evangelista ML, Stipa E, Buccisano F, Venditti A, et al. (2008) Idiopathic thrombocytopenic purpura: current concepts in pathophysiology and management. Thromb Haemost 99: 4–13. 2. Semple JW, Milev Y, Cosgrave D, Mody M, Hornstein A, et al. (1996) Differences in serum cytokine levels in acute and chronic autoimmune thrombocytopenic purpura: relationship to platelet phenotype and antiplatelet T-cell reactivity. Blood 87: 4245–4254. 3. Sakakura M, Wada H, Tawara I, Nobori T, Sugiyama T, et al. (2007) Reduced Cd4+Cd25+ T cells in patients with idiopathic thrombocytopenic purpura. Thromb Res 120: 187–193. 4. Olsson B, Andersson PO, Jerna˚s M, Jacobsson S, Carlsson B, et al. (2003) T-cell- mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nat Med 9: 1123–1124. 5. Chow L, Aslam R, Speck ER, Kim M, Cridland N, et al. (2010) A murine model of severe immune thrombocytopenia is induced by antibody- and CD82 T cell– mediated responses that are differentially sensitive to therapy. Blood 115: 1247–1253. 6. Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, et al. (2005) Interleukin 17-producing CD4(+) effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6: 1123–1132. 7. Huber M, Heink S, Grothe H, Guralnik A, Reinhard K, et al. (2009) A Th17- like developmental process leads to CD8+ Tc17 cells with reduced cytotoxic activity. Eur J Immunol 39: 1716–1725. 8. Ma DX, Zhu XJ, Zhao P, Zhao CH, Li XF, et al. (2008) Profile of Th17 cytokines (IL-17, TGF-beta, IL-6) and Th1 cytokine (IFN-gamma) in patients with immune thrombocytopenic purpura. Ann Hematol 87: 899–904. 9. Zhang JB, Ma DX, Zhu XJ, Qu X, Ji CY, et al. (2009) Elevated profile of Th17, Th1 and Tc1 cells in patients with immune thrombocytopenic purpura. Haematologica 94: 1326–1329. 10. Zhu XJ, Ma DX, Zhang JB, Peng J, Qu X, et al. (2010) Elevated interleukin-21 correlated to Th17 and Th1 cells in patients with immune thrombocytopenia. J Clin Immunol 30: 253–259. 11. Hamada H, Garcia-Hernandez MdeL, Reome JB, Misra SK, Strutt TM, et al. (2009) Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge. J Immunol 182: 3469–3481. 12. Garcia-Hernandez MdeL, Hamada H, Reome JB, Misra SK, Tighe MP, et al. (2010) Adoptive transfer of tumor-specific Tc17 effector T cells controls the growth of B16 melanoma in mice. J Immunol 184: 4215–4227. 13. Zhao XY, Xu LL, Lu SY, Huang XJ (2011) IL-17-producing T cells contribute to acute graft-versus-host disease in patients undergoing unmanipulated blood and marrow transplantation. Eur J Immunol 41: 514–526. 14. Res PCM, Piskin G, Boer OJde, van der Loos CM, Teeling P, et al. (2010) Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional Tc17 in ITP skin suggests their involvement in the pathogenesis of psoriasis. PLoS ONE. 5e14108. 15. Henriques A, Ineˆs L, Couto M, Pedreiro S, Santos C, et al. (2010) Paiva, Frequency and functional activity of Th17, Tc17 and other T-cell subsets in systemic lupus erythematosus. Cell Immunol 264: 97–103. 16. Rodeghiero F, Stasi R, Gernsheimer T, Michel M, Provan D, et al. (2009) Standardization of terminology, definitions and outcome criteria in immune thrombocytopenia of adults and children: report from an international working group. Blood 113: 2386–2393. 17. Hou M, Peng J, Shi Y, Zhang C, Qin P, et al. (2003) Mycophenolate mofetil (MMF) for the treatment of steroid-resistant idiopathic thrombocytopenic purpura. Eur J Haematol 70: 353–357. 18. Semple JW (2002) Immune pathophysiology of autoimmune thrombocytopenic purpura. Blood Rev 16: 9–12. 19. Chi LJ, Xu WH, Zhang ZW, Huang HT, Zhang LM, et al. (2010) Distribution of Th17 cells and Th1 cells in peripheral blood and cerebrospinal fluid in chronic inflammatory demyelinating polyradiculoneuropathy. J Peripher Nerv Syst 15: 345–356. 20. Kagami SJ, Rizzo HL, Lee JJ, Koguchi Y, Blauvelt A (2010) Circulating Th17, Th22, and Th1 cells are increased in psoriasis. J Invest Dermatol 130: 1373–1383. 21. Kondo T, Takata H, Matsuki F, Takiguchi M (2009) Cutting edge: phenotypic characterization and differentiation of human CD8+ T cells producing IL-17. J Immunol 182: 1794–1798. 22. Zhao Y, Balato A, Fishelevich R, Chapoval A, Mann DL, et al. (2009) Th17/ Tc17 infiltration and associated cytokine gene expression in elicitation phase of allergic contact dermatitis. Br J Dermatol 29: 1301–1306. 23. Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, et al. (2007) IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 8: 967–974. 24. Yang XO, Pappu BP, Nurieva R, Akimzhanov A, Kang HS, et al. (2008) T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity 28: 29–39. 25. Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, et al. (2006) The orphan nuclear receptor ROR gamma t directs the differentiation program of pro-inflammatory IL-171 T helper cells. Cell 126: 1121–1133. 26. Nicoletti F, Lamenta C, Donati S, Spada M, Ranazzi A, et al. (2008) Inhibition of human immunodeficiency virus (HIV-1) infection in human peripheral blood leucocytes-SCID reconstituted mice by rapamycin. Clin Exp Immunol 155: 28–34. 27. Syrjala H, Surcel HM, Ilonen J (1991) Low CD4/CD8 T lymphocyte ratio in acute myocardial infarction. Clin Exp Immunol 83: 326–328. PLoS ONE | www.plosone.org 7 October 2011 | Volume 6 | Issue 10 | e26522