32. Chambers RC, Dabbagh K, McAnulty RJ, Gray AJ, Blanc-Brude OP, et al. (1998) Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1. Biochem J 333(Pt 1): 121–127. 33. Brousseau C, Morissette G, Fortin JP, Marceau F, Petitclerc E (2009) Tumor cells expressing tissue factor influence the migration of smooth muscle cells in a catalytic activity-dependent way. Canadian journal of physiology and pharma- cology 87: 694–701. 34. O’Brien PJ, Prevost N, Molino M, Hollinger MK, Woolkalis MJ, et al. (2000) Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1. The Journal of biological chemistry 275: 13502–13509. 35. Shi X, Gangadharan B, Brass LF, Ruf W, Mueller BM (2004) Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis. Molecular cancer research : MCR 2: 395–402. 36. Nakanishi-Matsui M, Zheng YW, Sulciner DJ, Weiss EJ, Ludeman MJ, et al. (2000) PAR3 is a cofactor for PAR4 activation by thrombin. Nature 404: 609–613. 37. Deng X, Mercer PF, Scotton CJ, Gilchrist A, Chambers RC (2008) Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho kinase signaling pathways. Mol Biol Cell 19: 2520–2533. 38. Ostrowska E, Reiser G (2008) Protease-activated receptor (PAR)-induced interleukin-8 production in airway epithelial cells requires activation of MAP kinases p44/42 and JNK. Biochem Biophys Res Commun 366: 1030–1035. 39. Wang L, Luo J, Fu Y, He S (2006) Induction of interleukin-8 secretion and activation of ERK1/2, p38 MAPK signaling pathways by thrombin in dermal fibroblasts. Int J Biochem Cell Biol 38: 1571–1583. 40. Pao LI, Sumaria N, Kelly JM, van Dommelen S, Cretney E, et al. (2005) Functional analysis of granzyme M and its role in immunity to infection. J Immunol 175: 3235–3243. 41. Pardo J, Simon MM, Froelich CJ (2009) Granzyme A is a proinflammatory protease. Blood 114: 3968; author reply 3969–3970. 42. Ludwicka-Bradley A, Tourkina E, Suzuki S, Tyson E, Bonner M, et al. (2000) Thrombin upregulates interleukin-8 in lung fibroblasts via cleavage of Granzyme K Activates PAR-1 proteolytically activated receptor-I and protein kinase C-gamma activation. Am J Respir Cell Mol Biol 22: 235–243. 43. Akira S, Kishimoto T (1992) IL-6 and NF-IL6 in acute-phase response and viral infection. Immunol Rev 127: 25–50. 44. Akira S, Kishimoto T (1996) Role of interleukin-6 in macrophage function. Curr Opin Hematol 3: 87–93. 45. Ge S, Pachter JS (2004) Caveolin-1 knockdown by small interfering RNA suppresses responses to the chemokine monocyte chemoattractant protein-1 by human astrocytes. J Biol Chem 279: 6688–6695. 46. Gharaee-Kermani M, Denholm EM, Phan SH (1996) Costimulation of fibroblast collagen and transforming growth factor beta1 gene expression by monocyte chemoattractant protein-1 via specific receptors. J Biol Chem 271: 17779–17784. 47. Moore BB, Kolodsick JE, Thannickal VJ, Cooke K, Moore TA, et al. (2005) CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury. The American journal of pathology 166: 675–684. 48. Moore BB, Peters-Golden M, Christensen PJ, Lama V, Kuziel WA, et al. (2003) Alveolar epithelial cell inhibition of fibroblast proliferation is regulated by MCP- 1/CCR2 and mediated by PGE2. American journal of physiology Lung cellular and molecular physiology 284: L342–349. 49. Georganas C, Liu H, Perlman H, Hoffmann A, Thimmapaya B, et al. (2000) Regulation of IL-6 and IL-8 expression in rheumatoid arthritis synovial fibroblasts: the dominant role for NF-kappa B but not C/EBP beta or c-Jun. J Immunol 165: 7199–7206. 50. Moore BB, Kolodsick JE, Thannickal VJ, Cooke K, Moore TA, et al. (2005) CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury. Am J Pathol 166: 675–684. 51. Suga M, Iyonaga K, Ichiyasu H, Saita N, Yamasaki H, et al. (1999) Clinical significance of MCP-1 levels in BALF and serum in patients with interstitial lung diseases. Eur Respir J 14: 376–382. 52. Shinoda H, Tasaka S, Fujishima S, Yamasawa W, Miyamoto K, et al. (2009) Elevated CC chemokine level in bronchoalveolar lavage fluid is predictive of a poor outcome of idiopathic pulmonary fibrosis. Respiration; international review of thoracic diseases 78: 285–292. PLoS ONE | www.plosone.org 9 June 2011 | Volume 6 | Issue 6 | e21484