Breast Cancer Degradomic View Figure 3. The net cleavage specificity of BCP and HP proteases for the degradome-wide substrates. The cleavage positions P and P9 defined by Schechter I. and Berger A. (Papain Biochem Biophys Res Commun 1967, 27: 157–162) are adopted herein to present the specificity measured from ,1000 peptidome peptides listed in Table S2. doi:10.1371/journal.pone.0013133.g003 Analysis of degradomic profiles for different stages of breast cancer, breast benign tumors and different molecular subgroups of breast cancers, and other types of cancers (e.g., uterine, liver, lung cancers, etc) and diseases (e.g., inflammation) are needed for statistical validation of which aberrances of the degradomic profile and/or which substrate sequence domains generating the peptidome peptides are specific to or unique for BCP before the BCP degradomic profile and/or individual peptidomic peptides PLoS ONE | www.plosone.org 5 October 2010 | Volume 5 | Issue 10 | e13133