Etanercept Prevents Glaucomatous Neurodegeneration Figure 3. Activation of microglia in the vitreal surface of the optic nerve head (ONH). A, Iba-l positive microglia in sham-operated control eyes are ramified and quiescent and exhibit a mosaic arrangement around ONH. B, Increased number of activated microglia with short, broad processes 5 days after OHT induction. C, Decreased number of active microglia around the ONH with Etanercept treatment. D, Bar graph indicating the number of stage 3 and 4 Iba-1 positive microglia/mm2. Mann-Whitney U test, **P,0.01 comparing sham-operated control and OHT cases treated PLoS ONE | www.plosone.org 4 July 2012 | Volume 7 | Issue 7 | e40065