GAT: Graph Analysis Toolbox for Brain Networks Figure 7. Between-group differences in regional network topology. Regions that showed significant between-group differences in nodal betweenness mapped on ICBM152 surface template. Hot color identifies the regions that have significantly higher nodal betweenness in CON compared to ALL while cold color identifies regions with significantly higher nodal betweenness in ALL compared to CON. The regional differences were quantified based on AUC analysis in the density range of 0.22:0.01:0.45. doi:10.1371/journal.pone.0040709.g007 Figure 8. Network hubs.: Constructed networks and corresponding hubs for ALL (top) and CON (middle) groups. Nodes that are labeled represent network hubs (nodes with nodal betweenness of 2SD greater than network mean betweenness). The volume of the spheres represents the betweenness of the corresponding brain region. Green color highlights hubs specific to CON network; yellow color represents hubs specific to ALL network; Orange color represents hubs that are common in both groups; blue color represents non-hub regions. The hubs were quantified based on AUC analysis in the density range of 0.22:0.01:0.45. doi:10.1371/journal.pone.0040709.g008 PLoS ONE | www.plosone.org 11 July 2012 | Volume 7 | Issue 7 | e40709