PPARc Ligands Differentially Impact OVCAR Cells Figure 3. Effect of TZD treatment on Ovcar3, CaOv3 and Skov3 cell proliferation. Ovarian cancer cells were serum starved for 24 hours and treated for an additional 24 hours with vehicle control (DMSO) or 0.1, 1.0 or 10 mM of CGZ (A), TGZ (B), Rosi (C), or Pio (D). Cell proliferation was assessed with the MTS assay. Results are the means 6 SEM for at least 3 measurements from three individual experiments. Statistical analysis was performed within each cell line. Bars that do not share a letter designation are significantly different within a treatment group (p,0.05). Black bars: Ovcar3, Grey: CaOv3, Light grey: Skov3. doi:10.1371/journal.pone.0016179.g003 PLoS ONE | www.plosone.org 5 January 2011 | Volume 6 | Issue 1 | e16179