IL-17 and Synoviocyte Survival Figure 1. Effect of IL-17 on synoviolin expression in RA FLS. RA FLS were stimulated with IL-17A or IL-17F (50 ng/ml), IL-1 10 ng/ml, TNF 10 ng/ml or LPS 100 ng/ml for 24 h and synoviolin mRNA expression measured by real-time RT-PCR (A, upper panel). The results based on a ratio of synoviolin/b-actin mRNA amplification are presented as the fold induction in synoviolin mRNA expression relative to control samples, n = 3, mean 6 PLoS ONE | www.plosone.org 3 October 2010 | Volume 5 | Issue 10 | e13416