Breast Cancer Degradomic View Figure 7. Degradation of complement system convertases observed for the tested BCP. (A) For C3, the degradation was solely on the C3d, C3g, C3a91 and C3b (black color-filled ovals), not on the other fragments (blank-filled ovals); the C3 sequence domains are colored for comparison of the domains observed with degradation. (B) For C4, the degradation was solely on the C4b and C4b (black color-filled ovals), not on the other fragments (blank-filled ovals); the degradation of the front portion of the C4b fragment was observed solely for the tested BCP. (C) For complement factor B, the degradation was solely on the complement factor Ba and Bb (black color-filled ovals), not on the other fragments (blank-filled ovals). The red, blue, and black lines along the amino acid sequences represent the peptidome peptides identified solely from the tested BCP, HP, and both the BCP and HP, respectively. doi:10.1371/journal.pone.0013133.g007 PLoS ONE | www.plosone.org 9 October 2010 | Volume 5 | Issue 10 | e13133