breakpoints are distal to ACCN1, and it has been suggested that the 17q12 region might contain a gene that suppresses neuroblastoma [44]. These data warrant further investigation into the role of ACCN1 in neuroblastoma. Additionally, it remains possible that the translocation analyzed here affects an unidentified gene in the ACCN1 intron in which the translocation breakpoint lies. In this region we observed two putative promoter sequences, as predicted by FirstEF [45], and a small number of ESTs not annotated to a known gene and devoid of a meaningful open reading frame (data not shown). It is not clear whether these sequences have a function or are merely the result of random transcriptional activation. In conclusion, we describe the molecular cloning of both translocation breakpoints in a neuroblastoma patient with a constitutional t(1;17) translocation. Genes overlapping both References 1. Brodeur GM (2003) Neuroblastoma: biological insights into a clinical enigma. 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