Resting State Networks Awake Rats Figure 1. Awake Rat Motion Assessment. The motion parameters for 2 typical rats (Left column) in the study and the 2 rejected rats (Right column) are displayed. Green Line, translation/rotation X-axis, Blue Y-axis, and Red Z-axis. doi:10.1371/journal.pone.0025701.g001 excludes the cingulate cortex. A similar network has been reported in rats by Zhang et al. [26]. Component 7 - Interoceptive Network. This network includes sensory cortices as described in component 6 as well as secondary visual structures and the insular and cingulate cortices (Table S7 and Figure 2-C7). Components 8–20. These components did not achieve statistical significance for robustness and reproducibility at the 90% confidence level. Inspection of them revealed that some were artifacts (9, 13, and 20 involved ventricles); 14 captured some edge of the brain; 15–19 networks seemed to already appear as part of statistically significant components. Only networks #8 and 10 reflected some biological relevant structures (CPu and cingulate/ cortical ribbon, respectively). Please see Figures S2 and S3 for maps of components 8–20. Discussion Here we report 7 resting state networks of a model of awake rats that are robust and reproducible. These networks were chosen PLoS ONE | www.plosone.org 4 October 2011 | Volume 6 | Issue 10 | e25701