Neuroblastoma Breakpoint 40. Vila-Carriles WH, Kovacs GG, Jovov B, Zhou ZH, Pahwa AK, et al. (2006) Surface expression of ASIC2 inhibits the amiloride-sensitive current and migration of glioma cells. J Biol Chem 281: 19220–19232. 41. Hiyama E, Hiyama K, Nishiyama M, Reynolds CP, Shay JW, et al. (2003) Differential gene expression profiles between neuroblastomas with high telomerase activity and low telomerase activity. J Pediatr Surg 38: 1730–1734. 42. Ettaiche M, Guy N, Hofman P, Lazdunski M, Waldmann R (2004) Acid-sensing ion channel 2 is important for retinal function and protects against light-induced retinal degeneration. J Neurosci 24: 1005–1012. 43. Vandesompele J, Baudis M, De Preter K, Van Roy N, Ambros P, et al. (2005) Unequivocal delineation of clinicogenetic subgroups and development of a new model for improved outcome prediction in neuroblastoma. J Clin Onc 23: 2280–2299. 44. Lastowska M, Cotterill S, Bown N, Cullinane C, Variend S, et al. (2002) Breakpoint position on 17q identifies the most aggressive neuroblastoma tumors. Gene Chromosome Canc 34: 428–436. 45. Davuluri RV, Grosse I, Zhang MQ (2001) Computational identification of promoters and first exons in the human genome. Nat Genet 29: 412–417. PLoS ONE | www.plosone.org 12 May 2008 | Volume 3 | Issue 5 | e2207