40. Lin J, Gan CM, Zhang X, Jones S, Sjoblom T, et al. (2007) A multidimensional analysis of genes mutated in breast and colorectal cancers. Genome Res 17: 1304–1318. 41. Ghobrial IM, Witzig TE, Adjei AA (2005) Targeting apoptosis pathways in cancer therapy. CA Cancer J Clin 55: 178–194. 42. Rizzo P, Osipo C, Foreman K, Golde T, Osborne B, et al. (2008) Rational targeting of Notch signaling in cancer. Oncogene 27: 5124–5131. 43. McConnell JL, Gomez RJ, McCorvey LR, Law BK, Wadzinski BE (2007) Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway. Oncogene 26: 6021–6030. 44. Chou WC, Wang HC, Wong FH, Ding SL, Wu PE, et al. (2008) Chk2- dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair. Embo J 27: 3140–3150. 45. Zhao Y, Katzman RB, Delmolino LM, Bhat I, Zhang Y, et al. (2007) The notch regulator MAML1 interacts with p53 and functions as a coactivator. J Biol Chem 282: 11969–11981. 46. Langie SA, Knaapen AM, Houben JM, van Kempen FC, de Hoon JP, et al. (2007) The role of glutathione in the regulation of nucleotide excision repair during oxidative stress. Toxicol Lett 168: 302–309. Damage Survival Pathways 47. Jelinsky SA, Estep P, Church GM, Samson LD (2000) Regulatory networks revealed by transcriptional profiling of damaged Saccharomyces cerevisiae cells: Rpn4 links base excision repair with proteasomes. Mol Cell Biol 20: 8157–8167. 48. Barlow C, Hirotsune S, Paylor R, Liyanage M, Eckhaus M, et al. (1996) Atm- deficient mice: a paradigm of ataxia telangiectasia. Cell 86: 159–171. 49. Boutros M, Kiger AA, Armknecht S, Kerr K, Hild M, et al. (2004) Genome- wide RNAi analysis of growth and viability in Drosophila cells. Science 303: 832–835. 50. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(2Delta Delta C(T)) Method. Methods 25: 402–408. 51. Costa LdF, Rodrigues FA, Travieso G, Boas PRV (2007) Characterization of complex networks: A survey of measurements. Advances in Physics 56: 167–242. 52. Sokal RR, Rohlf FJ (1969) Biometrics. San Francisco: W. H. Freeman. pp 575–585. 53. Fisher R (1922) On the interpretation of x2 from contingency tables, and the calculation of P. Journal of the Royal Statistical Society 85: 87–94. PLoS Genetics | www.plosgenetics.org 18 June 2009 | Volume 5 | Issue 6 | e1000527