45. Barbuti A, Galvez BG, Crespi A, Scavone A, Baruscotti M, et al. (2010) Mesoangioblasts from ventricular vessels can differentiate in vitro into cardiac myocytes with sinoatrial-like properties. J Mol Cell Cardiol 48: 415–423. 46. Kurpinski K, Lam H, Chu J, Wang A, Kim A, et al. (2010) Transforming growth factor-beta and notch signaling mediate stem cell differentiation into smooth muscle cells. Stem Cells 28: 734–742. S1P Differentiates Mesoangioblasts 47. Krenning G, Moonen JR, van Luyn MJ, Harmsen MC (2008) Generating new blood flow: integrating developmental biology and tissue engineering. Trends Cardiovasc Med 18: 312–323. PLoS ONE | www.plosone.org 11 May 2011 | Volume 6 | Issue 5 | e20389