PLD1 Regulation by AMPK 39. Chen HC, Bandyopadhay G, Sajan MP, Kanoh Y, Standaert ML, et al. (2002) Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stim- ulated glucose transport. J Biol Chem 277: 23554–23562. 40. Park JB, Kim JH, Kim Y, Ha SH, Yoo JS, et al. (2000) Cardiac phospholipase D2 localizes to sarcolemmal membranes and is inhibited by alpha-actinin in an ADP-ribosylation factor-reversible manner. J Biol Chem 275: 21295–21301. 41. Kim JH, Kim JH, Ohba M, Suh PG, Ryu SH (2005) Novel functions of the phospholipase D2-Phox homology domain in protein kinase Czeta activation. Mol Cell Biol 25: 3194–3208. 42. Kim JH, Lee S, Kim JH, Lee TG, Hirata M, et al. (2002) Phospholipase D2 directly interacts with aldolase via Its PH domain. Biochemistry 41: 3414–3421. 43. Marsin AS, Bertrand L, Rider MH, Deprez J, Beauloye C, et al. (2000) Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia. Curr Biol 10: 1247–1255. 44. Wang Q, Khayat Z, Kishi K, Ebina Y, Klip A (1998) GLUT4 translocation by insulin in intact muscle cells: detection by a fast and quantitative assay. FEBS Lett 427: 193–197. 45. Kim JH, Kim HW, Jeon H, Suh PG, Ryu SH (2006) Phospholipase D1 regulates cell migration in a lipase activity-independent manner. J Biol Chem 281: 15747–15756. PLoS ONE | www.plosone.org 13 March 2010 | Volume 5 | Issue 3 | e9600