Video S1 Mitochondrial structure changes following Myc deactivation in MycER cells. MycER cells were observed under live confocal microscopy either prior to (left) or 24 h after the removal of 4-HT. Mitochondria were stained with MitoTracker Deep Red and 3-dimensional reconstructions of the cells were performed from a series of z-stacks. Note the loss of total mitochondria and the decrease in interconnectivity upon removal of 4-HT. Furthermore, note the preferential loss of perinuclear mitochondria. (MOV) References 1. Nesbit CE, Tersak JM, Prochownik EV (1999) MYC oncogenes and human neoplastic disease. Oncogene 18: 3004–3016. 2. Meyer N, Penn LZ (2008) Reflecting on 25 years with MYC. Nat Rev Cancer 8: 976–990. 3. Prochownik EV (2008) c-Myc: linking transformation and genomic instability. Curr Mol Med 8: 446–458. 4. Dang CV, O’Donnell KA, Zeller KI, Nguyen T, Osthus RC, et al. (2006) The c- Myc target gene network. Semin Cancer Biol 16: 253–264. 5. 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