Page 5 of 13 Alteration frequency (n=40) Gene numberd Lo et al. BMC Cancer 2012, 12:235 http://www.biomedcentral.com/1471-2407/12/235 Table 1 Chromosome imbalance regions in lung cancer (alteration frequency > 50%) Chromosome Cytobanda Start siteb End siteb Size BAC (Mb)c number A. Asian 3 p13-14.1* 64934270 73536726 8.60 74 Gain: 73% 23 6 p22.1* 26562439 28452189 1.89 60 Gain: 70% 31 9 q21.13* 73445866 76242707 2.80 29 Gain: 70% 8 10 q21.3 69354590 71006065 1.65 15 Gain: 55% 23 10 q24.1 95664566 99431796 3.77 37 Gain: 58% 44 12 p13.31-13.32 2363194 8268165 5.90 44 Gain: 60% 58 13 q14.1-14.2* 42340030 47097431 4.76 38 Gain: 80% 22 17 p13.3* 373082 2754327 2.38 20 Gain: 60% 37 2 p23.2-23.3 25035233 33995335 8.96 75 Loss: 63% 83 2 p24.1 21212355 23783250 2.57 18 Loss: 58% 1 2 q35 215083214 215870969 0.79 9 Loss: 58% 5 3 p21.3-22.3* 33902686 44181635 10.28 82 Loss: 65% 90 4 p15.2-15.31 22255381 24549727 2.29 24 Loss: 60% 5 6 p22.2 23982002 25939112 1.96 68 Loss: 80% 16 12 q15 67646357 69188647 1.54 11 Loss: 55% 11 13 q13.3* 35856763 39003721 3.15 27 Loss: 65% 18 X p22.31 5701499 5872842 0.17 2 Loss: 50% 1 Overall 476 B. Caucasian 2 p24.1-24.3 12723105 21045423 8.32 58 Gain: 55% 21 2 q25.1 11704089 12544967 0.84 7 Gain: 50% 2 3 p12.3-13* 67690502 79574641 11.88 96 Gain: 70% 22 3 p14.1-14.3* 56804094 67550231 10.75 65 Gain: 50% 26 3 p21.31-22.1 42559388 46459596 3.90 33 Gain: 60% 57 3 p25.3-26.3 1711179 9591700 7.88 72 Gain: 55% 20 6 p22.1-22.3* 20951128 28567815 7.62 132 Gain: 60% 97 9 q21.13* 75834015 76513536 0.68 6 Gain: 70% 5 13 q14.1-14.2* 40944092 47097431 6.15 47 Gain: 80% 24 17 p13.2-13.3* 481074 4001084 3.52 13 Gain: 70% 35 X p22.11-22.2 16180300 22691476 6.51 49 Gain: 60% 26 2 p22.3 32854381 33890229 1.04 6 Loss: 50% 3 2 p24.3-25.1 31026798 31813698 0.79 6 Loss: 50% 3 3 p11.1-12.1 84572959 90247330 5.67 46 Loss: 70% 9 3 p22.2-22.3* 32980614 36795763 3.82 13 Loss: 75% 14 3 p23 31259835 32891762 1.63 13 Loss: 60% 10 6 p21.2-22.1 29049491 39602226 10.55 86 Loss: 70% 27 10 p23.1-23.2 82106537 89500949 7.39 79 Loss: 60% 36 12 p12.31 8090287 9190860 1.10 7 Loss: 50% 18 13 q13.3* 35856763 36315193 0.46 5 Loss: 80% 4 Overall 459 a The common alteration regions in both Asian and Caucasian are marked with asterisk (*). b The information of cytoband start site and end site nucleotide sequences were from UCSC database (http://genome.ucsc.edu/, build 36 - hg18). c The sizes of cytoband were calculated from the start site to the end site nucleotide sequences. d The gene number of candidate genes was estimated by “NimbleGen: Transcription_Start_Sites.gff” annotation file (Roche, Palo Alto, CA). The annotation file indicates all transcription initiation sites for build hg18 as reported in the UCSC Genome browser.