BMC Cancer 2006, 6:2 http://www.biomedcentral.com/1471-2407/6/2 4. Weremowicz S, Kupsky WJ, Morton CC, Fletcher JA: Cytogenetic evidence for a chromosome 22 tumor suppressor gene in ependymoma. Cancer Genet Cytogenet 1992, 61:193-196. 5. Arslantas A, Artan S, Oner U, Muslumanoglu H, Durmaz R, Cosan E, Atasoy MA, Basaran N, Tel E: The importance of genomic copy number changes in the prognosis of glioblastoma multi- forme. Neurosurg Rev 2004, 27:58-64. 6. Lang FF, Miller DC, Koslow M, Newcomb EW: Pathways leading to glioblastoma multiforme: a molecular analysis of genetic alterations in 65 astrocytic tumors. J Neurosurg 1994, 81:427-436. 7. Schlegel J, Scherthan H, Arens N, Stumm G, Kiessling M: Detection of complex genetic alterations in human glioblastoma multi- forme using comparative genomic hybridization. J Neuropath Exper Neurol 1996, 55:81-87. 8. Scheck AC, Mehta BM, Beikman MK, Shapiro JR: BCNU-resistant human glioma cells with over-representation of chromo- somes 7 and 22 demonstrate increased copy number and expression of platelet-derived growth factor genes. Genes, Chromosomes & Cancer 1993, 8:137-148. 9. Scheck AC, Shapiro JR, Ballacer C, Kohlke E, Rhodes SN, Sinnott HA, Norman SA, Bohnert A: Clonal analysis of human malignant gli- oma cells selected for resistance to BCNU [abstract]. Pro- ceedings of the American Association for Cancer Research 1996, 37:338. 10. Scheck AC, Mehta BM, Beikman MK, Shapiro JR: BCNU-resistant human glioma cells with over-representation of chromo- somes 7 and 22 demonstrate increased copy number and expression of platelet-derived growth factor genes. Genes, Chromosomes & Cancer 1993, 8:137-148. 11. Asch AS, Leung LLK, Shapiro JR, Nachman RL: Human brain glial cells synthesize thrombospondin. Proc Natl Acad Sci USA 1986, 83:2904-2908. 12. Norman SA, Rhodes SN, Treasurywala S, Hoelzinger DB, Shapiro JR, Scheck AC: Identification of transforming growth factor- beta1 binding protein over-expression in BCNU-resistant glioma cells by differential mRNA display. Cancer 2000, 89:850-862. 13. Shapiro JR, Yung W-KA, Shapiro WR: Isolation, karyotype, and clonal growth of heterogeneous subpopulations of human malignant gliomas. Cancer Res 1981, 41:2349-2359. 14. Bangs CD, Donlon TA: Cytogenetics. In Current Protocols in Human Genetics Edited by: Dracopoli NC, Haines JL, Korf BR, Moir DT, Mor- ton CC, Seidman JG, Smith DR. New York: John Wiley & Sons; 2000:4.1-4.12.7. 15. An International System for Human Cytogenetic Nomenclature Basel: Pub- lished in collaboration with Cytogenet Cell Genet. (Suppl), Karger; 1985. 16. Guidelines for cancer cytogenetics. Supplement to an international system for human genetic nomenclature New York: S. Karger; 1991. 17. Dunham I, Dewar K, Kim U-J, Ross MT: Bacterial Cloning Sys- tems. In Volume 3/Cloning Systems Volume 3. Edited by: Birren B, Green ED, Klapholz S, Myers RM, Riethman H, Roskams J. Plainview, N.Y.: Cold Spring Harbor Laboratory Press; 1999:1-87. 18. Shapiro JR, Scheck AC: Brain tumors. In Cytogenetic markers of human cancer Edited by: Wolman SR, Sell S. New Jersey: The Humana Press, Inc; 1997:319-368. 19. Claesson-Welsh L, Eriksson A, Morën A, Severinsson L, Ek B, Ostman A, Betsholtz C, Heldin CH: cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor spe- cific for B-chain-containing PDGF molecules. Mol Cell Biol 1988, 8:3476-3486. 20. Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, Labourier E, Reinert KL, Brown D, Slack FJ: RAS is regulated by the let-7 microRNA family. Cell 2005, 120:635-647. 21. Sempere LF, Freemantle S, Pitha-Rowe I, Moss E, Dmitrovsky E, Ambros V: Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possi- ble roles in murine and human neuronal differentiation. Genome Biol 2004, 5:R13. Pre-publication history The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2407/6/2/prepub Publish with Bio Med Central and every scientist can read your work free of charge "BioMed Central will be the most significant development for disseminating the results of biomedical research in our lifetime." Sir Paul Nurse, Cancer Research UK Your research papers will be: available free of charge to the entire biomedical community peer reviewed and published immediately upon acceptance cited in PubMed and archived on PubMed Central yours — you keep the copyright Submit your manuscript here: http://www.biomedcentral.com/info/publishing_adv.asp BioMedcentral Page 10 of 10 (page number not for citation purposes)