BMC Genomics 2008, 9:61 http://www.biomedcentral.com/1471-2164/9/61 Table 4: Predicted function and biological processes of uORF-mORF pairs in Drosophila CG identifier Gene name synonymsa Inferred functiona Inferred biological proc- essa Supporting evidence CG18624 Putative NADH Mitochondrial electron Pfam domain; GO term dehydrogenase transport designation CG12664 ld14, fendb Unknown Neuromuscular development [61, 62] CG12788/CG17767c Tim9bb (uORF) Mitochondrial inner Transport across Interpro domain membrane translocase subunit mitochondrial inner (uORF) membrane (uORF) CG33713/CG33714c Acyl-CoA binding (mORF) Unknown Interpro domain RNA binding (uORF) CG3240 Rad1b Putative 3'->5' exonuclease DNA repair [63, 64] activity CG9960/CG9958c snapin (uORF) Putative methyltransferase Biogenesis of lysosome- [65] (uORF) Interpro domain (mORF) Putative Biogenesis of related organelles (eg. (mORF) Lysosome-related Organelles melanosomes and platelet Complex-1-like (BLOC-1-like) dense granules; uORF) subunit (uORF) CG31917 TFB5 (uORF) Putative TFIIH subunit (uORF) Transcription and DNA [66, 67]; Interpro domain repair (uORF) CG31919/CG33995c Ankyrin repeat, protein- Target of transcription factor Interpro domain; [68] protein interactions Glial cells missing (Gcm), involved in neuronal development and function CG18042 lmgb Putative component of Mitosis; Neural development [69, 70]; Flybase personal Anaphase Promoting (unclear whether it is the communication FBrf0125046; Complex (uORF) uORF, mORF or both) [71]; NCBI Conserved Domain Search CG7400 Fatpb Putative very-long-chain fatty Fatty acid metabolism [72] acyl-CoA synthetase CG16974 Member of LIG superfamilyb Leucine-rich repeat and Unknown [73, 74] Immunoglobulin domain- containing protein CG4824 BicCb RNA binding protein Anterior-Posterior [75–77] patterning CG17325 Unknown Unknown CG10570 Unknown Unknown CG11508 DmSNAP50, DmPBP49b Subunit of an snRNA Transcription of splicing [78] transcriptional activator factors protein CG8026 Mitochondrial carrier protein Mitochondrial folate [37, 38] transport CG17759b (uORF2) Galpha49B, Gqα b G-protein subunit Photoreceptor signal [79–81] transduction; Axonal guidance CG33671/CG33672c Mevalonate kinase (mORF); Isoprenoid production [82, 83] BolA-like protein, putative (mORF) nucleic acid binding protein (uORF) CG6191 Unknown Unknown CG30100 Translation release factor Translation termination GO term designation CG17725 Pepckb Putative phosphoenolpyruvate Gluconeogenesis; Starvation; [84–86] carboxykinase Glyceroneogenesis CG5469 Gint3b Ubiquitin regulatory X domain Unknown [87]; FBrf0189302 (UBX), putative RNA binding CG33786/CG33785c Unknown Translation (mORF) Interpro domain Transcription (uORF) CG9865b (uORF1) Putative mannosyl transferase Unknown Interpro domain CG9865b (uORF2) Putative mannosyl transferase Unknown Interpro domain CG9865b (uORF3) Putative mannosyl transferase Unknown Interpro domain CG9878 Tim10b Putative inner mitochondrial Protein transport across [88] membrane translocase mitochondrial membrane CG30290 Putative flavoprotein enzyme Unknown Interpro domain CG12016 Unknown Unknown CG32573 Unknown Unkown Page 9 of 14 (page number not for citation purposes)