Bruera et al. BMC Cancer 2010, 10:567 http://www.biomedcentral.com/1471-2407/10/567 Table S2 describes preliminary data of activity, in the first step of the study (Simon’s two-step design). Supplemental Table S3 describes toxicities characterizing Limiting Toxicity Syndromes (LTS) in individual patients. Author details 1Medical Oncology, S. Salvatore Hospital, University of L’Aquila, L’Aquila, Italy. 2Medical Oncology, IDI, Rome, Italy. 3Medical Oncology, S. Andrea Hospital, University La Sapienza, Rome, Italy. 4General Surgery, S. Salvatore Hospital, L’Aquila, Italy. Authors’ contributions Study conception: ER. Study design: ER. Data acquisition: All authors. Data analysis and interpretation: GB, AS, KC, ER. Manuscript preparation: GB, AS. Final approval: All authors. Manuscript revising: GB, ER. Competing interests The authors declare that they have no competing interests. Received: 21 May 2010 Accepted: 19 October 2010 Published: 19 October 2010 References 1. 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