Cherrier et al. BMC Cancer 2010, 10:1 http://www.biomedcentral.com/1471-2407/10/1 11. Cherrier MM, Rose AL, Higano C: The effects of combined androgen blockade on cognitive function during the first cycle of intermittent androgen suppression in patients with prostate cancer. J Urol 2003, 170(5):1808-1811. 12. Salminen EK, Portin RI, Koskinen A, Helenius H, Nurmi M: Associations between serum testosterone fall and cognitive function in prostate cancer patients. Clin Cancer Res 2004, 10(22):7575-7582. 13. Epstein R, Kanwisher N: A cortical representation of the local visual environment. Nature 1998, 392(6676):598-601. 14. Hartley T, Maguire EA, Spiers HJ, Burgess N: The well-worn route and the path less traveled: distinct neural bases of route following and wayfinding in humans. Neuron 2003, 37(5):877-888. 15. Hayes SM, Ryan L, Schnyer DM, Nadel L: An fMRI study of episodic memory: retrieval of object, spatial, and temporal information. Behav Neurosci 2004, 118(5):885-896. 16. Halari R, Sharma T, Hines M, Andrew C, Simmons A, Kumari V: Comparable fMRI activity with differential behavioural performance on mental rotation and overt verbal fluency tasks in healthy men and women. Experimental brain research Experimentelle Hirnforschung 2006, 169(1):1-14. 17. Hugdahl K, Thomsen T, Ersland L: Sex differences in visuo-spatial processing: an fMRI study of mental rotation. Neuropsychologia 2006, 44(9):1575-1583. 18. Schoning S, Engelien A, Kugel H, Schafer S, Schiffbauer H, Zwitserlood P, Pletziger E, Beizai P, Kersting A, Ohrmann P, et al: Functional anatomy of visuo-spatial working memory during mental rotation is influenced by sex, menstrual cycle, and sex steroid hormones. Neuropsychologia 2007. 19. Sommer IE, Cohen-Kettenis PT, van Raalten T, Vd Veer AJ, Ramsey LE, Gooren LJ, Kahn RS, Ramsey NF: Effects of cross-sex hormones on cerebral activation during language and mental rotation: An fMRI study in transsexuals. Eur Neuropsychopharmacol 2008, 18(3):215-221. 20. Cherrier MM, Aubin S, Higano CS: Cognitive and Mood Changes in Men Undergoing Intermittent Combined Androgen Blockade for Non- Metastatic Prostate Cancer. Psycho-Oncology 2008, 18(3):237-247. 21. Shelton AL, Gabrieli JD: Neural correlates of encoding space from route and survey perspectives. J Neurosci 2002, 22(7):2711-2717. 22. Shelton AL, McNamara TP: Spatial memory and perspective taking. Memory & cognition 2004, 32(3):416-426. 23. Cohen JD, MacWhinney B, Flatt M, Provost J: Psyscope: A new graphic interface environment for designing psychological experiments. Behavioral Research Methods, Instruments and Computers 1993, 25. 24. Shepard RN, Metzler J: Mental rotation of three-dimensional objects. Science 1971, 171(972):701-703. 25. Shepard S, Metzler D: Mental rotation: effects of dimensionality of objects and type of task. J Exp Psychol Hum Percept Perform 1988, 14(1): 3-11. 26. Jenkinson M, Bannister P, Brady M, Smith S: Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage 2002, 17(2):825-841. 27. Beckmann CF, Smith SM: Probabilistic Independent Component Analysis for Functional Magnetic Resonance Imaging. IEEE Trans Med Imaging 2004, 23(2):137-152. 28. Jenkinson M, Smith S: A global optimisation method for robust affine registration of brain images. Medical image analysis 2001, 5(2):143-156. 29. Woolrich MW, Behrens TE, Beckmann CF, Jenkinson M, Smith SM: Multilevel linear modelling for FMRI group analysis using Bayesian inference. Neuroimage 2004, 21(4):1732-1747. 30. Woolrich MW, Jenkinson M, Brady JM, Smith SM: Fully Bayesian spatio- temporal modeling of FMRI data. IEEE transactions on medical imaging 2004, 23(2):213-231. 31. Jenkins VA, Bloomfield DJ, Shilling VM, Edginton TL: Does neoadjuvant hormone therapy for early prostate cancer affect cognition? Results from a pilot study. BJU Int 2005, 96(1):48-53. 32. Almeida OP, Waterreus A, Spry N, Flicker L, Martins RN: One year follow-up study of the association between chemical castration, sex hormones, beta-amyloid, memory and depression in men. Psychoneuroendocrinology 2004, 29(8):1071-1081. 33. Aso T, Hanakawa T, Matsuo K, Toma K, Shibasaki H, Fukuyama H, Nakai T: Subregions of human parietal cortex selectively encoding object orientation. Neurosci Lett 2007, 415(3):225-230. 34. Shelton AL, Pippitt HA: Motion in the mind’s eye: comparing mental and visual rotation. Cogn Affect Behav Neurosci 2006, 6(4):323-332. 35. Gizewski ER, Krause E, Wanke I, Forsting M, Senf W: Gender-specific cerebral activation during cognitive tasks using functional MRI: Page 8 of 8 comparison of women in mid-luteal phase and men. Neuroradiology 2006, 48(1):14-20. 36. Jordan K, Wustenberg T, Heinze HJ, Peters M, Jancke L: Women and men exhibit different cortical activation patterns during mental rotation tasks. Neuropsychologia 2002, 40(13):2397-2408. 37. Kimura D: Sex and Cognition. Cambridge, MA: The MIT Press 1999. 38. Driscoll I, Hamilton DA, Yeo RA, Brooks WM, Sutherland RJ: Virtual navigation in humans: the impact of age, sex, and hormones on place learning. Horm Behav 2005, 47(3):326-335. 39. Hooven CK, Chabris CF, Ellison PT, Kosslyn SM: The relationship of male testosterone to components of mental rotation. Neuropsychologia 2004, 42(6):782-790. 40. Shelton AL, Pippitt HA: Fixed versus dynamic orientations in environmental learning from ground-level and aerial perspectives. Psychological research 2007, 71(3):333-346. 41. Zitzmann M, Weckesser M, Schober O, Nieschlag E: Changes in cerebral glucose metabolism and visuospatial capability in hypogonadal males under testosterone substitution therapy. Exp Clin Endocrinol Diabetes 2001, 109(5):302-304. 42. Moffat SD, Resnick SM: Long-term measures of free testosterone predict regional cerebral blood flow patterns in elderly men. Neurobiol Aging 2007, 28:914-920. 43. Maki PM, Ernst M, London ED, Mordecai KL, Perschler P, Durso SC, Brandt J, Dobs A, Resnick SM: Intramuscular Testosterone Treatment in Elderly Men: Evidence of Memory Decline and Altered Brain Function. J Clin Endocrinol Metab 2007. 44. Hinkin CH, van Gorp WG, Satz P, Marcotte T, Durvasula RS, Wood S, Campbell L, Baluda MR: Actual versus self-reported cognitive dysfunction in HIV-1 infection: memory-metamemory dissociations. J Clin Exp Neuropsychol 1996, 18(3):431-443. 45. Snitz BE, Morrow LA, Rodriguez EG, Huber KA, Saxton JA: Subjective memory complaints and concurrent memory performance in older patients of primary care providers. J Int Neuropsychol Soc 2008, 14(6):1004-1013. 46. Mitchell AJ: The clinical significance of subjective memory complaints in the diagnosis of mild cognitive impairment and dementia: a meta- analysis. Int J Geriatr Psychiatry 2008, 23(11):1191-1202. 47. Jacobs SR, Jacobsen PB, Booth-Jones M, Wagner LI, Anasetti C: Evaluation of the functional assessment of cancer therapy cognitive scale with hematopoietic stem cell transplant patients. J Pain Symptom Manage 2007, 33(1):13-23. 48. McDonald BC, Saykin AJ, Ahles TA: Brain Imaging Investigation of Chemotherapy-Induced Neurocognitive Changes. Cancer and Cognition New York: CambridgeMeyers CA, Perry JR 2008, 19-32. Pre-publication history The pre-publication history for this paper can be accessed here:http://www. biomedcentral.com/1471-2407/10/1/prepub doi:10.1186/1471-2407-10-1 Cite this article as: Cherrier et al.: Changes in neuronal activation patterns in response to androgen deprivation therapy: a pilot study. BMC Cancer 2010 10:1. Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color ﬁgure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit