D’Auria et al. BMC Genomics 2010, 11:181 http://www.biomedcentral.com/1471-2164/11/181 Table 2 Accessory genes islands Island Genome Details type Resistance related islands (R) Alcoy Contains several multi-drug related protein Corby Philadelphia R1 Paris Antibiotic persistance related system HipB/HipA; Phage related proteins Xre, and multi-drug efflux pump Lens Methylase, prophage integrase, TraK homologous R2 Lens Stability system StbDE Transport/secretion systems(TS) Alcoy Cobalt/zinc/cadmium efflux transporter helABC; ArsR regulatory TS1 proteins Corby Cobalt/zinc/cadmium efflux transporter helABC DNA transfer (DT) Alcoy tra and trb conjugal transfer proteins, Rac integrase roteins, htpX protease prophage regulatory protein alpA DT1 DT2 Corby Alcoy Corby Paris DT3 Philadelphia Lens CRISPR systems (C) C1 Lens Alcoy Putative RNA helicase, two putative restrictases, tra and trb conjugal transfer proteins. Plasmid-like elements containing lvh, lvr Really similar CRISPR system C2 Paris *Part of above P2 island Integrated phage related (PR) Alcoy MviN virulence factor PR1 Corby Philadelphia PR2 Philadelphia Mainly transposases PR3 Corby Alcoy Ankyrine containing domain PR4 Lens Plasmid maintenance killer/antidote system PR5 Alcoy Bacilysin system PR6 Philadelphia Type IV secretion system PR7 Paris Probable phage integration Not well defined (ND) ND1 Paris Cytochrome o ND2 Paris Carbon storage regulator ND3 Paris Nickel/Cobalt type II transport systems ND4 Philadelphia No clear role ND5 Philadelphia Mainly transposases and phages integrases ND6 Corby No clear role ND7 Lens Incomplete HipA/HipB system ND8 Paris No clear role ND9 Paris No clear role GC % 3534 35.30 33.96 38.05 36.77 40.83 40.75 39.40 38.56 39.11 39.52 39.25 39.90 37.47 39.13 40.75 38.49 .... 36.14 36.23 37.33 35.14 38.11 37.00 34.79 36.78 38.04 36.62 38.77 36.76 39.63 35.17 34.97 36.78 34.77 38.09 37.57 Page 6 of 13 # of Length Transposase CDSs 19632 19184 9303 18359 14310 11962 16382 50500 49259 59850 39082 43398 50213 47184 66581 21475 10167 .... 37021 46673 17305 10404 38520 23739 29080 27433 69547 11256 9093 6385 2955 10889 12455 7074 11870 12934 7341 + + + + + + + + - - - - - + - - - .... + + + + + + + + + - - - - + + - - + + Position 68252 - 87883 69153 - 88336 68096 - 77398 66766 - 85124 68898 - 83207 1755441 - 1767402 1251900 - 1268281 2781725 - 2832225 181578 - 230836 181312 - 241161 609680 - 648761 613277 - 656674 183831 - 234043 1353613 - 1400796 172914 - 239494 3226572 - 3248046 1169086 - 1179252 1292822 - 1329842 1278158 - 1324830 1167775 - 1185079 173401 - 183804 2493848 - 2532367 2486005 - 2509743 1190582 - 1219661 2756698 - 2784130 2296937 - 2366483 2408503 - 2419758 325750 - 334842 1192799 - 1199183 1353408 - 1356362 1439890 - 1450778 2892417 - 2904871 1182245 - 1189318 2605322 - 2617191 1733202 - 1746135 2654264 - 2661604 22 22 9 21 10 10 16 56 61 63 40 42 45 45 64 16 6 30 49 15 10 11 6 30 33 64 16 10 10 6 10 16 9 12 7 9 .. *45