Hu and Gallo BMC Genomics 2010, 11:49 http://www.biomedcentral.com/1471-2164/11/49 Page 5 of 15 Table 1: Summary of the identified tissue and tissue-unique TF pairs as well as top 5 tissue TF pairs in the 79 human tissues. (Continued) BM CD71+ 145 earlyerythroid BM_CD33+ myeloid 164 Bone marrow 154 Lymph node 157 PB BDCA4+ dentritic 159 cells PB CD14+ monocytes 146 PB CD19+ Bcells 143 PB CD4+ Tcells 161 PB CD56+ NKCells PB CD8+ Tcells Thymus Tonsil Whole blood Ovary Testis Testis germ cell Testis interstitial Testis leydig cell Testis seminiferous tubule Adrenal cortex Adrenal gland Fetal thyroid Pituitary gland Prostate Salivary gland Thyroid 125 155 164 158 132 127 149 136 115 135 157 147 157 127 133 176 132 122 721 B lymphoblasts 168 Colorectal 143 adenocarcinoma Leukemia chronic 151 myelegenous Leukemia 156 lymphoblastic Leukemia 154 promyelocytic Lymphoma burkitts 147 daudi Lymphoma burkitts 131 Raji Adipocyte 142 Appendix 136 Atrioventricular node 140 Bronchial epithelial 152 cells Placenta 132 8 16 16 7 9 9 5 10 10 8 11 10 8 9 9 8 5 6 9 17 8 9 19 12 11 11 11 11 9 17 6 5 12 14 8 13 14 5 PAX4:YY1*, GEN_INI3_B:GEN_INI3_B, KROX:NF1*, NF1:SP1*, CP2:CP2 CEBP:CEBPA**, ETS:VDR**, AP2ALPHA:EGR1* P300:SREBP1, CETS1P54:VDR* CEBP:CEBPA**, DR4:SPZ1*, AP2:OCT4, VDR:SREBP*, DR3:WT1* MINI19_B:LRF, OCT4:PAX4, CP2:ZIC3, AP2ALPHA:TTF1, TAL1BETAE47:PPARA* CEBPA:CEBPGAMMA**, KROX:PPARA*, CEBP:TST1*, TST1:PAX2*, DR3:P300* [41,49] [41] [41] CEBP:CEBPA**, TFE:TST1*, NF1:PAX8, NF1:ZIC3, MYOGNF1:SP1* [41] HMGIY:OCT**, DBP:TBP*, ETS:HOXA4*, CP2:CP2, RUSH1A:RUSH1A [46] ETS:SP1**, CEBPGAMMA:CEBPGAMMA**, CP2:SZF11, FAC1:VMYB, AREB6: [41,55] GATA4 ETS:GRE_C, CEBPA:CEBPGAMMA**, OCT1:SPZ1* CEBP:TST1*, AP2:GRE_C [41] ETS:SP1**, AREB6:GATA4, AP2ALPHA:MAZ, TTF1:OCT1_07*, KROX:XVENT1* [55] EBOX:HNF4ALPHA**, CEBPA:CEBPGAMMA**, AP1:STAT**, ETS:RUSH1A*, TBP: [41,42] YY1* CEBP:CEBPGAMMA**, NF1:P300, CACD:TAL1BETAE47*, PPARA:SP1*, OSF2: [41] CDXA CEBPGAMMA:CEBPGAMMA**, PPARA:SP3*, ETS:VMYB*, SP3:YY1*, NFAT:PLZF* [41] CEBPA:SREBP1, GATA_C:MAF, LRF:NKX25, NF1:ZIC3, CHOP:PAX4 CEBPGAMMA:CEBPGAMMA**, DR4:SPZ1*, POU3F2:PAX4, MYOGNF1:ZIC3, [41] MYOGNF1:SP1 HAND1E47:SPZ1*, SP3:WT1, DBP:TBP, TEL2:LRF, POU3F2:COUP_DR1 CEBP:CEBPGAMMA**, MYOGNF1:SPZ1*, DR4:SPZ1*, CEBPGAMMA:HMGIY, [41] EBOX:SREBP1 MYOGNF1:SPZ1*, FAC1:FOXJ2, TTF1:PPARA, GATA4:RUSH1A, HOXA4:OCT STAT:STAT**, DR4:SPZ1*, FAC1:FOXJ2, AHRHIF:AP2ALPHA, CMAF:PPARA [56] CEBP:NFAT**, PPARA:SP1, HMGIY:ZF5_B, AP2:TST1, AP2ALPHA:TST1 [57] PAX3:WT1, PPARA:SP3, TAL1BETAE47:CRX, DR3:SP3, CETS1P54:OCT CEBPA:CEBPGAMMA**, TST1:PAX2, CART1:PPARA, DR3:SP3, AP2:PPARA [41] EBOX:P300, OSF2:YY1, AP2:PPARA, SP3:WT1, EGR1:ZF5_B* CEBPA:ETS**, EBOX:ETS**, ETS:VDR**, AP1:DR3, KROX:NF1 [43,58] CEBPGAMMA:CEBPGAMMA**, AP2:POU3F2, TTF1:TTF1, CEBPA:CEBPGAMMA, [41] EGR1:P300 CEBPA:CEBPGAMMA**, PPARA:SREBP1, GRE_C:SREBP1, MINI19_B:DR3, CMAF: [41] YY1 CART1:YY1, CP2:ZIC3, HMGIY:PAX4, DBP:TTF1, TEL2:P300 FOXJ2:EFC, CART1:HOXA4, MINI19_B:DR4, SP3:WT1, OCT4:PAX2 TCF11:NFAT, NCX:PAX2, ETF:SRY, NF1:ZIC3, AP2ALPHA:AREB6 AP2ALPHA:PAX4, CEBPA:PLZF, AP2ALPHA:TST1, AP2:PPARA, HMGIY:ZF5_B CEBPGAMMA:CEBPGAMMA**, DR4:SPZ1, CEBPA:FAC1, P300:ZIC3, CP2:ZIC3 ETS:MYB**, CETS1P54:WT1, CP2:P300, CP2:EBOX, MINI19_B:WT1 NFAT:OCT1**, PPARA:SP3, E2A:MYOGNF1, CETS1P54:MYB, AREB6:CDPCR3 [60,61] PPARA:SP1, EGR1:ZF5_B, SP3:SP3, AP2:SRY, PPARA:WT1 CEBP:NFAT**, ETS:VDR**, TAL1BETAE47:TEL2, SP3:WT1, DR4:SP3 ETS:GRE_C, AREB6:PPARA, ETF:HOXA4, GEN_INI3_B:GEN_INI3_B, AP2:OCT4 TTF1:SP1, POU3F2:GATA4, AP2ALPHA:TTF1, CACD:MAZ, CEBPA:GATA4 CEBPA:CEBPGAMMA**, SP3:WT1*, DEC:PAX5, NKX25:STAT1, PPARA:SP1 [41] [59] [57] [41]