BMC Cancer Research article BioMed Central Open Access Nuclear receptor coregulator SNP discovery and impact on breast cancer risk Ryan J Hartmaier†1,2, Sandrine Tchatchou†3,4, Alexandra S Richter2,5, Jay Wang2, Sean E McGuire20, Todd C Skaar6, Jimmy M Rae7, Kari Hemminki8,9, Christian Sutter10, Nina Ditsch11, Peter Bugert12, Bernhard HF Weber13, Dieter Niederacher14, Norbert Arnold15, Raymonda Varon-Mateeva16, Barbara Wappenschmidt17, Rita K Schmutzler17, Alfons Meindl18, Claus R Bartram10, Barbara Burwinkel3,4 and Steffi Oesterreich*1,2,19,20 Address: 1Program in Translational Biology & Molecular Medicine, Baylor College of Medicine, 1 Baylor Plaza, Houston TX, 77030, USA, 2Lester & Sue Smith Breast Center, Baylor College of Medicine, 1 Baylor Plaza, Houston TX, 77030, USA, 3Division Molecular Biology of Breast Cancer, Department of Gynecology and Obstetrics, University of Heidelberg, Voßstrasse9, 69115 Heidelberg, Germany, 4Helmholtz-University Group Molecular Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany, 5Martin-Luther- Universitaet Halle-Wittenberg, Universitätsplatz 10, 06108 Halle, Germany, 6Division of Clinical Pharmacology, Indiana University School of Medicine, 1120 South Drive, Indianapolis, IN, 46202, USA, 7University of Michigan, 1150 W Medical Center Drive, Ann Arbor, MI, 48109, USA, 8Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, Germany, 69120 Heidelberg, Germany, 9Department of Biosciences at Novum, Karolinska Institute, 14157 Huddinge, Sweden, 10Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany, 11Department for Obstetrics and Gynaecology, Ludwig Maximilians Universität, Marchioninistr 15, 81377 Munich, Germany, 12Institute of Transfusion Medicine and Immunology, Red Cross Blood Service of Baden- Württemberg-Hessen, University of Heidelberg, Medical Faculty of Mannheim, Friedrich-Ebert-Str 107, 68167 Mannheim, Germany, 13Institute of Human Genetics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany, 14Division of Molecular Genetics, Department of Gynaecology and Obstetrics, Clinical Center University of Düsseldorf, 40225 Düsseldorf, Germany, 15Division of Oncology, Department of Gynaecology and Obstetrics, University Hospital Schleswig-Holstein, Arnold-Heller-Str 3, 24105 Kiel, Germany, 16Institut für Humangenetik, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany, 17Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, Center of Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Kerpener Straße 34, 50931 Cologne, Germany, 18Division of Gynecology and Obstetrics, Klinikum rechts der Isar at the Technical University Munich, 80336 Munich, Germany, 19Departments of Medicine, Baylor College of Medicine, 1 Baylor Plaza, Houston TX, 77030, USA and 20Molecular & Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston TX, 77030, USA Email: Ryan J Hartmaier - hartmaie@bcm.edu; Sandrine Tchatchou - s.tchatchou@dkfz-heidelberg.de; Alexandra S Richter - asrichte@bcm.edu; Jay Wang - jayw@bcm.edu; Sean E McGuire - semcguir@bcm.edu; Todd C Skaar - tskaar@iupui.edu; Jimmy M Rae - jimmyrae@med.umich.edu; Kari Hemminki - k.heminki@dkfz-heidelberg.de; Christian Sutter - c.sutter@med.uni-heidelberg.de; Nina Ditsch - nina.ditsch@med.uni-muenchen.de; Peter Bugert - p.bugert@blutspende.de; Bernhard HF Weber - bweb@klinik.uni- regensburg.de; Dieter Niederacher - niederac@uni-duesseldorf.de; Norbert Arnold - nkarnold@email.uni-kiel.de; Raymonda Varon- Mateeva - raymonda.varon-mateeva@charite.de; Barbara Wappenschmidt - barbara.wappenschmidt@uk-koeln.de; Rita K Schmutzler - rita.schmutzler@uk-koeln.de; Alfons Meindl - alfons.meindl@lrz.tum.de; Claus R Bartram - cr_bartram@med.uni- heidelberg.de; Barbara Burwinkel - B.Burwinkel@dkfz-heidelberg.de; Steffi Oesterreich* - steffio@bcm.edu * Corresponding author †Equal contributors Published: 14 December 2009 BMC Cancer 2009, 9:438 doi:10.1186/1471-2407-9-438 This article is available from: http://www.biomedcentral.com/1471-2407/9/438 Received: 30 July 2009 Accepted: 14 December 2009 © 2009 Hartmaier et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Page 1 of 9 (page number not for citation purposes)