Bao and Xu BMC Genomics 2011, 12:224 http://www.biomedcentral.com/1471-2164/12/224 Page 10 of 14 Figure 5 Schematic representation of gene functions at diapause initiation. Red represents up-regulated gene and blue represents down- regulated gene in diapause- destined individuals. (A) Changes in metabolism and energy at diapause initiation. (B) Gene expression changes in response to environmental stress. (C) Changes in signaling pathways at diapause initiation.