BMC Genomics 2007, 8:139 http://www.biomedcentral.com/1471-2164/8/139 9. Clarke AR, Gledhill S, Hooper ML, Bird CC, Wyllie AH: p53 depend- ence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation. Oncogene 1994, 9(6):1767-1773. 10. Armstrong JF, Kaufman MH, Harrison DJ, Clarke AR: High-fre- quency developmental abnormalities in p53-deficient mice. Curr Biol 1995, 5(8):931-936. 11. Sah VP, Attardi LD, Mulligan GJ, Williams BO, Bronson RT, Jacks T: A subset of p53-deficient embryos exhibit exencephaly. Nat Genet 1995, 10(2):175-180. 12. Komarova EA, Chernov MV, Franks R, Wang K, Armin G, Zelnick CR, Chin DM, Bacus SS, Stark GR, Gudkov AV: Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sen- sitivity in vivo. Embo J 1997, 16(6):1391-1400. 13. Schmid P, Lorenz A, Hameister H, Montenarh M: Expression of p53 during mouse embryogenesis. Development 1991, 113(3):857-865. 14. Wallingford JB, Seufert DW, Virta VC, Vize PD: p53 activity is essential for normal development in Xenopus. Curr Biol 1997, 7(10):747-757. 15. Louis JM, McFarland VW, May P, Mora PT: The phosphoprotein p53 is down-regulated post-transcriptionally during embryo- genesis in vertebrates. Biochim Biophys Acta 1988, 950(3):395-402. 16. Krinka D, Raid R, Pata I, Karner J, Maimets T: In situ hybridisation of chick embryos with p53-specific probe and their immunos- taining with anti-p53 antibodies. Anat Embryol (Berl) 2001, 204(3):207-215. 17. Poulaki V, Benekou A, Bozas E, Bolaris S, Stylianopoulou F: p53 expression and regulation by NMDA receptors in the devel- oping rat brain. J Neurosci Res 1999, 56(4):427-440. 18. Eizenberg O, Faber-Elman A, Gottlieb E, Oren M, Rotter V, Schwartz M: p53 plays a regulatory role in differentiation and apoptosis of central nervous system-associated cells. Mol Cell Biol 1996, 16(9):5178-5185. 19. Sadoul R, Quiquerez AL, Martinou I, Fernandez PA, Martinou JC: p53 protein in sympathetic neurons: cytoplasmic localization and no apparent function in apoptosis. J Neurosci Res 1996, 43(5):594-601. 20. Lin T, Chao C, Saito S, Mazur SJ, Murphy ME, Appella E, Xu Y: p53 induces differentiation of mouse embryonic stem cells by sup- pressing Nanog expression. Nat Cell Biol 2005, 7(2):165-171. 21. Takebayashi-Suzuki K, Funami J, Tokumori D, Saito A, Watabe T, Miya- zono K, Kanda A, Suzuki A: Interplay between the tumor sup- pressor p53 and TGF beta signaling shapes embryonic body axes in Xenopus. Development 2003, 130(17):3929-3939. 22. Rotter V, Schwartz D, Almon E, Goldfinger N, Kapon A, Meshorer A, Donehower LA, Levine AJ: Mice with reduced levels of p53 pro- tein exhibit the testicular giant-cell degenerative syndrome. Proc Natl Acad Sci U S A 1993, 90(19):9075-9079. 23. Reichel MB, Ali RR, D'Esposito F, Clarke AR, Luthert PJ, Bhattacharya SS, Hunt DM: High frequency of persistent hyperplastic pri- mary vitreous and cataracts in p53-deficient mice. Cell Death Differ 1998, 5(2):156-162. 24. Saifudeen Z, Dipp S, El-Dahr SS: A role for p53 in terminal epithe- lial cell differentiation. J Clin Invest 2002, 109(8):1021-1030. 25. Lengner CJ, Steinman HA, Gagnon J, Smith TW, Henderson JE, Kream BE, Stein GS, Lian JB, Jones SN: Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling. J Cell Biol 2006, 172(6):909-921. 26. Matas D, Milyavsky M, Shats I, Nissim L, Goldfinger N, Rotter V: p53 is a regulator of macrophage differentiation. Cell Death Differ 2004, 11(4):458-467. 27. Tebar M, Boex JJ, Ten Have-Opbroek AA: Functional overexpres- sion of wild-type p53 correlates with alveolar cell differentia- tion in the developing human lung. Anat Rec 2001, 263(1):25-34. 28. Porrello A, Cerone MA, Coen S, Gurtner A, Fontemaggi G, Cimino L, Piaggio G, Sacchi A, Soddu S: p53 regulates myogenesis by trig- gering the differentiation activity of pRb. J Cell Biol 2000, 151(6):1295-1304. 29. Facchetti M, Uberti D, Memo M, Missale C: Nerve growth factor restores p53 function in pituitary tumor cell lines via trkA- mediated activation of phosphatidylinositol 3-kinase. Mol Endocrinol 2004, 18(1):162-172. 30. Stuhmer T, Bargou RC: Selective pharmacologic activation of the p53-dependent pathway as a therapeutic strategy for hematologic malignancies. Cell Cycle 2006, 5(1):39-42. 31. Stuhmer T, Chatterjee M, Hildebrandt M, Herrmann P, Gollasch H, Gerecke C, Theurich S, Cigliano L, Manz RA, Daniel PT, Bommert K, Vassilev LT, Bargou RC: Nongenotoxic activation of the p53 pathway as a therapeutic strategy for multiple myeloma. Blood 2005, 106(10):3609-3617. 32. Secchiero P, Barbarotto E, Tiribelli M, Zerbinati C, di Iasio MG, Gonelli A, Cavazzini F, Campioni D, Fanin R, Cuneo A, Zauli G: Functional integrity of the p53-mediated apoptotic pathway induced by the nongenotoxic agent nutlin-3 in B-cell chronic lymphocytic leukemia (B-CLL). Blood 2006, 107(10):4122-4129. 33. Foster BA, Coffey HA, Morin MJ, Rastinejad F: Pharmacological rescue of mutant p53 conformation and function. Science 1999, 286(5449):2507-2510. 34. Krieg AJ, Hammond EM, Giaccia AJ: Functional analysis of p53 binding under differential stresses. Mol Cell Biol 2006, 26(19):7030-7045. 35. Greene LA, Tischler AS: Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci U S A 1976, 73(7):2424-2428. 36. Angelastro JM, Klimaschewski L, Tang S, Vitolo OV, Weissman TA, Donlin LT, Shelanski ML, Greene LA: Identification of diverse nerve growth factor-regulated genes by serial analysis of gene expression (SAGE) profiling. Proc Natl Acad Sci U S A 2000, 97(19):10424-10429. 37. Vaudry D, Stork PJ, Lazarovici P, Eiden LE: Signaling pathways for PC12 cell differentiation: making the right connections. Sci- ence 2002, 296(5573):1648-1649. 38. Vaghefi H, Neet KE: Deacetylation of p53 after nerve growth factor treatment in PC12 cells as a post-translational modifi- cation mechanism of neurotrophin-induced tumor suppres- sor activation. Oncogene 2004, 23(49):8078-8087. 39. Zhang J, Yan W, Chen X: p53 is required for nerve growth factor- mediated differentiation of PC12 cells via regulation of TrkA levels. Cell Death Differ 2006, 13:2118-2128. 40. Fabian Z, Vecsernyes M, Pap M, Szeberenyi J: The effects of a mutant p53 protein on the proliferation and differentiation of PC12 rat phaeochromocytoma cells. J Cell Biochem 2006, 99:1431-1441. 41. Di Giovanni S, Knights CD, Rao M, Yakovlev A, Beers J, Catania J, Avantaggiati ML, Faden AI: The tumor suppressor protein p53 is required for neurite outgrowth and axon regeneration. Embo J 2006, 25(17):4084-4096. 42. Suzuki T, Kurahashi H, Ichinose H: Ras/MEK pathway is required for NGF-induced expression of tyrosine hydroxylase gene. Biochem Biophys Res Commun 2004, 315(2):389-396. 43. Dahlstrand J, Lardelli M, Lendahl U: Nestin mRNA expression cor- relates with the central nervous system progenitor cell state in many, but not all, regions of developing central nervous system. Brain Res Dev Brain Res 1995, 84(1):109-129. 44. Hughes AL, Gollapudi L, Sladek TL, Neet KE: Mediation of nerve growth factor-driven cell cycle arrest in PC12 cells by p53. Simultaneous differentiation and proliferation subsequent to p53 functional inactivation. J Biol Chem 2000, 275(48):37829-37837. 45. Gollapudi L, Neet KE: Different mechanisms for inhibition of cell proliferation via cell cycle proteins in PC12 cells by nerve growth factor and staurosporine. J Neurosci Res 1997, 49(4):461-474. 46. Sun CN, Cheng HC, Chou JL, Lee SY, Lin YW, Lai HL, Chen HM, Chern Y: Rescue of p53 blockage by the A(2A) adenosine receptor via a novel interacting protein, translin-associated protein X. Mol Pharmacol 2006, 70(2):454-466. 47. Hoh J, Jin S, Parrado T, Edington J, Levine AJ, Ott J: The p53MH algo- rithm and its application in detecting p53-responsive genes. Proc Natl Acad Sci U S A 2002, 99(13):8467-8472. 48. Li J, Tan M, Li L, Pamarthy D, Lawrence TS, Sun Y: SAK, a new polo- like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing. Neoplasia 2005, 7(4):312-323. 49. Zhang L, Yu D, Hu M, Xiong S, Lang A, Ellis LM, Pollock RE: Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial sarcoma by transcriptional suppression of vascular endothelial growth factor expression. Cancer Res 2000, 60(13):3655-3661. 50. Hoffman WH, Biade S, Zilfou JT, Chen J, Murphy M: Transcriptional repression of the anti-apoptotic survivin gene by wild type p53. J Biol Chem 2002, 277(5):3247-3257. 51. Budanov AV, Shoshani T, Faerman A, Zelin E, Kamer I, Kalinski H, Gorodin S, Fishman A, Chajut A, Einat P, Skaliter R, Gudkov AV, Chu- makov PM, Feinstein E: Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability. Oncogene 2002, 21(39):6017-6031. 52. Chen SL, Wu YS, Shieh HY, Yen CC, Shen JJ, Lin KH: P53 is a regu- lator of the metastasis suppressor gene Nm23-H1. Mol Car- cinog 2003, 36(4):204-214. Page 16 of 17 (page number not for citation purposes)