Zhou et al. BMC Genomics 2011, 12:124 http://www.biomedcentral.com/1471-2164/12/124 Table 2 Genes with changed expression† (Continued) A630082K20Rik Mm.293175 1427359_at Acsl6 Mm.267478 1451257_at Atp1a1 Mm.280103 1451071_a_at AW547365 Mm.270088 1433645_at C78212 Cad Cdv3 Clstn1 Cpd E130306I01Rik Emb Exosc2 Hmga2 Hsd11b2 Ide Ifrg15 Ipo11 Itga6 Klf16 Ndufs1 Phf13 Podxl Psmd3 Ptcd1 Rhou Rpo1-4 Saa2 Slc27a4 Mm.27090 1435369_at Mm.305535 1452830_s_at Mm.261025 1415704_a_at Mm.38993 1421861_at Mm.276736 1434547_at Mm.277582 1424419_at Mm.274926 1415856_at Mm.150972 1426630_at Mm.157190 1450780_s_at Mm.5079 1416761_at Mm.28366 1423120_at Mm.253335 1418116_at Mm.132208 1428096_at Mm.225096 1422445_at Mm.41513 1416350_at Mm.290791 1425143_a_at Mm.25582 1455175_at Mm.89918 1448688_at Mm.12194 1448479_at Mm.332840 1454970_at Mm.168257 1449027_at Mm.135581 1417775_at Mm.200941 1419075_s_at Mm.330113 1424441_at Trp53bp1 Mm.215389 1433659_at Ttr Mm.2108 1454608_x_at Ube2j1 Mm.259095 1417723_at 0610007A15Rik Mm.28122 1452132_at 1110060D06Rik Mm.319964 1430291_at 1300001I01Rik Mm.214574 1428106_at 1700017B05Rik Mm.22712 1429758_at 1700054N08Rik Mm.157746 1451483_s_at 4632417K18Rik Mm.1643 1422628_at 4930485D02Rik Mm.293449 1424810_at 5930416I19Rik Mm.143908 1452313_at †P < 0.05. -1.7 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.1 1.3 1.1 1.2 1.4 1.2 1.1 1.2 1.1 1.3 1.1 1.2 1.3 1.1 1.4 1.2 1.2 1.7 1.2 1.1 2 1.2 1.8 1.3 1.2 1.3 1.4 1.2 1.3 1.2 did not reach the criteria for significance. The additional growth genes in Epidermal growth factor receptor (EGFR) signaling pathway GO group appear to be reduced to a greater extent in ALC-NTO than in ALC- NTC (Table 4). b. Stem Cell Related Gene Sets Three gene sets were enriched in the control embryos compared to the combined alcohol-treated embryos (i.e., down-regulated in the alcohol-treated group): TGF-Beta activin-responsive genes (important for maintenance of -1.3 1.4 1.2 1.2 1.3 1.3 1.2 1.2 1.2 1.3 1.2 1.2 1.1 1.4 1.2 1.1 1.2 1.2 1.3 1.1 1.1 1.3 1.2 1.3 1.2 1.1 1.7 1.3 1.2 1.6 1.3 1.5 1.3 1.2 1.3 1.2 1.1 1.3 1.1 Page 7 of 17 Lipid metabolism Energy Membrane Transport RIKEN cDNA A630082K20 gene acyl-CoA synthetase long-chain family member 6 ATPase, Na+/K+ transporting, alpha 1 polypeptide expressed sequence AW547365 Expressed sequence C78212 Amino acid carbamoyl-phosphate synthetase 2, aspartate metabolism transcarbamylase, and dihydroorotase Lipid metabolism carnitine deficiency-associated gene expressed in ventricle 3 Cell adhesion Calsyntenin 1 Protease activity carboxypeptidase D RIKEN cDNA E130306I01 gene Cell adhesion embigin RNA degradation exosome component 2 high mobility group AT-hook 2 Steroid Metabolism Hydroxysteroid 11-beta dehydrogenase 2 Protease activity Insulin degrading enzyme interferon alpha responsive gene Nuclear Protein importin 11 Transport Cell adhesion integrin alpha 6 Alcohol metabolism Kruppel-like factor 16 Energy NADH dehydrogenase (ubiquinone) Fe-S protein 1 Alcohol metabolism PHD finger protein 13 hematopoiesis, Podocalyxin-like kinase Proteasome Proteasome (prosome, macropain) 26 S subunit, non- ATPase, 3 pentatricopeptide repeat domain 1 Signal transduction ras homolog gene family, member U Synthesis RNA polymerase 1-4 Lipid metabolism serum amyloid A 2 Lipid metabolism solute carrier family 27 (fatty acid transporter), member 4 Cell cycle transformation related protein 53 binding protein 1 Retinol Transthyretin Epigenetic ubiquitin-conjugating enzyme E2, J1 RIKEN cDNA 0610007A15 gene Adult male corpora quadrigemina cDNA, RIKEN full- length enriched library, clone:B230210C03 product:u RIKEN cDNA 1300001I01 gene RIKEN cDNA 1700017B05 gene RIKEN cDNA 1700054N08 gene RIKEN cDNA 4632417K18 gene RIKEN cDNA 4930485D02 gene RIKEN cDNA 5930416I19 gene