Zhou et al. BMC Genomics 2011, 12:124 http://www.biomedcentral.com/1471-2164/12/124 6. Burd L, Deal E, Rios R, Adickes E, Wynne J, Klug MG: Congenital heart defects and fetal alcohol spectrum disorders. Congenit Heart Dis 2007, 2(4):250-255. 7. Climent E, Pascual M, Renau-Piqueras J, Guerri C: Ethanol exposure enhances cell death in the developing cerebral cortex: role of brain- derived neurotrophic factor and its signaling pathways. J Neurosci Res 2002, 68(2):213-225. 8. Miller MW, Kuhn PE: Cell cycle kinetics in fetal rat cerebral cortex: effects of prenatal treatment with ethanol assessed by a cumulative labeling technique with flow cytometry. Alcohol Clin Exp Res 1995, 19(1):233-237. 9. Ikonomidou C, Bittigau P, Ishimaru MJ, Wozniak DF, Koch C, Genz K, Price MT, Stefovska V, Horster F, Tenkova T, et al: Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome. Science 2000, 287(5455):1056-1060. 10. Light KE, Belcher SM, Pierce DR: Time course and manner of Purkinje neuron death following a single ethanol exposure on postnatal day 4 in the developing rat. Neuroscience 2002, 114(2):327-337. 11. Holownia A, Ledig M, Menez JF: Ethanol-induced cell death in cultured rat astroglia. Neurotoxicol Teratol 1997, 19(2):141-146. 12. Kotch LE, Sulik KK: Patterns of ethanol-induced cell death in the developing nervous system of mice; neural fold states through the time of anterior neural tube closure. Int J Dev Neurosci 1992, 10(4):273-279. 13. Ewald SJ, Shao H: Ethanol increases apoptotic cell death of thymocytes in vitro. Alcohol Clin Exp Res 1993, 17(2):359-365. 14. Sulik KK: Genesis of alcohol-induced craniofacial dysmorphism. Exp Biol Med (Maywood) 2005, 230(6):366-375. 15. Kilburn BA, Chiang PJ, Wang J, Flentke GR, Smith SM, Armant DR: Rapid induction of apoptosis in gastrulating mouse embryos by ethanol and its prevention by HB-EGF. Alcohol Clin Exp Res 2006, 30(1):127-134. 16. Smith SM: Alcohol-induced cell death in the embryo. Alcohol Health Res World 1997, 21(4):287-297. 17. Goodlett CR, Horn KH, Zhou FC: Alcohol teratogenesis: mechanisms of damage and strategies for intervention. Exp Biol Med (Maywood) 2005, 230(6):394-406. 18. Rifas L, Towler DA, Avioli LV: Gestational exposure to ethanol suppresses msx2 expression in developing mouse embryos. Proc Natl Acad Sci USA 1997, 94(14):7549-7554. 19. Ahlgren SC, Thakur V, Bronner-Fraser M: Sonic hedgehog rescues cranial neural crest from cell death induced by ethanol exposure. Proc Natl Acad Sci USA 2002, 99(16):10476-10481. 20. Yamada Y, Nagase T, Nagase M, Koshima I: Gene expression changes of sonic hedgehog signaling cascade in a mouse embryonic model of fetal alcohol syndrome. The Journal of craniofacial surgery 2005, 16(6):1055-1061, discussion 1062-1053. 21. Poggi SH, Goodwin K, Hill JM, Brenneman DE, Tendi E, Schinelli S, Abebe D, Spong CY: The role of activity-dependent neuroprotective protein in a mouse model of fetal alcohol syndrome. Am J Obstet Gynecol 2003, 189(3):790-793. 22. Xu Y, Xiao R, Li Y: Effect of ethanol on the development of visceral yolk sac. Hum Reprod 2005, 20(9):2509-2516. 23. Xu Y, Chen X, Li Y: Ercc6l, a gene of SNF2 family, may play a role in the teratogenic action of alcohol. Toxicol Lett 2005, 157(3):233-239. 24. Lee IJ, Soh Y, Song BJ: Molecular characterization of fetal alcohol syndrome using mRNA differential display. Biochem Biophys Res Commun 1997, 240(2):309-313. 25. Hard ML, Abdolell M, Robinson BH, Koren G: Gene-expression analysis after alcohol exposure in the developing mouse. J Lab Clin Med 2005, 145(1):47-54. 26. Miller MW, Mooney SM, Middleton FA: Transforming growth factor beta1 and ethanol affect transcription and translation of genes and proteins for cell adhesion molecules in B104 neuroblastoma cells. J Neurochem 2006, 97(4):1182-1190. 27. Green ML, Singh AV, Zhang Y, Nemeth KA, Sulik KK, Knudsen TB: Reprogramming of genetic networks during initiation of the Fetal Alcohol Syndrome. Dev Dyn 2007, 236(2):613-631. 28. Da Lee R, Rhee GS, An SM, Kim SS, Kwack SJ, Seok JH, Chae SY, Park CH, Yoon HJ, Cho DH, et al: Differential gene profiles in developing embryo and fetus after in utero exposure to ethanol. J Toxicol Environ Health A 2004, 67(23-24):2073-2084. 29. Ogawa T, Kuwagata M, Ruiz J, Zhou FC: Differential teratogenic effect of alcohol on embryonic development between C57BL/6 and DBA/2 mice: a new view. Alcohol Clin Exp Res 2005, 29(5):855-863. Page 16 of 17 30. Cockroft D: Dissection and culture of postimplantation embryos. In Postimplantaion Mammalian Embryos: A Practice Approach. Edited by: AC, DC. New Yolk: Oxford University Press; 1990:15-40. 31. New DA: Whole-embryo culture and the study of mammalian embryos during organogenesis. Biol Rev Camb Philos Soc 1978, 53(1):81-122. 32. Boehm SL, Lundahl KR, Caldwell J, Gilliam DM: Ethanol teratogenesis in the C57BL/6J, DBA/2J, and A/J inbred mouse strains. Alcohol 1997, 14(4):389-395. 33. Gilliam DM, Irtenkauf KT: Maternal genetic effects on ethanol teratogenesis and dominance of relative embryonic resistance to malformations. Alcohol Clin Exp Res 1990, 14(4):539-545. 34. Liu Y, Balaraman Y, Wang G, Nephew KP, Zhou FC: Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation. Epigenetics 2009, 4(7). 35. Vickers MA, Hoy T, Lake H, Kyoizumi S, Boyse J, Hewitt M: Estimation of mutation rate at human glycophorin A locus in hematopoietic stem cell progenitors. Environmental and molecular mutagenesis 2002, 39(4):333-341. 36. Yenerel MN, Sundell IB, Weese J, Bulger M, Gilligan DM: Expression of adducin genes during erythropoiesis: a novel erythroid promoter for ADD2. Experimental hematology 2005, 33(7):758-766. 37. Ortega F, Gonzalez M, Moro MJ, Gascon A, Duarte I, Martin M, Hernandez J, Jimenez-Galindo R, Portero JA, Sanz M, et al: [Prognostic effect of beta 2-microglobulin in multiple myeloma]. Medicina clinica 1992, 99(17):645-648. 38. Mzhel’skaya TI: Biological functions of ceruloplasmin and their deficiency caused by mutation in genes regulating copper and iron metabolism. Bulletin of experimental biology and medicine 2000, 130(8):719-727. 39. Barnes G, Frieden E: Ceruloplasmin receptors of erythrocytes. Biochem Biophys Res Commun 1984, 125(1):157-162. 40. Jiang J, Ng HH: TGFbeta and SMADs talk to NANOG in human embryonic stem cells. Cell Stem Cell 2008, 3(2):127-128. 41. Wilkemeyer MF, Chen SY, Menkari CE, Sulik KK, Charness ME: Ethanol antagonist peptides: structural specificity without stereospecificity. J Pharmacol Exp Ther 2004, 309(3):1183-1189. 42. Chen SY, Charness ME, Wilkemeyer MF, Sulik KK: Peptide-mediated protection from ethanol-induced neural tube defects. Dev Neurosci 2005, 27(1):13-19. 43. Zhou FC, Sari Y, Powrozek T, Goodlett CR, Li T-K: Moderate alcohol exposure compromises neural tube midline development in prenatal brain. Developmental Brain Research 2003, 144:43-55. 44. Bookstein FL, Sampson PD, Connor PD, Streissguth AP: Midline corpus callosum is a neuroanatomical focus of fetal alcohol damage. Anat Rec 2002, 269(3):162-174. 45. Sowell ER, Mattson SN, Thompson PM, Jernigan TL, Riley EP, Toga AW: Mapping callosal morphology and cognitive correlates: Effects of heavy prenatal alcohol exposure. Neurology 2001, 57(2):235-244. 46. Eriksen JL, Gillespie RA, Druse MJ: Effects of in utero ethanol exposure and maternal treatment with a 5-HT(1A) agonist on S100B-containing glial cells. Brain Res Dev Brain Res 2000, 121(2):133-143. 47. Coulter CL, Leech RW, Schaefer GB, Scheithauer BW, Brumback RA: Midline cerebral dysgenesis, dysfunction of the hypothalamic-pituitary axis, and fetal alcohol effects. Arch Neurol 1993, 50(7):771-775. 48. Sulik KK, Johnston MC, Daft PA, Russell WE, Dehart DB: Fetal alcohol syndrome and DiGeorge anomaly: critical ethanol exposure periods for craniofacial malformations as illustrated in an animal model. Am J Med Genet Suppl 1986, 2:97-112. 49. Johnson VP, Swayze VW, Sato Y, Andreasen NC: Fetal alcohol syndrome: craniofacial and central nervous system manifestations. Am J Med Genet 1996, 61(4):329-339. 50. Zhou FC, Sari Y, Powrozek T, Goodlett CR, Li TK: Moderate alcohol exposure compromises neural tube midline development in prenatal brain. Brain Res Dev Brain Res 2003, 144(1):43-55. 51. Kele J, Simplicio N, Ferri AL, Mira H, Guillemot F, Arenas E, Ang SL: Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons. Development 2006, 133(3):495-505. 52. Lee J, Wu Y, Qi Y, Xue H, Liu Y, Scheel D, German M, Qiu M, Guillemot F, Rao M, et al: Neurogenin3 participates in gliogenesis in the developing vertebrate spinal cord. Dev Biol 2003, 253(1):84-98. 53. Korzh V, Sleptsova I, Liao J, He J, Gong Z: Expression of zebrafish bHLH genes ngn1 and nrd defines distinct stages of neural differentiation. Dev Dyn 1998, 213(1):92-104.