Fumagalli et al. BMC Cancer 2010, 10:101 http://www.biomedcentral.com/1471-2407/10/101 Page 5 of 14 Table 1 Mutations detected with OncoCarta ABL1-G250E EGFR-L747_E749del, A750P KIT-P585P ABL1-Q252H EGFR-E746_A750del KIT-D579del ABL1-Y253H EGFR-L747_E749del, A750P KIT-K642E ABL1-Y253F EGFR-L747_S752del, P753S KIT-D816V ABL1-E255K EGFR-E746_T751del, V ins KIT-D816H/D816Y ABL1-E255V EGFR-L747_S752del, Q ins KIT-V825A ABL1-D276G EGFR-L747_S752del, Q ins KIT-E839K ABL1-F311L EGFR-E746_T751del, S752D/SNP C2255T KIT-M552L ABL1-T315I EGFR-D770_N771>AGG/V769_D770insASV/V769_D770insASV KIT-Y568D ABL1-F317L EGFR-D770_N771insG KIT-F584S ABL1-M351T EGFR-L747_T750del, P ins KIT-P551_V555del ABL1-E355G EGFR-E746_A750del KIT-P551_V555del ABL1-F359V EGFR-E746_T751del, I ins KIT-Y553_Q556del ABL1-H396R EGFR-L747_T751del KIT-Y553_Q556del AKT1-rs11555435 EGFR-L747_T751del KRAS-G12V/A/D/C/S/R/F AKT1-rs11555431 EGFR-E746_A750del, V ins KRAS-G13C/S/V/D AKT1-rs11555432 EGFR-E746_A750del, V ins KRAS-A59T AKT1-rs12881616 EGFR-S752_I759del KRAS-Q61E/K/L/R/P/H AKT1-rs11555433 ERBB2-L755P MET-R970C AKT1-rs11555436 ERBB2-G776S/G776LC MET-T992I AKT1-rs34409589 ERBB2-G776VC MET-Y1230C AKT2-S302G ERBB2-G776VC/G776VC MET-Y1235D AKT2-R371H ERBB2-M774_A775insYVMA MET-M1250T BRAF-G464R ERBB2-A775_G776insYVMA NRAS-G12V/G12A/G12D BRAF-G464V/G464E ERBB2-P780_Y781insGSP NRAS-G12C/G12R/G12S BRAF-G466V/G466G/G466E ERBB2-P780_Y781insGSP NRAS-G13V/G13A/G13D BRAF-G466R ERBB2-S779_P780insVGS NRAS-G13C/G13R/G13S BRAF-F468C FGFR1-S125L NRAS-A18T BRAF-G469S/E/A/V/R FGFR1-P252T NRAS-Q61L/Q61R/Q61P BRAF-D594V| G FGFR3-R248C NRAS-Q61H BRAF-F595L FGFR3-S249C NRAS-Q61E/Q61K BRAF-G596R FGFR3-G370C PDGFRA-V561D BRAF-L597S/R/Q/V FGFR3-Y373C PDGFRA-T674I BRAF-T599I FGFR3-A391E PDGFRA-F808L BRAF-V600E/K/R/L FGFR3-K650Q/E PDGFRA-D846Y BRAF-K601N/E FGFR3-K650T/M PDGFRA-N870S CDK-R24C/H FLT3-I836del PDGFRA-D1071N EGFR-R108K FLT3_2 PDGFRA-D842_H845del EGFR-T263P FLT3_3 PDGFRA-I843_D846del EGFR-A289V FLT3-D835H/D835Y PDGFRA-S566_E571>K EGFR-G598V HRAS-G12V/D PDGFRA-I843_S847>T EGFR-E709K/E709H HRAS-G13C/R/S PDGFRA-D842V EGFR-E709A/E709G/E709V HRAS-G13V/D PIK3CA-R88Q EGFR-G719S/G719C HRAS-Q61H PIK3CA-N345K EGFR-G719A HRAS-Q61H/L/R/P/K PIK3CA-C420R EGFR-M766_A767insAI JAK2-V617F PIK3CA-P539R EGFR-S768I KIT-D52N PIK3CA-E542K EGFR-V769_D770insASV KIT-Y503_F504insAY PIK3CA-E545K EGFR-V769_D770insCV KIT-W557R/W557R/W557G PIK3CA-Q546K EGFR-D770_N771>AGG/V769_D770insASV/V769_D770insASV KIT-V559D/V559A/V559G PIK3CA-H701P EGFR-D770_N771insG KIT-V559I PIK3CA-H1047R/H1047L EGFR-N771_P772>SVDNR KIT-V560D/V560G PIK3CA-H1047Y