Lin et al. BMC Public Health 2010, 10:747 http://www.biomedcentral.com/1471-2458/10/747 syndrome: data from the NHANES-II mortality follow-up. J Natl Med Assoc 2008, 100:565-571. 22. Adam FM, Nara MG, Adam JM: Fasting insulin, adiponectin, hs-CRP levels, and the components of metabolic syndrome. Acta Med Indones 2006, 38:179-184. 23. Schultz AB, Edington DW: The association between changes in metabolic syndrome and changes in cost in a workplace population. J Occup Environ Med 2009, 51:771-779. 24. Goldbeter A: A model for the dynamics of human weight cycling. J Biosci 2006, 31:129-136. 25. Cheriyath P, Duan Y, Qian Z, Nambiar L, Liao D: Obesity, physical activity and the development of metabolic syndrome: the Atherosclerosis Risk in Communities study. Eur J Cardiovasc Prev Rehabil 2010, 17:309-313. 26. Saely CH, Vonbank A, Rein P, Woess M, Beer S, Aczel S, Jankovic V, Boehnel C, Risch L, Drexel H: Alanine aminotransferase and gamma- glutamyl transferase are associated with the metabolic syndrome but not with angiographically determined coronary atherosclerosis. Clin Chim Acta 2008, 397:82-86. 27. Sun JH, See LC, Hsu WC, Tsai JS, Lin JD: Hyperinsulinemia and insulin resistance related metabolic syndrome. Chang Gung Med J 2001, 24:11-18. 28. Kim CH, Younossi ZM: Nonalcoholic fatty liver disease: a manifestation of the metabolic syndrome. Cleve Clin J Med 2008, 75:721-728. 29. van den Hooven C, Ploemacher J, Godwin M: Metabolic syndrome in a family practice population: prevalence and clinical characteristics. Can Fam Physician 2006, 52:982-983. 30. Valsamakis G, Jones A, Chetty R, McTernan PG, Boutsiadis A, Barnett AH, Banerjee AK, Kumar S: MRI total sagittal abdominal diameter as a predictor of metabolic syndrome compared to visceral fat at L4-L5 level. Curr Med Res Opin 2008, 24:1853-1860. 31. Xu A, Tso AW, Cheung BM, Wang Y, Wat NM, Fong CH, Yeung DC, Janus ED, Sham PC, Lam KS: Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5- year prospective study. Circulation 2007, 115:1537-1543. 32. Bo S, Rosato R, Ciccone G, Gambino R, Durazzo M, Gentile L, Cassader M, Cavallo-Perin P, Pagano G: What predicts the occurrence of the metabolic syndrome in a population-based cohort of adult healthy subjects? Diabetes Metab Res Rev 2009, 25:76-82. 33. Holvoet P, Lee DH, Steffes M, Gross M, Jacobs DR Jr: Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndrome. JAMA 2008, 299:2287-2293. 34. Irace C, Cortese C, Fiaschi E, Carallo C, Sesti G, Farinaro E, Gnasso A: Components of the metabolic syndrome and carotid atherosclerosis: role of elevated blood pressure. Hypertension 2005, 45:597-601. 35. Tomiyama H, Hashimoto H, Hirayama Y, Yambe M, Yamada J, Koji Y, Shiina K, Yamamoto Y, Yamashina A: Synergistic acceleration of arterial stiffening in the presence of raised blood pressure and raised plasma glucose. Hypertension 2006, 47:180-188. 36. Hong Y, Jin X, Mo J, Lin HM, Duan Y, Pu M, Wolbrette DL, Liao D: Metabolic syndrome, its preeminent clusters, incident coronary heart disease and all-cause mortality–results of prospective analysis for the Atherosclerosis Risk in Communities study. J Intern Med 2007, 262:113-122. 37. Mujica V, Urzua A, Leiva E, Diaz N, Moore-Carrasco R, Vasquez M, Rojas E, Icaza G, Toro C, Orrego R, Palomo I: Intervention with education and exercise reverses the metabolic syndrome in adults. J Am Soc Hypertens 2010, 4:148-153. 38. Makaryus AN, Akhrass P, McFarlane SI: Treatment of hypertension in metabolic syndrome: implications of recent clinical trials. Curr Diab Rep 2009, 9:229-237. 39. Athyros VG, Kakafika AI, Papageorgiou AA, Paraskevas KI, Tziomalos K, Anagnostis P, Pagourelias E, Koumaras C, Karagiannis A, Mikhailidis DP: Effects of statin treatment in men and women with stable coronary heart disease: a subgroup analysis of the GREACE Study. Curr Med Res Opin 2008, 24:1593-1599. 40. Lundgren JD, Malcolm R, Binks M, O’Neil PM: Remission of metabolic syndrome following a 15-week low-calorie lifestyle change program for weight loss. Int J Obes (Lond) 2009, 33:144-150. Page 8 of 8 Pre-publication history The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2458/10/747/prepub doi:10.1186/1471-2458-10-747 Cite this article as: Lin et al.: Worksite health screening programs for predicting the development of Metabolic Syndrome in middle-aged employees: a five-year follow-up study. BMC Public Health 2010 10:747. Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color ﬁgure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit