BMC Genomics 2004, 5:46 http://www.biomedcentral.com/1471-2164/5/46 RFeiglautrivee1functional clustering of genes differentially regulated in LAPE cells Relative functional clustering of genes differentially regulated in LAPE cells. Percentage of genes in the indicated functional categories that were regulated (A), had increased expression (B), and decreased expression in LAPE cells compared with LAPN cells (p < 0.05, n = 5). C/EBP family, was confirmed by TaqMan analysis (Fig. 2D). GADD153 dimerizes with other C/EBP isomers to inhibit their binding to C/EBP binding sites in the pro- moters of a number of genes involved in differentiation and mitogenesis [32,33]. Expression of GADD153 increases in response to DNA damage [34], and oxidative stress [35,36], hence its role in cell cycle progression is also included in Figure 3. Page 3 of 13 (page number not for citation purposes)