Lo et al. BMC Cancer 2012, 12:235 http://www.biomedcentral.com/1471-2407/12/235 Page 7 of 13 Figure 1 Pie chart of significantly altered biological processes in Asian (A) and Caucasian (B) lung cancer patients. The data were analyzed by DAVID bioinformatics resources. The common biological processes in both Asian and Caucasian marked with asterisk (*). pathways (see Additional file 5: Table S4). Second, the candidate genes analyzed with MetaCore were further integrated with the expression array for Asian lung can- cer patients (GEO database with accession number GSE21933) and the gene expression database of the Na- tional Cancer Institute's Cancer Genome Anatomy Pro- ject (http://cgap.nci.nih.gov) for Caucasian lung cancer patients (see Additional file 5: Table S4). We found 134 genes showing correlation between DNA copy number and mRNA expression patterns by integrating our array- CGH database with the expression array databases (Table 4). Finally, we performed literature search and selected 54 novel lung cancer candidate genes which have not been reported to be altered in lung cancer. In the current study, we validated four genes based on their novelty and antibody availability. These four genes were ARHGAP19 on 10q24.1 functioning in Rho activity control, FRAT2 on 10q24.1 involved in Wnt signaling, PAFAH1B1 on 17p13.3 functioning in motility control, and ZNF322A on 6p22.1 involved in MAPK pathway