BMC Genomics 2009, 10(Suppl 3):S24 http://www.biomedcentral.com/1471-2164/10/S3/S24 13. Suptawiwat O, Kongchanagul A, Chan-It W, Thitithanyanont A, Wiriyarat W, Chaichuen K, Songserm T, Suzuki Y, Puthavathana P and Auewarakul P: A simple screening assay for receptor switching of avian influenza viruses. J Clin Virol 2008, 42:186–189. 14. Puthavathana P, Auewarakul P, Charoenying PC, Sangsiriwut K, Pooruk P, Boonnak K, Khanyok R, Thawachsupa P, Kijphati R and Sawanpanyalert P: Molecular characterization of the complete genome of human influenza H5N1 virus isolates from Thailand. J Gen Virol 2005, 86:423–433. 15. Xu D, Newhouse EI, Amaro RE, Pao1 HC, Cheng LS, Markwick PRL, McCammon JA, Li WW and Arzberger PW: Distinct Glycan Topology for Avian and Human Sialopentasaccharide Receptor Analogues upon Binding Different Hemaggluti- nins: A Molecular Dynamics Perspective. J Mol Biol 2009, 387:465–491. 16. Gamblin SJ, Haire LF, Russell RJ, Stevens DJ, Xiao B, Ha Y, Vasisht N, Steinhauer DA, Daniels RS, Elliot A, Wiley DC and Skehel JJ: The structure and receptor binding properties of the 1918 influenza hemagglutinin. Science 2004, 303:1838–1842. 17. An Automated Comparative Protein Modelling Server. http://swissmodel.expasy.org/. 18. Harvey R, Matin CRA, Zambon M and Barclay SW: Restrictions to the Adaptation of Influenza A Virus H5 Hemagglutinin to the Human Host. J Virol 2004, 78:502–507. 19. Auewarakul P, Suptawiwat O, Kongchanagul A, Sangma C, Suzuki Y, Ungchusak K, Louisirirotchanakul S, Lerdsamran H, Pooruk P, Thitithanyanont A, Eiamudomkan A, Pittayawonganon C, Guo C-T, Hiramatsu H, Jampangern W, Chunsutthiwat S and Puthavathana P: An avian influenza H5N1 virus that binds to human-type receptor. J Virol 2007, 81:9950–9955. 20. GLYCAM force field parameters. http://glycam.ccrc.uga.edu. 21. Mahoney MW and Jorgenson W: A five-site model for liquid water and the reproduction of the density anomaly by rigid, nonpolarizable potential functions. J Chem Phys 2000, 112:8910–8922. 22. Rychaert J-P, Ciccotti G and Berendsen HJC: Numerical integra- tion of the Cartesian equations of motion of a system with constraints: Molecular dynamics of n-alkanes. J Comput Phys 1997, 23:327–341. 23. Case DA, Darden TA, Cheatham TE III, Simmerling CL, Wang J, Duke RE, Luo R, Merz KM, Pearlman DA, Crowley M, Walker RC, Zhang W, Wang B, Hayik S, Roitberg A, Seabra G, Wong KF, Paesani F, Wu X, Brozell S, Tsui V, Gohlke H, Yang L, Tan C, Mongan J, Hornak V, Cui G, Beroza P, Mathews DH, Schafmeister C, Ross WS and Kollman PA: AMBER 9 University of California, San Francisco; 2006. 24. WYSIWYG 2D plotting tool. http://plasma-gate.weizmann.ac.il/ Grace/. 25. Humphrey W, Dalke A and Schulten K: VMD - Visual Molecular Dynamics. J Molec Graphics 1996, 14:33–38. 26. Lieth von der C-W and Kozar T: Towards a better semiquanti- tative estimation of binding constants: molecular dynamics exploration of the conformational behavior of isolated sialyllactose and sialyllactose complexed with influenza A hemagglutinin. J Mol Struct (Theochem) 1996, 368:213–222. 27. Frank M and Lieth von der C-W: Comparison of the Conforma- tional Behavior of Sialyllactose Complexed with the two Viral Attachment Proteins Influenza A Hemagglutinin and the Murine Polyomavirus. J Mol Model 1997, 3:408–414. 28. Kasson PM and Pande VS: Structural Basis for Influence of Viral Glycans on Ligand Binding by Influenza Hemagglutinin. Biophys J 2008, 95:L48–L50. 29. Sangma C, Nunrium P and Hannongbua S: The Analysis of Binding Patterns on Different Receptors Bound to Hemagglutinin of Avian and Avian-like Influenza Virus Using Quantum Chemical Calculations. J Theor and Comp Chem 2006, 5:753–768. Publish with Bio Med Central and every scientist can read your work free of charge "BioMed Central will be the most significant development for disseminating the results of biomedical research in our lifetime." Sir Paul Nurse, Cancer Research UK Your research papers will be: available free of charge to the entire biomedical community peer reviewed and published immediately upon acceptance cited in PubMed and archived on PubMed Central yours — you keep the copyright Submit your manuscript here: http://www.biomedcentral.com/info/publishing_adv.asp BioMedcentral Page 9 of 9 (page number not for citation purposes)