Deutscher et al. BMC Cancer 2010, 10:519 http://www.biomedcentral.com/1471-2407/10/519 Page 4 of 7 Figure 1 Median values for TF (A) and Tn (B). H = usual hyperplasia; AH = atypical hyperplasia; DCIS: ductal carcinoma in situ; invasive: invasive breast cancer. Numbers in parentheses indicate the sample sizes for each group. Y axis units are Abs/μL. TF expression was higher in women with AH compared to H (p = .043), and trended higher in women with DCIS compared to normals (p = .07) and women with H (p = .09). Logistic regression Logistic regression was conducted involving TF, Tn, and age for the following predictive groups: cancer vs. no cancer, cancer vs. benign pathology, and abnormal vs. benign pathology (Table 2). Each of these models demonstrates that in post- but not premenopausal women, high TF (odds ratios (OR) ranging from 8.53- 15.56) and increasing age are independent predictors of disease (p < .05), whereas Tn concentration was not an independent predictor of disease status. ROC curves We generated ROC curves to determine how well infor- mation on TF, Tn and age predicted if a postmenopau- sal woman had breast atypia or cancer. Three comparisons: cancer vs. no cancer, cancer vs. benign pathology, and abnormal vs. benign pathology were conducted. The AUC values for the three comparisons were similar, ranging from .81 - .83, with the latter two comparisons having the best predictive ability (Figures 2A-C).