BMC Cancer 2008, 8:270 http://www.biomedcentral.com/1471-2407/8/270 Table 1: Genes mediating focal adhesion and cytoskeletal activity that differ significantly (P ≤ 0.05) in their expression levels between carcinoma and papillary adenocarcinoma tumors. Systematic name Comparative expression Common name Description 1448346_at 1417752_at 1452651_a_at 1448394_at 1427769_x_at 1449551_at 1450650_at 1422544_at 1423049_a_at 1449577_x_at 1425028_a_at 1449997_at 1449996_a_at 1450813_a_at 1419606_a_at 1418884_x_at 1416311_s_at 1426427_at 1424768_at 1417366_s_at 1426098_a_at 1423058_at 1423057_at 1434036_at 1423588_at 1436722_a_at 1427735_a_at 1456473_x_at 1416459_at 1437331_a_at 1423973_a_at 1421789_s_at 1418822_a_at 1424307_at 1426952_at 1417225_at 1424021_at 1435559_at 1422536_at 1438608_at 1434588_x_at 1447964_at 1452193_a_at 1434074_x_at 1431429_a_at car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap car > pap pap > car pap > car pap > car pap > car pap > car pap > car pap > car pap > car Cfl1 Coro1c Myl1 Myl2 Myl3 Myo1c Myo10 Myo10 Tpm1 Tpm2 Tpm2 Tpm3 Tpm3 Tnni1 Tnnt1 Tuba1 Tuba7 Ttll1 Cald1 Calm1 Cast Capza2 Capza2 Mtss1 Arpc4 Actb Acta1 Arf2 Arf2 Arf3 Arf3 Arf3 Arf6 Arhgap1 Arhgap18 Arl6ip5 Arl6ip6 BC029719 Tnni3 Tnni2 Tbca Ttl Wasl Arf4 Arl4 cofilin 1, non-muscle coronin, actin-binding protein 1C myosin, light polypeptide 1, alkali; atrial, embryonic myosin, light polypeptide 2, regulatory, cardiac, slow myosin, light polypeptide 3, alkali; ventricular, skeletal, slow myosin IC myosin X myosin X tropomyosin 1, alpha tropomyosin 2, beta tropomyosin 2, beta tropomyosin 3, gamma tropomyosin 3, gamma troponin I, skeletal, slow 1 troponin T1, skeletal, slow tubulin, alpha 1 tubulin, alpha 7 tubulin tyrosine ligase-like 1 caldesmon 1 calmodulin 1 calpastatin capping protein (actin filament) muscle Z-line, alpha 2 capping protein (actin filament) muscle Z-line, alpha 2 metastasis suppressor 1 actin-related protein 2/3 complex, subunit 4 actin, beta, cytoplasmic actin, alpha 1, skeletal muscle ADP-ribosylation factor 2 ADP-ribosylation factor 2 ADP-ribosylation factor 3 ADP-ribosylation factor 3 ADP-ribosylation factor 3 ADP-ribosylation factor 6 Rho GTPase-activating protein 1 Rho GTPase-activating protein 18 ADP-ribosylation factor-like 6 interacting protein 5 ADP-ribosylation factor-like 6 interacting protein 6 myosin VI troponin I, cardiac 3 troponin I, skeletal, fast 2 tubulin cofactor a tubulin tyrosine ligase Wiskott-Aldrich syndrome-like (human) ADP-ribosylation factor 4 ADP-ribosylation factor-like 4 glands. In the lactating gland, β-catenin was located in the nuclei of 40 ± 5.5% of the epithelial cells (Figure 6Ba). A higher number of cells exhibiting visible levels of nuclear β-catenin were observed in the carcinoma tumors (81 ± 2.4% of the cell population, Figure 6Bb). In contrast, the papillary adenocarcinoma sections were almost com- pletely devoid of detectable nuclear β-catenin: it was detected in the nuclei of only 0.3 ± 0.1% of the cells, but was highly expressed in the cytoplasm (Figure 6Bc). The Notch system plays a predominant role in breast can- cer and interacts with other pathways, including the Wnt- signaling pathway [33,34]. Notch signaling is triggered by the binding of one of five different membrane-bound lig- ands to one of the Notch proteins on neighboring cells. This interaction leads to its proteolitic cleavage and release of the Notch intracellular domain (NICD), which translocates into the nucleus to activate gene transcrip- tion. In our analysis, Notch 1 expression was significantly Page 12 of 19 (page number not for citation purposes)