Ji et al. BMC Genomics 2012, 13:441 http://www.biomedcentral.com/1471-2164/13/441 Abbreviations VLDL: Very low density lipoprotein; CEBPα :CCAAT: Enhancer-binding protein alpha; PPAR: Peroxisome proliferator-activated receptor; IRβ: Insulin receptor β-subunit; IRS-1: Insulin receptor substrate-1; Shc: Src homology 2 domain- containing substrate; PI3K: Phosphatidylinositol 3-kinase; QPCR: Quantitative PCR; FDR: False discovery rate; GO: Gene ontology; PDGF: Platelet derived growth factor; MSC: Mesenchymal stem cell; Camp: Cyclic adenosine monophosphate; DGAT2: Diacylglycerol O-acyltransferase homolog 2; PDK4: Dehydrogenase kinase 4; ACBD5: Acyl-Coenzyme A binding domain containing 5; AGTR1: Type I angiotensin II receptor; PUFA: Polyunsaturated fatty acids; NEFA: Non-esterified fatty acid; ATGL: Adipose triglyceride lipase; PD: Pyruvate dehydrogenase; LXR: Liver X receptor; GCG: Preproglucagon; PGB: Preproglucagon class B transcript; BCAAs: Branched chain amino acids. Competing interests The authors declare that they have no competing interests. Authors’ contributions BJ performed the experimental assays, analyzed genomic data and drafted the manuscript. BE, JG and SC generated and analyzed metabolomics data. SD provided technical support and AM provided statistical support. JS, SM-C and JD performed the original in vivo study and provided tissue samples. BV designed and supervised the study and personnel and edited the manuscript. All authors read and approved the final manuscript. Author details 1Department of Animal Science, University of Tennessee, Knoxville, Tennessee, USA. 2Department of Chemistry, University of Tennessee, Knoxville, Tennessee, USA. 3Unité de Recherches Avicoles (U83), Institut National de la Recherche Agronomique (INRA), Nouzilly 37380, France. 4Unité de Physiologie de la Reproduction et des Comportements (UMR85), Institut National de la Recherche Agronomique (INRA), Nouzilly 37380, France. 5201E McCord Hall, Morgan Circle Dr. Knoxville, Tennessee 2640, USA. Received: 23 December 2011 Accepted: 25 August 2012 Published: 31 August 2012 References 1. Burt DW: The chicken genome. Genome Dyn 2006, 2:123–137. 2. Hillier LW, Miller W, Birney E, Warren W, Hardison RC, Ponting CP, Bork P, Burt DW, Groenen MAM, Delany ME, Dodgson JB, Chinwalla AT, Cliften PF, Clifton SW, Delehaunty KD, Fronick C, Fulton RS, Graves TA, et al: Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution. 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