BMC Cancer 2007, 7:226 http://www.biomedcentral.com/1471-2407/7/226 VFisguuarlieza6tion of single case aberration patterns in 123 carcinomas with gain on 11q13 and concomitant proximal loss Visualization of single case aberration patterns in 123 carcinomas with gain on 11q13 and concomitant proximal loss. Cases are clustered according to their imbalance patterns (gain/loss status, 320 bands resolution). subgroup detection from large, heterogeneous series of CGH data [85,86]. This is especially challenging regarding the variant background of chromosomal copy number changes found in certain tumor types, which may be based on aberrant expression of regulatory genes [41]. Since genomic copy number changes constitute only one of many mechanisms leading to aberrant gene regulation, the deduction of oncogenetic pathways from CGH data will remain a challenging project. However, the combina- tion of existing large-scale data collections and current high resolution screening techniques should provide additional pieces for these puzzles. For that purpose, the Progenetix data collection is open for inclusion into data mining projects. Competing interests The author(s) declare that they have no competing inter- ests. Authors' contributions MB designed the study, assembled the data collection, performed the data analysis and wrote the manuscript. Additional material Additional file 1 Supplementary figures. The file contains imbalance histograms for each of the different clinico-pathological entities and additional box plots depict- ing the number of aberrant chromosomes per entity and histological sub- set. Click here for file [http://www.biomedcentral.com/content/supplementary/1471- 2407-7-226-S1.pdf] Acknowledgements I am indebted to the authors of a number of articles, who provided the data for the database that otherwise would not have been accessible. Progenetix database contributors are listed on the project's website [25]. During a part Page 12 of 15 (page number not for citation purposes)