Taglietti et al. Journal of Medical Case Reports 2010, 4:332 http://www.jmedicalcasereports.com/content/4/1/332 Authors’ contributions FT monitored the patient during hospitalization, analyzed data from the literature, and helped to write the article. FDN, AB and LF performed the histologic examination of the liver biopsy. ST performed the liver biopsy. EG was the major contributor in writing the manuscript. AC and PC performed the follow-up consultations of the patient after discharge. NP reviewed the manuscript. All authors read and approved the final manuscript Competing interests The authors declare that they have no competing interests. Received: 16 March 2010 Accepted: 21 October 2010 Published: 21 October 2010 References 1. Chobanian AV, Bakris GL, Black HR, et al: The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. JAMA 2003, 289:2560-72. 2. Goodman & Gilman’s The Pharmacologic Basis of Therapeutics. Edited by: Brunton L, Lazo J, Parker K , 11 2006. 3. Rosenberg L, Shapiro S, Slone D, et al: Thiazides and acute cholecystitis. N Engl J Med 1980, 303:546-548. 4. Bourke JB, Langman MJ: Thiazide, diuretics, cholecystitis, and pancreatitis. N Engl J Med 1981, 304:233-4. 5. Porter JB, Jick H, Dinan BJ: Acute cholecystitis and thiazides. New Engl J Med 1981, 304:954-955. 6. Van der Linden W, Ritter B, Edlund G: Acute cholecystitis and thiazides. Br Med J (Clin Res Ed) 1984, 289:654-5. 7. Angelin B: Effect of thiazide treatment on biliary lipid composition in healthy volunteers. Eur J Clin Pharmacol 1989, 37:95-6. 8. Wilcox CS, Welch WJ, Shreiner GF, Belardinelli L: Natriuretic and diuretic actions of a highly selective A1 receptor antagonist. J Am Soc Nephrol 1999, 10:714-720. 9. Arizon Z, Alexander P, Berner Y: Hydrochlorothiazide induced hepato- cholestatic liver injury. Age and Aging 2004, 33:509-510. 10. Naranjo CA, Busto U, Sellers EM, et al: A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981, 30:239-245. 11. Eriksson JW, Jansson PA, Carlberg B, Hagg A, et al: Hydrochlorothiazide, but not candesartan, aggravates insulin resistance and causes visceral and hepatic fat accumulation. Hypertension 2008, 52:1030. 12. Kaihara M, Nakamura Y, Sugimoto T, Uchida HA, Norii H, Hanajama Y, Makino H: Olmesartan and tenocapril prevented the development of hyperglycemia and the deterioration of pancreatic islet morphology in Otsuka-Lory-Evans-Tokushima fatty rats. Acta Med Okayama 2009, 63(1):35-41. doi:10.1186/1752-1947-4-332 Cite this article as: Taglietti et al.: Acute hepatocellular and cholestatic injury during therapy with hydrochlorothiazide - clinicohistopathologic findings: a case report. Journal of Medical Case Reports 2010 4:332. Page 4 of 4 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color ﬁgure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit