BMC Cancer 2004, 4 http://www.biomedcentral.com/1471-2407/4/9 Table 3: Cumulative breast cancer risk ratios to age 50 and to age 70 by genotype among 2430 first degree female relatives of breast cancer cases (probands), 190 of whom were reported to have breast cancer Rare allele frequency N** To age 50 RR 95% CI p-value N** To age 70 RR 95% CI Polymorphism* Base excision repair genes XRCC1 R194W RR RW or WW XRCC1 R280H RR RH or HH XRCC1 R399Q RR RQ QQ APEX Q51H QQ QH or HH APEX D148E DD DE EE POLD1 R119H RR RH or HH BRCA1 interacting proteins BRCA2 N289H MM NH or HH BRCA2 N372H NN NH HH BRCA2 T1915M TT TM or MM BRIP1 -64 G>A GG GA AA BRIP1 P919S PP PS SS ZBRK1 L66P LL LP or PP ZBRK1 S472P SS SP or PP ZBRK1 R501S RR RS or SS ZBRK1 1845 C>T CC CT or TT Growth factor genes TGFß1 L10P LL LP or PP TGFß1 P25R 0.06 0.03 0.37 0.04 0.49 0.06 0.03 0.32 0.05 0.46 0.43 0.15 0.12 0.12 0.06 0.38 0.10 51 6 52 5 21 22 14 49 7 20 27 9 44 13 57 0 30 23 4 53 4 17 24 16 10 34 12 43 14 55 2 46 11 45 12 25 31 1.0 1.4 1.0 0.7 1.0 0.7 3.4 1.0 3.0 1.0 0.2 0.8 1.0 2.5 1.0 0 1.0 0.4 1.5 1.0 1.7 1.0 0.4 1.5 1.0 4.5 6.9 1.0 0.9 1.0 0.8 1.0 0.8 1.0 2.2 1.0 0.5 --- 0.4–4.2 --- 0.0–2.4 --- 0.1–2.0 1.3–9.3 --- 0.5–6.7 --- 0.1–0.8 0.2–1.9 --- 0.8–5.0 --- --- --- 0.1–1.3 0.4–4.4 --- 0.0–4.0 --- 0.1–1.2 0.5–4.3 --- 0.8–12.2 1.6–29.3 --- 0.3–2.0 --- 0.0–2.2 --- 0.2–1.8 --- 0.5–4.3 --- 0.2–1.2 0.408 0.736 0.444 0.014 0.216 0.028 0.546 0.106 ---- 0.140 0.322 0.664 0.126 0.424 0.096 0.018 0.712 0.614 0.534 0.218 0.148 125 22 134 13 59 64 24 134 12 49 65 32 123 24 141 6 89 42 16 139 8 42 70 35 52 69 25 108 38 137 10 116 31 121 25 54 92 1.0 2.3 1.0 1.2 1.0 1.1 1.9 1.0 1.7 1.0 0.2 1.0 1.0 1.8 1.0 1.6 1.0 0.2 1.3 1.0 2.1 1.0 0.7 1.6 1.0 0.6 1.3 1.0 1.2 1.0 1.6 1.0 1.2 1.0 1.6 1.0 0.8 --- 1.3–3.8 --- 0.5–2.5 --- 0.4–1.6 1.1–3.9 --- 0.7–3.1 --- 0.1–0.5 0.6–1.7 --- 1.0–2.9 --- 0.5–2.9 --- 0.1–0.5 0.8–2.4 --- 0.6–3.6 --- 0.2–1.2 0.8–2.8 --- 0.3–1.2 0.8–2.8 --- 0.7–1.9 --- 0.6–2.9 --- 0.7–2.1 --- 0.8–2.8 --- 0.5–1.5 p-value 0.004 0.522 0.636 0.010 0.236 <0.001 0.860 0.058 0.370 <0.001 0.232 0.215 0.112 0.218 0.134 0.220 0.304 0.312 0.434 0.162 0.536 Page 8 of 12 (page number not for citation purposes)