BMC Genomics 2004, 5:46 http://www.biomedcentral.com/1471-2164/5/46 pFGhiegonuseprshedo4irffyelaretinotnially regulated in LAPE cells grouped as functioning in glycolysis, electron transport and oxidative Genes differentially regulated in LAPE cells grouped as functioning in glycolysis, electron transport and oxida- tive phosphorylation. A. Schematic diagram of carbohydrate metabolism and oxidative phosphorylation. Red indicates genes with increased expression in LAPE cells compared with LAPN cells, and blue indicates genes with decreased expression. B. Rel- ative TaqMan expression of Glut-4 confirmed GeneChip data of decreased Glut-4 expression in LAPE cells compared with LAPN cells. Data in A represent the means of fold-increase or – decrease in LAPE cells (p < 0.05, n = 5). Data in B are repre- sentative of 2 separate cell preparations. flux and NADH would also be favored by decreased expression of fructose 1,6-bis-phosphate, which limits substrate recycling, and lactate dehydrogenase, which catalyzes the reduction of NADH by pyruvate to yield NAD+ and lactate. An established metabolic difference in oncogenic transformed cells compared with normal cells Page 9 of 13 (page number not for citation purposes)