Lejeune et al. BMC Genomics 2012, 13:91 http://www.biomedcentral.com/1471-2164/13/91 Page 7 of 14 Figure 3 Gene Ontology classification of genes that modulate neuronal dysfunction induced by expanded polyQ expression. Genes were classified based on their functional annotations in the GO categories ‘Biological Process’, ‘Molecular Function’ and ‘Cellular component’. Pie- charts for the most frequent ‘Biological process’ categories (corresponding to at least 18 genes) are shown for gene inactivations that reduced 128Q-neuron dysfunction (A) and those that aggravated neuronal dysfunction (B). The number of genes is indicated. See the indicated supplementary tables (Supplementary Tables 4-5) for the complete lists of genes in each GO category.