BMC Genomics 2009, 10:150 http://www.biomedcentral.com/1471-2164/10/150 12. Sluyter F, Van Oortmerssen GA, de Ruiter AJH, Koolhaas JM: Aggression in wild house mice: current state of affairs. Behav Genet 1996, 26:489-496. 13. Brouillette J, Rivard K, Lizotte E, Fiset C: Sex and strain differ- ences in adult mouse cardiac repolarization: importance of androgens. Cardiovasc Res 2005, 65:148-157. 14. Kanehisa M, Araki M, Goto S, Hattori M, Hirakawa M, Itoh M, et al.: KEGG for linking genomes to life and the environment. Nucleic Acids Res 2008, 36:D480-D484. 15. Young ME, Razeghi P, Taegtmeyer H: Clock genes in the heart: characterization and attenuation with hypertrophy. Circ Res 2001, 88:1142-1150. 16. Gréchez-Casiau A, Rayet B, Guillaumond F, Teboul M, Delaunay F: The circadian clock component BMAL1 is a critical regulator of p21waf1/cip1 expression and hepatocyte proliferation. J Biol Chem 2008, 283:4535-4542. 17. Iwahana E, Karatsoreos I, Shibata S, Silver R: Gonadectomy reveals sex differences in circadian rhythms and suprachiasmatic nucleus androgen receptors in mice. Horm Behav 2008, 53:422-430. 18. Karatsoreos IN, Wang A, Sasanian J, Silver R: A role for androgens in regulating circadian behavior and the suprachisamatic nucleus. Endocrinology 2008, 148:5487-5495. 19. Gurkan E, Olszens KR, Nadeau JH, Loparo KA: Feature identifica- tion in circadian rhythms of mice strains using in vivo infor- mation. Mamm Genome 2008, 19:366-377. 20. Mulholland DJ, Dedhar S, Coetzee GA, Nelson CC: Interaction of nuclear receptors with the Wnt/b-catenin/Tcf signaling axis: Wnt you like to know? Endocr Rev 2005, 26:898-915. 21. Petre-Draviam CE, Cook SL, Burd CJ, Marchall TW, Wetherill YB, Knudsen KE: Specificity of cyclin D1 for androgen receptor co- repressor activity. Cancer Res 2008, 63:4903-4913. 22. Petre CE, Wetherill YB, Danielsen M, Knudsen KE: Cyclin D1: mechanism and consequence of androgen receptor co- repressor activity. J Biol Chem 2002, 277:2207-2215. 23. Ji M, Zhang Q, Ye J, Wang X, Yang W, Zhu D: Myostatin induces p300 degradation to silence cyclin D1 expression through the PI3K/PTEN/Akt pathway. Cell Signal 2008, 20:1452-1458. 24. Li J-M, Brooks G: Downregulation of cyclin-dependent kinase inhibitors p21 and p27 in pressure-overload hypertrophy. Am J Physiol 1997, 273:H1358-H1367. 25. Sharma M, Chuang WW, Sun Z: Phosphatidylinositol 3-kinase/ Akt stimulates androgen pathway through GSKβ inhibition and nuclear β-catenin accumulation. J Biol Chem 2002, 277:30935-30941. 26. Lu S, Liu M, Epner DE, Tsai SY, Tsai MJ: Androgen regulation of the cyclin-dependent kinase inhibitor p21 gene through an androgen response element in the proximal promoter. Mol Endocrinol 1999, 13:376-384. 27. Hsieh AC, Small EJ, Ryan CJ: Androgen-response elements in hormone-refractory prostate cancer: implications for treat- ment development. Lancet Oncol 2007, 8:933-939. 28. Knight-Krajewski S, Welsh CF, Liu Y, Lyons LS, Faysal JM, Yang ES, et al.: Deregulation of the Rho GTPase, Rac1, suppresses cyclin- dependent kinase inhibitor p21(CIP1) levels in androgen- independent human prostate cancer cells. Oncogene 2004, 23:5513-5522. 29. Omar EA, Behlouli H, Chevalier S, Aprikian AG: Relationship of p21(WAF-I) protein expression with prognosis in advanced prostate cancer treated by androgen ablation. Prostate 2001, 49:191-199. 30. Brooks G, Poolman RA, Li JM: Arresting developments in the cardiac myocyte cell cycle: role of cyclin-dependent kinase inhibitors. Cardiovasc Res 1998, 39:301-311. 31. Rohozinski J, Agoulnik AI, Boettger-Tong HL, Bishop CE: Successful targeting of mouse Y chromosome genes using a site- directed insertion vector. Genesis 2002, 32:1-7. 32. Toure A, Grigoriev V, Mahadevaiah SK, Rattigan A, Ojarikre OA, Bur- goyne PS: A protein encoded by a member of the multicopy Ssty gene family located on the long arm of the mouse Y chromosome is expressed during sperm development. Genomics 2004, 83:140-147. 33. Toure A, Clemente EJ, Ellis P, Mahadevaiah SK, Ojarikre OA, Ball PA, et al.: Identification of novel Y chromosome encoded tran- scripts by testis transcriptome analysis of mice with dele- tions of the Y chromosome long arm. Genome Biol 2005, 6:R102. 34. Regitz-Zagrosek V: Therapeutic implications of the gender- specific aspects of cardiovascular disease. Nat Rev Drug Discov 2006, 5:425-239. 35. Czubryt MP, Espira L, Lamoureux L, Abrenica B: The role of sex in cardiac function and disease. Can J Physiol Pharmacol 2006, 84:93-109. 36. Deschepper CF, Llamas B: Hypertensive cardiac remodeling in males and females: from the bench to the bedside. Hyperten- sion 2007, 49:401-407. 37. Nadeau JH, Singer JB, Matin A, Lander ES: Analysing complex genetic traits with chromosome substitution strains. Nature Genet 2000, 24:221-225. 38. Deschepper CF, Picard S, Thibault G, Touyz R, Rouleau JL: Charac- terization of left ventricular myocardium, isolated cardio- myocytes and blood pressure in WKHA and WKY rats. Am J Physiol 2002, 82:H149-H155. 39. Gerdes AM, Kriseman J, Bishop SP: Morphometric study of car- diac muscle. The problem of tissue shrinkage. Lab Invest 1982, 46:271-274. 40. Rasband WS: 1997 [http://rsb.info.nih.gov/ij/]. ImageJ, U.S. National Institutes of Health, Bethesda, Maryland, USA 41. Bolstad BM, Irizzary RA, Astrand M, Speed TP: A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 2003, 19:185-193. 42. McClintick JN, Edenberg HJ: Effects of filtering by Present call on analysis of microarray experiments. BMC Bioinformatics 2006, 7:49. 43. Cui X, Hwang JT, Qiu J, Blades NJ, Churchill GA: Improved statis- tical tests for differential gene expression by shrinking vari- ance components estimates. Biostatistics 2005, 6:59-75. 44. Benjamini J, Hochberg Y: On the adaptative control of the False Discovery Rate in multiple testing with independent statis- tics. J Educ Behav Stat 2000, 25:60-83. 45. Wu H, Kerr M, Cui X, Churchill GA: MAANOVA: A software package for the analysis of spotted cDNA microarray exper- iments. In The analysis of gene expression data: methods and software Edited by: Parmigiani G, Garett ES, Irizarry RA, Zeger SL. New-York: Springer; 2002. 46. Falcon S, Gentleman R: Using GOstats to test gene lists for GO term association. Bioinformatics 2007, 23:257-258. Publish with Bio Med Central and every scientist can read your work free of charge "BioMed Central will be the most significant development for disseminating the results of biomedical research in our lifetime." Sir Paul Nurse, Cancer Research UK Your research papers will be: available free of charge to the entire biomedical community peer reviewed and published immediately upon acceptance cited in PubMed and archived on PubMed Central yours — you keep the copyright Submit your manuscript here: http://www.biomedcentral.com/info/publishing_adv.asp BioMedcentral Page 11 of 11 (page number not for citation purposes)