Sobani et al. Journal of Medical Case Reports 2011, 5:244 http://www.jmedicalcasereports.com/content/5/1/244 Page 4 of 4 Figure 4 Histopathological examination of the excised tissue. (A) Fibrosarcoma arising in a background of dermatofibrosarcoma protuberans showing proliferation of spindle cells with a prominent storiform pattern and cells exhibiting pleomorphism with increase mitotic activity (H&E, 10 ×). (B) Fibromatosis showing proliferation of bland spindle shaped cells with infiltration into the muscle at the periphery and perivascular lymphocytic infiltrate (H&E, 10 ×). Consent Written informed consent was obtained from the patient for publication of this case report and any accompany- ing images. A copy of the written consent is available for review by the Editor-in-Chief of this journal. Author details 1Medical College, Aga Khan University, Stadium Road, Karachi, Pakistan. 2Division of Otolaryngology, Head & Neck Surgery, Aga Khan University, Stadium Road, Karachi Pakistan. Authors’ contributions ZAS and MJ were primarily involved in compiling patient details, reviewing available literature and drafting the primary manuscript with contributions from the other authors. MJK identified the patient and interpreted the patient data along with contributing to and editing the manuscript. All authors read and approved the final manuscript. Competing interests The authors declare that they have no competing interests. Received: 22 September 2010 Accepted: 27 June 2011 Published: 27 June 2011 References 1. Sze H, Yeung MW: Fibromatosis of the neck causing airway obstruction managed effectively with weekly low-dose methotrexate and vinblastine. Hong Kong Med J 2009, 15:221-223. 2. Sharma A, Ngan BY, Sandor GK, Campisi P, Forte V: Pediatric aggressive fibromatosis of the head and neck: a 20-year retrospective review. J Pediatr Surg 2008, 43:1596-1604. 3. Kruse AL, Luebbers HT, Gratz KW, Obwegeser JA: Aggressive fibromatosis of the head and neck: a new classification based on a literature review over 40 years (1968-2008). Oral Maxillofac Surg 2010, 14(4):227-232. 4. El-Haddad M, El-Sebaie M, Ahmad R, Khalil E, Shahin M, Pant R, Memon M, Al-Hebshi A, Khafaga Y, Al-Shabanah M, Allam A: Treatment of aggressive fibromatosis: the experience of a single institution. Clin Oncol (R Coll Radiol) 2009, 21:775-780. 5. Hoos A, Lewis JJ, Urist MJ, Shaha AR, Hawkins WG, Shah JP, Brennan MF: Desmoid tumors of the head and neck–a clinical study of a rare entity. Head Neck 2000, 22:814-821. 6. Rudiger HA, Ngan SY, Ng M, Powell GJ, Choong PF: Radiation therapy in the treatment of desmoid tumours reduces surgical indications. Eur J Surg Oncol 2010, 36:84-88. 7. Park HC, Pyo HR, Shin KH, Suh CO: Radiation treatment for aggressive fibromatosis: findings from observed patterns of local failure. Oncology 2003, 64:346-352. 8. Constantinidou A, Jones RL, Scurr M, Al-Muderis O, Judson I: Pegylated liposomal doxorubicin, an effective, well-tolerated treatment for refractory aggressive fibromatosis. Eur J Cancer 2009, 45:2930-2934. 9. Nishida Y, Tsukushi S, Shido Y, Wasa J, Ishiguro N, Yamada Y: Successful treatment with meloxicam, a cyclooxygenase-2 inhibitor, of patients with extra-abdominal desmoid tumors: a pilot study. J Clin Oncol 2010, 28:e107-109. 10. Janinis J, Patriki M, Vini L, Aravantinos G, Whelan JS: The pharmacological treatment of aggressive fibromatosis: a systematic review. Ann Oncol 2003, 14:181-190. 11. Chugh R, Chugh R, Wathen JK, Patel SR, Maki RG, Meyers PA, Schuetze SM, Priebat DA, Thomas DG, Jacobson JA, Samuels BL, Benjamin RS, Baker LH, Sarcoma Alliance for Research through Collaboration (SARC): Efficacy of imatinib in aggressive fibromatosis: results of a phase II multicenter Sarcoma Alliance for Research through Collaboration (SARC) trial. Clin Cancer Res 2010, 16(19):4884-9481. 12. Ilaslan H, Schils J, Joyce M, Marks K, Sundaram M: Radiofrequency ablation: another treatment option for local control of desmoid tumors. Skeletal Radiol 2010, 39:169-173. 13. Kujak JL, Liu PT, Johnson GB, Callstrom MR: Early experience with percutaneous cryoablation of extra-abdominal desmoid tumors. Skeletal Radiol 2010, 39:175-182. doi:10.1186/1752-1947-5-244 Cite this article as: Sobani et al.: Successful management of aggressive fibromatosis of the neck using wide surgical excision: a case report. Journal of Medical Case Reports 2011 5:244. Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color ﬁgure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit