BMC Genomics 2007, 8:271 http://www.biomedcentral.com/1471-2164/8/271 34. Keinanen R, Vartiainen N, Koistinaho J: Molecular cloning and characterization of the rat inducible nitric oxide synthase (iNOS) gene. Gene 1999, 234:297-305. 35. Xie QW, Cho HJ, Calaycay J, Mumford RA, Swiderek KM, Lee TD, Ding A, Troso T, Nathan C: Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 1992, 256:225-228. 36. Bailey TL, Elkan C: Fitting a mixture model by expectation maximization to discover motifs in biopolymers. In Proceed- ings of the Second International Conference on Intelligent Systems for Molecular Biology Menlo Park, California, 1994., AAAI Press; 1994:28-36. 37. Bray N, Dubchak I, Pachter L: AVID: A global alignment pro- gram. Genome Res 2003, 13:97-102. 38. Dubchak I, Brudno M, Loots GG, Pachter L, Mayor C, Rubin EM, Frazer KA: Active conservation of noncoding sequences revealed by three-way species comparisons. Genome Res 2000, 10:1304-1306. 39. Mayor C, Brudno M, Schwartz JR, Poliakov A, Rubin EM, Frazer KA, Pachter LS, Dubchak I: VISTA : visualizing global DNA sequence alignments of arbitrary length. Bioinformatics 2000, 16:1046-1047. 40. Ovcharenko I, Loots GG, Hardison RC, Miller W, Stubbs L: zPic- ture: dynamic alignment and visualization tool for analyzing conservation profiles. Genome Res 2004, 14:472-477. 41. Ovcharenko I, Loots GG, Giardine BM, Hou M, Ma J, Hardison RC, Stubbs L, Miller W: Mulan: multiple-sequence local alignment and visualization for studying function and evolution. Genome Res 2005, 15:184-194. 42. Blanchette M, Kent WJ, Riemer C, Elnitski L, Smit AF, Roskin KM, Baertsch R, Rosenbloom K, Clawson H, Green ED, Haussler D, Miller W: Aligning multiple genomic sequences with the threaded blockset aligner. Genome Res 2004, 14:708-715. 43. Repeatmasker [http://www.repeatmasker.org] 44. Tajima F, Nei M: Estimation of evolutionary distance between nucleotide sequences. Mol Biol Evol 1984, 1:269-285. 45. Kumar S, Tamura K, Nei M: MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Brief Bioinform 2004, 5:150-163. 46. Dopazo H, Dopazo J: Genome-scale evidence of the nematode- arthropod clade. Genome Biol 2005, 6:R41. 47. Kel AE, Gossling E, Reuter I, Cheremushkin E, Kel-Margoulis OV, Wingender E: MATCH: A tool for searching transcription fac- tor binding sites in DNA sequences. Nucleic Acids Res 2003, 31:3576-3579. 48. Castrillo A, Traves PG, Martin-Sanz P, Parkinson S, Parker PJ, Bosca L: Potentiation of protein kinase C ζ activity by 15-deoxy- ∆12,14-prostaglandin J2 induces an imbalance between mitogen-activated protein kinases and NF-κB that promotes apoptosis in macrophages. Mol Cell Biol 2003, 23:1196-1208. Publish with Bio Med Central and every scientist can read your work free of charge "BioMed Central will be the most significant development for disseminating the results of biomedical research in our lifetime." Sir Paul Nurse, Cancer Research UK Your research papers will be: available free of charge to the entire biomedical community peer reviewed and published immediately upon acceptance cited in PubMed and archived on PubMed Central yours — you keep the copyright Submit your manuscript here: http://www.biomedcentral.com/info/publishing_adv.asp BioMedcentral Page 10 of 10 (page number not for citation purposes)