BMC Cancer 2009, 9:153 http://www.biomedcentral.com/1471-2407/9/153 Table 6: Patients with moderate to very severe nausea/vomiting or diarrhoea by demographic, treatment and clinical variables. p 0.048 0.001 0.869 0.003 0.705 < 0.001 Diarrhoea 34/284 (12.0) 68/326 (20.9) 54/286 (18.9) 48/324 (14.8) 65/452 (14.4) 37/158 (23.4) 58/313 (18.5) 44/297 (14.8) 30/225 (13.3) 72/385 (18.7) 50/429 (11.7) 50/171 (29.2) p 0.049 < 0.001 0.001 0.004 0.004 < 0.001 0.009 0.088 Multivariate OR# (95% CI@) - 2.6 (1.6–4.0) 0.5 (0.3–0.7) 0.5 (0.3–0.8) - 3.2 (2.0–5.0) 1.9 (1.2–3.1) - p 0.003 0.179 0.009 0.219 0.086 < 0.001 p < 0.001 0.001 0.003 < 0.001 0.006 Variable B symptoms Sex Age Stage Chemotherapy Performance status Number (per cent). Nausea and vomiting* B symptoms present Performance status level 2–4 Male sex PMitCEBO given Diarrhoea** B symptoms present Performance status level 2–4 Age 75 years or older Stage 3 or 4 Category No Yes Female Male < 75 years GE 75 years CHOP PMitCEBO Stage 0–2 Stage 3–4 Level 0–1 Level 2–4 Nausea/vomiting 43/285 (15.1) 69/324 (21.3) 68/285 (23.9) 44/324 (13.6) 84/453 (18.5) 28/156 (17.9) 72/315 (22.9) 40/294 (13.6) 40/227 (17.6) 72/382 (18.8) 60/430 (14.0) 48/169 (28.4) Univariate OR# (95% CI@) 1.5 (1.0–2.3) 2.4 (1.6–3.8) 0.5 (0.3–0.8) 0.5 (0.3–0.8) 1.9 (1.2–3.0) 3.1 (2.0–4.9) 1.8 (1.2–2.9) 1.5 (0.9–2.4) Table 7: Logistic regression for association between moderate to very severe nausea and vomiting and diarrhoea and B symptoms and other potential predictor variables. * The multivariate model is for 599 patients with complete data on all variables included in it. ** The multivariate model is for 600 patients with complete data on all variables included in it. # Odds ratio @ Confidence interval Page 9 of 10 (page number not for citation purposes)