BMC Genomics 2008, 9:298 http://www.biomedcentral.com/1471-2164/9/298 42. Lee MG, Bihain BE, Russell DG, Deckelbaum RJ, Ploeg LH Van der: Characterization of a cDNA encoding a cysteine-rich cell surface protein located in the flagellar pocket of the proto- zoan Trypanosoma brucei. Mol Cell Biol 1990, 10(9):4506-4517. 43. Ziegelbauer K, Multhaup G, Overath P: Molecular characteriza- tion of two invariant surface glycoproteins specific for the bloodstream stage of Trypanosoma brucei. J Biol Chem 1992, 267(15):10797-10803. 44. Nolan DP, Jackson DG, Biggs MJ, Brabazon ED, Pays A, Van Laethem F, Paturiaux-Hanocq F, Elliott JF, Voorheis HP, Pays E: Characteri- zation of a novel alanine-rich protein located in surface microdomains in Trypanosoma brucei. J Biol Chem 2000, 275(6):4072-4080. 45. Mussmann R, Engstler M, Gerrits H, Kieft R, Toaldo CB, Onderwater J, Koerten H, van Luenen HGAM, Borst P: Factors affecting the level and localization of the transferrin receptor in Trypano- soma brucei. J Biol Chem 2004, 279(39):40690-40698. 46. Field MC, Gabernet-Castello C, Dacks JB: Reconstructing the evo- lution of the endocytic system: insights from genomics and molecular cell biology. Adv Exp Med Biol 2007, 607:84-96. 47. Gallop JL, McMahon HT: BAR domains and membrane curva- ture: bringing your curves to the BAR. Biochem Soc Symp 2005:223-231. 48. Machida K, Mayer BJ: The SH2 domain: versatile signaling mod- ule and pharmaceutical target. Biochim Biophys Acta 2005, 1747(1):1-25. 49. Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JY, Zhang J: Bioconductor: open software development for computational biology and bioin- formatics. Genome Biol 2004, 5(10):R80. 50. Smyth GK: Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 2004, 3:Article3. 51. Sykacek P, Furlong RA, Micklem G: A friendly statistics package for microarray analysis. Bioinformatics 2005, 21(21):4069-4070. 52. LaCount DJ, Gruszynski AE, Grandgenett PM, Bangs JD, Donelson JE: Expression and function of the Trypanosoma brucei major surface protease (GP63) genes. J Biol Chem 2003, 278(27):24658-24664. 53. Price HP, Stark M, Smith DF: Trypanosoma brucei ARF1 plays a central role in endocytosis and golgi-lysosome trafficking. Mol Biol Cell 2007, 18(3):864-873. 54. Dhir V, Goulding D, Field MC: TbRAB1 and TbRAB2 mediate trafficking through the early secretory pathway of Trypano- soma brucei. Mol Biochem Parasitol 2004, 137(2):253-265. 55. Sahin A, Lemercier G, Tetaud E, Espiau B, Myler P, Stuart K, Bakalara N, Merlin G: Trypanosomatid flagellum biogenesis: ARL-3A is involved in several species. Exp Parasitol 2004, 108(3–4):126-133. 56. Ackers JP, Dhir V, Field MC: A bioinformatic analysis of the RAB genes of Trypanosoma brucei. Mol Biochem Parasitol 2005, 141(1):89-97. 57. Abeliovich H, Grote E, Novick P, Ferro-Novick S: Tlg2p, a yeast syntaxin homolog that resides on the Golgi and endocytic structures. J Biol Chem 1998, 273(19):11719-11727. 58. Uemura T, Ueda T, Ohniwa RL, Nakano A, Takeyasu K, Sato MH: Systematic analysis of SNARE molecules in Arabidopsis : dis- section of the post-Golgi network in plant cells. Cell Struct Funct 2004, 29(2):49-65. 59. Besteiro S, Coombs GH, Mottram JC: The SNARE protein family of Leishmania major. BMC Genomics 2006, 7:250. 60. Jahn R, Scheller RH: SNAREs – engines for membrane fusion. Nat Rev Mol Cell Biol 2006, 7(9):631-643. 61. Subramaniam C, Veazey P, Redmond S, Hayes-Sinclair J, Chambers E, Carrington M, Gull K, Matthews K, Horn D, Field MC: Chromo- some-wide analysis of gene function by RNA interference in the african trypanosome. Eukaryot Cell 2006, 5(9):1539-1549. 62. Belden WJ, Barlowe C: Distinct roles for the cytoplasmic tail sequences of Emp24p and Erv25p in transport between the endoplasmic reticulum and Golgi complex. J Biol Chem 2001, 276(46):43040-43048. 63. Saint-Pol A, Yelamos B, Amessou M, Mills IG, Dugast M, Tenza D, Schu P, Antony C, McMahon HT, Lamaze C, Johannes L: Clathrin adaptor epsinR is required for retrograde sorting on early endosomal membranes. Dev Cell 2004, 6(4):525-538. 64. Allen CL, Liao D, Chung WL, Field MC: Dileucine signal-depend- ent and AP-1-independent targeting of a lysosomal glycopro- tein in Trypanosoma brucei. Mol Biochem Parasitol 2007, 156(2):175-190. 65. Hall BS, Smith E, Langer W, Jacobs LA, Goulding D, Field MC: Devel- opmental variation in Rab11-dependent trafficking in Trypanosoma brucei. Eukaryot Cell 2005, 4(5):971-980. 66. Helms MJ, Ambit A, Appleton P, Tetley L, Coombs GH, Mottram JC: Bloodstream form Trypanosoma brucei depend upon multi- ple metacaspases associated with RAB11-positive endo- somes. J Cell Sci 2006, 119(Pt 6):1105-1117. 67. Morty RE, Vadasz I, Bulau P, Dive V, Oliveira V, Seeger W, Juliano L: Tropolysin, a new oligopeptidase from African trypano- somes. Biochemistry 2005, 44(44):14658-14669. 68. Caffrey CR, Hansell E, Lucas KD, Brinen LS, Alvarez Hernandez A, Cheng J, Gwaltney SL 2nd, Roush WR, Stierhof YD, Bogyo M, Stever- ding D, McKerrow JH: Active site mapping, biochemical prop- erties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense. Mol Bio- chem Parasitol 2001, 118(1):61-73. 69. Mottram JC, Helms MJ, Coombs GH, Sajid M: Clan CD cysteine peptidases of parasitic protozoa. Trends Parasitol 2003, 19(4):182-187. 70. Anelli T, Alessio M, Mezghrani A, Simmen T, Talamo F, Bachi A, Sitia R: ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family. Embo J 2002, 21(4):835-844. 71. Hsu MP, Muhich ML, Boothroyd JC: A developmentally regulated gene of trypanosomes encodes a homologue of rat protein- disulfide isomerase and phosphoinositol-phospholipase C. Biochemistry 1989, 28(15):6440-6446. 72. Rubotham J, Woods K, Garcia-Salcedo JA, Pays E, Nolan DP: Char- acterization of two protein disulfide isomerases from the endocytic pathway of bloodstream forms of Trypanosoma brucei. J Biol Chem 2005, 280(11):10410-10418. 73. Bringaud F, Peyruchaud S, Baltz D, Giroud C, Simpson L, Baltz T: Molecular characterization of the mitochondrial heat shock protein 60 gene from Trypanosoma brucei. Mol Biochem Parasitol 1995, 74(1):119-123. 74. Tyler KM, Matthews KR, Gull K: The bloodstream differentia- tion-division of Trypanosoma brucei studied using mitochon- drial markers. Proc Biol Sci 1997, 264(1387):1481-1490. 75. Chiang HL, Terlecky SR, Plant CP, Dice JF: A role for a 70-kilodal- ton heat shock protein in lysosomal degradation of intracel- lular proteins. Science 1989, 246(4928):382-385. 76. Gething MJ, Sambrook J: Protein folding in the cell. Nature 1992, 355(6355):33-45. 77. Eisenberg E, Greene LE: Multiple roles of auxilin and hsc70 in clathrin-mediated endocytosis. Traffic 2007, 8(6):640-646. 78. Lee MG, Ploeg LH Van der: Transcription of the heat shock 70 locus in Trypanosoma brucei. Mol Biochem Parasitol 1990, 41(2):221-231. 79. Rodgers MJ, Albanesi JP, Phillips MA: Phosphatidylinositol 4- kinase III-beta is required for golgi maintenance and cytoki- nesis in Trypanosoma brucei. Eukaryot Cell 2007, 6(7):1108-1118. 80. Hart DT, Misset O, Edwards SW, Opperdoes FR: A comparison of the glycosomes (microbodies) isolated from Trypanosoma brucei bloodstream form and cultured procyclic trypomas- tigotes. Mol Biochem Parasitol 1984, 12(1):25-35. 81. Barnard JP, Pedersen PL: Alteration of pyruvate metabolism in African trypanosomes during differentiation from blood- stream into insect forms. Arch Biochem Biophys 1994, 313(1):77-82. 82. Soderling TR: The Ca-calmodulin-dependent protein kinase cascade. Trends Biochem Sci 1999, 24(6):232-236. 83. Postel EH, Weiss VH, Beneken J, Kirtane A: Mutational analysis of NM23-H2/NDP kinase identifies the structural domains crit- ical to recognition of a c-myc regulatory element. Proc Natl Acad Sci USA 1996, 93(14):6892-6897. 84. Nosaka K, Kawahara M, Masuda M, Satomi Y, Nishino H: Associa- tion of nucleoside diphosphate kinase nm23-H2 with human telomeres. Biochem Biophys Res Commun 1998, 243(2):342-348. 85. Chopra P, Koduri H, Singh R, Koul A, Ghildiyal M, Sharma K, Tyagi AK, Singh Y: Nucleoside diphosphate kinase of Mycobacterium Page 26 of 28 (page number not for citation purposes)