Vogt et al. Journal of Medical Case Reports 2011, 5:577 http://www.jmedicalcasereports.com/content/5/1/577 pn A pn B Page 4 of 7 C pn Figure 2 Whole body MRI of our first patient indicated a superficial plexiform neurofibroma (pn) of the left calf (A, B) and an internal plexiform neurofibroma above the right ankle (C). hence, maintenance chemotherapy (CWS-2002-P study) and radiation therapy were initiated. Three weeks before he died, our patient and his relatives opted to terminate the maintenance therapy. Discussion Comparison of the clinical features of our two patients with non-mosaic type-2 NF1 deletions reported here with the manifestations of disease in patients with mole- cularly ascertained type-1 deletions reported by Mautner et al., [5] indicated a considerable overlap of their clini- cal phenotypes. Among the most frequent clinical fea- tures observed in patients with type-1 NF1 deletions were dysmorphic facial features, macrocephaly, hyper- flexibility of the joints, large hands and feet, cognitive impairment/learning disability, and a high tumor load as