Ratuapli et al. Journal of Medical Case Reports 2011, 5:5 http://www.jmedicalcasereports.com/content/5/1/5 Author details 1Department of Medicine, Banner Estrella Medical Center, 9201 W. Thomas Road, Phoenix, AZ 85037, USA. 2Department of Pathology, Banner Estrella Medical Center, 9201 W. Thomas Road, Phoenix, AZ 85037, USA. Authors’ contributions SKR and HZ participated in the conception and literature search. KAM provided and reviewed the pathology slides. SKR, SM, JF and HZ helped to draft the manuscript. All authors read and approved the final manuscript. Competing interests The authors declare that they have no competing interests. Received: 20 February 2010 Accepted: 12 January 2011 Published: 12 January 2011 References 1. Boubenider S, Hiesse C, Goupy C, Kriaa F, Marchand S, Charpentier B: Incidence and consequences of post-transplantation lymphoproliferative disorders. J Nephrol 1997, 10:136-145. 2. Shapiro R, Nalesnik M, McCauley J, Fedorek S, Jordan ML, Scantlebury VP, Jain A, Vivas C, Ellis D, Lombardozzi-Lane S, Randhawa P, Johnston J, Hakala TR, Simmons RL, Fung JJ, Starzl TE: Posttransplant lymphoproliferative disorders in adult and pediatric renal transplant patients receiving tacrolimus-based immunosuppression. Transplantation 1999, 68:1851-1854. 3. Penn I, Hammond W, Brettschneider L, Starzl TE: Malignant lymphomas in transplantation patients. Transplant Proc 1969, 1:106-112. 4. Leblond V, Sutton L, Dorent R, Davi F, Bitker MO, Gabarre J, Charlotte F, Ghoussoub JJ, Fourcade C, Fischer A, et al: Lymphoproliferative disorders after organ transplantation: a report of 24 cases observed in a single center. J Clin Oncol 1995, 13:961-968. 5. Taylor AL, Marcus R, Bradley JA: Post-transplant lymphoproliferative disorders (PTLD) after solid organ transplantation. Crit Rev Oncol Hematol 2005, 56:155-167. 6. Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J, Lister TA, Bloomfield CD: The World Health Organization classification of hematological malignancies report of the Clinical Advisory Committee Meeting, Airlie House, Virginia, November 1997. Mod Pathol 2000, 13:193-207. 7. Tey SK, Marlton PV, Hawley CM, Norris D, Gill DS: Post-transplant hepatosplenic T-cell lymphoma successfully treated with HyperCVAD regimen. Am J Hematol 2008, 83:330-333. 8. Balachandran I, Walker JW Jr, Broman J: Fine needle aspiration cytology of ALK 1(-), CD 30(+) anaplastic large cell lymphoma post renal transplantation: A case report and literature review. Diagn Cytopathol 2010, 38:213-216. 9. Pasquale MA, Weppler D, Smith J, Icardi M, Amador A, Gonzalez M, Kato T, Tzakis A, Ruiz P: Burkitt’s lymphoma variant of post-transplant lymphoproliferative disease (PTLD). Pathol Oncol Res 2002, 8:105-108. 10. Cohen JI: Epstein-Barr virus infection. N Engl J Med 2000, 343:481-492. 11. Hoshida Y, Li T, Dong Z, Tomita Y, Yamauchi A, Hanai J, Aozasa K: Lymphoproliferative disorders in renal transplant patients in Japan. Int J Cancer 2001, 91:869-875. 12. Magro CM, Weinerman DJ, Porcu PL, Morrison CD: Post-transplant EBV- negative anaplastic large-cell lymphoma with dual rearrangement: a propos of two cases and review of the literature. J Cutan Pathol 2007, 34:1-8. 13. Gottschalk S, Rooney CM, Heslop HE: Post-transplant lymphoproliferative disorders. Annu Rev Med 2005, 56:29-44. 14. Orjuela M, Gross TF, Cheung YK, Alobeid B, Morris E, Cairo MS: A pilot study of chemoimmunotherapy (cyclophosphamide, prednisone, and rituximab) in patients with post-transplant lymphoproliferative disorder following solid organ transplantation. Clin Cancer Res 2003, 9:3945S-3952S. 15. Taylor AL, Bowles KM, Callaghan CJ, Wimperis JZ, Grant JW, Marcus RE, Bradley JA: Anthracycline-based chemotherapy as first-line treatment in adults with malignant posttransplant lymphoproliferative disorder after solid organ transplantation. Transplantation 2006, 82:375-381. doi:10.1186/1752-1947-5-5 Cite this article as: Ratuapli et al.: Epstein Barr Virus-positive large T-cell lymphoma presenting as acute appendicitis 17 years after cadaveric renal transplant: a case report. Journal of Medical Case Reports 2011 5:5. Page 8 of 8 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color ﬁgure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit