Morgan et al. BMC Cancer 2010, 10:89 http://www.biomedcentral.com/1471-2407/10/89 guidelines for the welfare of animals in experimental neoplasia (second edition). Br J Cancer 1998, 77:1-10. 13. Jiang T, Olson ES, Nguyen QT, Roy M, Jennings PA, Tsien RY: Tumour imaging by means of proteolytic activation of cell-penetrating peptides. Proc Natl Acad Sci USA 2004, 101:17867-72. 14. Lazebnik YA, Kaufmann SH, Desnoyers S, Poirier GG, Earnshaw WC: Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 1994, 371:346-7. 15. Takahashi Y, Hamada J, Murakawa K, Takada M, Tada M, Nogami I, Hayashi N, Nakamori S, Monden M, Miyamoto M, Katoh H, Moriuchi T: Expression profiles of 39 HOX genes in normal human adult organs and anaplastic thyroid cancer cell lines by quantitative real-time RT-PCR system. Exp Cell Res 2004, 293:144-53. 16. Redline RW, Hudock P, MacFee M, Patterson P: Expression of AbdB-type homeobox genes in human tumors. Lab Invest 1994, 71:663-70. 17. Cillo C: HOX genes in human cancers. Invasion Metastasis 1994, 14:38-49. 18. Cantile M, Cindolo L, Napodano G, Altieri V, Cillo C: Hyperexpression of locus C genes in the HOX network is strongly associated in vivo with human bladder transitional cell carcinomas. Oncogene 2003, 22(41):6462-8. 19. Miller GJ, Miller HL, van Bokhoven A, Lambert JR, Werahera PN, Schirripa O, Lucia MS, Nordeen SK: Aberrant HOXC expression accompanies the malignant phenotype in human prostate. Cancer Res 2003, 63:5879-88. 20. Waltregny D, Alami Y, Clausse N, de Leval J, Castronovo V: Overexpression of the homeobox gene HOXC8 in human prostate cancer correlates with loss of tumor differentiation. Prostate 2002, 50:162-9. 21. Abe M, Hamada J, Takahashi Y, Tada M, Miyamoto M, Morikawa T, Kondo S, Moriuchi T: Disordered expression of HOX genes in human non-small cell lung cancer. Oncol Rep 2006, 15:797-802. 22. Ota T, Klausen C, Salamanca MC, Woo HL, Leung PC, Auersperg N: Expression and function of HOXA genes in normal and neoplastic ovarian epithelial cells. Differentiation 2009, 77(2):162-71. 23. Wu Q, Lothe RA, Ahlquist T, Silins I, Tropé CG, Micci F, Nesland JM, Suo Z, Lind GE: DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets. Mol Cancer 2007, 10(6):45. 24. Su X, Drabkin H, Clappier E, Morgado E, Busson M, Romana S, Soulier J, Berger R, Bernard OA, Lavau C: Transforming potential of the T-cell acute lymphoblastic leukemia-associated homeobox genes HOXA13, TLX1, and TLX3. Genes Chromosomes Cancer 2006, 45(9):846-55. 25. Nagel S, Burek C, Venturini L, Scherr M, Quentmeier H, Meyer C, Rosenwald A, Drexler HG, MacLeod RA: Comprehensive analysis of homeobox genes in Hodgkin lymphoma cell lines identifies dysregulated expression of HOXB9 mediated via ERK5 signaling and BMI1. Blood 2007, 109(7):3015-23. 26. Li H, Huang CJ, Choo KB: Expression of homeobox genes in cervical cancer. Gynecol Oncol 2002, 84(2):216-21. 27. Li W, Zhang X, Olumi AF: MG-132 sensitizes TRAIL-resistant prostate cancer cells by activating c-Fos/c-Jun heterodimers and repressing c-FLIP(L). Cancer Res 2007, 67:2247-55. 28. Zhang X, Zhang L, Yang H, Huang X, Otu H, Libermann TA, Dewolf WC, Khosravi-Far R, Olumi AF: c-Fos as a proapoptotic agent in TRAIL-induced apoptosis in prostate cancer cells. Cancer Res 2007, 67:9425-34. 29. Sugiyama T, Konishi I: Emerging drugs for ovarian cancer. Expert Opin Emerg Drugs 2008, 13:523-36. Pre-publication history The pre-publication history for this paper can be accessed here:http://www. biomedcentral.com/1471-2407/10/89/prepub doi:10.1186/1471-2407-10-89 Cite this article as: Morgan et al.: Targeting HOX and PBX transcription factors in ovarian cancer. BMC Cancer 2010 10:89. Page 9 of 9 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color ﬁgure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit