Albergaria et al. BMC Cancer 2011, 11:299 http://www.biomedcentral.com/1471-2407/11/299 Page 5 of 10 Figure 1 Long term overall and disease-free survival in breast cancer subtypes according with Nottingham Prognostic Index. Kaplan- Meier plots for a general series comprising all subtypes of invasive breast tumours (A and B). As expected, NPI clearly separate different groups with distinct outcomes, showing that patients with NPI > 5.4 presented a much worse prognosis compared with patients with moderate and good prognosis; (C and D) Kaplan-Meier plots for luminal subtype breast carcinomas. NPI is similarly able to stratify breast cancer patient into different survival outcomes; (E and F) Kaplan-Meier plots for HER2 subtype breast carcinomas. None of the patients encompassing this subgroup presented a NPI < 3.4. Although lacking statistical association, NPI is still able to discriminate between moderate and poor prognosis patients; (G and H) Kaplan-Meier survival plots for TNBC subtype. Most of the patients within this subtype fell into the group with NPI > 5.4. Even though, NPI had the statistically significant power to stratify patients with distinct outcomes.