Apc Adhfe1 Cluster 4 Ctla4 Cxcl7 Cluster 5 Mrps5 Sf4 Cluster 6 Asb2 Cluster 7 Dnahc2 Ccdc89 At 4 h: Cluster 1 Cnn3 Cdh10 Itga6 Cluster 2 Sycp1 Cluster 3 Atad1 St8sia6 Prkce Cluster 4 Shprh Zfp39 Cluster 5 Cep110 At 12 h: Cluster 1 Cdh1 Gja1 Cluster 2 Rab17 adenomatosis polyposis coli alcohol dehydrogenase, iron containing, 1 Immune response cytotoxic T-lymphocyte-associated protein 4 chemokine (C-X-C motif) ligand 7 RNA binding protein, Translation factor mitochondrial ribosomal protein S5 splicing factor 4 DNA binding protein, Transcription factor ankyrin repeat and SOCS box-containing protein 2 Miscellaneous dynein, axonemal, heavy chain 2 coiled-coil domain containing 89 Adhesion molecules, Cytoskeleton, Cell movement calponin 3, acidic cadherin 10 Integrin alpha 6 Cell cycle, DNA repair, Apoptosis synaptonemal complex protein 1 Enzyme, Kinase ATPase family, AAA domain containing 1 ST8 alpha-N-acetyl-neuraminide alpha-2,8- sialyltransferase 6 Protein kinase C, epsilon DNA binding protein, Transcription factor SNF2 histone linker PHD RING helicase zinc finger protein 39 Miscellaneous centrosomal protein 110 Adhesion molecules, cytoskeleton; cell movement Cadherin 1 gap junction membrane channel protein alpha 1 Signal transmission, Transporter RAB17, member RAS oncogene family Yin et al. BMC Genomics 2010, 11:612 http://www.biomedcentral.com/1471-2164/11/612 Page 7 of 18 Table 2: Up-regulation of genes in iBMDCs treated with [BF/S+L/Ep] for (A) 4 h or (B) 12 h compared to DMSO alone (Continued) aExpression ratio is defined as relative difference in expression with (+) compared to without (-) treatment with [BF/S+L/Ep] plant extract; (-) is DMSO vehicle control. Table 3 Down-regulation of genes in iBMDCs treated with [BF/S+L/Ep] for (A) 4 h or (B) 12 h compared to DMSO alone Gene Title Accession Number Expression Ratioa (+)/(-) NM_007462 NM_175236 NM_009843 NM_023785 NM_029963 NM_027481 NM_023049 O08826 Q9DA73 NM_028044 Q3UUB3 NM_008397 NM_011516 NM_026487 NM_145838 NM_011104 NM_172937 NM_011758 XM_981952 NM_009864 NM_010288 NM_008998 2.15 2.04 11.16 2.77 2.20 2.45 2.75 3.11 2.01 0.13 0.27 0.50 0.25 0.48 0.45 0.47 0.27 0.31 0.46 0.30 0.48 0.42