BMC Genomics 2009, 10:442 http://www.biomedcentral.com/1471-2164/10/442 33. Hunsucker SA, Mitchell BS, Spychala J: The 5'-nucleotidases as regulators of nucleotide and drug metabolism. Pharmacol Ther 2005, 107:1-30. 34. Bianchi V, Spychala J: Mammalian 5'-nucleotidases. J Biol Chem 2003, 278:46195-46198. 35. MacInnes AW, Amsterdam A, Whittaker CA, Hopkins N, Lees JA: Loss of p53 synthesis in zebrafish tumors with ribosomal pro- tein gene mutations. Proc Natl Acad Sci USA 2008, 105:10408-10413. 36. Aruga J, Minowa O, Yaginuma H, Kuno J, Nagai T, Noda T, Mikoshiba K: Mouse Zic1 is involved in cerebellar development. J Neuro- sci 1998, 18:284-293. 37. Aruga J, Mizugishi K, Koseki H, Imai K, Balling R, Noda T, Mikoshiba K: Zic1 regulates the patterning of vertebral arches in coop- eration with Gli3. Mech Dev 1999, 89:141-150. 38. Boria I, Quarello P, Avondo F, Garelli E, Aspesi A, Carando A, Cam- pagnoli MF, Dianzani I, Ramenghi U: A new database for ribos- omal protein genes which are mutated in Diamond-Blackfan Anemia. Hum Mutat 2008, 29:E263-270. 39. Diamond-Blackfan anemia Leiden Open Variation Database [http://www.dbagenes.unito.it/home.php] 40. The R Project for Statistical Computing [http://www.r- project.org/] 41. BioConductor open source software for bioinformatics [http://www.bioconductor.org/] 42. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, Speed TP: ummaries of Affymetrix GeneChip probe level data. Nucleic Acids Res 2003, 31:Se15. 43. McClintick JN, Edenberg HJ: Effects of filtering by Present call on analysis of microarray experiments. BMC Bioinformatics 2006, 7:49. 44. Saeed AI, Sharov V, White J, Li J, Liang W, Bhagabati N, Braisted J, Klapa M, Currier T, Thiagarajan M, Sturn A, Snuffin M, Rezantsev A, Popov D, Ryltsov A, Kostukovich E, Borisovsky I, Liu Z, Vinsavich A, Trush V, Quackenbush J: TM4: a free, open-source system for microarray data management and analysis. Biotechniques 2003, 34(2):374-378. 45. Tusher VG, Tibshirani R, Chu G: Significance analysis of micro- arrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 2001, 98:5116-5121. 46. Chu G, Narasimhan B, Tibshirani R, Tusher V: SAM "Significance Analysis of Microarrays" Users Guide and Technical Docu- ment. [http://www-stat.stanford.edu/~tibs/SAM/]. Publish with Bio Med Central and every scientist can read your work free of charge "BioMed Central will be the most significant development for disseminating the results of biomedical research in our lifetime." Sir Paul Nurse, Cancer Research UK Your research papers will be: available free of charge to the entire biomedical community peer reviewed and published immediately upon acceptance cited in PubMed and archived on PubMed Central yours — you keep the copyright Submit your manuscript here: http://www.biomedcentral.com/info/publishing_adv.asp BioMedcentral Page 12 of 12 (page number not for citation purposes)