BMC Genomics 2009, 10:435 http://www.biomedcentral.com/1471-2164/10/435 cFSocigadtuitnergergp6elnoets sfohro:w(ain)ghKuma/aKns/droatgiococmompaprairsoisnosn,s(b)ethwumeeann/TmPoAuseqcuoemncpeasriasondnstheir respective orthologous parental protein Scatter plots showing Ka/Ks ratio comparisons between TPA sequences and their respective orthologous parental protein coding genes for: (a) human/dog comparisons, (b) human/mouse comparisons. Ka/Ks values for TPAs, that are significantly less than values for neutral selection determined by simulation, are indicated as circle symbols, else the Ka/Ks values are indicated with square symbols. Those TPAs that have a disrupted protein domain of known three-dimen- sional structure are indicated with unfilled symbols, those without such a domain are indicated with filled symbols. Page 9 of 14 (page number not for citation purposes)