Ross et al. Journal of Medical Case Reports 2011, 5:383 http://www.jmedicalcasereports.com/content/5/1/383 accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal. Author details 1St Mary’s Hospital, Imperial Healthcare NHS Trust, Praed Street, London W2 1UL, UK. 2Barking, Haveridge and Redbridge University Hospitals NHS Trust, Rom Valley Way, Romford, Essex, RM7 0AG, UK. 3Northwick Park Hospital, Northwest London Hospital NHS Trust, Watford Road, Harrow, HA1 3UJ, UK. 4Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK. Authors’ contributions CR and SS wrote the manuscript. SS and OL were involved in the initial management of our patient. IL, MS, AH and IJ were involved in the subsequent management of our patient. All authors contributed to and critically reviewed the final manuscript. Competing interests The authors declare that they have no competing interests. Received: 29 November 2010 Accepted: 16 August 2011 Published: 16 August 2011 References 1. Folpe AL: Neoplasms with perivascular epithelioid cell differentiation (PEComas). In Pathology and Genetics of Tumours of Soft Tissue and Bone. Series: WHO Classification of Tumours. Edited by: Fletcher CDM, Unni KK, Epstein J, Mertens F. Lyon, France: IARC Press; 2002:221-222. 2. Wagner AJ, Malinowska-Kolodziej I, Morgan JA, Qin W, Fletcher CD, Vena N, Ligon AH, Antonescu CR, Ramaiya NH, Demetri GD, Kwiatkowski DJ, Maki RG: Clinical activity of mTOR inhibition with sirolimus in malignant perivascular epithelioid cell tumors: targeting the pathogenic activation of mTORC1 in Tumors. J Clin Oncol 2010, 28:835-840. 3. Folpe AL, Mentzel T, Lehr HA, Fisher C, Balzer BL, Weiss SW: Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature. Am J Surg Pathol 2005, 29:1558-1575. 4. Michal M, Zamecnik M: Hyalinized uterine mesenchymal neoplasms with HMB-45-positive epithelioid cells: epithelioid leiomyomas or angiomyolipomas? Report of four cases. Int J Surg Pathol 2000, 8:323-332. 5. Vang R, Kempson RL: Perivascular epithelioid cell tumor (’PEComa’) of the uterus: a subset of HMB-45-positive epithelioid mesenchymal neoplasms with an uncertain relationship to pure smooth muscle tumors. Am J Surg Pathol 2002, 26:1-13. 6. Pan CC, Yu IT, Yang AH, Chiang H: Clear cell myomelanocytic tumor of the urinary bladder. Am J Surg Pathol 2003, 27:689-692. 7. Fink D, Marsden DE, Edwards L, Camaris C, Hacker NF: Malignant perivascular epithelioid cell tumor (PEComa) arising in the broad ligament. Int J Gynecol Cancer 2004, 14:1036-1039. 8. Pea M, Bonetti F, Zamboni G, Martignoni G, Fiore-Donati L, Doglioni C: Clear cell tumour and angiomyolipoma. Am J Surg Pathol 1991, 15:199-201. 9. Fukunaga M: Perivascular epithelioid cell tumor of the uterus: report of four cases. Int J Gynecol Pathol 2005, 24:341-346. 10. Bonis RT, Domínguez TP, Calatayud FR, Jiménez EC, Piris MA, López- Lucendo NJ: Pelvic PEcoma of the broad ligament with lymph node metastasis: case report and bibliographic review. Arch Esp Urol 2008, 61:744-748. 11. Kim HJ, Lim SJ, Choi H, Park K: Malignant clear-cell myomelanocytic tumor of broad ligament–a case report. Virchows Archiv 2006, 6:867-870. 12. Ryś J, Karolewski K, Pudełek J, Kruczak A, Wasilewska A, Vogelgesang M, Kojs Z: Perivascular epithelioid tumour (PEComa) of the falciform/broad ligament. Pol j Pathol 2008, 59:211-215. 13. Martignoni G, Pea M, Reghellin D, Zamboni G, Bonetti F: PEComas: the past, the present and the future. Virchows Arch 2008, 452:119-132. 14. Webster AC, Lee VW, Chapman JR, Craig JC: Target of rapamycin inhibitors (sirolimus and everolimus) for primary immunosuppression of kidney transplant recipients: a systematic review and meta-analysis of randomized trials. Transplantation 2006, 81:1234-1248. Page 6 of 6 15. Italiano A, Delcambre C, Hostein I, Cazeau AL, Marty M, Avril A, Coindre JM, Bui B: Treatment with the mTOR inhibitor temsirolimus in patients with malignant PEComa. Ann Oncol 2010, 21:1135-1137. 16. Subbiah V, Trent JC, Kurzrock R: Resistance to mammalian target of rapamycin inhibitor therapy in perivascular epithelioid cell tumors. J Clin Oncol 2010, 28:415. doi:10.1186/1752-1947-5-383 Cite this article as: Ross et al.: A patient presenting with a perivascular epithelioid cell tumor in the broad ligament: a case report. Journal of Medical Case Reports 2011 5:383. Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color ﬁgure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit