BMC Cancer 2006, 6:175 http://www.biomedcentral.com/1471-2407/6/175 The excellent technical assistance of Lourdes Pedersen, Anne-Karin Jensen and Birgitte Korsholm is gratefully acknowledged. References 1. Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Lep- pert M, Nakamura Y, White R, Smits AM, Bos JL: Genetic altera- tions during colorectal-tumor development. N Engl J Med 1988, 319(9):525-532. 2. Potter JD: Colorectal cancer: molecules and populations. J Natl Cancer Inst 1999, 91(11):916-932. 3. De Jong MM, Nolte IM, Te Meerman GJ, Van Der Graaf WT, De Vries EG, Sijmons RH, Hofstra RM, Kleibeuker JH: Low-penetrance Genes and Their Involvement in Colorectal Cancer Suscep- tibility. Cancer Epidemiol Biomarkers Prev 2002, 11(11):1332-1352. 4. Johnson GC, Esposito L, Barratt BJ, Smith AN, Heward J, Di Genova G, Ueda H, Cordell HJ, Eaves IA, Dudbridge F, Twells RC, Payne F, Hughes W, Nutland S, Stevens H, Carr P, Tuomilehto-Wolf E, Tuomilehto J, Gough SC, Clayton DG, Todd JA: Haplotype tagging for the identification of common disease genes. Nat Genet 2001, 29(2):233-237. 5. Yin J, Rockenbauer E, Hedayati M, Jacobsen NR, Vogel U, Grossman L, Bolund L, Nexo BA: Multiple single nucleotide polymor- phisms on human chromosome 19q13.2-3 associate with risk of Basal cell carcinoma. Cancer Epidemiol Biomarkers Prev 2002, 11(11):1449-1453. 6. Nexo BA, Vogel U, Olsen A, Ketelsen T, Bukowy Z, Thomsen BL, Wallin H, Overvad K, Tjonneland A: A specific haplotype of single nucleotide polymorphisms on chromosome 19q13.2-3 encompassing the gene RAI is indicative of post-menopausal breast cancer before age 55. Carcinogenesis 2003, 24(5):899-904. 7. Vogel U, Laros I, Jacobsen NR, Thomsen BL, Bak H, Olsen A, Bukowy Z, Wallin H, Overvad K, Tjonneland A, Nexo BA, Raaschou-Nielsen O: Two regions in chromosome 19q13.2-3 are associated with risk of lung cancer. Mutat Res 2004, 546(1–2):65-74. 8. Laska MJ, Nexo BA, Vistisen K, Poulsen HE, Loft S, Vogel U: Poly- morphisms in RAI and in genes of nucleotide and base exci- sion repair are not associated with risk of testicular cancer. Cancer Lett 2005, 225(2):245-251. 9. van Duin M, de Wit J, Odijk H, Westerveld A, Yasui A, Koken HM, Hoeijmakers JH, Bootsma D: Molecular characterization of the human excision repair gene ERCC-1: cDNA cloning and amino acid homology with the yeast DNA repair gene RAD10. Cell 1986, 44(6):913-923. 10. Wood RD: Nucleotide excision repair in mammalian cells. J Biol Chem 1997, 272(38):23465-23468. 11. Whitehead CM, Winkfein RJ, Fritzler MJ, Rattner JB: ASE-1: a novel protein of the fibrillar centres of the nucleolus and nucleolus organizer region of mitotic chromosomes. Chromosoma 1997, 106(8):493-502. 12. Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Mura- matsu M: Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription. Mol Cell Biol 2004, 24(14):6338-6349. 13. Yang JP, Hori M, Sanda T, Okamoto T: Identification of a novel inhibitor of nuclear factor-kappaB, RelA-associated inhibi- tor. J Biol Chem 1999, 274(22):15662-15670. 14. Gondal G, Grotmol T, Hofstad B, Bretthauer M, Eide TJ, Hoff G: The Norwegian Colorectal Cancer Prevention (NORCCAP) screening study: baseline findings and implementations for clinical work-up in age groups 50–64 years. Scand J Gastroenterol 2003, 38(6):635-642. 15. ClinicalTrials.gov [http://www.clinicaltrials.gov] 16. Miller SA, Dykes DD, Polesky HF: A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988, 16(3):1215. 17. Hansen R, Saebo M, Skjelbred CF, Nexo BA, Hagen PC, Bock G, Bow- itz Lothe IM, Johnson E, Aase S, Hansteen IL, Vogel U, Kure EH: GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer. Cancer Lett 2005, 229(1):85-91. 18. Rockenbauer E, Bendixen MH, Bukowy Z, Yin J, Jacobsen NR, Heda- yati M, Vogel U, Grossman L, Bolund L, Nexo BA: Association of chromosome 19q13.2-3 haplotypes with basal cell carci- noma: tentative delineation of an involved region using data for single nucleotide polymorphisms in two cohorts. Carcino- genesis 2002, 23(7):1149-1153. 19. Vogel U, Hedayati M, Dybdahl M, Grossman L, Nexo BA: Polymor- phisms of the DNA repair gene XPD: correlations with risk of basal cell carcinoma revisited. Carcinogenesis 2001, 22(6):899-904. 20. Vogel U, Olsen A, Wallin H, Overvad K, Tjonneland A, Nexo BA: Effect of polymorphisms in XPD, RAI, ASE-1 and ERCC1 on the risk of basal cell carcinoma among Caucasians after age 50. Cancer Detect Prev 2005, 29(3):209-214. 21. Vogel U, Sorensen M, Hansen R, Tjonneland A, Overvad K, Wallin H, Nexo B, Raaschou-Nielsen O: Gene-environment interactions between smoking and a haplotype of RAI, ASE-1 and ERCC1 polymorphisms among women in relation to risk of lung can- cer in a population-based study. Cancer Lett 2006 in press. 22. Bergamaschi D, Samuels Y, O'Neil NJ, Trigiante G, Crook T, Hsieh JK, O'Connor DJ, Zhong S, Campargue I, Tomlinson ML, Kuwabara PE, Lu X: iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. Nat Genet 2003, 33(2):162-167. 23. Zhang X, Wang M, Zhou C, Chen S, Wang J: The expression of iASPP in acute leukemias. Leuk Res 2005, 29(2):179-183. 24. Vogel U, Nexo BA, Tjonneland A, Wallin H, Hertel O, Raaschou- Nielsen O: ERCC1, XPD and RAI mRNA levels in lym- phocytes are not associated with lung cancer risk in a pro- spective study of Danes. Mutat Res 2006, 593(1–2):88-96. 25. Yamazaki T, Hamano Y, Tashiro H, Itoh K, Nakano H, Miyatake S, Saito T: CAST, a novel CD3epsilon-binding protein transduc- ing activation signal for interleukin-2 production in T cells. J Biol Chem 1999, 274(26):18173-18180. Pre-publication history The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2407/6/175/pre pub Publish with Bio Med Central and every scientist can read your work free of charge "BioMed Central will be the most significant development for disseminating the results of biomedical research in our lifetime." 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