BMC Cancer 2006, 6:30 http://www.biomedcentral.com/1471-2407/6/30 References 1. Stuschke M, Thames H: Hyperfractionation: where do we stand? Radiother Oncol 1998, 46:131-33. 2. Adelstein DJ, Sharan VM, Earle AS, Shah AC, Vlastou C, Haria CD, Damm C, Carter SG, Hines JD: Concomitant versus sequential combined technique therapy for squamous cell head and neck cancer. Cancer 1990, 65:1685-91. 3. Wendt TG, Grabenbauer GG, Rodel CM, Thiel HJ, Aydin H, Rohloff R, Wustrow TP, Iro H, Popella C, Schalhorn A: Concomitant radi- ochemotherapy versus radiotherapy alone in advanced head and neck cancer: a randomized multicenter study. J Clin Oncol 1998, 16:1318-24. 4. Budach V, Stuschke M, Budach W, Baumann M, Geismar D, Graben- bauer G, Lammert I, Jahnke K, Stueben G, Herrmann T, Bamberg M, Wust P, Hinkelbein W, Wernecke KD: Hyperfractionated accel- erated chemoradiation with concurrent fluorouracil-mito- mycin is more effective than dose-escalated hyperfractionated accelerated radiation therapy alone in locally advanced head and neck cancer: final results of the Radiotherapy Cooperative Clinical Trials Group of the Ger- man Cancer Society 95-06 Prospective Randomized Trial. J Clin Oncol 2005, 23:1125-1135. 5. Pignon JP, Bourhis J, Domenge C, Designe L: Chemotherapy added to locoregional treatment for head and neck squa- mous-cell carcinoma: three meta-analyses of updated indi- vidual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer. Lancet 2000, 355:949-55. 6. Spiessl B, Beahrs OH, Hermanek P, Hutter RV, Scheibe O, Sobin LH, Wagner G: TNM atlas. In Illustrated guide to the TNM/pTNM classifi- cation of malignant tumors (ed 3, 2nd rev) Berlin, Germany, Springer- Verlag; 1992. 7. Cox JD, Stetz J, Pajak TF: Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organ- ization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 1995, 31:1341-46. 8. Rubin P, Constine LS, Fajardo LF, Phillips TL, Wasserman TH: Late Effects Working Group. Overview. Late Effects of Normal Tissues (LENT) scoring system. Int J Radiat Oncol Biol Phys 1995, 30:1041-42. 9. Miller AB, Hoogstraten B, Staquet M, Winkler A: Reporting results of cancer treatment. Cancer 1981, 47:207-14. 10. Dinges S, Budach V, Stuschke M, Budach W, Boehmer D, Schrader M, Jahnke K, Sack H: Chemo-radiotherapy for locally advanced head and neck cancer – long-term results of a phase II trial. Eur J Cancer 1997, 33:1152-55. 11. Kaplan EL, Meier P: Nonparametric estimation from incom- plete observations. J Am Stat Assoc 1958, 53:457-81. 12. Wibault P, Bensmaine MA, de Forni M, Armand JP, Tellez Bernal E, Guillot T, Recondo G, Domenge C, Janot F, Borel C, Luboinski B, Eschwege F, Cvitkovic E: Intensive concomitant chemoradio- therapy in locally advanced unresectable squamous cell car- cinoma of the head and neck: a phase II study of radiotherapy with cisplatin and 7-week continuous infusional fluorouracil. J Clin Oncol 1996, 14:1192-200. 13. Paccagnella A, Orlando A, Marchiori C, Zorat PL, Cavaniglia G, Sileni VC, Jirillo A, Tomio L, Fila G, Fede A, et al.: Phase III trial of initial chemotherapy in stage III or IV head and neck cancers: a study by the Gruppo di Studio sui Tumori della Testa e del Collo. J Natl Cancer Inst 1994, 86:265-72. 14. Brizel DM: Radiotherapy and concurrent chemotherapy for the treatment of locally advanced head and neck squamous cell carcinoma. Sem Radiat Oncol 1998, 8:237-46. 15. Merlano M, Benasso M, Corvo R, Rosso R, Vitale V, Blengio F, Num- ico G, Margarino G, Bonelli L, Santi L: Five-year update of a rand- omized trial of alternating radiotherapy and chemotherapy compared with radiotherapy alone in treatment of unresect- able squamous cell carcinoma of the head and neck. J Natl Cancer Inst 1996, 88:583-89. 16. Fu KK, Phillips TL, Silverberg IJ, Jacobs C, Goffinet DR, Chun C, Fried- man MA, Kohler M, McWhirter K, Carter SK: Combined radio- therapy and chemotherapy with bleomycin and methotrexate for advanced inoperable head and neck can- cer: Update of a Northern California Oncology Group rand- omized trial. J Clin Oncol 1987, 5:1410-18. 17. Slootweg PJ, Hordijk GJ, Koole R: Autopsy findings in patients with head and neck squamous cell cancer and their thera- peutic relevance. Eur J Cancer B Oral Oncol 1996, 32B:413-15. 18. Adelstein DJ, Tan EH, Lavertu P: Treatment of head and neck cancer: the role of chemotherapy. Crit Rev Oncol Hematol 1996, 24:97-116. 19. Brizel DM, Albers ME, Fisher SR, Scher RL, Richtsmeier WJ, Hars V, George SL, Huang AT, Prosnitz LR: Hyperfractionated irradia- tion with or without concurrent chemotherapy for locally advanced head and neck cancer. N Engl J Med 1998, 338:1798-804. 20. Staar S, Rudat V, Stuetzer H, Dietz A, Volling P, Schroeder M, Flentje M, Eckel HE, Mueller RP: Intensified hyperfractionated acceler- ated radiotherapy limits the additional benefit of simulane- ous chemotherapy – results of a multicentric randomized German trial in advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys 2001, 50(5):1161-71. 21. Taylor SG 4th, Murthy AK, Vannetzel JM, Colin P, Dray M, Caldarelli DD, Shott S, Vokes E, Showel JL, Hutchinson JC: Randomized com- parison of neoadjuvant cisplatin and fluorouracil infusion fol- lowed by radiation versus concomitant treatment in advanced head and neck cancer. J Clin Oncol 1994, 12:385-95. Pre-publication history The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2407/6/30/prepub Publish with Bio Med Central and every scientist can read your work free of charge "BioMed Central will be the most significant development for disseminating the results of biomedical research in our lifetime." Sir Paul Nurse, Cancer Research UK Your research papers will be: available free of charge to the entire biomedical community peer reviewed and published immediately upon acceptance cited in PubMed and archived on PubMed Central yours — you keep the copyright Submit your manuscript here: http://www.biomedcentral.com/info/publishing_adv.asp BioMedcentral Page 9 of 9 (page number not for citation purposes)