Martin et al. BMC Genomics 2010, 11:418 http://www.biomedcentral.com/1471-2164/11/418 Page 4 of 20 Table 1 Genes altered significantly in liver by starvation TRAITS IDENTIFIER1 ACC2 AFL3 ASL4 PSL5 FC A FC B FC C group7 Blood and serum proteins liv_stb_J4D11_sti_tra_sub_0p_11S liv_ali_02H02_abe_tra_sub_0p_11C tes_opk_14E17_osl_sgp_std_5p_11S CK899203 int_oss_T5O22_osl_sal_std_5p_11C CK885870 -2.15 -2.74 BCd AM397499 AM402609 AJ425729 EG648831 CK896319 CK895001 CK879377 AM402930 CK885697 No Acc BM413811 AM042306 29.57 12.79 3.63 spl_sts_19B11_sti_sal_std_5p_12S mus_snm_10F04_osl_tra_nrc_5p_11C swi_rpk_74B22_osl_sgp_std_5p_11C Energy metabolism swi_rpk_74M05_osl_sgp_std_5p_11S gil_oss_52N23_osl_sal_std_5p_11C liv_ali_06G02_abe_tra_sub_0p_11S int_oss_T5A05_osl_sal_std_5p_11C pit_cpi_C1C04_car_tra_sub_0p_11C tes_tsr_02H11_gal_sal_std_5p_11C Stress response kid_aki_05A08_abe_tra_sub_0p_11C hrt_opk_04E05_osl_sgp_std_5p_11C gil_oss_GHB16_osl_sal_std_5p_11C CK883188 15.54 7.86 CN181053 int_oss_T5B18_osl_sal_std_5p_11C CK885962 2.31 liv_opk_12F09_osl_sgp_std_5p_11C int_oss_T4K02_osl_sal_std_5p_11C gil_rpk_76A21_osl_sgp_std_5p_11C CK888938 CK884637 CK878328 hrt_opk_08M01_osl_sgp_std_5p_11C bra_snb_06F02_osl_tra_nrc_5p_11C CK899423 -2.39 EG647964 Immune related swi_rpk_74F07_osl_sgp_std_5p_11C liv_ali_02G01_abe_tra_sub_0p_11C liv_lrr_01C04_gal_sal_std_5p_11C eye_opk_20I02_osl_sgp_std_5p_11S liv_dis_D1E12_abe_tra_sub_0p_11N liv_dis_D4H02_abe_tra_sub_0p_11N liv_dis_D4B06_abe_tra_sub_0p_11N liv_dis_D1G04_abe_tra_sub_0p_11N kid_aki_05H02_abe_tra_sub_0p_11C tes_tsa_01C01_gal_sal_std_5p_11C liv_lrr_01C06_gal_sal_std_5p_11C CK896920 AM402595 No Acc CO471610 7.56 2.97 AM049479 16.18 6.74 AM049741 14.11 7.30 AM049686 AM049505 2.65 AM042371 No Acc No Acc. -2.05 3.17 2.92 2.26 -3.71 -4.16 -6.95 3.68 3.05 2.05 -2.17 -2.39 -3.06 2.57 2.30 2.27 2.12 2.10 2.06 -2.47 -2.84 9.77 5.33 2.91 2.86 2.79 2.59 2.04 2.00 -2.03 -2.58 -2.59 Cu Cu Cu Cd Cd Cd Cu Cu Cu Cd Cd Cd Identity6 (P80961) Antifreeze protein LS-12 precursor Type-4 ice-structuring protein precursor (Antifreeze protein type IV) (P29788) Vitronectin precursor (Serum spreading factor) (S- protein) (P14527) Hemoglobin alpha-4 subunit (Hemoglobin alpha-4 chain) (Alpha-4-globin) (P02019) Hemoglobin alpha-1 subunit (Hemoglobin alpha-1 chain) (Alpha-1-globin) (P02142) Hemoglobin beta-1 subunit (Q01584) Lipocalin precursor isocitrate dehydrogenase 2 (NADP+) mitochondrial (Q9N2D5) Glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) (GAPDH) Bos taurus mono(ADP-ribosyl)transferase (ART1) mRNA (P48163) NADP-dependent malic enzyme (EC 1.1.1.40) (NADP-ME) (Malic enzyme1) glyoxalase 1 (Q8BH95) Enoyl-CoA hydratase mitochondrial precursor (EC 4.2.1.17) ABCu (P06761) 78 kDa glucose-regulated protein precursor (GRP 78) (BiP) ABCu DnaJ-like subfamily B member 11 Cu (P08110) Endoplasmin precursor (Heat shock 108 kDa protein) (Transferrin-binding protein) ACu (P30710) Epididymal secretory glutathione peroxidase precursor (EC 1.11.1.9) Cu glutathione peroxidase 3 Cu (O57521) Heat shock protein HSP 90-beta Cu (P08294) Extracellular superoxide dismutase [Cu-Zn] precursor (EC 1.15.1.1) ACd thioredoxin interacting protein Cd (Q4AEH7) Glutathione peroxidase 2 (EC 1.11.1.9) Cu (Q9ES30) Complement C1q tumor necrosis factor-related protein 3 precursor Cu C-type MBL-2 protein Cu (Q02988) Lectin precursor ABCu (P27797) Calreticulin precursor (CRP55) (Calregulin) ABCu similar to catechol-O-methyltransferase domain containing 1 ABCu precerebellin-like protein Cu (Q9WUW3) Complement factor I precursor (EC 3.4.21.45) (C3B/ C4B inactivator) ACu (O88803) Leukocyte cell-derived chemotaxin 2 precursor Cd (Q801Y3) Hepcidin 1 precursor Cd liver-expressed antimicrobial peptide 2 isoform A precursor ACd (P04186) Complement factor B precursor (EC 3.4.21.47)