Martin et al. BMC Genomics 2010, 11:418 http://www.biomedcentral.com/1471-2164/11/418 Page 12 of 20 Table 5 GO Biological processes significantly altered in infected fish depending on prior feeding regime GO Identifier1 Term2 q3 m4 Immune related GO:0002376 immune system process 9 135 GO:0009605 response to external stimulus 9 137 GO:0006952 defense response 8 110 GO:0006954 inflammatory response 7 70 GO:0002253 activation of immune response 4 25 GO:0006956 complement activation 4 22 GO:0002526 acute inflammatory response 6 39 GO:0048583 regulation of response to stimulus 5 52 GO:0002541 activation of plasma proteins involved in acute inflammatory response 4 22 GO:0006959 humoral immune response 4 28 GO:0002684 positive regulation of immune system process 4 30 GO:0048584 positive regulation of response to stimulus 4 29 GO:0050776 regulation of immune response 4 35 GO:0050778 positive regulation of immune response 4 26 Protein metabolism GO:0016485 GO:0051604 GO:0051605 GO:0032880 GO:0051222 GO:0070201 GO:0051223 GO:0060341 GO:0045786 protein processing protein maturation protein processing by peptide bond cleavage regulation of protein localization positive regulation of protein transport regulation of establishment of protein localization regulation of protein transport regulation of cellular localization negative regulation of cell cycle Lipid and glycerol metabolism GO:0045834 positive regulation of lipid metabolic process GO:0006638 neutral lipid metabolic process GO:0006639 acylglycerol metabolic process GO:0006641 triglyceride metabolic process GO:0006662 glycerol ether metabolic process GO:0018904 organic ether metabolic process Cellular homeostasis GO:0048518 GO:0032879 GO:0051239 GO:0050793 GO:0022603 GO:0051094 GO:0045766 GO:0045765 GO:0051049 GO:0051272 GO:0051050 GO:0030334 positive regulation of biological process regulation of localization regulation of multicellular organismal process regulation of developmental process regulation of anatomical structure morphogenesis positive regulation of developmental process positive regulation of angiogenesis regulation of angiogenesis regulation of transport positive regulation of cellular component movement positive regulation of transport regulation of cell migration 4 4 4 3 3 3 3 3 3 3 3 3 3 3 3 13 7 6 6 6 5 5 5 4 3 3 3 31 32 29 12 12 12 12 20 22 20 8 8 7 8 8 242 53 63 41 27 19 14 19 33 11 16 17 p5 0.08 0.08 0.08 0.03 0.03 0.02 0.01 0.08 0.02 0.04 0.04 0.04 0.08 0.04 0.05 0.06 0.04 0.02 0.02 0.02 0.02 0.07 0.08 0.07 0.00 0.00 0.00 0.00 0.00 0.10 0.01 0.05 0.01 0.00 0.00 0.00 0.00 0.07 0.01 0.04 0.04