BMC Cancer 2005, 5:111 http://www.biomedcentral.com/1471-2407/5/111 AC provide assistance with patients diagnoses undergone TRUS-guided-prostate biopsy and collection of specimens and clinical date. VG provide assistance with patients diagnoses and collec- tion of specimens and clinical data, and supervised all aspect of the work performed for this paper in the Depart- ment of Urology, Rome "La Sapienza" University. LG provided collection of specimens and clinical data, and assisted with data analysis. SM provided assistance with patient diagnoses and with data analysis. FDS provided assistence with patients undergone surgery, collection of specimens and clinical data, and supervised all aspect of the work performed for this paper in the Department of Urology, Rome "La Sapienza" University. 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