Picano et al. BMC Cancer 2012, 12:157 http://www.biomedcentral.com/1471-2407/12/157 28. Preston DL, Ron E, Yonehara S, Kobuke T, Fujii H, Kishikawa M, Tokunaga M, Tokuoka S, Mabuchi K: Tumors of the nervous system and pituitary gland associated with atomic bomb radiation exposure. J Natl Cancer Inst 2002, 94:1555–1563. 29. Alexander V, DiMarco JH: Reappraisal of brain tumor risk among U.S. nuclear workers: a 10-year review. Occup Med 2001, 16:289–315. 30. Center for Environmental health studies: Cancer and workers exposed to ionizing radiation. A review of the research literature.: ; 2003. http://www.jsi. com (accessed November 10th, 2011). 31. Zeeb H, Hammer GP, Langner I, Schafft T, Bennack S, Blettner M: Cancer mortality among German aircrew: second follow-up. Radiat Environ Biophys 2010, 49:187–194. 32. Matanoski GM, Seltser R, Sartwell PE, Diamond EL, Elliott EA: The current mortality rates of radiologists and other physician specialists: specific causes of death. Am J Epidemiol 1975, 101:199–210. 33. Wang JX, Inskip PD, Boice JD Jr, Li BX, Zhang JY, Fraumeni JF Jr: Cancer incidence among medical diagnostic X-ray workers in China, 1950 to 1985. Int J Cancer 1990, 45:889–895. 34. Andersson M, Engholm G, Ennow K, Jessen KA, Storm HH: Cancer risk among staff at two radiotherapy departments in Denmark. Br J Radiol 1991, 64:455–460. 35. Carozza SE, Wrensch M, Miike R, et al: Occupation and adult gliomas. Am J Epidemiol 2000, 152:838–846. 36. Andersen A, Barlow L, Engeland A, Kjærheim K, Lynge E, Pukkala E: Work-related cancer in the Nordic countries. Scand J Work Environ Health 1999, 25:1–116. 37. Hardell L, Mild KH, Påhlson A, Hallquist A: Ionizing radiation, cellular telephones and the risk for brain tumours. Eur J Cancer Prev 2001, 10:523–529. 38. Blettner M, Schlehofer B, Samkange-Zeeb F, Berg G, Schlaefer K, Schüz J: Medical exposure to ionising radiation and the risk of brain tumours: Interphone study group, Germany. Eur J Cancer 2007, 43:1990–1998. 39. Finkelstein MM: Is brain cancer an occupational disease of cardiologists? Can J Cardiol 1998, 14:1385–1388. 40. Roguin A, Goldstein J, Bar O: Brain tumors among Interventional Cardiologists – a call for alarm? Eurointerv 2012, 7:1081–1086. 41. Wenzl TB: Increased brain cancer risk in physicians with high radiation exposure. Radiology 2005, 235:709–710. 42. Yoshinaga S, Mabuchi K, Sigurdson AJ, Doody MM, Ron E: Reply to Wenzl TB. Cancer risks among radiologists and radiologic technologists: review of epidemiologic studies. Radiology 2004, 233:313–321. 43. Plummer C, Henderson RD, O'Sullivan JD, Read SJ: Ischemic Stroke and Transient Ischemic Attack After Head and Neck Radiotherapy: A Review. Stroke 2011, 42:2410–2418. 44. McGale P, Darby SC: Commentary: a dose–response relationship for radiation-induced heart disease–current issues and future prospects. Int J Epidemiol 2008, 37:518–523. 45. Little MP: Cancer and non-cancer effects in Japanese atomic bomb survivors. J Radiol Prot 2009, 29:A43–A59. 46. Metz-Flamant C, Bonaventure A, Milliat F, Tirmarche M, Laurier D, Bernier MO: Low doses of ionizing radiation and risk of cardiovascular disease: A review of epidemiological studies. Rev Epidemiol Sante Publique 2009, 57:347–359. 47. Little MP, Kleinerman RA, Stovall M, Smith SA, Mabuchi K: Analysis of dose response for circulatory disease after radiotherapy for benign disease. Int J Radiat Oncol Biol Phys 2012 Apr 10. 48. Schultz-Hector S, Trott KR: Radiation-induced cardiovascular diseases: is the epidemiologic evidence compatible with the radiobiologic data? Int J Radiat Oncol Biol Phys 2007, 67:10–18. 49. Yamada M, Naito K, Kasagi F, Masunari N, Suzuki G: Prevalence of atherosclerosis in relation to atomic bomb radiation exposure: an RERF Adult Health Study. Int J Radiat Biol 2005, 81:821–826. 50. Sasaki H, Wong FL, Yamada M, Kodama K: The effects of aging and radiation exposure on blood pressure levels of atomic bomb survivors. J Clin Epidemiol 2002, 55:974–981. 51. Wong FL, Yamada M, Sasaki H, Kodama K, Hosoda Y: Effects of radiation on the longitudinal trends of total serum cholesterol levels in the atomic bomb survivors. Radiat Res 1999, 151:736–746. 52. Neriishi K, Nakashima E, Delongchamp RR: Persistent subclinical inflammation among A-bomb survivors. Int J Radiat Biol 2001, 77:475–482. Page 12 of 13 53. Hayashi T, Kusunoki Y, Hakoda M, Morishita Y, Kubo Y, Maki M, Kasagi F, Kodama K, Macphee DG, Kyoizumi S: Radiation dose-dependent increases in inflammatory response markers in A-bomb survivors. Int J Radiat Biol 2003, 79:129–136. 54. Stewart FA, Hoving S, Russell NS: Vascular damage as an underlying mechanism of cardiac and cerebral toxicity in irradiated cancer patients. Radiat Res 2010, 174:865–869. 55. Dogan I, Sezen O, Sonmez B, Zengin AY, Yenilmez E, Yulug E, Abidin I, Bahat Z: Myocardial perfusion alterations observed months after radiotherapy are related to the cellular damage. Nuklearmedizin 2010, 49:209–215. 56. Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, Launer LJ, Laurent S, Lopez OL, Nyenhuis D, Petersen RC, Schneider JA, Tzourio C, Arnett DK, Bennett DA, Chui HC, Higashida RT, Lindquist R, Nilsson PM, Roman GC, Sellke FW, Seshadri S, on behalf of the American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council on Cardiovascular Nursing, Council on Cardiovascular Radiology and Intervention, and Council on Cardiovascular Surgery and Anesthesia: Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2011, 42:2672–2713. 57. Scuteri A, Nilsson PM, Tzourio C, Redon J, Laurent S: Microvascular brain damage with aging and hypertension: pathophysiological consideration and clinical implications. J Hypertens 2011, 29:1469–1477. 58. Tomei F, Papaleo B, Fantini S, Iavicoli S, Baccolo TP, Rosati MV: Vascular effects of occupational exposure to low-dose ionizing radiation. Am J Ind Med 1996, 30:72–77. 59. Fike JR, Cann CE, Turowski K, Higgins RJ, Chan AS, Phillips TL, Davis RL: Radiation dose response of normal brain. Int J Radiat Oncol Biol Phys 1988, 14:63–70. 60. Douw L, Klein M, Fagel SS, van den Heuvel J, Taphoorn MJ, Aaronson NK, Postma TJ, Vandertop WP, Mooij JJ, Boerman RH, Beute GN, Sluimer JD, Slotman BJ, Reijneveld JC, Heimans JJ: Cognitive and radiological effects of radiotherapy in patients with low-grade glioma: long-term follow-up. Lancet Neurol 2009, 8:810–818. 61. Lyubimova N, Hopewell JW: Experimental evidence to support the hypothesis that damage to vascular endothelium plays the primary role in the development of late radiation-induced CNS injury. Br J Radiol 2004, 77:488–492. 62. Panagiotakos G, Alshamy G, Chan B, Abrams R, Greenberg E, Saxena A, Bradbury M, Edgar M, Gutin P, Tabar V: Long-term impact of radiation on the stem cell and oligodendrocyte precursors in the brain. PLoS One 2007, 2:e588. 63. Gilmore SA, Phillips N, Liu KM, Houlé JD: Radiation-induced modulation of the microglial population in the normal and injured mature spinal cord. Exp Neurol 2003, 182:169–179. 64. Mizumatsu S, Monje ML, Morhardt DR, Rola R, Palmer TD, Fike JR: Extreme sensitivity of adult neurogenesis to low doses of X-irradiation. Cancer Res 2003, 63:4021–4027. 65. Ma DK, Bonaguidi MA, Ming GL, Song H: Adult neural stem cells in the mammalian central nervous system. Cell Res 2009, 19:672–682. 66. Doty RL: The olfactory system and its disorders. Semin Neurol 2009, 29:74–81. 67. Peissner W, Kocher M, Treuer H, Gillardon F: Ionizing radiation-induced apoptosis of proliferating stem cells in the dentate gyrus of the adult rat hippocampus. Brain Res Mol Brain Res 1999, 71:61–68. 68. Kanzawa T, Iwado E, Aoki H, Iwamaru A, Hollingsworth EF, Sawaya R, Kondo S, Kondo Y: Ionizing radiation induces apoptosis and inhibits neuronal differentiation in rat neural stem cells via the c-Jun NH2-terminal kinase (JNK) pathway. Oncogene 2006, 25:3638–3648. 69. Verheyde J, Benotmanea MA: Unraveling the fundamental molecular mechanisms of morphological and cognitive defects in the irradiated brain. Brain Res Rev 2007, 53:312–320. 70. Silasi G, Diaz-Heijtz R, Besplug J, Rodriguez-Juarez R, Titov V, Kolb B, Kovalchuk R: Selective brain responses to acute and chronic low-dose X- ray irradiation in males and females. Biochem Biophys Res Commun 2004, 325:1223–1235. 71. Raber J, Rola R, LeFevour A, Morhardt D, Curley J, Mizumatsu S, VandenBerg SR, Fike JR: Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis. Radiat Res 2004, 162:39–47. 72. Drew MR, Denny CA, Hen R: Arrest of adult hippocampal neurogenesis in mice impairs single- but not multiple-trial contextual fear conditioning.