Koizumi et al. BMC Cancer 2010, 10:423 http://www.biomedcentral.com/1471-2407/10/423 Page 6 of 9 Figure 3 Kaplan-Meier curves for skeletal-related events (SRE) in patients with and without pain. Starting point was the date of initial surgery. SRE fractions are presented for skeletal metastasis patients without pain (black line) and with pain (gray line). A log-rank test demonstrated a statistically significant difference between the two groups (p < 0.001). Starting point was the date of initial surgery. Figure 4 Kaplan-Meier curves for survival (cause-specific death, CSD) in patients with and without pain. Starting point was the date of initial surgery. CSD fractions are presented for patients without pain (black line) and with pain (gray line). A log-rank test demonstrated a statistically significant difference between the two groups (p = 0.07). Starting point was the date of initial surgery.