Yamamoto et al. BMC Genomics 2012, 13:335 http://www.biomedcentral.com/1471-2164/13/335 Page 6 of 15 Figure 3 Hierarchical cluster analysis of the 1498 differentially-expressed genes in the LI. Expression was increased or decreased at a significance level of p < 0.05. Gene tree (Pearson correlation: left tree) shows correlated groups of genes and their expression patterns across all individual samples (top axis). The 5 groups highlight the separation of the gene clusters. MGP analysis was performed for each cluster and the top 1 ~ 3 GO categories (BP, MF, or/and CC) were listed. Colors show the range of expression from blue (decreased expression) to yellow (increased expression). Figure 4 Hierarchical cluster analysis of the 2711 differentially-expressed genes in the SI. Expression was increased or decreased at a significance level of p < 0.05. Gene tree (Pearson correlation: left tree) shows correlated groups of genes and their expression patterns across all individual samples (top axis). The 6 groups highlight the separation of the gene clusters. MGP analysis was performed for each cluster and the top 1 ~ 3 GO categories (BP, MF, or/and CC) were listed. Colors show the range of expression from blue (decreased expression) to yellow (increased expression).