user: text: Write a concise one-sentence TLDR summary of the scientific paper content below.

Title: Generative Models for Graph-Based Protein Design

Paper content:
Engineered proteins offer the potential to solve many problems in biomedicine, energy, and materials science, but creating designs that succeed is difficult in practice.
A significant aspect of this challenge is the complex coupling between protein sequence and 3D structure, and the task of finding a viable design is often referred to as the inverse protein folding problem.
We develop generative models for protein sequences conditioned on a graph-structured specification of the design target.
Our approach efficiently captures the complex dependencies in proteins by focusing on those that are long-range in sequence but local in 3D space.
Our framework significantly improves upon prior parametric models of protein sequences given structure, and takes a step toward rapid and targeted biomolecular design with the aid of deep generative models.
A central goal for computational protein design is to automate the invention of protein molecules with defined structural and functional properties.
This field has seen tremendous progess in the past two decades BID14 , including the design of novel 3D folds BID20 , enzymes BID30 , and complexes BID4 .
However, the current practice often requires multiple rounds of trial-and-error, with first designs frequently failing BID19 BID28 .
Several of the challenges stem from the bottom-up nature of contemporary approaches that rely on both the accuracy of energy functions to describe protein physics as well as on the efficiency of sampling algorithms to explore the protein sequence and structure space.Here, we explore an alternative, top-down framework for protein design that directly learns a conditional generative model for protein sequences given a specification of the target structure, which is represented as a graph over the sequence elements.
Specifically, we augment the autoregressive self-attention of recent sequence models BID34 with graph-based descriptions of the 3D structure.
By composing multiple layers of structured self-attention, our model can effectively capture higher-order, interaction-based dependencies between sequence and structure, in contrast to previous parameteric approaches BID24 BID36 that are limited to only the first-order effects.The graph-structured conditioning of a sequence model affords several benefits, including favorable computational efficiency, inductive bias, and representational flexibility.
We accomplish the first two by leveraging a well-evidenced finding in protein science, namely that long-range dependencies in sequence are generally short-range in 3D space BID23 BID3 .
By making the graph and self-attention similarly sparse and localized in 3D space, we achieve computational scaling that is linear in sequence length.
Additionally, graph structured inputs offer representational flexibility, as they accomodate both coarse, 'flexible backbone' (connectivity and topology) as well as fine-grained (precise atom locations) descriptions of structure.We demonstrate the merits of our approach via a detailed empirical study.
Specifically, we evaluate our model at structural generalization to sequences of protein folds that were outside of the training set.
Our model achieves considerably improved generalization performance over the recent deep models of protein sequence given structure as well as structure-naïve language models.
We presented a new deep generative model to 'design' protein sequences given a graph specification of their structure.
Our model augments the traditional sequence-level self-attention of Transformers BID34 with relational 3D structural encodings and is able to leverage the spatial locality of dependencies in molecular structures for efficient computation.
When evaluated on unseen folds, the model achieves significantly improved perplexities over the state-of-the-art parametric generative models.
Our framework suggests the possibility of being able to efficiently design and engineer protein sequences with structurally-guided deep generative models, and underscores the central role of modeling sparse long-range dependencies in biological sequences.

assistant: text: We learn to conditionally generate protein sequences given structures with a model that captures sparse, long-range dependencies.