Exhibit 10.3


 


iNHiBIKASE
THERAPEUTICS


 


FIRST
AMENDMENT TO

COLLABORATIVE RESEARCH AND DEVELOPMENT AGREEMENT


 


THIS
FIRST AMENDMENT TO THE COLLABORATIVE RESEARCH AND DEVELOPMENT AGREEMENT (“Agreement”) is entered into with
an effective date as of the 5th day of October 2012 (the “Amendment Effective Date”) by and among, on the
one hand, Inhibikase Therapeutics, Inc., a Delaware corporation, with offices located at 3350 Riverwood Parkway, Suite 1927, Atlanta,
Georgia (the “Company”) and, on the other hand, Sphaera Pharma Pte. Ltd., a company incorporated under the laws of
Singapore with its registered office at 8 Temasek Boulevard, #22-03 Suntec Tower 3, Singapore 038988 (“Sphaera Singapore”)
and Sphaera Phanna Pvt. Ltd., with its registered office at E-375, First Floor, Greater Kailash-II, New Delhi-110048, INDIA (“Sphaera
India”)(together with Sphaera Singapore, hereinafter referred to as “Sphaera Pharma”). (Company and Sphaera Pharma
shall be referred to individually as a “Party” and collectively as the “Parties.”) Except as otherwise
provided in this Agreement, capitalized terms and phrases shall have the meaning ascribed thereto in the Original Agreement (as
defined below)


 


RECITALS


 


WHEREAS,
Sphaera Pharma and Company entered into that certain Collaborative Research and Development Agreement as of the 29 day
of February 2012 (the “Original Agreement”) to address, among other things, certain issues relating to the Company
Compounds (as defined below);


 


WHEREAS,
since having entered into the Original Agreement, each of Sphaera Phanna and Company agreed to file the Joint Applications
(as defined below) on the Company Compounds and Sphaera Compounds (as defined below);


 


 


 


	WHEREAS,
each of the Parties desire to enter into this Agreement for the purpose of amending the Original Agreement to address, among other
things, the Parties' relative rights to the Joint Applications;


 


NOW
THEREFORE, in consideration of the mutual covenants and promises herein, the receipt and sufficiency of which are hereby
acknowledged, Sphaera Pharma and Company agree as follows:


 


1.                 
Amendment. Each of Sphaera Pharma and Company hereby agree that the Original Agreement is and shall be amended by adding
at the end of Section 4 the following provisions in sequential order thereto:






 


a.                  
The Joint Applications. Sphaera Pharma and Company jointly filed intellectual property under application number 61/709704
in the United States on 4 October, 2012 and under application number 3105/DEL/2012 in India on 4 October, 2012 (“the Joint
Applications”). The intellectual property covered by the Joint Applications as filed in the United States and India includes
a series of novel compounds. The representative novel compounds covered by the Joint Applications appear in Table 1 thereto (“Table
1”).


 






     


     


    

 


b.                 
The Company Compounds. Under and for purposes of the Original Agreement, specifically compounds 101 thru 113 of the
isomer represented by Formula III described on Table 1 (hereinafter the “Company Compounds”) constitute Project Results
and/or Project Improvements (as such phrases are defined under the Original Agreement) and, as a result thereof, the sole and exclusive
property of Company, with any and all right title and interest in and to the Company Compounds and all methods and compositions
relating specifically to such Company Compounds being both subject to the terms of the Original Agreement and hereby assigned to
Company.


 


c.                  
The Sphaera Compounds. All other compounds envisioned, implied or subsumed within the Joint Application as isomers
represented by Formula III or Formula IV, including compounds 114 thru 120 described on Table 1, are not subject to the Original
Agreement, but are owned by Sphaera (hereinafter, the “Sphaera Compounds”), with any and all right, title, and interest
to the Sphaera Compounds being held by Sphaera Pharma.


 


d.                 
Patent Ownership and Cooperation.


 


i.                   
The Mixed Patents. The Parties agree that the Mixed Patents (as defined below), including, without limitation, the Joint
Applications, will be jointly owned by both Parties.


 


ii.                 
Cooperation. Sphaera Pharma and Company therefore agree to cooperate in good faith to conduct prosecution of any patent
applications claiming priority to the Joint Applications to obtain patents, to be solely owned by Company, that specifically claim
inventions related to the Company Compounds (as represented by, for example, claim 22 of 61/709704, solely to the extent that A
is a moiety selected from 101-113, and claims 25-27 and 29-36 solely to the extent they depend from claim 22 and where A
is a moiety selected from 101-113), to the extent requested by Company and to the extent reasonably practicable, on a jurisdiction-by-jurisdiction
basis, without negatively impacting Sphaera Pharma’s ability to protect inventions related to the Sphaera Compounds. Ownership
of any other patent applications claiming priority to the Joint Applications shall be determined according to inventorship as determined
under U.S. law. With respect to the Joint Applications and any patents and patent applications arising from or claiming priority
to the Joint Applications and whose claims encompass both Company Compounds and Sphaera Compounds (“Mixed Patents”),
the Parties agree to cooperate in good faith in prosecution, enforcement, and other activities relating to the Mixed Patents and
to the commercialization of Company Compounds and Sphaera Compounds. Sphaera Pharma and Company agree to exchange materials, know-how
and to act jointly to collect data useful to support the specification of the Joint Applications prior to September 15,2013.


 


e.                  
Cross Licenses.


 


i.                   
By Sphaera Pharma. Sphaera Pharma grants to Company an exclusive (even as to Sphaera), worldwide, royalty-free, fully paid-up
license to the Mixed Patents and any and all know how and materials controlled by Sphaera Pharma relating thereto and useful in
the practice thereof to make, Develop, use, sell, offer to sell, and otherwise exploit Company Compounds and related compositions
and methods for the period commencing with the Amendment Effective Date and ending on the later to occur of the expiration of the
last valid claim covering Company Compounds and related compositions and methods or the 15th anniversary of the Amendment
Effective Date; provided, however, that such license is subject to Section 10 of the Original Agreement.


 






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ii.                 
By Company. Company grants to Sphaera Pharma an exclusive (even as to Company), worldwide, royalty-free, fully paid-up license
to the Mixed Patents and any and all know how and materials controlled by Company relating thereto and useful in the practice thereof
to make, Develop, use, sell, offer to sell, and otherwise exploit Sphaera Compounds and related compositions and methods for the
period commencing with the Amendment Effective Date and ending on the later to occur of the expiration of the last valid claim
covering Company Compounds and related compositions and methods or the 15th anniversary of the Amendment Effective Date
(the “Term”); provided, however, that Sphaera Pharma hereby grants to Company a right of first offer to license
for the Term exclusively under the Mixed Patents and know-how and materials relating thereto and useful in the practice thereof
from Sphaera Pharma the right to make, use, sell, offer to sell, and otherwise exploit any such Sphaera Compound and related compositions
and methods only within the field of infectious disease, the terms of which license both parties agree to use commercially reasonable
efforts to negotiate in good faith and which shall be on customary terms and conditions for licenses of similar intellectual property.
To the extent Company wishes to obtain a license to the Mixed Patents to make, use, sell, or offer to sell any of the Sphaera Compounds
(i.e., compounds 114-120 of Table 1, or any other compound envisioned, implied or subsumed within the applications 61/709704
in the United States and 3105/DEL/2012 in India filed on 4 October, 2012, other than the Company Compounds), such a license will
require an agreement and acceptance by Sphaera Pharma; for purposes of such license, the financial terms and conditions thereof
shall be negotiated by the parties, with Article 2, entitled “Consideration of Services,” of the Original Agreement
having applicability to only the Company Compounds. For the purpose of clarity, except as otherwise provided in this Section (e)(ii),
Sphaera Pharma may use the Sphaera Compounds outside the scope of the Original Agreement without restriction and without any further
approval or agreement from Company.


 


f.                   
No Overlap in Commercial Pursuits.


 


i.                   
Section 10(e) of the Original Agreement provides, in pertinent part, “that Sphaera Pharma will have the right to develop
the Company Compounds for use in the treatment of cancer in humans,” but as provided in Section 10(a) may not commercialize
any of the Company Compounds until and unless Company delivers an Abandonment Notice (as defined in the Original Agreement) and
otherwise complies with Section 10 thereof. Subject to the foregoing, Section 10(e) is hereby amended (but is not otherwise modified)
to add as the last sentence thereof the following:


 


“(a) Company shall neither
undertake to Develop nor Develop or, if in the process of Developing, shall cease developing any one of the Company Compound for
which Company is notified in writing by Sphaera Pharma that Sphaera Pharma has filed an IND on such Company Compound for a cancer
indication in humans, and (b) Sphaera Pharma shall neither undertake to Develop nor Develop or, if it in the process of Developing,
shall cease Developing any Company Compound for which Sphaera Pharma is notified in writing that an IND has been filed for such
Company Compound, which limitation shall remain in effect for the period during which such Development remains continuously active.
As such, each of the Parties agrees to provide to the other written notice of it determining to both (y) choose as a lead candidate
for Development one of the Company Compounds and, as a result thereof, (z) commence IND-enabling studies for the purpose of filing
an IND, which notice shall be delivered to the other Party within ten (10) consecutive calendar days of any such determination.
For purposes of this section, “Development” or “Develop” shall mean those activities relating to non- clinical
and clinical research and drug development, including, without limitation, toxicology, pharmacology and other discovery efforts,
test method development and stability testing, process development, formulation development, delivery system development, quality
assurance and quality control development, statistical analysis, clinical studies or trials (including pre-approval studies and
investigator sponsored clinical studies or trials), regulatory affairs and clinical study or trial regulatory activities (excluding,
however, regulatory activities directed to obtaining pricing and reimbursement approvals and activities constituting manufacturing,
marketing, sales, distribution or other commercialization); and “IND” shall mean an investigational new drug application
filed with the U.S. Food and Drug Administration (“FDA”) or any equivalent filing with any governmental agency having
regulatory authority similar to that of the FDA for a jurisdiction other than the U.S.”


 


 


ii.                 
Unless and until expansion of the Original Agreement is executed between the parties, Company cannot and will not pursue
any development of the Sphaera Compounds 114-120 of Table 1.


 






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2.                 
Binding and Enforceable Agreement; Entirety of Agreement. The terms of this Agreement shall be binding upon,
and shall inure to the benefit of each of the Parties hereto and their respective successors, heirs and assigns. This Agreement
shall be considered an integral part of the Original Agreement and shall be binding upon each Party from the date first above written.
Subject only to the modifications referred to in this Agreement, the Original Agreement shall remain in full force and effect and
where necessary shall be read and construed and be enforceable as if the terms of this Agreement were inserted therein.


 


3.                 
Fulfillment of Original Agreement.


 


a.                  
Each of the Parties hereby acknowledges that the Services as contemplated under the Original Agreement have been completed
and as of the Amendment Effective Date are terminated; except, however, that Company remains obligated to fulfill
its financial obligations agreed to under Section 2 of the Original Agreement More specifically, as of the date hereof, the Project
Fixed Fee (as defined under the Original Agreement) equals in total the amount of SI60,000 for the synthesis and analysis of Company
Compounds remain due and payable by Company. Each Party hereby acknowledges that the Project Variable Fees have been paid in full.


 


b.                 
Failure by Company to pay the Project Fixed Fees by the first anniversary of the Amendment Effective Date may constitute
grounds for termination of the Original Agreement in accordance with Article 12 thereof, but shall not otherwise affect the rights
of the Parties as described thereunder or under this Agreement.


 


4.                 
Counterparts. This Agreement may be executed in several counterparts, each of which shall be deemed an original,
but together they shall constitute one and the same instrument.


 


[Signatures continued on next page.]


 






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IN WITNESS WHEREOF,
the parties have caused this Agreement to be executed by their duly authorized representatives.


 


	Sphaera Singapore

Sphaera Pharma Plc. Ltd.	 	Inhibikase Therapeutics, Inc.
	 	 	 
	/s/ Sundeep Dugar  	 	/s/ Milton H. Werner  
	Signature  	 	Signature  
	 	 	 
	Sundeep Dugar, PhD	 	Milton H. Werner, PhD
	Printed Name	 	Printed Name
	 	 	 
	President & CEO	 	President & CEO
	Title	 	Title
	 	 	 
	April 12, 2013    	 	April 5, 2013
	Date	 	Date
	 	 	 
	Sphaera India

Sphaera Pharma Pvt. Ltd.	 	Read and acknowledged by

Project Coordinator, Sphaera Pharma:
	 	 	 
	/s/ Abhinav Dhandia  	 	/s/ Frank P. Hollinger  
	Signature  	 	Signature  
	 	 	 
	Abhinav Dhandia

Printed Name  	 	Frank P. Hollinger, PhD

Printed Name
	 	 	 
	Assoc. Dir – Corporate

Affairs & Business Dev.

Title  	 	Vice President

Title  
	 	 	 
	April 11,2013  	 	April 6, 2013  
	Date  	 	Date  


 






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