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     As filed with the Securities and Exchange Commission on November 18, 2003

                    Registration Statement No. 333-__________
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION

                               450 5TH STREET N.W.

                             WASHINGTON, D.C. 20549

                                   ----------

                                    FORM S-8

                             REGISTRATION STATEMENT

                                      UNDER

                           THE SECURITIES ACT OF 1933

                                   ----------

                                   **PFIZER INC.**
             (Exact name of Registrant as specified in its charter)

        DELAWARE                                         13-5315170
(State of Incorporation)                    (I.R.S. Employer Identification No.)

                              235 EAST 42ND STREET
                          NEW YORK, NEW YORK 10017-5755
                    (Address of Principal Executive Offices)

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                 PFIZER CANADA INC. SAVINGS AND INVESTMENT PLAN                           (Full Title of the Plan)
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                             MARGARET M. FORAN, ESQ.
                                   PFIZER INC.
                              235 EAST 42ND STREET
                          NEW YORK, NEW YORK 10017-5755
                    (Name and Address of Agent for Services)

                                 (212) 773-4802
                     (Telephone Number of Agent for Service)

                                   ----------

                           CALCULATION OF REGISTRATION FEE
=========================================================================================
     TITLE OF       AMOUNT TO BE     PROPOSED MAXIMUM    PROPOSED MAXIMUM      AMOUNT OF
 SECURITIES TO BE    REGISTERED(2)  OFFERING PRICE PER       AGGREGATE       REGISTRATION
   REGISTERED(1)                         SHARE(3)        OFFERING PRICE(3)      FEE(3)
-----------------------------------------------------------------------------------------
Common Stock, $.05   500,000 shares.       $31.94        $15,970,000.00   $1,291.98
par value
===========================================================================================

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1    Includes Pfizer Preferred Stock purchase rights that, until events
     specified in Pfizer's Rights Agreement occur, will not be exercisable or
     evidenced separately from the common stock.

2    Pursuant to Rule 416(c) under the Securities Act of 1933, this
     registration statement also covers additional securities that may be offered      as a result of stock splits, stock dividends or similar transactions, and pursuant
     to Rule 416(c) also covers an indeterminate amount of interests to be offered or
     sold pursuant to the employee benefit plan described herein.

3    Estimated to calculate the registration fee based on the average of the
     high and low prices of Pfizer Inc. Common Stock for New York Stock Exchange
     Composite Transactions as reported in The Wall Street Journal on November 17, 2003.
================================================================================

                                    PART II.

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE

      The following are incorporated by reference:

      o     the Annual Report of Pfizer Inc. on Form 10-K for the year ended
            December 31, 2002,

      o     all other reports we subsequently filed under Sections 13(a) or
            15(d) of the Securities Exchange Act of 1934,and

      o     the description of our common stock contained in our Registration
            Statement filed under Section 12 of the Securities Exchange Act of
            1934, including all amendments and reports updating the description,

      o     the Annual Report of Pharmacia Corporation on Form 10-K for the year ended
            December 31, 2002.

      All documents later filed by us under Section 13(a), 13(c), 14, and 15(d)
of the Securities Exchange Act of 1934, before we file a post-effective
amendment that indicates all securities offered have been sold or which
deregisters all securities that have not been sold, will be incorporated by
reference and will be a part of this filing from the date that document was
filed.

ITEM 4. DESCRIPTION OF SECURITIES

      Not applicable.

ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL

      The validity of the securities has been passed upon by Margaret M. Foran,
Esq., Vice President - Corporate Governance and Secretary for the Company. Ms.
Foran beneficially owns Common Stock and options to purchase Common Stock
granted under the Pfizer Inc. Stock and Incentive Plan.

ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS

      Section 145 of the General Corporation Law of Delaware permits a
corporation to indemnify any person who is or has been a director, officer,
employee or agent of the corporation or who is or has been serving as director,
officer, employee or agent of another corporation, organization or enterprise at
the request of the corporation, against all liability and expenses (including,
but not limited to, attorneys' fees and disbursements and amounts paid in
settlement or in satisfaction of judgments or as fines or penalties) incurred or
paid in connection with any claim, action, suit or proceeding, whether civil,
criminal, administrative, investigative or otherwise, in which he/she may be
involved by reason of the fact that he/she served or is serving in these
capacities, if he/she acted in good faith and in a manner he/she reasonably
believed to be in or not opposed to the best interest of the corporation and,
with respect to any criminal action or proceeding, had no cause to believe
his/her conduct was unlawful. In the case of a claim, action, suit or proceeding
made or brought by or in the right of the corporation to procure a recovery or
judgment in its favor, the corporation shall not indemnify such person in
respect of any claim, issue or matter as to which such person has been adjudged
to be liable to the corporation for negligence or misconduct in the performance
of his/her duty to the corporation, except for such expenses as the court may
allow. Any such person who has been wholly successful on the merits or otherwise
with respect to any such claim, action, suit or proceeding or with respect to
any claim, issue or matter therein, shall be indemnified as of right against all
expenses in connection therewith or resulting therefrom.

      Pursuant to Article V, Section 1 of our By-Laws, we will indemnify
directors and officers to the fullest extent permitted by applicable law as it
presently exists or is amended. We are insured against actions taken under our By-Laws and the directors and officers are insured directly at our expense against such liabilities for which indemnification is not made. We have entered into agreements with our directors and certain of our officers requiring us to indemnify such persons to the fullest extent permitted by our By-Laws.

ITEM 7. EXEMPTION FROM REGISTRATION CLAIMED

      Not applicable.

ITEM 8. EXHIBITS

EXHIBIT

 5      --    Opinion and Consent of Margaret M. Foran, Esq., Vice President -
              Corporate Governance and Secretary.

23  (i) --    Consent of KPMG LLP, independent auditors.

23 (ii) --    Consent of PriceWaterhouseCoopers LLP, independent accountants.

23(iii) --    Consent of Deloitte & Touche LLP, independent auditors.

24      --    Power of Attorney (included as part of the signature page hereto)

ITEM 9. UNDERTAKINGS

      The Company undertakes:

      (1)   to file, during any period in which offers or sales are being made,
            a post-effective amendment to this registration statement:

            (i)   To include any prospectus required by Section 10(a)(3) of the
                  Securities Act of 1933;

            (ii)  To reflect in the prospectus any facts or events arising after
                  the effective date of the registration statement (or the most
                  recent post-effective amendment) which, individually or in the
                  aggregate, represent a fundamental change in the information
                  set forth in the registration statement;

            (iii) To include any material information about the plan of
                  distribution not already disclosed in the registration
                  statement or any material change to such information in the
                  registration statement;

            provided, however, that paragraphs (1)(i) and (1)(ii) do not apply
            if the registration statement is on Form S-3 or Form S-8 and the
            information required to be included in a post-effective amendment by
            those paragraphs is contained in periodic reports filed by the
            registrant pursuant to Section 13 or Section 15(d) of the Securities
            Exchange Act of 1934 that are incorporated by reference in the
            registration statement.

      (2)   that, for purposes of determining any liability under the Securities
            Act of 1933, each such post-effective amendment shall be a new
            registration statement relating to the securities offered, and the
            offering of such securities at that time will be viewed as the
            initial bona fide offering.

      (3)   to remove from registration by means of a post-effective amendment
            any of the securities being registered which remain unsold at the
            end of the offering.

      (4)   that, for purposes of determining any liability under the Securities
            Act of 1933, each filing of the registrant's annual report pursuant
            to Section 13(a) or Section 15(d) of the Securities Exchange Act of
            1934 (and, where applicable, each filing of an employee benefit
            plan's annual report pursuant to Section 15(d) of the Securities
            Exchange Act of 1934) that is incorporated by reference in the
            registration statement will be a new registration statement relating
            to the securities offered, and the offering of such securities at
            that time shall be viewed as the initial bona fide offering.

      Insofar as indemnification for liabilities arising under the Securities
Act of 1933 may be permitted to directors, officers and controlling persons of
the registrant under the foregoing provisions, or otherwise, the registrant has
been advised that in the opinion of the Securities and Exchange Commission such
indemnification is against public policy as expressed in the Act and is unenforceable. In the event that a claim for indemnification against such liabilities (other than the
payment by the registrant of expenses incurred or paid by a director, officer or
controlling person of the registrant in the successful defense of any action,
suit or proceeding) is asserted by such director, officer or controlling person
in connection with the securities being registered, the registrant will, unless
in the opinion of its counsel the matter has been settled by controlling
precedent, submit to a court of appropriate jurisdiction the question whether
such indemnification by it is against public policy as expressed in the Act and
will be governed by the final adjudication of such issue.

                                   SIGNATURES

      Under the requirements of the Securities Act of 1933, the Registrant has
reasonable grounds to believe that it meets all of the requirements for filing
on Form S-8 and has caused this Registration Statement to be signed on its
behalf by the authorized signer in The City of New York, State of New York, on
the 18th day of November, 2003.

                                      PFIZER INC

                                      By /s/ HENRY A. MCKINNELL
                                         --------------------------------------
                                         HENRY A. MCKINNELL
                                         Chairman of the Board , Chief Executive
                                         Officer and Director
                                         (Principal Executive Officer)

      Each person whose signature appears below hereby constitutes and appoints Margaret M. Foran,and Jeffrey B. Kindler and each of them, his or her true and lawful attorneys-in-factand agents, with full power of substitution and resubstitution, for him or her and in his or hername, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) and supplements to this Registration Statement, and to file the same, withall exhibits thereto, and other documents in connection therewith, with the Securities andExchange Commission, and hereby grants to such attorneys-in-fact and agents, full power andauthority to do and perform each and every act and thing requisite and necessary to be done, asfully with all intents and purposes as he or she might or could do in person, hereby ratifying andconfirming all that said attorneys-in-fact and agents, or either of them, or their or his or hersubstitutes, may lawfully do or cause to be done by virtue hereof.

      Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below by the following persons in the
capacities and on the dates indicated.

         SIGNATURE                       TITLE                  DATE
---------------------------    ------------------------     ---------------

/s/ HENRY A. MCKINNELL         Chairman of the Board,       November 18, 2003
---------------------------    Chief Executive Officer
(Henry A. McKinnell)           and Director (Principal
                               Executive Officer)

/s/ DAVID L. SHEDLARZ          Executive Vice President     November 18, 2003
---------------------------    and Chief Financial
(David L. Shedlarz)            Officer (Principal
                               Financial Officer)

/s/ LORETTA V. CANGIALOSI      Vice President -             November 18, 2003
---------------------------    Controller (Principal
(Loretta V. Cangialosi)        Accounting Officer)

/s/ MICHAEL S. BROWN           Director                     November 18, 2003
---------------------------
(Michael S. Brown)

/s/ M. ANTHONY BURNS           Director                     November 18, 2003
---------------------------
(M. Anthony Burns)

/s/ ROBERT N. BURT             Director                     November 18, 2003
---------------------------
 (Robert N. Burt)

/s/ W. DON CORNWELL            Director                     November 18, 2003
---------------------------
(W. Don Cornwell)

/s/ WILLIAM H. GRAY, III       Director                     November 18, 2003
---------------------------
(William H. Gray, III)

/s/ CONSTANCE J. HORNER        Director                     November 18, 2003
---------------------------
(Constance J. Horner)

/s/ WILLIAM R. HOWELL          Director                     November 18, 2003
---------------------------
(William R. Howell)

/s/ STANLEY O. IKENBERRY       Director                     November 18, 2003
---------------------------
(Stanley O. Ikenberry)

/s/ GEORGE A. LORCH            Director                     November 18, 2003
---------------------------
(George A. Lorch)

/s/ DANA G. MEAD               Director                     November 18, 2003
---------------------------
(Dana G. Mead)

/s/ FRANKLIN D. RAINES         Director                     November 18, 2003
---------------------------
(Franklin D. Raines)

/s/ RUTH J. SIMMONS            Director                     November 18, 2003
---------------------------
(Ruth J. Simmons)

/s/ WILLIAM C. STEERE, JR.     Director                     November 18, 2003
---------------------------
(William C. Steere, Jr.)

/s/ JEAN-PAUL VALLES           Director                     November 18, 2003
---------------------------
(Jean-Paul Valles)

THE PLAN

Pursuant to the requirements of the Securities Act of 1933, the Savings and
Investment Plan Committee has duly caused this registration statement to be
signed on its behalf by the undersigned, duly authorized in the City of New
York, State of New York, on November 18, 2003.

                                      Pfizer Canada Inc. Savings and Investment Plan

                                      By: /s/ DAVID L. SHEDLARZ
                                         --------------------------------------
                                          David L. Shedlarz
                                          Chair, Savings and Investment Plan
                                           Committee

                                  EXHIBIT INDEX

EXHIBIT

 5      --    Opinion and Consent of Margaret M. Foran, Esq., Vice President -
              Corporate Governance and Secretary.

23  (i) --    Consent of KPMG LLP, independent auditors.

23 (ii) --    Consent of PriceWaterhouseCoopers LLP, independent accountants.

23(iii) --    Consent of Deloitte & Touche LLP, independent auditors.

24      --    Power of Attorney (included as part of the signature page hereto)
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