| UNITED STATES  SECURITIES AND EXCHANGE COMMISSION  WASHINGTON, D.C. 20549  FORM 10-Q

   X     QUARTERLY  REPORT PURSUANT TO SECTION 13 OR 15(d)  OF THE SECURITIES EXCHANGE ACT OF 1934

**For the quarterly period ended October 2, 2005**

OR

TRANSITION REPORT  PURSUANT TO SECTION 13  OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition  period from________to_______

COMMISSION FILE  NUMBER 1-3619

----

**PFIZER INC.**(Exact name of registrant as specified in its charter)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |
|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| DELAWARE  (State of Incorporation)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    | 13-5315170  (I.R.S. Employer Identification No.) |
| 235 East 42nd Street, New York, New York   10017       (Address of principal executive offices)   (zip  code)  (212) 573-2323  (Registrant's telephone number)

Indicate by check mark whether the registrant (1) has filed  all reports required to be filed by Section 13 or 15(d) of the Securities  Exchange Act of 1934 during the preceding 12 months (or for such shorter  period that the registrant was required to file such reports) and (2) has  been subject to such filing requirements for the past 90 days.

YES    X             NO       

Indicate by check mark whether the registrant is an  accelerated filer (as defined in Rule 12b-2 of the Exchange Act).

YES    X             NO       

Indicate by check mark whether the registrant is a shell  company (as defined in Rule 12b-2 of the Exchange Act).

YES                    NO     X   

At November 4, 2005, 7,371,396,380 shares of the  issuer's voting common stock were outstanding. |

**FORM 10-Q**

**For the QuarterEndedOctober 2, 2005**

**Tableof Contents**

** **

| **PART I.  FINANCIAL  INFORMATION**                                                                                             | Page       |
|-------------------------------------------------------------------------------------------------------------------------------------------|------------|
|                                                                                                                                           |            |
| Item 1.                                                                                                                                   |            |
|                                                                                                                                 |            |
| Financial Statements:                                                                                                                     |            |
|                                                                                                                                 |            |
| Condensed  Consolidated Statements of Income for the three months and nine months ended October 2,  2005 and September 26, 2004 | 3          |
|                                                                                                                                 |            |
| Condensed  Consolidated Balance Sheets at October 2, 2005 and  December 31, 2004                                           | 4          |
|                                                                                                                                 |            |
| Condensed  Consolidated Statements of Cash Flows for the nine months ended October 2,  2005 and September 26, 2004              | 5          |
|                                                                                                                                 |            |
| Notes to  Condensed Consolidated Financial Statements                                                                                     | 6          |
|                                                                                                                                 |            |
| Review Report  of Independent Registered Public Accounting Firm                                                                           | 18         |
|                                                                                                                                 |            |
| Item 2.                                                                                                                                   |            |
|                                                                                                                                 |            |
| Management's  Discussion and Analysis of Financial Condition and Results of Operations                                                    | 19         |
|                                                                                                                                 |            |
| Item 4.                                                                                                                                   |            |
|                                                                                                                                 |            |
| Controls and  Procedures                                                                                                                  | 47         |
| **  **                                                                                                                          |            |
| **PART II.  OTHER  INFORMATION**                                                                                                | ** ** |
| **  **                                                                                                                          |            |
| Item 1.                                                                                                                                   |            |
|                                                                                                                                 |            |
| Legal  Proceedings                                                                                                                        | 47         |
|                                                                                                                                 |            |
| Item 2.                                                                                                                                   |            |
|                                                                                                                                 |            |
| Unregistered  Sales of Equity Securities and Use of Proceeds                                                                              | 50         |
|                                                                                                                                 |            |
| Item 6.                                                                                                                                   |            |
|                                                                                                                                 |            |
| Exhibits                                                                                                                                  | 50         |
|                                                                                                                                 |            |
| Signature                                                                                                                                 | 51         |
|                                                                                                                                 |            |
|                                                                                                                                 |            |

**PARTI - FINANCIAL INFORMATION**

Item 1. Financial Statements.

PFIZER INC ANDSUBSIDIARY COMPANIESCONDENSED CONSOLIDATED STATEMENTS OF INCOME(UNAUDITED)

|                                                                                                 |   | Three Months Ended             |   | Nine Months Ended                |
|-------------------------------------------------------------------------------------------------|---|--------------------------------|---|----------------------------------|
| (millions  of dollars, except per common share data)                                            |   | Oct. 2,   2005  |   | Sept. 26,   2004  |  | Oct. 2,   2005  |  | Sept. 26,   2004  |
|                                                                                       |   |                                |   |                                  |  |  |  |  |
| Revenues                                                                                        | $ | 12,189                    | $ | 12,831                      | $ | 37,705  | $ | 37,593  |
|                                                                                       |   |                                |   |                                  |  |  |  |  |
| Costs  and expenses:                                                                            |   |                                |   |                                  |  |  |  |  |
| Cost of sales(a)                                                                                |   | 1,908                     |   | 1,640                       |  | 6,180  |  | 5,185  |
| Selling, informational and administrative expenses(a)                                           |   | 3,931                     |   | 4,036                       |  | 12,242  |  | 12,227  |
| Research and development expenses(a)                                                            |   | 1,783                     |   | 1,888                       |  | 5,421  |  | 5,356  |
| Amortization of intangible assets(a)                                                            |   | 836                       |   | 843                         |  | 2,576  |  | 2,496  |
| Merger-related in-process research and development  charges                                     |   | 1,390                     |   | --                          |  | 1,652  |  | 955  |
| Restructuring charges and merger-related costs                                                  |   | 307                       |   | 190                         |  | 796  |  | 726  |
| Other (income)/deductions - net                                                       |   | (163)                          |   | 283                         |  | 669  |  | 140  |
|                                                                                       |   |                                |   |                                  |  |  |  |  |
| Income from continuing operations before provision  for taxes on income, and minority interests |   | 2,197                     |   | 3,951                       |  | 8,169  |  | 10,508  |
|                                                                                       |   |                                |   |                                  |  |  |  |  |
| Provision  for taxes on income                                                                  |   | 591                       |   | 650                         |  | 2,815  |  | 2,040  |
|                                                                                       |   |                                |   |                                  |  |  |  |  |
| Minority interests                                                                              |   | 4                         |   | 3                           |  | 9  |  | 7  |
|                                                                                       |   |                                |   |                                  |  |  |  |  |
| Income from continuing operations                                                               |   | 1,602                     |   | 3,298                       |  | 5,345  |  | 8,461  |
|                                                                                       |   |                                |   |                                  |  |  |  |  |
| Discontinued operations:                                                                        |   |                                |   |                                  |  |  |  |  |
| (Loss)/income from discontinued operations - net  of tax                              |   | (16)                           |   | (3)                              |  | (37) |  | 27  |
| Gains on sales of discontinued operations - net  of tax                               |   | 3                         |   | 46                          |  | 44  |  | 48  |
|                                                                                       |   |                                |   |                                  |  |  |  |  |
| Discontinued operations - net of tax                                                  |   | (13)                           |   | 43                          |  | 7  |  | 75  |
|                                                                                                 |   |                                |   |                                  |  |  |  |  |
| Net income                                                                                      | $ | 1,589                     | $ | 3,341                       | $ | 5,352  | $ | 8,536  |
|                                                                                       |   |                                |   |                                  |  |  |  |  |
| Earnings  per common share - Basic:                                                             |   |                                |   |                                  |  |  |  |  |
| Income from continuing operations                                                               | $ | 0.22                      | $ | 0.44                        | $ | 0.73  | $ | 1.12  |
| Discontinued operations - net of tax                                                  |   | --                        |   | 0.01                        |  | --  |  | 0.01  |
| Net income                                                                                      | $ | 0.22                      | $ | 0.45                        | $ | 0.73  | $ | 1.13  |
|                                                                                       |   |                                |   |                                  |  |  |  |  |
| Earnings  per common share - Diluted:                                                           |   |                                |   |                                  |  |  |  |  |
| Income from continuing operations                                                               | $ | 0.22                      | $ | 0.43                        | $ | 0.72  | $ | 1.11  |
| Discontinued operations - net of tax                                                  |   | --                        |   | 0.01                        |  | --  |  | 0.01  |
| Net income                                                                                      | $ | 0.22                      | $ | 0.44                        | $ | 0.72  | $ | 1.12  |
|                                                                                       |   |                                |   |                                  |  |  |  |  |
| Weighted-average shares used to calculate earnings per  common share:                           |   |                                |   |                                  |  |  |  |  |
| Basic                                                                                           |   | 7,333                     |   | 7,501                       |  | 7,372  |  | 7,554  |
|                                                                                       |   |                                |   |                                  |  |  |  |  |
| Diluted                                                                                         |   | 7,382                     |   | 7,569                       |  | 7,424  |  | 7,642  |
|                                                                                       |   |                                |   |                                  |  |  |  |  |
| Cash  dividends paid per common share                                                           | $ | 0.19                      | $ | 0.17                        | $ | 0.57  | $ | 0.51 |

  

| (a) | Includes  amortization of intangible assets, as disclosed in Note 11B, *Goodwill  and Other Intangible Assets: Other Intangible Assets.* |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------|

See accompanyingNotes to Condensed Consolidated Financial Statements.

PFIZER INC AND SUBSIDIARYCOMPANIESCONDENSED CONSOLIDATED BALANCE SHEETS(UNAUDITED)

| (millions  of dollars)                                                                                                |   | Oct. 2,   2005* |   | Dec. 31,   2004** |
|-----------------------------------------------------------------------------------------------------------------------|---|---------------------------|---|-----------------------------|
| ASSETS                                                                                                                |   |                           |   |                             |
| Current Assets                                                                                                        |   |                           |   |                             |
| Cash and cash  equivalents                                                                                            | $ | 959                  | $ | 1,808                  |
| Short-term  investments                                                                                               |   | 12,430               |   | 18,085                 |
| Accounts  receivable, less allowance for doubtful accounts: 2005 - $181;  2004 - $205             |   | 9,348                |   | 9,367                  |
| Short-term  loans                                                                                                     |   | 611                  |   | 653                    |
| Inventories                                                                                                           |   | 6,556                |   | 6,660                  |
| Prepaid  expenses and taxes                                                                                           |   | 2,724                |   | 2,939                  |
| Assets held for  sale                                                                                                 |   | 140                  |   | 182                    |
| Total current assets                                                                                                  |   | 32,768               |   | 39,694                 |
| Long-term  investments and loans                                                                                      |   | 2,784                |   | 3,873                  |
| Property, plant  and equipment, less accumulated depreciation:  2005 - $9,199; 2004 - $8,534      |   | 17,519               |   | 18,385                 |
| Goodwill                                                                                                              |   | 23,806               |   | 23,756                 |
| Identifiable  intangible assets, less accumulated amortization                                                        |   | 28,976               |   | 33,251                 |
| Other assets,  deferred taxes and deferred charges                                                                    |   | 4,490                |   | 4,725                  |
| Total assets                                                                                                          | $ | 110,343              | $ | 123,684                |
|                                                                                                             |   |                           |   |                             |
| LIABILITIES  AND SHAREHOLDERS' EQUITY                                                                                 |   |                           |   |                             |
| Current Liabilities                                                                                                   |   |                           |   |                             |
| Short-term  borrowings, including current portion of long-term debt:   2005 - $1,401; 2004 - $907 | $ | 6,729                | $ | 11,266                 |
| Accounts  payable                                                                                                     |   | 1,809                |   | 2,672                  |
| Dividends payable                                                                                                     |   | 3                    |   | 1,418                  |
| Income taxes  payable                                                                                                 |   | 4,226                |   | 1,963                  |
| Accrued  compensation and related items                                                                               |   | 1,636                |   | 1,939                  |
| Other current  liabilities                                                                                            |   | 5,990                |   | 7,136                  |
| Liabilities  held for sale                                                                                            |   | 2                    |   | 64                     |
| Total current liabilities                                                                                             |   | 20,395               |   | 26,458                 |
|                                                                                                   |   |                           |   |                             |
| Long-term debt                                                                                                        |   | 5,414                |   | 7,279                  |
| Pension benefit  obligations                                                                                          |   | 2,771                |   | 2,821                  |
| Postretirement  benefit obligations                                                                                   |   | 1,442                |   | 1,450                  |
| Deferred taxes  on income                                                                                             |   | 10,780               |   | 12,632                 |
| Other  noncurrent liabilities                                                                                         |   | 2,734                |   | 4,766                  |
| Total liabilities                                                                                                     |   | 43,536               |   | 55,406                 |
|                                                                                                             |   |                           |   |                             |
| Shareholders' Equity                                                                                                  |   |                           |   |                             |
| Preferred stock                                                                                                       |   | 175                  |   | 193                    |
| Common stock                                                                                                          |   | 439                  |   | 438                    |
| Additional  paid-in capital                                                                                           |   | 67,530               |   | 67,098                 |
| Employee  benefit trust, at fair value                                                                                |   | (970)                     |   | (1,229)                     |
| Treasury stock                                                                                                        |   | (39,385)                  |   | (35,992)                    |
| Retained  earnings                                                                                                    |   | 38,033               |   | 35,492                 |
| Accumulated  other comprehensive income                                                                               |   | 985                  |   | 2,278                  |
|                                                                                                             |   |                           |   |                             |
| Total shareholders' equity                                                                                            |   | 66,807               |   | 68,278                 |
| Total liabilities and shareholders'  equity                                                                           | $ | 110,343              | $ | 123,684                |

*    Unaudited.

**  Condensed from auditedfinancial statements.

See accompanying Notesto Condensed Consolidated Financial Statements.

PFIZER INC ANDSUBSIDIARY COMPANIESCONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS(UNAUDITED)

|                                                                                               |   | Nine Months Ended              |
|-----------------------------------------------------------------------------------------------|---|--------------------------------|
| (millions  of dollars)                                                                        |   | Oct. 2,   2005  |  | Sept. 26,   2004  |
|                                                                                     |   |                                |  |  |
| Operating Activities:                                                                         |   |                                |  |  |
| Net income                                                                                    | $ | 5,352                     | $ | 8,536  |
| Adjustments to reconcile net income to net cash  provided by continuing operating activities: |   |                                |  |  |
| Discontinued operations - net of tax                                                          |   | (7)                            |  | (75) |
| Depreciation and amortization                                                                 |   | 4,143                     |  | 3,782  |
| Merger-related in-process research and development  charges                                   |   | 1,652                     |  | 955  |
| Asset impairment charge and other costs associated  with the suspension of Bextra sales       |   | 1,216                     |  | --  |
| Deferred taxes                                                                                |   | (279)                          |  | (471) |
| Other                                                                                         |   | 193                       |  | 479  |
| Changes in assets and liabilities (net of businesses  acquired and divested)                  |   | (2,274)                        |  | (2,856) |
|                                                                                |   |                                |  |  |
| Net  cash provided by continuing operating activities                                         |   | 9,996                     |  | 10,350  |
|                                                                                |   |                                |  |  |
| Investing  Activities:                                                                        |   |                                |  |  |
| Purchases of property, plant and equipment                                                    |   | (1,493)                        |  | (1,526) |
| Purchases of short-term investments                                                           |   | (16,840)                       |  | (11,369) |
| Proceeds from redemptions of short-term investments                                           |   | 23,179                    |  | 6,427  |
| Purchases of long-term investments                                                            |   | (650)                          |  | (1,132) |
| Proceeds from sales of long-term investments                                                  |   | 655                       |  | 1,432  |
| Purchases of other assets                                                                     |   | (392)                          |  | (613) |
| Proceeds from sales of other assets                                                           |   | 6                         |  | 267  |
| Acquisitions, net of cash acquired                                                            |   | (2,104)                        |  | (1,443) |
| Proceeds from the sales of businesses and product  lines                                      |   | 108                       |  | 1,192  |
| Other investing activities                                                                    |   | 238                       |  | 32  |
|                                                                                |   |                                |  |  |
| Net  cash provided by/(used in) investing activities                                          |   | 2,707                     |  | (6,733) |
|                                                                                |   |                                |  |  |
| Financing  Activities:                                                                        |   |                                |  |  |
| Increase in short-term borrowings, net                                                        |   | 9                         |  | 2,094  |
| Principal payments on short-term borrowings                                                   |   | (5,274)                        |  | (238) |
| Proceeds from issuances of long-term debt                                                     |   | 5                         |  | 2,592  |
| Principal payments on long-term debt                                                          |   | (1,042)                        |  | (29) |
| Proceeds from common stock issuances                                                          |   | 45                        |  | 53  |
| Purchases of common stock                                                                     |   | (3,415)                        |  | (4,787) |
| Cash dividends paid                                                                           |   | (4,177)                        |  | (3,821) |
| Stock option transactions and other                                                           |   | 301                       |  | 856  |
|                                                                                |   |                                |  |  |
| Net cash used in financing activities                                                         |   | (13,548)                       |  | (3,280) |
| Effect of exchange-rate changes on cash and cash  equivalents                                 |   | (4)                            |  | 7  |
| Net (decrease)/increase in cash and cash equivalents                                          |   | (849)                          |  | 344  |
| Cash and cash equivalents at beginning of period                                              |   | 1,808                     |  | 1,520  |
|                                                                                     |   |                                |  |  |
| Cash and cash equivalents at end of period                                                    | $ | 959                       | $ | 1,864  |
|                                                                                     |   |                                |  |  |
| Supplemental Cash Flow Information:                                                           |   |                                |  |  |
| Cash paid during the period for:                                                              |   |                                |  |  |
| Income taxes                                                                                  | $ | 3,738                     | $ | 2,374  |
| Interest                                                                                      |   | 485                       |  | 312  |

** **

See accompanyingNotes to Condensed Consolidated Financial Statements.

PFIZERINC AND SUBSIDIARY COMPANIESNOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (UNAUDITED)

Note 1:  Basis of Presentation

*General*

We prepared the condensed consolidated financial statementsfollowing the requirements of the Securities and Exchange Commission (SEC) forinterim reporting. As permitted under those rules, certain footnotes or otherfinancial information that are normally required by accounting principlesgenerally accepted in the United States of America (GAAP) can be condensed oromitted. Balance sheet amounts and operating results for subsidiaries operatingoutside the U.S. are as of and for the three-month and nine-month periods endedAugust 28, 2005 and August 22, 2004. The fiscal first quarter and ninemonths of 2005 had three additional business days compared to the fiscal firstquarter and nine months of 2004. 

We made certain reclassifications to the 2004 condensedconsolidated financial statements to conform to the 2005 presentation.

Revenues, expenses, assets and liabilities can vary duringeach quarter of the year. Therefore, the results and trends in these interimfinancial statements may not be representative of those for the full year.

We are responsible for the unaudited financial statementsincluded in this document. The financial statements include all normal andrecurring adjustments that are considered necessary for the fair presentationof our financial position and operating results. 

The information included in this Quarterly Report onForm 10-Q should be read in conjunction with the consolidated financialstatements and accompanying notes included in Pfizer's Annual Report onForm 10-K for the year ended December 31, 2004.

*Share-Based Payments*

In accordance with Statement of Financial AccountingStandards (SFAS) No. 123, *Accounting for Stock-Based Compensation*, weelect to account for our stock-based compensation under Accounting PrinciplesBoard Opinion No. 25, *Accounting for Stock Issued to Employees*. Theexercise price of stock options granted equals the market price on the date ofgrant; as such, there is no recorded compensation expense related to grants ofstock options.

The weighted-average fair valueper stock option granted was $5.00 and $6.33 for the three months ended October 2,2005 and September 26, 2004, and $5.15 and $6.88 for the nine months endedOctober 2, 2005 and September 26, 2004. We estimated the fair values,as required under GAAP, using the Black-Scholes option-pricing model, modifiedfor dividends and using the assumptions below. Pro forma compensation expenserelated to stock options subject to accelerated vesting upon retirement isrecognized over the period of employment up to the vesting date of the grant.In the first quarter of 2005, we changed our method of estimating expecteddividend yield from historical patterns of dividend payments to a method thatreflects a constant dividend yield during the expected term of the option.

|                                       | Three Months Ended     |                        | Nine Months Ended |
|---------------------------------------|------------------------|------------------------|-------------------|
|                                       | Oct. 2,  2005     | Sept. 26,  2004   |                   | Oct. 2,  2005 | Sept. 26,  2004 |
|                                       |                        |                        |                   |  |  |
| Expected dividend yield               | 2.76%                  | 2.98%                  |                   | 2.90% | 2.90% |
| Risk-free interest rate               | 3.81%                  | 3.36%                  |                   | 3.96% | 3.32% |
| Expected stock price volatility       | 20.00%                 | 22.88%                 |                   | 21.93% | 22.15% |
| Expected term until exercise  (years) | 5.59    | 5.64    |                   | 5.75    | 5.75    |

The following table shows theeffect on results for the three-month and nine-month periods ended October 2,2005 and September 26, 2004 if we had applied the fair-value-basedrecognition provisions of SFAS 123 to measure stock-based compensationexpense for the option grants:

|                                                                                                             |   | Three  Months Ended            |   | Nine  Months Ended               |
|-------------------------------------------------------------------------------------------------------------|---|--------------------------------|---|----------------------------------|
| (millions  of dollars, except per common share data)                                                        |   | Oct. 2,   2005  |   | Sept. 26,   2004  |  | Oct. 2,   2005  |  | Sept. 26,   2004  |
|                                                                                                   |   |                                |   |                                  |  |  |  |  |
| Net income  available to common shareholders used in the calculation of basic earnings  per common share:   |   |                                |   |                                  |  |  |  |  |
| As reported  under GAAP*                                                                                    | $ | 1,588                     | $ | 3,340                       | $ | 5,348  | $ | 8,532  |
| Compensation  expense - net of tax                                                                          |   | (104)                          |   | (148)                            |  | (356) |  | (421) |
| Pro forma                                                                                                   | $ | 1,484                     | $ | 3,192                       | $ | 4,992  | $ | 8,111  |
|                                                                                              |   |                                |   |                                  |  |  |  |  |
| Basic earnings  per common share:                                                                           |   |                                |   |                                  |  |  |  |  |
| As reported  under GAAP*                                                                                    | $ | 0.22                      | $ | 0.45                        | $ | 0.73  | $ | 1.13  |
| Compensation  expense - net of tax                                                                          |   | (0.02)                         |   | (0.02)                           |  | (0.05) |  | (0.06) |
| Pro forma                                                                                                   | $ | 0.20                      | $ | 0.43                        | $ | 0.68  | $ | 1.07  |
|                                                                                                   |   |                                |   |                                  |  |  |  |  |
| Net income  available to common shareholders used in the calculation of diluted earnings  per common share: |   |                                |   |                                  |  |  |  |  |
| As reported  under GAAP*                                                                                    | $ | 1,588                     | $ | 3,340                       | $ | 5,349  | $ | 8,531  |
| Compensation  expense - net of tax                                                                          |   | (104)                          |   | (148)                            |  | (356) |  | (421) |
| Pro forma                                                                                                   | $ | 1,484                     | $ | 3,192                       | $ | 4,993  | $ | 8,110  |
|                                                                                                   |   |                                |   |                                  |  |  |  |  |
| Diluted  earnings per common share:                                                                         |   |                                |   |                                  |  |  |  |  |
| As reported  under GAAP*                                                                                    | $ | 0.22                      | $ | 0.44                        | $ | 0.72  | $ | 1.12  |
| Compensation  expense - net of tax                                                                          |   | (0.02)                         |   | (0.02)                           |  | (0.05) |  | (0.06) |
| Pro forma                                                                                                   | $ | 0.20                      | $ | 0.42                        | $ | 0.67  | $ | 1.06  |

  

| * | Includes  stock-based compensation expense, net of related tax benefits, of $81 million  for the nine months ended October 2, 2005 ($28 million for the  three months ended October 2, 2005) and $40 million for the nine  months ended September 26, 2004 (none for the three months ended  September 26, 2004). |
|---|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

Net income available to common shareholders used in thecalculation of basic earnings per common share represents net income reduced bypreferred stock dividends - net of tax. Net income available tocommon shareholders used in the calculation of diluted earnings per commonshare represents net income reduced by the incremental allocation of shares tothe Employee Stock Ownership Plans (ESOPs) acquired as part of the Pharmaciaacquisition.

Note 2:  Asset Impairment Charge and OtherCosts Associated with the Suspension of Bextra Sales

In the first nine months of 2005, we recorded chargestotaling $1.2 billion ($762 million, net of tax) in connection with thedecision to suspend sales and marketing of Bextra. This decision resulted froman April 7, 2005 request from the U.S. Food and Drug Administration (FDA),as part of its safety review of all COX-2 medicines.

The pre-tax charges included$1.1 billion related to the impairment of developed technology rightsassociated with Bextra and $7 million related to the write-off ofmachinery and equipment, both of which are included in *Other(income)/deductions - net.* In addition, in connection with thesuspension, we also recorded $56 million in write-offs of inventory andexit costs, included in *Cost of sales*; $8 million related to thecosts of administering the suspension of sales, included in *Selling,informational and administrative expenses;* and $212 million for anestimate of customer returns, primarily included against *Revenues.*Substantially all of these charges were recorded in the first quarter of 2005.

Note 3:  Income Taxes

*Income Tax Charge Associated with Repatriation Decision*

In the first nine months of 2005, we recorded an income taxcharge of $1.7 billion, included in *Provision for taxes on income*,in connection with our decision to repatriate about $36.7 billion offoreign earnings in accordance with the *American Jobs Creation Act of 2004*(the Jobs Act). In the first quarter of 2005, we recorded an initial estimatedincome tax charge of $2.2 billion based on the decision to repatriate $28.3 billionof foreign earnings; in the second quarter of 2005, we reduced our originalestimate of the tax charge by $863 million and revised the repatriation offoreign earnings to $28.1 billion, principally as a result of guidanceissued by the U.S. Treasury in May 2005. In the second quarter of 2005, we alsorecorded an additional tax charge of $373 million, primarily due to ourdecision to repatriate an additional $8.6 billion of foreign earnings.

As of October 2, 2005, we intend to continue to permanentlyreinvest the earnings of our international subsidiaries and, therefore, we havenot recorded a U.S. tax provision on the remaining amount of unremittedearnings.

*Tax Contingencies*

In the second quarter of 2005, we recorded a tax benefit of$586 million primarily related to the resolution of certain tax positions.We believe that the IRS audits of the Pfizer Inc. tax returns for the years1999-2001 and the Warner-Lambert Company tax returns for the years 1999 throughthe date of the merger with Pfizer (June 19, 2000) are substantiallycomplete. In connection with those audits, we are currently in the process ofappealing one matter related to the tax deductibility of a breakup fee paid byWarner-Lambert Company in 2000.

The IRS has commenced the audit of the Pfizer Inc. tax returnsfor the years 2002, 2003 and 2004. The 2005 tax year is also currently underaudit.

As previously disclosed, with respect to PharmaciaCorporation (formerly known as Monsanto Company), the IRS has completed andclosed its income tax return examinations and appeals through 1999 and hascommenced the audit of the tax returns for the years 2000 through the date ofmerger with Pfizer (April 16, 2003).

We periodically reassess the likelihood of assessmentsresulting from audits of federal, state and foreign income tax filings. Webelieve that our accruals for tax liabilities are adequate for all open years.

Note 4:  Adapting to Scale Initiative

We incurred the following costsin connection with our Adapting to Scale (AtS) initiative, which was announcedin the second quarter of 2005:

| (millions  of dollars)    |   | Three  Months  Ended  Oct. 2,  2005 |   | Nine  Months  Ended  Oct. 2,  2005 |
|---------------------------|---|------------------------------------------|---|-----------------------------------------|
|                 |   |                                          |   |                                         |
| Implementation  costs(a)  | $ | 104                                      | $ | 136                                     |
| Restructuring  charges(b) |   | 153                                      |   | 174                                     |
| Total AtS costs           | $ | 257                                      | $ | 310                                     |

   

| (a) | Included in *Cost of sales*  ($36 million),*Selling, informational and administrative expenses*  ($60 million), and *Research and development**expenses*  ($8 million) for the three months ended October 2, 2005, and  included in *Cost of sales* ($37 million), *Selling,  informational and administrative expenses*($81 million), and *Research  and development expenses* ($18 million) for the nine months ended  October 2, 2005. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| (b) | Included  in *Restructuring charges and merger-related costs.*                                                                                                                                                                                                                                                                                                                                                                                                                    |

In connection with the AtSinitiative, Pfizer management has performed a comprehensive review of ourprocesses, organizations, systems and decision-making procedures, in acompany-wide effort to improve performance and efficiency. We expect the costsassociated with this multi-year effort to continue through 2008 and to totalapproximately $4 billion to $5 billion, on a pre-tax basis. Theactions associated with the AtS initiative will include restructuring charges,such as asset impairments, exit costs and severance costs (including anyrelated impacts to our benefit plans, including settlements and curtailments)and associated implementation costs, such as accelerated depreciation charges,primarily associated with plant network optimization efforts, and expensesassociated with system and process standardization and the expansion of sharedservices. 

Through October 2, 2005,the restructuring charges primarily relate to employee termination costs at ourmanufacturing facilities in North America and the implementation costsprimarily relate to system and process standardization and to expansion ofshared services. 

The components of restructuringcosts associated with AtS follow:

| (millions  of dollars)      |   | Nine  Months  Ended  Oct. 2,  2005 |   | Utilization  Through  Oct. 2,  2005 |   |   | Accrual  at  Oct. 2,  2005 | (a) |
|-----------------------------|---|-----------------------------------------|---|------------------------------------------|--------|---|---------------------------------|-----|
|                             |   |                                         |   |                                          |        |   |                                 |     |
| Employee  termination costs | $ | 106                                     | $ | 49                                       |        | $ | 57                              |     |
| Asset  impairments          |   | 62                                      |   | 62                                       |        |   | --                              |     |
| Other                       |   | 6                                       |   | --                                       |        |   | 6                               |     |
|                   | $ | 174                                     | $ | 111                                      |        | $ | 63                              |     |

  

| (a) | Included  in *Other current liabilities.* |
|-----|-------------------------------------------|

   

During the three months ended October 2, 2005, we expensed $85 millionfor *Employee termination costs*, $62 million for *Assetimpairments* and $6 million in *Other*. Through October 2,2005, *Employee termination* costs represent the approved reduction of theworkforce by 922 employees, mainly in manufacturing, sales and research.We notified affected individuals and 903 employees were terminated as ofOctober 2, 2005. *Employee termination costs* are recorded asincurred and include accrued severance benefits, pension and postretirementbenefits. *Asset impairments* primarily include charges to write downintangible assets, and property, plant and equipment. *Other* primarilyincludes costs to exit certain activities.

Note 5:  Merger-RelatedCosts

We incurred the followingmerger-related costs primarily in connection with our acquisition of PharmaciaCorporation (Pharmacia), which was completed on April 16, 2003:

|                             |   | Three  Months Ended                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  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|                        |   |  
(a)

Included  in *Restructuring charges and merger-related costs*.

 
In connection with the acquisition of Pharmacia, Pfizermanagement approved plans to restructure and integrate the operations of bothlegacy Pfizer and legacy Pharmacia to combine operations, eliminate duplicativefacilities and reduce costs. Total merger-related expenditures expected to beincurred during 2003 through 2005 to achieve anticipated synergies are about$5.1 billion, on a pre-tax basis, with $5.0 billion incurred throughOctober 2, 2005. The restructuring of our operations as a result of ouracquisition of Pharmacia includes consulting, systems integrations, severance,costs of vacating duplicative facilities, contract termination and other exitcosts.

Through April 15, 2004, werecorded restructuring costs associated with employee terminations and exitingcertain activities of legacy Pharmacia as liabilities assumed in the purchasebusiness combination and recorded an increase to goodwill. Changes to previousestimates of restructuring costs included as part of the purchase allocation ofPharmacia are recorded as a reduction to goodwill or an expense to operations,as appropriate. Restructuring costs incurred for legacy Pfizer andrestructuring costs incurred after April 15, 2004 for legacy Pharmacia arecharged to the results of operations.

The components ofmerger-related restructuring costs associated with legacy Pfizer and legacyPharmacia follow:

(millions  of dollars)

Total

Utilization  Through  Oct. 2,  2005

(a)

Accrual  at  Oct. 2,  2005

(b)

  

Costs capitalized through April 15,  2004: 

Employee  termination costs

$

1,535

$

1,502

$

33

Other

624

517

107

$

2,159

$

2,019

$

140

Costs expensed:  

Employee  termination costs

$

590

$

508

$

82

Asset  impairments

421

421

--

Other

96

74

22

  

$

1,107

$

1,003

$

104

  

(a)

Includes  insignificant adjustments to original amounts established.

(b)

Included  in *Other current liabilities.*

During the three months ended October 2, 2005 and September26, 2004, we expensed $1 million and $53 million for *Employeetermination costs*, $53 million and $8 million for *Assetimpairments*, and $7 million and $16 million in *Other*.During the first nine months of 2005 and 2004, we expensed $73 million and$201 million for *Employee termination costs*, $131 million and$122 million for *Asset impairments*, and $22 million and $31 millionin *Other*.**Through October 2, 2005, *Employee terminationcosts*represent the approved reduction of the legacy Pfizer and legacy Pharmaciawork force by 17,086 employees, mainly in corporate, manufacturing,distribution, sales and research. We notified affected individuals and 16,385 employeeswere terminated as of October 2, 2005. *Employee termination costs* arerecorded as incurred and include accrued severance benefits and costsassociated with change-in-control provisions of certain Pharmacia employmentcontracts. *Asset impairments*primarily include charges to write downproperty, plant and equipment. *Other* primarily includes costs to exitcertain activities of legacy Pfizer and legacy Pharmacia.

Note 6: Acquisitions

On September 14, 2005, we completed the acquisition of allof the outstanding shares of Vicuron Pharmaceuticals, Inc. (Vicuron), a biopharmaceuticalcompany focused on the development of novel anti-infectives, for approximately$1.9 billion in cash (including transaction costs). Vicuron has twoproducts currently under New Drug Application (NDA) review by the FDA:anidulafungin for fungal infections and dalbavancin for Gram-positiveinfections. The allocation of the purchase price includes in-process researchand development of approximately $1.4 billion, which was expensed andincluded in *Merger-related in-process research and development charges*,and goodwill of $243 million, which has been allocated to our Human Healthsegment. Neither of these items is deductible for tax purposes.

On April 12, 2005, we completed the acquisition of Idun Pharmaceuticals,Inc. (Idun), a biopharmaceutical company focused on the discovery anddevelopment of therapies to control apoptosis, and on August 15, 2005, wecompleted the acquisition of all outstanding shares of Bioren Inc. (Bioren),which focuses on technology for optimizing antibodies. The aggregate cost ofthese and other smaller acquisitions was approximately $340 million forthe nine months ended October 2, 2005.

On February 10, 2004, we completed the acquisition of allthe outstanding shares of Esperion Therapeutics, Inc., (Esperion), abiopharmaceutical company, for $1.3 billion in cash (including transactioncosts). The allocation of the purchase price included in-process research anddevelopment of $920 million, which was expensed, and goodwill of $235 million,which was allocated to our Human Health segment. Neither of these items wasdeductible for tax purposes. The aggregate cost of other smaller acquisitionswas approximately $170 million for the nine months ended September 26,2004.

Note 7:  Dispositions

We evaluate our businesses and product lines periodically forstrategic fit within our operations. In the first quarter of 2004, we decidedto sell a number of businesses and product lines and we recorded the results ofthese operations in *Discontinued operations* for 2005 and 2004. As ofOctober 2, 2005, all of these discontinued operations have been sold. Theimpact of these divested businesses and product lines was not material to theconsolidated operating results of Pfizer Inc in the periods presented.

*Assets held for sale*and*Liabilities held for sal*eon the balance sheet at October 2, 2005, relate primarily to assets inEurope that we intend to sell but that are not related to*Discontinued operations*.

Note 8:  Comprehensive Income/(Expense)

The components of comprehensiveincome/(expense) follow:

Three  Months Ended

Nine  Months Ended

(millions  of dollars)

Oct. 2,   2005 

Sept. 26,   2004 

Oct. 2,   2005 

Sept. 26,   2004 

  

Net income

$

1,589 

$

3,341 

$

5,352 

$

8,536 

Other comprehensive  income/(expense):

Net unrealized gain/(loss)  on available-for-sale securities arising during the period - net of  tax

7 

(30)

(98)

153 

Currency  translation adjustment and other

(183)

689 

(1,195)

451 

Total other  comprehensive income/(expense)

(176)

659 

(1,293)

604 

Total comprehensive income/(expense)

$

1,413 

$

4,000 

$

4,059 

$

9,140 

Note 9:  Financial Instruments

*Derivative FinancialInstruments and Hedging Activities*

During the first nine months of2005, we entered into the following incremental or new derivative and hedgingactivities:

Financial  Instrument

Hedge Type

Hedged  or Offset Item

Notional Amount  (millions of dollars)

Maturity Date
                           
Swaps

Net  investment

Euro net investments

             $1,255

Sept.-Oct. 2006

Forward-exchange contracts

--

Short-term foreign currency assets and liabilities(a)  

                  674

Through 2006

Forward-exchange contracts

Cash  flow

Euro available-for-sale investments

                  493

Through 2006

Forward-exchange contracts

Cash  flow

Danish krone available-for-sale investments

                  172

Through 2006

 

(a)

Forward-exchange  contracts used to offset short-term foreign currency assets and liabilities  were primarily for intercompany transactions in euros, Australian dollars,  U.K. pounds, Swedish krona and Canadian dollars for the nine months ended  October 2, 2005.

These foreign exchangederivatives serve to protect net income and net investments against the impactof the translation into U.S. dollars of certain foreign exchange denominatedtransactions. There was no material ineffectiveness in any hedging relationshipreported in earnings in the first nine months of 2005.

*Long-Term Debt*

In July 2005, we decided to exercise Pfizer's option tocall, at par-value plus accrued interest, $1 billion of senior unsecuredfloating-rate notes, which were included in *Long-term debt* at December31, 2004. Notice to call was given to the Trustees and the notes were redeemedin September 2005.

Note 10:  Inventories

The components of inventoriesfollow:

(millions of dollars)

Oct. 2,  2005

Dec. 31,  2004

   

Finished goods

$

2,600

$

2,643

Work-in-process

2,714

2,703

Raw materials  and supplies

1,242

1,314

Total  inventories

$

6,556

$

6,660

A reclassification was made in 2004 from *Finished goods*to*Work-in-process*to better reflect the stage of completion.

Note 11:  Goodwill and Other Intangible Assets

A.  Goodwill

The changes in the carryingamount of goodwill by segment for the nine months ended October 2, 2005follow:

(millions  of dollars)

Human  Health

Consumer  Healthcare

Animal   Health 

Other

Total

  

Balance,  December 31, 2004

$

20,966

$

2,701

$

79 

$

10

$

23,756

Other(a)

13

62

(25)

--

50

Balance, October 2,  2005

$

20,979

$

2,763

$

54 

$

10

$

23,806

  

(a)

Primarily  the acquisition of Vicuron, the impact of foreign exchange and reductions to  goodwill as a result of adjusting certain purchase accounting liabilities.

B.  Other Intangible Assets

The components of identifiableintangible assets, primarily included in our Human Health segment, follow:

Oct. 2,  2005

Dec. 31,  2004

(millions  of dollars)

Gross   Carrying   Amount 

Accumulated   Amortization 

Gross   Carrying   Amount 

Accumulated   Amortization 

  

Finite-lived  intangible assets:

Developed  technology rights

$

31,102 

$

(8,070)

$

33,137

$

(5,967)

Brands

1,057 

(48)

1,037

(14)

License  agreements

165 

(28)

158

(17)

Trademarks

157 

(92)

134

(90)

Other(a)

436 

(205)

390

(186)

Total amortized  finite-lived intangible assets

32,917 

(8,443)

34,856

(6,274)

Indefinite-lived  intangible assets:

Brands

3,898 

-- 

4,012

-- 

License  agreements

316 

-- 

356

-- 

Trademarks

227 

-- 

235

-- 

Other(b)

61 

-- 

66

-- 

Total indefinite-lived  intangible assets

4,502 

-- 

4,669

-- 

Total  identifiable intangible assets

$

37,419 

$

(8,443)

$

39,525

$

(6,274)

  

Total  identifiable intangible assets, less accumulated amortization

$  

28,976

$  

33,251

  

(a)

Includes  patents, non-compete agreements, customer contracts and other intangible  assets.

(b)

Includes  pension-related intangible assets.

In the first nine months of 2005, we recorded an impairmentcharge of $1.1 billion related to the developed technology rights forBextra, a selective COX-2 inhibitor (see Note 2, *Asset Impairment Charge andOther Costs Associated with the Suspension of Bextra Sales*) which wasincluded in *Other (income)/deductions - net*.

Amortization expense related to acquired intangible assetsthat contribute to our ability to sell, manufacture, research, market anddistribute our products are included in *Amortization of intangible assets*as they benefit multiple business functions. Amortization expense related toacquired intangible assets that are associated with a single function areincluded in *Cost of sales, Selling, informational and administrative**expenses*or *Research and development expenses*, as appropriate. Totalamortization expense for finite-lived intangible assets was $859 millionfor the three months ended October 2, 2005 and September 26, 2004 and$2.6 billion and $2.5 billion for the nine months ended October 2,2005 and September 26, 2004.

The annual amortization expense expected for the fiscal years2005 through 2010 is $3.5 billion in 2005, $3.4 billion in 2006 and2007, $2.7 billion in 2008 and $2.5 billion in 2009 and 2010.

Note 12:  Benefit Plans

The components of net periodicbenefit cost of the U.S. and international pension plans and the postretirementplans for the three months ended October 2, 2005 and September 26,2004 follow:

Pension Plans

U.S. Qualified

U.S. Supplemental  (Non-Qualified)

International

Postretirement Plans

(millions  of dollars)

2005 

2004 

2005

2004

2005 

2004 

2005 

2004 

   

Service cost

$

80 

$

71 

$

9

$

8 

$

71 

$

67 

$

10 

$

7 

Interest cost

104 

98 

15

15 

76 

71 

28 

18 

Expected return on plan assets

(148)

(143)

--

-- 

(77)

(74)

(6)

(4)

Amortization of:

Prior service costs/(gains)

4 

5 

--

-- 

(1)

3 

1 

-- 

Net transition obligation

-- 

-- 

--

-- 

1 

-- 

-- 

-- 

Actuarial losses

26 

25 

10

9 

23 

15 

4 

-- 

Curtailments and settlements - net

3 

-- 

--

-- 

1 

18 

-- 

-- 

Special termination benefits

1 

-- 

--

-- 

1 

-- 

1 

-- 

Net periodic benefit costs

$

70 

$

56 

$

34

$

32 

$

95 

$

100 

$

38 

$

21 

The components of net periodicbenefit cost of the U.S. and international pension plans and the postretirementplans for the nine months ended October 2, 2005 and September 26,2004 follow:

Pension Plans

U.S. Qualified

U.S. Supplemental  (Non-Qualified)

International

Postretirement Plans

(millions  of dollars)

2005 

2004 

2005

2004 

2005 

2004 

2005 

2004 

   

Service cost

$

239 

$

215 

$

28

$

25 

$

224 

$

197 

$

29 

$

27 

Interest cost

310 

293 

44

44 

234 

214 

84 

80 

Expected return on plan assets

(445)

(429)

--

-- 

(238)

(215)

(17)

(15)

Amortization of:

Prior service costs/(gains)

11 

13 

1

1 

(2)

7 

1 

1 

Net transition obligation

-- 

-- 

--

-- 

2 

1 

-- 

-- 

Actuarial losses

77 

74 

29

27 

71 

42 

14 

12 

Curtailments and settlements - net

3 

-- 

--

-- 

11 

(1)

-- 

-- 

Special termination benefits

1 

-- 

--

-- 

11 

-- 

1 

-- 

Net periodic benefit costs

$

196 

$

166 

$

102

$

97 

$

313 

$

245 

$

112 

$

105 

For the first nine months of2005, we contributed from the Company's general assets $52 million to ourU.S. qualified pension plans, $301 million to our international pensionplans, $124 million to our U.S. supplemental (non-qualified) pension plansand $123 million to our postretirement plans. As of October 2, 2005,we expect to contribute, from the Company's general assets during 2005, a total(inclusive of amounts contributed during the first nine months of 2005) of $53 millionto our U.S. qualified pension plans, $396 million to our internationalpension plans, $137 million to our U.S. supplemental (non-qualified)pension plans and $166 million to our postretirement plans. Thecontributions from the Company's general assets include direct employer benefitpayments.

Note 13:  Earnings Per Common Share

Basic and diluted earnings percommon share (EPS) were computed using the following common share data:

Three  Months Ended

Nine  Months Ended

(millions)

Oct. 2,   2005 

Sept. 26,  2004

Oct. 2,  2005

Sept. 26,  2004

  

EPS Numerator -  Basic:

Income from  continuing operations

$

1,602 

$

3,298

$

5,345

$

8,461

Less:  Preferred  stock dividends - net of tax

1 

1

4

4

Income  available to common shareholders from continuing operations

1,601 

3,297

5,341

8,457

Discontinued  operations - net of tax

(13)

43

7

75

Net income  available to common shareholders

$

1,588 

$

3,340

$

5,348

$

8,532

  

EPS Denominator  - Basic:

Weighted-average  number of common shares outstanding

7,333 

7,501

7,372

7,554

  

EPS Numerator -  Diluted:

Income from  continuing operations

$

1,602 

$

3,298

$

5,345

$

8,461

Less:  ESOP  contribution - net of tax

1 

1

3

5

Income  available to common shareholders from continuing operations 

1,601 

3,297

5,342

8,456

Discontinued  operations - net of tax

(13)

43

7

75

Net income  available to common shareholders

$

1,588 

$

3,340

$

5,349

$

8,531

  

EPS Denominator  - Diluted:

Weighted-average  number of common shares outstanding

7,333 

7,501

7,372

7,554

Common share  equivalents: stock options, restricted stock units, stock issuable under  employee compensation plans and convertible preferred stock

49 

68

52

88

Weighted-average  number of common shares outstanding and common share equivalents

7,382 

7,569

7,424

7,642

Outstanding stock options, representing about 563 millionand 513 million shares of common stock during the three-month and nine-monthperiods ended October 2, 2005, and about 391 million and 319 millionshares of common stock during the three-month and nine-month periods ended September 26,2004, had exercise prices greater than the average market price of our commonstock. These options were excluded from the computation of diluted EPS for theseperiods because their inclusion would have had an antidilutive effect.

Also, in the diluted computation, income from continuingoperations and net income are reduced by the incremental contribution to theESOPs, which were acquired as part of our Pharmacia acquisition. Thiscontribution is the after-tax difference between the income that the ESOPs wouldhave received in preferred stock dividends and the dividend on the commonshares assumed to have been outstanding.

Note 14:  Segment Information

We operate in the followingbusiness segments:

*Human Health*

  

•

The Human  Health segment, which represents our pharmaceutical business, includes  treatments for cardiovascular and metabolic diseases, central nervous system  disorders, arthritis and pain, infectious and respiratory diseases,  urogenital conditions, cancer, eye disease, endocrine disorders and allergies.

   

*Consumer  Healthcare*

  

•

The Consumer Healthcare  segment includes self-medications for oral care, upper respiratory health,  tobacco dependence, gastrointestinal health, skin care, eye care and hair  growth.

   

*Animal  Health*

  

•

The Animal Health  segment includes treatments for diseases in livestock and companion animals.

Segment profit/(loss) is measured based on income fromcontinuing operations before provision for taxes on income, minority interestsand certain costs, such as significant impacts of purchase accounting foracquisitions and restructuring charges and merger-related costs. Thismethodology is utilized by management to evaluate each business. Certainincome/(expense) items that are excluded from the operating segments'profit/(loss) are considered corporate items and therefore are included in *Corporate/Other*.

Revenues and profit/(loss) bysegment for the three months and nine months ended October 2, 2005, and September 26,2004, follow:

Three  Months Ended

Nine  Months Ended

(millions  of dollars)

Oct. 2,   2005 

Sept. 26,   2004 

Oct. 2,   2005 

Sept. 26,   2004 

  

Revenues:

Human Health

$

10,552 

$

11,288 

$

32,629 

$

33,033 

Consumer  Healthcare

921 

851 

2,835 

2,524 

Animal Health

503 

475 

1,576 

1,387 

Corporate/Other(a)

213 

217 

665 

649 

Total revenues

$

12,189 

$

12,831 

$

37,705 

$

37,593 

   

Profit/(loss)

Human Health

$

4,876 

$

5,332 

$

14,811 

$

15,269 

Consumer  Healthcare

169 

170 

457 

483 

Animal Health

85 

82 

288 

237 

Corporate/Other(a)

(2,933)

(b)

(1,633)

(c)

(7,387)

(b)

(5,481)

(c)

Total profit/(loss)

$

2,197 

$

3,951 

$

8,169 

$

10,508 

  

(a)

Includes  certain income/(expense) items that are excluded from the operating segment  profit/(loss) that are considered corporate items and, therefore, are included  in *Corporate/Other*. These items include interest income/(expense),  corporate expenses (e.g., corporate administration costs), other  income/(expense) items, certain equity-based compensation expenses not  allocated to the business segments, significant impacts of purchase  accounting for acquisitions, certain milestone payments, Adapting to Scale  restructuring charges and implementation costs, merger-related costs and  intangible asset impairments.

  

(b)

For  the three months and nine months ended October 2, 2005, *Corporate/Other*  includes (i) significant impacts of purchase accounting for acquisitions of  $2.2 billion and $4.1 billion, including acquired in-process  research and development, incremental intangible asset amortization and other  charges, (ii) merger-related costs of $154 million and $622 million,  (iii) restructuring charges and implementation costs associated with the Adapting  to Scale initiative of $257 million and $310 million and (iv) costs  associated with the suspension of Bextra's sales and marketing of $3 million  and $1.2 billion.

  

(c)

For  the three months and nine months ended September 26, 2004, *Corporate/Other*  includes (i) significant impacts of purchase accounting for acquisitions of  $827 million and $3.4 billion, including acquired in-process  research and development, incremental intangible asset amortization and other  charges, (ii) merger-related costs of $190 million and $726 million  and (iii) the operating results of a divested legacy Pharmacia research  facility of $64 million in the first nine months of 2004 and a  litigation-related charge of $369 million in the third quarter of 2004.

Revenues for each group ofsimilar products follow:

Three  Months Ended

Nine  Months Ended

(millions  of dollars)

Oct. 2,  2005

Sept. 26,  2004

%  Change

Oct. 2,  2005

Sept. 26,  2004

%  Change

**  **

**HUMAN HEALTH**

Cardiovascular and metabolic diseases

$

4,467

$

4,251

5%

$

13,664

$

12,335

11%

Central nervous system disorders

1,590

2,090

(24)  

4,718

6,072

(22)  

Arthritis and pain

545

1,274

(57)  

1,729

3,596

(52)  

Infectious and respiratory diseases

1,073

1,015

6   

3,657

3,375

8   

Urology

629

647

(3)  

1,958

1,865

5   

Oncology

507

368

38   

1,499

1,049

43   

Ophthalmology

338

304

11   

1,011

874

16   

Endocrine disorders

262

226

16   

783

668

17   

All other

874

919

(5)  

2,853

2,723

5   

Alliance revenue

267

194

38   

757

476

59   

Total Human Health

10,552

11,288

(7)  

32,629

33,033

(1)  

**CONSUMER HEALTHCARE**

921

851

8   

2,835

2,524

12   

**ANIMAL HEALTH**

503

475

6   

1,576

1,387

14   

**OTHER**

213

217

(2)  

665

649

2   

Total revenues

$

12,189

$

12,831

(5)  

$

37,705

$

37,593

--   

 

REVIEW REPORT OFINDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

To the Shareholders and Board of Directors of Pfizer Inc:

We have reviewed the condensed consolidated balance sheet ofPfizer Inc and Subsidiary Companies as of October 2, 2005, the relatedcondensed consolidated statements of income for the three-month and nine-monthperiods ended October 2, 2005 and September 26, 2004, and the relatedcondensed consolidated statements of cash flows for the nine-month periods endedOctober 2, 2005 and September 26, 2004. These condensed consolidatedfinancial statements are the responsibility of the Company's management. 

We conducted our reviews in accordance with the standards ofthe Public Company Accounting Oversight Board (United States). A review ofinterim financial information consists principally of applying analyticalprocedures and making inquiries of persons responsible for financial andaccounting matters. It is substantially less in scope than an audit conductedin accordance with the standards of the Public Company Accounting OversightBoard (United States), the objective of which is the expression of an opinionregarding the financial statements taken as a whole. Accordingly, we do notexpress such an opinion.

Based on our reviews, we are not aware of any materialmodifications that should be made to the condensed consolidated financialstatements referred to above for them to be in conformity with U.S. generallyaccepted accounting principles.

We have previously audited, in accordance with standards ofthe Public Company Accounting Oversight Board (United States), the consolidatedbalance sheet of Pfizer Inc and Subsidiary Companies as of December 31,2004, and the related consolidated statements of income, shareholders' equity,and cash flows for the year then ended (not presented herein); and in ourreport dated February 24, 2005, we expressed an unqualified opinion onthose consolidated financial statements. In our opinion, the information setforth in the accompanying condensed consolidated balance sheet as of December 31,2004, is fairly stated, in all material respects, in relation to theconsolidated balance sheet from which it has been derived.

KPMG LLP

New York, New YorkNovember 9, 2005

Item 2.  Management'sDiscussion and Analysis of Financial Condition and Results of Operations.

Components of the CondensedConsolidated Statement of Income follow:

Third Quarter

First Nine Months

(millions  of dollars, except per common share data)

2005 

2004 

% Change 

2005 

2004 

% Change 

    

Revenues

$

12,189 

$

12,831 

(5)

$

37,705 

$

37,593 

-- 

  

Cost of sales

1,908 

1,640 

16 

6,180 

5,185 

19 

% of revenues

15.7 

%

12.8 

%

16.4 

%

13.8 

%

  

Selling, informational and administrative expenses

3,931 

4,036 

(3)

12,242 

12,227 

-- 

% of revenues

32.3 

%

31.5 

%

32.5 

%

32.5 

%

  

Research and development expenses

1,783 

1,888 

(6)

5,421 

5,356 

1 

% of revenues

14.6 

%

14.7 

%

14.4 

%

14.2 

%

  

Amortization of intangible assets

836 

843 

(1)

2,576 

2,496 

3 

% of revenues

6.9 

%

6.6 

%

6.8 

%

6.6 

%

  

Merger-related in-process research and development  charges

1,390 

-- 

* 

1,652 

955 

73 

% of revenues

11.4 

%

-- 

4.4 

%

2.5 

%

  

Restructuring charges and merger-related costs

307 

190 

62 

796 

726 

10 

% of revenues

2.5 

%

1.5 

%

2.1 

%

1.9 

%

  

Other (income)/deductions - net

(163)

283 

* 

669 

140 

378 

   

Income from continuing operations before provision  for taxes on income and minority interests 

2,197 

3,951 

(44)

8,169 

10,508 

(22)

% of revenues

18.0 

%

30.8 

%

21.7 

%

28.0 

%

  

Provision for taxes on income

591 

650 

(9)

2,815 

2,040 

38 

  

Effective tax rate

26.9 

%

16.5 

%

34.4 

%

19.4 

%

  

53 

Minority interests

4 

3 

9 

7 

33 

  

Income from continuing operations  

1,602 

3,298 

(51)

5,345 

8,461 

(37)

% of revenues

13.1 

%

25.7 

%

14.2 

%

22.5 

%

  

Discontinued operations - net of tax

(13)

43 

* 

7 

75 

(91)

  

Net income

$

1,589 

$

3,341 

(52)

$

5,352 

$

8,536 

(37)

% of revenues

13.0 

%

26.0 

%

14.2 

%

22.7 

%

  

Earnings per common share - Basic:

Income from continuing operations

$

0.22 

$

0.44 

(50)

$

0.73 

$

1.12 

(35)

Discontinued operations - net of tax

-- 

0.01 

* 

-- 

0.01 

* 

Net income

$

0.22 

$

0.45 

(51)

$

0.73 

$

1.13 

(35)

  

Earnings per common share - Diluted:

Income from continuing operations

$

0.22 

$

0.43 

(49)

$

0.72 

$

1.11 

(35)

Discontinued operations - net of tax

-- 

0.01 

* 

-- 

0.01 

* 

Net income

$

0.22 

$

0.44 

(50)

$

0.72 

$

1.12 

(36)

  

Cash dividends paid per common share

$

0.19 

$

0.17 

$

0.57 

$

0.51 

  

*  Calculation not meaningful

OVERVIEW OF OUR CONSOLIDATED OPERATING RESULTS

*Our Business*

We are a research-based, globalpharmaceutical company that discovers, develops, manufactures and marketsleading prescription medicines for humans and animals, as well as many of theworld's best known consumer healthcare products. Our longstanding valueproposition has been to prove that our medicines cure or treat disease,including symptoms and suffering, and this remains our core mission. We haveexpanded our value proposition to also show that our medicines not only cancure or treat disease, but also can markedly improve health systems by reducingoverall healthcare costs, improving societies' economic well-being andincreasing effective prevention and treatment of disease. We generate revenuethrough the sale of our products, as well as through alliance agreements bycopromoting products discovered by other companies.

*Acquisitions*

On September 14, 2005, we completed the acquisition of allof the outstanding shares of Vicuron Pharmaceuticals, Inc. (Vicuron), abiopharmaceutical company focused on the development of novel anti-infectives,for approximately $1.9 billion in cash (including transaction costs).Vicuron has two products currently under New Drug Application (NDA) review bythe U.S. Food and Drug Administration (FDA): anidulafungin for fungalinfections and dalbavancin for Gram-positive infections. The allocation of thepurchase price includes in-process research and development of approximately$1.4 billion, which was expensed and included in *Merger-relatedin-process research and development charges*, and goodwill of $243 million,which has been allocated to our Human Health segment. Neither of these items isdeductible for tax purposes.

On April 12, 2005, we completed the acquisition of IdunPharmaceuticals, Inc. (Idun), a biopharmaceutical company focused on thediscovery and development of therapies to control apoptosis, and on August 15,2005, we completed the acquisition of all outstanding shares of Bioren Inc.(Bioren), which focuses on technology for optimizing antibodies. The aggregatecost of these and other smaller acquisitions was approximately $340 millionfor the nine months ended October 2, 2005.

On February 10, 2004, we completed the acquisition of allthe outstanding shares of Esperion Therapeutics, Inc., (Esperion), abiopharmaceutical company, for $1.3 billion in cash (including transactioncosts). The allocation of the purchase price included in-process research anddevelopment of $920 million, which was expensed, and goodwill of $235 million,which was allocated to our Human Health segment. Neither of these items wasdeductible for tax purposes. The aggregate cost of other smaller acquisitionswas approximately $170 million for the nine months endedSeptember 26, 2004.

*Our Operating Environment*

We continue to face a dynamically challenging and changingenvironment in our pharmaceutical business, including the loss of exclusivityof major products, continuing pressures on selective COX-2 inhibitor products,the increasing regulatory scrutiny of drug safety, the adoption of new direct-to-consumeradvertising guidelines and lower prescription growth rates and increasedcompetition in certain therapeutic areas. 

Our performance in 2005 has been,and will continue to be, impacted by loss of U.S. exclusivity of four majorproducts -- Diflucan, Neurontin, and Accupril/Accuretic during 2004 andZithromax in November 2005. In addition, we face the loss of U.S. exclusivityfor Zoloft during 2006 and Norvasc and Zyrtec during 2007. These seven productsrepresented 33% of our Human Health revenues and 29% of our total revenues forthe year ended December 31, 2004. Revenues in 2005 have also been, and maycontinue to be, impacted by publicity and regulatory actions regarding selectiveCOX-2 inhibitor products (see further discussion in the section "SelectedProduct Descriptions"). Our total revenues decreased 5% in the third quarterof 2005 and were flat in the first nine months of 2005 as compared to the sameperiods in 2004.

Partially offsetting theseimpacts in the first nine months of 2005 was the solidperformance in the aggregate of the balance ofour broad portfolio of patent-protected medicines. Our portfolio of medicinesincludes five of the world's 25 best-selling medicines, with 11 medicines thatlead their therapeutic areas. Our results reflect two underlying forces.First, Pfizer markets the broadest array of in-line and recently launchedproducts in the industry; and second, Pfizer is a business going through aprocess of reinventing itself. We are addressing the loss of exclusivity of anumber of products by advancing a number of internally developed, in-licensed andcopromoted product candidates.

We believe we have important competitive advantages thatwill serve us well and distinguish us from others in our industry. Our productportfolio and pipeline demonstrate the benefits of Pfizer's scale and our skillat leveraging the opportunities it provides us. Scale also enhances our statusas 'partner of choice' with other companies who have promising productcandidates and technologies, as well as giving us influence as a globalpurchaser of goods and services. We continueto build on and enhance our Research & Development capabilities throughacquisitions and collaborations; and through targeted acquisitions, licensingopportunities and internal development, we are augmenting our commercialportfolio. We have also made progress with our Adapting to Scale initiative,which is a focused, company-wide effort to leverage our scale and strength morerobustly and increase our productivity. (See further discussion in the section "*Adaptingto Scale Productivity Initiative and Merger-Related Synergies*.*")*

We believe that our strategic andoperating flexibility allows us to marshal andfocus resources when and where they are needed, to change with a changingenvironment and to recognize and seize emerging opportunities.

*Adaptingto Scale Productivity Initiative and Merger-Related Synergies*

During the second and thirdquarters of 2005, we made progress with our multi-year productivity initiative,called Adapting to Scale (AtS), to increase efficiency and streamline decisionmaking across the Company. This initiative, first announced in April 2005,follows the integration of Warner-Lambert and Pharmacia Corporation(Pharmacia), which resulted in the tripling of Pfizer's revenues over the pastfive years. The integration of those two companies will result in a combinedexpense reduction of approximately $6 billion, inclusive of$4.2 billion in Pharmacia-related synergies that will be achieved thisyear. The new AtS productivity initiative is expected to yield $4 billionin cost savings on an annual basis by 2008, based on a top-to-bottom businessreview completed during the first half of 2005.

During 2005, we anticipate thatcost savings from our AtS initiative will exceed $600 million, greaterthan previously forecasted, mainly attributable to the Human Health business.We expect that annual cost savings will accelerate over the following threeyears, with about $2 billion in savings targeted for 2006, about $3.5 billionin 2007 and about $4 billion upon completion in 2008. These savings areexpected to be realized in procurement, operating expenses and facilities,among other sources. We plan to use the cost savings we generate, in part, to fundkey investments, including new product launches and the development of the manypromising new medicines in our pipeline. The Company expects that the aggregatecost of implementing this initiative through 2008 will be approximately $4 billionto $5 billion on a pre-tax basis.

While some projects are alreadyunderway, during the fourth quarter of 2005, we will continue to accelerate theimplementation of changes, including:

•

Reorganizing Pfizer Global Research  & Development (PGRD) to increase efficiency and effectiveness in bringing  new therapies to patients-in-need while reducing the cost of research and  development. PGRD is being reorganized into eleven therapeutic categories --  cardiovascular, metabolic, and endocrine; central nervous system;  inflammation; allergy and respiratory; infectious diseases; pain;  gastrointestinal and hepatitis; oncology; urology and sexual health;  ophthalmology; and dermatology. Each therapeutic area will have three team  leaders -- a research leader for compounds not yet in human testing, a  development leader for compounds in human testing not yet marketed, and a  commercial leader for marketed compounds. Discovery Research will retain its  existing structure of six drug-candidate-producing sites. Development will  move toward single sites for most therapeutic areas.

  

•

Continuing our optimization of  Pfizer Global Manufacturing's plant network, which began with the acquisition  of Pharmacia, to ensure that the Company's manufacturing facilities are  aligned with current and future product needs. Since December 2004, Pfizer  has announced the divestiture of facilities in Holland, MI; Angers and  Val-de-Reuil, France; Morpeth, U.K.; and Stockholm, Sweden, as well as other,  smaller facilities. In the last few months, Pfizer announced the cessation of  operations in Corby, U.K. and Orangeville, Canada; a significant downsizing  in Lincoln, NE; and that plants in Lititz, PA, Groton, CT, and Inchera and  Little Island, Ireland would be restructured. We also determined that the  Augusta, GA plant will be closed. The restructuring of the Puerto Rico and  Sandwich, U.K. operations will continue, with employment reduction at  Barceloneta and Arecibo, Puerto Rico, to occur in the fourth quarter of 2005  in anticipation of cessation of operations at the Arecibo plant in the next  few years. The sale of the Cruce Davila, Puerto Rico, plant is also being  pursued. Since 2003, Pfizer has announced plans to reduce the number of  plants in its global networks by more than 25%.

  

•

Realigning our European marketing  teams and implementing initiatives designed to improve the effectiveness of  our field force in Japan. During the third quarter of 2005, we completed a  major reorganization of the U.S. field force, reshaping the management  structure to be more responsive to commercial trends as the Medicare  Modernization Act takes effect and driving greater sales-force accountability  in preparation for the upcoming launch of new medicines.

  

•

Pursuing savings in information  technology resulting from significant reductions in application software  (already reduced from about 8,000 at the time of the Pharmacia acquisition in  2003 to about 4,000 today, with considerable further reductions planned) and  data centers (to be reduced from 17 to 4), as well as rationalization of  service providers, while enhancing our ability to invest in innovative technology  opportunities to further propel our growth.

  

•

Reducing costs in purchased goods  and services. Purchasing initiatives will focus on rationalizing suppliers,  leveraging the approximately $16 billion of goods and services that  Pfizer purchases annually, improving demand management to optimize levels of  outside services needed and strategic sourcing from lower-cost sources. For  example, savings from demand management will be derived in part from  reductions in travel, entertainment, consulting and other external service  expenses. Facilities savings are being found in site rationalization, energy  conservation, and renegotiated service contracts.

REVENUES

Total revenues decreased 5% in the third quarter and wereflat in the first nine months of 2005, as compared to the same periods in 2004.The revenue decrease reflects the loss of exclusivity of key products andregulatory actions on the selective COX-2 inhibitors and other nonspecificnon-steroidal anti-inflammatory drug (NSAID) products, which has resulted in a significantdecline in prescription volume in the arthritis market. The decrease alsoreflects lower prescription growth and increased competition in key markets inthe U.S., such as the lipid-lowering market, where the rate of growth in thethird quarter declined significantly versus the first half of the year; and theerectile-dysfunction market, which has been in decline compared to 2004. Inaddition, although we anticipate a positive long-term impact of our initiativedesigned to increase the efficiency of our U.S. Human Health field forcethrough stronger alignment with our customers (completed in September 2005),the short-term impact was a tempering of revenue performance in the thirdquarter. Partially offsetting these impacts in the first nine months of 2005was the solid performance in the aggregate of the balance of our broadportfolio of patent-protected medicines.

Changes in foreign exchange rates increased revenues in the thirdquarter of 2005 by $175 million, or 1.4%, and increased revenues in thefirst nine months of 2005 by $909 million, or 2.4%, compared to the sameperiods in 2004. The foreign exchange impact on the third quarter and first ninemonths of 2005 revenue comparisons to the same periods in 2004 was due to theweakening of the U.S. dollar relative to many foreign currencies, especiallythe euro. We expect 2005 revenues for the full year, at current foreignexchange rates, to evidence a modest decline relative to 2004, although asomewhat larger decline than previously anticipated, reflecting lower U.S.Human Health revenues.

The impact of price changes on revenues was 3.2% in the thirdquarter of 2005 and 2.8% in the first nine months of 2005.

The loss of patent protectionwith respect to any of our major products could have a material adverse effecton revenue and net income. We expect a substantial impact from the loss ofexclusivity of certain major products over the next few years. 

Deductions from Revenues

As is typical in the pharmaceutical industry, our grossproduct sales are subject to a variety of deductions, primarily representingrebates and discounts to government agencies, wholesalers and managed careorganizations. These deductions represent estimates of the related liabilitiesand, as such, judgment is required when estimating the impact of these sales deductionson gross sales for a reporting period. Historically, our adjustments to actualhave not been material; on a quarterly basis, they generally have been lessthan 0.5% of Human Health net sales and can result in either a net increase ora net decrease to income.

Rebates under Medicaid and related state programs reducedrevenues by $257 million and $956 million for the three months and ninemonths ended October 2, 2005 and $338 million and $1.0 billionfor the three months and nine months ended September 26, 2004.Performance-based contracts also provide for rebates to several customers.Contract rebates reduced revenues by $513 million and $1.7 billionfor the three months and nine months ended October 2, 2005 and $501 millionand $1.5 billion for the three months and nine months ended September 26,2004. These contracts are with managed care customers, including healthmaintenance organizations and pharmacy benefit managers, who receive rebatesbased on the achievement of contracted performance terms for products. Rebatesare product-specific and, therefore, for any given year are impacted by the mixof products sold. Chargebacks (primarily discounts to federal government agencies)reduced revenues by $324 million and $916 million for the threemonths and nine months ended October 2, 2005 and $290 million and $864 millionfor the three months and nine months ended September 26, 2004.

Our accruals for Medicaid rebates, contract rebates andchargebacks totaled $1.7 billion at October 2, 2005 andDecember 31, 2004.

Revenues by Country

Revenues by country for the thirdquarter and first nine months of 2005 and the changes from the same periods in2004 follow:

Third  Quarter

(millions  of dollars)

2005

% of  Revenues

2004

% of  Revenues

%  Change

  

United States

$

6,395

52.5

%

$

7,377

57.5

%

(13)%

Japan

848

7.0

760

5.9

12    

All other

4,946

40.5

4,694

36.6

5    

Consolidated

$

12,189

100.0

%

$

12,831

100.0

%

(5)   

  

  

First  Nine Months

(millions  of dollars)

2005

% of  Revenues

2004

% of  Revenues

%  Change

  

United States

$

19,558

51.9

%

$

21,122

56.2

%

(7)%

Japan

2,631

7.0

2,309

6.1

14    

All other

15,516

41.1

14,162

37.7

10    

Consolidated

$

37,705

100.0

%

$

37,593

100.0

%

--    

Geographic Revenues by Segment

Geographic revenues by segment forthe third quarter and first nine months of 2005 and the changes from the sameperiods in 2004 follow:

Third  Quarter

Revenues

% Change  in Revenues

U.S.

International

U.S.

International

(millions  of dollars)

2005

2004

2005

2004

05/04

05/04

  

Human Health

$

5,609

$

6,619

$

4,943

$

4,669

(15)%

6%

Consumer Healthcare

493

453

428

398

9    

8   

Animal Health

228

231

275

244

(1)   

12   

Other

65

74

148

143

(14)   

4   

Total Revenues

$

6,395

$

7,377

$

5,794

$

5,454

(13)   

6   

  

  

First  Nine Months

Revenues

% Change  in Revenues

U.S.

International

U.S.

International

(millions  of dollars)

2005

2004

2005

2004

05/04

05/04

  

Human Health

$

17,203

$

18,967

$

15,426

$

14,066

(9)%

10%

Consumer Healthcare

1,439

1,290

1,396

1,234

12    

13   

Animal Health

710

647

866

740

10    

17   

Other

206

218

459

431

(5)   

6   

Total Revenues

$

19,558

$

21,122

$

18,147

$

16,471

(7)   

10   

Human Health

Pfizer's Human Health business continued to show solid performance in manyof our products, although challenges to revenue more than offset thatperformance.

Pfizer's Human Health worldwide revenues declined 7% in the third quarter of2005 compared to the third quarter of 2004 and 1% year-to-date. In the U.S.,Human Health revenues declined 15% in the third quarter of 2005 compared to thethird quarter of 2004 and 9% year-to-date. The loss of exclusivity on keyproducts (primarily Neurontin) has resulted in a decline in third-quarterworldwide revenues of approximately $800 million and year-to-date worldwiderevenues of approximately $2.4 billion in comparison to the same periodsin the prior year. The regulatory actions relating to Celebrex and thesuspension of sales of Bextra have contributed to an additional decline inthird-quarter 2005 selective COX-2 inhibitor worldwide revenues of $754 million(down 67%) and year-to-date selective COX-2 inhibitor worldwide revenues of$2.0 billion (down 62%) in comparison to the same periods in the prioryear.

The third quarter of 2005 was also impacted by the overall market declinefor branded prescriptions in the U.S. Branded prescriptions in the U.S. declined3% in the third quarter of 2005 relative to the third quarter of 2004. Thethird quarter of 2005 also exhibited a significant change in growth trends relativeto the first half of the year in a number of U.S. therapeutic markets. Examplesinclude the branded statins market, where total prescriptions grew 7% in thethird quarter versus 10% in the first half of 2005, and theerectile-dysfunction market, with total prescriptions declining 7% in the thirdquarter versus zero growth in the first half of 2005.

Revenue information for severalof our major Human Health products, which includes three additional business daysin our fiscal calendar in the first quarter and nine months of 2005 compared tothe same periods in 2004, follows:

Third  Quarter

First  Nine Months

(millions  of dollars)  Product

Primary  Indications

2005 

%  Change  from 2004

2005 

%  Change  from 2004

  

**Cardiovascular  and  metabolic diseases:**

Lipitor

Reduction of  LDL cholesterol 

$2,897 

6 %

$8,829 

16 %

Norvasc

Hypertension

1,131 

9    

3,462 

8    

Cardura

Hypertension/Benign  prostatic hyperplasia

132 

(12)   

441 

(4)   

Accupril/Accuretic

Hypertension/Congestive  heart failure

77 

(51)   

250 

(50)   

Caduet

Reduction of  LDL cholesterol and hypertension

48 

927    

121 

249    

**Central  nervous   system disorders:**

Zoloft

Depression and  anxiety disorders

807 

1    

2,448 

2    

Neurontin

Epilepsy and  post-herpetic neuralgia

155 

(80)   

498 

(78)   

Geodon

Schizophrenia  and acute manic or mixed episodes associated with bipolar disorder

148 

18    

430 

33    

Xanax/Xanax XR

Anxiety/Panic  disorders

101 

--    

306 

13    

Aricept**

Alzheimer's  disease

85 

11    

255 

15    

Lyrica

Epilepsy,  post-herpetic neuralgia and diabetic peripheral neuropathy

80 

M+    

139 

M+    

Relpax

Migraine  headaches

67 

42    

170 

49    

**Arthritis  and pain:**

Celebrex

Arthritis pain  and inflammation, acute pain

446 

(44)   

1,258 

(45)   

Bextra

Arthritis pain  and inflammation

(73)

*    

(59)

*    

**Infectious  and  respiratory diseases:**

Zithromax/Zmax

Bacterial  infections

402 

19    

1,623 

38    

Zyvox

Bacterial infections

157 

30    

453 

38    

Vfend

Fungal  infections

106 

54    

285 

40    

Diflucan

Fungal  infections

103 

(52)   

370 

(54)   

**Urology:**

Viagra

Erectile  dysfunction

386 

(4)   

1,215 

1    

Detrol/Detrol LA

Overactive  bladder

231 

--    

705 

14    

**Oncology:**

Camptosar

Metastatic  colorectal cancer

229 

81    

674 

85    

Ellence

Breast cancer

86 

--    

273 

7    

Aromasin

Breast cancer

63 

61    

176 

88    

**Ophthalmology:**

Xalatan/Xalacom

Glaucoma and  ocular hypertension

338 

11    

1,011 

16    

**Endocrine  disorders:**

Genotropin

Replacement of  human growth hormone

200 

14    

604 

13    

**All other:**

Zyrtec/Zyrtec-D

Allergies

338 

2    

1,035 

10    

**Alliance  revenue:**

Aricept, Macugen, Mirapex, Olmetec,  Rebif and Spiriva

Alzheimer's  disease (Aricept), neovascular (wet) age-related macular degeneration  (Macugen), Parkinson's disease (Mirapex), hypertension (Olmetec), multiple  sclerosis (Rebif), chronic obstructive pulmonary disease (Spiriva)

267 

38    

757 

59    

  

*

Calculation  not meaningful.

**

Represents  direct sales under license agreement with Eisai Co., Ltd.

M+

Change  greater than one-thousand percent.

Certain  amounts and percentages may reflect rounding adjustments.

Selected ProductDescriptions:

•

**Lipitor,** for the treatment  of elevated cholesterol levels in the blood, is the most widely used  treatment for lowering cholesterol and the best-selling pharmaceutical  product of any kind in the world. In our international markets, Lipitor  showed revenue growth of 14% in the third quarter of 2005, compared to the  third quarter of 2004. In the U.S., Lipitor revenues grew 1% in the third  quarter of 2005, compared to the third quarter of 2004. This performance  reflects in part an unexpectedly rapid slowdown in the U.S. lipid-lowering  market as a whole and marginal Lipitor prescription share erosion during the  quarter of one percentage point. Evidence of the substantial lipid-market  deceleration can be seen in category new-prescription growth rates for the  third quarter of 8% versus first-half growth of 17%, representing more than a  50% drop from robust trends exhibited during the first six months of this  year. Despite this market slowdown, Lipitor still accounts for more than 40%  of all lipid-lowering prescriptions, a 26.4% advantage versus its next  nearest competitor.

   

In September 2005, the FDA approved  Lipitor use to reduce the risk of stroke and myocardial infarction in  patients with type 2 diabetes. The FDA's decision was based on the findings  of the Collaborative Atorvastatin Diabetes Study (CARDS), a landmark trial of  more than 2,800 patients with type 2 diabetes, near-normal cholesterol, and  at least one other risk factor, such as high blood pressure or smoking. CARDS  showed that patients using Lipitor experienced 48% fewer strokes than those  on placebo. The CARDS study's steering committee stopped the trial nearly two  years earlier than planned because of the clinical benefits among patients who  took Lipitor. 

   

In addition, the FDA expanded the  Lipitor label to include data on the reduction in the incidence of stroke in  patients with multiple risk factors, as shown in the Anglo-Scandinavian  Cardiac Outcomes Trial (ASCOT) clinical trial. The ASCOT trial found that  Lipitor reduced the relative risk of stroke by 26% compared to placebo. The  study involved people with normal or borderline cholesterol and no prior  history of heart disease with controlled high blood pressure and at least  three other risk factors for heart disease, such as family history, age over  55, smoking, diabetes, and obesity. Patients with multiple risk factors,  including diabetes, face a greater threat of heart attack and stroke.  Reducing their risk of such cardiovascular events is extremely important.

  

•

**Norvasc** is the world's  most-prescribed branded medicine for treating hypertension. It achieved an  increased rate of growth in sales in the first nine months of 2005 compared  to same period in 2004 (8% in 2005 as compared to 4% in 2004), despite patent  expirations in many European Union (E.U.) countries. Norvasc maintains  exclusivity in many major markets globally, including the U.S., Japan, Canada  and Australia.

  

•

**Zoloft** is the  most-prescribed antidepressant in the U.S. It is indicated for the treatment  of major depressive disorder, panic disorder, obsessive-compulsive disorder  (OCD) in adults and children, post-traumatic stress disorder (PTSD),  premenstrual dysphoric disorder (PMDD) and social anxiety disorder (SAD).  Zoloft is approved for acute and long-term use in all of these indications,  with the exception of PMDD, and is the only approved agent for the long-term  treatment of PTSD and SAD, an important differentiating feature as these  disorders tend to be chronic.

**  **

In the U.S., in February 2005,  Pfizer implemented FDA instructions that require the makers of all currently  marketed antidepressants, including tricyclic agents, monoamine oxidase (MAO)  inhibitors, selective serotonin reuptake inhibitors such as Zoloft, selective  norepinephrine reuptake inhibitors and atypical antidepressants, to include a  black-box warning that antidepressants increased the risk of suicidal  thinking and behavior in children and adolescents in pooled, short-term  studies. In the nine completed clinical trials of Zoloft involving children  and adolescents, which included studies of Zoloft in children diagnosed with  depression, OCD, or both, no suicides occurred. The trials found no  statistically significant differences between Zoloft-treated children and  adolescents and placebo controls in their rates of suicide attempts or ideation.  

  

•

**Neurontin,** for use in  adjunctive therapy for epilepsy, is also approved in more than 60 markets for  the treatment of a range of neuropathic pain conditions. Neurontin has also  been approved for the management of post-herpetic neuralgia (PHN), a, painful  condition that affects many people in the aftermath of the viral infection  commonly known as shingles. Neurontin was the first oral medication approved  in the U.S. for the treatment of PHN.

  

In the latter half of 2004, Ivax  Corporation (Ivax), Alpharma Inc. (Alpharma) and Teva Pharmaceuticals  Industries Ltd. (Teva) launched generic versions of Neurontin (gabapentin)  at-risk, despite ongoing patent litigation. We are aggressively pursuing our  claims of patent infringement against Ivax, Alpharma, Teva and other generic  manufacturers. (See Part II, Item 1, *Legal Proceedings*.) Following  those at-risk launches, we launched generic gabapentin through Greenstone,  our U.S. generic pharmaceutical subsidiary. However, the introduction of  generic versions of gabapentin caused a 78% reduction in Neurontin sales for the  first nine months of 2005 as compared to the same period in 2004.

   

•

**Geodon**, a psychotropic  agent, is a dopamine and serotonin receptor antagonist indicated for the  treatment of schizophrenia and acute manic or mixed episodes associated with  bipolar disorder. Available in both an oral capsule and rapid-acting  intramuscular formulation, Geodon has been launched in 54 countries, where  more than six million prescriptions have been written for more than one  million patients worldwide. In the U.S., Geodon hit an all-time U.S. new  prescription share high of 6% in the third quarter and is now the  second-fastest-growing atypical anti-psychotic medication.

**   **

The Clinical Antipsychotic Trials  of Intervention Effectiveness schizophrenia study, supported by the National  Institute of Mental Health and recently published in the New England Journal  of Medicine, confirms that Geodon is an effective anti-psychotic and is less  likely to worsen weight, lipids, and glucose metabolism than other agents. In  fact, Geodon was associated with some improvement in these parameters. These  findings are noteworthy because of the higher prevalence of metabolic issues  among patients with schizophrenia and are consistent with previous  Pfizer-sponsored clinical trials involving Geodon.

**   **

•

**Lyrica**was****approved  by the FDA in June 2005 for adjunctive therapy for adults with partial onset  seizures. This latest indication builds on the earlier FDA approval of Lyrica  for two of the most common forms of neuropathic pain -- diabetic peripheral  neuropathy, a chronic neurologic condition affecting nearly three million Americans,  and post-herpetic neuralgia. Lyrica was launched in the U.S., Canada, and  Italy in September 2005 and is now approved in more than 50 countries and is  currently available in more than 25 markets. Market penetration has been  rapid; after one full year of Lyrica sales, Germany and the U.K. posted Lyrica  sales shares of 14.2% and 9.5%, respectively, in the anti-epileptic drug  market, surpassing those of many established competitors in both countries.  Clinical evidence favorable to  Lyrica also continues to grow. The September 2005  edition of *Epilepsia* focused on the medication's lack of interactions  with other drugs. Additionally, at the August 2005 meeting of the  International Epilepsy Congress, data from an independently conducted  meta-analysis showed Lyrica to be among the best in class for treatment of  drug-resistant epilepsy.

**   **

•

**Celebrex and Bextra**

  

  

On April 7, 2005, the FDA announced  a decision to require boxed warnings of potential cardiovascular risk for all  COX-2 pain relievers and all prescription NSAIDs, including older  non-specific drugs such as ibuprofen and naproxen. On July 29, 2005,  Pfizer and the FDA finalized the label changes for Celebrex. The final label  contains a boxed warning of potential serious cardiovascular and gastrointestinal  risks for Celebrex that are consistent with warnings for all other  prescription NSAIDs. The boxed warning provides that Celebrex is  contraindicated for patients who recently have undergone coronary artery  bypass graft surgery. The label recommends that Celebrex be prescribed at the  lowest effective dose for the shortest duration consistent with individual  patient treatment goals. Pfizer is continuing to conduct additional clinical  studies evaluating the benefits and risks of Celebrex.

  

The market for pain relievers has  shown considerable change since the withdrawal of Vioxx in September 2004.  Sales of Celebrex began to decline in the late 2004. However, following  regulatory reviews of these medicines in February 2005 in both the U.S. and the  E.U., the market for prescription pain relievers indicated lower, but  stabilizing levels compared to pre-Vioxx withdrawal levels. Revenues from  Celebrex in 2005, prior to the FDA's decision in April 2005, were already  expected to be significantly lower than in 2004.

   

In September 2005, with full  implementation of revised labeling, Pfizer began to focus renewed attention  on Celebrex, with the goal of making the pain reliever available to increased  numbers of patients. Celebrex is supported by a large body of scientific and  clinical-trial evidence of efficacy and safety accumulated over 10 years in  more than 40,000 patients worldwide. In July, the FDA approved a sixth  indication for Celebrex -- ankylosing spondylitis -- a form of spinal  arthritis that affects more than one million people in the U.S. 

   

In June 2005, the Committee for  Human Medicinal Products (CHMP) concluded its COX-2 referral process and  recommended that both Celebrex and Dynastat (parecoxib) remain available to  patients. The European Medicines Evaluation Agency (EMEA) has required new  labeling for all COX-2 drugs that includes a restriction on use for patients  with established heart disease or stroke and additional warnings to  physicians regarding use in patients with cardiovascular risk factors. This  new labeling was implemented for all COX-2 medicines across the E.U. in July  of 2005.

  

Further, the FDA decided that while  Bextra's cardiovascular risk could not be differentiated from other NSAIDs,  the additional, increased risk of rare but serious skin reactions associated  with Bextra, already described in its label, warranted its withdrawal from  the market. In 2004, we recorded $1.3 billion in revenue for Bextra. We  respectfully disagree with the FDA's position regarding the relative  risk/benefit profile of Bextra. However, in deference to the regulatory  agency's view, we suspended sales of the medicine pending further discussions  with the FDA. In addition, at the request of European and other regulators,  we suspended sales of Bextra in the E.U., Canada and many other markets  around the world.

   

In connection with the decision to  suspend sales of Bextra in the U.S., the E.U., and certain other markets, we  recorded certain charges totaling $1.2 billion ($762 million, net  of tax) in the first nine months of 2005. These pre-tax charges included  $1.1 billion related to the impairment of developed technology rights  associated with Bextra and $7 million related to the write-off of  machinery and equipment, both of which are included in *Other  (income)/deductions-net*; $56 million in write-offs of inventory and  exit costs, included in *Cost of sales*; $8 million related to the  costs of administering the suspension of sales, included in *Selling,  informational and administrative expenses;*and $212 million for an  estimate of customer returns, primarily included against *Revenues.* Substantially  all of these charges were recorded in the first quarter of 2005.

  

•

**Zithromax**, whose composition  of matter patent in the U.S. expires in November 2005, remained the  number-one prescribed oral antibiotic during the third quarter of 2005,  despite the end of active sales promotion in July, when the U.S. sales force  began promoting Zmax. Sales in the U.S. are expected to be adversely affected  by the loss of market exclusivity beginning in November 2005.

   

•

**Zmax,** a single-dose,  sustained-release form of azithromycin, was introduced in the U.S. in July  2005. Zmax has surpassed all other recent antibiotic introductions (including  line extensions) in week 10 prescription volume, even though the Zmax launch  occurred in the summer, before the beginning of the respiratory season.  Single-dose Zmax delivers higher azithromycin serum concentrations during the  first 24 hours than Zithromax and assures complete compliance compared to  multi-dose regimes, demonstrating a clear benefit of the new medication. A  supplemental Marketing Authorization Application (MAA) for Zmax was approved  in Europe in September 2005.

   

•

**Diflucan** is a systemic  antifungal. The decrease in sales in the first nine months of 2005 compared  to the same period in 2004 is mainly due to loss of exclusivity in the U.S.  in July 2004.

  

•

**Viagra** remains the leading  treatment for erectile dysfunction and one of the world's most recognized  pharmaceutical brands, with more than 63% of U.S. sales in its market of  phosphodiesterase-5 (PDE5) inhibitors through August 2005, even as the entire  market's sales were down for the period.

  

In addition, Viagra faces  aggressive competition from other global brands. Year-to-date 2005 Viagra  sales are ahead 1% worldwide over last year, and third-quarter 2005 sales are  down 4% from the same period last year. Pfizer plans to introduce new branded  advertising compliant with our direct-to-consumer advertising guidelines to  highlight the unique clinical profile for Viagra, as well as new unbranded  advertising to address the needs of potential new patients who may be  hesitant to try any medication for erectile dysfunction.

  

On July 8, 2005, the FDA  approved an update to the Viagra label to reflect rare post-marketing reports  of non-arteritic anterior ischemic optic neuropathy (NAION) in patients  taking PDE5 inhibitor medications. The updated label notes that in rare  instances, men taking PDE5 inhibitors, including Viagra, reported a sudden  decrease or loss of vision in one or both eyes and that it is not possible to  determine whether these events are related directly to these medicines, to  the patient's underlying vascular risk factors, to a combination of these  factors, or other factors. Most of the reported NAION cases occurred in  Viagra users with underlying anatomic or vascular risk factors associated with  the development of NAION.

  

•

**Camptosar** is a semisynthetic  camptothecin derivative that works by inhibiting the topoisomerase 1 enzyme,  which is involved in cancer cell replication. Camptosar is indicated as  first-line therapy for metastatic colorectal cancer in combination with  5-fluorouracil and leucovorin. It is also indicated as second-line therapy for  patients in whom metastatic colorectal cancer has recurred or progressed  despite following initial fluorouracil-based therapy. Camptosar is for  intravenous use only. Revenue growth of 85% in the first nine months of 2005  compared to the same period in 2004 was impacted in part by Pfizer's  acquisition of marketing rights to Campto/Camptosar in Europe and Asia  (except Japan) in late 2004. Among current oncology medications, the National  Comprehensive Cancer Network, an alliance of 19 of the world's leading cancer  centers, has issued guidelines recommending Camptosar as an option across all  lines of treatment for advanced colorectal cancer. 

**   **

•

**Xalatan/Xalacom,**a  prostaglandin analogue used to lower the intraocular pressure associated with  glaucoma and ocular hypertension, is the most-prescribed branded glaucoma  medicine in the world. Clinical data showing its  advantages in treating intra-ocular pressure compared with beta blockers  should support the continued growth of this important medicine.

**   **

•

**Zyrtec** provides strong,  rapid and long-lasting relief for seasonal and year-round allergies and hives  with once-daily dosing. Zyrtec continues to be the most-prescribed  antihistamine in the U.S. in a challenging market. The increase in sales in  the first nine months of 2005 compared to the same period in 2004 is  attributable to stabilization in the prescription antihistamine market  subsequent to the Rx to over-the-counter switch of loratadine as the majority  of the managed care plans have completed their formulary tier changes in this  category. 

**   **

•

**Macugen**, a treatment for  neovascular (wet) age-related macular degeneration, is a product whose  revenues are included in alliance revenues. It was launched in the U.S. in  January 2005 and launched in Canada in September 2005. We anticipate that the  European Commission will grant marketing authorization for Macugen during the  fourth quarter of 2005. 

**   **

•

**Caduet,**a single pill  combining Lipitor and Norvasc, has successfully completed the Mutual  Recognition Procedure (MRP) in the E.U. and is the first multi-target combination product  to receive a broad approval for prevention of cardiovascular events in the E.U. Caduet is now approved in the following E.U. countries:  France, Spain, Portugal, Austria, Iceland, Luxembourg, Cyprus, the Czech  Republic, Hungary, Latvia, Lithuania, Malta, Poland, Slovakia and Slovenia.  It is indicated for prevention of cardiovascular events in hypertensive  patients with  three concomitant cardiovascular risk factors, normal to  mildly elevated cholesterol levels, without clinically evident coronary heart  disease, where combined use of amlodipine and low dose atorvastatin is  considered appropriate, and in accordance with current treatment guidelines.  The Caduet Marketing Authorization application has been officially withdrawn  from the MRP in Belgium, Denmark, Estonia, Ireland, Italy, Netherlands,  Norway, the U.K.,  Sweden, Germany, Finland and Greece. These countries had reservations as to  whether the benefit of Caduet, the first cardiovascular, multi-target, fixed  combination product, had been demonstrated,****based upon current  European regulatory guidelines for fixed combination products. As a result,  these countries did not mutually recognize the proposed label and Pfizer  decided to withdraw the application from these countries. Pfizer will  continue to explore regulatory approval opportunities for Caduet. 

Consumer Healthcare

Revenues of our Consumer Healthcare business, which includethree additional business days in our fiscal calendar in the first quarter and ninemonths of 2005 compared to the same periods in 2004, follow:

Third  Quarter

First  Nine Months

(millions  of dollars)

2005

2004

% Change

2005

2004

%  Change

  

Consumer Healthcare

$

921

$

851

8%

$

2,835

$

2,524

12%

The increase in ConsumerHealthcare revenues in the third quarter and first nine months of 2005, as comparedto the same periods in 2004, was attributable to:

•

the 4% increase in the third  quarter and 13% increase in the first nine months of 2005 in sales of  Listerine mouthwash, which benefited from the U.S. launch of Listerine  Whitening in April 2005, as well as continued strong performance in  international markets;

  

•

growth from Sudafed and other  upper-respiratory products, Zantac, and tobacco dependence products; 

  

•

inclusion of Purell sales in 2005 following  the acquisition of the Purell brand in November 2004; and

  

•

the favorable impact of the  weakening of the U.S. dollar relative to many foreign currencies.

Animal Health

Revenues of our Animal Healthbusiness, which include three additional business days in our fiscal calendarin the first quarter and nine months of 2005 compared to the same periods in2004, follow:

Third  Quarter

First  Nine Months

(millions  of dollars)

2005

2004

% Change

2005

2004

% Change

  

Livestock products

$

301

$

287

5%

$

958

$

840

14%

Companion animal products

202

188

8   

618

547

13   

Total Animal Health

$

503

$

475

6   

$

1,576

$

1,387

14   

The increase in Animal Healthrevenues in the third quarter and first nine months of 2005, as compared to thesame periods in 2004, was attributable to:

•

in livestock, the continued  performance of Draxxin (for treatment of respiratory disease in cattle and  swine) in Europe and in the U.S., as well as Spectramast (antibiotic  formulated to treat clinical mastitis) which was launched in the U.S. in May  2005, partially offset by a slowdown in the third quarter due to delay in the  U.S. cattle season;

  

•

in companion animal, increased  promotional activities throughout our markets resulted in Revolution and  Clavamox growing at double-digit rates for the******first nine  months of 2005, and the launch of Simplicef (small animal anti-infective) in  the U.S. in the fourth quarter of 2004; and

  

•

the favorable impact of the  weakening of the U.S. dollar relative to many foreign currencies.

COSTS AND EXPENSES

Cost of Sales

Cost of sales grew 16% in the third quarter of 2005 and 19%for the first nine months of 2005, and increased as a percentage of revenues,as compared with the prior year periods. The increases reflect unfavorable geographic,segment and product mix, and adverse changes in production volume, among otherfactors. In the first quarter of 2005, we also recorded charges for write-offsof inventory and exit costs related to the suspension of Bextra sales (seeNote 2, *Asset Impairment Charge and Other Costs Associated with theSuspension of Bextra Sales*).

Cost of sales as a percentage of revenues will remain underpressure throughout the remainder of 2005.

Selling, Informational and Administrative Expenses

Selling, informational and administrative expenses decreased3% in the third quarter and were flat in the first nine months of 2005, ascompared to the same periods in 2004, reflecting an increase in merger-relatedsynergies, and the impact of the Company's AtS productivity initiative, partiallyoffset by the unfavorable impact of foreign exchange.

Research and Development Expenses

Research and development (R&D) expenses decreased 6% inthe third quarter and increased 1% in the first nine months of 2005, ascompared to the same periods in 2004. The decline in the third quarter of 2005 reflectsthe initial benefits associated with the AtS productivity initiative andchanges in year-over-year timing of various expenses.

*Product Developments*

We continue to invest in R&D to provide future sourcesof revenue through the development of new products, as well as throughadditional uses for existing in-line and alliance products. We have a broad anddeep pipeline of medicines in development. However, there are no assurances asto when, or if, we will receive regulatory approval for additional indicationsfor existing products or any of our other products in development.

Certain significant regulatory actions by, and filingspending with, the FDA and other regulatory authorities follow:

Recent FDA Approvals:

**Product**

**Indication**

** **

**Date Approved**

  

Aromasin

Treatment of early  breast cancer in post-menopausal women 

October 2005

  

Lipitor

Reduce the risk  of stroke and myocardial infarction in patients with type 2 diabetes

September 2005

  

Norvasc

For treatment  of angiographically documented coronary artery disease

September 2005

  

Celebrex

For the relief  of the signs and symptoms associated with ankylosing spondylitis

July 2005

  

Lyrica

Add-on therapy  for adult epilepsy patients with partial onset seizures

June 2005

  

Revatio

Oral treatment  for adult pulmonary arterial hypertension (PAH)

June 2005

  

Zmax  

Single dose  version of Zithromax for acute bacterial sinusitis and community-acquired  pneumonia.

June 2005

  

Zyvox

For the  treatment of bacterial infections in pediatric patients

May 2005

  

Depo-SubQ  Provera

Subcutaneous  formulations to treat pain associated with endometriosis.

March 2005

  

Ellence

Adjuvant  long-term cancer treatment

March 2005

Pending U.S. New DrugApplications (NDAs) and Supplemental Filings:

**Product**

**Indication**

** **

**Date Submitted**

  

Sutent

Treatment of  metastatic renal cell carcinoma and malignant gastrointestinal stromal tumors

August 2005

  

Anidulafungin  

Treatment of candidemia  and invasive candidiasis

August 2005

  

Treatment of  esophageal candidiasis

May 2005

  

Aricept

Treatment of  severe Alzheimer's disease

August 2005

  

Genotropin

Treatment of  short stature and growth problems resulting from Turner's syndrome

June 2005

  

Vfend

Pediatric  filing 

June 2005

  

Indiplon

Modified-release  tablets for treatment of multiple aspects of insomnia

May 2005

  

Immediate-release  capsules for treatment of multiple aspects of insomnia

April 2005

  

Exubera

Inhaled form of  insulin for use in adults with type 1 and type 2 diabetes

December 2004

  

Oporia

Vaginal atrophy

December 2004

  

Dalbavancin

Treatment of  Gram-positive bacterial infections

December 2004

  

Norvasc

Reduction of  cardiovascular risk, including risk of coronary heart disease, myocardial  infarction, cardiovascular  procedures and strokes

August 2004

  

Fragmin

Use in oncology  patients to reduce cardiac toxicity associated with chemotherapy

March 2004

In September 2005, we received "not-approvable"letters from the FDA for **Oporia** for the prevention of post-menopausalosteoporosis, and **Dynastat** (parecoxib), an injectable prodrug forvaldecoxib for the treatment of acute pain. Pfizer plans to discuss these "not-approvable"letters with the FDA.

In September 2005, an FDA advisory committee recommendedthat the FDA approve **Exubera**, an inhaled form of insulin for use inadults with type 1 and type 2 diabetes. The FDA is not obligated to follow therecommendation of the advisory committee. In October 2005, the FDA extended thereview period for Exubera to study more data on the diabetes treatment.

An NDA for **Sutent**, a novel multi-targeted oralcompound for treatment of metastatic renal cell carcinoma (mRCC) and malignantgastrointestinal stromal tumors (GIST), was submitted to the FDA on August 10,2005. The FDA has accepted this submission and granted Sutent priority-reviewstatus for this important cancer therapy. Priority designation allows for anexpedited review of the NDA filing and is intended for product candidates thatmay provide a significant improvement compared to marketed products. An MAA forSutent was also submitted to European regulatory authorities during thequarter.

On September 14, 2005, Pfizer completed the acquisition ofVicuron. **Anidulafungin**, one of the key products acquired in the Vicuronacquisition, is a novel, broad-spectrum antifungal agent of the echinocandinclass that is currently under review by the FDA. The filing for the treatmentof candidemia/invasive candidiasis has been granted priority-review status. Ina Phase 3 trial, anidulafungin demonstrated clinical efficacy greater thanfluconazole, including disease due to Candida glabrata, with a comparablesafety profile in the treatment of candidemia/invasive candidiasis. Pfizer iscurrently assessing the potential of anidulafungin in treating additionalpatient populations.

The FDA hasdesignated as approvable the NDA for **Dalbavancin**, a new injectableantibiotic to treat Gram-positive infections, which was also acquired in theVicuron acquisition. We anticipate a rapid and successful resolution of outstandingissues to allow final NDA approval in the coming months. The addition of thesetwo medications would broaden Pfizer's existing portfolio of anti-infectives,where the Company has a long history of providing patients and physicians withlife-saving medicines.

**   **

Other Regulatory Approvals and  Filings:

   

**Product**

**Description  of Event**

**Date  Approved**

  

**Date Submitted**

**  **

** **

** **

** **

Revatio

Approval in the  E.U. for treating PAH

November 2005

--

  

Application  submitted in Canada for treating PAH

--

December 2004

**  **

** **

** **

** **

Geodon

Approval in  the E.U. for treating manic or mixed episodes of moderate severity in bipolar  disorder

October 2005

--

  

Aromasin

Approval in  the E.U. for treating early breast cancer in post-menopausal women

August 2005

--

  

Sutent

Application  submitted in the E.U. for the treatment of metastatic renal cell carcinoma  and malignant gastrointestinal stromal tumors

--

August 2005

  

Aricept

Approval in  Canada for fast dissolving tablet

July 2005

--

  

Caduet

Approval in  certain E.U. countries for cardiovascular event prevention

July 2005

--

  

Lyrica

Approval in  Canada for neuropathic pain

June 2005

--

  

Macugen

Approval in  Canada and Brazil for age-related macular degeneration (AMD)

May 2005

--

  

Application  submitted in Switzerland for AMD

--

January 2005

  

Application  submitted in the E.U. and Australia for AMD

--

September 2004

  

Fragmin

Approval in  the E.U. for treatment of deep vein thrombosis in cancer patients

April 2005

--

  

Vfend

Approval in  Japan for treatment of aspergillosis

April 2005

--

  

Approval  for treatment of serious, invasive, fluconazole-resistant candida infections  and first-line treatment of candidemia in non-neutropenic patients was  granted in the E.U.

January 2005

--

  

Zmax

Application  submitted in the E.U. for sustained release

--

October 2004

  

Genotropin

Application  submitted in Japan for treatment of short stature and growth problems

--

July 2004

  

Neurontin

Application  submitted in Japan for epilepsy

--

April 2004

  

Exubera

Application  submitted in the E.U. as an inhaled form of insulin for use in adults with  type 1 and type 2 diabetes

--

February 2004

In September and October of2005, the CHMP of the European Medicines Evaluation Agency issued positiveopinions recommending that marketing authorizations be granted by the EuropeanCommission for **Macugen** and **Exubera**, respectively. The EuropeanCommission is not obligated to follow the opinions of the CHMP. The EuropeanCommission is expected to act upon the CHMP recommendations for Macugen by theend of 2005 and Exubera in early 2006.

Ongoing or planned clinical trials for additional uses anddosage forms for our products include:

**Product**

**Indication**

  

Celebrex

Sporadic  adenomatous polyposis - a precancerous condition caused by growths (polyps)  in the intestines

  

Camptosar IV

Adjuvant  colorectal cancer

  

Gastric cancer

  

Geodon

Bipolar relapse prevention

Macugen

Diabetic Macular Edema

  

Xalatan (new delivery  device)

Ocular hypertension

  

Zyvox

Catheter-related  infections

  

Bone and joint  infections

Drugcandidates in late-stage development include varenicline, a nicotine-receptorpartial agonist for smoking cessation, which has concluded Phase 3 trials;maraviroc (UK-427,857), a CCR-5 receptor antagonist for HIV;torcetrapib/atorvastatin, a combination CETP inhibitor/statin for heartdisease; asenapine, for schizophrenia and bipolar disorder, underco-development with Akzo Nobel's Organon healthcare unit; andZithromax/chloroquine for treatment of malaria. The Company anticipates filingan NDA with the FDA for varenicline by the end of 2005. The FDA has grantedfast-track designation for maraviroc's clinical development program.

**Torcetrapib/atorvastatin**,which combines the new chemical entity torcetrapib (a CETP inhibitor discoveredby Pfizer that raises HDL-cholesterol) with atorvastatin (Lipitor), is****continuingin global Phase 3 clinical trials. This comprehensive 12,000-subject developmentprogram includes three comparative atherosclerotic imaging trials (a coronaryintravascular ultrasound study and two carotid ultrasound studies), as well asa full range of blood-lipid efficacy studies comparing torcetrapib/atorvastatinto Lipitor, other statins and fibrates. In addition to these Phase 3 studies,the development program includes a definitive mortality and morbidity trialthat is enrolling 13,000 patients.

Despite effective treatments,cardiovascular disease remains the number one killer worldwide with a residualrelative risk of 60 to 70% after treatment with statins. Therefore, the primaryobjective of the torcetrapib/atorvastatin development program is to provideclear evidence that substantially raising HDL-cholesterol and further loweringLDL-cholesterol can reduce cardiovascular risk beyond what can be achieved withcurrent treatments. Torcetrapib will be developed with atorvastatin in order torigorously test this hypothesis and the new CETP inhibition mechanism ofaction. This development program represents a major commitment by Pfizer to significantlyadvance the understanding of lipids and atherosclerosis in order to provide animportant new tool for patients and prescribers in preventing and treating theglobal burden of cardiovascular disease**.**

The clinical development program for the selective cytotoxicagent edotecarin was terminated in the first quarter of 2005; developmentrights for edotecarin were returned to Banyu Pharmaceuticals, Inc.

Pfizer's participation in the clinical development programsfor capravirine, a non-nucleoside reverse transcriptase inhibitor for HIV, andDaxas, a phosphodiesterase-4 inhibitor for chronic obstructive pulmonarydisease and asthma, was terminated in the second quarter 2005; development rightswere returned to Shiongi & Co. Ltd and Altana Pharma, Inc. respectively.

Additional product-related programs are in various stages ofdiscovery and development.

Merger-Related In-Process Research and DevelopmentCharges

The estimated value of merger-related in-process researchand development charges (IPR&D) is expensed at the acquisition date. In2005, we expensed $1.7 billion of IPR&D, primarily related to ouracquisition of Vicuron Pharmaceuticals, Inc. on September 14, 2005 ($1.4 billion)and our acquisition of Idun Pharmaceuticals, Inc. on April 12, 2005 ($250 million).In 2004, we expensed $955 million of IPR&D, primarily related to ouracquisition of Esperion Therapeutics, Inc. on February 10, 2004.

Adapting to Scale Initiative

We incurredthe following costs in connection with our Adapting to Scale (AtS) initiative,which was announced in the second quarter of 2005:

(millions  of dollars)

Three  Months  Ended  Oct. 2,  2005

Nine  Months  Ended  Oct. 2,  2005

  

Implementation  costs(a)

$

104

$

136

Restructuring  charges(b)

153

174

Total AtS costs

$

257

$

310

   

(a)

Included in *Cost of sales*  ($36 million),*Selling, informational and administrative expenses*  ($60 million), and *Research and development**expenses*  ($8 million) for the three months ended October 2, 2005, and  included in *Cost of sales* ($37 million), *Selling,  informational and administrative expenses*($81 million), and *Research  and development expenses* ($18 million) for the nine months ended  October 2, 2005.

(b)

Included  in *Restructuring charges and merger-related costs.*

In connection with the AtSinitiative, Pfizer management has performed a comprehensive review of ourprocesses, organizations, systems and decision-making procedures, in acompany-wide effort to improve performance and efficiency. We expect the costsassociated with this multi-year effort to continue through 2008 and to totalapproximately $4 billion to $5 billion, on a pre-tax basis. Theactions associated with the AtS initiative will include restructuring charges,such as asset impairments, exit costs and severance costs (including anyrelated impacts to our benefit plans, including settlements and curtailments)and associated implementation costs, such as accelerated depreciation charges,primarily associated with plant network optimization efforts, and expensesassociated with system and process standardization and the expansion of sharedservices. 

Through October 2, 2005, the restructuring chargesprimarily relate to employee termination costs at our manufacturing facilitiesin North America and the implementation costs primarily relate to system andprocess standardization and to expansion of shared services. 

The components of restructuringcosts associated with AtS follow:

(millions  of dollars)

Nine  Months  Ended  Oct. 2,  2005

Utilization  Through  Oct. 2,  2005

 

Accrual  at  Oct. 2,  2005

(a)

Employee  termination costs

$

106

$

49

$

57

Asset  impairments

62

62

--

Other

6

--

6

  

$

174

$

111

$

63

  

(a)

Included  in *Other current liabilities.*

During the three months endedOctober 2, 2005, we expensed $85 million for *Employee termination costs*,$62 million for *Asset impairments* and $6 million in *Other*.Through October 2, 2005, *Employee termination* costs represent theapproved reduction of the workforce by 922 employees, mainly inmanufacturing, sales and research. We notified affected individuals and 903employees were terminated as of October 2, 2005. *Employee terminationcosts* are recorded as incurred and include accrued severance benefits, pensionand postretirement benefits. *Asset impairments* primarily include chargesto write down intangible assets, and property, plant and equipment. *Other*primarily includes costs to exit certain activities.

Merger-Related Costs

We incurred the following merger-relatedcosts primarily in connection with our acquisition of Pharmacia Corporation(Pharmacia), which was completed on April 16, 2003:

Three  Months Ended

Nine  Months Ended

(millions  of dollars)

Oct. 2,  2005

Sept. 26,  2004

Oct. 2,  2005

Sept. 26,  2004

  

Integration costs(a)

$

93

$

113

$

390

$

367

Restructuring costs(a)

61

77

232

359

Total  merger-related costs

$

154

$

190

$

622

$

726

 

 
(a)

Included  in *Restructuring charges and merger-related costs*.

 
In connection with the acquisition of Pharmacia, Pfizermanagement approved plans to restructure and integrate the operations of bothlegacy Pfizer and legacy Pharmacia to combine operations, eliminate duplicativefacilities and reduce costs. Total merger-related expenditures expected to beincurred during 2003 through 2005 to achieve anticipated synergies are about$5.1 billion, on a pre-tax basis, with $5.0 billion incurred throughOctober 2, 2005. The restructuring of our operations as a result of ouracquisition of Pharmacia includes consulting, systems integrations, severance,costs of vacating duplicative facilities, contract termination and other exitcosts.

Through April 15, 2004, werecorded restructuring costs associated with employee terminations and exitingcertain activities of legacy Pharmacia as liabilities assumed in the purchasebusiness combination and recorded an increase to goodwill. Changes to previousestimates of restructuring costs included as part of the purchase allocation ofPharmacia are recorded as a reduction to goodwill or an expense to operations,as appropriate. Restructuring costs incurred for legacy Pfizer andrestructuring costs incurred after April 15, 2004 for legacy Pharmacia arecharged to the results of operations.

The components ofmerger-related restructuring costs associated with legacy Pfizer and legacyPharmacia follow:

(millions  of dollars)

Total

Utilization  Through  Oct. 2,  2005

(a)

Accrual  at  Oct. 2,  2005

(b)

  

Costs capitalized through April 15,  2004: 

Employee  termination costs

$

1,535

$

1,502

$

33

Other

624

517

107

$

2,159

$

2,019

$

140

Costs expensed:  

Employee  termination costs

$

590

$

508

$

82

Asset  impairments

421

421

--

Other

96

74

22

  

$

1,107

$

1,003

$

104

  

(a)

Includes  insignificant adjustments to original amounts established.

(b)

Included  in *Other current liabilities.*

During the three months ended October 2, 2005 and September26, 2004, we expensed $1 million and $53 million for *Employeetermination costs*, $53 million and $8 million for *Assetimpairment*, and $7 million and $16 million in *Other*.During the first nine months of 2005 and 2004, we expensed $73 million and$201 million for *Employee termination costs*, $131 million and$122 million for *Asset impairment*, and $22 million and $31 millionin *Other*.**Through October 2, 2005, *Employee terminationcosts*represent the approved reduction of the legacy Pfizer and legacyPharmacia work force by 17,086 employees, mainly in corporate,manufacturing, distribution, sales and research. We notified affectedindividuals and 16,385 employees were terminated as of October 2,2005. *Employee termination costs* are recorded as incurred and includeaccrued severance benefits and costs associated with change-in-controlprovisions of certain Pharmacia employment contracts. *Asset impairments*primarilyinclude charges to write down property, plant and equipment. *Other*primarily includes costs to exit certain activities of legacy Pfizer and legacyPharmacia.

Other (Income)/Deductions - Net

In the first nine months of 2005, we recorded impairmentcharges of $1.1 billion related to the developed technology rights forBextra, a selective COX-2 inhibitor, and $7 million related to thewrite-off of machinery and equipment (see Note 2, *Asset ImpairmentCharge and Other Costs Associated with the Suspension of Bextra Sales*),both of which are included in *Other (income)/deductions - net*.

In addition, in connectionwith the suspension of Bextra sales, we recorded $56 million in write-offsof inventory and exit costs, included in *Cost of sales*; $8 millionrelated to the costs of administering the suspension of sales, included in *Selling,informational and administrative expenses;* and $212 million for anestimate of customer returns, primarily included against *Revenues.*Substantially all of these charges were recorded in the first quarter of 2005.

In the third quarter of 2004, Pfizer recorded alitigation-related charge of $369 million related to the resolution ofclaims against Quigley Company, Inc., a wholly owned subsidiary of Pfizer,which is included in *Other (income)/deductions - net*.

PROVISION FOR TAXES ON INCOME

In the first nine months of 2005, we recorded an income taxcharge of $1.7 billion, included in *Provision for taxes on income*,in connection with our decision to repatriate about $36.7 billion offoreign earnings in accordance with the *American Jobs Creation Act of 2004*(the Jobs Act). In the first quarter of 2005, we recorded an initial estimatedincome tax charge of $2.2 billion based on the decision to repatriate $28.3 billionof foreign earnings. In the second quarter of 2005, we reduced our originalestimate of the tax charge by $863 million and revised the repatriation offoreign earnings to $28.1 billion, principally as a result of guidanceissued by the U.S. Treasury in May 2005. In the second quarter of 2005, we alsorecorded an additional tax charge of $373 million, primarily due to ourdecision to repatriate an additional $8.6 billion of foreign earnings.

In the second quarter of 2005, we recorded a tax benefit of$586 million, primarily related to the resolution of certain taxpositions.

Our effective tax rate for continuing operations was 34.4%for the first nine months of 2005 compared to 19.4% in the same period in 2004.The increase in the effective tax rate for the first nine months of 2005 is dueto the previously mentioned tax charge associated with the repatriation offoreign earnings and a $1.7 billion non-deductible charge for IPR&D, primarilyrelating to our acquisition of Vicuron Pharmaceuticals, Inc. and IdunPharmaceuticals, Inc., partially offset by the tax benefit of $586 millionprimarily related to the resolution of certain tax positions. Income taxes inthe first nine months of 2004 were impacted by a $955 million non-deductiblecharge for IPR&D, primarily relating to our acquisition of Esperion.

As of October 2, 2005, we intend to continue topermanently reinvest the earnings of our international subsidiaries and,therefore, we have not recorded a U.S. tax provision on the remaining amount ofunremitted earnings.

ADJUSTED INCOME

General Description of Adjusted Income Measure

Adjusted income is analternative view of performance used by management and we believe thatinvestors' understanding of our performance is enhanced by disclosing thisperformance measure. The Company reports Adjusted income in order to portraythe results of our major operations--the discovery, development, manufacture,marketing and sale of prescription medicines for humans and animals, as well asour over-the-counter products--prior to considering certain income statementelements. We have defined Adjusted income as Net income before discontinued operations,significant impact of purchase accounting for acquisitions, merger-related costsand certain significant items. The Adjusted income measure is not, and shouldnot be viewed as, a substitute for U.S. GAAP Net income.

TheAdjusted income measure is an important internal measurement for Pfizer. Wemeasure the performance of the overall Company on this basis. The following areexamples of how the Adjusted income measure is utilized. 

•

Senior management receives a  monthly analysis of the operating results of our Company that is prepared on  an Adjusted income basis;

  

•

The annual budgets of our Company  are prepared on an Adjusted income basis; and

  

•

Annual and long-term compensation,  including annual cash bonuses, merit-based salary adjustments and stock  options, for various levels of management, is based on financial measures  that include Adjusted income. The Adjusted income measure currently  represents a significant portion of target objectives that are utilized to  determine the annual compensation for various levels of management, although  the actual weighting of the objective may vary by level of management and job  responsibility and may be considered in the determination of certain  long-term compensation plans. The portion of senior management's bonus,  merit-based salary increase and stock option awards based on the Adjusted  income measure ranges from 10% to 30%.

Despite the importance of thismeasure to management in goal setting and performance measurement, we stressthat Adjusted income is a non-GAAP financial measure that has no standardized meaningprescribed by U.S. GAAP and, therefore, has limits in its usefulness toinvestors. Because of its non-standardized definition, Adjusted income (unlikeU.S. GAAP Net income) may not be comparable with the calculation of similarmeasures for other companies. Adjusted income is presented solely to permitinvestors to more fully understand how management assesses the performance ofour Company.

We also recognize that, as aninternal measure of performance, the Adjusted income measure has limitationsand we do not restrict our performance-management process solely to this metric.A limitation of the Adjusted income measure is that it provides a view of ourCompany's operations without including all events during a period such as theeffects of an acquisition, merger-related costs or amortization of purchasedintangibles and does not provide a comparable view of our performance to othercompanies in the pharmaceutical industry. We also use other specificallytailored tools designed to ensure the highest levels of performance in our Company.For example, our R&D organization has productivity targets, upon which itseffectiveness is measured. In addition, for senior levels of management, aportion of their long-term compensation is based on U.S. GAAP Net income.

Purchase Accounting Adjustments

Adjusted income is calculatedprior to considering certain significant purchase-accounting impacts, such asthose related to our acquisitions of Pharmacia, Vicuron and Esperion as well asnet-asset acquisitions. These impacts can include charges for purchased in-processresearch and development, the incremental charge to cost of sales from the saleof acquired inventory that was written up to fair value and the incrementalcharges related to the amortization of finite-lived intangible assets for the increaseto fair value. Therefore, the Adjusted income measure includes the revenuesearned upon the sale of the acquired products without considering theaforementioned significant charges. 

Certain of the purchase-accountingadjustments associated with a business combination, such as the amortization ofintangibles acquired in connection with our acquisition of Pharmacia, can occurfor up to 40 years (these assets have a weighted-average useful life ofapproximately 10 years), but this presentation provides an alternative view ofour performance that is used by management to internally assess businessperformance. We believe the elimination of amortization attributable toacquired intangible assets provides management and investors an alternativeview of our business results by trying to provide a degree of parity to internallydeveloped intangible assets for which research and development costs have beenpreviously expensed.

However, a completely accuratecomparison of internally developed intangible assets and acquired intangibleassets cannot be achieved through Adjusted income. This component of Adjustedincome is derived solely with the impacts of the items listed in the firstparagraph of this section. We have not factored in the impacts of any otherdifferences in experience that might have occurred if Pfizer had discovered anddeveloped those intangible assets on its own and this approach does not intend tobe representative of the results that would have occurred in thosecircumstances. For example, our research and development costs in total, and inthe periods presented, may have been different; our speed to commercializationand resulting sales, if any, may have been different; or our costs tomanufacture may have been different. In addition, our marketing efforts mayhave been received differently by our customers. As such, in total, there canbe no assurance that our Adjusted income amounts would have been the same aspresented had Pfizer discovered and developed the acquired intangible assets.

Merger-Related Costs

Adjusted income is calculatedprior to considering integration and restructuring costs associated withbusiness combinations because these costs are unique to each transaction andrepresent costs that were incurred to restructure and integrate two businessesas a result of the acquisition decision. For additional clarity, only restructuringand integration activities that are associated with a purchase businesscombination or a net-asset acquisition are included in merger-related costs. Wehave not factored in the impacts on synergies that would have resulted hadthese costs not been incurred.

We believe that viewing incomeprior to considering these charges provides investors with a useful additionalperspective because the significant costs incurred in a business combinationresult primarily from the need to eliminate duplicate assets, activities oremployees--a natural result of acquiring a fully integrated set of activities. Forthis reason, we believe that the costs incurred to convert disparate systems,to close duplicative facilities or to eliminate duplicate positions (forexample, in the context of a business combination) can be viewed differentlyfrom those costs incurred in other, more normal business contexts.

The integration andrestructuring costs associated with a business combination may occur overseveral years with the more significant impacts ending within three years ofthe transaction. Because of the need for certain external approvals for some actions,the span of time needed to achieve certain restructuring and integrationactivities can be lengthy. For example, due to the highly regulated nature ofthe pharmaceutical business, the closure of excess facilities can take severalyears as all manufacturing changes are subject to extensive validation and testingand must be approved by the FDA. In other situations, we may be required bylocal laws to obtain approvals prior to terminating certain employees. Thisapproval process can delay the termination action.

Discontinued Operations

Adjusted income is calculatedprior to considering gains or losses on the sale of businesses and productlines included in discontinued operations as well as the related results of operations.We believe that this presentation is meaningful to investors because, while wereview our businesses and product lines on an ongoing basis for strategic fitwith our operations, we do not build or run our businesses with an intent tosell them.

Certain Significant Items

Adjusted income is calculatedprior to considering certain significant items. Certain significant itemsrepresent substantive, unusual items that are evaluated on an individual basis.Such evaluation considers both the quantitative and the qualitative aspect oftheir unusual nature. Unusual, in this context, may represent items that arenot part of our ongoing business; items that, either as a result of theirnature or size, we would not expect to occur as part of our normal business ona regular basis; items that would be non-recurring; or items that relate toproducts we no longer sell. While not all-inclusive, examples of items that couldbe included as certain significant items would be a majornon-acquisition-related restructuring charge and associated implementationcosts for a program which is specific in nature with a defined term, such asthose related to our Adapting to Scale initiative; costs associated with asignificant recall of one of our products; charges related to sales ordisposals of products or facilities that do not qualify as discontinuedoperations as defined by U.S. GAAP; certain intangible asset impairments;adjustments related to the resolution of certain tax positions; the impact ofadopting certain significant, event-driven tax legislation, such as chargesattributable to the repatriation of foreign earnings in accordance with the JobsAct; or possible charges related to legal matters, such as certain of those discussedin *Legal Proceedings*in our Form 10-K and in *Part II: OtherInformation; Item 1, Legal Proceedings*included in our Form 10-Q filings. Normal,ongoing defense costs of the Company or settlements and accruals on legalmatters made in the normal course of our business would not be considered acertain significant item.

Reconciliation

A reconciliation between *Netincome*, as reported under U.S. GAAP, and Adjusted income follows:

Third  Quarter

First  Nine Months

(millions of dollars)

2005 

2004 

%  Incr./  (Decr.)

2005 

2004 

%  Incr./  (Decr.)

  

Reported Net  income

$

1,589 

$

3,341 

(52)%

$

5,352 

$

8,536 

(37)%

Purchase  accounting adjustments - net of tax

1,963 

521 

276    

3,401 

2,558 

33    

Merger-related costs - net  of tax

67 

112 

(40)   

397 

463 

(14)   

Discontinued  operations - net of tax

13 

(43)

*    

(7)

(75)

(91)   

Certain  significant items - net of tax

179 

229 

(22)   

2,092 

269 

678    

Adjusted income

$

3,811 

$

4,160 

(8)   

$

11,235 

$

11,751 

(4)   

  

*

Calculation  not meaningful.

Certain  amounts and percentages may reflect rounding adjustments.

Adjusted income as shown aboveexcludes the following items:

Third  Quarter

First  Nine Months

(millions of dollars)

2005 

2004 

2005 

2004 

  

*Purchase  accounting adjustments, pre-tax:*

In-process  research and development charges(a)

$

1,390 

$

-- 

$

1,652 

$

955 

Intangible  amortization and other(b)

811 

827 

2,494 

2,450 

Total purchase  accounting adjustments, pre-tax

2,201 

827 

4,146 

3,405 

Income taxes

(238)

(306)

(745)

(847)

*Total  purchase accounting adjustments - net of tax*

1,963 

521 

3,401 

2,558 

*Merger-related  costs, pre-tax:*

Integration  costs(c)

93 

113 

390 

367 

Restructuring  costs(c)

61 

77 

232 

359 

Total  merger-related costs, pre-tax

154 

190 

622 

726 

Income taxes

(87)

(78)

(225)

(263)

*Total  merger-related costs - net of tax*

67 

112 

397 

463 

*Discontinued  operations, pre-tax:*

Loss/(income)  from discontinued operations (d)

10 

3 

44 

(42)

Gains on sales  of discontinued operations(d)

(7)

(65)

(72)

(68)

Total  discontinued operations, pre-tax

3 

(62)

(28)

(110)

Income taxes

10 

19 

21 

35 

*Total  discontinued operations - net of tax*

13 

(43)

(7)

(75)

*Certain  significant items, pre-tax*

Asset  impairment charges and other costs associated with the suspension of selling  Bextra(e)

3 

-- 

1,216 

-- 

Litigation-related  charge(f)

-- 

369 

-- 

369 

Operating  results of divested legacy Pharmacia research facility(g)

-- 

-- 

-- 

64 

Restructuring  charges--Adapting to Scale(c)

153 

-- 

174 

-- 

Implementation  costs--Adapting to Scale(h)

104 

-- 

136 

-- 

Total certain  significant items, pre-tax

260 

369 

1,526 

433 

Income taxes

(81)

(140)

(547)

(164)

Resolution of  certain tax positions(i)

-- 

-- 

(586)

-- 

Tax impact of  the repatriation of foreign earnings(i)

-- 

-- 

1,699 

-- 

*Total  certain significant items - net of tax*

179 

229 

2,092 

269 

*Total purchase  accounting adjustments, merger-related costs, discontinued operations and  certain significant items - net of tax*

  $

2,222 

$

819 

$

5,883 

$

3,215 

  

(a)

Included  in *Merger-related in-process research and development charges.*

(b)

Included  primarily in *Amortization of intangible assets.*

(c)

Included  in *Restructuring charges and merger-related costs.*

(d)

Included  in *Discontinued operations - net of tax.*

(e)

Included  in *Selling, informational and administrative expenses* ($3 million)  for the three months ended October 2, 2005, and included in *Cost of  sales* ($56 million), *Selling informational and  administrative expenses* ($8 million) and*Other  (income)/deductions - net*($1.2 billion) for the nine  months ended October 2, 2005.

(f)

Included  in *Other (income)/deductions - net.*

(g)

Included  in *Research and development expenses.*

(h)

Included  in *Cost of sales* ($36 million),*Selling, informational and  administrative expenses* ($60 million), and *Research and  development**expenses* ($8 million) for the three months ended October 2,  2005, and included in *Cost of sales* ($37 million), *Selling,  informational and administrative expenses*($81 million), and *Research  and development expenses* ($18 million) for the nine months ended  October 2, 2005.

(i)

Included  in *Provision for taxes on income.*

FINANCIAL CONDITION, LIQUIDITY AND CAPITAL RESOURCES

Net Financial Asset Position

Our net financial assetposition follows:

(millions  of dollars)

Oct. 2,  2005

Dec. 31,  2004

  

Financial  assets:

Cash and cash  equivalents

$

959

$

1,808

Short-term  investments

12,430

18,085

Short-term  loans

611

653

Long-term  investments and loans

2,784

3,873

Total financial  assets

16,784

24,419

Debt:

Short-term  borrowings

6,729

11,266

Long-term debt

5,414

7,279

Total debt

12,143

18,545

Net financial  assets

$

4,641

$

5,874

We rely largely on operating cash flow, short-termcommercial paper borrowings and long-term debt to provide for the workingcapital needs of our operations, including our R&D activities. In addition,the proceeds from the repatriation of foreign earnings are being utilized tofinance domestic activities over a multi-year time horizon, thereby reducingour reliance on domestic short-term borrowings. Our international borrowingswill increase over the course of 2005 in order to fund the repatriation of foreignearnings. We believe that we have the ability to obtain both short-term andlong-term debt to meet our financing needs for the foreseeable future.

Expected Impact of Repatriation of Foreign Earnings

Based on our decision to repatriate foreign earningstotaling about $36.7 billion in accordance with the Jobs Act, the use ofproceeds includes domestic expenditures relating to advertising and marketingactivities, research and development activities, capital assets and other assetacquisitions and non-executive compensation in accordance with the provisionsof the Jobs Act (as in effect on October 2, 2005). As of October 2,2005, we have completed the repatriation of approximately $23 billion. At October 2,2005, our international subsidiaries held cash and cash equivalents and short-terminvestments totaling in excess of $3 billion. Additionally, ourinternational subsidiaries are expected to generate cash flows during 2005,which, together with third-party borrowings as required, will be available to fundthe balance of the repatriation. 

Investments

Our short-term and long-term investments consist primarilyof high-quality, liquid investment-grade available-for-sale debt securities.Wherever possible, cash management is centralized and intercompany financing isused to provide working capital to our operations. Where local restrictionsprevent intercompany financing, working capital needs are met through operatingcash flows and/or external borrowings.

Debt Capacity

Our short-term borrowings are rated P-1 by Moody's InvestorsService (Moody's) and A-1+ by Standard & Poor's (S&P). Our long-termdebt is rated Aaa by Moody's and AAA by S&P. Moody's and S&P are majorcorporate debt-rating organizations. In early April 2005, following the marketwithdrawal of Bextra and the FDA's decision requiring new labeling forCelebrex, Moody's placed our Aaa rating under review for possible downgrade. Thereview was completed in June 2005 when Moody's removed Pfizer from reviewstatus and reaffirmed our Aaa rating. However, Moody's maintained our ratingoutlook as negative. S&P has reaffirmed our AAA rating and maintains ouroutlook as stable.

Our superior credit ratings are primarily based on ourdiversified product portfolio, our strong operating cash flow, our substantialfinancial assets, our strong late-stage product pipeline and on our desire tomaintain a prudent financial profile. Our access to financing at favorablerates would be affected by a substantial downgrade in our credit ratings.

We have available lines of credit and revolving-creditagreements with a group of banks and other financial intermediaries. Wemaintain cash balances and short-term investments in excess of our commercialpaper and other short-term borrowings. At October 2, 2005, we had accessto $3.0 billion of lines of credit, of which $1.1 billion expirewithin one year. Of these lines of credit, $2.8 billion are unused, ofwhich our lenders have committed to loan us $1.7 billion at our request. $1.5 billionof the unused lines of credit relate to our commercial paper borrowings.

At October 2, 2005, we had the ability to borrowapproximately $2.0 billion by issuing debt securities under our existingdebt shelf registration statement filed in November 2002.

*Long-Term Debt*

In July 2005, we decided to exercise Pfizer's option tocall, at par-value plus accrued interest, $1 billion of senior unsecuredfloating-rate notes, which were included in *Long-term debt* at December31, 2004. Notice to call was given to the Trustees and the notes were redeemedin September 2005.

Goodwill and Other Intangible Assets

At October 2, 2005,goodwill totaled $23.8 billion (21% of our total assets) and other intangibleassets, net of accumulated amortization, totaled $29.0 billion (26% of ourtotal assets). The largest components of goodwill and other intangible assetswere acquired in connection with our acquisition of Pharmacia. Other intangibleassets included $23.0 billion of developed technology rights and $3.9 billionof indefinite-lived brands.

The developed technology rightsprimarily represent the amortized acquisition-date fair value of thecommercialized products that we acquired from Pharmacia. We acquired awell-diversified portfolio of developed technology rights across thetherapeutic categories displayed in the table of major Human Health products inthe "Revenues" section of MD&A. While the Arthritis and Paintherapeutic category represents about 28% of the total value of developedtechnology rights at October 2, 2005, the balance of the value is evenlydistributed across the following Human Health therapeutic product categories:Ophthalmology; Oncology; Urology; Infectious and Respiratory Diseases;Endocrine Disorders categories; and, as a group, the Cardiovascular andMetabolic Diseases; Central Nervous System Disorders and All Other categories.

SELECTED MEASURES OF LIQUIDITY AND CAPITAL RESOURCES

The following table sets forthcertain relevant measures of our liquidity and capital resources:

Oct. 2,  2005

Dec. 31,  2004

  

Cash and cash  equivalents and short-term investments and loans (millions of dollars)

$

14,000

$

20,546

  

Working capital (millions of  dollars)(a)

$

12,373

$

13,236

  

Current ratio(b)

1.61:1

1.50:1

  

Shareholders' equity per common  share(c)

$

9.11

$

9.19

  

(a)

Working  capital includes assets and liabilities held for sale at October 2, 2005  and December 31, 2004.

(b)

Current  ratio is the proportion of current assets to current liabilities.

(c)

Represents  total shareholders' equity divided by the actual number of common shares  outstanding (which excludes treasury shares and those held by our employee  benefit trust).

The decrease in working capitalfrom December 31, 2004 to October 2, 2005 primarily reflects:

•

payment of cash dividends on common  and preferred stock, net of dividends payable at December 31, 2004  -- $2.8 billion;

  

•

purchases of our common stock -- $3.4 billion;

  

•

net cash paid to acquire Vicuron  Pharmaceuticals, Inc. and other smaller businesses -- $2.1 billion;

   

•

payment of floating-rate notes  --$1.0 billion;

  

•

purchases of property, plant and  equipment -- $1.5 billion; and

  

•

purchases of other assets --$392  million,

partially offset by:

•

cash from current-period operations.

Net Cash Provided by Operating Activities

During the first nine months of 2005, net cash provided bycontinuing operating activities was $10.0 billion, as compared to$10.4 billion in the same period of 2004. The decrease in net cashprovided by operating activities was primarily driven by lower current periodincome from operations, net of non-cash items, partially offset by the timingof receipts and payments in the ordinarily course of business. In the cash flowsstatement, *Other* includes adjustments for non-cash items such as valuationadjustments.

Net Cash Provided by/(Used in) Investing Activities

During the first nine months of2005, net cash provided by investing activities was $2.7 billion, comparedto net cash used of $6.7 billion in the same period in 2004. The changefrom net cash used in 2004 to net cash provided by investing activities in 2005was primarily attributable to:

•

net redemptions of $6.3 billion  from investments in 2005 primarily used to provide funds for the repatriation  of foreign earnings in accordance with the Jobs Act compared to net purchases  of $4.6 billion of investments in 2004, 

  

partially offset by:

   

•

proceeds from sales of businesses  and product lines of $108 million in 2005 as compared to $1.2 billion in  2004; and

   

•

net cash used for acquisitions in  2005 of $2.1 billion as compared to $1.4 billion in 2004.

Net Cash Used in Financing Activities

During the first nine months of2005, net cash used in financing activities was $13.5 billion, as comparedto $3.3 billion in the same period in 2004. The increase in net cash usedin financing activities in 2005 was primarily attributable to:

•

net repayments of $6.3 billion  on total borrowings in 2005 (funds from the repatriation of foreign earnings  were used to finance domestic activities, thereby reducing our reliance on  short-term borrowings) as compared to total net borrowings of $4.4 billion  in 2004,

  

•

an increase in cash dividends paid  of $356 million as compared to the first nine months of 2004 due to an  increase in the dividend rate and

  

•

a decrease of $568 million in  the proceeds from the exercise of stock options, 

  

partially offset by:

   

•

a decrease of $1.4 billion in  purchases of our common stock in 2005 as compared to the same period in 2004.

In October 2004, we announced a $5 billionshare-purchase program. We completed this share-purchase program by purchasingapproximately $2.4 billion of the Company's stock in the second quarter of2005. In June 2005, Pfizer's Board of Directors authorized a new $5 billionshare-purchase program. During the third quarter of 2005, we purchased approximately4.3 million shares of common stock at a cost of approximately $111 millionunder the new program. The Company has purchased nearly 126 million sharesof common stock, at a cost of approximately $3.4 billion, during 2005. Weremain committed to completing this newly authorized $5 billionshare-purchase program.

OFF-BALANCE SHEET ARRANGEMENTS

In the ordinary course of business and in connection withthe sale of assets and businesses, we often indemnify our counterpartiesagainst certain liabilities that may arise in connection with a transaction orrelated to activities prior to a transaction. These indemnifications typicallypertain to environmental, tax, employee and/or product-related matters, andpatent infringement claims. If the indemnified party were to make a successfulclaim pursuant to the terms of the indemnification, we would be required toreimburse the loss. These indemnifications are generally subject to thresholdamounts, specified claim periods and other restrictions and limitations.Historically, we have not generally paid significant amounts under theseprovisions and at October 2, 2005, recorded amounts for the estimated fairvalue of these indemnifications are not material.

Certain of our copromotion agreements include additionalprovisions that give our alliance partners the right to negotiate for, or insome cases to obtain, under certain financial conditions, copromotion rights inspecified countries with respect to certain of our products.

RECENTLY ISSUED ACCOUNTING STANDARDS

*Share-Based Payment*

In December 2004, the Financial Accounting Standards Board(FASB) issued Statement of Financial Accounting Standards (SFAS) No. 123R,*Share-Based Payment*. SFAS 123R replaces SFAS 123,*Stock-Based Compensation*. SFAS 123R requires that the fair value ofthe grant of employee stock options be reported as an expense. We plan to adoptSFAS 123R, when required, beginning in the first quarter of 2006. (We hadpreviously disclosed an intention to adopt, when required, in mid-2005, but theSEC delayed the required effective date). Determining the impact of SFAS 123Ron our future results of operations requires a number of complex estimatesabout future events. For example, such an assessment would require a predictionabout the number of options to be granted, primarily in February of next year,and a forecast, as of the grant date, of our stock price, the market-basedstock price volatility and the risk-free interest rate, all of which can behighly variable and difficult to predict. As such, currently, we cannotreasonably estimate the impact of SFAS 123R on our results of operationsin 2006.

*Conditional Asset Retirement Obligations*

In March 2005, the FASB issued Interpretation No. 47, *Accountingfor Conditional Asset Retirement Obligations* (FIN 47). FIN 47clarifies that conditional obligations meet the definition of an assetretirement obligation in SFAS 143, *Accounting for Asset RetirementObligations*, and therefore should be recognized if their fair value isreasonably estimable. We plan to adopt FIN 47 in the fourth quarter of2005. We do not expect the provisions of FIN 47 to have a material impacton our consolidated financial statements.

OUTLOOK

Results in 2005 have been, and will continue to be, impactedby the loss of U.S. exclusivity of four major products--Diflucan, Neurontin,and Accupril/Accuretic during 2004 and Zithromax in November 2005. Revenuesalso have been, and may continue to be, impacted by publicity and regulatoryactions regarding selective COX-2 inhibitors, as well as lower prescriptiongrowth and increased competition in key markets in the U.S., such as thelipid-lowering market and the erectile-dysfunction market. Full-year revenuesare expected to evidence a modest decline relative to 2004, although a somewhatlarger decline than previously anticipated, reflecting lower Human Healthrevenues.

In 2005, we anticipate Pharmacia merger-related synergies ofapproximately $4.2 billion, an increase of $600 million over 2004synergies. We also expect to achieve approximately $600 million in costsavings from our AtS productivity**initiative during 2005, greater thanpreviously forecasted, mainly attributable to the Human Health business.

Given these and other factors, at current exchange rates weexpect 2005 Adjusted income of $14.2 to $14.4 billion, Adjusted dilutedEPS of $1.92 to $1.94, reported Net income of $7.5 to $7.7 billion, andreported diluted EPS of $1.02 to $1.04, subject to the "Cautionary FactorsThat May Affect Future Results" section below. The forecasted Adjusted incomeand diluted EPS ranges, as well as the forecasted reported Net income and dilutedEPS ranges, are subject to a number of factors and uncertainties--changes in prescriptiongrowth rates and increased competition in key therapeutic markets andgeographies; Adapting to Scale restructuring activities; the timing and rate ofcommercial acceptance of new-product launches; changes in the geographic,product, and segment mix of our revenues and income; changes in foreignexchange; the timing of regulatory actions; and other factors. Some of thesefactors and uncertainties may persist over the planning horizon. We arecurrently assessing these factors and other variables as part of our annualplanning process and have withdrawn our previously provided financial guidancefor 2006 and 2007.

A reconciliation of forecasted2005 Adjusted income and Adjusted diluted EPS to forecasted 2005 reported Netincome and reported diluted EPS follows:

($ billions,  except per-share amounts)

Net  Income

Diluted  EPS

   

Forecasted Adjusted income/diluted  EPS

$14.2  - $14.4

$1.92  - $1.94

Intangible amortization and other  

(2.3)       

(.32)      

In-process R&D charges (primarily  Vicuron & Idun)

(1.7)       

(.22)      

Merger-related  costs/productivity-initiative costs

(.9)       

(.13)      

Equity gains

.1        

.02       

Asset-impairment  charges and other costs associated with the suspension of selling Bextra

(.8)       

(.10)      

Tax impact on repatriation of  foreign earnings

(1.7)       

(.23)      

Resolution of certain tax positions

.6        

.08       

Forecasted reported Net  income/diluted EPS

$  7.5  - $  7.7

$1.02  - $1.04

Pfizer's estimates of 2005 reported Net income of approximately$7.5 billion to $7.7 billion and reported diluted earnings per shareof approximately $1.02 to $1.04, have been revised from the prior guidance of$9.1 billion and about $1.24. The revision is principally attributable to in-processR&D charges of $1.4 billion ($0.19 per share) related to theacquisition of Vicuron during the third quarter of 2005 and revisedexpectations (reflective of a lower revenue outlook, partially offset bygreater expected savings associated with the Adapting to Scale productivityinitiative and other expense revisions, and a lower effective tax rate),partially offset by anticipated gains on the sale of equity investments.

We expect to spend about $7.6 billion on research anddevelopment in 2005 and approximately $2.2 billion in capital expendituresfor the full year 2005.

CAUTIONARY FACTORS THAT MAY AFFECT FUTURE RESULTS

Our disclosure and analysis inthis report, including but not limited to the information discussed in theOutlook section above, contain forward-looking information about our Company'sfinancial results and estimates, business prospects and products in researchthat involve substantial risks and uncertainties. From time to time, we alsomay provide oral or written forward-looking statements in other materials werelease to the public. Forward-looking statements give our current expectationsor forecasts of future events. You can identify these statements by the factthat they do not relate strictly to historic or current facts. They use wordssuch as "will," "anticipate," "estimate," "expect,""project," "intend," "plan," "believe,""target," "forecast" and other words and terms of similarmeaning in connection with any discussion of future operating or financialperformance. In particular, these include statements relating to futureactions, prospective products or product approvals, future performance orresults of current and anticipated products, sales efforts, expenses, interestrates, foreign exchange rates, the outcome of contingencies, such as legal proceedings,and financial results. Among the factors that could cause actual results todiffer materially are the following:

•

the success of research and  development activities;

  

•

decisions by regulatory authorities  regarding whether and when to approve our drug applications as well as their  decisions regarding labeling and other matters that could affect the  commercial potential of our products;

  

•

the speed with which regulatory  authorizations, pricing approvals, and product launches may be achieved;

  

•

competitive developments affecting  our current growth products;

  

•

the ability to successfully market  both new and existing products domestically and internationally;

  

•

difficulties or delays in  manufacturing;

  

•

trade buying patterns;

  

•

the ability to meet generic and  branded competition after the loss of patent protection for our products;

  

•

the impact of existing and future  regulatory provisions on product exclusivity;

  

•

trends toward managed care and healthcare  cost containment;

  

•

possible U.S. legislation or  regulatory action affecting, among other things, pharmaceutical pricing and  reimbursement, including under Medicaid and Medicare, the importation of  prescription drugs that are marketed outside the U.S. and sold at prices that  are regulated by governments of various foreign countries, and the involuntary  approval of prescription medicines for over-the-counter use;

  

•

the potential impact of the  Medicare Prescription Drug, Improvement and Modernization Act of 2003;

  

•

legislation or regulations in  markets outside the U.S. affecting product pricing, reimbursement or access;

  

•

contingencies related to actual or  alleged environmental contamination;

  

•

claims and concerns that may arise  regarding the safety or efficacy of in-line products and product candidates;

  

•

legal defense costs, insurance  expenses, settlement costs and the risk of an adverse decision or settlement  related to product liability, patent protection, governmental investigations,  ongoing efforts to explore various means for resolving asbestos litigation  and other legal proceedings;

   

•

the Company's ability to protect  its patents and other intellectual property both domestically and  internationally;

  

•

interest rate and foreign currency  exchange rate fluctuations;

  

•

governmental laws and regulations  affecting domestic and foreign operations, including tax obligations;

  

•

changes in U.S. generally accepted  accounting principles;

   

•

any changes in business, political  and economic conditions due to the threat of future terrorist activity in the  U.S. and other parts of the world, and related U.S. military action overseas;

  

•

growth in costs and expenses;

  

•

changes in our product mix; and

  

•

the impact of acquisitions,  divestitures, restructurings, product withdrawals and other unusual items,  including our ability to integrate and to obtain the anticipated results and  synergies from our acquisition of Pharmacia, and our ability to realize the  projected benefits of our Adapting to Scale multi-year productivity  initiative.

We cannot guarantee that any forward-looking statement willbe realized, although we believe we have been prudent in our plans andassumptions. Achievement of future results is subject to risks, uncertaintiesand inaccurate assumptions. Should known or unknown risks or uncertaintiesmaterialize, or should underlying assumptions prove inaccurate, actual resultscould vary materially from past results and those anticipated, estimated orprojected. Investors should bear this in mind as they consider forward-lookingstatements.

We undertake no obligation to publicly updateforward-looking statements, whether as a result of new information, futureevents or otherwise. You are advised, however, to consult any furtherdisclosures we make on related subjects in our Forms 10-Q, 8-K and 10-K reportsto the Securities and Exchange Commission. Our Form 10-K filing for the 2004fiscal year listed various important factors that could cause actual results todiffer materially from expected and historic results. We note these factors forinvestors as permitted by the Private Securities Litigation Reform Act of 1995.Readers can find them in Item 1 of that filing under the heading "CautionaryFactors That May Affect Future Results." We incorporate that section ofthat Form 10-K in this filing and investors should refer to it. You shouldunderstand that it is not possible to predict or identify all such factors.Consequently, you should not consider any such list to be a complete set of allpotential risks or uncertainties.

This report includes discussion of certain clinical studiesrelating to various in-line products and/or product candidates. These studiestypically are part of a larger body of clinical data relating to such productsor product candidates, and the discussion herein should be considered in thecontext of the larger body of data. 

Legal Proceedings and Contingencies

We and certain of our subsidiaries are involved in variouspatent, product liability, consumer, commercial, securities, environmental andtax litigations and claims; government investigations; and other legalproceedings that arise from time to time in the ordinary course of ourbusiness. We do not believe any of them will have a material adverse effect onour financial position.

We record accruals for such contingencies to the extent thatwe conclude their occurrence is probable and the related damages are estimable.If a range of liability is probable and estimable and some amount within therange appears to be a better estimate than any other amount within the range,we accrue that amount. If a range of liability is probable and estimable and noamount within the range appears to be a better estimate than any other amountwithin the range, we accrue the minimum of such probable range. Many claimsinvolve highly complex issues relating to causation, label warnings, scientificevidence, actual damages and other matters. Often these issues are subject to substantialuncertainties and, therefore, the probability of loss and an estimation ofdamages are difficult to ascertain. Consequently, we cannot reasonably estimatethe maximum potential exposure or the range of possible loss in excess ofamounts accrued for these contingencies. These assessments can involve a seriesof complex judgments about future events and can rely heavily on estimates andassumptions. Our assessments are based on estimates and assumptions that havebeen deemed reasonable by management. Litigation is inherently unpredictable,and excessive verdicts do occur. Although we believe we have substantialdefenses in these matters, we could in the future incur judgments or enter intosettlements of claims that could have a material adverse effect on our resultsof operations in any particular period. 

Patent claims include challenges to the coverage and/orvalidity of our patents on various products or processes. Although we believewe have substantial defenses to these challenges with respect to all ourmaterial patents, there can be no assurance as to the outcome of these matters,and a loss in any of these cases could result in a loss of patent protectionfor the drug at issue, which could lead to a significant loss of sales of thatdrug and could materially affect future results of operations.

Item 4.  Controls and Procedures.

As of the end of the period covered by this report, wecarried out an evaluation, under the supervision and with the participation ofour principal executive officer and principal financial officer, of theeffectiveness of the design and operation of our disclosure controls andprocedures (as such term is defined in Rules 13a-15(e) and 15d-15(e) under theSecurities Exchange Act of 1934 (the Exchange Act)). Based on this evaluation,our principal executive officer and principal financial officer concluded thatour disclosure controls and procedures are effective in alerting them in atimely manner to material information required to be disclosed in our periodicreports filed with the SEC.

During our most recent fiscalquarter, there has not occurred any change in our internal control overfinancial reporting (as such term is defined in Rules 13a-15(f) and 15d-15(f)under the Exchange Act) that has materially affected, or is reasonably likelyto materially affect, our internal control over financial reporting.

**PART II - OTHERINFORMATION**

Item 1.  Legal Proceedings.

Certain legal proceedings in which we are involved arediscussed in Note 17 to the consolidated financial statements included in our2004 Financial Report; Part I, Item 3, of our Annual Report on Form10-K for the year ended December 31, 2004; and Part II, Item 1, of ourQuarterly Reports on Form 10-Q for the quarters ended April 3 and July 3, 2005.The following discussion is limited to recent developments concerning our legalproceedings and should be read in conjunction with those earlier Reports.Unless otherwise indicated, all proceedings discussed in those earlier Reportsremain outstanding. Reference also is made to the Legal Proceedings andContingencies section in Part I, Item 2, of this Form 10-Q.

**Patent Matters**

Lipitor (atorvastatin)

As previously reported, our patent rights to Lipitor arebeing challenged in various countries. On October 12, 2005, in an actionbrought by generic manufacturer Ranbaxy Ltd., the United Kingdom's High Courtof Justice upheld our basic U.K. patent for Lipitor, which expires in 2011, butruled that a second patent covering the calcium salt of atorvastatin, whichexpires in 2010, is invalid. Both sides intend to appeal the decision. Ifupheld on appeal, the decision will prohibit Ranbaxy from introducing a genericversion of atorvastatin in the U.K. before the expiration of our basic patentin 2011.

The trial of our Lipitor patent-infringement action againstRanbaxy in the U.S. District Court for the District of Delaware was held inlate 2004. While a decision is possible later this year, the court has notindicated when it intends to issue its judgment.

Neurontin (gabapentin)

As previously reported, in 2000, 2001 and 2003,Warner-Lambert brought patent infringement suits in various federal courtsagainst several generic manufacturers that had filed abbreviated new drugapplications with the FDA asserting the invalidity and non-infringement of ourgabapentin (Neurontin) low-lactam patent. These suits were consolidated forpre-trial purposes in the U.S. District Court for the District of New Jersey.The defendant generic manufacturers filed various summary judgment motionsasserting invalidity and non-infringement on a number of grounds. In August2005, the court, while denying eight of the ten summary judgment motions,granted two motions for summary judgment of non-infringement. It is expectedthat both sides will appeal the decision. 

Neurontin has faced generic competition in the U.S. sincelast year. The FDA granted approval to a number of manufacturers for theirgeneric gabapentin products, and the manufacturers began to market thoseproducts, in 2004.

Xalatan (lantanoprost)

As previously reported, in November 2001, a genericmanufacturer notified Pharmacia that it had filed an abbreviated new drugapplication with the FDA seeking approval to market a product containinglatanoprost, which Pharmacia markets as Xalatan. In December 2001, Pharmaciafiled suit against the generic manufacturer in the U.S. District Court for theDistrict of New Jersey alleging infringement of various patents relating tolatanoprost that are held by or licensed to Pharmacia. The generic manufactureradmitted infringement but claimed that these patents are invalid andunenforceable. 

In July 2004, the court held that two of the three patentsin suit are valid, infringed and enforceable, and it issued an injunctionblocking sale of the generic product until the expiration of the later-expiringpatent in March 2011. The generic manufacturer appealed the decision withrespect to these two patents. The third patent, which also expires in March2011, was held unenforceable. We appealed the decision with respect to thethird patent. In July 2005, the U.S. Court of Appeals for the Federal Circuitaffirmed the District Court's decision as to all three patents, therebyblocking sale of the generic product until March 2011. In October 2005, theFederal Circuit denied the generic manufacturer's request for an en banc reviewof the three-member panel decision.

**Product Liability Matters**

Rezulin

As previously reported, in April 2001, Louisiana HealthService Indemnity Company and Eastern States Health and Welfare Fund filed aconsolidated complaint against Warner-Lambert in the U.S. District Court forthe Southern District of New York purportedly on behalf of a class consistingof all health benefit providers that paid for or reimbursed patients for thepurchase of Rezulin between February 1997 and April 2001. In September 2005,the court granted Warner-Lambert's motion for summary judgment and dismissedthe complaint. In November 2005, the plaintiffs appealed the decision.

Viagra

A number of lawsuits, including purported class actions,have been filed against us in various federal and state courts alleging thatViagra causes certain types of visual injuries. The plaintiffs in the purportedclass actions seek to represent nationwide and certain statewide classes ofViagra users. All of the actions seek damages for personal injury, and thepurported class actions also seek medical monitoring.

**Commercial Matters**

Lipitor

Beginning in September 2005, a number of purported classactions have been filed against us in various federal courts alleging claimsrelating to the promotion of Lipitor. In each of the actions, the plaintiffsseek to represent a nationwide class consisting of women (regardless of age)and men over age 65 who in each case had no history of heart disease or diabetesand who purchased Lipitor within the last four years. In certain of theactions, the plaintiffs also seek to represent health insurers, employeebenefit plans and other third-party payors that paid for Lipitor used byindividuals in either of the aforementioned two groups. The plaintiffs in theseactions allege that the Company engaged in false and misleading advertising inviolation of state consumer protection laws by allegedly promoting Lipitor forthe prevention of heart disease in the aforementioned two groups. The actionsseek monetary and injunctive relief, including treble damages. In addition, apurported class action on behalf of residents of the Province of Quebec hasbeen filed against us in Canada that asserts claims under Canadian law and seeksrelief substantially similar to the claims asserted and the relief sought inthe U.S. actions. 

**Celebrex and Bextra**

As previously reported, the Company is a defendant in anumber of product liability, consumer fraud, securities, fiduciary duty andERISA (Employee Retirement Income Security Act of 1974) actions, includingpurported class and derivative actions, relating to Celebrex and Bextra.Certain current and former officers, directors and employees of Pfizer andPharmacia also are named as defendants in some of those actions. In June 2005,the federal securities, fiduciary duty and ERISA actions were transferred tothe U.S. District Court for the Southern District of New York for consolidatedpre-trial proceedings. In September 2005, the federal product liability andconsumer fraud actions were transferred to the U.S. District Court for theNorthern District of California for consolidated pre-trial proceedings. 

**Other Matters**

The Department of Justice

The U.S. Department of Justice has informed us that it isinvestigating Pharmacia's former contractual relationship with a health careintermediary. 

We have received requests for information and documents fromthe U.S. Department of Justice relating to certain physician payments budgetedto our prescription pharmaceutical products.

Importation Cases

As previously reported, in 2004 a number of purported classactions were filed in the U.S. District Court for the District of Minnesotaalleging that Pfizer and several other pharmaceutical manufacturers violatedfederal and state civil antitrust laws by conspiring to prevent the importationof brand-name prescription drugs from Canada. These suits all were consolidatedinto a single action, which sought to represent a nationwide class consistingof all persons who purchased or reimbursed patients for the purchase ofprescription drugs manufactured and marketed by defendants that also areavailable in Canada. In August 2005, the court granted the defendants' motionto dismiss this action, and the plaintiffs have appealed the decision. Thepreviously reported California state court action by a number of independentpharmacists in California that asserts similar claims under Californiaantitrust and unfair business practices laws is still pending. The defendants'motion to dismiss the California action was partially granted and partiallydenied in July 2005. 

Environmental Matters

As previously reported, in July 2005, the U.S. EnvironmentalProtection Agency (EPA) proposed a civil penalty in the amount of $275,000 to settlecertain alleged violations of the Federal Clean Air Act at our Kalamazoo,Michigan facility that were identified by the EPA during an inspection in 2004.In September 2005, this matter was resolved pursuant to a settlement thatprovides for a $47,250 civil penalty and a commitment to undertake twosupplemental environmental projects at the facility. Corrective actions havebeen implemented.

**Tax Matters**

In the second quarter of 2005, we recorded a tax benefit of$586 million primarily related to the resolution of certain tax positions.In addition, we believe that the IRS audits of the Pfizer Inc. tax returns forthe years 1999-2001 and the Warner-Lambert Company tax returns for the years1999 through the date of the merger with Pfizer (June 19, 2000) aresubstantially complete. In connection with those audits, we are currently inthe process of appealing one matter related to the tax deductibility of abreakup fee paid by Warner-Lambert Company in 2000.

The IRS has commenced the audit of the Pfizer Inc. tax returnsfor the years 2002, 2003 and 2004. The 2005 tax year is also currently underaudit as we are voluntary participants in the IRS Compliance Assurance Program,which results in real-time tax audits.

As previously disclosed, with respect to PharmaciaCorporation (formerly known as Monsanto Company), the IRS has completed andclosed its income tax return examinations and appeals through 1999 and hascommenced the audit of the tax returns for the years 2000 through the date ofmerger with Pfizer (April 16, 2003).

We periodically reassess the likelihood of assessmentsresulting from audits of federal, state and foreign income tax filings. Webelieve that our accruals for tax liabilities are adequate for all open years.

Item 2.  Unregistered Sales of Equity Securitiesand Use of Proceeds.

This table provides certain information with respect toour purchases of shares of Pfizer's common stock during the fiscal thirdquarter of 2005:

Issuer Purchases of Equity  Securities(a)

  

Period

Total  Number of     Shares Purchased(b)

Average  Price     Paid per Share(b)

Total  Number of    Shares Purchased as    Part of Publicly    Announced Plan(a)

Approximate  Dollar     Value of Shares that     May Yet Be Purchased     Under the Plan(a)

July 4, 2005 through July 31,  2005

24,708   

$26.64   

---   

$5,000,000,000

August 1, 2005 through August 31,  2005

1,642,722   

$25.28   

1,584,100   

$4,960,003,230

September 1, 2005 through  October 2, 2005

2,814,503   

$25.63   

2,755,400   

$4,889,364,758

Total

4,481,933   

$25.51   

4,339,500   

  

(a)

On June 23, 2005, Pfizer  announced that the Board of Directors authorized a $5 billion  share-purchase plan (the "2005 Stock Purchase Plan").

 

    

(b)

In addition to purchases under the  2005 Stock Purchase Plan, this column reflects the following transactions  during the fiscal third quarter of 2005: (i) the deemed surrender to Pfizer  of 79,419 shares of common stock to pay the exercise price and to  satisfy tax withholding obligations in connection with the exercise of  employee stock options, (ii) the open-market purchase by the  trustee of 57,434 shares of common stock in connection with the  reinvestment of dividends paid on common stock held in trust for employees  who were granted performance-contingent share awards and who deferred receipt  of such awards and (iii) the surrender to Pfizer of 5,580 shares of  common stock to satisfy tax withholding obligations in connection with the  vesting of restricted stock issued to employees.

   

   

Item 6.

Exhibits.

  

1)  Exhibit 12

-

Computation of Ratio of Earnings to  Fixed Charges

  

2)  Exhibit 15

-

Accountants' Acknowledgment

  

3)  Exhibit 31.1

-

Certification by the Chief  Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of  2002

  

4)  Exhibit 31.2

-

Certification by the Chief  Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of  2002

  

5)  Exhibit 32.1

-

Certification by the Chief  Executive Officer Pursuant to 18 U.S.C. Section 1350, as Adopted Pursuant to  Section 906 of the Sarbanes-Oxley Act of 2002

  

6)  Exhibit 32.2

-

Certification by the Chief  Financial Officer Pursuant to 18 U.S.C. Section 1350, as Adopted Pursuant to  Section 906 of the Sarbanes-Oxley Act of 2002

PFIZER INC. ANDSUBSIDIARY COMPANIES

SIGNATURE

Under the requirements of theSecurities Exchange Act of 1934, this report was signed on behalf of theRegistrant by the authorized person named below.

Pfizer  Inc.

(Registrant)

  

  

Dated:  November 9,  2005

/s/ Loretta  V. Cangialosi

  

Loretta  V. Cangialosi, Vice President, Controller  (Principal Accounting Officer and  Duly Authorized Officer)

Exhibit 12

PFIZERINC. AND SUBSIDIARY COMPANIESCOMPUTATION OF RATIO OF EARNINGS TO FIXED CHARGES

Nine  Months  Ended  Oct. 2,

Year  Ended December 31,

(in millions, except ratios)

2005

  

2004

2003

2002

2001

2000

  

Determination  of earnings:

Income from  continuing operations before provision for taxes on income, minority  interests and cumulative effect of change in accounting principles

$

8,169

$

14,007

$

3,246

$

11,766

$

9,963

$

5,471

Less:

Minority  interests

9

10

3

6

14

13

Adjusted income

8,160

13,997

3,243

11,760

9,949

5,458

Fixed charges

471

510

442

322

305

444

Total earnings  as defined

$

8,631

$

14,507

$

3,685

$

12,082

$

10,254

$

5,902

  

Fixed charges:

Interest  expense (a)

$

347

$

347

$

270

$

251

$

266

$

381

Preferred stock  dividends (b)

11

12

10

--

--

--

Rents  (c)

113

151

162

71

39

63

Fixed charges

471

510

442

322

305

444

  

Capitalized  interest

12

12

20

28

56

46

  

Total fixed  charges

$

483

$

522

$

462

$

350

$

361

$

490

  

Ratio of  earnings to fixed charges

17.9

27.8

8.0

34.5

28.4

12.0

All financial informationreflects, as applicable, the following businesses and product lines asdiscontinued operations: our in-vitro allergy and autoimmune diagnosticstesting, surgical ophthalmic, certain European generic pharmaceutical, confectionery,shaving and fish-care products businesses, certain non-core consumer healthcareproducts lines (primarily marketed in Europe) and the Estrostep, Loestrin andfemhrt women's health product lines.

Historical ratios of earningsto fixed charges reflect revisions to historical period's rent expense, theimpact of which was not significant to any period.

(a)

Interest expense includes  amortization of debt premium, discount and expenses.

  

(b)

Preferred stock dividends are from  our Series A convertible perpetual preferred stock held by an Employee  Stock Ownership Plan assumed in connection with our acquisition of Pharmacia.

  

(c)

Rents included in the computation  consist of one-third of rental expense which we believe to be a conservative  estimate of an interest factor in our leases, which are not material.

Exhibit 15

ACCOUNTANTS'ACKNOWLEDGMENT

To the Shareholders and Board of Directors of Pfizer Inc:

We hereby acknowledge our awareness of the incorporation byreference of our report dated November 9, 2005, included within theQuarterly Report on Form 10-Q of Pfizer Inc. for the quarter ended October 2,2005, in the following Registration Statements:

- Form S-8 dated October 27, 1983 (File No. 2-87473),

- Form S-8 dated March 22, 1990 (FileNo. 33-34139),

- Form S-8 dated January 24, 1991(File No. 33-38708),

- Form S-8 dated November 18, 1991(File No. 33-44053),

- Form S-8 dated May 27, 1993 (FileNo. 33-49631),

- Form S-8 dated May 19, 1994 (FileNo. 33-53713),

- Form S-8 dated October 5, 1994(File No. 33-55771),

- Form S-8 dated December 20, 1994(File No. 33-56979),

- Form S-8 dated March 29, 1996 (FileNo. 333-02061),

- Form S-8 dated September 25, 1997(File No. 333-36371),

- Form S-8 dated April 24, 1998 (FileNo. 333-50899), 

- Form S-8 dated April 22, 1999 (FileNo. 333-76839), 

- Form S-8 dated June 19, 2000 (FileNo. 333-90975),

- Form S-8 dated June 19, 2000 (FileNo. 333-39606),

- Form S-8 dated June 19, 2000 (FileNo. 333-39610),

- Form S-3 dated October 20, 2000(File No. 333-48382),

- Form S-8 dated April 27, 2001 (FileNo. 333-59660), 

- Form S-8 dated April 27, 2001 (FileNo. 333-59654),

- Form S-3 dated October 30, 2002(File No. 333-100853),

- Form S-3 dated December 16, 2002(File No. 33-56435),

- Form S-8 dated April 16, 2003 (FileNo. 333-104581),

- Form S-8 dated April 16, 2003 (FileNo. 333-104582),

- Form S-8 dated November 18, 2003(File No. 333-110571),

- Form S-8 dated December 18, 2003(File No. 333-111333), 

- Form S-8 dated April 26, 2004 (FileNo.333-114852), and

- Form S-3 dated March 1, 2005 (FileNo. 333-123058).

Pursuant to Rule 436(c) under the Securities Act of 1933,such report is not considered a part of a registration statement prepared orcertified by an accountant or a report prepared or certified by an accountantwithin the meaning of Sections 7 and 11 of that Act.

KPMG LLP

New York, New YorkNovember 9, 2005

**Exhibit 31.1**

**CERTIFICATIONBY THE CHIEF EXECUTIVE OFFICER PURSUANT TOSECTION 302 OF THE SARBANES-OXLEY ACT OF 2002**

I, Henry A. McKinnell, certifythat:

1.

I have reviewed this report on Form  10-Q of Pfizer Inc.;

  

2.

Based on my knowledge, this report  does not contain any untrue statement of a material fact or omit to state a  material fact necessary to make the statements made, in light of the  circumstances under which such statements were made, not misleading with  respect to the period covered by this report;

  

3.

Based on my knowledge, the  financial statements, and other financial information included in this report,  fairly present in all material respects the financial condition, results of  operations and cash flows of the registrant as of, and for, the periods  presented in this report;

  

4.

The registrant's other certifying  officer and I are responsible for establishing and maintaining disclosure  controls and procedures (as defined in Exchange Act Rules 13a-15(e) and  15d-15(e)) and internal control over financial reporting (as defined in  Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

  

a)

Designed such disclosure controls  and procedures, or caused such disclosure controls and procedures to be  designed under our supervision, to ensure that material information relating  to the registrant, including its consolidated subsidiaries, is made known to  us by others within those entities, particularly during the period in which  this report is being prepared;

  

b)

Designed such internal control over  financial reporting, or caused such internal control over financial reporting  to be designed under our supervision, to provide reasonable assurance  regarding the reliability of financial reporting and the preparation of  financial statements for external purposes in accordance with generally  accepted accounting principles;

  

c)

Evaluated the effectiveness of the  registrant's disclosure controls and procedures and presented in this report  our conclusions about the effectiveness of the disclosure controls and  procedures, as of the end of the period covered by this report based on such  evaluation; and

  

d)

Disclosed in this report any change  in the registrant's internal control over financial reporting that occurred  during the registrant's most recent fiscal quarter that has materially  affected, or is reasonably likely to materially affect, the registrant's  internal control over financial reporting; and

  

5.

The registrant's other certifying  officer and I have disclosed, based on our most recent evaluation of internal  control over financial reporting, to the registrant's auditors and the audit  committee of the registrant's board of directors (or persons performing the  equivalent functions):

  

a)

All significant deficiencies and  material weaknesses in the design or operation of internal control over  financial reporting which are reasonably likely to adversely affect the  registrant's ability to record, process, summarize and report financial  information; and

  

b)

Any fraud, whether or not material,  that involves management or other employees who have a significant role in  the registrant's internal control over financial reporting.

Date:  November 9, 2005

  

/s/ Henry A. McKinnell

Henry A. McKinnell  Chairman of the Board and Chief Executive Officer

**Exhibit 31.2**

**CERTIFICATION BYTHE CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002**

I, Alan G. Levin, certify that:

1.

I have reviewed this report on Form  10-Q of Pfizer Inc.;

  

2.

Based on my knowledge, this report  does not contain any untrue statement of a material fact or omit to state a  material fact necessary to make the statements made, in light of the  circumstances under which such statements were made, not misleading with  respect to the period covered by this report;

  

3.

Based on my knowledge, the  financial statements, and other financial information included in this  report, fairly present in all material respects the financial condition,  results of operations and cash flows of the registrant as of, and for, the  periods presented in this report;

  

4.

The registrant's other certifying officer  and I are responsible for establishing and maintaining disclosure controls  and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and  internal control over financial reporting (as defined in Exchange Act Rules  13a-15(f) and 15d-15(f)) for the registrant and have:

  

a)

Designed such disclosure controls  and procedures, or caused such disclosure controls and procedures to be  designed under our supervision, to ensure that material information relating  to the registrant, including its consolidated subsidiaries, is made known to  us by others within those entities, particularly during the period in which  this report is being prepared;

  

b)

Designed such internal control over  financial reporting, or caused such internal control over financial reporting  to be designed under our supervision, to provide reasonable assurance  regarding the reliability of financial reporting and the preparation of  financial statements for external purposes in accordance with generally  accepted accounting principles;

  

c)

Evaluated the effectiveness of the  registrant's disclosure controls and procedures and presented in this report  our conclusions about the effectiveness of the disclosure controls and  procedures, as of the end of the period covered by this report based on such  evaluation; and

  

d)

Disclosed in this report any change  in the registrant's internal control over financial reporting that occurred  during the registrant's most recent fiscal quarter that has materially  affected, or is reasonably likely to materially affect, the registrant's  internal control over financial reporting; and

  

5.

The registrant's other certifying  officer and I have disclosed, based on our most recent evaluation of internal  control over financial reporting, to the registrant's auditors and the audit  committee of the registrant's board of directors (or persons performing the  equivalent functions):

  

a)

All significant deficiencies and  material weaknesses in the design or operation of internal control over  financial reporting which are reasonably likely to adversely affect the  registrant's ability to record, process, summarize and report financial  information; and

  

b)

Any fraud, whether or not material,  that involves management or other employees who have a significant role in  the registrant's internal control over financial reporting.

Date:  November 9, 2005

  

/s/ Alan G. Levin

Alan G. Levin  Senior Vice President and Chief Financial Officer

**Exhibit 32.1**

**Certification bythe Chief Executive Officer Pursuant to 18 U. S. C. Section 1350, as AdoptedPursuant to Section 906 of the Sarbanes-Oxley Act of 2002**

Pursuant to 18 U. S. C. Section 1350, I, Henry A. McKinnell,hereby certify that, to the best of my knowledge, the Quarterly Report ofPfizer Inc. on Form 10-Q for the quarter ended October 2, 2005 (the "Report")fully complies with the requirements of Section 13(a) or Section 15(d) of theSecurities Exchange Act of 1934, and that the information contained in thatReport fairly presents, in all material respects, the financial condition andresults of operations of Pfizer Inc.

  

/s/ Henry A.McKinnell             Henry A. McKinnellChairman of the Board and Chief Executive OfficerNovember 9, 2005

This certification accompanies this Report on Form 10-Qpursuant to Section 906 of the Sarbanes-Oxley Act of 2002 and shall not, exceptto the extent required by such Act, be deemed filed by the Company for purposesof Section 18 of the Securities Exchange Act of 1934, as amended (the "ExchangeAct"). Such certification will not be deemed to be incorporated byreference into any filing under the Securities Act of 1933, as amended, or theExchange Act, except to the extent that the Company specifically incorporatesit by reference.

**Exhibit 32.2**

**Certification bythe Chief Financial Officer Pursuant to 18 U. S. C. Section 1350, as AdoptedPursuant to Section 906 of the Sarbanes-Oxley Act of 2002**

Pursuant to 18 U. S. C. Section 1350, I, Alan G. Levin,hereby certify that, to the best of my knowledge, the Quarterly Report ofPfizer Inc. on Form 10-Q for the quarter ended October 2, 2005 (the "Report")fully complies with the requirements of Section 13(a) or Section 15(d) of theSecurities Exchange Act of 1934, and that the information contained in thatReport fairly presents, in all material respects, the financial condition andresults of operations of Pfizer Inc. 

/s/ Alan G. Levin            Alan G. LevinSenior Vice President and Chief Financial OfficerNovember 9, 2005

This certification accompanies this Report on Form 10-Qpursuant to Section 906 of the Sarbanes-Oxley Act of 2002 and shall not, exceptto the extent required by such Act, be deemed filed by the Company for purposesof Section 18 of the Securities Exchange Act of 1934, as amended (the "ExchangeAct"). Such certification will not be deemed to be incorporated byreference into any filing under the Securities Act of 1933, as amended, or theExchange Act, except to the extent that the Company specifically incorporatesit by reference. |