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**UNITED STATESSECURITIES AND EXCHANGE COMMISSION****WASHINGTON, D.C. 20549**

**FORM 10-Q**

(Mark One)

|   |        | Quarterly report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934. |
|--------|--------|------------------------------------------------------------------------------------------|
|   |   | For the quarterly period ended    September 30, 2005.                                    |

or

|   |  | Transition report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 |
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|   |   | For the transitional period from    __________________ to__________________ |
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|   |   | Commission file number  0-29100 |
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|                                |   |   |
|-------------------------------------|--------|--------|
|  **eResearchTechnology, Inc.** |

|  (Exact name of registrant as specified in its charter) |
|--------------------------------------------------------------|

|                                                          |                                 |
|---------------------------------------------------------------|--------------------------------------|
| Delaware                                                      | 22-3264604                           |
|                                                               |                                      |
| (State or other jurisdiction of incorporation                 | (I.R.S. Employer Identification No.) |
| or organization)                                              |                                 |
|                                                          |                                 |
| 30    South 17th Street                                       |                                 |
| Philadelphia, PA                                              | 19103                                |
|                                                               |                                      |
| (Address of principal executive    offices)                   | (Zip Code)                           |
|                                                          |                                 |
| 215-972-0420                                                  |
|                                                               |
| (Registrant’s telephone    number, including area code) |
|                                                          |                                 |
|                                                          |
|                                                               |
| (Former name, former    address and former fiscal year,       |
| if changed since last report)                                 |

Indicate by check mark whether the    registrant (1) has filed all reports required to be filed by Section 13 or    15(d) of the Securities Exchange Act of 1934 during the preceding 12 months    (or for such shorter period that the registrant was required to file such    reports), and (2) has been subject to such filing requirements for the past    90 days.  

 Yes           No

Indicate by check mark whether the registrant is an accelerated filer (as defined in Rule 12b-2 of the Act).

 Yes       No

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act)

 Yes       No

Indicate the number of shares outstanding of each of the issuer’s classes of common stock, as of the latest practicable date.

The number of shares of Common Stock, $.01 par value, outstanding as of October 31, 2005, was 50,005,224.

 

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eResearchTechnology, Inc. and Subsidiaries

INDEX

|                              |                  |   | Page                                                                                |
|-----------------------------------|-----------------------|--------|-------------------------------------------------------------------------------------|
| Part I.                           | Financial Information |   |                                                                                |
|                              |                  |   |                                                                                |   |   |
|                              | Item 1.               |   | Consolidated Financial Statements                                                   |   |   |
|                              |                  |   |                                                                                |   |   |
|                              |                  |   | Consolidated Balance Sheets-December 31, 2004 and September 30, 2005 (unaudited)    |   | 3 |
|                              |                  |   |                                                                                |   |   |
|                              |                  |   | Consolidated Statements    of Operations (unaudited)–Three and Nine Months     |   |   |
|                              |                  |   | Ended September 30, 2004 and 2005                                                   |   | 4 |
|                              |                  |   |                                                                                |   |   |
|                              |                  |   | Consolidated Statements    of Cash Flows (unaudited)–Nine Months               |   |   |
|                              |                  |   | Ended September 30, 2004 and 2005                                                   |   | 5 |
|                              |                  |   |                                                                                |   |   |
|                              |                  |   | Notes to Consolidated    Financial Statements (unaudited)                           |   | 6-11 |
|                              |                  |   |                                                                                |   |   |
|                              | Item 2.               |   | Management’s    Discussion and Analysis of Financial Condition and Results of |   |   |
|                              |                  |   | Operations                                                                          |   | 12-23 |
|                              |                  |   |                                                                                |   |   |
|                              | Item 3.               |   | Quantitative and    Qualitative Disclosures about Market Risk                       |   | 24 |
|                              |                  |   |                                                                                |   |   |
|                              | Item 4.               |   | Controls and Procedures                                                             |   | 24 |
|                              |                  |   |                                                                                |   |   |
| Part        II. Other Information |                  |   |
|                              |                  |   |                                                                                |   |   |
|                              | Item 2.               |   | Unregistered Sales    of Equity Securities and Use of Proceeds                      |   | 25 |
|                              |                  |   |                                                                                |   |   |
|                              | Item 6.               |   | Exhibits                                                                            |   | 26 |
|                              |                  |   |                                                                                |   |   |
| Signatures                        |                  |   |                                                                                |   | 27 |
|                              |                  |   |                                                                                |   |   |
| Exhibit Index                |                  |   |                                                                                |   | 28 |
|                              |                  |   |                                                                                |   |   |

2

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Back to Contents

**Part 1. Financial Information****Item 1. Consolidated Financial Statements**

eResearchTechnology, Inc. and SubsidiariesConsolidated Balance Sheets(In thousands, except share and per share amounts)

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                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |   | December 31, 2004 |   | September 30, 2005 |   |
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                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             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                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        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| Current Assets:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 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      |   |   |   |
| Cash and cash equivalents $               45,806  $               37,838  Short-term investments                 22,942                  33,984  Accounts receivable, net                 14,798                  11,632  Prepaid expenses and other                   3,522                    5,340  Deferred income taxes                     323                      323      Total current assets                 87,391                  89,117          Property and equipment, net                 25,204                  27,081  Goodwill                   1,212                    1,212  Other assets                      782                    1,100  Deferred income taxes                  1,936                      716      Total assets $             116,525  $             119,226      **Liabilities and Stockholders’ Equity**       Current Liabilities:       Accounts payable $                 2,455  $                 3,097  Accrued expenses                   4,318                    4,619  Income taxes payable                   2,147                    1,106  Current portion of capital lease obligations                      233                       142  Deferred revenues                20,325                 20,730      Total current liabilities                 29,478                 29,694      Capital lease obligations, excluding current portion                     193                        88      Commitments and contingencies               Stockholders’ Equity:       Preferred stock – $10.00 par    value, 500,000 shares authorized,       none issued and outstanding   —  — Common stock – $.01 par value, 175,000,000 shares authorized,       56,396,696 and 56,751,843 shares issued, respectively                      564                       568  Additional paid-in capital                 69,694                  72,369  Accumulated other comprehensive income                   1,601                       868  Retained earnings                 46,550                  56,615  Treasury stock, 6,067,519 and 6,747,119 shares       at cost, respectively              (31,555)             (40,976)    Total stockholders’ equity                86,854                 89,444      Total liabilities and stockholders’ equity $             116,525  $             119,226      
The accompanying notes are an integral part of these statements.

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eResearchTechnology, Inc. and SubsidiariesConsolidated Statements of Operations(In thousands, except per share amounts)(unaudited)
  Three Months Ended September 30,   Nine Months Ended September 30,         2004  2005  2004  2005       Net revenues:             Licenses  $             2,675   $             1,009   $             7,798   $             4,418  Services  19,845   15,037   58,163   42,184  Site support  5,484   4,880   16,299   14,815  Total net revenues  28,004   20,926   82,260   61,417  Costs of revenues:             Cost of licenses  163   82   516   319  Cost of services  6,053   6,108   18,119   18,174  Cost of site support  3,050   3,455   7,995   9,786  Total costs of revenues  9,266   9,645   26,630   28,279  Gross margin  18,738   11,281   55,630   33,138  Operating expenses:             Selling and marketing  2,534   2,208   7,351   6,653  General and administrative  2,562   2,685   7,062   8,220  Research and development  1,031   1,081   3,046   2,975  Total operating expenses  6,127   5,974   17,459   17,848  Operating income  12,611   5,307   38,171   15,290  Other income, net  255   321   447   486  Income before income taxes  12,866   5,628   38,618   15,776  Income tax provision  5,506   1,601   15,858   5,711  Net income  $             7,360   $             4,027   $           22,760   $           10,065  Basic net income per share  $               0.14   $               0.08   $               0.44   $               0.20  Diluted net income per share  $               0.13   $               0.08   $               0.41   $               0.19  Shares used to calculate basic             net income per share  51,951   50,158   51,488   50,305  Shares used to calculate diluted             net income per share  55,473   52,979   55,483   53,145  
The accompanying notes are an integral part of these statements.

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eResearchTechnology, Inc. and SubsidiariesConsolidated Statements of Cash Flows(In thousands)(unaudited)
  Nine Months Ended September 30,       2004  2005     Operating activities:       Net income $     22,760  $     10,065  Adjustments to reconcile net income to net cash       provided by operating activities:       Depreciation and amortization         6,330          7,940  Cost of sale of equipment            295             312  Provision for uncollectible accounts            126               88  Stock option income tax benefits       11,919          1,587  Investment impairment charge  —            284  Changes in operating assets and liabilities:       Accounts receivable       (4,569)        2,934  Prepaid expenses and other       (1,988)      (2,149)Accounts payable          (525)           691  Accrued expenses          (350)           257  Income taxes         2,393             195  Deferred revenues      10,651             522  Net cash provided by operating activities      47,042        22,726  Investing activities:       Purchases of property and equipment     (12,033)    (10,842)Purchases of short-term investments     (21,058)    (29,077)Proceeds from sales of short-term investments      11,669        18,035  Net cash used in investing activities    (21,422)    (21,884)Financing activities:       Repayment of capital lease obligations          (608)         (196)Proceeds from exercise of stock options         3,138          1,094  Repurchase of common stock for treasury       (6,557)      (9,421)Net cash used in financing activities      (4,027)      (8,523)        Effect of exchange rate changes on cash             57           (287)Net increase (decrease) in cash and cash equivalents       21,650        (7,968)Cash and cash equivalents, beginning of period      38,364        45,806  Cash and cash equivalents, end of period  $     60,014  $     37,838  
The accompanying notes are an integral part of these statements.

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**eResearchTechnology, Inc. and Subsidiaries****Notes to Consolidated Financial Statements****(unaudited)**

**Note 1. Basis of Presentation**

The accompanying unaudited consolidated financial statements, which include the accounts of eResearchTechnology, Inc. (the “Company” or “we”) and its wholly-owned subsidiaries, have been prepared in accordance with generally accepted accounting principles for interim financial information and with the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, they do not include all the information and footnotes required by generally accepted accounting principles for complete financial statements. In the opinion of management, all adjustments (consisting of normal recurring adjustments) considered necessary for a fair presentation have been included. Operating results for thenine-month period ended September 30, 2005 are not necessarily indicative of the results that may be expected for the year ending December 31, 2005. Further information on potential factors that could affect our financial results can be found in our Report on Form 10-K for the year ended December 31, 2004 filed with the Securities and Exchange Commission and in this Form 10-Q. 

**Note 2. Summary of Significant Accounting Policies**

**Principles of Consolidation**

The accompanying consolidated financial statements include the accounts of the Company and its subsidiaries.  All significant intercompany accounts and transactions have been eliminated.

**Use of Estimates**

The preparation of financial statements in accordance with accounting principles generally accepted in the United States requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported revenues and expenses during the reporting period.  Actual results could differ from those estimates.

**Property and Equipment**

Pursuant to Statement of Position 98-1, “Accounting for the Costs of Computer Software Developed or Obtained for Internal Use,” we capitalize costs associated with internally developed and/or purchased software systems for new products and enhancements to existing products that have reached the application development stage and meet recoverability tests.  These costs are included in property and equipment.  Capitalized costs include external direct costs of materials and services utilized in developing or obtaining internal-use software, and payroll and payroll-related expenses for employees who are directly associated with and devote time to the internal-use softwareproject. 

Amortization of capitalized software development costs is charged to cost of revenues.  Amortization of capitalized software development costs was $484,000 and $304,000 for the three months ended September 30, 2004 and 2005, respectively, and $1,662,000 and $979,000 for the nine months ended September 30, 2004 and 2005, respectively. For the nine months ended September 30, 2004 and 2005, we capitalized $1,578,000 and $2,678,000, respectively, of software development costs related to labor and consulting, and $1,139,000 and $0, respectively, of software development costs related to direct costs of materials.  As of September 30, 2005, $5,736,000 of capitalized costs have not yet been placed in service andare therefore not being amortized.

**Long-lived Assets**

In accordance with the provisions of Statement of Financial Accounting Standards (SFAS) No. 144, “Accounting for the Impairment or Disposal of Long-Lived Assets,” when events or circumstances so indicate, we assess the potential impairment of our long-lived assets based on anticipated undiscounted cash flows from the assets. Such events and circumstances include a sale of all or a significant part of the operations associated with the long-lived asset, or a significant decline in the operating performance of the asset. If an impairment is indicated, the amount of the impairment charge would be calculated by comparing the anticipated discounted future cash flows to the carrying value of the long-livedasset. At   September 30, 2005, no impairment was indicated.

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**Software Development Costs**

Research and development expenditures are charged to operations as incurred. SFAS No. 86, “Accounting for the Costs of Computer Software to be Sold, Leased, or Otherwise Marketed,” requires the capitalization of certain software development costs subsequent to the establishment of technological feasibility. Since software development costs have not been significant after the establishment of technological feasibility, all such costs have been charged to expense as incurred. 

**Stock-Based Compensation**

SFAS No. 123, “Accounting for Stock-Based Compensation,” as amended by SFAS No. 148, “Accounting for Stock-Based Compensation – Transition and Disclosure,” permits companies to (i) recognize as expense the fair value of stock-based awards, or (ii) continue to apply the provisions of Accounting Principles Board (APB) Opinion No. 25, “Accounting for Stock Issued to Employees” and related interpretations, and provide pro forma net income and earnings per share disclosures for employee stock option grants as if the fair value based method defined in SFAS No. 123 had been applied. We continue to apply the provisions of APB Opinion No. 25 and provide the pro forma disclosures inaccordance with the provisions of SFAS Nos. 123 and 148. Under APB Opinion No. 25, we have not recorded any stock-based employee compensation cost associated with our stock option plans, as all options granted under the plans had an exercise price equal to the market value of the underlying common stock on the date of grant. 

The following table illustrates the effect on net income and earnings per share if we had applied the fair value recognition provisions of SFAS No. 123 to our stock option plans (in thousands, except per share amounts):
  Three Months Ended September 30, Nine Months Ended September 30,       2004 2005 2004 2005       Net income, as reported $             7,360  $           4,027  $          22,760  $          10,065  Deduct: Net stock-based employee compensation expense             determined under fair value based method, net of related             tax effects                (704)             (624)          (2,619)          (2,152)Pro forma net income $             6,656  $           3,403  $          20,141  $            7,913  Earnings per share:             Basic – as reported $               0.14  $             0.08  $              0.44  $              0.20  Basic – pro forma $               0.13  $             0.07  $              0.39  $              0.16                Diluted – as reported $               0.13  $             0.08  $              0.41  $              0.19  Diluted – pro forma $               0.12  $             0.06  $              0.36  $              0.15  
Pro forma net income reflects only options granted through September 30, 2005 and, therefore, may not be representative of the effect for future periods.

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**Note 3. Net Income per Common Share**

Basic net income per share is computed by dividing net income by the weighted average number of shares of common stock outstanding during the period. Diluted net income per share is computed by dividing net income by the weighted average number of shares of common stock outstanding during the period, adjusted for the dilutive effect of common stock equivalents, which consist of stock options.  The dilutive effect of stock options is calculated using the treasury stock method.

The tables below set forth the reconciliation of the numerators and denominators of the basic and diluted net income per share computations (in thousands, except per share amounts):
Three Months Ended September 30,              Per   Net    Share 2004 Income Shares Amount Basic net income  $          7,360           51,951   $     0.14  Effect of dilutive shares  —            3,522        (0.01)Diluted net income  $          7,360           55,473   $     0.13  2005                    Basic net income  $          4,027           50,158   $     0.08  Effect of dilutive shares  —            2,821   — Diluted net income  $          4,027           52,979   $     0.08  Nine Months Ended September 30,                 Per   Net    Share 2004 Income Shares Amount            Basic net income  $        22,760           51,488   $     0.44  Effect of dilutive shares  —            3,995        (0.03)Diluted net income  $        22,760           55,483   $     0.41  2005                    Basic net income  $        10,065           50,305   $     0.20  Effect of dilutive shares  —            2,840        (0.01)Diluted net income  $        10,065           53,145   $     0.19  
In computing diluted net income per share, 1,159,000 options to purchase shares of common stock were excluded from the computations for the three and nine months ended September 30, 2005.  These options were excluded from the computations because the exercise prices of such options were greater than the average market price of our common stock during the respective periods.

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**Note 4. Comprehensive Income**

SFAS No. 130, “Reporting Comprehensive Income,” requires companies to classify items of other comprehensive income by their nature in the financial statements and display the accumulated balance of other comprehensive income separately from retained earnings and additional paid-in-capital in the stockholders’ equity section of the balance sheet. Our comprehensive income includes net income and unrealized gains and losses from foreign currency translation as follows (in thousands):
  Three Months Ended September 30, Nine Months Ended September 30,       2004 2005 2004 2005       Net income $        7,360  $        4,027  $     22,760  $     10,065                Other comprehensive income (loss):                  Currency translation adjustment              18            (187)            89          (733)      Comprehensive income $        7,378  $        3,840  $     22,849  $       9,332        
**Note 5. Income Taxes**

In the third quarter of 2005 and effective for 2004, we changed our transfer pricing methodology for the majority of our revenue categories to the profit split methodology as a result of a shift to a more global approach to the management of operations.  Beginning in 2004, we shifted to a more flexible global operation where work on a study is shared among offices.   While we had a transfer pricing methodology in place in 2004, we undertook a study in 2005 to determine the best available transfer pricing methodology.  The profit split methodology equalizes gross margins for each legal entity based upon their respective direct costs.  While we believe that the profit split methodology is the best available methodologycurrently, we will continue to assess the available options.  In addition, we determined that all license revenue should be recognized by our operations based in the United States. As a result of the change in the transfer pricing methodology, we recorded an income tax benefit in the third quarter of 2005 of $560,000 related to the recovery of prior year taxes and an adjustment to the year-to-date effective tax rate.  

**Note 6. Recent Pronouncements**

In December 2004, the Financial Accounting Standards Board (FASB) issued SFAS No. 123R, “Share-Based Payment.”  SFAS No. 123R is a revision of SFAS No. 123.  SFAS No. 123R establishes standards for the accounting for transactions in which an entity exchanges its equity instruments for goods or services.  SFAS No. 123R requires companies to recognize in the statement of operations the grant-date fair value of stock options and other equity-based compensation issued to employees, but expresses no preference for a type of valuation model.  In April 2005, the Securities and Exchange Commission (SEC) issued Staff Accounting Bulletin No. 107 which provided additional guidance in implementing SFAS No. 123Rwithout modifying the conclusions or requirements of SFAS No. 123R.  In April 2005, the SEC also deferred the effective date of SFAS No. 123R for many registrants, including our company.  The deferral now requires the adoption to be effective for our company no later than the first annual period beginning after June 15, 2005.  We currently use the intrinsic value method to measure compensation expense for stock-based awards to our employees.  Accordingly, we do not recognize any compensation expense related to stock option grants that we issue under our stock option plans.  Under the new rules, we will be required to adopt a fair value based method for measuring the expense and this may materially impact our future reported results of operations.  We are evaluating the impact on ourresults from adopting SFAS No. 123R, and we expect it to be comparable to the pro forma effects of applying the original SFAS No. 123 (see “Stock-Based Compensation” in Note 2 for further details).  

In December 2004, the FASB issued SFAS No. 153, “Exchanges of Nonmonetary Assets,” which eliminates an exception in APB Opinion No. 29, “Accounting for Nonmonetary Transactions,” for nonmonetary exchanges of similar productive assets and replaces it with a general exception for exchanges of nonmonetary assets that do not have commercial substance.  SFAS No. 153 became effective for us for nonmonetary asset exchanges occurring in fiscal periods beginning after June 15, 2005.  The adoption of SFAS No. 153 did not have any impact on our consolidated financial statements.

In May 2005, the FASB issued SFAS No. 154, “Accounting Changes and Error Corrections.”  SFAS No. 154 requires retroactive application of a voluntary change in accounting principle to prior period financial statements unless it is impracticable. SFAS No. 154 also requires that a change in method of depreciation, amortization, or depletion for long-lived, 

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non-financial assets be accounted for as a change in accounting estimate that is affected by a change in accounting principle.  SFAS No. 154 replaces APB Opinion 20, “Accounting Changes,” and SFAS No. 3, “Reporting Accounting Changes in Interim Financial Statements.”  SFAS No. 154 will be effective for accounting changes and corrections of errors made in fiscal years beginning after December 15, 2005. Management currently believes that adoption of the provisions of SFAS No. 154 will not have a material impact on the Company’s consolidated financial statements.

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**Note 7. Operating Segments / Geographic Information**

Since 2003, we have considered our operations to consist of one segment as this represents management’s view of our operations.  We operate on a worldwide basis with two locations in the United States and one location in the United Kingdom, which are categorized below as North America and Europe, respectively.  The majority of our revenues are allocated based upon the profit split methodology as discussed in Note 5.  The 2004 and 2005 information presented in the tables below has been adjusted to reflect the impact of the changes in transfer pricing as if the changes were in effect as of January 1, 2004.

Geographic information is as follows (in thousands of dollars):
  **Three Months Ended September 30, 2004**      **North**         **America** **Europe** **Total**        License revenues $               2,675  $— $               2,675  Service revenues               16,185                  3,660                19,845  Site support revenues                4,394                  1,090                  5,484         Net revenues from external customers $             23,254  $               4,750  $             28,004         Operating income $             10,948  $               1,663  $             12,611  Long-lived assets $             14,661  $               4,956  $             19,617  Identifiable assets $           121,257  $             12,549  $           133,806    **Three Months Ended September 30, 2005**      **North**         **America** **Europe** **Total**        License revenues $               1,009  $— $               1,009  Service revenues               12,247                  2,790                15,037  Site support revenues                3,670                  1,210                  4,880         Net revenues from external customers $             16,926  $               4,000  $             20,926         Operating income $               4,785  $                  522  $               5,307  Long-lived assets $             17,844  $               9,237  $             27,081  Identifiable assets $           105,161  $             14,065  $           119,226    **Nine Months Ended September 30, 2004**      **North**         **America** **Europe** **Total**        License revenues $               7,798  $— $               7,798  Service revenues               46,987                11,176                58,163  Site support revenues              13,096                  3,203                16,299         Net revenues from external customers $             67,881  $             14,379  $             82,260         Operating income $             32,902  $               5,269  $             38,171  Long-lived assets $             14,661  $               4,956  $             19,617  Identifiable assets $           121,257  $             12,549  $           133,806    **Nine Months Ended September 30, 2005**      **North**         **America** **Europe** **Total**        License revenues $               4,418  $— $               4,418  Service revenues               33,543                  8,641                42,184  Site support revenues              10,951                  3,864                14,815         Net revenues from external customers $             48,912  $             12,505  $             61,417         Operating income $             13,645  $               1,645  $             15,290  Long-lived assets $             17,844  $               9,237  $             27,081  Identifiable assets $           105,161  $             14,065  $           119,226  
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**Item 2. Management’s Discussion      and Analysis of Financial Condition and Results of Operations**

**Cautionary Statement for Forward-Looking Information**

The following discussion and analysis should be read in conjunction with our consolidated financial statements and the related notes to the consolidated financial statements appearing elsewhere in this Form 10-Q. The following discussion includes a number of forward-looking statements made pursuant to the safe-harbor provisions of the Private Securities Litigation Reform Act of 1995 that reflect our current views with respect to future events and financial performance. We use words such as anticipate, believe, expect, intend, and similar expressions to identify forward-looking statements. You should not place undue reliance on these forward-looking statements, which apply only as of the date of this report. Theseforward-looking statements are subject to risks and uncertainties such as the Company’s ability to obtain new contracts and accurately estimate net revenues due to uncertain regulatory guidance, variability in size, scope and duration of projects, and internal issues at the sponsoring client, competitive factors, technological development, and market demand. These and other risk factors have been further discussed in our Form 10-K for the year ended December 31, 2004. Such risks and uncertainties could cause actual results to differ materially from historical results or future predictions. Further information on potential factors that could affect our financial results can be found throughout this Form 10-Q and our other reports filed with the Securities and Exchange Commission.

**Overview**

We were founded in 1977 to provide Cardiac Safety services to evaluate the safety of new drugs.  We provide technology and services that enable the pharmaceutical, biotechnology and medical device industries to collect, interpret and distribute cardiac safety and clinical data more efficiently.  We are a market leader in providing centralized electrocardiographic services (Cardiac Safety services or EXPeRT® ECG services) and a leading provider of technology and services that streamline the clinical trials process by enabling our clients to evolve from traditional, paper-based methods to electronic processing using our Clinical Data Management products and services. 

Our solutions improve the accuracy, timeliness and efficiency of trial set-up, data collection from sites worldwide, data interpretation and new drug, biologic and device application submission.  We offer Cardiac Safety services, which are utilized by clinical trial sponsors and clinical research organizations (CROs) during the conduct of clinical trials, including comprehensive Thorough QTc studies.  Services may be provided through the Digital ECG Franchise program, which offers a unique approach designed to address the capacity demands for eRT’s ECG services through partnerships with sponsors that desire dedicated resources within eRT to address specific levels of cardiac safety monitoring transactions.Additionally, we offer the licensing and, at the client’s option, hosting of our proprietary Clinical Data Management software products and the provision of maintenance and consulting services in support of our proprietary Clinical Data Management software products.  We offer the following products and services on a global basis: 
 *EXPeRT®*.  EXPeRT® Cardiac Safety services provide intelligent, workflow-enabled cardiac safety data collection, interpretation and distribution of electrocardiographic (ECG) data and images, as well as analysis and cardiologist interpretation of ECGs performed on research subjects in connection with our clients’ clinical trials.  In addition, we establish rules for standardized, semi-automated and automated workflow management, allowing audit trail accounting and generating safety and operational metrics reports for sponsors and investigators. Also included in EXPeRT® Cardiac Safety services is FDA XML delivery which provides for the delivery of ECGs, encapsulated in the now approved FDA XML schema standard, to Cardiac Safetycustomers.   *eRCTM.*eResearch CommunityTM (eRC) is a central command and control portal that provides real-time information related to monitoring clinical trial activities, data quality and safety.   *eDETM.*  eData EntryTM (eDE) technology provides a comprehensive electronic data capture (EDC) system comprised of technology and consulting services formulated to deliver rapid time to benefit for electronic trial initiatives.    *eResNetTM.*  The eResearch NetworkTM (eResNet) technology provides an integrated end-to-end clinical research solution that includes trials, data and safety management modules.   *Project Assurance/Implementation Assurance*.  We provide a full spectrum of consulting services for all of our products that augment the study management and implementation efforts of clients in support of their clinical research requirements.
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Our license revenues consist of license fees for perpetual licenses and monthly and annual license sales. Our services revenues consist of Cardiac Safety services, technology consulting and training services and software maintenance services. Our site support revenue consists of cardiac safety equipment rentals and sales along with related supplies and freight.

We recognize software revenues in accordance with Statement of Position 97-2, “Software Revenue Recognition,” as amended by Statement of Position 98-9. Accordingly, we recognize up-front license fee revenues under the residual method when a formal agreement exists, delivery of the software and related documentation has occurred, collectability is probable and the license fee is fixed or determinable. We recognize monthly and annual license fee revenues over the term of the arrangement. Hosting service fees are recognized evenly over the term of service. Cardiac Safety services revenues consist of fee for service revenues and are recognized as the services are performed.  Site support revenues arerecognized at the time of sale or over the rental period. We recognize revenues from software maintenance contracts on a straight-line basis over the term of the maintenance contract, which is typically twelve months. We provide consulting and training services on a time and materials basis and recognize revenues as we perform the services. 

For arrangements with multiple deliverables where the fair value of each element is known, the revenue is allocated to each component based on the relative fair values of each element.  For arrangements with multiple deliverables where the fair value of the delivered element, primarily the license fee, is not known, revenue is allocated to each component of the arrangement using the residual method provided that the fair value of all undelivered elements is known.  Fair values for undelivered elements are based primarily upon stated renewal rates for future products or services.

Cost of licenses consists primarily of applications service provider (ASP) fees for those clients that choose hosting, the cost of producing compact disks and related documentation and royalties paid to third parties in connection with their contributions to our product development. Cost of services includes the cost of Cardiac Safety services and the cost of technology consulting, training and maintenance services. Cost of Cardiac Safety services consists primarily of direct costs related to our centralized Cardiac Safety services and includes wages, depreciation and other direct operating costs.  Cost of technology consulting, training and maintenance services consists primarily of wages, fees paid to outsideconsultants and other direct operating costs related to our consulting and client support functions. Cost of site support consists primarily of wages, cardiac safety equipment rent and depreciation, related supplies, cost of equipment sold, shipping expenses and other direct operating costs.  Selling and marketing expenses consist primarily of wages and commissions paid to sales personnel, travel expenses and advertising and promotional expenditures. General and administrative expenses consist primarily of wages and direct costs for our finance, administrative, corporate information technology and executive management functions, in addition to professional service fees and corporate insurance. Research and development expenses consist primarily of wages paid to our product developmentstaff, costs paid to outside consultants and direct costs associated with the development of our technology products.

We conduct our operations through offices in the United States (US) and the United Kingdom (UK). Our international net revenues represented approximately 17% and 20% of total net revenues for the nine months ended September 30, 2004 and 2005, respectively.  The majority of our revenues are allocated based upon the profit split transfer pricing methodology.  The international net revenues as a percentage of total net revenues reflect the application of the change in transfer pricing methodology, as discussed in Note 5 in Notes to Consolidated Financial Statements elsewhere in this Form 10-Q, as if the changes were in effect as of January 1, 2004.  See Note 7 in Notes to Consolidated Financial Statements elsewhere inthis Form 10-Q for a detailed discussion of revenue recognition among the geographic segments.

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**Results of Operations**

**Executive Overview**

On October 3, 2005, we announced approximately $32 million in third quarter signings setting a new record for quarterly signings, capped by two late phase program awards from two Top 15 global pharmaceuticals awarded at quarter end.   Despite the record signings, we have yet to see significant increases in signings of Thorough QTc studies in response to the May 12, 2005 ratification by the International Committee on Harmonization (ICH) of the implementation (step 4) of the cardiac safety monitoring guidance provided in E14: The Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs.   Regulatory bodies, such as the United States Food and Drug Administration(FDA) and the ICH, provide guidance on the clinical trial process.  This guidance can have a significant influence on the decisions made by our clients and potential clients regarding the use of our services.  The ICH E14 guidance confirms previous guidance reinforcing the need for routine cardiac safety testing as well as Thorough QTc testing for all compounds entering the blood stream commencing early in clinical development to provide maximum guidance for later trials, as well as testing for all compounds in Phase III prior to submission for approval.

Although we believe that the ICH E14 guidance should eventually alleviate the regulatory uncertainty that has existed, we believe the uncertainty has temporarily impacted our industry, and that our results of operations have been adversely affected and could continue to be adversely affected until the guidance is fully adopted by our clients.    

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The following table presents certain financial data as a percentage of total net revenues:
  Three Months Ended September 30,  Nine Months Ended September 30,        2004 2005 2004 2005 Net revenues:         Licenses 9.6% 4.8% 9.5% 7.2% Services 70.8% 71.9% 70.7% 68.7% Site support 19.6% 23.3% 19.8% 24.1% Total net revenues 100.0% 100.0% 100.0% 100.0% Costs of revenues:         Cost of licenses 0.6% 0.4% 0.6% 0.5% Cost of services 21.6% 29.2% 22.1% 29.6% Cost of site support 10.9% 16.5% 9.7% 15.9% Total costs of revenues 33.1% 46.1% 32.4% 46.0% Gross margin 66.9% 53.9% 67.6% 54.0% Operating expenses:         Selling and marketing 9.1% 10.5% 8.9% 10.8% General and administrative 9.1% 12.8% 8.6% 13.4% Research and development 3.7% 5.2% 3.7% 4.9% Total operating expenses 21.9% 28.5% 21.2% 29.1% Operating income 45.0% 25.4% 46.4% 24.9% Other income, net 0.9% 1.5% 0.5% 0.8% Income before income taxes 45.9% 26.9% 46.9% 25.7% Income tax provision 19.6% 7.7% 19.2% 9.3% Net income 26.3% 19.2% 27.7% 16.4% 
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**Three Months Ended September 30, 2005 Compared to Three Months Ended September 30, 2004.**

The following table presents statements of operations with product line detail (in thousands):
  **Three Months Ended September 30,**            **2004** **2005** **Increase (Decrease)**      Licenses:             Net revenues $               2,675  $               1,009  $         (1,666) (62.3%)Costs of revenues                   163                      82                (81) (49.7%)          Gross margin $               2,512  $                  927  $         (1,585) (63.1%)        Services:             Cardiac Safety             Net revenues $             17,925  $             13,149  $         (4,776) (26.6%)Costs of revenues                5,170                 5,369               199   3.8%           Gross margin $             12,755  $               7,780  $         (4,975) (39.0%)        Technology consulting and training             Net revenues $                  811  $                  649  $            (162) (20.0%)Costs of revenues                   599                    490              (109) (18.2%)          Gross margin $                  212  $                  159  $              (53) (25.0%)        Software maintenance             Net revenues $               1,109  $               1,239  $             130   11.7% Costs of revenues                   284                    249                (35) (12.3%)          Gross margin $                  825  $                  990  $             165   20.0%         Total services             Net revenues $             19,845  $             15,037  $         (4,808) (24.2%)Costs of revenues                6,053                 6,108                 55   0.9%           Gross margin $             13,792  $               8,929  $         (4,863) (35.3%)        Site support:             Net revenues $               5,484  $               4,880  $            (604) (11.0%)Costs of revenues                3,050                 3,455               405   13.3%           Gross margin $               2,434  $               1,425  $         (1,009) (41.5%)        Total:             Net revenues $             28,004  $             20,926  $         (7,078) (25.3%)Costs of revenues                9,266                 9,645               379   4.1%           Gross margin              18,738               11,281           (7,457) (39.8%)          Operating expenses:             Selling and marketing                 2,534                  2,208               (326) (12.9%)General and administrative                 2,562                  2,685                123   4.8% Research and development                 1,031                  1,081                  50   4.8%           Total operating expenses                6,127                 5,974              (153) (2.5%)          Operating income               12,611                  5,307            (7,304) (57.9%)Other income, net                   255                    321                 66   25.9%           Income before income taxes               12,866                  5,628            (7,238) (56.3%)Income tax provision                 5,506                  1,601            (3,905) (70.9%)          Net income $               7,360  $               4,027  $         (3,333) (45.3%)        
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The following table presents costs of revenues as a percentage of related net revenues and operating expenses as a percentage of total net revenues:
 **Three Months Ended September 30,**     **Increase**  **2004** **2005** **(Decrease)**     Cost of licenses6.1% 8.1% 2.0% Cost of services:      Cardiac Safety28.8% 40.8% 12.0% Technology consulting and training73.9% 75.5% 1.6% Software maintenance25.6% 20.1% (5.5%)Total cost of services30.5% 40.6% 10.1% Cost of site support55.6% 70.8% 15.2% Total costs of revenues33.1% 46.1% 13.0% Operating expenses:      Selling and marketing9.1% 10.5% 1.4% General and administrative9.1% 12.8% 3.7% Research and development3.7% 5.2% 1.5% 
License revenues decreased primarily due to a decline in the number of licenses sold and a decrease in the average license revenue for each license sold.  This was largely the result of the mix of licenses sold and the number of users for each license.  

The decrease in Cardiac Safety service revenues was primarily due to a decrease in volume, including a decrease in transactions performed and a decrease in average revenue per transaction.  The decrease in sales volume in the third quarter of 2005 was partially attributable to a slowdown in contract signings in the prior few quarters, delays in certain studies and a decrease in comprehensive Thorough QTc studies.  Thorough QTc studies are typically of large volume and of short duration, with ECGs performed over a two- to six-month period. As a result, revenues resulting from Thorough QTc studies are more difficult to predict.  The decrease in average revenue per transaction was largelydue to the impact of increased activity in franchise accounts and semi-automated processing, which generally include lower fees per transaction than other studies, as well as competitive pricing adjustments.  If drug sponsors continue to shift towards semi-automated processing using software algorithm placed measurements in place of our manual high-resolution caliper placement system, average revenue per transaction could continue to decrease.

Technology consulting and training revenues decreased primarily due to a reduction in configuration revenue related to reporting for Cardiac Safety customers as a result of the decrease in Cardiac Safety activity.

Software maintenance revenues increased due to software licenses sold after the third quarter of 2004, which increased the number of total active licenses and their related maintenance fees.

Site support revenue decreased primarily due to a large sale of cardiac safety equipment in 2004 with only small sale transactions in 2005 as well as a decrease in revenue from the rental of cardiac safety equipment, which our clients use to perform cardiac safety procedures.  This was driven largely by a reduction in the average revenue per equipment unit due to competitive pricing in the cardiac safety services market.

The decrease in cost of licenses was primarily due to a reduction in third party ASP hosting fees.  The increase in cost of licenses as a percentage of license revenues was due to the decrease in perpetual license revenues which have very little incremental cost of sales, such that revenue reductions lead to minimal cost savings.

The increase in the cost of Cardiac Safety services, both in absolute terms and as a percentage of Cardiac Safety service revenues, was primarily due to labor, depreciation and increased facilities and other costs associated with expanding capabilities to meet the past and expected future growth in Cardiac Safety service revenues.  These increases were partially offset by a reduction in amortization expense related to internal use software costs.  See “Liquidity and Capital Resources” for additional information related to internal use software.  Additionally, the increase in the cost of Cardiac Safety services as a percentage of Cardiac Safety service revenues was due to the fact that some of the costs donot necessarily increase or decrease in direct relation with changes in revenue.

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The decrease in the cost of technology consulting and training services was primarily due to a reduction in labor costs.  The increase in the cost of technology consulting and training services as a percentage of technology consulting and training service revenues was due to the fact that some of the costs do not necessarily increase or decrease in direct relation with changes in revenue.

The increase in the cost of site support, both in absolute terms and as a percentage of site support revenues, was due primarily to an increase in depreciation and rental costs associated with cardiac safety rental equipment and other costs associated with expanding capabilities to meet the past and expected growth in site support activities, including the addition of new dedicated site support facilities in both the US and UK during the second half of 2004. Partially offsetting the increase was a reduction in the cost of sales of equipment due to significantly lower equipment sales in 2005.  The increase in the cost of site support as a percentage of site support revenues was also due to the fact that some of thecosts do not necessarily increase or decrease in direct relation with changes in revenue.

The decrease in selling and marketing expenses was primarily due to lower commissions that resulted from a decrease in commissionable revenue and the conversion of certain business development directors from incentive compensation based upon commissions on individual studies to incentive compensation based upon bonus.  In the third quarter of 2005, performance against bonus targets improved which resulted in an increase in bonus expense and partially offset the commission expense reduction.  The increase in selling and marketing expenses as a percentage of total net revenues was due to maintaining other selling and marketing expenditures, including labor, despite the decrease in total net revenues.

The increase in general and administrative expenses, both in absolute terms and as a percentage of total net revenues, was due primarily to increased audit and internal control attestation fees of our independent registered public accountants and other professional fees and higher labor costs related to new hires. These increases were partially offset by a reduction in the cost of consultants related to internal control work required by the Sarbanes-Oxley Act.  The increase in general and administrative expenses as a percentage of total net revenues was also due to the decrease in net revenues and the fact that general and administrative expenses do not necessarily increase or decrease with changes in revenues.

The increase in research and development expenses, both in absolute terms and as a percentage of total net revenues,  was due primarily to increased labor and recruitment costs related to new hires and consulting costs.  Research and development expenses as a percentage of net revenues also increased due to the decrease in net revenues and the fact that many of the research and development expenses do not necessarily increase or decrease with changes in revenues.  

Other income, net, consisted primarily of interest income realized from our cash, cash equivalents and short-term investments, net of interest expense related to capital lease obligations and foreign exchange losses.  Other income, net increased primarily due to a shift to higher yielding money market investments and a decrease in interest expense related to capital leases in the third quarter of 2005.  The increase was partially offset by foreign exchange losses in 2005.

Our effective tax rate was 42.8% and 28.4% for the three months ended September 30, 2004 and 2005, respectively.  The tax rate for the three months ended September 30, 2005 included a tax benefit of approximately $560,000 related to the recovery of prior year taxes and an adjustment to the year-to-date effective tax rate, primarily due to a change in our transfer pricing methodology. We expect our effective tax rate for the fourth quarter of 2005 to be 38.4%. 

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**Nine Months Ended September 30, 2005 Compared to Nine Months Ended September 30, 2004.**

The following table presents statements of operations with product line detail (in thousands):
  **Nine Months Ended September 30,**            **2004** **2005** **Increase (Decrease)**      Licenses:             Net revenues $               7,798  $                 4,418  $           (3,380) (43.3%)Costs of revenues                   516                    319              (197) (38.2%)          Gross margin $               7,282  $               4,099  $         (3,183) (43.7%)        Services:             Cardiac Safety             Net revenues $             52,298  $             36,881  $       (15,417) (29.5%)Costs of revenues              15,152               15,970               818   5.4%           Gross margin $             37,146  $             20,911  $       (16,235) (43.7%)        Technology consulting and training             Net revenues $               2,564  $               1,696  $            (868) (33.9%)Costs of revenues                2,105                 1,408              (697) (33.1%)          Gross margin $                  459  $                  288  $            (171) (37.3%)        Software maintenance             Net revenues $               3,301  $               3,607  $             306   9.3% Costs of revenues                   862                    796                (66) (7.7%)          Gross margin $               2,439  $               2,811  $             372   15.3%         Total services             Net revenues $             58,163  $             42,184  $       (15,979) (27.5%)Costs of revenues              18,119               18,174                 55   0.3%           Gross margin $             40,044  $             24,010  $       (16,034) (40.0%)        Site support:             Net revenues $             16,299  $             14,815  $         (1,484) (9.1%)Costs of revenues                7,995                 9,786            1,791   22.4%           Gross margin $               8,304  $               5,029  $         (3,275) (39.4%)        Total             Net revenues $             82,260  $             61,417  $       (20,843) (25.3%)Costs of revenues              26,630               28,279            1,649   6.2%           Gross margin              55,630               33,138         (22,492) (40.4%)          Operating expenses:             Selling and marketing                 7,351                  6,653               (698) (9.5%)General and administrative                 7,062                  8,220             1,158   16.4% Research and development                 3,046                  2,975                 (71) (2.3%)          Total operating expenses              17,459               17,848               389   2.2%           Operating income               38,171                15,290          (22,881) (59.9%)Other income, net                   447                    486                 39   8.7%           Income before income taxes               38,618                15,776          (22,842) (59.1%)Income tax provision               15,858                  5,711          (10,147) (64.0%)          Net income $             22,760  $              10,065  $        (12,695) (55.8%)        
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The following table presents costs of revenues as a percentage of related net revenues and operating expenses as a percentage of total net revenues:
  **Nine Months Ended September 30,**      **Increase**   **2004** **2005** **(Decrease)**      Cost of licenses 6.6% 7.2% 0.6% Cost of services:       Cardiac Safety 29.0% 43.3% 14.3% Technology consulting and training 82.1% 83.0% 0.9% Software maintenance 26.1% 22.1% (4.0%)Total cost of services 31.2% 43.1% 11.9% Cost of site support 49.1% 66.1% 17.0% Total costs of revenues 32.4% 46.0% 13.6% Operating expenses:       Selling and marketing 8.9% 10.8% 1.9% General and administrative 8.6% 13.4% 4.8% Research and development 3.7% 4.9% 1.2% 
License revenues decreased primarily due to a decline in the number of licenses sold and a decrease in the average license revenue for each license sold.  This was largely the result of the mix of licenses sold and the number of users for each license.  

The decrease in Cardiac Safety service revenues was primarily due to a decrease in volume, including a decrease in transactions performed and a decrease in average revenue per transaction.  The decrease in sales volume in the third quarter of 2005 was partially attributable to a slowdown in contract signings in the prior few quarters, delays in certain studies as well as a decrease in comprehensive Thorough QTc studies.  Thorough QTc studies are typically of large volume and of short duration, with ECGs performed over a two- to six-month period. As a result, revenues resulting from Thorough QTc studies are more difficult to predict.  The decrease in average revenue per transaction waslargely due to the impact of increased activity in franchise accounts and semi-automated processing, which generally include lower fees per transaction than other studies, as well as competitive pricing adjustments.  

Technology consulting and training revenues decreased primarily due to a reduction in consulting on Clinical Data Management software products as there was a greater number of consulting engagements in the nine months ended September 30, 2004 than in the same period in 2005.

Software maintenance revenues increased due to software licenses sold after the third quarter of 2004, which increased the number of total active licenses and their related maintenance fees.

Site support revenue decreased primarily due to a large sale of cardiac safety equipment in 2004 with only small sale transactions in 2005 as well as a decrease in revenue from the rental of cardiac safety equipment, which our clients use to perform cardiac safety procedures.  This was driven largely by a reduction in the average revenue per equipment unit due to competitive pricing in the cardiac safety services market.

The decrease in cost of licenses was primarily due to a royalty paid in 2004 to a third-party software developer related to the sale of one of the perpetual licenses.  The increase in cost of licenses as a percentage of license revenues was due to the decrease in perpetual license revenues which have very little incremental cost of sales, such that revenue reductions lead to minimal cost savings.

The increase in the cost of Cardiac Safety services, both in absolute terms and as a percentage of Cardiac Safety revenues, was primarily due to an increase in labor, depreciation and increased facilities and other costs associated with expanding capabilities to meet the past and expected future growth in Cardiac Safety service revenues. Partially offsetting these increases was a reduction in incentive bonuses due to higher targets set for the first half of 2005 that were not achieved, a reduction in amortization expense related to internal use software costs and a reduction in recruitment expenses.  See “Liquidity and Capital Resources” for additional information related to internal use software.Additionally, the increase in the 

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cost of Cardiac Safety services as a percentage of Cardiac Safety service revenues was due to the fact that some of the costs do not necessarily increase or decrease in direct relation with changes in revenue.

The decrease in the cost of technology consulting and training services was primarily due to a reduction in incentive bonuses due to higher targets set for the first half of 2005 that were unmet, a reduction in third-party consulting costs that was partially attributable to the decrease in related revenue, higher employee benefits costs in 2004 in connection with stock option exercises and a decrease in other labor costs.  The increase in the cost of technology consulting and training services as a percentage of technology consulting and training service revenues was due to the fact that some of the costs do not necessarily increase or decrease in direct relation with changes in revenue.

The increase in the cost of site support, both in absolute terms and as a percentage of site support revenues, was due primarily to an increase in depreciation and rental costs associated with cardiac safety rental equipment and other costs associated with expanding capabilities to meet the past and expected growth in site support activities, including the addition of new dedicated site support facilities in both the US and UK during the second half of 2004.  The increase in the cost of site support as a percentage of site support revenues was also due to the fact that some of the costs do not necessarily increase or decrease in direct relation with changes in revenue.

The decrease in selling and marketing expenses was primarily due to lower commissions that resulted from a decrease in commissionable revenue and the conversion of certain business development directors from incentive compensation based upon commission to incentive compensation based upon bonus.  In the third quarter of 2005, performance against bonus targets improved which resulted in an increase in bonus expense, which partially offset the commission expense reduction.  The increase in selling and marketing expenses as a percentage of total net revenues was due to maintaining other selling and marketing expenditures, including labor, despite the decrease in total net revenues.

The increase in general and administrative expenses, both in absolute terms and as a percentage of total net revenues, was due primarily to increased audit and internal control attestation fees of our independent registered public accountants and other professional fees, higher labor costs due to new hires and increases in depreciation, equipment, insurance and telephone expenses. These increases were partially offset by a reduction in incentive bonuses due to higher targets in the first half of 2005 that were not achieved.  The increase in general and administrative expenses as a percentage of total net revenues was also due to the decrease in net revenues and the fact that general and administrative expenses do notnecessarily increase or decrease with changes in revenues. 

The decrease in research and development expenses was due primarily to a reduction in consulting costs, a reduction in incentive bonuses due to higher targets in the first half of 2005 that were not achieved and the capitalization of expenditures related to internal use software development. Partially offsetting these decreases were increased labor and recruitment costs.  Research and development expenses as a percentage of net revenues increased due to the decrease in net revenues and the fact that many of the research and development expenses do not necessarily increase or decrease with changes in revenues.  

Other income, net, consisted primarily of interest income realized from our cash, cash equivalents and short-term investments, net of interest expense related to capital lease obligations, foreign exchange losses and an impairment charge related to a cost basis investment. Other income, net increased primarily due to a shift to higher yielding money market investments and a decrease in interest expense related to capital leases in the first nine months of 2005.   These increases were partially offset by foreign exchange losses in 2005 as well as an impairment charge in the first quarter of 2005 related to a cost basis investment.

Our effective tax rate was 41.1% and 36.2% for the nine months ended September 30, 2004 and 2005, respectively. The tax rate for the nine months ended September 30, 2005 included a tax benefit of approximately $560,000 related to the recovery of prior year taxes and an adjustment to the year-to-date effective tax rate, primarily due to a change in our transfer pricing methodology. We expect our effective tax rate for the fourth quarter of 2005 to be 38.4%. 

**Liquidity and Capital Resources**

At September 30, 2005, we had $37.8 million of cash and cash equivalents and $34.0 million invested in short-term investments.  We generally place our investments in money market funds, municipal securities, bonds of government sponsored agencies, certificates of deposit with fixed rates with maturities of less than one year, and A1P1 rated commercial bonds and paper.

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For the nine months ended September 30, 2005, our operations provided cash of $22.7 million compared to $47.0 million during the nine months ended September 30, 2004. The change was primarily the result of lower operating income and less income tax benefits related to stock options recognized during the nine months ended September 30, 2005 compared to the nine months ended September 30, 2004.  The decrease in operating cash flow was also attributable to a much smaller increase in deferred revenues in the nine months ended September 30, 2005 compared to the nine months ended September 30, 2004 due to franchise activity exceeding franchise payments in the 2005 period, compared to the 2004 period in which franchisepayments exceeded franchise activity.  This change was partially offset by a decrease in accounts receivable in the nine months ended September 30, 2005 compared to an increase in accounts receivable in the nine months ended September 30, 2004, due to lower revenue and the impact of franchise study activity, which is largely prepaid.

For the nine months ended September 30, 2005, our investing activities used cash of $21.9 million compared to $21.4 million during the nine months ended September 30, 2004.  The change was primarily the result of net activity related to short-term investments, which used $11.0 million of cash for the nine months ended September 30, 2005, compared to $9.4 million for the nine months ended September 30, 2004. This increased use of cash was partially offset by a $1.2 million decrease in cash used for purchases of property and equipment. 

During the nine months ended September 30, 2005, we capitalized $10.8 million of property and equipment compared to $12.0 million capitalized during the nine months ended September 30, 2004. The decrease was primarily the result of a decrease in purchases of ECG equipment, particularly equipment used in Thorough QTc studies, and software purchased in 2004 used in the development of the upgrade to EXPeRT® as discussed below. 

Included in property and equipment is internal use software associated with the development of a data and communications management services software product (EXPeRT®) used in connection with our centralized core cardiac safety ECG services. We capitalize certain internal use software costs in accordance with Statement of Position 98-1. The amortization is charged to the cost of Cardiac Safety services beginning at the time the software is ready for its intended use. The initial development costs of EXPeRT® were for the basic functionality required for this product. Additional development costs of EXPeRT® were incurred to develop new functionalities and enhancements. Westarted a new internal use software project to allow for semi-automated processing of ECGs in the second quarter of 2003 and further enhancements were begun in October 2004. We also began capitalizing costs associated with an upgrade to EXPeRT® (EXPeRT® 2) beginning in the fourth quarter of 2003.  In April 2005, we began developing enhancements to EXPeRT® which are necessary while EXPeRT® 2 continues to be developed. 

In mid-August of 2004, we revised our estimated timing for the completion of EXPeRT® 2 to continue the development work through the fourth quarter of 2005, as opposed to the first quarter of 2005 as we previously had estimated. As this upgrade will replace many parts of the existing EXPeRT® product, we previously had accelerated the amortization of capitalized labor and consulting costs to fully amortize the associated costs of the existing EXPeRT® product by the end of the first quarter of 2005, which increased monthly amortization expense by $76,000 beginning in the fourth quarter of 2003. Beginning in mid-August of 2004, we revised the amortization period for previouslycapitalized labor and consulting costs to fully amortize the associated costs of the existing EXPeRT® product by the end of the fourth quarter of 2005, which decreased monthly amortization expense by $76,000 beginning in mid-August 2004.  At the beginning of April 2005, we extended the life of the existing EXPeRT® product to co-exist with EXPeRT® 2 and extended the depreciation period through August 2006 which coincides with our standard useful life for internal use software of four years.  This resulted in a decrease in monthly amortization expense of $32,000 beginning in April 2005.

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The following table presents the internal use software costs and related amortization as of September 30, 2005 (in thousands):
      Related  Total        Amortization Labor and  Direct Costs Capitalized  Monthly  Accumulated  Start Date Consulting of Materials Costs Amortization Amortization        EXPeRT®                 Initial costsAugust 2002 $          2,618  $          1,413  $          4,031  $              55  $           3,475  Additional costsApril 2003            1,003                  50             1,053                 13                 910  Additional enhancementsOctober 2005               456   —               456   —  —                   Semi-automated ECG processing software                 Initial costsFebruary 2004               449                361                810                 17                 338  EnhancementsOctober 2004               380   —               380                   8                   96  Additional enhancementsApril 2005               376   —               376                   8                   48                    Upgrade to EXPeRT®September 2006 (estimated)           4,141            1,139            5,280  — —         Total  $          9,423  $          2,963  $        12,386  $            101  $           4,867          
For the nine months ended September 30, 2005, our financing activities used cash of $8.5 million compared to $4.0 million for the nine months ended September 30, 2004. The change was primarily the result of lower net proceeds from the exercise of stock options in the 2005 period as compared to the 2004 period as well as the repurchase of more common stock for treasury under our stock buy-back program in the 2005 period as compared to the 2004 period.

We have a line of credit arrangement with Wachovia Bank, National Association totaling $3.0 million. For the nine months ended September 30, 2005, we had no borrowings under the line.  

We have a commitment to purchase approximately $5.0 million of private label cardiac safety equipment from a manufacturer over the twelve-month period ending in July 2006.  This cardiac safety equipment was expected to be purchased in the normal course of business and thus does not represent a significant commitment above our expected purchases of ECG equipment during that period.  

We expect that existing cash and cash equivalents, short-term investments, cash flows from operations and available borrowings under our line of credit will be sufficient to meet our foreseeable cash needs for at least the next year. However, there may be acquisition and other growth opportunities that require additional external financing and we may from time to time seek to obtain additional funds from the public or private issuances of equity or debt securities. There can be no assurance that any such acquisitions will occur or that such financings will be available or available on terms acceptable to us.  

In the second quarter of 2005, the stock buy-back program that was originally announced in April 2004 and extended to 2.5 million shares in October 2004, was extended by an additional 10 million shares to a total of 12.5 million shares.  The purchase of a majority of the shares authorized could require us to use a significant portion of our cash, cash equivalents and short-term investments and could also require us to seek additional external financing.  The stock buy-back authorization allows us, but does not require us, to purchase the authorized shares.  During the third quarter of 2005, we purchased 479,600 shares of our common stock at a cost of $7.2 million.

**Inflation**

We believe the effects of inflation and changing prices generally do not have a material adverse effect on our results of operations or financial condition.

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**Item 3. Quantitative and Qualitative Disclosures About Market Risk**

Our primary financial market risks include fluctuations in interest rates and currency exchange rates.

**Interest Rate Risk**

We generally place our investments in money market funds, municipal securities, bonds of government sponsored agencies, certificates of deposit with fixed rates with maturities of less than one year, and A1P1 rated commercial bonds and paper. We actively manage our portfolio of cash equivalents and short-term investments, but in order to ensure liquidity, will only invest in instruments with high credit quality where a secondary market exists. We have not held and do not hold any derivatives related to our interest rate exposure. Due to the average maturity and conservative nature of our investment portfolio, a sudden change in interest rates would not have a material effect on the valueof the portfolio. Management estimates that had the average yield of our investments decreased by 100 basis points, our interest income for the nine months ended September 30, 2005 would have decreased by approximately $525,000. This estimate assumes that the decrease occurred on the first day of 2005 and reduced the yield of each investment by 100 basis points. The impact on our future interest income of future changes in investment yields will depend largely on the gross amount of our cash, cash equivalents and short-term investments. See “Liquidity and Capital Resources” as part of Management’s Discussion and Analysis of Financial Condition and Results of Operations.

**Foreign Currency Risk**

We operate on a global basis from locations in the United States and the United Kingdom. All international net revenues are billed and expenses incurred in either U.S. dollars or pounds sterling. As such, we face exposure to adverse movements in the exchange rate of the pound sterling. As the currency rate changes, translation of the statement of operations of our UK subsidiary from the local currency to U.S. dollars affects year-to-year comparability of operating results. We do not hedge translation risks because any cash flows from UK operations are generally reinvested in the UK.

Management estimates that a 10% change in the exchange rate of the pound sterling would have impacted the reported operating income for the nine months ended September 30, 2005 by approximately $170,000. 

**Item 4. Controls and Procedures**

We carried out an evaluation, under the supervision and with the participation of our management, including our Chief Executive Officer and Chief Financial Officer, of the effectiveness of our disclosure controls and procedures pursuant to Rule 13a-15 under the Securities Exchange Act of 1934, as amended, as of September 30, 2005.  Based upon that evaluation, our Chief Executive Officer and Chief Financial Officer concluded that our disclosure controls and procedures are effective to ensure that information required to be disclosed by our Company (including our consolidated subsidiaries) in our periodic filings with the Securities and Exchange Commission is recorded, processed, summarized and reportedwithin the time periods specified in the Commission’s rules and forms.  There has been no change in our internal control over financial reporting during the quarter ended September 30, 2005 that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.

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**Part II. Other Information**

**Item 2. Unregistered Sales of Equity Securities and Use of Proceeds**

We announced on May 3, 2005 that our Board of Directors authorized the purchase of up to an additional 10 million shares of our common stock, which extended the stock buy-back program previously announced to authorize the repurchase of a total of 12.5 million shares.  The current stock buy-back program was originally announced in April 2004 and extended to 2.5 million shares in October 2004.  Through September 30, 2005, we have repurchased 2.7 million shares of the 12.5 million shares approved for repurchase.  The following table provides information regarding the stock buy-back activity during the third quarter of 2005:
**ISSUER PURCHASES OF EQUITY SECURITIES**            **Period** **(a) Total Number of Shares Purchased**  **(b) Average Price Paid per Share** **(c) Total Number of Shares Purchased as Part of Publicly Announced Plans or Programs** **(d) Maximum Number of Shares that May Yet Be Purchased Under the Plans or Programs**       July 2005 —  $ — —                      10,295,000             August 2005                     479,600   $                   14.97                        479,600                        9,815,400             September 2005 —  $ — —                       9,815,400             Total                     479,600   $                   14.97                        479,600    
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**Item 6.  Exhibits**
10.10 2005 Amended Bonus Plan    31.1 Certification of Chief Executive Officer.   31.2 Certification of Chief Financial Officer.    32.1 Statement of Chief Executive Officer Pursuant to Section 1350 of Title 18 of the United States Code.   32.2 Statement of Chief Financial Officer Pursuant to Section 1350 of Title 18 of the United States Code.
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 Signatures

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.
       eResearchTechnology, Inc.   (Registrant)        Date:  November 3, 2005By:  Joseph A. Esposito   Joseph A. Esposito   President and Chief Executive Officer,       Director (Principal executive officer)        Date:  November 3, 2005By:  Bruce Johnson   Bruce Johnson   Senior Vice President and Chief Financial       Officer (Principal financial and      accounting officer)
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**EXHIBIT INDEX**
**Exhibit No.** **Exhibit**   10.10 2005 Amended Bonus Plan    31.1 Certification of Chief Executive Officer.   31.2 Certification of Chief Financial Officer.   32.1 Statement of Chief Executive Officer Pursuant to Section 1350 of Title 18 of the United States Code.   32.2 Statement of Chief Financial Officer Pursuant to Section 1350 of Title 18 of the United States Code.
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