Exhibit
4.19


 


LOCK-UP
AND VOTING AGREEMENT


 


This
Lock-Up and Voting Agreement (this “Lock-Up and Voting Agreement”) is being delivered to you in connection
with an understanding by and between Hancock Jaffe Laboratories, Inc., a Delaware corporation (the “Company”),
and the person or persons named on the signature pages hereto (collectively, the “Holder”).


 


Reference
is hereby made to the public offering (the “Offering”) of securities of the Company, including shares (“Shares”)
of common stock, par value $0.00001 per share, of the Company (the “Common Stock”) pursuant to the registration
statement on Form S-1 (File No. 333-239658) (“Registration Statement”). The Company is requiring a lock-up
and voting agreement in substance the same as this Lock-Up and Voting Agreement from all purchasers of Shares in the Offering
(each, a “Purchaser”).


 


The
Holder agrees solely with the Company that, from the public announcement of the final pricing of the Offering (the “Effective
Date”) and ending at 5:00 pm (New York City time) on July [  ], 2020 (such date, the “Closing Date”
and such period, the “Restricted Period”), neither the Holder, nor any affiliate of the Holder (“Affiliate”)
which (x) had or has knowledge of the transactions contemplated by the Offering, (y) has or shares discretion relating to the
Holder’s investments or trading or information concerning the Holder’s investments, including in respect of the Shares,
or (z) is subject to the Holder’s review or input concerning such Affiliate’s investments or trading (together, the
“Holder’s Trading Affiliates”), collectively, shall sell, dispose or otherwise transfer, directly or
indirectly, (including, without limitation, any sales, short sales, swaps or any derivative transactions that would be equivalent
to any sales or short positions) on any trading day on the primary trading market of the Company during the Restricted Period,
shares of Common Stock, including the Shares, beneficially owned by the Holder during the Restricted Period.


 


Additionally,
the Holder agrees to vote all shares of Common Stock it beneficially owns on and after the Closing Date, including the Shares,
in favor of all of the proposals presented to the stockholders of the Company, as described in the Company’s preliminary
proxy statement filed on Schedule 14A, as filed with the U.S. Securities and Exchange Commission on July [  ], 2020.


 


Notwithstanding
anything herein to the contrary, during the Restricted Period, the Holder may, directly or indirectly, sell or transfer all, or
any part, of the Restricted Shares to any third party (an “Assignee”) in a transaction which does not need
to be reported on the Nasdaq consolidated tape, without complying with (or otherwise limited by) the restrictions set forth in
this Lock-Up and Voting Agreement; provided that, as a condition to any such sale or transfer an authorized signatory of the Company
and such Assignee duly execute and deliver a Lock-Up and Voting Agreement in the form of this Lock-Up and Voting Agreement (an
“Assignee Agreement”, and each such transfer, a “Permitted Transfer”).


 


Any
notices, consents, waivers or other communications required or permitted to be given under the terms of this Lock-Up and Voting
Agreement must be in writing and shall be delivered to the Holder at the e-mail address or facsimile number on the signature page
hereto.


 


This
Lock-Up and Voting Agreement constitutes the entire agreement among the parties hereto with respect to the subject matter hereof
and supersedes all prior negotiations, letters and understandings relating to the subject matter hereof and are fully binding
on the parties hereto.


 




    	 



     


    

 


This
Lock-Up and Voting Agreement may be executed simultaneously in any number of counterparts. Each counterpart shall be deemed to
be an original, and all such counterparts shall constitute one and the same instrument. This Lock-Up and Voting Agreement may
be executed and accepted by facsimile or PDF signature and any such signature shall be of the same force and effect as an original
signature.


 


The
terms of this Lock-Up and Voting Agreement shall be binding upon and shall inure to the benefit of each of the parties hereto
and their respective successors and assigns.


 


This
Lock-Up and Voting Agreement may not be amended or modified except in writing signed by each of the parties hereto.


 


All
questions concerning the construction, validity, enforcement and interpretation of this Lockup and Voting Agreement shall be governed
by and construed and enforced in accordance with the internal laws of the State of New York, without regard to the principles
of conflicts of law thereof.


 


Each
party hereto acknowledges that, in view of the uniqueness of the transactions contemplated by this Lock-Up and Voting Agreement,
the other party or parties hereto will not have an adequate remedy at law for money damages in the event that this Lock-Up and
Voting Agreement has not been performed in accordance with its terms, and therefore agrees that such other party or parties shall
be entitled to seek specific enforcement of the terms hereof in addition to any other remedy it may seek, at law or in equity.


 


The
obligations of the Holder under this Lock-Up and Voting Agreement are several and not joint with the obligations of any other
holder of any of the Shares issued under the Registration Statement (each, an “Other Holder”), and the Holder
shall not be responsible in any way for the performance of the obligations of any Other Holder under any such other agreement.
Nothing contained in this Lock-Up and Voting Agreement, and no action taken by the Holder pursuant hereto, shall be deemed to
constitute the Holder and Other Holders as a partnership, an association, a joint venture or any other kind of entity, or create
a presumption that the Holder and the Other Holders are in any way acting in concert or as a group with respect to such obligations
or the transactions contemplated by this Lock-Up and Voting Agreement and the Company acknowledges that the Holder and the Other
Holders are not acting in concert or as a group with respect to such obligations or the transactions contemplated by this Lock-Up
and Voting Agreement or any other agreement. The Company and the Holder confirm that the Holder has independently participated
in the negotiation of the transactions contemplated hereby with the advice of its own counsel and advisors. The Holder shall be
entitled to independently protect and enforce its rights, including, without limitation, the rights arising out of this Lock-Up
and Voting Agreement, and it shall not be necessary for any Other Holder to be joined as an additional party in any proceeding
for such purpose.


 


The
Company hereby represents and warrants as of the date hereof and covenants and agrees from and after the date hereof that none
of the terms offered to any Other Holder with respect to any restrictions on the sale of Shares substantially in the form of this
Lock-Up and Voting Agreement (or any amendment, modification, waiver or release thereof) (each an “Other Agreement”),
is or will be more favorable to such Other Holder than those of the Holder and this Lock-Up and Voting Agreement, and the Company
agrees to use reasonable best efforts to enforce the terms of any Other Agreement. If, and whenever on or after the date hereof,
the Company enters into an Other Agreement with terms that are materially different from this Lock-Up and Voting Agreement, then
(i) the Company shall provide notice thereof to the Holder promptly following the occurrence thereof and (ii) the terms and conditions
of this Lock-Up and Voting Agreement shall be, without any further action by the Holder or the Company, automatically amended
and modified in an economically and legally equivalent manner such that the Holder shall receive the benefit of the more favorable
terms and/or conditions (as the case may be) set forth in such Other Agreement; provided that, upon written notice to the Company,
at any time the Holder may elect not to accept the benefit of any such amended or modified term or condition, in which event the
term or condition contained in this Lock-Up and Voting Agreement shall apply to the Holder as it was in effect immediately prior
to such amendment or modification as if such amendment or modification never occurred with respect to the Holder. The provisions
of this paragraph shall apply similarly and equally to each Other Agreement.


 


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remainder of the page is intentionally left blank]


 




    	 



     


    







 


The
parties hereto have executed this Lock-Up and Voting Agreement as of the date first set forth above.


 


	HANCOCK JAFFE LABORATORIES, INC.	 
	 	               	 
	By:	 	 
	Name:	 	 
	Title:	 	 
	E-mail:	 	 
	Facsimile:	 	 


 


[Signature
Page to HJLI Lock-Up and Voting Agreement]


 




    	 



     


    

 


The
parties hereto have executed this Lock-Up and Voting Agreement as of the date first set forth above.


 


	Agreed
    to and Acknowledged:
	 	        	 
	HOLDER	 
	 	 
	 	 	 
	By:	 	 
	Name:	 	 
	Title:	 	 
	E-mail:	 	 
	Facsimile:	 	 


 


[Signature
Page to HJLI Lock-Up and Voting Agreement]