**Exhibit 3.1**

** **

**The Commonwealth of Massachusetts**

**William Francis Galvin**

Secretary of theCommonwealth

One Ashburton Place,Boston, Massachusetts 02108-1512

 

**Articles of Amendment**

**(General Laws, Chapter 156D;Section 10.06; 950 CMR 113.33)**

** **
| Exact name of corporation:                     |   | **Boston  Biomedica, Inc.**                                                               | ** ** |
|------------------------------------------------|--------|-------------------------------------------------------------------------------------------|------------|
|                                           |   |                                                                                      |       |
| Registered office address:                     |   | **375  West Street, West Bridgewater, MA 02379**                                          | ** ** |
|                                           |   | *(number,  street, city or town, state, zip code)*                                        |       |
|                                           |   |                                                                                      |       |
| These articles of amendment affect article(s): |   | **One**                                                                                   | ** ** |
|                                           |   | *(specify  the number(s) of article(s) being amended (I-VI))*                             |       |
|                                           |   |                                                                                      |       |
| Adopted and approved on:                       |   | **April  16, 2004 by the Board of Directors and  September 14, 2004 by the shareholders** | by         |
|                                           |   | *(month,  day, year)*                                                                     |       |

 

 

Check the appropriate box below:

 
| o      |   | the incorporators.                                                                                           |
|--------|--------|--------------------------------------------------------------------------------------------------------------|
| o      |   | the board of directors without shareholder approval  and shareholder approval was not required.              |
| ý |   | the board of directors and the shareholders in the  manner required by law and the articles of organization. |

 

State the article number and the text of the amendment.  If the amendment authorizes an exchange, oreffects a reclassification or cancellation, of issued shares, state theprovisions for implementing the action unless contained in the text of theamendment.

 

 

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**Attachment Sheet**

** **

Articles of Amendment

 

Boston Biomedica, Inc.

 

 

 

ARTICLE I:  The name by which thecorporation shall be known:  PressureBioSciences, Inc.

 

 

 

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To change the number of shares and the par value (if any) of any type,or to designate a class or series, of stock, or change a designation of class orseries of stock, which the corporation is authorized to issue, complete thefollowing:

 

The total presently authorized is:

 
| WITHOUT PAR VALUE | WITH PAR VALUE   |
|-------------------|------------------|
| TYPE              | NUMBER OF SHARES | TYPE | NUMBER OF SHARES | PAR VALUE |
|              |             |   |   |   |
|              |             |   |   |   |
|              |             |   |   |   |

 

Change the total authorized to:

 
| WITHOUT PAR VALUE | WITH PAR VALUE   |
|-------------------|------------------|
| TYPE              | NUMBER OF SHARES | TYPE | NUMBER OF SHARES | PAR VALUE |
|              |             |   |   |   |
|              |             |   |   |   |
|              |             |   |   |   |

 

The foregoing amendment(s) will become effective when these Articles ofAmendment are filed in accordance with General Laws, Chapter 156D, §1.25 unlessthese articles specify, in accordance with the vote adopting the amendment alater effective date not more than ninety days after such filing, in whichevent the amendment will become effective on such later date.

 

 
| Later effective date: |   |   |
|-----------------------|--------|--------|

 

 

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| Signed by | /s/ Richard T. Schumacher |
|-----------|---------------------------|

 

*                (Pleasecheck appropriate box)*

* *

                o  Chairman ofthe Board

                ý  President

                o  Other Officer

                o Court-appointed fiduciary

 
| on this | 14th | day of | September | , | 2004 |
|---------|------|--------|-----------|---|------|

 

 

 

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THE COMMONWEALTH OFMASSACHUSETTS

 

I hereby certify that,upon examination of this document, duly submitted to me, it appearsthat the provisions of the General Laws relative to corporations have beencomplied with,and I hereby approve said articles; and the filing fee having been paid, saidarticles aredeemed to have been filed with me on:

September 14, 2004 4:21PM

 

 

 

| /s/ William Francis Galvin |
|----------------------------|

 

WILLIAM FRANCIS GALVIN

 

*Secretary of the Commonwealth*

 

 

 

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