**PROMISSORY NOTE**
**$450,000.00**
**Boston, Massachusetts**
**July 10, 2001**
**As amended on October 4, 2001**

        FORVALUE RECEIVED, the undersigned, Richard T. Schumacher, having an address at 349Foundry St., South Easton, MA 02375 (“Maker”), promises to pay to theorder of Boston Biomedica, Inc., a Massachusetts corporation having an addressat 375 West Street, West Bridgewater, MA 02379 the sum of FOUR HUNDRED FIFTYTHOUSAND ($450,000.00) DOLLARS together with interest on the unpaid balance atthe rate of seven (7.0%) percent per annum payable as to interest only on thefirst day of each month, and with the entire balance of accrued interest, ifany, and principal to be paid in full one (1) year from the date hereof (the“Maturity Date”). 

        As     of the date of this  Note,  the  Maker has  drawn  $250,000.00  of the faceamount of this Note. In addition,  the Maker has drawn an additional  $50,000 onAugust 30, 2001,  $50,000 on September 27, 2001, and $100,000 on October 4, 2001under this note. At the option of the Maker, Maker may satisfy his obligation tomake monthly payments of interest by instructing the holder to draw and pay suchmonthly interest  payments to the holder from the unadvanced face amount of thisNote,  provided  that the  holder  shall not have any  obligation  to advance orreadvance  any amount (i) in excess of the face amount of this Note,  or (ii) ifthere  exists an the event of a default  under this Note or any stock  pledge orother security instrument given therefor or in connection therewith. 

        Atthe option of the holder, the Maturity Date may be extended for one or moreadditional one year term(s). 

        TheMaker also agrees to pay all costs and expenses incurred by the holder hereof,including all reasonable attorneys’ fees for implementing this loan, or forthe collection of this Note and the indebtedness evidenced hereby, or theenforcement of the holder’s rights hereunder or under any other instrumentcreating any collateral security or guaranty now or hereafter given to securethis loan. 

        Atthe option of the holder, this Note shall become immediately due and payablewithout further notice or demand, and notwithstanding any prior waiver of anybreach or default or other indulgence, upon the occurrence at any time of anyone or more of the following events (“event of default”): (i) defaultcontinuing for ten (10) days in making any payment of principal, interest orother charges due hereunder; (ii) default continuing uncured for thirty (30)days under any security agreement now or hereafter executed in connection withthe indebtedness evidenced hereby (except that there shall be no grace period inrespect of a sale of any collateral or in respect of any bankruptcyproceedings); (iii) if any party liable hereon whether as maker, endorser,guarantor, surety or otherwise shall make an assignment for the benefit ofcreditors, or if a receiver of any such party’s property shall beappointed, or if a petition in bankruptcy or other similar proceeding under anylaw for relief of debtors shall be filed by or against any such party; (iv) if atax lien is filed against the Maker, or against any property which is collateralfor this Note, and the same is not discharged within thirty (30) days; (v) inthe event of any sale or transfer of any real or personal property comprisingcollateral for this Note; and (vi) if the Maker shall fail to pay or perform anyobligations secured by any senior security interest affecting any collateralgiven to secure this Note. 

        Eachand every party liable hereon whether as maker, endorser, guarantor, surety orotherwise hereby: (a) waives presentment, demand, protest, suretyship defensesand defenses in the nature thereof; (b) waives any defenses based upon andspecifically assents to any and all extensions and postponements of the time forpayment, changes in terms and conditions and all other indulgences andforebearances which may be granted by the holder to any party now or hereafterliable hereunder; (c) agrees to any substitution, exchange, release, surrenderor other delivery of any collateral now or hereafter held hereunder and to theaddition or release of any other party or person primarily or secondarilyliable; and (d) agrees to be bound by all of the terms contained in this Noteand in any stock pledge agreement, security agreement, mortgage and all otherinstruments now or hereafter executed, evidencing or governing all or anyportion of the collateral for this Note. Every such party to this Note and eachsuch instrument agrees that the obligations of all such parties shall be jointand several. 

        Nodelay or omission on the part of the holder in exercising any right hereunder orany right under any instrument or agreement executed in connection herewithwhich is given or may be given to secure the indebtedness evidenced hereby shalloperate as a waiver of such right, or of any other right, of such holder, norshall any delay, omission or waiver on any one occasion be deemed to be a barto, or waiver of, the same or of any other right on any future occasion. 

        Duringthe period of any event of default, and after maturity (which shall mean thedate stated above on which the entire balance of principal and interest is dueand payable hereunder, or such earlier date on which the entire sum may becomedue and payable at the option of the holder following default as set forthabove) this Note shall bear interest at the rate of eighteen percent (18%) perannum. 

        Notwithstandingany provision contained herein or contained in any stock pledge, securityagreement or other instrument or agreement now or hereafter executed inconnection with this Note, the maximum amount of interest and other charges inthe nature thereof contracted for, or payable hereunder or thereunder, shall notexceed the maximum amount which may be lawfully contracted for, charged andreceived in this loan transaction all as determined by the final judgment of acourt of competent jurisdiction, including all appeals therefrom. 

        Allpayments due hereunder shall be made Boston Biomedica, Inc., 375 West Street,West Bridgewater, MA 02379, ATTENTION: Treasurer, or such other place as theholder hereof may designate from time to time in writing. 

```

      Executed as a sealed instrument.

 WITNESS:

 ____________________________                            ______________________________
                                                         Richard T. Schumacher
```

*** * * * * * * * * * * * * ***
**This Note is secured by the pledge of 90,000 shares of common stock of Boston Biomedica, Inc., a Massachusetts corporation.**
*** * * * * * * * * * * * * ***