EXHIBIT 10.3
                            
                           AMENDED AND RESTATED
                      MICRONIZED GLYBURIDE AGREEMENT


          THIS AMENDED AND RESTATED MICRONIZED GLYBURIDE AGREEMENT (the 
"Agreement"), effective this 1st day of January, 1997 (the "Effective Date"), 
is by and between HOECHST MARION ROUSSEL, INC., a Delaware corporation 
("HMRI"), and COPLEY PHARMACEUTICAL, INC., a Delaware corporation ("COPLEY").

W I T N E S S E T H:

          WHEREAS, HMRI is engaged in the manufacture, for the United States 
of America market, of micronized glyburide in finished dosage forms (the 
"Product" or "Products") pursuant to New Drug Application #20-055 (the "NDA"), 
and

          WHEREAS, COPLEY desires to purchase and market the Products, under 
its own name and under the private label name of certain of COPLEY's customers 
in the Territory (as hereinafter defined), and

          WHEREAS, HMRI desires to supply Product to COPLEY, upon the terms 
and conditions provided herein.

          WHEREAS, COPLEY and HMRI are parties to that certain Micronized 
Glyburide Agreement dated as of December 21, 1994 (the "Micronized Glyburide 
Agreement") and the parties wish to amend and restate the Micronized Glyburide 
Agreement to include certain new agreements between HMRI and COPLEY.

          NOW THEREFORE, the parties hereto agree as follows:

1.   MANUFACTURE, PURCHASE AND SALE OF PRODUCT, AND HMRI REVENUE SHARE

     1.1  Purchase and Sale.  Pursuant to the terms and conditions of this 
Agreement consistent with 21 CFR 314.70(d)(4), HMRI agrees to manufacture 
exclusively for COPLEY, during the Term (as defined in Section 11.1 hereof) of 
this Agreement, the 1.50 mg and 3.00 mg strengths of HMRI's micronized 
glyburide formulation, for sale by COPLEY to the trade in the Territory under 
the COPLEY label and the private label of certain of COPLEY's customers.  For 
the Term, and thereafter in the event of renewal or extension (as set forth in 
Section 11 hereof), COPLEY agrees to purchase all of its requirements for the 
Product for sale in the Territory from HMRI and HMRI agrees to supply all of 
COPLEY's requirements for the Product.  It is understood by the parties that 
the Product is produced in campaigns of a minimum quantity set forth in 
Schedule 1.1 of this Agreement (the "Minimum Quantity").  Regardless of 
COPLEY's requirements under this Section 1.1, COPLEY hereby agrees to place
firm and binding orders for, and to purchase and take delivery from HMRI of, 

<PAGE 2>>

quantities of the Product and any multiples thereof to be delivered to COPLEY 
in each calender month during the Term of this Agreement that are not less 
than the Minimum Quantity.  The parties acknowledge that shipments of the 
Product by HMRI may vary from the Minimum Quantity by up to ten percent more 
or less than the Minimum Quantity.

   1.2  Product Specifications and Manufacturing Technology Transfer Option.  
HMRI will manufacture the Product for COPLEY in oblong, scored tablets in 
strengths and colors as follows:

                  STRENGTH:                      COPLEY GENERIC:

                  3.00  mg                            green
                  1.50  mg                            pink

       The Product shall meet the specifications set forth in the NDA, as such 
specifications may be changed from time to time.  HMRI shall on a timely basis 
advise COPLEY of any changes made with respect to the NDA.

   1.3  Labeling and Packaging.  Packaging and labeling for the Product  shall 
be consistent with the U.S. Food and Drug Administration (the "FDA") approved 
labeling for the Products, and shall be in dosage strengths and colors as set 
forth in Section 1.2 herein and in packaging configurations as subsequently 
mutually agreed upon by the parties.

   1.4  Rolling Forecasts and Orders.  On a monthly basis COPLEY will provide 
HMRI with 12-month rolling forecasts by package size (SKU) and by distributor.  
The first rolling forecast will be due upon execution of this Agreement.

          COPLEY will be obligated to place orders and purchase from HMRI the 
following:

       a.  100% of the amounts forecast for the first three months of each 
rolling forecast; and

       b.  50% of the amounts forecast for months four, five and six of each 
rolling forecast.

          Each purchase order shall contain a shipment date in accordance with 
HMRI's manufacturing lead time of twelve (12) weeks, and be subject to the 
provisions of Section 9 hereof.  COPLEY will supply HMRI with monthly sales 
summaries by class of trade at HMRI's request.

   1.5  Cost of Goods and Payment.  Annually in January of each calendar year 
during the Term of this Agreement, HMRI shall provide to COPLEY cost of goods 
pricing for the Products during that calender year.  HMRI cost of goods 
pricing provided to COPLEY for each calendar year subsequent to the initial 
pricing provided in Exhibit A of this Agreement shall be accompanied by such 

<PAGE 3>

reasonable detail and documentation as to enable COPLEY to understand the 
basis for such pricing.  The pricing shall include material costs (including, 
but not limited to, bulk active ingredient costs which bulk active costs shall 
include a reasonable profit margin to HMRI to be negotiated based upon quotes 
from qualified, bona fide sources), manufacturing charges and packaging costs 
on a fully allocated basis according to generally accepted accounting 
principles.  HMRI's cost of goods pricing to COPLEY during 1997 for packaged
finished goods FOB Bridgewater, New Jersey shall be as set forth in Exhibit A, 
attached hereto and made a part hereof.  Notwithstanding the foregoing
sentence, the parties understand that HMRI may move its production site for 
any Product to a different site and that in such event Exhibit A of this 
Agreement will be amended to reflect HMRI's cost of goods pricing to COPLEY at 
such new production site.  COPLEY agrees to pay the invoice amount for the 
Products ordered by COPLEY.  Terms of payment shall be open account, net 
forty-five (45) days from the later of receipt of invoice or shipment of the 
Product.

   1.6  Advertising/Marketing/Sales Costs and Product Pricing.  COPLEY shall 
be responsible for all advertising, marketing and sales costs associated with 
Product distribution.  COPLEY will have complete authority for all pricing 
decisions for the Product sold by COPLEY.  COPLEY agrees to keep HMRI 
reasonably informed of price changes in excess of twenty-five percent (25%) or 
such other percentage as mutually agreed to by the parties.

   1.7  HMRI Net Profit Margin Share.  The parties agree that HMRI shall 
receive, on a monthly basis, payments from COPLEY which shall be equal to 
[*] of the COPLEY Net Profit Margin realized on sales of any Product in the 
Territory during each preceding calendar month.  For the purposes of this 
Section 1.7, COPLEY Net Profit Margin shall mean COPLEY Product gross sales 
less actual chargebacks, rebates, price adjustments, returns and cash 
discounts and less cost of goods as set forth in Section 1.5 herein.  Exhibit 
B, attached hereto and made a part hereof, sets forth the method of 
calculation of HMRI Net Profit Margin Share.  The monthly payments contemplated 
by this Section 1.7 shall be made by check delivered to HMRI not 
later than ninety (90) days following the close of each calendar month during 
the Term of this Agreement.

   1.8  Commercialization Fee.  In consideration of services or activities 
performed or rendered by HMRI in connection with commercialization of the 
Product, COPLEY agrees to pay HMRI $[*] upon execution of this Agreement.

2.  TERRITORY

    This Agreement encompasses only the United States of America and its 
possessions and territories including Puerto Rico (the "Territory") and gives 
COPLEY the right to market to all classes of trade in the Territory.


[*] Confidential portion has been omitted pursuant to a request for 
confidential treatment and has been filed separately with the Commission.


<PAGE 4>


3.  REGULATORY MATTERS

   3.1  FDA Approval.  HMRI represents and warrants that the Product is 
approved by the FDA for the uses set forth in HMRI's labeling.  COPLEY and 
HMRI agree to take all necessary action to obtain and maintain any approvals 
necessary to permit COPLEY to sell the Product under its own name in the 
Territory in compliance with applicable federal and state drug laws.  HMRI and 
COPLEY agree to coordinate with each other concerning all changes to Product 
labeling.

   3.2  Regulatory Correspondence.  COPLEY and HMRI shall make available to 
each other, within three (3) days of receipt, regulatory correspondence 
covering the following issues:  regulatory letters, Product recalls, 
withdrawal of Product, and correspondence bearing on the safety and efficacy 
of the Product.

   3.3  Product Inquiries and Complaints/Recalls.  COPLEY will promptly submit 
to HMRI all Product safety and efficacy inquiries, Product quality complaints 
and adverse drug event (ADE) reports received by it, together with all 
available evidence and other information relating thereto.  Except as 
otherwise required by law or governmental regulation, HMRI will be responsible 
for investigating and responding to all such inquiries, complaints and adverse 
events regarding the Product.  It shall be the exclusive responsibility of 
HMRI to comply with all federal, state and local governmental reporting 
requirements regarding ADEs and Product quality matters, except where such 
events or matters are caused solely by acts or omissions of COPLEY, in which 
case HMRI may, consistent with applicable law and regulation, request COPLEY's 
assistance in such compliance.  HMRI will forward a copy of all FDA 
submissions concerning Product ADEs or any Product safety-related topic to 
COPLEY within ten (10) working days of submission.  In the event of a dispute 
in respect of the therapeutic action or quality of the Product:  (i) if the 
dispute involves only COPLEY and a subsequent purchaser then COPLEY and HMRI 
shall consult prior to any compromise or settlement of such dispute; and (ii)
if the dispute involves COPLEY, HMRI and a subsequent purchaser then both 
parties must consent prior to any compromise or settlement of such dispute. 
COPLEY shall be responsible for forwarding recall materials received from HMRI 
designed to recover Products distributed by it and its private label customers 
in the event of a recall.  Expenses associated with a recall are to be borne 
by the party at fault.

   3.4  Quality Assurance.  In order to facilitate quality assurance 
activities with respect to the Product, HMRI agrees to (a) allow COPLEY at 
least once per year at mutually agreeable times to inspect/audit HMRI's 
facilities and records pertaining to manufacture, testing, storage and 
packaging for compliance with Good Manufacturing Practice, 21 CFR 211, and (b) 
supply to COPLEY the results of all stability testing for the Product.  COPLEY 
agrees to allow HMRI at least once per year at mutually agreeable times to 
inspect/audit COPLEY's facilities and records pertaining to storage and 
distribution for compliance with Good Manufacturing Practice, 21 CFR 211.


<PAGE 5>

   3.5  Additional Information.  COPLEY shall provide to HMRI in a timely 
manner, but in no event less than thirty (30) days prior to the due date of 
HMRI's annual report to the FDA with respect to the Product, all information
 which HMRI requests regarding the Product in order to comply with applicable 
federal and state drug laws.  Such information shall include, without 
limitation, quantities of the Product sold.  COPLEY shall be responsible for 
assuring that all promotional material produced by it relating to the Product 
comply with federal, state and local law.  COPLEY shall provide to HMRI prior 
to first use copies of all advertising, promotional material, labeling and 
other literature used on, or in connection with, the Product.  HMRI shall 
supply to COPLEY on a timely basis a copy of said FDA annual report.

4.  PROPRIETARY RIGHTS AND TRADEMARKS

    HMRI retains ownership of the NDA and any supplements thereto.  HMRI is 
the owner of certain proprietary information (the "Proprietary Rights") used 
in connection with the manufacturing, sale and distribution of micronized 
glyburide pharmaceutical preparations.  No such Proprietary Rights are being 
assigned, licensed or otherwise transferred hereunder, and COPLEY acknowledges 
that it shall have no rights hereunder to any such Proprietary Rights and 
hereby agrees that it shall not contest or dispute the validity of or title to 
any of such Proprietary Rights.  Without limiting the generality of the 
foregoing, COPLEY agrees it shall not take or cooperate in litigation or 
threatened litigation which might or is intended to impair or attack such 
Proprietary Rights or which questions the paramount interest of HMRI or its
affiliates, licensees or assignees in the same.  COPLEY and its private label 
customers shall market the Product under their own trade names and trademarks, 
which shall not be confusingly similar to the trademark of HMRI for its 
micronized glyburide product.

5.  SECRECY

    Except for literature and information intended for disclosure to 
customers, each party will treat as confidential all technical and commercial 
information acquired by it from the other party under this Agreement and will 
take all necessary precautions to assure the secrecy of such confidential 
information.  Each party agrees to return to the other party upon the 
expiration or termination of this Agreement all confidential technical and 
commercial literature, data, and information acquired from the other party.  
Neither party shall, during the term of this Agreement or for ten (10) years 
thereafter, without the express prior written consent of the other party, use
or disclose any such information received by it from the other party pursuant 
to the transactions contemplated by this Agreement for any purpose whatsoever.

6.  WARRANTY

    HMRI warrants that the Product manufactured by HMRI and sold to COPLEY 
pursuant to this Agreement will meet the specifications for the Product set
forth in the NDA in effect at the time of such shipment.  HMRI reserves the 
right to amend such specifications from time to time at the sole discretion of 
HMRI; provided that COPLEY is provided with written notice within a 

<PAGE 6>

commercially reasonable period of time in advance in order to effect any 
necessary marketing or other changes.  All Products will conform to, and the 
Products manufactured by HMRI will be manufactured in conformity with, the 
regulations of the Federal Food and Drug Administration and any comparable 
state agency applicable thereto.  None of the Product contained in any 
shipment made hereunder to COPLEY will, at the time of delivery, be 
adulterated or misbranded within the meaning of the Federal Food, Drug and 
Cosmetic Act, as amended (the "Act"), and those applicable state laws 
substantially similar to the Act, as such Act and laws exist at the time of
delivery.  None of the Products will be an article that may not, under the 
provisions of the Act, be introduced into interstate commerce.  The Products 
shall conform with any specifications and quality assurance requirements 
mutually agreed to in writing by the parties and, in any event, shall not 
contain any poisonous or deleterious material.  No Product shall infringe the 
patent, trade secret or other proprietary right of any third party.  THIS 
WARRANTY IS THE ONLY WARRANTY, EXPRESS OR IMPLIED, MADE BY HMRI AS TO THE 
PRODUCT, AND ALL OTHER WARRANTIES, INCLUDING MERCHANTABILITY OR FITNESS FOR 
ANY PARTICULAR PURPOSE, ARE DISCLAIMED.  Except as otherwise provided in this
Agreement, the exclusive remedy for breach of warranty shall be prompt 
replacement of the nonconforming Product at HMRI's expense with a like amount 
of the Product conforming to the above-stated warranty.  For purposes hereof, 
replacement may include reprocessing of the Product if done in a period of 
time commercially reasonable to COPLEY.  In no event shall HMRI be liable to 
COPLEY for any alteration, change, improper packaging or other improper 
treatment of the Product by COPLEY other than in accordance with HMRI's 
instructions; nor shall HMRI be liable to COPLEY for any damage arising solely 
from COPLEY's marketing, advertising, distribution or sale of the Product that 
conforms to the warranty set forth above.

7.  COPLEY'S OBLIGATIONS

    COPLEY shall not alter the Product and shall not recommend or knowingly 
sell the Product for any uses except as described in the FDA approved Product 
labeling.

8.  INDEMNITY

   8.1  Indemnification by HMRI.  HMRI shall defend, indemnify and hold 
harmless COPLEY and its affiliates (and each of their employees, officers, 
directors and stockholders) from and against any and all claims, liabilities, 
assessed damages, costs and expenses (including, without limitation, costs and
expenses of investigation and settlement, court costs and attorneys' fees and 
expenses regardless of outcome, but excluding any indirect, incidental or 
consequential damages or losses and lost profits) arising out of any claim of
defect in materials or workmanship of the Product, failure of the Product to 
conform to the express warranty set forth in Section 6 hereinabove or alleged 
or actual personal injury, illness, death or other harm, except to the extent 
such claim arises out of COPLEY's breach of this Agreement, negligence or 
misconduct.


<PAGE 7>

   8.2  Indemnification by COPLEY.  COPLEY shall defend, indemnify and hold 
harmless HMRI and its affiliates (and each of their employees, officers, 
directors and stockholders) from and against any and all claims, liabilities, 
assessed damages, costs and expenses (including, without limitation, costs and
expenses of investigation and settlement, court costs and attorneys' fees and 
expenses regardless of outcome, but excluding any indirect, incidental or 
consequential damages or losses and lost profits) to the extent caused by 
COPLEY's packaging, marketing, advertising, distribution or sale of Product 
that conforms to the express warranty set forth in Section 6 hereinabove or 
caused by alterations to the Product made by COPLEY after delivery by HMRI 
other than in accordance with the written directions of HMRI, except to the 
extent such claim arises out of HMRI's breach of this Agreement, negligence or 
misconduct.

   8.3  Indemnification Procedures.  The parties shall cooperate and give each 
other prompt notice of claims as to which indemnification may be claimed 
hereunder.  The indemnifying party may, at its option, control the defense of 
claims for which indemnification may be sought.  The indemnifying party shall 
not be required to indemnify the indemnified party for any claim settled 
without the indemnifying party's written consent.

9.   ORDERS

   9.1  Placement of Orders.  All orders placed by COPLEY with HMRI hereunder 
shall be sent to the following address, unless otherwise notified in writing:

Hoechst Marion Roussel, Inc.
2110 East Galbraith Road
P.O. Box 156300
Cincinnati, OH  45215-6300
Attn:  Ronald R. Schallick
Telephone:  (513) 948-7197
Telecopy:  (513) 948-4547

   9.2  Shipment.  HMRI shall make every reasonable effort to fill COPLEY's 
accepted orders in accordance with COPLEY's requested delivery dates.  All 
shipments of the Product to COPLEY shall be accompanied by a certificate of 
analysis for each batch in said shipment, certifying that each batch was made 
in accordance with current Good Manufacturing Practices and the NDA and 
listing test results.  Deliveries to COPLEY shall be FOB, HMRI Bridgewater, 
New Jersey or such other U.S. location to which HMRI may move production of 
the Product.  COPLEY shall pay all shipping costs, including insurance.

   9.3  Risk of Loss.  Risk of loss shall pass to COPLEY upon shipment by 
HMRI.

   9.4  Claims.  COPLEY shall cause a commercially reasonable visual 
inspection of all shipments of the Product promptly after arrival if shipped 
directly to COPLEY, and shall give prompt oral notice of potential 
nonconforming goods, and within thirty (30) days after arrival of any such 

<PAGE 8>

shipment, give written notice to HMRI of any claim that any Product included 
in shipment may not conform to any applicable specifications or warranty.  If
shipment of the Product is to a destination other than COPLEY, any claims of 
non-conformity under this Section 9.4 must be made by COPLEY within ninety 
(90) days of actual delivery of the Product to such destination.  HMRI shall 
promptly replace such nonconforming Product with conforming Product at no 
additional cost to COPLEY.  COPLEY's failure to detect and/or give notice of 
any defect not readily identifiable upon commercially reasonable visual 
inspection shall not vitiate HMRI's obligations under the warranty and 
indemnification provisions of this Agreement.

10.  FORCE MAJEURE

    Neither party shall be responsible or liable, in any way, for any default 
in performance of this Agreement arising, directly or indirectly, from any 
cause beyond such party's control, including, without limiting the generality 
of this provision, fire, flood, tornado, cyclone, war, enemy action, embargo, 
strike, lockout, labor trouble, transportation difficulties, governmental 
order, proclamation or regulation, inability to obtain raw materials, fuel, 
power, packaging or other supplies, accident, explosion, riot, insurrection or
expropriation of the plants by governmental authority, or failure to make 
delivery of the Product if the same shall be prevented or delayed by state or 
other governmental authority or as a result of requisitioning for allocation 
to others by any governmental authority.

11.  TERM, TERMINATION AND BREACH

   11.1  Term.  The Term of this Agreement shall commence on the date first 
written above (the "Effective Date") and shall be in full force and effect 
until five (5) years from the Effective Date (such period being the "Initial 
Term") unless earlier terminated pursuant to Section 11.3 or 11.4 
(Termination).  This Agreement shall renew for subsequent five (5) year
periods following expiration of the Initial Term (each an "Additional Term"), 
under the same terms and conditions as the Initial Term, unless terminated by 
written notice by either party not later than three (3) years prior to the 
termination of any Initial Term or Additional Term hereunder.

    The period of time between the commencement and the termination of this 
Agreement at the end of the Initial Term or the last Additional Term, if any, 
is referred to herein as the "Term."

   11.2  Renegotiation.  If either party gives notice of termination pursuant 
to Section 11.1  or if HMRI gives notice of termination pursuant to Section 
11.3(ii) or Section 11.4, the parties shall, for a period of three months 
following such notice, negotiate in good faith the terms and conditions under 
which the Agreement could be renewed or continued, as the case may be.

          (i)  In the event that HMRI provides notice to terminate pursuant to 
this Section 11.1 or Section 11.4 and such renewal or continuation 
negotiations are unsuccessful, this Agreement shall be terminated as of the 
end of such three month negotiation period.  At COPLEY's written request, HMRI 
shall provide COPLEY or its designee with such technical assistance services 

<PAGE 9>

reasonably necessary to enable COPLEY to manufacture or have manufactured its 
own product versions of the Products pursuant to Abbreviated New Drug 
Applications of COPLEY (the "COPLEY Products") in the Territory; provided, 
however, that COPLEY shall have no right to (a) require HMRI to transfer to 
COPLEY or any third party any right whatsoever with respect to the NDA or the 
Proprietary Rights, (b) require HMRI to provide technical assistance services 
to any third party, or (c) transfer to any third party technical assistance 
services learned under this Agreement.  In consideration of these technical 
assistance services, HMRI shall receive a royalty of 20% of the COPLEY Net 
Profit Margin (as defined in Section 1.7 herein) with respect to sales by 
COPLEY of any COPLEY Product for a period of ten (10) years from the date of 
first commercial sale of such COPLEY Product.

          (ii)  In the event that COPLEY provides notice to terminate pursuant 
to this Section 11.1 and renewal negotiations are unsuccessful, HMRI shall 
have no obligation to provide COPLEY with any technical assistance services 
pursuant to this Agreement.

   11.3  Termination.

          (I)  Either party shall have the right to terminate this Agreement 
at any time by giving due notice to terminate this Agreement in any of the 
following events:

             (a)  Insolvency or bankruptcy of the other party or the inability 
or failure of the other party to perform any financial obligations as the same 
become due;

             (b)  Failure of the other party to make required payment under 
this Agreement where such failure continues after ten (10) days' notice from 
the other party;

             (c)  Demonstrable inability of the other party to perform its 
material obligations under this Agreement; and/or

             (d)  The enactment of any law, order or regulation by a 
governmental unit that would impair or restrict the right of or the ability of 
either party to terminate or elect not to renew this Agreement or which would 
render it impracticable or impossible for the  other party to perform its 
obligations hereunder.

          (ii)  Either party shall have the right to terminate this Agreement 
at any time upon six months' prior written notice if the COPLEY Net Profit 
Margin as defined in Section 1.7 has been negative for six consecutive months.


<PAGE 10>

   11.4  HMRI Termination.  This Agreement may be terminated at any time by 
HMRI upon written notice to COPLEY that the bulk active ingredient cost 
component of material costs under Section 1.5 herein is less than HMRI's 
actual cost per U.S. GAAP net of any intercompany profits.

   11.5  Breach or Misrepresentation.  In the event of any material breach of 
this Agreement or any material misrepresentation of any representation or 
warranty contained herein by either party, the other party shall give the 
breaching party written notice thereof.  The breaching party shall have thirty 
(30) days after receipt of written notice to cure said breach.  If cure is not 
effected within the thirty (30) day period, the nonbreaching party shall have 
the right to terminate this Agreement.

12.  NOTICES

    Except for COPLEY's Product orders which shall be sent to the address 
specified in Section 9 hereof, all notices which COPLEY gives HMRI shall be 
sent prepaid, either by first class mail, return receipt requested, express 
courier, telecopy, cable, or telex, addressed to HMRI as follows, unless 
otherwise notified in writing:

Hoechst Marion Roussel, Inc.
10236 Marion Park Drive
P.O. Box 9627
Kansas City, MO 64134-0627
Attn:  North America General Counsel
Telecopy:  (816) 966-3805

All notices which HMRI gives to COPLEY shall be sent in the same manner, 
addressed to COPLEY as follows, unless otherwise notified in writing:

Copley Pharmaceutical, Inc.
Canton Commerce Center
25 John Road
Canton, MA  02021
Attn:  President or Chief Financial Officer
Telecopy:  (617) 575-1856

    Any notice sent by mail shall be deemed given seventy-two (72) hours after 
the deposits thereof.  Any notice sent by express courier, telecopy, cable or 
telex shall be deemed given when actually received.


<PAGE 11>

13.  ASSIGNABILITY

    Neither party shall be entitled to assign its rights and obligations under 
this Agreement without the other party's prior written consent; provided, 
however, that (i) HMRI may assign its rights and obligations under this 
Agreement to any member of the Hoechst group companies engaged in the 
manufacture or sale of pharmaceutical products without the prior written
consent of COPLEY or its assignee, and (ii) in the event of a sale of all or 
substantially all of the assets of COPLEY, COPLEY may assign its rights under 
this Agreement to the purchaser of such assets, provided such purchaser 
expressly assumes all of COPLEY's obligations under this Agreement, without 
the prior written consent of HMRI or its assignee.

14.  DISPUTE RESOLUTION

    Disputes between the parties will be settled by arbitration conducted 
under rules established by the American Arbitration Association.  The venue of 
such arbitration proceeding shall be in the state in which the party 
complained against resides.

15.  SEVERING CLAUSE

    If any portion of this Agreement is held invalid by a court of competent 
jurisdiction, such portion shall be deemed to be of no force and effect and 
the Agreement shall be construed as if such portion had not been included 
herein.

16.  ENTIRE AGREEMENT

    This Agreement contains the sole and entire understanding of the parties 
related to its subject matter and supersedes all prior or contemporaneous oral 
or written agreements concerning the subject matter.

17.  MODIFICATION

    This Agreement cannot be changed orally and no modification of this 
Agreement shall be recognized nor have any effect, unless the writing in which 
it is set forth is signed by HMRI and COPLEY, nor shall any waiver of any of 
the provisions of this Agreement be effective unless in writing and signed by
the party to be charged therewith.

18.  WAIVER

    The failure of either party to enforce, at any time, or for any period of 
time, the provisions hereof or the failure of either party to exercise any 
option herein shall not be construed as a waiver of such provision or option
and shall in no way affect that party's right to enforce such provisions or 
exercise such option.  No waiver of any provision hereof shall be deemed a 
waiver of any succeeding breach of the same or any other provisions of this
Agreement.


<PAGE 12>

19.  APPLICABLE LAW

    This Agreement shall be deemed to have been entered into within and shall 
be governed, construed and enforced in accordance with the laws of the State 
of Delaware, regardless of the choice of law principles of that or any other 
jurisdiction.

          IN WITNESS WHEREOF, the parties have caused this Agreement to be 
executed by the respective duly authorized officers on the dates and at the 
place indicated below:

COPLEY PHARMACEUTICAL, INC.                HOECHST MARION ROUSSEL, INC.


By:  /s/  Gene M. Bauer                    By:  /s/ Edward H. Stratemeier      
     --------------------------------           ----------------------------

Title: Executive Vice President and       Title: Vice President and
         Secretary                                 General Counsel
       ------------------------------           ---------------------------- 











<PAGE 13>

                                 SCHEDULE 1.1


                              MINIMUM QUANTITY


Strength                    Package Size               Minimum Quantity

1.5 mg                        100 BTLS                      30,000

3.0 mg                        100 BTLS                      30,000
	                        500 BTLS                       6,000
                             1000 BTLS                       3,000







<PAGE 14>


                               EXHIBIT A

                                   to

                          Amended and Restated
                     Micronized Glyburide Agreement
                                Between
                       Hoechst Marion Roussel, Inc.
                                 and
                       Copley Pharmaceutical, Inc.




                          1997 COST OF GOODS


During 1997, COPLEY's cost of goods for the Products from HMRI FOB 
Bridgewater, New Jersey (or such other U.S. location to which HMRI may move 
production of the Product) shall be based upon a bulk micronized glyburide 
delivered cost to HMRI of [*] per kilo and shall be as follows:


                               1.50 mg
                              --------- 
                                100's
                                -----
                                $[*]

                             
                               3.00 mg
                              ---------
             100's              500's              1000's
             -----              -----              ------ 
             $[*]               $[*]                $[*]                 




[*] Confidential portion has been omitted pursuant to a request for 
confidential treatment and has been filed separately with the Commission.




<PAGE 15>

                               EXHIBIT B

                                   to

                          Amended and Restated
                     Micronized Glyburide Agreement
                                Between
                       Hoechst Marion Roussel, Inc.
                                 and
                       Copley Pharmaceutical, Inc.




              CALCULATION OF HMRI REVENUE SHARE (Section 1.7)



COPLEY Gross Sales                                          $XXX

Less Actual:

					Chargebacks       $XXX
					Rebates           $XXX
					Price Adjustments $XXX
					Cash Discounts    $XXX

Net Sales                                            $XXX

Less Cost of Goods*                                         $XXX
                                                            ----

Net Profit Margin                                           $XXX

HMRI Net Profit Margin Share Percentage                     x [*]
                                                            ----

HMRI Net Profit Margin Share                                $XXX
                                                            ====



* Cost of Goods calculated on a fully allocated basis according to generally 
accepted accounting principles (as set forth in Section 1.5).



[*] Confidential portion has been omitted pursuant to a request for 
confidential treatment and has been filed separately with the Commission.