----

----

|   |   |   |
|--------|--------|--------|

|   |   |   |
|--------|--------|--------|

| x | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
|---|--------------------------------------------------------------------------------------|

| o | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
|---|------------------------------------------------------------------------------------------|

|   |   |   |
|--------|--------|--------|

| Delaware                                 | 56-1581761          |
|------------------------------------------|---------------------|
| (State or other jurisdiction of          | (I.R.S. Employer    |
| incorporation or organization)           | identification no.) |
|                                     |                |
| 111 Pencader Drive                       |                |
| Newark, Delaware                         | 19702               |
| (Address of principal executive offices) | (Zip Code)          |

|   |   |   |
|--------|--------|--------|

|   |                                     | Title of Each Class |   |                        |   | Name of Each Exchange on Which Registered |   |
|--------|------------------------------------------|---------------------|--------|-----------------------------|--------|-------------------------------------------|--------|
|   | Common Stock, $0.01 par  value |                |   | The NASDAQ Stock Market LLC |   |

|   |   |   |
|--------|--------|--------|

|                      |                |                                          |                        |
|---------------------------|---------------------|-----------------------------------------------|-----------------------------|
| Large Accelerated Filer o | Accelerated Filer o | Non-Accelerated Filer o                       | Smaller Reporting Company x |
|                      |                | (Do not check if a smaller reporting company) |                        |

----

----

----

----

|     |                                                                                           |   |
|----------|------------------------------------------------------------------------------------------------|--------|
| PART III |                                                                                           |   |
|     |                                                                                           |   |
| Item 10. | Directors, Executive Officers and Corporate Governance                                         | 4      |
|     |                                                                                           |   |
| Item 11. | Executive Compensation                                                                         | 10     |
|     |                                                                                           |   |
| Item 12. | Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters | 15     |
|     |                                                                                           |   |
| Item 13. | Certain Relationships and Related Transactions, and Director Independence                      | 16     |
|     |                                                                                           |   |
| Item 14. | Principal Accounting Fees and Services                                                         | 16     |
|     |                                                                                           |   |
| PART IV  |                                                                                           |   |
|     |                                                                                           |   |
| Item 15. | Exhibits and Financial Statement Schedules                                                     | 17     |

----

|                                                                  |   |   |   |          |   |
|-----------------------------------------------------------------------|--------|--------|--------|---------------|--------|
| Name and Principal Occupation                                         |   | Age    |   | DirectorSince |   |
|                                                                  |   |   |   |          |   |
| Steven Becker                                                         |   | 46     |   | 2008          |   |
| Chairman of the Board of Directors                                    |   |   |   |          |   |
| Founder and Managing Partner - Becker Drapkin Management              |   |   |   |          |   |
|                                                                  |   |   |   |          |   |
| Thomas A. Bologna                                                     |   | 64     |   | 2010          |   |
| CEO – Response Genetics, Inc.                                   |   |   |   |          |   |
|                                                                  |   |   |   |          |   |
| Richard van den Broek (1)                                             |   | 47     |   | 2008          |   |
| Managing Partner – HSMR Advisors, LLC                           |   |   |   |          |   |
|                                                                  |   |   |   |          |   |
| C. Geoffrey Davis (1)                                                 |   | 62     |   | 2007          |   |
| President and CEO - Angelica Therapeutics, Inc.                       |   |   |   |          |   |
|                                                                  |   |   |   |          |   |
| Francis M. DiNuzzo                                                    |   | 57     |   | 2008          |   |
| President and CEO of the Company                                      |   |   |   |          |   |
|                                                                  |   |   |   |          |   |
| Stephen L. Waechter (1)                                               |   | 63     |   | 2002          |   |
| Chief Financial Officer – Aeronautical Radio, Inc               |   |   |   |          |   |
|                                                                  |   |   |   |          |   |
| David M. Wurzer                                                       |   | 54     |   | 2010          |   |
| Senior Managing Director, Investments – Connecticut Innovations |   |   |   |          |   |
|                                                                  |   |   |   |          |   |
| Wayne P. Yetter (1)                                                   |   | 67     |   | 2010          |   |
| Retired Pharmaceutical and Healthcare Executive                       |   |   |   |          |   |

|   |
|--------|

----

----

|               |   |   |   |                                                                |   |     |   |
|--------------------|--------|--------|--------|---------------------------------------------------------------------|--------|----------|--------|
| Name               |   |   | Age    |                                                                |   | Position |   |
|               |   |   |   |                                                                |
| Francis M. DiNuzzo |   | 57     |   | President and Chief Executive Officer                               |
| Kevin J. Bratton   |   | 64     |   | VP – Finance, Chief Financial Officer and Corporate Secretary |

----

|                                                                              |   |   |   |   |
|-----------------------------------------------------------------------------------|--------|--------|--------|--------|
| Chairman of the Board                                                             |   | $      | 20,000 |   |
| Lead Outside Director (if any)                                     |   | $      | 10,000 |   |
| Audit Committee Chair                                                             |   | $      | 10,000 |   |
| Compensation, Strategy and Nominating & Corporate Governance Committee Chairs |   | $      | 6,000  |   |
| Committee Membership (non-Chair)                                                  |   | $      | 3,000  |   |

----

| Name    |   | Fees Earned orPaid in Cash |   |   | Share Awards (1) |   |   | Option Awards (1) |   |   | All OtherCompensation |   |   | Total  |   |
|------------------------|--------|----------------------------|--------|--------|------------------|--------|--------|-------------------|--------|--------|-----------------------|--------|--------|--------|--------|
| Thomas A. Bologna      |   | $                          | 43,500 |   |             | $      | 4,959  |              |   | $      | 8,799                 |   |   |   | -      |   |   | $ | 57,258 |   |
| Steven R. Becker       |   | $                          | 51,500 |   |             | $      | 4,959  |              |   | $      | 8,063                 |   |   |   | -      |   |   | $ | 64,522 |   |
| C. Geoffrey Davis      |   | $                          | 39,000 |   |             | $      | 4,959  |              |   | $      | 8,063                 |   |   |   | -      |   |   | $ | 52,022 |   |
| Richard van den Broek  |   | $                          | 33,000 |   |             | $      | 4,959  |              |   | $      | 8,063                 |   |   |   | -      |   |   | $ | 46,022 |   |
| Stephen L. Waechter    |   | $                          | 43,000 |   |             | $      | 4,959  |              |   | $      | 8,063                 |   |   |   | -      |   |   | $ | 56,022 |   |
| David M. Wurzer        |   | $                          | 36,000 |   |             | $      | 4,959  |              |   | $      | 8,799                 |   |   |   | -      |   |   | $ | 49,758 |   |
| Wayne P. Yetter        |   | $                          | 39,000 |   |             | $      | 4,959  |              |   | $      | 9,994                 |   |   |   | -      |   |   | $ | 53,953 |   |

| (1) | The aggregate numbers of restricted shares and shares issuable upon the exercise of options to purchase shares for the directors outstanding as of December 31, 2012 are as follows: Mr. Bologna (5,000 shares; options to purchase 16,049 shares); Mr. Becker (23,230 shares, options to purchase 31,021 shares); Mr. Davis (24,096 shares; options to purchase 30,575 shares); Mr. van den Broek (23,230 shares; options to purchase 31,021 shares); Mr. Waechter (83,990 shares; options to purchase 91,000 shares); Mr. Wurzer (5,000 shares; options to purchase 16,049 shares); and Mr. Yetter (5,000 shares; options to purchase 15,869 shares). Options were granted with an exercise price of $1.85 per share. All grants vest in a series of two (2) successive equal annual installments beginning on the first anniversary of the grant date; and upon the optionee’s completion of each year of service as a Board member, over the two-year period measured from the option grant date. Awards were granted at a value of $1.59 per share, the fair market value on May 18, 2012, the date of the grant. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|                                                                                         |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                |   | Number of |
|----------------------------------------------------------------------------------------------|--------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|-----------|
|                                                                                         |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                |   | Meetings  |
| Committee and Members                                                                        |   | Functions of Committee                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              |   | in 2012   |
| AuditThomas A. BolognaStephen L. Waechter (1) (2)David M. Wurzer                             |   | ●     Selects the Company’s independent auditors●     Reviews the results and scope of the annual audit and the services provided by the Company’s independent auditors●     Reviews the recommendations of the Company’s independent auditors with respect to the accounting system and controls                                                                                                                                                                                    |   | 4         |
|                                                                                         |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                |   |      |
| CompensationSteven R. BeckerDavid M. WurzerWayne P. Yetter (1)                               |   | ●     Reviews and approves salaries for all corporate officers●     Reviews and approves all incentive and special compensation plans and programs●     Reviews and approves management succession planning●     Conducts special competitive studies●     Retains compensation consultants as necessary and appropriate●     Reviews and recommends to the Board compensation for non-employee directors |   | 4         |
|                                                                                         |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                |   |      |
| Nominating & Corporate GovernanceC. Geoffrey Davis (1)Stephen L. WaechterWayne P. Yetter |   | ●     Identifies individuals eligible to become members of the Board of Directors●     Select and recommend to the Board the director nominees for the Board for the next annual meeting of shareholders●     Oversee the evaluation of the Board                                                                                                                                                                                                                                                      |   | 3         |
|                                                                                         |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                |   |      |
| StrategySteven R. Becker (1)Thomas A. BolognaC. Geoffrey DavisRichard van den Broek          |   | ●     Provide oversight regarding the Company’s strategic direction●     Review, discuss and suggest revisions when necessary to management’s vision●     Understand, identify and discuss key issues, assumptions, risks and opportunities that relate to the development and implementation of appropriate strategies for the Company                                                                                                                                                    |   | 3         |

| (1) | Chairman |
|-----|----------|

----

| Name and Principal Position                               |   |   | Salary ($) |    | Bonus ($) |   | StockAwards($) (1) |   | Option Awards($) (2) |    | Non-EquityIncentive PlanCompensation($) |   | All OtherCompensation($) (3) |   |   | Total ($) |   |
|-----------------------------------------------------------|--------|--------|------------|---------|-----------|--------|--------------------|--------|----------------------|---------|-----------------------------------------|--------|------------------------------|--------|--------|-----------|--------|
|                                                      |   |   |       |    |      |   |               |   |                 |    |                                    |   |                         |   |   |      |   |
| Francis M. DiNuzzo                                        | 2012   |   |       | 350,000 |      |   | 78,750             |   |                 | 157,500 |                                    |   | 87,820                       |   |   | -         |   |   | 10,365 |   |   |   | 686,265 |   |
| President and Chief                                       | 2011   |   |       | 348,428 |      |   | 102,000            |   |                 | 10,328  |                                    |   | 101,555                      |   |   | -         |   |   | 12,195 |   |   |   | 574,506 |   |
| Executive Officer                                         |   |   |       |    |      |   |               |   |                 |    |                                    |   |                         |   |   |      |   |   |   |   |   |   |   |   |
|                                                      |   |   |       |    |      |   |               |   |                 |    |                                    |   |                         |   |   |      |   |   |   |   |   |   |   |   |
| Kevin J. Bratton                                          | 2012   |   |       | 252,144 |      |   | 52,549             |   |                 | 40,306  |                                    |   | 34,614                       |   |   | -         |   |   | 8,805 |   |   |   | 388,236 |   |
| Vice President and                                        | 2011   |   |       | 246,370 |      |   | 54,100             |   |                 | 19,455  |                                    |   | 30,455                       |   |   | -         |   |   | 8,623 |   |   |   | 359,003 |   |
| Chief Financial Officer                                   |   |   |       |    |      |   |               |   |                 |    |                                    |   |                         |   |   |      |   |   |   |   |   |   |   |   |
|                                                      |   |   |       |    |      |   |               |   |                 |    |                                    |   |                         |   |   |      |   |   |   |   |   |   |   |   |
| Klaus Lindpaintner                                        | 2012   |   |       | 210,357 |      |   | -                  |   |                 | 3,011   |                                    |   | 6,890                        |   |   | -         |   |   | 170,618 |   |   |   | 390,876 |   |
| Vice President and                                        | 2011   |   |       | 271,500 |      |   | 59,700             |   |                 | 21,307  |                                    |   | 31,202                       |   |   | -         |   |   | 9,503 |   |   |   | 393,212 |   |
| Chief Scientific Officer     (4) |   |   |       |    |      |   |               |   |                 |    |                                    |   |                         |   |   |      |   |   |   |   |   |   |   |   |

| (1) | The amounts shown for stock awards are equal to the grant date fair value of the awards, calculated in accordance with Financial Accounting Standards Board Accounting Standards Codification (“ASC”) Topic 718. The assumptions used in determining the amounts in this column are set forth in note 8 to our consolidated financial statements in our Annual Report on Form 10-K for the fiscal year ended December 31, 2012 filed with the Securities and Exchange Commission. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (2) | These amounts are based upon the grant date fair value of the option awards calculated in accordance with ASC Topic 718. The assumptions used in determining the amounts in the column are set forth in note 8 to our consolidated financial statements in our Annual Report on Form 10-K for the fiscal year ended December 31, 2012 filed with the Securities and Exchange Commission. The value of the share options granted in 2012 reflects a per option value of $0.74 for Mr. Bratton for February 28, 2012 grants, arrived at through a Black-Scholes analysis. The assumptions used in this analysis were expected life of 6.17; volatility of 48.7%; and risk free interest rates of 1.08%. There was no dividend yield involved in this analysis. |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (3) | All other compensation includes Company matching contributions to 401(k) accounts. |
|-----|------------------------------------------------------------------------------------|

| (4) | Dr. Lindpaintner’s employment terminated as of September 25, 2012. Included in All Other Compensation are payments of $163,863 for severance and accrued vacation time. |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|               |   |                                                 |    |         |          |   |    |                      |   |                 |   |                                                         |       |   |                                                               |   |   |   |   |   |   |
|--------------------|--------|------------------------------------------------------|---------|--------------|---------------|--------|---------|---------------------------|--------|----------------------|--------|--------------------------------------------------------------|------------|--------|--------------------------------------------------------------------|--------|--------|--------|--------|--------|--------|
|               |   |  Option Awards                                  |    | Stock Awards |          |
|               |   |  Number of Shares UnderlyingUnexercised Options |    |         |          |   |    |                      |   |                 |   |                                                         |       |
|   Name        |   |  Exercisable                                    |    |         | Unexercisable |   |    |  OptionExercisePrice |   | OptionExpirationDate |   |  Number ofof Shares orUnits or StockThat HaveNot Vested |       |   |  Market Valueof Shares orUnits ofStock thatHave NotVested (1) |   |
| Francis M. DiNuzzo |   |                                                 | 60,000  |         |          |   | --      |                      |   | $                    | 4.60   |                                                         | 2/25/2018  |   |                                                               | --     |   |   |   | --     |   |
|               |   |                                                 | 25,000  |         |          |   | --      |                      |   | $                    | 3.70   |                                                         | 6/11/2018  |   |                                                               | --     |   |   |   | --     |   |
|               |   |                                                 | 250,000 |         |          |   | --      |                      |   | $                    | 1.50   |                                                         | 10/13/2018 |   |                                                               | --     |   |   |   | --     |   |
|               |   |                                                 | 34,000  |         |          |   | 34,000  |                      |   | $                    | 1.66   |                                                         | 2/17/2020  |   |                                                               | --     |   |   |   | --     |   |
|               |   |                                                 | --      |         |          |   | 125,000 |                      |   | $                    | 2.19   |                                                         | 3/1/2021   |   |                                                               | --     |   |   |   | --     |   |
| Kevin J. Bratton   |   |                                                 | 56,250  |         |          |   | 18,750  |                      |   | $                    | 1.50   |                                                         | 6/1/2019   |   |                                                               | --     |   |   |   | --     |   |
|               |   |                                                 | 12,500  |         |          |   | 12,500  |                      |   | $                    | 1.69   |                                                         | 6/1/2020   |   |                                                               | --     |   |   |   | --     |   |
|               |   |                                                 | 12,500  |         |          |   | 37,500  |                      |   | $                    | 2.19   |                                                         | 3/1/2021   |   |                                                               | --     |   |   |   | --     |   |
|               |   |                                                 | --      |         |          |   | 15,000  |                      |   | $                    | 2.10   |                                                         | 2/28/2022  |   |                                                               | 6,250  |   |   | $      | 6,688  |   |
|               |   |                                                 | --      |         |          |   | --      |                      |   |                 | --     |                                                         | --         |   |                                                               | 12,500 |   |   | $      | 13,375 |   |
|               |   |                                                 |    |         |          |   |    |                      |   |                 |   |                                                         |       |   |                                                               |   |   |   |   |   |   |

|   |
|--------|

| (1) | Value is calculated by multiplying the number of shares subject to vesting by $1.07, the closing price of the common shares on the NASDAQ Global Market on December 31, 2012. |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|                                                  |   | Number of         |      |   |              |   |   | Number of securities    |   |
|-------------------------------------------------------|--------|-------------------|-----------|--------|-------------------|--------|--------|-------------------------|--------|
|                                                  |   | securities to be  |      |   |              |   |   | remaining available     |   |
|                                                  |   | issued upon       |      |   | Weighted-average  |   |   | for issuance under      |   |
|                                                  |   | exercise of       |      |   | exercise price of |   |   | equity compensation     |   |
|                                                  |   | outstanding       |      |   | outstanding       |   |   | plans (excluding        |   |
|                                                  |   | options, warrants |      |   | options, warrants |   |   | securities reflected in |   |
|                                                  |   | and rights        |      |   | and rights        |   |   | column (a))             |   |
| Plan Category                                         |   | (a)               |      |   | (b)               |   |   | (c)                     |   |
| Equity compensation plan approved by security holders |   |              | 2,533,793 |   |              | $      | 2.10   |                    |   |   | 2,710,538 |   |
|                                                  |   |              |      |   |              |   |   |                    |   |   |   |   |
| Equity compensation not approved by security holders  |   |              | 81,250    |   |              | $      | 1.49   |                    |   |   | - |   |
|                                                  |   |              |      |   |              |   |   |                    |   |   |   |   |
| Total                                                 |   |              | 2,615,043 |   |              | $      | 2.08   |                    |   |   | 2,710,538 |   |

|   | ● | The majority of stock-based awards are approved annually by the Compensation Committee on a pre-scheduled date, in connection with the final determinations regarding compensation for the preceding year. |
|--------|---------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|   | ● | Stock-based awards other than annual awards may be granted to address, among other things, the recruiting or hiring of new employees and promotions. |
|--------|---------|------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | ● | The Compensation Committee has established that stock options are granted only on the date the Compensation Committee approves the grant and with an exercise price equal to the closing price of the common stock on the NASDAQ Global Market on the date of grant or, in certain cases, above such closing price. |
|--------|---------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|   | Name                                           |   | Approximate PaymentAmount ($)                    |   |
|--------|------------------------------------------------|--------|--------------------------------------------------|--------|
|   |                                           |   |                                             |   |
|   | Francis M. DiNuzzo                             |   |       $428,750 (1) |   |
|   |                                           |   |                                             |   |
|   | Kevin J. Bratton      |   | $316,976                                         |   |

|   |                                                                                                          |
|--------|---------------------------------------------------------------------------------------------------------------|
| (1)    | Any payments to Mr. DiNuzzo are contingent on his entering into a general release agreement with the Company. |

----

| Name and Address of Beneficial Owner              |   |   | Amount and Nature ofBeneficial Ownership |  (1) |   | Options ExercisableWithin 60 Days AfterRecord Date |    |   | Total BeneficialOwnership |   |      | Percent ofClass |   |
|---------------------------------------------------|--------|--------|------------------------------------------|-----------|--------|----------------------------------------------------|---------|--------|---------------------------|--------|-----------|-----------------|--------|
|                                              |   |   |                                     |      |   |                                               |    |   |                      |   |      |            |
| Steven R. Becker                                  |   |   | 3,460,693                                | (2)       |   |                                               | 51,021  |   |                      |   | 3,511,714 |            |   |   | 16.6 | % |
| Francis M. DiNuzzo                                |   |   | 88,188                                   |      |   |                                               | 448,500 | (7)    |                      |   | 536,688   |            |   |   | 2.5 | % |
| Richard van den Broek                             |   |   | 235,630                                  | (3)       |   |                                               | 51,021  |   |                      |   | 286,651   |            |   |   | 1.4 | % |
| Stephen L. Waechter                               |   |   | 86,490                                   |      |   |                                               | 83,000  |   |                      |   | 169,490   |            |   |   |   | *  |
| Kevin J. Bratton                                  |   |   | 56,825                                   |      |   |                                               | 122,500 | (8)    |                      |   | 179,325   |            |   |   |   | *  |
| C. Geoffrey Davis                                 |   |   | 26,596                                   |      |   |                                               | 50,575  |   |                      |   | 77,171    |            |   |   |   | *  |
| David M. Wurzer                                   |   |   | 12,500                                   |      |   |                                               | 41,574  |   |                      |   | 54,074    |            |   |   |   | *  |
| Thomas Bologna                                    |   |   | 10,000                                   |      |   |                                               | 41,574  |   |                      |   | 51,574    |            |   |   |   | *  |
| Wayne P. Yetter                                   |   |   | 7,500                                    |      |   |                                               | 41,304  |   |                      |   | 48,804    |            |   |   |   | *  |
| All officers and directors as a group (9 persons) |   |   | 3,984,422                                |      |   |                                               | 931,069 |   |                      |   | 4,915,491 |            |   |   | 22.3 | % |
|                                              |   |   |                                     |      |   |                                               |    |   |                      |   |      |            |   |   |   |   |
| Becker Drapkin Management, LLC                    |   |   |                                     |      |   |                                               |    |   |                      |   |      |            |   |   |   |   |
| 300 Crescent Court, Suite 111                     |   |   |                                     |      |   |                                               |    |   |                      |   |      |            |   |   |   |   |
| Dallas, Texas 75201                               |   |   | 3,295,304                                | (4)       |   |                                               |    |   |                      |   | 3,295,304 |            |   |   | 15.6 | % |
|                                              |   |   |                                     |      |   |                                               |    |   |                      |   |      |            |   |   |   |   |
| T. Rowe Price Associates, Inc.                    |   |   |                                     |      |   |                                               |    |   |                      |   |      |            |   |   |   |   |
| 100 E. Pratt Street                               |   |   |                                     |      |   |                                               |    |   |                      |   |      |            |   |   |   |   |
| Baltimore, Maryland 21202                         |   |   | 1,657,000                                | (5)       |   |                                               |    |   |                      |   | 1,657,000 |            |   |   | 7.9 | % |
|                                              |   |   |                                     |      |   |                                               |    |   |                      |   |      |            |   |   |   |   |
| Stephens Investment Management, LLC               |   |   |                                     |      |   |                                               |    |   |                      |   |      |            |   |   |   |   |
| One Ferry Building, Suite 255                     |   |   |                                     |      |   |                                               |    |   |                      |   |      |            |   |   |   |   |
| San Francisco, California 94111                   |   |   | 490,271                                  | (6)       |   |                                               |    |   |                      |   | 490,271   |            |   |   | 2.3 | % |

|                       |   |
|----------------------------|--------|
| * Represents less than 1%. |   |

| (1) | Unless otherwise indicated, each of the stockholders has sole voting and investment power with respect to the securities shown to be owned by such stockholder. The inclusion herein of securities listed as beneficially owned does not constitute an admission of beneficial ownership.                                                                                                                                                                                                                                                                                                                                                                            |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| (2) | Includes 3,295,304 shares held by Becker Drapkin Management, of which Mr. Becker is a co-managing partner.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
| (3) | Includes 200,000 shares held by HSMR Advisors, LLC, of which Mr. van den Broek is the managing partner.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              |
| (4) | The Company has relied solely on Form 4 dated July 3, 2012 for this information.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     |
| (5) | The Company has relied solely on Schedule 13G dated February 14, 2013 for this information.  These securities are owned by various individual and institutional investors, including T. Rowe Price Small-Cap Value Fund, Inc., which T. Rowe Price Associates, Inc. (Price Associates) serves as investment adviser with the power to direct investments and/or the sole power to vote the securities. For purposes of the reporting requirements of the Exchange Act, Price Associates is deemed to be a beneficial owner of such securities; however, Price Associates expressly disclaims that it is, in fact, the beneficial owner of such securities. |
| (6) | The Company has relied solely on Schedule 13G dated February 14, 2013 for this information.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |
| (7) | Does not include 75,000 performance based restricted stock units                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     |
| (8) | Does not include 50,000 performance based restricted stock units                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     |

----

----

| Exhibit Number |   | Description                                                                                                                                                                                                                                                                                          |   | Reference |
|----------------|--------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|-----------|
| 2.1            |   | Agreement and Plan of Merger among the Company, AZUR Acquisition Corp. and AZUR Environmental dated May 4, 2001                                                                                                                                                                                      |   | (1)       |
|           |   |                                                                                                                                                                                                                                                                                                 |   |      |
| 2.2            |   | Asset Purchase Agreement, dated as of November 10, 2011, by and among Strategic Diagnostics Inc., a Delaware corporation, Modern Water Inc., a Delaware corporation, and MW Monitoring IP Limited, a limited liability company incorporated under the laws of England and Wales.@                    |   | (24)      |
|           |   |                                                                                                                                                                                                                                                                                                 |   |      |
| 2.3            |   | Amendment No. 1 to Asset Purchase Agreement, dated as of December 8, 2011, by and among Strategic Diagnostics Inc., a Delaware corporation, Modern Water Inc., a Delaware corporation, and MW Monitoring IP Limited, a limited liability company incorporated under the laws of England and Wales.@. |   | (25)      |
|           |   |                                                                                                                                                                                                                                                                                                 |   |      |
| 2.4            |   | Asset Purchase Agreement, dated as of September 28, 2012 by and between Strategic Diagnostics Inc., a Delaware corporation and Romer Labs Technology, Inc., a Delaware corporation.                                                                                                                  |   | (26)      |
|           |   |                                                                                                                                                                                                                                                                                                 |   |      |
| 2.5            |   | Asset Purchase Agreement, dated as of April 5, 2013 by and between Strategic Diagnostics Inc., a Delaware corporate and SDIX, LLC, a Delaware limited liability company, and OriGene Technologies, Inc., a Delaware corporation.                                                                     |   | (28)      |
|           |   |                                                                                                                                                                                                                                                                                                 |   |      |
| 3.1            |   | Fourth Amended and Restated Certificate of Incorporation of the Company                                                                                                                                                                                                                              |   | (2)       |
|           |   |                                                                                                                                                                                                                                                                                                 |   |      |
| 3.2            |   | Amended and Restated Bylaws of the Company                                                                                                                                                                                                                                                           |   | (2)       |
|           |   |                                                                                                                                                                                                                                                                                                 |   |      |
| 4.1            |   | Forms of Warrants to Purchase Common Stock of the Company                                                                                                                                                                                                                                            |   | (2)       |
|           |   |                                                                                                                                                                                                                                                                                                 |   |      |
| 10.1           |   | Stock Purchase Agreement among the Company and its outside directors and certain of their affiliates dated August 16, 2002                                                                                                                                                                           |   | (12)      |
|           |   |                                                                                                                                                                                                                                                                                                 |   |      |
| 10.2           |   | Demand Registration Rights Agreement among the Company and its outside directors and                                                                                                                                                                                                                 |   | (12)      |
|           |   | certain of their affiliates dated August 16, 2002                                                                                                                                                                                                                                                    |   |      |
|           |   |                                                                                                                                                                                                                                                                                                 |   |      |
| 10.3           |   | EnSys Environmental Products, Inc. 1993 Stock Incentive Plan*                                                                                                                                                                                                                                        |   | (3)       |
|           |   |                                                                                                                                                                                                                                                                                                 |   |      |
| 10.4           |   | Amended and Restated EnSys Environmental Products, Inc. 1995 Stock Incentive Plan*                                                                                                                                                                                                                   |   | (4)       |
|           |   |                                                                                                                                                                                                                                                                                                 |   |      |
| 10.5           |   | EnSys Environmental Products, Inc. 401(k) Plan Adoption Agreement                                                                                                                                                                                                                                    |   | (3)       |
|           |   |                                                                                                                                                                                                                                                                                                 |   |      |
| 10.11          |   | Agreement and Plan of Merger by and between EnSys and Strategic Diagnostics Inc. dated as of October 11, 1996                                                                                                                                                                                        |   | (2)       |
|           |   |                                                                                                                                                                                                                                                                                                 |   |      |
| 10.18          |   | Industrial Lease dated October 26, 1993, by and between Tober & Agnew Properties, Inc. and Strategic Diagnostics Inc.                                                                                                                                                                            |   |      |
|           |   |                                                                                                                                                                                                                                                                                                 |   |      |
| 10.21          |   | Lease agreement dated October 29, 1997 by and between Pencader Courtyard, L.P. and Strategic Diagnostics Inc.                                                                                                                                                                                        |   | (7)       |
|           |   |                                                                                                                                                                                                                                                                                                 |   |      |
| 10.22          |   | 1998 Employee Stock Purchase Plan                                                                                                                                                                                                                                                                    |   | (11)      |
|           |   |                                                                                                                                                                                                                                                                                                 |   |      |
| 10.23          |   | 2000 Stock Incentive Plan*                                                                                                                                                                                                                                                                           |   | (17)      |
|           |   |                                                                                                                                                                                                                                                                                                 |   |      |
| 10.33          |   | Employment Agreement dated January 1, 1997 by and between James W. Stave and the Company*                                                                                                                                                                                                            |   | (14)      |
|           |   |                                                                                                                                                                                                                                                                                                 |   |      |
| 10.34          |   | Amended and Restated Distribution Agreement, dated as of August 31, 2009, by and between the Registrant and the DuPont Qualicon division of E.I. du Pont de Nemours and Company+                                                                                                                     |   | (15)      |

----

| 10.35  |   | Strategic Diagnostics Inc. Change of Control Severance Agreement*                                                                                      |   | (16)   |
|--------|--------|--------------------------------------------------------------------------------------------------------------------------------------------------------|--------|--------|
|   |   |                                                                                                                                                   |   |   |
| 10.36  |   | Agreement, dated as of March 12, 2008, by and among the Company and Steven R. Becker, BC Advisors, LLC, SRB Management, L.P. and Richard van den Broek |   | (18)   |
|   |   |                                                                                                                                                   |   |   |
| 10.38  |   | Employment Agreement, dated as of October 13, 2008, between Strategic Diagnostics Inc. and Francis M. DiNuzzo*                                         |   | (20)   |
|   |   |                                                                                                                                                   |   |   |
| 10.41  |   | Separation Agreement, dated as of September 25, 2012, between Strategic Diagnostics Inc. and Klaus Lindpaintner.*                                      |   | (27)   |
|   |   |                                                                                                                                                   |   |   |
| 10.42  |   | Form of Nonqualified Stock Option Agreement                                                                                                            |   | (23)   |
|   |   |                                                                                                                                                   |   |   |
| 10.43  |   | Form of Restricted Stock Grant Agreement                                                                                                               |   | (23)   |
|   |   |                                                                                                                                                   |   |   |
| 21.1   |   | Subsidiaries of the Company                                                                                                                            |   | (29)   |
|   |   |                                                                                                                                                   |   |   |
| 23.1   |   | Consent of KPMG LLP, Independent Registered Public Accounting Firm                                                                                     |   | (29)   |
|   |   |                                                                                                                                                   |   |   |
| 31.1   |   | Certifications of the Chief Executive Officer of Strategic Diagnostics Inc. required by Rule13a-14(a) under the Securities Exchange Act of 1934        |   |   |
|   |   |                                                                                                                                                   |   |   |
| 31.2   |   | Certifications of the Chief Financial Officer of Strategic Diagnostics Inc. required by Rule13a-14(a) under the Securities Exchange Act of 1934        |   |   |
|   |   |                                                                                                                                                   |   |   |
| 32.1   |   | Certification of Francis M. DiNuzzo pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of Sarbanes-Oxley Act of 2002               |   |   |
|   |   |                                                                                                                                                   |   |   |
| 32.2   |   | Certification of Kevin J. Bratton pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of Sarbanes-Oxley Act of 2002                 |   |   |

----

| (1)  | Incorporated by reference to the designated exhibit of the Company’s 10-Q for the fiscal quarter ended September 30, 2001.                                                     |
|------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| (2)  | Incorporated by reference to the designated exhibit of the EnSys Registration Statement on Form S-4 (No. 333-17505) filed on December 9, 1996.                                       |
| (3)  | Incorporated by reference to the designated exhibit of the EnSys Registration Statement on Form S-1 (No. 33-68440) filed on September 3, 1993.                                       |
| (4)  | Incorporated by reference to Appendix F to the Joint Proxy Statement/Prospectus contained in the EnSys Registration Statement on Form S-4 (No. 333-17505) filed on December 9, 1996. |
| (5)  | Incorporated by reference to the designated exhibit of the EnSys Form 10-K for the fiscal year ended December 31, 1994.                                                              |
| (6)  | Incorporated by reference to the designated exhibit of the EnSys Form 10-Q for the fiscal quarter ended March 31, 1996.                                                              |
| (7)  | Incorporated by reference to the designated exhibit of the Company’s Form 10-K for the fiscal year ended December 31, 1996.                                                    |
| (8)  | Incorporated by reference to the designated exhibit of the Company’s Form 10-K for the fiscal year ended December 31, 1997.                                                    |
| (9)  | Incorporated by reference to the identically numbered exhibit contained in the Company’s Form 8-K filed on May 26, 1999.                                                       |
| (10) | Incorporated by reference to the designated exhibit of the Company’s 10-Q for the fiscal quarter ended June 30, 2000.                                                          |
| (11) | Incorporated by reference to the designated exhibit of the Company’s Registration Statement on Form S-8 (No. 333- 68107) filed on November 30, 1998.                           |
| (12) | Incorporated by reference to the designated exhibit of the Company’s 10-Q for the fiscal quarter ended September 30, 2002.                                                     |
| (13) | Incorporated by reference to the designated exhibit of the Company’s Form 10-Q for the fiscal quarter ended September 30, 2003.                                                |
| (14) | Incorporated by reference to the designated exhibit of the Company’s Form 10-K for the fiscal year ended December 31, 2004.                                                    |
| (15) | Incorporated by reference to the designated exhibit of the Company’s Form 10-Q for the fiscal quarter ended September 30, 2009, as amended.                                    |
| (16) | Incorporated by reference to the designated exhibit of the Company’s Form 10-Q for the fiscal quarter ended September 30, 2005.                                                |
| (17) | Incorporated by reference to Appendix A of the Company’s Definitive Proxy Statement filed with the Securities and Exchange Commission on March 24, 2004.                       |
| (18) | Incorporated by reference to Exhibit 99.1 of the Company’s Form 8-K filed March 18, 2008.                                                                                      |
| (19) | Incorporated by reference to Exhibit 99.1 of the Company’s Form 8-K filed June 6, 2008.                                                                                        |
| (20) | Incorporated by reference to Exhibit 99.1 of the Company’s Form 8-K filed October 16, 2008.                                                                                    |
| (21) | Incorporated by reference to Exhibit 99.1 of the Company’s Form 8-K filed December 9, 2008.                                                                                    |

----

| (22) | Incorporated by reference to Exhibit 10.1 of the Company’s Form 10-Q for the fiscal quarter ended March 31, 2009.                                                                                                                                             |
|------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| (23) | Incorporated by reference to the designated exhibit of the Company’s Form 10-k for the fiscal year ended December 31, 2009.                                                                                                                                   |
| (24) | Incorporated by reference to Exhibit 99.1 of the Company’s Form 8-K filed November 16, 2011.                                                                                                                                                                  |
| (25) | Incorporated by reference to Exhibit 99.1 of the Company’s Form 8-K filed December 13, 2011.                                                                                                                                                                  |
| (26) | Incorporated by reference to Exhibit 2.1 of the Company’s Form 8-K filed October 22, 2012.                                                                                                                                                                    |
| (27) | Incorporated by reference to Exhibit 99.1 of the Company’s Form 8-K filed October 1, 2012.                                                                                                                                                                    |
| (28) | Incorporated by reference to Exhibit 1.01 of the Company’s Form 8-K filed April 10, 2013.                                                                                                                                                                     |
| (29) | Previously filed.                                                                                                                                                                                                                                                   |
| *    | Management contract or compensatory plan.                                                                                                                                                                                                                           |
| +    | Confidential treatment has been granted as to certain portions of this exhibit pursuant to Rule 24b-2 under the Securities Exchange Act of 1934, as amended.                                                                                                        |
| @    | Schedules and similar attachments have been omitted pursuant to Item 601(b)(2) of Regulation S-K. The Company undertakes to furnish supplementally copies of any of the omitted schedules and exhibits upon request by the U.S. Securities and Exchange Commission. |

----

|   |           |                                            |
|--------|----------------|-------------------------------------------------|
|   |           | STRATEGIC DIAGNOSTICS INC.                      |
|   |           |                                            |
| Date:  | April 30, 2013 | /s/ Francis M. DiNuzzo                          |
|   |           | Francis M. DiNuzzo                              |
|   |           | President, Chief Executive Officer and Director |

|   |           |                                                                                                   |   |
|--------|----------------|--------------------------------------------------------------------------------------------------------|--------|
| Date:  | April 30, 2013 | /s/ Steven Becker                                                                                      |   |
|   |           | Steven Becker                                                                                          |   |
|   |           | Chairman of the Board of Directors                                                                     |   |
|   |           |                                                                                                   |   |
| Date:  | April 30, 2013 | /s/ Francis M. DiNuzzo                                                                                 |   |
|   |           | Francis M. DiNuzzo                                                                                     |   |
|   |           | President, Chief Executive Officer and Director(Principal Executive Officer)                           |   |
|   |           |                                                                                                   |   |
| Date:  | April 30, 2013 | /s/ Kevin J. Bratton                                                                                   |   |
|   |           | Kevin J. Bratton                                                                                       |   |
|   |           | Vice President – Finance and Chief Financial Officer(Principal Financial and Accounting Officer) |   |
|   |           |                                                                                                   |   |
| Date:  | April 30, 2013 | /s/ Thomas A. Bologna                                                                                  |   |
|   |           | Thomas A. Bologna                                                                                      |   |
|   |           | Director                                                                                               |   |
|   |           |                                                                                                   |   |
| Date:  | April 30, 2013 | /s/ Geoffrey Davis                                                                                     |   |
|   |           | Geoffrey Davis                                                                                         |   |
|   |           | Director                                                                                               |   |
|   |           |                                                                                                   |   |
| Date:  | April 30, 2013 | /s/ Richard van den Broek                                                                              |   |
|   |           | Richard van den Broek                                                                                  |   |
|   |           | Director                                                                                               |   |
|   |           |                                                                                                   |   |
| Date:  | April 30, 2013 | /s/ Stephen L. Waechter                                                                                |   |
|   |           | Stephen L. Waechter                                                                                    |   |
|   |           | Director                                                                                               |   |
|   |           |                                                                                                   |   |
| Date:  | April 30, 2013 | /s/ David M. Wurzer                                                                                    |   |
|   |           | David M. Wurzer                                                                                        |   |
|   |           | Director                                                                                               |   |
|   |           |                                                                                                   |   |
| Date:  | April 30, 2013 | /s/ Wayne P. Yetter                                                                                    |   |
|   |           | Wayne P. Yetter                                                                                        |   |
|   |           | Director                                                                                               |   |