EXHIBIT 31.1

Certification of Chief
Executive Officer

I, Carl Spana, certify
that:

| | 1. |  | I have reviewed this
annual report on Form 10-K of Palatin Technologies, Inc.;
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| | 2. |  | Based on my knowledge,
this report does not contain any untrue statement of a material fact or omit to state a
material fact necessary to make the statements made, in light of the circumstances under
which such statements were made, not misleading with respect to the period covered by this
report;
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| | 3. |  | Based on my knowledge, the
financial statements, and other financial information included in this report, fairly
present in all material respects the financial condition, results of operations and cash
flows of the registrant as of, and for, the periods presented in this report;
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| | 4. |  | The registrants
other certifying officer and I are responsible for establishing and maintaining disclosure
controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and
internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and
15d-15(f)) for the registrant and have:
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| |  | (a) |  | Designed such disclosure
controls and procedures, or caused such disclosure controls and procedures to be designed
under our supervision, to ensure that material information relating to the registrant,
including its consolidated subsidiary, is made known to us by others within those
entities, particularly during the period in which this report is being prepared;
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| |  | (b) |  | Designed such internal
control over financial reporting, or caused such internal control over financial reporting
to be designed under our supervision, to provide reasonable assurance regarding the
reliability of financial reporting and the preparation of financial statements for
external purposes in accordance with generally accepted accounting principles;
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| |  | (c) |  | Evaluated the
effectiveness of the registrants disclosure controls and procedures and presented in
this report our conclusions about the effectiveness of the disclosure controls and
procedures, as of the end of the period covered by this report based on such evaluation;
and
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| |  | (d) |  | Disclosed in this report
any change in the registrants internal control over financial reporting that
occurred during the registrants most recent fiscal quarter (the registrants
fourth fiscal quarter in the case of an annual report) that has materially affected, or is
reasonably likely to materially affect, the registrants internal control over
financial reporting; and
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| | 5. |  | The registrants
other certifying officer and I have disclosed, based on our most recent evaluation of
internal control over financial reporting, to the registrants auditors and the audit
committee of the registrants board of directors:
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| |  | (a) |  | All significant
deficiencies and material weaknesses in the design or operation of internal control over
financial reporting which are reasonably likely to adversely affect the registrants
ability to record, process, summarize and report financial information; and
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| |  | (b) |  | Any fraud, whether or not
material, that involves management or other employees who have a significant role in the
registrants internal control over financial reporting.
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Date: September 12, 2006

/s/ Carl Spana

Carl Spana, President and
Chief Executive Officer