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SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549



FORM 10-K



FOR ANNUAL AND TRANSITION REPORTS

PURSUANT TO SECTIONS 13 OR 15(d) OF THE

SECURITIES EXCHANGE ACT OF 1934



|x | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ------------------------------------------------------------------------------------



For the fiscal year ended December 31, 2003



OR



| ̈ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------



For the transition period from
 to



Commission file number 022332



INSITE VISION INCORPORATED

(Exact
name of registrant as specified in its charter)



|                                                              |  |                                    
|------------------------------------------------------------- |  | -----------------------------------
|Delaware                                                      |  | 94-3015807                         
|(State or other jurisdiction ofincorporation or organization) |  | (I.R.S. EmployerIdentification No.)



965 Atlantic Avenue

Alameda, CA 94501

(Address of Principal Executive Offices, including Zip Code)



Registrants telephone number, including area code: (510) 865-8800



Securities registered pursuant to Section 12(b) of the Act:



|                              |  |                                          
|----------------------------- |  | -----------------------------------------
|Title of each class           |  | Name of each exchange on which registered
|Common Stock, $0.01 Par Value |  | American Stock Exchange                  



Securities
registered pursuant to Section 12(g) of the Act:     None



Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period
that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes þ No ̈



Indicate by check mark if
disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and will not be contained, to the best of the registrants knowledge, in definitive proxy or information statements incorporated by reference in
Part III of this Form 10-K or any amendment to this Form 10-K. þ



Indicate by check mark whether the registrant is an accelerated filer (as defined in Rule 12b-2 of the Securities Exchange Act of 1934). Yes ̈No þ



The aggregate market value of registrants Common Stock, $0.01 par value, held by non-affiliates of the Registrant as of June 30, 2004: was
approximately $12,742,170 (based upon the closing sale price of the Common Stock on the last business day of the registrants most recently completed second fiscal quarter). Shares of Common Stock held by each officer and director and by each
person who owns 5% or more of the Common Stock have been excluded from such calculation as such persons may be deemed affiliates. This determination of affiliate status is not necessarily a conclusive determination for other purposes. Number of
shares of Common Stock, $0.01 par value, outstanding as of March 26, 2004: 33,138,778.



DOCUMENTS INCORPORATED BY REFERENCE



Designated portions of the following document are incorporated by reference into this Report on Form 10-K where indicated: portions of the Proxy Statement for the registrants 2004 Annual Meeting of Stockholders
which we expect to be held on June 1, 2004 are incorporated by reference into Part II, Item 5 and Part III of this Report.



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ANNUAL REPORT ON FORM 10-K

FOR THE FISCAL YEAR ENDED DECEMBER 31, 2003



TABLE OF CONTENTS



|           |  |                                                                                                       |  |     
|---------- |  | ----------------------------------------------------------------------------------------------------- |  | ----
|           |  |                                                                                                       |  | Page
|PART I     |  |                                                                                                       |  |     
|Item 1.    |  | Business                                                                                              |  | 1   
|Item 2.    |  | Properties                                                                                            |  | 29  
|Item 3.    |  | Legal Proceedings                                                                                     |  | 29  
|Item 4.    |  | Submission of Matters to a Vote of Security Holders                                                   |  | 30  
|           |  |                                                                                                      
|PART II    |  |                                                                                                       |  |     
|Item 5.    |  | Market for Registrants Common Equity, Related Stockholder Matters and Issuer Purchases of Securities |  | 30  
|Item 6.    |  | Selected Financial Data                                                                               |  | 34  
|Item 7.    |  | Managements Discussion and Analysis of Financial Condition and Results of Operations                 |  | 35  
|Item 7A.   |  | Qualitative and Quantitative Disclosures About Market Risk                                            |  | 42  
|Item 8.    |  | Financial Statements and Supplementary Data                                                           |  | 42  
|Item 9.    |  | Changes in and Disagreements with Accountants on Accounting and Financial Disclosure                  |  | 62  
|Item 9A.   |  | Controls and Procedures                                                                               |  | 63  
|           |  |                                                                                                      
|PART III   |  |                                                                                                       |  |     
|Item 10.   |  | Directors and Executive Officers of the Registrant                                                    |  | 63  
|Item 11.   |  | Executive Compensation                                                                                |  | 64  
|Item 12.   |  | Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters        |  | 64  
|Item 13.   |  | Certain Relationships and Related Transactions                                                        |  | 64  
|Item 14.   |  | Controls and Procedures                                                                               |  | 64  
|           |  |                                                                                                      
|PART IV    |  |                                                                                                       |  |     
|Item 15.   |  | Exhibits, Financial Statement Schedules, and Reports on Form 8-K                                      |  | 64  
|           |  |                                                                                                      
|Signatures |  |                                                                                                       |  | 65  





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Cautionary Statement for purposes of the Safe Harbor provisions of Private Securities Litigation Reform
Act of 1995:



Except for the historical information
contained herein, the discussion in this Annual Report on Form 10-K contains certain forward-looking statements that involve risks and uncertainties, such as statements of our plans, beliefs, objectives, expectations and intentions. The cautionary
statements made in this document should be read as applicable to all related forward-looking statements wherever they appear in this document. Our actual results could differ materially from those discussed herein. Factors that could cause or
contribute to such differences include those discussed below in Risk Factors, as well as those discussed elsewhere herein. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the
date hereof. We undertake no obligation to update any forward- looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events.



PART I



|Item 1. | Business
|------- | --------



THE COMPANY



We are an ophthalmic product development company focused on developing genetically-based technology, for the diagnosis, prognosis and management of glaucoma, as well as ophthalmic pharmaceutical products based on our proprietary
DuraSite® eyedrop-based drug delivery technology.
In addition, we have a retinal program that includes both a therapeutic agent and a retinal drug delivery technology.



We are focusing our commercial efforts and research and development on the following:



| |  | ISV-401, a DuraSite formulation of azithromycin, an antibiotic not currently used in ophthalmology;
| | - | ---------------------------------------------------------------------------------------------------



| |  | targeted market introduction of our OcuGene® glaucoma genetic test based on our ISV-900 technology;
| | - | ---------------------------------------------------------------------------------------------------



| |  | expanding our ISV-900 technology for the diagnosis, prognosis and management of glaucoma;
| | - | -----------------------------------------------------------------------------------------



| |  | ISV-205, a DuraSite formulation for the treatment of glaucoma;
| | - | --------------------------------------------------------------



| |  | ISV-014, a retinal drug delivery device; and
| | - | --------------------------------------------



| |  | treatments for diabetic retinopathy and macular degeneration.
| | - | -------------------------------------------------------------



DuraSite-Based Product and Candidates. Our DuraSite delivery system is a patented eyedrop formulation comprising a cross-linked carboxyl-containing
polymer that incorporates the drug to be delivered to the eye. The formulation is instilled in the cul-de-sac of the eye as a small volume eyedrop and remains in the eye for up to several hours during which time the active drug ingredient is
gradually released. This increased residence time is designed to permit lower concentrations of a drug to be administered over a longer period of time, thereby minimizing the inconvenience of frequent dosing and reducing potential related adverse
side effects. In contrast, conventional eyedrops typically only last a few minutes in the eye and require delivery of a highly concentrated burst of drug and frequent administration to sustain therapeutic levels. DuraSite can be customized to
deliver a variety of compounds with a broad range of molecular weights and other properties.



We have received patent allowances covering extended viscosity and pH ranges of the DuraSite system. These extended ranges will allow a broader range of compounds to be delivered by the system and the additional
patent allowances provide protection until 2016.

The first product utilizing our DuraSite technology, AquaSite® dry eye treatment, was launched as an over-the-counter, or OTC, medication in
1992 by CIBA Vision Ophthalmics, or CIBA Vision, to which



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we have licensed certain co-exclusive rights. In 2000, Global Damon Pharm launched AquaSite in Korea, based on a licensing agreement signed in 1999. In 1999,
we also licensed AquaSite to SSP Co., Ltd., or SSP, for sale in Japan. (See Collaborative and Licensing Agreements for additional information on these agreements.) In connection with our DuraSite development efforts, we have
licensed marketing rights to certain DuraSite-based product candidates to CIBA Vision and Bausch & Lomb Incorporated, or B&L.



Glaucoma Genetics. Our glaucoma genetics program, which is being carried out in collaboration with academic researchers, is focused on discovering
genes that are associated with glaucoma, and the mutations on these genes that cause and regulate the severity of the disease. This genetic information then may be applied to develop new glaucoma diagnostic, prognostic and management tools. The
first of these new tools, OcuGene, our genetic test to determine if an individual has a higher risk of developing a more aggressive form of glaucoma, is focused on targeted market introduction and was first introduced to the medical community at the
end of 2001.



In June 2003, a peer-reviewed study was published
inClinical Genetics titled Association of the Myocilin mt.1 Promoter Variant with the Worsening of Glaucomatous Disease Over Time, (2003: 64: 18-27). The study is based on information gathered at Philadelphia-based Wills Eye
Hospital from 147 patients with primary open-angle glaucoma (POAG) who were followed for an average of approximately 15 years. Investigators conducted analyses that were controlled for various relevant disease-related baseline risk factors,
including age, family history, initial drug treatment, initial surgical treatment, diabetes, gender, myopia and initial disease severity.



The results of this study indicate substantial evidence that the TIGR/MYOC mt.1(+) variant provides a strong marker for accelerated worsening of
both optic disc and visual field measures of glaucoma progression above and beyond other baseline risk factors, stated one of the authors of the study, Jon Polansky, M.D., University of California, San Francisco. Dr. Polansky also acts as our
advisor. Our OcuGene glaucoma genetic test screens for the TIGR/MYOC mt.1(+) variant.



A clinical study published in the September 2001 issue of Clinical Genetics, showed a correlation between the presence of the TIGR promoter region mutation in individuals with primary open-angle glaucoma, or
POAG, and the likelihood of an individual developing a more aggressive form of glaucoma including more visual field damage.



To date, our academic collaborators have identified genes associated with POAG (the most prevalent form of glaucoma in adults), normal tension glaucoma,
juvenile glaucoma and primary congenital glaucoma, or PCG. Our academic collaborators for our glaucoma genetics program include: the University of California, San Francisco, or UCSF; the University of Connecticut Health Center, or UCHC; Institute
National de la Sante et de la Recherche Medicale, or INSERM, the French equivalent of US National Institutes of Health; Okayama University in Japan; and other institutions in North America and Europe. This research, other than what has been
incorporated into our OcuGene test, still must be converted into commercial products.



Business Strategy. Our business strategy is to license promising product candidates and technologies from academic institutions and other companies, to conduct preclinical and clinical testing, if necessary,
and to partner with pharmaceutical companies to complete clinical development and regulatory filings as needed and to produce and market our products. We also have internally developed DuraSite-based product candidates using either non-proprietary
drugs or compounds developed by others for non-ophthalmic indications. As with in-licensed product candidates, we either have or plan to partner with pharmaceutical companies to complete clinical development and commercialization of our own product
candidates.



Corporate Information. Our principle
executive offices are located at 965 Atlantic Avenue, Alameda, California 94501. Our telephone number is (510) 865-8800. We make our periodic and current reports available, free of charge, through our website (http:///www.insitevision.com) under
Investor Relations  SEC Filings as soon as reasonably practicable after such material is electronically filed with the Securities and Exchange Commission.



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Ophthalmic Pharmaceutical Market



The prevalence of eye disease increases disproportionately with age and is ten times greater in persons over the age of 65.
The U.S. Census Bureau projects that the U.S. population over age 65 will increase from 34 million in 1997 to approximately 69 million by the year 2030. We believe that this aging of the U.S. population and similar trends in other developed
countries will contribute to increased demand for new ophthalmic products.



In addition to changing demographics, we believe that recent improvements in medical technology, such as increasingly sophisticated diagnostic techniques, will allow identification of ocular diseases at an earlier
stage, enabling more effective treatments and expanding the range of treatment regimens available to the ophthalmologist. Further, we believe that the emergence of new laser-based procedures to correct certain vision problems has begun to increase
the need for comfortable, extended-release drug therapy during the post-surgical ocular healing process.



According to the Glaucoma Research Foundation, glaucoma is the leading cause of preventable blindness, affecting two to three million people in the U.S.,
and 67 million people worldwide. The prevalence of the disease in first-degree relatives of affected patients has been documented to be as high as seven to ten times that of the general population. Glaucoma also may occur as a complication of
conditions such as diabetes, or as a result of extended steroid use.



The worldwide ophthalmic antibiotic market was anticipated to reach approximately $700.0 million in 2002, according to a study by Frost and Sullivan. The study also anticipated sales of ophthalmic fluoroquinolone products to reach $280.0
million in 2002. The market has been, and we believe will continue to be, impacted by the use of antibiotics in connection with laser-based vision correction procedures.



Age-related macular degeneration, which affects 15 million or more people in the U.S., is the leading cause of severe
blindness in Americans age 60 and above, according to the Macular Degeneration Partnership. Laser treatment and the photo-dynamic therapy introduced in 2000, are the only known therapies, but are effective in only a certain portion of affected
patients. Even with treatment, the disease usually progresses and eventually leads to vision loss.



Also, approximately 10 to 14 million Americans are diabetic and many of them will develop diabetic retinopathy later in their life. According to the
American Diabetes Association, diabetic retinopathy is responsible for 8 percent of the legal blindness in the U.S. and is the leading cause of new cases of blindness in adults 20 to 74 years of age. Laser therapy is effective only in a certain
segment of the diabetic population, and has potential side effects such as loss of peripheral vision, retinal detachment, and loss of vision.



Recent Developments



On December 16, 2003, we sold 142,857 shares of our common stock in a private placement to an accredited investor and received $50,000 in proceeds. On
March 26, 2004, we received approximately $1.8 million, net of placement fees, from the initial closing of a private placement that will yield aggregate gross proceeds of $16.5 million if the final closing occurs. At the initial closing we sold
3,880,000 shares of our common stock at a price of $0.50 per share and warrants to purchase 1,940,000 shares of our common stock at an exercise price of $0.75 per share. The final closing is contingent upon our receiving stockholder approval for the
financing and for an amendment to our Certificate of Incorporation increasing the authorized shares of our common stock by an amount sufficient to enable us to issue the shares and warrants contemplated in the final closing and other standard
closing conditions. See Item 5. Market for Registrants Common Equity, Related Stockholder Matters and Issuer Purchases of Securities  Recent Sales of Unregistered Securities for a further description of these transactions.



On December 31, 2003, we entered into a settlement agreement
with Xmark Funds, L.P. et al, or Xmark, related to a complaint filed against us by Xmark. As part of the settlement we paid Xmark $10,000 and issued warrants to purchase 250,000 shares of our Common Stock at an exercise price of $0.58 per share that
expire on December 31, 2006. See Item 5. Market for Registrants Common Equity, Related Stockholder Matters and Issuer Purchases of Securities  Recent Sales of Unregistered Securities for a further description of this
transaction.



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Products and Product Candidates



The following table summarizes the current status of our principal products and product candidates. A more detailed
description of each product and product candidate follows the table. There can be no assurance that any of the listed products or product candidates will progress beyond its current state of development, receive necessary regulatory approval or be
successfully marketed.



Products and Product Candidates



|                                             |  |                                                                                                       |  |                                                                                                   |  |                                              
|-------------------------------------------- |  | ----------------------------------------------------------------------------------------------------- |  | ------------------------------------------------------------------------------------------------- |  | ---------------------------------------------
|Product                                      |  | Indications                                                                                           |  | Anticipated Benefits                                                                              |  | Status(1)                                    
|                                             |  |                                                                                                       | 
|Glaucoma Genetics                            |  |                                                                                                       |  |                                                                                                   |  |                                              
|                                             |  |                                                                                                       | 
|OcuGene  Glaucoma Genetic Test              |  | Glaucoma severity (TIGR gene)                                                                         |  | Determine disease severity among glaucoma patients                                                |  | Marketed                                     
|                                             |  |                                                                                                       | 
|PCG  Primary Congenital Glaucoma Test       |  | Glaucoma detection in infants                                                                         |  | Patient identification to allow early treatment before complications and irreversible vision loss |  | Pre-commercialization(2)                     
|                                             |  |                                                                                                       | 
|ISV  900                                    |  | Glaucoma prognostic/ diagnostic                                                                       |  | Identify new genetic markers to detect disease susceptibility and determine disease severity      |  | Research                                     
|                                             |  |                                                                                                       | 
|Glaucoma Product Candidates                  |  |                                                                                                       |  |                                                                                                   |  |                                              
|                                             |  |                                                                                                       | 
|ISV  205                                    |  | Steroid-induced intraocular pressure elevation, glaucoma                                              |  | Treat/prevent disease progression                                                                 |  | Phase 2(b) completed                         
|                                             |  |                                                                                                       | 
|Other Topical Product Candidates and Product |  |                                                                                                       |  |                                                                                                   |  |                                              
|                                             |  |                                                                                                       | 
|ISV  401                                    |  | Bacterial infection including ophthalmia neonatorum                                                   |  | Broad spectrum antibiotic with reduced dosing frequency                                           |  | Phase 3(3)                                   
|                                             |  |                                                                                                       | 
|ISV  403                                    |  | Bacterial infection                                                                                   |  | Fourth generation fluoroquinolone antibiotic with reduced dosing frequency                        |  | Phase 1(4) Sold to Bausch & Lomb Incorporated
|                                             |  |                                                                                                       | 
|ISV  205                                    |  | Inflammation and analgesia                                                                            |  | Reduced dosing frequency                                                                          |  | Preclinical                                  
|                                             |  |                                                                                                       | 
|AquaSite                                     |  | Dry eye                                                                                               |  | Reduced dosing frequency and extended duration of action                                          |  | Marketed (OTC)                               
|                                             |  |                                                                                                       | 
|Retinal Device                               |  |                                                                                                       |  |                                                                                                   |  |                                              
|                                             |  |                                                                                                       | 
|ISV  014                                    |  | Retinal drug delivery device for potential treatment of diabetic retinopathy and macular degeneration |  | Non-surgical delivery of drugs to the retina                                                      |  | Research                                     



|1) | All products except OcuGene, ISV-900, AquaSite and ISV-014 are expected to be prescription
pharmaceuticals. As denoted in the table, Preclinical follows the research stage and indicates that a specific compound is being tested in preclinical studies in preparation for filing an investigational new drug application, or IND. For
a description of preclinical trials, IND, Phase 1, Phase 2 and Phase 3 clinical trials and New Drug Application, or NDA, see Government Regulation.
|-- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|2) | A prognostic technology has been developed and plans for use in screening a limited
population prior to being available for a broader market will be dependent upon available funding.
|-- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|3) | Phase 2 testing is completed for ISV-401 and Phase 3 clinical trials are anticipated to begin
in the second quarter of 2004.
|-- | ----------------------------------------------------------------------------------------------------------------------------



|4) | The Phase 1 testing is completed and the program was sold to Bausch & Lomb in December
2003. Further clinical development will be conducted by Bausch & Lomb.
|-- | -------------------------------------------------------------------------------------------------------------------------------------------------------------



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Glaucoma Genetics



According the Glaucoma Research Foundation, glaucoma is the leading cause of preventable blindness in the U.S., affecting an estimated two to three
million people. The most prevalent form of glaucoma in adults is POAG. Other forms of the disease include PCG, a leading cause of blindness in infants, and juvenile glaucoma that affects children and young adults.



Often called the sneak thief of sight because of its lack of
symptoms, glaucoma is believed to result when the flow of fluid through the eye is impaired. This may lead to elevated intraocular pressure or IOP, which increases pressure on the optic nerve and can cause irreversible vision loss if left untreated.
However, one form of glaucoma, normal or low-tension glaucoma, is associated with individuals who have normal eye pressure. It is estimated that one-third of U.S. glaucoma patients and three-quarters of glaucoma patients in Japan have this form of
the disease, based on a study conducted by Dr. Kitazawa in Japan. These patients cannot be identified with standard glaucoma screening tests that only measure a patients eye pressure and these patients usually incur visual field loss before
they are diagnosed.



ISV-900. There is accumulating
evidence that genetic predisposition is a major factor in the development of several forms of glaucoma. According to the Glaucoma Research Foundation, a family history of POAG increases the risk of developing glaucoma by 4 to 9 times that of the
general population. We have formed research collaborations with scientists at institutions located in North America, Europe and Japan both to identify the genes associated with different forms of glaucoma and to build a database of information on
how these genes affect the progression of the disease in different populations.



Researchers with whom we collaborate have identified several disease-causing, or modifying, genes related to POAG including TIGR/MYOC, OPTN, OCLM and APOE. Additional research has revealed mutations in the CYP1B1 gene
that are related to PCG. We have obtained exclusive worldwide licenses for the rights to commercialize certain research related to the TIGR gene and associated mutations from the Regents of the University of California, the CYP1B1 gene and
associated mutations from UCHC and APOE, as it interacts with TIGR, from INSERM.



We currently hold licenses to patents issued on the TIGR cDNA, TIGR antibodies, methods for the diagnosis of glaucoma using the TIGR technology and methods for the diagnosis of glaucoma using the CYP1B1 technology.
Additional patents related to the ISV-900 program are currently pending and if issued will be included in the licenses we hold.



OcuGene. Current glaucoma tests are often unable to detect the disease before substantial damage to the optic nerve has
occurred. Gene-based tests may make it possible to identify patients at risk and initiate treatment before permanent optic nerve damage and vision loss occurs. Our ISV-900 program is intended to discover the appropriate genetic markers for certain
forms of glaucoma and to incorporate those markers into prognostic, diagnostic and management tools. The first version of these tests, OcuGene, has been developed and the product was commercially launched at the end of 2001. However, development of
additional clinical data will be necessary to support the market utility of this product. We anticipate that as further research identifies new genes, and additional mutations, we will bring these to market as additional tests.



In December 2002, we entered into an agreement with Società Industria
Farmaceutica Italiana (SIFI) that grants them the exclusive right to manufacture/perform, distribute and market OcuGene in Italy for eight years. SIFI introduced the OcuGene test at two Italian ophthalmic meetings in late 2003, and is currently
evaluating the market opportunity and feasability to support a product launch in the second half of 2004.



Glaucoma Product Candidates



ISV-205. Our ISV-205 product candidate contains the drug diclofenac formulated in the DuraSite sustained-release delivery vehicle. Diclofenac is a non-steroidal anti-inflammatory drug or NSAID currently used to treat ocular
inflammation. NSAIDs can block steroid-induced IOP elevation by inhibiting the production of the TIGR protein that appears to affect the fluid balance in the eye. Our ISV-205 product candidate delivers concentrations of diclofenac that have been
shown in cell culture systems to inhibit the production of the TIGR protein.



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We successfully completed a Phase 2a clinical study in 1999 that evaluated the efficacy of two
concentrations of diclofenac. Analysis of the data from this study indicates that ISV-205 was safe and associated with a 75% reduction in the number of subjects with clinically significant IOP elevation following steroid use.



In 2001 we completed a Phase 2b clinical study that was conducted in 233
subjects with ocular hypertension. Genetic information was collected on the subjects using our ISV-900 technology and the subjects were dosed twice daily for six months with ISV-205. Our ISV-900 technology detected the TIGR mt-1 or mt-11 mutations
in approximately 70% of the ocular hypertensives participating in the study. In patients with the TIGR mutations, a 0.1% formulation of our ISV-205 product candidate was statistically significantly more effective than placebo in lowering intraocular
pressure (IOP) (p=0.008). These effects were not seen to the same extent in patients without the TIGR mutations. ISV-205 was similar to placebo in ocular safety and comfort in all patients. We are planning further clinical studies before filing for
product approval with the U.S. Food and Drug Administration, or FDA. However, we cannot assure you that similar clinical results will be achieved. Also, initiation of such studies will require us to obtain additional funding either from a strategic
partner or from investors.



Other potential indications for
ISV-205 may include glaucoma prevention, analgesia and anti-inflammatory indications. Co-exclusive rights, in the U.S., to develop, manufacture, use and sell ISV-205 to treat non-glaucoma indications of inflammation and analgesia, were licensed to
CIBA Vision in May 1996.



Other Topical Product Candidates and Marketed
Product



ISV-401.We have developed a topical
formulation of the antibiotic, azithromycin to treat bacterial conjunctivitis and other infections of the outer eye. Azithromycin has a broad spectrum of antibiotic activity and is widely used to treat respiratory and other infection in its oral and
parenteral forms. The eye drop of 1% azithromycin (ISV-401) is formulated to deliver sufficient tissue concentrations over a 5-day dosing period using our proprietary DuraSite technology that enables superior bactericidal activity against most
common ocular pathogens and pseudomonas. The key advantages of ISV-401 include a significantly reduced dosing regimen (6 doses vs. 36 doses for comparable products), the high and persistent levels of azithromycin achieved in the tissues of the eye
and its wide spectrum of activity. Phase 1 and 2 studies have shown that ISV-401 is well tolerated and effective. ISV-401 also has broad patent protection (see Risk Factors - Our business depends upon our proprietary rights, and we may not
be able to adequately protect, enforce or secure our intellectual property rights).



ISV-401 has been formulated to meet the regulatory requirements for both a United States and a global product. Our marketing emphasis will focus on pediatricians, general practitioners, and ophthalmologists.
Pediatricians and general practice physicians write more than 65% of total prescriptions for ophthalmic antibiotics. We expect that if and when it is released, use of ISV-401 by ophthalmologists will grow steadily as the product, in our estimation,
will be positioned to compete favorably with the newer 4thgeneration fluoroquinolones for antibacterial coverage.
Further, ISV-401 possesses the advantage of reduced dosing frequency that we believe may ultimately increase patient compliance and reduce the likelihood of the development of bacterial resistance. Additionally, we believe ISV-401 may be used in
additional indications, including surgery, opthalmia neonatorium and blepharitis. Marketing of ISV-401 will require us first to obtain additional funding either from a strategic partner or from investors.



Product safety and efficacy have been demonstrated, respectively, in Phase 1
and Phase 2 clinical trials. As a result of our End of Phase 2 Meeting with the FDA, we intend to execute two pivotal Phase 3 clinical trials, the first of which is planned to begin in the second quarter of 2004. We anticipate conducting
the trials in both the United States and internationally to permit aggressive enrollment of the subjects, including both children and adults, necessary to complete the studies. We further anticipate that the primary endpoints of both trials will be
microbial eradication and clinical cure.



We have secured a
source for the active ingredient and have a contract-manufacturing site for production of clinical trial supplies and registration batches. The supplies are being manufactured under the supervision of our personnel. We are planning to begin the
manufacture of the registration batches needed to support the filing of the NDA at this contract facility in the second quarter of 2004. We anticipate that our contract manufacturing facility will be ready for inspection by the FDA at the time of
our NDA submission. It should be noted that manufacturing plans are subject to delays and unanticipated interruptions.



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ISV-403 is a formulation of a fluoroquinolone in the DuraSite system. Fluoroquinolones are
effective against gram-positive and gram-negative bacteria including Pseudomonas, and are often used as prophylaxis during ophthalmic surgery. Based on recently conducted preclinical testing, it was determined that this is a fourth-generation
fluoroquinolone, which has expanded bacterial sensitivities and may be effective against the bacteria that have developed resistance to prior generation fluoroquinolones and other antibiotics. In addition, based on preclinical studies, we believe
the ISV-403 formulation may allow for reduced dosing frequency compared to other fluoroquinolone formulations currently on the market. In February 2003 we filed an Investigational New Drug Application, or IND, with the FDA and in April 2003 we began
a Phase 1 clinical trial of ISV-403. In June 2003 the dosing for the study was completed. In December 2003 we sold the ISV-403 product candidate to Bausch & Lomb, who had licensed the product candidate from us in August 2002. Bausch & Lomb
is responsible for the further clinical development of the product.



AquaSite. The first product utilizing our DuraSite technology was introduced to the OTC market in the U.S. in October 1992 by CIBA Vision. We receive a royalty on sales of AquaSite by CIBA Vision. The product contains the DuraSite
formulation and demulcents for the symptomatic treatment of dry eye. In March 1999, we licensed AquaSite to Global Damon Pharm, a Korean company. The license is royalty-bearing, has a term of 10 years and is exclusive in the Republic of Korea. In
August 1999, we entered into a ten year royalty-bearing license with SSP for the sales and distribution of AquaSite in Japan.



Retinal Device



Ophthalmic conditions that involve retinal damage include macular degeneration, which according to the American Macular Degeneration Foundation affects 10
million or more people in the U.S., and diabetic retinopathy, a common side effect of diabetes. According to the National Diabetes Education Foundation, approximately 16 million people in the U.S. are diabetics. Both macular degeneration and
diabetic retinopathy can lead to irreversible vision loss and blindness. Current treatment of retinal diseases, including diabetic retinopathy and macular degeneration, generally involves surgery, laser and photo-dynamic therapies, each of which can
lead to loss of vision, retinal detachment, infection and may not slow the progression of the disease. Currently, there is no effective drug therapy for these conditions.



Retinal Delivery Device. ISV-014 is one of our technology platforms and consists of a device for the
controlled, non-surgical delivery of ophthalmic drugs to the retina and surrounding tissues. During 2002, we continued to enhance the device and performed in vivo experiments delivering products with a variety of molecular sizes to retinal tissues.
The combination of this device technology with viral or small molecule drug platforms may permit long term delivery of therapeutic agents to treat several retinal diseases, including diabetic retinopathy and macular degeneration, most of which
cannot be effectively treated at the present time.



The ISV-014
device consists of a handle with a distal platform that is placed against the surface of the eye. A small needle connected to a drug reservoir is extended from the platform into the tissues of the eye. Once in place, a metering mechanism controls
the amount and rate that the drug is injected into the tissue. This produces a highly localized depot of drug inside the ocular tissues. By controlling both the distance and direction that the needle protrudes, the device greatly reduces the chance
that the needle will penetrate through the sclera of the eye into the underlying tissues, which are easily damaged. We have filed for two patents related to the device and one patent has been allowed. We are currently pursing the licensing of this
technology to third parties.



Collaborative, Licensing and Service
Agreements



As part of our business strategy, we have
entered into, and will continue to pursue additional research collaborations, licensing agreements and corporate collaborations. However, there can be no assurance that we will be able to negotiate acceptable collaborative or licensing agreements,
or that our existing collaborations will be successful, will be renewed or will not be terminated.



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Bausch and Lomb Incorporated. On December 30, 2003, we completed the sale of our drug candidate
ISV-403 for the treatment of ocular infections to Bausch & Lomb Incorporated or Bausch & Lomb, pursuant to an ISV-403 Purchase Agreement dated December 19, 2003 (the Purchase Agreement) and a License Agreement dated December 30,
2003 (the License Agreement, and collectively, the Asset Sale).



Under the terms of the Purchase Agreement, we received a cash payment from Bausch & Lomb in the amount of $1,500,000 and reimbursement of certain ISV-403 product development expenses as well as budgeted expenses
in furtherance of ISV-403 product development actually incurred between November 1, 2003 and the closing of the Asset Sale, as well as reimbursement for development support obligations for a period of time subsequent to closing. We will also receive
a percentage of future ISV-403 net product sales, if any, in all licensed countries, ending upon the later of the expiration of the patent rights underlying ISV-403 or ten years from the date of the first ISV-403 product sale by Bausch & Lomb.
Bausch & Lomb has assumed all future ISV-403 development and commercialization expenses and, following a transfer period, will be responsible for all development activities, with our assistance as appropriate. In addition, the August 2002
ISV-403 licensing agreement and the related Series A-1 Preferred Stock purchase agreement between Bausch & Lomb and us has been terminated and Bausch & Lomb has returned to us for cancellation all shares of our Series A-1 Preferred Stock we
previously issued to Bausch & Lomb. Under the Purchase Agreement, we also have certain potential indemnification obligations to Bausch & Lomb in connection with the Asset Sale.



The License Agreement provides Bausch & Lomb a license under certain of our patents related to our DuraSite delivery
system for use with ISV-403 and under other non-patent intellectual property used in ISV-403. The License Agreement provides for Bausch & Lomb to complete development of the SS734 fluoroquinolone products that combine certain compounds, we
licensed from SSP, Co., Ltd., or SSP, with the DuraSite delivery system and to commercialize any such products. The patent license is exclusive (even as to us) in the particular field of developing, testing, manufacturing, obtaining regulatory
approval of, marketing, selling and otherwise disposing of such products. The license of non-patent intellectual property granted to Bausch & Lomb is nonexclusive.



In connection with the Asset Sale, we also assigned to Bausch & Lomb a certain agreement between SSP and us under which
we were licensed to commercialize SSPs SS734 fluoroquinolone. Because that agreement also included a license from us to SSP under certain patents relating to DuraSite that we did not sell to Bausch & Lomb, the assignment of the agreement
to Bausch & Lomb excluded the assignment of our obligations and rights as the licensor of such patents. Instead, we entered into a new license agreement with SSP reflecting our original rights and obligations as the licensor of the DuraSite
patents to SSP.



Societa Industria Farmaceutica Italiana
 S.P.A. (SIFI) In December 2002, we entered into a exclusive distribution agreement with SIFI for OcuGene in Italy. The distribution agreement grants SIFI the right to manufacture, directly or indirectly, distribute, perform, market, sell
and promote our OcuGene glaucoma genetic test in Italy. Over the initial eight-year term of the agreement SIFI will pay us a fee for each test conducted. The agreement may be extended by SIFI for additional two year periods if certain sales targets
are met during such periods.



Quest Diagnostics
Incorporated. In November 2002, we extended an exclusive laboratory service agreement with Quest Diagnostics Incorporated, or Quest, for our OcuGene test in the U.S. Under this agreement, we pay Quest for each OcuGene test that they perform.



CIBA Vision Ophthalmics.In October 1991, we entered
into license agreements with CIBA Vision (the CIBA Vision Agreements), which granted CIBA Vision certain co-exclusive rights to manufacture, have manufactured, use and sell, in the U.S. and Canada: fluorometholone and tear replenishment
products utilizing the DuraSite technology, ISV-205 for non-glaucoma indications, and ToPreSite®, a product candidate for ocular inflammation/infection (the development of which is currently not being pursued by us or Ciba Vision).



INSTITUTE NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM).In December 1999, we entered into a license agreement with INSERM granting us certain exclusive rights for



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the diagnostic, prognostic and therapeutic uses of a gene for chronic open angle glaucoma. We paid a licensing fee and will make royalty payments on future
product sales, if any.



University of Connecticut Health
Center (UCHC). In July 1997, we exercised our option granted pursuant to a research agreement with UCHC to obtain certain exclusive rights from UCHC for diagnostic uses of the newly discovered gene for PCG. Under the agreement, we will pay a
licensing fee and will make royalty payments on future product sales, if any.



In December 2001, we entered into an agreement whereby we exercised our option granted pursuant to a research agreement with UCHC to obtain certain exclusive rights from UCHC for diagnostic uses of the Optineuron gene
and associated mutations. Under this agreement, we will pay a licensing fee and will make royalty payments on future product sales, if any.



UC Regents. In March 1993, we entered into a license agreement with the UC Regents granting us certain exclusive rights for the development of
ISV-205 and, in August 1994, the parties entered into another license agreement granting us certain exclusive rights for the use of a nucleic acid sequence that codes for a protein associated with glaucoma. Under both agreements, we paid initial
licensing fees, share sub-licensing fees we receive, if any, and will make royalty payments to the UC Regents on future product sales, if any.



Columbia Laboratories, Inc. In February 1992, we entered into a cross-license agreement (the Columbia Agreement) with Columbia
Laboratories, Inc., or Columbia, in which Columbia licensed to us certain exclusive rights to a polymer technology upon which DuraSite is based. This license permits us to make, use and sell products using such polymer technology for non-veterinary
ophthalmic indications in the over-the-counter and prescription markets in North America and East Asia (the Columbia Territory), and in the prescription market in countries outside the Columbia Territory. In exchange, we granted Columbia
a license with certain exclusive rights to sublicense and use certain DuraSite technology in the over-the-counter market outside the Columbia Territory. In addition, we also granted Columbia a license with certain exclusive rights to DuraSite
technology in the veterinary field. Under certain circumstances, certain of the licenses in the Columbia Agreement become non-exclusive. Subject to certain rights of early termination, the Columbia Agreement continues in effect until the expiration
of all patents covered by the DuraSite technology to which Columbia has certain rights.



Global Damon Pharm and Kukje Pharma Ind. Co., Ltd.In March 1999, we entered into a royalty-bearing license agreement with Global Damon Pharm, or Global Damon, a Korean company, to be the exclusive distributor
of AquaSite in the Republic of Korea. Concurrently, we entered into a manufacturing agreement with Kukje Pharma Ind. Co., Ltd., or Kukje, a Korean company, to produce the AquaSite to be sold by Global Damon.



SSP Co., Ltd. In April 2001, we entered into a royalty-bearing license
agreement with SSP Co., Ltd, or SSP, for two fourth-generation fluoroquinolones, one of which is the active ingredient in ISV-403. We have worldwide development and marketing rights except for Japan, which were retained by SSP, and will share the
rights with SSP in Asia. We subsequently assigned our rights under this agreement for the active ingredient in ISV-403 to Bausch & Lomb.



In August 1999, we entered into an exclusive license agreement with SSP to be the exclusive manufacturer and distributor of AquaSite in Japan. In
addition, we will be the sole supplier to SSP of some of the key ingredients necessary for the manufacture of AquaSite.



Other.As part of our basic strategy, we continually pursue agreements with other companies, universities and research institutions concerning the
licensing of additional therapeutic agents and drug delivery technologies to complement and expand our family of proprietary ophthalmic products as well as collaborative agreements for the further development and marketing of our current products
and product candidates. We intend to continue exploring licensing and collaborative opportunities, though there is no certainty that we can successfully enter into, or maintain, any such agreements.



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Patents and Proprietary Rights



Patents and other proprietary rights are important to our business. Our policy is to file patent applications seeking to
protect technology, inventions and improvements to our inventions that we consider important to the development of our business. Additionally, we assist UC Regents, UCHC and INSERM in filing patent applications seeking to protect inventions that are
the subject of our agreements with those institutions. We also rely upon trade secrets, know-how, continuing technological innovations and licensing opportunities to develop and maintain our competitive position. Our DuraSite drug delivery products
are made under patents and applications, including three U.S. patents, owned by Columbia and exclusively licensed to us in the field of human ophthalmic applications. In addition, we have filed a number of patent applications in the U.S. relating to
our DuraSite technology. Of these applications, six U.S. patents have been issued. Of the patent applications we have licensed from the UC Regents, twelve U.S. patents have issued. Of the patent applications licensed from UCHC covering the diagnosis
of PCG, five U.S. patents have been issued. We have three patent applications on file for our retinal programs and four U.S. patents on our retinal drug delivery device have been issued. Three patent applications have been filed related to our
antibiotic programs, and four U.S. patents have been issued. Several other patent applications by us and by the UC Regents, UCHC and INSERM relating to the foregoing and other aspects of our business and potential business are also pending. Foreign
counterparts of the InSite patents as well as the licensed patents of certain of these applications exist in many countries.



The patent positions of pharmaceutical companies, including ours, are uncertain and involve complex legal and factual questions. In addition, the coverage
claimed in a patent application can be significantly reduced before a patent is issued. Consequently, we do not know whether any of our pending patent applications will result in the issuance of patents or if any of our patents will provide
significant proprietary protection. Since patent applications are maintained in secrecy until patents issue in the U.S., or such patents are published by foreign regulatory authorities, we cannot be certain that we or any licensor was the first to
file patent applications for such inventions or that patents issued to our competitors will not block or limit our ability to exploit our technology. Moreover, we might have to participate in interference proceedings declared by the U.S. Patent and
Trademark Office to determine priority of invention, which could result in substantial cost to us, even if the eventual outcome were favorable. There can be no assurance that our patents will be held valid or enforceable by a court or that a
competitors technology or product would be found to infringe such patents.



A number of pharmaceutical companies and research and academic institutions have developed technologies, filed patent applications or received patents on various technologies that may be related to our business. Some
of these technologies, applications or patents may conflict with our technologies or patent applications. This conflict could limit the scope of the patents, if any, that we may be able to obtain or result in the denial of our patent applications.
In addition, if patents that cover our activities have been or are issued to other companies, there can be no assurance that we would be able to obtain licenses to these patents, at all, or at a reasonable cost, or be able to develop or obtain
alternative technology.



In addition to patent protection, we
also rely upon trade secret protection for our confidential and proprietary information. There can be no assurance that others will not independently develop substantially equivalent proprietary information and techniques or otherwise gain access to
our trade secrets, that such trade secrets will not be disclosed or that we can effectively protect our rights to unpatented trade secrets.



We believe our drug delivery technology may expand the ophthalmic pharmaceutical market by permitting the novel use of drugs for ophthalmic indications
that are currently used or being developed for non-ophthalmic indications. However, we may be required to obtain licenses from third parties that have rights to these compounds in order to conduct research, to develop or to market products that
contain such compounds. There can be no assurance that such licenses will be available on commercially reasonable terms, if at all.



Research and Development



On December 31, 2003, our research and development staff numbered 14 people, of whom 6 have Ph.D.s. In 2003, our research and development expenses were
$4.4 million, including the expenses related to contract research activities for which we received $128,000 from Bausch & Lomb. In 2002, our research and development expenses, including third party research we sponsored, were $7.1 million, of
which $166,000 was funded by



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third parties. In 2001, our research and development expenses, including third party research we sponsored, were $7.3 million, of which $0.7 million was
funded by Pharmacia as part of the ISV-205 license.



Manufacturing



We have no experience or facilities for the manufacture
of products for commercial purposes and we currently have no intention of developing such experience or implementing such facilities. We have a pilot facility, licensed by the State of California, to produce potential products for Phase 1 and some
of our Phase 2 clinical trials. However, as stated above, we have no large-scale manufacturing capacity and we rely on third parties for supplies and materials necessary for all of our Phase 3 clinical trials. If we should encounter delays or
difficulties in establishing and maintaining our relationship with qualified manufacturers to produce, package and distribute our finished products, then clinical trials, regulatory filings, market introduction and subsequent sales of such products
would be adversely affected.



We contract with a third party to
assemble the sample collection kits used in our OcuGene glaucoma genetic test. If our assembler should encounter significant delays or we have difficulty maintaining our existing relationship, or in establishing a new one, our sales could be
adversely affected.



Marketing and Sales



We have developed a limited marketing and sales organization focused on the
targeted introduction of OcuGene and we are primarily using external marketing and sales resources that include:



| |  | marketing consultants;
| | - | ----------------------



| |  | a network of key ophthalmic clinicians; and
| | - | -------------------------------------------



| |  | other resources with ophthalmic expertise.
| | - | ------------------------------------------



We are evaluating expansion of our external marketing and sales resources to support our continuing OcuGene efforts. Potential resources being evaluated
include:



| |  | contract sales forces;
| | - | ----------------------



| |  | co-marketing and co-promotion arrangements in the U.S.; and
| | - | -----------------------------------------------------------



| |  | licensing arrangements with companies outside of the U.S.
| | - | ---------------------------------------------------------



We do not currently plan on establishing a dedicated sales force or a marketing organization for our other product candidates.



We have also entered into corporate collaborations, and we plan to enter into
additional collaborations with one or more additional pharmaceutical companies, to market our other products. We may not be able to conclude or maintain such arrangements on acceptable terms, if at all.



Our current collaborators include:



CIBA Vision. In 1991, we entered into a co-exclusive rights agreement
to market the AquaSite product in the U.S. and Canada. Additionally, in May 1996, we granted CIBA Vision a co-exclusive U.S. license for ISV-205 for non-glaucoma indications, and co-exclusive marketing rights within the U.S. to sell and use
ToPreSite, a product candidate that currently is not being pursued. CIBA Vision is using our trademark, under license, for AquaSite dry eye treatment and our patents are identified on the AquaSite packaging. We received a one-time licensing fee and
are entitled to royalties based on net sales of the products, if any.



Global Damon and Kukje.In March 1999, we entered into a royalty-bearing licensing agreement with Global Damon, a Korean company, to be the exclusive distributor of AquaSite in the Republic of Korea. Concurrently, we entered into a
manufacturing agreement with Kukje, a Korean company, to produce the AquaSite to be sold by Global Damon.



SSP Co., Ltd. In April 2001, we entered into an exclusive licensing agreement with SSP for two fluoroquinolone compounds, one of which is
incorporated into ISV-403. We have exclusive marketing rights for the world except for Japan, which SSP retained, and shared rights with SSP in the rest of Asia. In December 2003 we assigned our rights under this agreement to the compound
incorporated into ISV-403 to



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Bausch & Lomb. In August 1999, we entered into an exclusive licensing agreement with SSP to be the exclusive manufacturer and distributor of AquaSite in
Japan. We will be the sole supplier to SSP for certain key ingredients necessary for the manufacture of AquaSite.



Bausch & Lomb. In December 2003, we sold our ISV-403 product candidate to Bausch & Lomb. Bausch & Lomb has the exclusive marketing
rights for the world except for Japan, which were retained by SSP, and shared rights in the rest of Asia with SSP. Bausch & Lomb also has also assumed the development and manufacturing responsibilities for the ISV-403 formulation for their sales
and distribution.



SIFI. In December 2002, we entered
into an exclusive licensing agreement with SIFI for OcuGene. SIFI has the exclusive right to manufacture/perform, distribute and market OcuGene in Italy. We provide SIFI with access to technical information related to OcuGene and provide them access
to any marketing materials we develop with respect to OcuGene to aid them in their sales and distribution efforts.



Competition



We have many competitors in the U.S. and abroad. These companies include ophthalmic-oriented companies that market a broad portfolio of products, as well
as large integrated pharmaceutical companies that market a limited number of ophthalmic pharmaceuticals in addition to many other pharmaceuticals. Many of these companies have substantially greater financial, technical, marketing and human resources
than we do and may succeed in developing technologies and products that are more effective, safer or more commercially accepted than any which we have developed or are developing. These competitors may also succeed in obtaining cost advantages,
patent protection or other intellectual property rights that would block our ability to develop our potential products, or may obtain regulatory approval for the commercialization of their products more rapidly or effectively than we do. The
ophthalmic prescription pharmaceutical market in the U.S. is dominated by six companies: Allergan Pharmaceuticals, a division of Allergan, Inc.; Alcon Laboratories, Inc., a division of Nestle Company; Bausch and Lomb; CIBA Vision, a division of
Novartis Ltd.; Merck, Sharp & Dohme, a division of Merck & Co., Inc.; and Pfizer, Inc. It is very difficult for smaller companies, such as ours, that do not have large and well-developed research and development, and sales and marketing
staffs, to successfully develop and market products.



We
believe there will be increasing competition from new products entering the market that are covered by patents and, to a lesser degree, from pharmaceuticals that become generic. We are aware of certain products manufactured or under development by
competitors that are used for the treatment of certain ophthalmic indications we have targeted for product development. Our competitive position will depend on our ability to develop enhanced or innovative pharmaceuticals, maintain a proprietary
position in our technology and products, obtain required U.S. and foreign governmental approvals on a timely basis, attract and retain key personnel and enter into effective collaborations for the manufacture and marketing of our products.



Over the longer term, our, and our partners, ability to
successfully market our current products, and product candidates, expand their usage and bring new products to the marketplace, will depend on many factors, including the degree of patent protection afforded to particular products, and obtaining
approval from managed care and governmental organizations to purchase or reimburse for the purchase of our products.



Government Regulation



The manufacturing and marketing of our products and our research and development activities are subject to regulation by numerous governmental authorities
in the U.S. and other countries. In the U.S., drugs are subject to rigorous FDA regulation. The Federal Food, Drug and Cosmetic Act and regulations promulgated thereunder govern the testing, manufacture, labeling, storage, record keeping, approval,
advertising and promotion in the U.S. of our products. In addition to FDA regulations, we are also subject to other federal and state regulations such as the Occupational Safety and Health Act and the Environmental Protection Act. Product
development and approval within this regulatory framework take a number of years and involve the expenditure of substantial resources.



While the FDA currently does not regulate genetic tests, it has stated that it has the right to do so, and there can be no assurance that the FDA will not
seek to regulate such tests in the future. If the FDA



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should require that genetic tests receive FDA approval prior to their use, there can be no assurance such approval would be received on a timely basis, if at
all. The failure to receive such approval could require us to develop alternative testing methods, which could result in the delay of such tests reaching the market, if at all. Such a delay could materially harm our business.



The steps required before a pharmaceutical agent may be marketed in the U.S.
include:



| |  | preclinical laboratory and animal tests;
| | - | ----------------------------------------



| |  | submission to the FDA of an IND;
| | - | --------------------------------



| |  | adequate and well-controlled human clinical trials to establish the safety and efficacy of the drug;
| | - | ----------------------------------------------------------------------------------------------------



| |  | the submission of an NDA or Product License Application (PLA) to the FDA; and
| | - | -------------------------------------------------------------------------------



| |  | the FDA approval of the NDA or PLA, prior to any commercial sale or shipment of the drug.
| | - | -----------------------------------------------------------------------------------------



In addition to obtaining FDA approval for each product, each domestic drug manufacturer and facility must be registered
with, and approved by, the FDA. Drug product manufacturing establishments located in California also must be licensed by the State of California in compliance with separate regulatory requirements.



Preclinical tests include laboratory evaluation of product chemistry and
animal studies to assess the potential safety and efficacy of the product and its formulation. The results of the preclinical tests are submitted to the FDA as part of an IND and, unless the FDA objects, the IND will become effective 30 days
following its receipt by the FDA.



Clinical trials involve the
administration of the drug to healthy volunteers or to patients under the supervision of a qualified principal investigator. Clinical trials are conducted in accordance with protocols that detail the objectives of the study, the parameters to be
used to monitor safety, and the efficacy criteria to be evaluated. Before any clinical trial can commence, each protocol is submitted to the FDA as part of the IND. Each clinical study is conducted under the auspices of an independent Institutional
Review Board that considers, among other things, ethical factors and the rights, welfare and safety of human subjects.



Clinical trials are typically conducted in three sequential phases, but the phases may involve multiple studies and may overlap. In Phase 1, the initial
introduction of the drug into human subjects, the drug is tested for safety (adverse effects), dosage tolerance, metabolism, distribution, excretion and clinical pharmacology. Phase 2 involves studies in a limited patient population to (i) determine
the efficacy of the drug for specific targeted indications, (ii) determine dosage tolerance and optimal dosage and (iii) identify possible adverse effects and safety risks. When a compound is found to be effective and to have an acceptable safety
profile in Phase 2 evaluations, Phase 3 trials are undertaken to further evaluate clinical efficacy and to further test for safety within an expanded patient population at multiple clinical study sites. The FDA reviews both the clinical plans and
the results of the trials and may discontinue the trials at any time if there are significant safety issues.



The results of the preclinical studies and clinical studies are submitted to the FDA in the form of an NDA or PLA for marketing approval. The testing and
approval process requires substantial time and effort and there can be no assurance that any approval will be granted on a timely basis, if at all. Additional animal studies or clinical trials may be requested during the FDA review period and may
delay marketing approval. After FDA approval for the initial indications, further clinical trials are necessary to gain approval for the use of the product for additional indications. The FDA may also require post-marketing testing to monitor for
adverse effects, which can involve significant expense.



Among
the conditions for manufacture of clinical drug supplies and for NDA or PLA approval is the requirement that the prospective manufacturers quality control and manufacturing procedures conform to GMP. Prior to approval, manufacturing facilities
are subject to FDA and/or other regulatory agency inspection to ensure compliance with GMP. Manufacturing facilities are subject to periodic regulatory inspection to ensure ongoing compliance.



For marketing outside the U.S., we are also subject to foreign regulatory
requirements governing human clinical trials and marketing approval for drugs. The requirements governing the conduct of clinical trials, product licensing, pricing and reimbursement vary widely from country to country and in some cases are even
more rigorous than in the U.S.



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Scientific and Business Advisors



We have access to a number of academic and industry advisors with expertise in clinical ophthalmology and pharmaceutical
development, marketing and sales. Our advisors meet with our management and key scientific employees on an ad hoc basis to provide advice in their respective areas of expertise and further assist us by periodically reviewing with management our
preclinical, clinical and marketing activities. We plan to make arrangements with other individuals to join as advisors as appropriate. Although we expect to receive guidance from the advisors, all of the advisors are employed on a full-time basis
by other entities, or are primarily engaged in outside business activities, and may have other commitments to, or consulting or advisory contracts with, other entities that may conflict or compete with their obligations to us.



Our advisors are as follows:



|                                |  |                                                                                                                                                    
|------------------------------- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------
|Name                            |  | Position                                                                                                                                           
|Mark Abelson, M.D.              |  | Associate Clinical Professor of Ophthalmology, Department of Ophthalmology, Harvard Medical School                                                 
|Chandler R. Dawson, M.D.        |  | Emeritus Professor, Department of Ophthalmology, University of California, San Francisco                                                           
|Henri-Jean Garchon, M.D., Ph.D. |  | Director, INSERM, France                                                                                                                           
|David G. Hwang, M.D.            |  | Professor of Clinical Ophthalmology, Co-Director, Cornea and Refractive Surgery Service, University of California, San Francisco School of Medicine
|Kazuhide Kawase, M.D.           |  | Associate Professor, Gifu University, Japan                                                                                                        
|Roy Karnovsky                   |  | Advisor and Consultant in Business Development and Marketing                                                                                       
|Eliot Lazar, M.D.               |  | President, El Con Medical Consulting, Buffalo, New York                                                                                            
|Michael Marmor, M. D.           |  | Professor, Department of Ophthalmology, Stanford University School of Medicine                                                                     
|Gary D. Novack, Ph.D.           |  | Founder and President, PharmaLogic Development, Inc.; former Associate Director for Glaucoma Research at Allergan, Inc.                            
|Jon R. Polansky, M. D.          |  | Adjunct Professor of Ophthalmology, University of California, San Francisco                                                                        
|Roger Vogel, M. D.              |  | Medical Director                                                                                                                                   
|Claes Wadelius, M.D., Ph.D.     |  | Professor, Uppsala University, Sweden                                                                                                              



Employees



As of December 31, 2003, we had 22 employees, 17 of which were full time.
None of our employees are covered by a collective bargaining agreement. We believe we have good employee relations. We also utilize independent consultants to provide services in certain areas of our scientific and business operations.



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RISK FACTORS



We Require Immediate Significant Additional Funding to Continue our Operations and If We Are Unable to Complete the Final Closing Related
to a Private Placement Agreement We Have Entered Into, of If We Do Not Receive Additional Funding From Other Sources, We Will Cease Operations and Liquidate our Assets



Our independent auditors included an explanatory paragraph in their audit report referring to our recurring operating losses
and a substantial doubt about our ability to continue as a going concern. On March 26, 2004, we raised gross proceeds of $1.9 million (before transaction fees and expenses) through the initial closing of a private placement of our common stock and
warrants to purchase common stock which we believe will provide us the funds to operate for an additional 60 to 90 days after the initial closing. During this period we will be seeking the stockholder approval necessary to complete the final closing
related to this private placement, which if it occurs will yield additional proceeds of approximately $14.6 million (before transaction fees and expenses). We will be unable to complete the final closing if we are unable to obtain the required
stockholder approval, if we suffer a material adverse change (as such term is defined in the Subscription Agreement related to the private placement) which is not waived by investors in the private placement or if any other condition to
the final closing is not met and not waived by the Subscribers if capable of being waived. Also, pursuant to the terms of the private placement we are generally prohibited from raising additional financing through the issuance of securities during
the period from the initial closing through the earlier to occur of the final closing and June 30, 2004 (subject to extension at our sole discretion), which could significantly harm our ability to continue operations if the final closing does not
occur. If we are unable to complete the final closing or obtain additional funding from private or public equity or debt financings, collaborative or other partnering arrangements, asset sales or other sources, management will be required to cease
all operations and liquidate our remaining assets. If this occurs, our stockholders would likely lose their entire investment in us.



We are seeking longer term additional funding through the final closing of the private placement we entered into in March 2004 and through potential
public or private equity or debt financings, collaborative or other partnering arrangements, asset sales and from other sources. However, our current financial situation may harm our ability to obtain additional funding and could make the terms of
any such funding, if available, significantly less favorable than would otherwise be the case. Our board of directors has the authority to determine the price and terms of any sale of common stock and the rights, preferences and privileges of any
preferred stock or debt or other security that is convertible into or exercisable for the common stock. The terms of any securities issued to future investors may be superior to the rights of our common stockholders and could result in substantial
dilution and could adversely affect the market price for our common stock. If we raise funds through the issuance of debt securities, such debt will likely be secured by a security interest or pledge of all of our assets, will require us to make
principal and interest payments, would likely include the issuance of warrants, and may subject us to restrictive covenants. If we do not obtain such long term financing either through the final closing of the private placement or otherwise, we
would have to cease operations and liquidate our assets. See Item 5. Market for Registrants Common Equity, Related Stockholder Matters and Issuer Purchases of Securities  Recent Sales of Unregistered Securities for a further
description of the March 2004 private placement.



We Will Need Stockholder
Approval to Amend Our Certificate of Incorporation and to Comply with Regulations of The American Stock Exchange in Order to Conduct the Final Closing of the March 2004 Private Placement and If We Do Not Receive such Stockholder Approval, We Will
Not Be Able to Hold the Final Closing, We Will Be Required to Pay Certain Penalties, and We May be Required to Cease Operations and Liquidate our Assets



We do not currently have enough authorized shares of common stock to issue the shares of our common stock and warrants to purchase common stock in the
final closing of the March 2004 private placement. Prior to and as a condition of the final closing of such private placement, the holders of a majority of the shares of our common stock will need to approve an amendment to our certificate of
incorporation to increase the number of shares of common stock we are authorized to issue in an amount sufficient to enable us to issue the common stock and related warrants to be issued in the final closing of the private placement and we will need
to file this amendment with the Secretary of State of the State of



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Delaware. In addition, since our stock is listed on The American Stock Exchange, or AMEX, under applicable AMEX regulations prior to and as a condition of
the final closing of the private placement, the holders of a majority of our common stock present at the meeting by proxy or in person must approve the issuance of the securities to be issued in the final closing since such issuance will constitute
an issuance of 20% or more of our outstanding common stock immediately prior to the initial closing at a price per share below the fair market value of our common stock at the initial closing.



Our stockholders will incur substantial dilution if the final closing of the
March 2004 private placement occurs, and this might negatively affect our chances of receiving stockholder approval. However, if we do not receive the requisite stockholder approval within the required period, we will be required to pay certain cash
penalties to the investors in the private placement and even if we subsequently receive stockholder approval the investors in the private placement can refuse to invest in the final closing, either of which would significantly harm our business and
our financial condition. In addition, if we are unable to complete the final closing, we will likely not have sufficient funds to continue our business, and we will have to attempt to conduct another round of financing, if available, or go out of
business, in which case our stockholders will likely be significantly diluted or lose their entire investment. Furthermore, in between the initial closing and final closing of the March 2004 private placement, provisions in the subscription
agreements for that private placement impose significant restrictions on our ability to raise capital through the sale of additional securities other than those contemplated by the private placement.



Even if the Final Closing of the Private Placement Occurs, or We Are Able to Secure
Alternative Long Term Financing in the Event the Final Closing Does Not Occur, the Proceeds From Such Financings Will Not Fund Our Business Indefinitely. We Will Eventually Need to Seek Additional Funding or Partnering Arrangements that Could Be
Dilutive to Our Stockholders and Could Negatively Affect Us and Our Stock Price.



Assuming we are able to raise additional funding to continue our operations beyond the next 60 to 90 days, either through the final closing of the private placement or an alternative financing arrangement if the final
closing does not occur, we only expect the proceeds to us expected from the private placement to enable us to continue our operations as currently planned until approximately the third quarter of 2005. At that point, or earlier if circumstances
change from our current expectations, we will require additional funding. The terms of any securities issued to future investors may be superior to the rights of our then current stockholders, and could result in substantial dilution and could
adversely affect the market price for our common stock. If we raise funds through the issuance of debt securities, such debt will likely be secured by a security interest or pledge of all of our assets, will require us to make principal and interest
payments, would likely include the issuance of warrants, and may subject us to restrictive covenants. If we do not obtain such additional financing when required, we would likely have to cease operations and liquidate our assets.



In addition, we expect to enter into partnering and collaborative
arrangements in the future as part of our business plan, regardless of whether we require additional funding to continue our operations. Such arrangements could include the licensing or sale of certain assets or the issuance of securities, which may
adversely affect the market price of our Common Stock. It is difficult to know our future capital requirements precisely and such requirements depend upon many factors, including:



| |  | the progress of preclinical and clinical testing;
| | - | -------------------------------------------------



| |  | the progress of our research and development programs;
| | - | ------------------------------------------------------



| |  | our ability to establish additional corporate partnerships to develop, manufacture and market our potential products;
| | - | ---------------------------------------------------------------------------------------------------------------------



| |  | the cost of maintaining or expanding a marketing organization for OcuGene and the related promotional activities;
| | - | -----------------------------------------------------------------------------------------------------------------



| |  | changes in, or termination of, our existing collaboration or licensing arrangements;
| | - | ------------------------------------------------------------------------------------



| |  | whether we manufacture and market any of our other products ourselves;
| | - | ----------------------------------------------------------------------



| |  | the time and cost involved in obtaining regulatory approvals;
| | - | -------------------------------------------------------------



| |  | the cost of filing, prosecuting, defending and enforcing patent claims and other intellectual property rights;
| | - | --------------------------------------------------------------------------------------------------------------



| |  | competing technological and market developments; and
| | - | ----------------------------------------------------



| |  | the purchase of additional capital equipment.
| | - | ---------------------------------------------



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If We Do Not Receive Additional Funding When Needed to Continue Our Operations, Whether Before or After the Final
Closing of the March 2004 Private Placement, We Will Likely Cease Operations and Liquidate Our Assets, Which are Secured by Notes Payable to Our Chief Executive Officer



In the event that we are unable to secure additional funding when required to continue our operations, we will likely be
forced to wind down our operations, either through liquidation, voluntary or involuntary bankruptcy or a sale of our assets, regardless of whether such event occurred before or after the final closing of the March 2004 private placement. Our chief
executive officer has outstanding loans to us in an aggregate principal amount of $503,000, $400,000 of which is secured by a lien on substantially all of our assets including our intellectual property. The notes issued by us in connection with
these loans are due on the earlier to occur of March 31, 2007 and 30 days subsequent to the successful completion of a pivotal Phase III clinical trial with ISV 401. In the event that we wind down operations, whether voluntarily or involuntarily,
while these secured loans are outstanding, this security interest enables our chief executive officer to control the disposition of these assets. If we are unable to repay the amounts due under the secured notes when due, our chief executive officer
could cause us to enter into involuntary liquidation proceedings in the event we default on our obligations. If we wind down our operations for any reason, it is likely that our stockholders will lose their entire investment in us.



Our Management has Undertaken a Number of Measures to Reduce our Operating Expenses, but
These Measures Will Not Alone be Sufficient to Enable us To Continue Operations Beyond the Middle of June 2004 and May Have Other Negative Consequences



Our management has implemented plans designed to reduce our cash requirements through reductions in operating expenditures. The actions we have
taken include laying-off approximately 42% of our employees, voluntary salary reductions by our senior management team, ceasing work on all non-critical external projects, extending payment terms on our trade payables, working with our landlord to
restructure our lease obligations, and other cost containment measures. Although it is not possible to anticipate all potential effects the implementation of these expense control measures will have on us or our development, these activities have
and could continue to delay the initiation of Phase 3 clinical trials on ISV-401 and have and could continue to impact our ability to promote OcuGene. The extent and ramifications of these delays will be dependent upon our ability to raise
additional financing, the timing of the receipt of financing and the amount of such financing, if any. However, even with these expense reductions, the funds from the initial closing of the private placement, our current cash on hand, anticipated
cash flow from operations and current cash commitments to us are only sufficient to fund our operations through approximately the middle of June 2004. If we are unable to complete the final closing of the private placement or another financing
transaction, collaborative arrangement or asset sale prior to that time, we will cease operations and liquidate our assets. In addition, there is no assurance that these expense reduction efforts will enable us to continue operations or that if we
do survive we have not significantly harmed our business or prospects.



The Initial Closing of the March 2004 Private Placement Triggered Anti-Dilution Adjustments Under the Terms of Certain Outstanding Securities Convertible into or Exercisable for Shares of Our Common Stock and Additional Anti-Dilution
Adjustments Could Be Triggered by the Final Closing of the Private Placement, Which Would Be Dilutive to Our Stockholders.



Immediately prior to the initial closing of the March 2004 private placement there was an aggregate of approximately $18,000 in principal amount and
accrued interest outstanding under our convertible debentures held by HEM. Pursuant to anti-dilution adjustments contained in the debentures, following the initial closing of the private placement these debentures are now convertible into
unrestricted shares of our common stock at a conversion price that is the lower of $0.35394 or the average of the three lowest closing per share bid prices for our common stock during the 40 trading days prior to conversion. If these debentures
remain outstanding on the final closing of the March 2004 private placement, the conversion price of the debentures will be further adjusted downward on such closing date if the market price of our common stock on such closing date is below $0.50,
the per share sale price of our common stock that would be sold at such final closing. Pursuant to the terms of the debentures, if the anti-dilution adjustment is triggered at the final closing, the new conversion price of the debentures will be
calculated by multiplying the then current conversion price by a fraction, the numerator of which will be the number of shares of our common stock (excluding treasury shares, if any) outstanding on the date of the final closing plus the number of
shares which the aggregate price paid for the shares issued at such closing (assuming the



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exercise of warrants issued at such closing) would have purchased at the then current market price of the common stock, and the denominator of which will be
the number of shares of our common stock (excluding treasury shares, if any) outstanding on the date of the final closing plus the number of additional shares of common stock to be issued in such closing (including any shares issuable upon the
exercise of warrants issued in such closing). The amount of this adjustment will be dependent upon the market price of our common stock at the time of the final closing of the March 2004 private placement. Such anti-dilution adjustments would be
dilutive to our then current stockholders.



Immediately prior
to the initial closing of the March 2004 private placement, warrants we issued to Xmark were exercisable for 250,000 shares of our Common Stock at a price of $0.58 per share. Pursuant to anti-dilution provisions contained in these warrants,
following the initial closing of the private placement these warrants became exercisable for 254,386 shares of our common stock at a price of $0.57 per share. If any of these warrants are outstanding on the date of the final closing, the exercise
price of the warrants will be adjusted downwards at such closing as follows:



Adjusted Warrant Price = (A x B) + D

A+C



where:

|A | =     the number of shares of common stock outstanding immediately preceding the final closing
|- | ----------------------------------------------------------------------------------------------



|B | =     the exercise price of the warrant in effect immediately preceding the final closing
|- | -----------------------------------------------------------------------------------------



|C | =     the number of additional shares of common stock outstanding as a result of the final closing
|- | --------------------------------------------------------------------------------------------------



|D | =     the aggregate consideration received by us upon the final closing
|- | -----------------------------------------------------------------------



Additionally, upon each adjustment in the exercise price of the Xmark warrants, the number of shares purchasable under these
warrants is adjusted, to the nearest whole share, to the product obtained by multiplying the number of shares purchasable immediately prior to such adjustment by a fraction, the numerator of which is the exercise price immediately prior to such
adjustment, and the denominator of which is the exercise price immediately thereafter.



It Is Difficult to Evaluate Our Business Because We Are in an Early Stage of Development and Our Technology Is Untested



We are in an early stage of developing our business. We have only received an insignificant amount of royalties from the sale of one of our products, an
over-the-counter dry eye treatment, and in 2002 we began to receive a small amount of revenues from the sale of our OcuGene glaucoma genetic test. Before regulatory authorities grant us marketing approval for additional products, we need to conduct
significant additional research and development and preclinical and clinical testing. All of our products are subject to risks that are inherent to products based upon new technologies. These risks include the risks that our products:



| |  | are found to be unsafe or ineffective;
| | - | --------------------------------------



| |  | fail to receive necessary marketing clearance from regulatory authorities;
| | - | --------------------------------------------------------------------------



| |  | even if safe and effective, are too difficult or expensive to manufacture or market;
| | - | ------------------------------------------------------------------------------------



| |  | are unmarketable due to the proprietary rights of third parties; or
| | - | -------------------------------------------------------------------



| |  | are not able to compete with superior, equivalent or more cost-effective products offered by competitors.
| | - | ---------------------------------------------------------------------------------------------------------



Therefore, our research and development activities may not result in any commercially viable products.



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Clinical Trials Are Very Expensive, Time-Consuming and Difficult to Design and Implement



Human clinical trials are very expensive and difficult to design and
implement, in part because they are subject to rigorous regulatory requirements. The clinical trial process is also time consuming. We estimate that clinical trials of our product candidates will take at least several years to complete once
initiated. Furthermore, failure can occur at any stage of the trials, and we could encounter problems that cause us to abandon or repeat clinical trials, further delaying or preventing the completion of such trials. The commencement and completion
of clinical trials may be delayed by several factors, including:



| |  | unforeseen safety issues;
| | - | -------------------------



| |  | determination of dosing issues;
| | - | -------------------------------



| |  | lack of effectiveness during clinical trials;
| | - | ---------------------------------------------



| |  | slower than expected rates of patient recruitment;
| | - | --------------------------------------------------



| |  | inability to monitor patients adequately during or after treatment; and
| | - | -----------------------------------------------------------------------



| |  | inability or unwillingness of medical investigators to follow our clinical protocols.
| | - | -------------------------------------------------------------------------------------



In addition, we or the FDA may suspend our clinical trials at any time if it appears that we are exposing participants to
unacceptable health risks or if the FDA finds deficiencies in our submissions or the conduct of these trials.



The Results of Our Clinical Trials May Not Support Our Product Candidate Claims



Even if our clinical trials are completed as planned, we cannot be certain that their results will support our product candidate claims. Success in
pre-clinical testing and early clinical trials does not ensure that later clinical trials will be successful, and we cannot be sure that the results of later clinical trials will replicate the results of prior clinical trials and pre-clinical
testing. The clinical trial process may fail to demonstrate that our product candidates are safe for humans and effective for indicated uses. This failure would cause us to abandon a product candidate and may delay development of other product
candidates. Any delay in, or termination of, our clinical trials will delay the filing of our NDAs with the FDA and, ultimately, our ability to commercialize our product candidates and generate product revenues. In addition, our clinical trials
involve a small patient population. Because of the small sample size, the results of these clinical trials may not be indicative of future results.



Physicians and Patients May Not Accept and Use Our Drugs



Even if the FDA approves our product candidates, physicians and patients may not accept and use them. Acceptance and use of our product will depend upon a
number of factors including:



| |  | perceptions by members of the health care community, including physicians, about the safety and effectiveness of our drugs;
| | - | ---------------------------------------------------------------------------------------------------------------------------



| |  | cost-effectiveness of our product relative to competing products;
| | - | -----------------------------------------------------------------



| |  | availability of reimbursement for our products from government or other healthcare payers; and
| | - | ----------------------------------------------------------------------------------------------



| |  | effectiveness of marketing and distribution efforts by us and our licensees and distributors, if any.
| | - | -----------------------------------------------------------------------------------------------------



Because we expect sales of our current product candidates, if approved, to generate substantially all of our product
revenues for the foreseeable future, the failure of any of these drugs to find market acceptance would harm our business and could require us to seek additional financing.



If We Cannot Compete Successfully for Market Share Against Other Drug Companies, We May Not Achieve Sufficient Product Revenues and Our
Business Will Suffer



The market for our product
candidates is characterized by intense competition and rapid technological advances. If our product candidates receive FDA approval, they will compete with a number of existing and future drugs and therapies developed, manufactured and marketed by
others. Existing or future competing products may provide greater therapeutic convenience or clinical or other benefits for a specific indication than our products, or may offer comparable performance at a lower cost. If our products fail to capture
and maintain market share, we may not achieve sufficient product revenues and our business will suffer.





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We will compete against fully integrated pharmaceutical companies and smaller companies that are
collaborating with larger pharmaceutical companies, academic institutions, government agencies and other public and private research organizations. Many of these competitors have compounds competitive with ours already approved or in development. In
addition, many of these competitors, either alone or together with their collaborative partners, operate larger research and development programs and have substantially greater financial resources than we do, as well as significantly greater
experience in:



| |  | developing drugs;
| | - | -----------------



| |  | undertaking pre-clinical testing and human clinical trials;
| | - | -----------------------------------------------------------



| |  | obtaining FDA and other regulatory approvals of drugs;
| | - | ------------------------------------------------------



| |  | formulating and manufacturing drugs;
| | - | ------------------------------------



| |  | launching, marketing and selling drugs; and
| | - | -------------------------------------------



| |  | attracting qualified personnel, parties for acquisitions, joint ventures or other collaborations.
| | - | -------------------------------------------------------------------------------------------------



We May Not Successfully Manage Our Growth



Our success will depend upon the expansion of our operations and the effective management of our growth, which will place a significant strain on our
management and on our administrative, operational and financial resources. To manage this growth, we must expand our facilities, augment our operational, financial and management systems and hire and train additional qualified personnel. If we are
unable to manage our growth effectively, our business would be harmed.



We Are Dependent Upon Key Employees and We May Not Be Able to Retain or Attract Key Employees, and Our Ability to Attract and Retain Key Employees is Likely to be Harmed by Our Current Financial Situation



We are highly dependent on Dr. Chandrasekaran, who is our chief
executive officer, president and chief financial officer, and on other principal members of our scientific and management team. The loss of services from any of these key personnel might significantly delay or prevent the achievement of planned
development objectives. Furthermore, a critical factor to our success will be recruiting and retaining qualified personnel. Competition for skilled individuals in the biotechnology business is highly intense, and we may not be able to continue to
attract and retain personnel necessary for the development of our business. Our ability to attract and retain such individuals is likely to be significantly reduced by our current financial situation and our past reductions in force. For example, we
have recently laid-off approximately 42% of our employees and our senior management has agreed to accept reduced salaries. These measures and other cost reduction measures we have undertaken make it more likely that such individuals will seek other
employment opportunities and may leave our company permanently. The loss of key personnel or the failure to recruit additional personnel or to develop needed expertise could harm our business.



Questions Concerning Our Financial Condition May Cause Customers and Current and Potential
Partners to Reduce or Not Conduct Business with Us



Due to
our present financial condition and concerns regarding our ability to continue operations, customers and current and potential partners may decide not to conduct business with us, may reduce or terminate the business they conduct with us, or may
conduct business with us on terms that are less favorable than those customarily offered by them. In that event, our sales would likely decrease, our product development efforts would suffer and our business will be significantly harmed.



We Have a History of Operating Losses and We Expect to Continue to Have Losses in the
Future



We have incurred significant operating losses
since our inception in 1986 and have pursued numerous drug development candidates that did not prove to have commercial potential. As of December 31, 2003, our accumulated deficit was approximately $115.7 million. We expect to incur net losses for
the foreseeable future or until we are able to achieve significant royalties or other revenues from sales of our products. In addition, we recognize revenue when all services have been performed and collectibility is reasonably assured, accordingly,
revenue for the sales of OcuGene may be recognized in a later period than the associated recognition of costs of the services provided, especially during the initial launch of the product. In addition, due to this delay in revenue recognition, our
revenues recognized in any given period may not be indicative of our then current viability and market acceptance of our OcuGene product.





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Attaining significant revenue or profitability depends upon our ability, alone or with third parties, to
successfully develop our potential products, conduct clinical trials, obtain required regulatory approvals and successfully manufacture and market our products. We may not ever achieve or be able to maintain significant revenue or profitability.



We Rely on Third Parties to Develop, Market and Sell Our Products, We May
Not Be Able to Continue or Enter into Third Party Arrangements, and these Third Parties Efforts May Not Be Successful



Following the termination of our ISV-900 agreement with Pharmacia in December 2000, we began to develop a marketing organization focused on the launch of
our OcuGene glaucoma genetic test. We do not plan on establishing a dedicated sales force or a marketing organization for our other product candidates and primarily use external marketing and sales resources even for OcuGene. We also rely on third
parties for clinical testing or product development. In addition, in May 2001, Pharmacia terminated the licensing agreement we had entered into with them in January 1999, that granted Pharmacia an exclusive worldwide license for ISV-205 for the
treatment of glaucoma. We now must enter into another third party collaboration agreement for the development, marketing and sale of our ISV-205 product or develop, market and sell the product ourselves. There can be no assurance that we will be
successful in finding a new corporate partner for our ISV-205 program or that any collaboration will be successful, either of which could significantly harm our business. In addition, we have no experience in marketing and selling products and we
cannot assure you that we would be successful in marketing ISV-205 ourselves. If we are to successfully develop and commercialize our product candidates, including ISV-205, we will be required to enter into arrangements with one or more third
parties that will:



| |  | provide for Phase 2 and/or Phase 3 clinical testing;
| | - | ----------------------------------------------------



| |  | obtain or assist us in other activities associated with obtaining regulatory approvals for our product candidates; and
| | - | ----------------------------------------------------------------------------------------------------------------------



| |  | market and sell our products, if they are approved.
| | - | ---------------------------------------------------



In December 2003, we completed the sale of our drug candidate ISV-403 for the treatment of ocular infections to Bausch & Lomb Incorporated. Bausch
& Lomb has assumed all future ISV-403 development and commercialization expenses and, following a transfer period, will be responsible for all development activities, with our assistance, as appropriate. The Bausch & Lomb Purchase Agreement
and License Agreement grants Bausch & Lomb rights to develop and market ISV-403, subject to payment of royalties, in all geographies except Japan (which were retained by SSP, in connection with a separate license agreement between us and SSP),
with such rights being shared with SSP in Asia (except Japan) and exclusive elsewhere. This sale resulted in the termination of the August 2002 license agreement we entered into with Bausch & Lomb related to ISV-403. Our ability to generate
royalties from this agreement will be dependent upon Bausch & Lombs ability to complete the development of ISV-403, obtain regulatory approval for the product and successfully market it. In addition, under the Bausch & Lomb Purchase
Agreement, we also have certain potential indemnification obligations to Bausch & Lomb in connection with the Asset Sale which, if triggered, could significantly harm our business and our financial position.



We are marketing and selling our OcuGene glaucoma genetic test mainly using
external marketing and sales resources that include:



| |  | marketing consultants;
| | - | ----------------------



| |  | a network of key ophthalmic clinicians; and
| | - | -------------------------------------------



| |  | other resources with ophthalmic expertise.
| | - | ------------------------------------------



We may not be able to enter into arrangements with third parties with ophthalmic or diagnostic industry experience on acceptable terms or at all. If we
are not successful in concluding such arrangements on acceptable terms, or at all, we may be required to establish our own sales force and significantly expand our marketing organization, despite the fact that we have no experience in sales,
marketing or distribution. Even if we do enter into collaborative relationships, as we have recently experienced with Pharmacia, these relationships can be terminated forcing us to seek alternatives. We may not be able to build a marketing staff or
sales force and our sales and marketing efforts may not be cost-effective or successful.



In addition, we currently contract with a third party to assemble the sample collection kits used in our OcuGene glaucoma genetic test. If our assembler should encounter significant delays or we have



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difficulty maintaining our existing relationship, or in establishing a new one, our sales of this product could be adversely affected.



Our Strategy for Research, Development and Commercialization of Our Products Requires Us
to Enter Into Various Arrangements With Corporate and Academic Collaborators, Licensors, Licensees and Others. Furthermore, We Are Dependent on the Diligent Efforts and Subsequent Success of These Outside Parties in Performing Their
Responsibilities.



Because of our reliance on third
parties for the development, marketing and sale of our products, any revenues that we receive will be dependent on the efforts of these third parties, such as our corporate collaborators. These partners may terminate their relationships with us and
may not diligently or successfully market our products. In addition, marketing consultants and contract sales organizations, such as those deployed by us currently or in the future for OcuGene, may market products that compete with our products and
we must rely on their efforts and ability to effectively market and sell our products. We may not be able to conclude arrangements with other companies to support the commercialization of our products on acceptable terms, or at all. Moreover, our
current financial condition may make us a less attractive partner to potential collaborators. In addition, our collaborators may take the position that they are free to compete using our technology without compensating or entering into agreements
with us. Furthermore, our collaborators may pursue alternative technologies or develop alternative products either on their own or in collaboration with others, including our competitors, as a means for developing treatments for the diseases or
disorders targeted by these collaborative programs.



Our Business Depends
Upon Our Proprietary Rights, and We May Not Be Able to Adequately Protect, Enforce or Secure Our Intellectual Property Rights



Our future success will depend in large part on our ability to obtain patents, protect trade secrets, obtain and maintain rights to technology developed
by others, and operate without infringing upon the proprietary rights of others. A substantial number of patents in the field of ophthalmology and genetics have been issued to pharmaceutical, biotechnology and biopharmaceutical companies. Moreover,
competitors may have filed patent applications, may have been issued patents or may obtain additional patents and proprietary rights relating to products or processes competitive with ours. Our patent applications may not be approved. We may not be
able to develop additional proprietary products that are patentable. Even if we receive patent issuances, those issued patents may not be able to provide us with adequate protection for our inventions or may be challenged by others. Furthermore, the
patents of others may impair our ability to commercialize our products. The patent positions of firms in the pharmaceutical and genetic industries generally are highly uncertain, involve complex legal and factual questions, and have recently been
the subject of much litigation. Neither the United States Patent and Trademark Office nor the courts has developed, formulated, or presented a consistent policy regarding the breadth of claims allowed or the degree of protection afforded under
pharmaceutical and genetic patents. Despite our efforts to protect our proprietary rights, others may independently develop similar products, duplicate any of our products or design around any of our patents. In addition, third parties from which we
have licensed or otherwise obtained technology may attempt to terminate or scale back our rights.



A number of pharmaceutical and biotechnology companies and research and academic institutions have developed technologies, filed patent applications or
received patents on various technologies that may be related to our business. Some of these technologies, applications or patents may conflict with our technologies or patent applications. Such conflicts could limit the scope of the patents, if any,
we may be able to obtain or result in the denial of our patent applications or block our rights to exploit our technology. In addition, if the United States Patent and Trademark Office or foreign patent agencies have issued or issue patents that
cover our activities to other companies, we may not be able to obtain licenses to these patents at all, or at a reasonable cost, or be able to develop or obtain alternative technology. If we do not obtain such licenses, we could encounter delays in
or be precluded altogether from introducing products to the market. For example, we are aware that the European Patent Office has indicated that it intends to grant a patent to Pfizer covering the use of azithromycin once a day in a topical
formulation to treat bacterial infections in the eye. We may conclude that we require a license under this patent to develop or sell ISV-401 in Europe, which may not be available on reasonable commercial terms if at all.



We may need to litigate in order to defend against or assert claims of
infringement, to enforce patents issued to us or to protect trade secrets or know-how owned or licensed by us. Litigation could result



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in substantial cost to and diversion of effort by us, which may harm our business. We have also agreed to indemnify our licensees against infringement claims
by third parties related to our technology, which could result in additional litigation costs and liability for us. In addition, our efforts to protect or defend our proprietary rights may not be successful or, even if successful, may result in
substantial cost to us.



We also depend upon unpatented trade
secrets to maintain our competitive position. Others may independently develop substantially equivalent proprietary information and techniques or otherwise gain access to our trade secrets. Our trade secrets may also be disclosed, and we may not be
able to effectively protect our rights to unpatented trade secrets. To the extent that we or our consultants or research collaborators use intellectual property owned by others, disputes also may arise as to the rights in related or resulting
know-how and inventions.



Our Current Financial Situation May Impede Our
Ability to Adequately Protect or Enforce Our Legal Rights Under Agreements and to Our Intellectual Property



We currently do not have sufficient funds, anticipated cash flow from operations and current cash commitments to us to continue our operations
beyond approximately the middle of June 2004. Our current financial situation may impede our ability to enforce our legal rights under various agreements we are currently a party to or may become a party to due to our inability to incur the costs
associated with such enforcement. Similarly, our lack of financial resources makes it more difficult for us to enforce our intellectual property rights, through the filing or maintenance of patents, taking legal action against those that may
infringe on our proprietary rights, defending infringement claims against us, or otherwise. Our inability to adequately protect our legal and intellectual property rights may make us more vulnerable to infringement and could harm our business.



If We Infringe the Rights of Third Parties We Could Be Prevented From
Selling Products, Forced to Pay Damages, and Defend Against Litigation



If our products, methods, processes and other technologies infringe the proprietary rights of other parties, we could incur substantial costs and we may have to:



| |  | obtain licenses, which may not be available on commercially reasonable terms, if at all;
| | - | ----------------------------------------------------------------------------------------



| |  | redesign our products or processes to avoid infringement;
| | - | ---------------------------------------------------------



| |  | stop using the subject matter claimed in the patents held by others;
| | - | --------------------------------------------------------------------



| |  | pay damages; or
| | - | ---------------



| |  | defend litigation or administrative proceedings which may be costly whether we win or lose, and which could result in a substantial diversion of our valuable management resources.
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



We Have No Experience in Commercial Manufacturing and Need to
Establish Manufacturing Relationships with Third Parties, and If Contract Manufacturing Is Not Available to Us or Does Not Satisfy Regulatory Requirements, We Will Have to Establish Our Own Regulatory Compliant Manufacturing Capability and May Not
Have the Financial Resources to Do So



We have no
experience manufacturing products for Phase 3 and commercial purposes. We have a pilot facility licensed by the State of California to manufacture a number of our products for Phase 1 and Phase 2 clinical trials but not for late stage clinical
trials or commercial purposes. Any delays or difficulties that we may encounter in establishing and maintaining a relationship with qualified manufacturers to produce, package and distribute our finished products may harm our clinical trials,
regulatory filings, market introduction and subsequent sales of our products.



We currently contract with a third party to assemble the sample collection kits used in our OcuGene glaucoma genetic test. If our assembler should encounter significant delays or we have difficulty maintaining our
existing relationship, or in establishing a new one, our sales of this product could be adversely affected.



Contract manufacturers must adhere to Good Manufacturing Practices regulations that are strictly enforced by the FDA on an ongoing basis through the
FDAs facilities inspection program. Contract manufacturing facilities must pass a pre-approval plant inspection before the FDA will approve a new drug application. Some of the material manufacturing changes that occur after approval are also
subject to FDA



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review and clearance or approval. The FDA or other regulatory agencies may not approve the process or the facilities by which any of our products may be
manufactured. Our dependence on third parties to manufacture our products may harm our ability to develop and deliver products on a timely and competitive basis. Should we be required to manufacture products ourselves, we:



| |  | will be required to expend significant amounts of capital to install a manufacturing capability;
| | - | ------------------------------------------------------------------------------------------------



| |  | will be subject to the regulatory requirements described above;
| | - | ---------------------------------------------------------------



| |  | will be subject to similar risks regarding delays or difficulties encountered in manufacturing any such products; and
| | - | ---------------------------------------------------------------------------------------------------------------------



| |  | will require substantial additional capital than we otherwise may require.
| | - | --------------------------------------------------------------------------



Therefore, we may not be able to manufacture any products successfully or in a cost-effective manner.



We Have No Experience in Performing the Analytical Procedures Related to Genetic Testing
and Have Established an Exclusive Commercial Agreement with a Third Party to Perform These Procedures For Our OcuGene Glaucoma Genetic Test. If We Are Unable to Maintain this Arrangement, and Are Unable to Establish New Arrangements with Third
Parties, We Will Have to Establish Our Own Regulatory Compliant Analytical Process for Genetic Testing and May Not Have the Financial Resources to Do So



We have no experience in the analytical procedures related to genetic testing. We have entered into an agreement with Quest Diagnostics Incorporated under
which Quest exclusively performs OcuGene genetic analytical procedures at a commercial scale in the United States. Accordingly, we are reliant on Quest for all of our OcuGene analytical procedures. If we are unable to maintain this arrangement, we
would have to contract with another clinical laboratory or would have to establish our own facilities. We cannot assure you that we will be able to contract with another laboratory to perform these services on a commercially reasonable basis, or at
all.



Clinical laboratories must adhere to Good Laboratory
Practice regulations that are strictly enforced by the FDA on an ongoing basis through the FDAs facilities inspection program. Should we be required to perform the analytical procedures for genetic testing ourselves, we:



| |  | will be required to expend significant amounts of capital to install an analytical capability;
| | - | ----------------------------------------------------------------------------------------------



| |  | will be subject to the regulatory requirements described above; and
| | - | -------------------------------------------------------------------



| |  | will require substantial additional capital than we otherwise may require.
| | - | --------------------------------------------------------------------------



We cannot assure you we will be able to successfully enter into another genetic testing arrangement or perform these analytical procedures ourselves on a
cost-efficient basis, or at all.



We Rely on a Sole Source for Some of the
Raw Materials in Our Products, and the Raw Materials We Need May Not be Available to Us



SSP is the sole source for the active drug incorporated into the ISV-403 product candidate we sold to Bausch & Lomb for further development and commercialization. SSP has registered the compound with the FDA and
is subject to the FDAs review and oversight. If SSP is unable to obtain and maintain FDA approval for their production of the drug or is otherwise unable to supply Bausch & Lomb with sufficient quantities of the drug, Bausch &
Lombs ability to continue with the development, and potentially the commercial sale if the product is approved, would be interrupted or impeded, our royalties from commercial sales of the ISV-403 product could be delayed or reduced and our
business could be harmed.



We have entered into a material
supply agreement for azithromycin, the active drug incorporated into our ISV-401 product candidate. The supplier has registered with the FDA and is subject to the FDAs review and oversight. If the FDA were to identify issues in the production
of the drug that the supplier was unable to quickly resolve, or other issues were to arise that impact production, our ability to continue with the development, and potentially the commercial sale if the product is approved, would be interrupted and
would harm our business. Additional suppliers for this drug exist, but qualification of an alternative source could be time consuming, expensive and could result in a delay that could harm our business and there is no guarantee that these additional
suppliers can supply sufficient quantities at a reasonable price, or at all.



In addition, certain of the raw materials we use in formulating our DuraSite drug delivery system, and other components of our product candidates, are available from only one source. Any significant



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interruption in the supply of these raw materials could delay our clinical trials, product development or product sales and could harm our business.



Our Products Are Subject to Government Regulations and Approval Which May
Delay or Prevent the Marketing of Potential Products and Impose Costly Procedures Upon Our Activities



The FDA and comparable agencies in state and local jurisdictions and in foreign countries impose substantial requirements upon preclinical and clinical
testing, manufacturing and marketing of pharmaceutical products. Lengthy and detailed preclinical and clinical testing, validation of manufacturing and quality control processes, and other costly and time-consuming procedures are required.
Satisfaction of these requirements typically takes several years and the time needed to satisfy them may vary substantially, based on the type, complexity and novelty of the pharmaceutical product. The effect of government regulation may be to delay
or to prevent marketing of potential products for a considerable period of time and to impose costly procedures upon our activities. The FDA or any other regulatory agency may not grant approval for any products we develop on a timely basis, or at
all. Success in preclinical or early stage clinical trials does not assure success in later stage clinical trials. Data obtained from preclinical and clinical activities are susceptible to varying interpretations that could delay, limit or prevent
regulatory approval. If regulatory approval of a product is granted, such approval may impose limitations on the indicated uses for which a product may be marketed. Further, even after we have obtained regulatory approval, later discovery of
previously unknown problems with a product may result in restrictions on the product, including withdrawal of the product from the market. Moreover, the FDA has recently reduced previous restrictions on the marketing, sale and prescription of
products for indications other than those specifically approved by the FDA. Accordingly, even if we receive FDA approval of a product for certain indicated uses, our competitors, including our collaborators, could market products for such
indications even if such products have not been specifically approved for such indications. Additionally, the FDA recently issued an advisory that microarrays used for diagnostic and prognostic testing may need regulatory approval. The need for
regulatory approval of multiple gene analysis is uncertain at this time. Delay in obtaining or failure to obtain regulatory approvals would make it difficult or impossible to market our products and would harm our business.



The FDAs policies may change and additional government regulations may
be promulgated which could prevent or delay regulatory approval of our potential products. Moreover, increased attention to the containment of health care costs in the United States could result in new government regulations that could harm our
business. Adverse governmental regulation might arise from future legislative or administrative action, either in the United States or abroad. See Uncertainties Regarding Healthcare Reform and Third-Party Reimbursement may Impair Our
Ability to Raise Capital, Form Collaborations and Sell Our Products.



We Compete in Highly Competitive Markets and Our Competitors Financial, Technical, Marketing, Manufacturing and Human Resources May Surpass Ours and Limit Our Ability to Develop and/or Market Our Products and Technologies



Our success depends upon developing and maintaining a
competitive advantage in the development of products and technologies in our areas of focus. We have many competitors in the United States and abroad, including pharmaceutical, biotechnology and other companies with varying resources and degrees of
concentration in the ophthalmic market. Our competitors may have existing products or products under development which may be technically superior to ours or which may be less costly or more acceptable to the market. Competition from these companies
is intense and is expected to increase as new products enter the market and new technologies become available. Many of our competitors have substantially greater financial, technical, marketing, manufacturing and human resources than we do,
particularly in light of our current financial condition. In addition, they may succeed in developing technologies and products that are more effective, safer, less expensive or otherwise more commercially acceptable than any that we have or will
develop. Our competitors may obtain cost advantages, patent protection or other intellectual property rights that would block or limit our ability to develop our potential products. Our competitors may also obtain regulatory approval for
commercialization of their products more effectively or rapidly than we will. If we decide to manufacture and market our products by ourselves, we will be competing in areas in which we have limited or no experience such as manufacturing efficiency
and marketing capabilities. See  We Have No Experience in Commercial Manufacturing and Need to Establish Manufacturing Relationships with Third Parties, and if Contract Manufacturing is Not Available



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to Us or Does Not Satisfy Regulatory Requirements, We Will Have to Establish Our Own Regulatory Compliant Manufacturing Capability.



If We Engage in Acquisitions, We Will Incur a Variety of Costs, and the Anticipated
Benefits of the Acquisition May Never be Realized



We may
pursue acquisitions of companies, product lines, technologies or businesses that our management believes are complementary or otherwise beneficial to us. Any of these acquisitions could have negative effects on our business. Future acquisitions may
result in substantial dilution to our stockholders, the incurrence of additional debt and amortization expenses related to goodwill, research and development and other intangible assets. Any of these results could harm our financial condition. In
addition, acquisitions would involve several risks for us, including:



| |  | assimilating employees, operations, technologies and products from the acquired companies with our existing employees, operation, technologies and products;
| | - | ------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  | diverting our managements attention from day-to-day operation of our business;
| | - | -------------------------------------------------------------------------------



| |  | entering markets in which we have no or limited direct experience; and
| | - | ----------------------------------------------------------------------



| |  | potentially losing key employees from the acquired companies.
| | - | -------------------------------------------------------------



Our Insurance Coverage May Not Adequately Cover Our Potential Product Liability Exposure



We are exposed to potential product liability risks inherent in the development, testing, manufacturing, marketing and sale
of human therapeutic products. Product liability insurance for the pharmaceutical industry is extremely expensive. Our present product liability insurance coverage may not be adequate to cover all potential claims we may encounter. In addition, our
existing coverage will not be adequate as we further develop, manufacture and market our products, and we may not be able to obtain or afford adequate insurance coverage against potential claims in sufficient amounts or at a reasonable cost.



Uncertainties Regarding Healthcare Reform and Third-Party Reimbursement May
Impair Our Ability to Raise Capital, Form Collaborations and Sell Our Products



The continuing efforts of governmental and third-party payers to contain or reduce the costs of healthcare through various means may harm our business. For example, in some foreign markets the pricing or profitability
of health care products is subject to government control. In the United States, there have been, and we expect there will continue to be, a number of federal and state proposals to implement similar government control. The implementation or even the
announcement of any of these legislative or regulatory proposals or reforms could harm our business by impeding our ability to achieve profitability, raise capital or form collaborations.



In addition, the availability of reimbursement from third-party payers determines, in large part, the demand for healthcare
products in the United States and elsewhere. Examples of such third-party payers are government and private insurance plans. Significant uncertainty exists as to the reimbursement status of newly approved healthcare products, and third-party payers
are increasingly challenging the prices charged for medical products and services. If we succeed in bringing one or more products to the market, reimbursement from third party payers may not be available or may not be sufficient to allow us to sell
our products on a competitive or profitable basis.



Our Use of Hazardous
Materials May Pose Environmental Risks and Liabilities Which May Cause Us to Incur Significant Costs



Our research, development and manufacturing processes involve the controlled use of small amounts of radioactive and other hazardous materials. We cannot
completely eliminate the risk of accidental contamination or injury from these materials. In the event of such an accident, we could be held liable for any damages that result, and any such liability could exceed our resources. Moreover, as our
business develops we may be required to incur significant costs to comply with federal, state and local environmental laws, regulations and policies, especially to the extent that we manufacture our own products.





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Management and Principal Stockholders May Be Able to Exert Significant Control On Matters Requiring Approval by Our
Stockholders and Security Interests in Our Assets Held by Management May Enable Them to Control the Disposition of Such Assets



As of March 26, 2004, our management and principal stockholders together beneficially owned approximately 20% of our outstanding shares of common stock.
As a result, these stockholders, acting together, may be able to effectively control all matters requiring approval by our stockholders, including the election of a majority of our directors and the approval of business combinations.



In July 2003, we issued a $400,000 short-term senior secured note payable to
one of our officers who is also a member our board of directors for cash. This note bears interest at a rate of five and one-half percent (5.5%) and is due on the earlier to occur of March 31, 2007 and 30 days subsequent to the successful completion
of a pivotal Phase III clinical trial with ISV 401 and is secured by a lien on substantially all of our assets including our intellectual property and certain other equipment secured by the lessor of such equipment.



This security interest enables this member of our board of directors and
management to control the disposition of these assets in the event of our liquidation. If we are unable to repay the amounts due under this note, this director and officer could, or cause us to, enter into involuntary liquidation proceedings in the
event we default on our obligation.



In addition, investors in
our March 2004 private placement, as a group, own approximately 17% of our outstanding shares of common stock. If the final closing occurs, we anticipate that such investors would own approximately 63% of our then outstanding shares of common stock.
As a result, these stockholders, acting together, may be able to effectively control all matters requiring approval by our stockholders, including the election of a majority of our directors and approval of business combinations.



The Market Prices For Securities of Biopharmaceutical and Biotechnology Companies such as
Ours Have Been and Are Likely to Continue to Be Highly Volatile Due to Reasons that Are Related and Unrelated to the Operating Performance and Progress of Our Company



The market prices for securities of biopharmaceutical and biotechnology companies, including ours, have been highly
volatile. The market has from time to time experienced significant price and volume fluctuations that are unrelated to the operating performance of particular companies. In addition, future announcements and circumstances, such as our current
financial condition, the audit report included in this filing that includes an explanatory paragraph referring to our recurring operating losses and a substantial doubt about our ability to continue as a going concern, our ability to obtain new
financing, the results of testing and clinical trials, the status of our relationships with third-party collaborators, technological innovations or new therapeutic products, governmental regulation, developments in patent or other proprietary
rights, litigation or public concern as to the safety of products developed by us or others and general market conditions, concerning us, our competitors or other biopharmaceutical companies, may have a significant effect on the market price of our
common stock.



Further, conversions of convertible securities
and the sale of the shares of our Common Stock underlying those convertible securities, such as the debentures issued to HEM and the warrants issued to Xmark and others, could cause a significant decline in the market price for our common stock.
Additionally, both the debentures issued to HEM and the warrants issued to Xmark contain anti-dilution provisions that would decrease the conversion or exercise price of these instruments and, in the case of the Xmark warrants, result in an increase
in the number of shares of our common stock issuable under them. We have not paid any cash dividends on our common stock, and we do not anticipate paying any dividends on our common stock in the foreseeable future.



In addition, the terrorist attacks in the U.S. and abroad, the U.S.
retaliation for these attacks, the war in Iraq and continued worldwide economic weakness and the related decline in consumer confidence have had, and may continue to have, an adverse impact on the U.S. and world economy. These and similar events, as
well as, fluctuations in our operating results and market conditions for biopharmaceutical and biotechnology stocks in general, could have a significant effect on the volatility of the market price for our common stock and on the future price of our
common stock.



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We Have Adopted and Are Subject to Anti-Takeover Provisions That Could Delay or Prevent an Acquisition of Our Company



Provisions of our certificate of incorporation and bylaws
may constrain or discourage a third party from acquiring or attempting to acquire control of us. Such provisions could limit the price that investors might be willing to pay in the future for shares of our common stock. Our board of directors has
the authority to issue up to 5,000,000 shares of preferred stock, 15,000 of which have been designated as Series A-1 Preferred Stock. Our board of directors has the authority to determine the price, rights, preferences, privileges and restrictions
of the remaining unissued shares of preferred stock without any further vote or action by the stockholders. The rights of the holders of common stock will be subject to, and may be adversely affected by, the rights of the holders of any preferred
stock that may be issued in the future. The issuance of preferred stock, while providing desirable flexibility in connection with possible financings, acquisitions and other corporate purposes, could have the effect of making it more difficult for a
third party to acquire a majority of our outstanding voting stock. Provisions of Delaware law applicable to us could also delay or make more difficult a merger, tender offer or proxy contest involving us, including Section 203 of the Delaware
General Corporation Law, which prohibits a Delaware corporation from engaging in any business combination with any interested stockholder for a period of three years unless conditions set forth in the Delaware General Corporation Law are met.



We Have Convertible, Redeemable Securities That Have and May Continue To
Result in Dilution for Common Stockholders, and May Be Convertible Into Common Stock or Debt



As a result of our merger with Ophthalmic Solutions Inc. on September 22, 2003, we assumed the rights and obligations in connection with $1,000,000 in
principal amount of convertible debentures issued by Ophthalmic Solutions to HEM, including the gross proceeds raised through the sale of the debentures and Ophthalmic Solutions obligations under the debentures and the related debenture
purchase agreement. The debentures are convertible into shares of our Common Stock, accrue interest at the rate of 1% per year, payable in cash or shares of our Common Stock, and have a maturity date of September 21, 2008. As of the date of this
filing, an aggregate of $982,329 in principal amount of these debentures, along with the associated interest, had been converted into an aggregate of 3,763,651 unrestricted shares of our Common Stock. As of the date of this filing, the remaining
$17,724 in principal amount and accrued interest of the debentures is convertible into unrestricted shares of our Common Stock at a conversion price that is the lower of $0.35394 or the average of the three lowest closing per share bid prices for
our Common Stock during the 40 trading days prior to conversion. The conversion price reflects anti-dilution adjustments that were triggered by the initial closing of the private placement. Additional anti-dilution adjustments are likely to be
triggered by the final closing of the private placement, if such debentures are outstanding at that time.



EXECUTIVE OFFICERS AND OTHER SENIOR MANAGEMENT OF THE REGISTRANT



As of March 30, 2004, our executive officers and other senior management were as follows:



|                               |  |     |  |                                                                                      
|------------------------------ |  | --- |  | -------------------------------------------------------------------------------------
|Name                           |  | Age |  | Title                                                                                
|S. Kumar Chandrasekaran, Ph.D. |  | 61  |  | Chairman of the Board, President, Chief Executive Officer and Chief Financial Officer
|Lyle M. Bowman, Ph.D.          |  | 55  |  | Vice President, Development and Operations                                           
|David F. Heniges               |  | 60  |  | Vice President and General Manager, Commercial Opportunities                         
|Cheryl E. Chen                 |  | 44  |  | Senior Director, Clinical Operations                                                 
|Sandra C. Heine                |  | 42  |  | Senior Director, Finance and Administration                                          
|Erwin C. Si, Ph.D.             |  | 50  |  | Senior Director, Preclinical Research                                                



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S. Kumar Chandrasekaran joined us in September 1987 as Vice President, Development. From 1988 to 1989,
Dr. Chandrasekaran served as Vice President, Research and Development. From 1989 to 1993, he served as President and Chief Operating Officer. Since August 1993, Dr. Chandrasekaran has served as Chairman of the Board of Directors, President, Chief
Executive Officer and, since January 1999, as Chief Financial Officer, a position he also held from December 1995 to December 1997. Dr. Chandrasekaran holds a Ph.D. in Chemical Engineering from the University of California, Berkeley.



Lyle M. Bowman joined us in October 1988 as Director of Drug Delivery
Systems. From 1989 to 1991, Dr. Bowman served as Vice President, Science and Technology. From 1991 to 1995, he served as Vice President, Development, and since 1995 has served as Vice President Development and Operations. Dr. Bowman holds a Ph.D. in
Physical Chemistry from the University of Utah.



David Heniges
joined us in July 2002 as Vice President and General Manager, Commercial Opportunities. From 1998 to 2001, Mr. Heniges served as General Manager-Europe/Africa/Middle East for Kera Vision, Inc., a manufacturer of implantable ophthalmic devices and
equipment. From 1996 to 1998 he was Vice President, Global Marketing for the cardiovascular group at Baxter Healthcare Corporation. From 1982 to 1995 he served in various managerial positions, including Director, Product Management and International
Marketing, Vice President, Marketing, and Vice President, Worldwide Business Development, at IOLAB Corporation, a Johnson & Johnson company, which manufactured ophthalmic devices, equipment and pharmaceuticals. Mr. Heniges holds a B.S. in
Sociology with a minor in science from Oregon State University.



Cheryl E. Chen joined us in January 1990 as the Manager of Clinical Research. From 1994 to 1998, Ms. Chen served as Director of Clinical Operations. In 1999, Ms. Chen became the Senior Director of Clinical Operations. Ms. Chen holds a B.S.
in Biological Science from University of California at Irvine and an M.B.A. in Business from Pepperdine University.



Sandra C. Heine joined us in March 1997 as Controller. Since October 1999, Ms. Heine has served as Senior Director of Finance and Administration. Ms.
Heine holds a B.S. in Business Administration from Colorado State University.



Erwin C. Si joined us in April 1989 as Manager of Pharmacology and Toxicology. From 1992 to 1996, he served as Manager of Drug Discovery. From 1996 to 1999, he served as Principal Scientist. Since October 1999, he has
served as Senior Director of Preclinical Research. Dr. Si holds a Ph.D. in Pharmacology and Toxicology from Purdue University.



Officers are appointed to serve, at the discretion of the Board of Directors, until their successors are appointed. There are no family relationships
between any members of our Board of Directors and our executive officers.



|Item 2. | Properties
|------- | ----------



We currently lease approximately 29,402 square feet of research laboratory and office space located in Alameda, California. The facility includes
laboratories for formulation, analytical, microbiology, pharmacology, quality control and development as well as a pilot manufacturing plant. The lease expires on December 31, 2006, and may be renewed by us for an additional 5-year term. We believe
our existing facilities will be suitable and adequate to meet our needs for the immediate future.



|Item 3. | Legal Proceedings.
|------- | ------------------



On June 23, 2003, Xmark Funds, L.P. etal, or Xmark, filed a complaint in the United States District Court, Southern District of New York against us
alleging that we breached the terms of the term sheet signed between Xmark and us in May 2003. On December 31, 2003 we settled the suit with Xmark. As part of the settlement, we paid Xmark $10,000 and issued Xmark warrants to purchase 250,000 shares
of our common stock at an exercise price of $0.58 per share. Pursuant to certain anti-dilution adjustments set forth in the warrants, our March 2004 private placement triggered an adjustment to the Xmark warrants such that the warrants are now
exercisable for the purchase of 254,386 shares of our common stock at an exercise price of $0.57 per share. In addition, the warrants issued to Xmark include piggyback registration rights which entitle Xmark to require us to include the shares
issuable upon exercise of the warrants in the



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registration statement to be filed by us in connection with our March 2004 private placement. If the shares issuable upon exercise of the warrants issued to
Xmark are not registered prior to June 30, 2004, the expiration date of such warrants is extended to December 31, 2008.



On or about October 8, 2003, a former consultant filed a complaint in the Superior Court of California, County of San Francisco against us, our
chief executive officer, Kumar Chandrasekaran, the Regents of the University of California, or Regents, and two individuals associated with Regents. In essence, he alleges that we breached an obligation to continue supporting his
research; he has also made a variety of other related claims and allegations against us and the other defendants. He filed a motion to enjoin us, during the pendency of the litigation, from alienating the license rights held by us relating to the
subject of his research, and this motion was denied. We and Dr. Chandrasekaran filed a demurrer challenging certain aspects of the complaint which was heard on January 28, 2004. The Court has not yet issued a ruling on the demurrer, and until that
ruling issues we do not expect any further response to the complaint to be filed by either us or by Dr. Chandrasekaran.



While the amount of monetary relief is not specifically quantified in the complaint, in general he seeks to enforce a claimed agreement which states that
we would pay him between $100,000 and $200,000 in annual laboratory support for the life of patent, which corresponds to the certain TIGR patents licensed from the University of California for the diagnosis of glaucoma, and
bonus payments of approximately $60,000. He also seeks relief in connection with 30,000 shares of our Common Stock provided to him by us but which he gave back to us at the direction of Regents. The complaint also seeks unspecified punitive damages,
attorneys fees and other damages and relief (including an exclusive, royalty free license to certain patents relating to the glaucoma genetics program).



|Item 4. | Submission of Matters to a Vote of Security Holders.
|------- | ----------------------------------------------------



On December 12, 2003, we held our Annual Meeting of Stockholders at which the stockholders approved:



|(1) | The election of S. Kumar Chandrasekaran, Ph.D., Mitchell H. Friedlaender, M.D., John L. Mattana, Jon S. Saxe and Anders P. Wiklund to the board of Directors to serve until the next
annual meeting or until their successors are elected and qualified. The following directors received the number of votes set opposite their respective names:
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|                               |  |              |  |          
|------------------------------ |  | ------------ |  | ---------
|                               |  | For Election |  | Withheld 
|S. Kumar Chandrasekaran, Ph.D. |  | 21,289,528   |  | 842,975  
|Mitchell H. Friedlaender, M.D. |  | 21,902,753   |  | 229,750  
|John L. Mattana                |  | 20,702,058   |  | 1,430,445
|Jon S. Saxe                    |  | 21,495,488   |  | 637,015  
|Anders P. Wiklund              |  | 21,456,188   |  | 676,315  



PART II



|Item 5. | Market for Registrants Common Equity, Related Stockholder Matters and Issuer Purchases of Securities
|------- | -----------------------------------------------------------------------------------------------------



Market Information



Since June 10, 1998, our common stock has traded on The American Stock Exchange under the symbol ISV. From our
initial public offering on October 18, 1993 until June 9, 1998, our common stock traded on The Nasdaq National Market under the symbol INSV. Prior to our initial public offering, there was no public market for our common stock. The
following table sets forth the high and low sales prices for our common stock as reported by The American Stock Exchange for the periods indicated. These prices do not include retail mark-ups, mark-downs or commissions.



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|               |  |      |      |     |   |     
|-------------- |  | ---- | ---- | --- | - | ----
|2003           |  | High |      | Low
|First Quarter  |  | $    | 1.00 |     | $ | 0.63
|Second Quarter |  | $    | 0.70 |     | $ | 0.53
|Third Quarter  |  | $    | 0.66 |     | $ | 0.45
|Fourth Quarter |  | $    | 0.69 |     | $ | 0.33
|               |  |     
|2002           |  | High |      | Low
|First Quarter  |  | $    | 2.50 |     | $ | 1.74
|Second Quarter |  | $    | 2.17 |     | $ | 1.40
|Third Quarter  |  | $    | 1.55 |     | $ | 0.89
|Fourth Quarter |  | $    | 1.19 |     | $ | 0.62



Holders



As of March 25, 2004, we had approximately 300 stockholders of record. On
March 25, 2004, the last sale price reported on The American Stock Exchange for our common stock was $0.94 per share.



Dividends



We have never declared or paid dividends on our common stock and do not anticipate paying any cash dividends in the foreseeable future. It is the present
policy of our Board of Directors to retain our earnings, if any, for the development of our business.



Equity Compensation Plan Information



Information regarding our equity compensation plans is set forth in the section entitled Equity Compensation Plan Information in our Proxy Statement for our Annual Meeting of Stockholders which is expected
to be held on June 1, 2004 which information is incorporated herein by reference.



Recent Sales of Unregistered Securities



On
September 22, 2003, we issued warrants to purchase 81,967 shares of common stock for $0.61 until September 2008 to a financial advisor as part of the initial placement of convertible notes payable. On November 2003, we issued warrants to purchase
125,000 shares of common stock for $0.40 that expire in November 12, 2008 to a financial advisor as part of the placement of convertible notes payable. These securities were sold pursuant to an exemption provided by Section 4(2) of the Securities
Act of 1933, as amended, based on the limited nature of the offering and the financial advisors status as an accredited investor.



On December 16, 2003, we sold 142,857 shares of our common stock in a private placement to an accredited investor and received $50,000 in proceeds. These
securities were sold pursuant to an exemption provided by Section 4(2) of the Securities Act of 1933, as amended, based on the limited nature of the offering and the purchasers status as an accredited investor.



On December 31, 2003, we entered into a settlement agreement with Xmark
Funds, L.P. et al, or Xmark, related to a complaint filed against us by Xmark. As part of the settlement we paid Xmark $10,000 and issued warrants to purchase 250,000 shares of our Common Stock at an exercise price of $0.58 per share that expire on
December 31, 2006. These securities were sold pursuant to an exemption provided by Section 4(2) of the Securities Act of 1933, as amended, based on the limited nature of the offering and the purchasers status as an accredited investor.
Pursuant to certain anti-dilution adjustments set forth in the warrants, our March 2004 private placement triggered an adjustment to the Xmark warrants such that the warrants are now exercisable for the purchase of 254,386 shares of our common stock
at an exercise price of $0.57 per share. In addition, the warrants issued to Xmark include piggyback registration rights which entitle Xmark to require us to include the shares issuable upon exercise of the warrants in the registration statement to
be filed by us in connection with our March 2004 private placement. If the shares issuable upon exercise of the warrants issued to Xmark are not registered prior to June 30, 2004, the expiration date of such warrants is extended to December 31,
2008.



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On March 26, 2004, we completed the initial closing of a private placement to accredited investors of
shares of our common stock and warrants to purchase shares of common stock pursuant to subscription agreements entered into between us and such investors. These securities were sold pursuant to Rule 506 promulgated under the Securities Act of 1933,
as amended and pursuant to an exemption provided by Section 4(2) of the Securities Act of 1933, as amended. Pursuant to the terms of the subscription agreements the subscribers agreed to purchase from us an aggregate of 1,650 units, of which 194
units, consisting of an aggregate of 3,880,000 shares of our common stock and warrants to purchase 1,940,000 shares of our common stock were sold at the initial closing and the remaining 1,456 units, consisting of an aggregate of 29,120,000 shares
of our common stock and warrants to purchase 14,560,000 shares of our common stock, will be sold at the final closing. The final closing is subject to and conditioned upon approval of such closing and the transactions contemplated thereby by our
stockholders and certain other conditions set forth in the subscription agreements.



Each unit consists of 20,000 shares of common stock at $0.50 per share, redeemable Class A warrants exercisable for 5,000 shares at an exercise price of $0.75 per share and redeemable Class B
warrants exercisable for 5,000 shares at an exercise price of $0.75 per share. The Class A Warrants and Class B Warrants may be exercised at any time prior to the earlier of the date on which they are redeemed and the fifth anniversary of their
issuance. Outstanding Class A Warrants may be redeemed by us upon 30 days advanced written notice to the holder at a per warrant share redemption price of $0.75 if the average closing price of the common stock on the American Stock Exchange for any
20 consecutive trading days is at least $1.50. Outstanding Class B Warrants may be redeemed by us upon 30 days advanced written notice to the holder at a per warrant share redemption price of $1.75 if the average closing price of the common stock on
the American Stock Exchange for any 20 consecutive trading days is at least $2.50. The Class A Warrants and Class B Warrants are referred to as the Warrants, the shares of common stock issuable upon exercise of the Warrants are referred
to as the Warrant Shares and the term Securities means collectively the shares of Common stock included in the units, the Warrants and the Warrant Shares.



Paramount BioCapital, Inc. acted as the placement agent for the private placement and will received approximately $120,000
in fees for such services in the initial closing. In addition, if the final closing occurs, the placement agent will receive a non-redeemable five year warrant exercisable for 750,000 shares of common stock at an exercise price of $0.55 per share
and will receive additional fees for services. As long as the placement agent and its affiliates beneficially own at least 33% of the Securities issued to them in the private placement, the placement agent will be entitled to designate a nonvoting
observer who may attend all meetings of our Board of Directors.



The final closing will not occur, and we will not issue any common stock or Warrants at the final closing or receive any proceeds therefore, unless we receive approval from our stockholders to:



| |  | issue the subscribers the balance of the common stock and Warrants (including any shares of common stock issuable upon exercise thereof) included in the units subscribed for by the
subscribers and not issued at the initial closing;
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  | issue to the placement agent the placement warrants (including any shares of common stock issuable upon exercise of the placement warrants) and
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------



| |  | amend our Certificate of Incorporation to increase the authorized number of shares of common stock in an amount sufficient to issue the shares of common stock to be sold at the
final closing and the shares of common stock issuable upon the exercise of the Warrants and the placement warrants.
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



If we do not receive stockholder approval within 90 days of the initial closing, subject to certain limited extensions (the Termination Date),
the obligation of each subscriber to purchase the balance of the Securities in the final closing will be terminable at the option of the subscriber. In addition, if stockholder approval is not obtained by the Termination Date, we are required to pay
the subscribers liquidated damages equal in the aggregate to 2% of the gross proceeds received at the initial closing, for each week beyond the Termination Date that stockholder approval is not obtained, up to a maximum of 8% in the aggregate of the
gross proceeds received at the initial closing.



In addition,
not later than 15 days after the final closing, we are required to file a registration statement with the Securities and Exchange Commission, or the SEC, with respect to the resale of the shares



32



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##### Table of Contents

of Common stock (i) included in the units; (ii) issuable upon exercise of the Warrants included in the units; (iii) issuable upon exercise of the placement
warrants, and issuable pursuant to any penalties under the subscription agreements (collectively, the Registrable Shares). If we fail to file the registration statement within such period, we are required to issue to the subscribers (on
a pro-rata basis) additional Class B Warrants to purchase a number of shares of common stock equal to 1% of the shares of common stock, on a fully diluted basis, issued to subscribers in the private placement for each 15 day period the registration
statement remains unfiled, up to a maximum of Class B Warrants in the aggregate (on a pro-rata basis) to purchase an additional 4% of the common stock, on a fully diluted basis, issued to subscribers in the private placement.



If we do not receive stockholder approval by 15 days after the Termination
Date, we must file a registration statement with the SEC with respect to the resale of the shares of common stock (i) included in the units sold in the initial closing and (ii) issuable upon exercise of the Warrants included in the units sold in the
initial closing. If we fail to file the registration statement within such period then it is required to pay to subscribers (on a pro-rata basis) a cash payment equal to 1% of the gross proceeds raised in the initial closing for each 15 day period
the registration statement remains unfiled, up to a maximum (on a pro-rata basis) of 4% of the initial closing gross proceeds.



Issuer Purchases of Securities



None.



33



---

##### Table of Contents

|Item 6. | Selected Financial Data
|------- | -----------------------



The comparability of the following selected financial data is affected by a variety of factors, and this data is qualified by reference to and should be read in
conjunction with the consolidated financial statements and notes thereto elsewhere in this Annual Report on Form 10-K and the following Managements Discussion and Analysis of Financial Condition and Results of Operations. The following table
sets forth selected consolidated financial data for us for the five years ended December 31, 2003 (in thousands except per share amounts):



|                                                                                                                 |  |                         |        |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |        |  
|---------------------------------------------------------------------------------------------------------------- |  | ----------------------- | ------ | - | ---- | - | ------- | ---- |  | - | ------ | - |  | ---- | ------ | - |  | - | ------ | -
|                                                                                                                 |  | Year Ended December 31, |       
|                                                                                                                 |  | 2003                    |        |   | 2002 |   |         | 2001 |  |   | 2000   |   |  | 1999 |       
|Consolidated Statements of Operations Data                                                                       |  |                         |        |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |        |  
|Revenues, net                                                                                                    |  | $                       | 134    |   |      | $ | 36      |      |  | $ | 5      |   |  | $    | 4,513  |   |  | $ | 4,760  |  
|Cost of goods                                                                                                    |  |                         | 20     |   |      |   | 114     |      |  |   |       |   |  |      |       |   |  |   |       |  
|Operating expenses:                                                                                              |  |                         |        |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |        |  
|Research and development, net                                                                                    |  |                         | 4,436  |   |      |   | 6,911   |      |  |   | 6,610  |   |  |      | 1,674  |   |  |   | 1,397  |  
|Selling, general and administrative                                                                              |  |                         | 3,021  |   |      |   | 4,022   |      |  |   | 3,523  |   |  |      | 2,584  |   |  |   | 2,293  |  
|                                                                                                                 |  |                         |        |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |        |  
|Total expenses                                                                                                   |  |                         | 7,457  |   |      |   | 10,933  |      |  |   | 10,133 |   |  |      | 4,258  |   |  |   | 3,690  |  
|Gain on sale of assets                                                                                           |  |                         | 1,153  |   |      |   |        |      |  |   |       |   |  |      |       |   |  |   |       |  
|Interest and other income (expense), net                                                                         |  |                         | (561   | ) |      |   | 62      |      |  |   | 572    |   |  |      | 791    |   |  |   | 85     |  
|                                                                                                                 |  |                         |        |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |        |  
|Net income (loss) before taxes                                                                                   |  |                         | (6,751 | ) |      |   | (10,949 | )    |  |   | (9,556 | ) |  |      | 1,046  |   |  |   | 1,155  |  
|Income tax provision                                                                                             |  |                         |       |   |      |   |        |      |  |   |       |   |  |      |       |   |  |   | 5      |  
|                                                                                                                 |  |                         |        |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |        |  
|Net income (loss) before cumulative effect of accounting change                                                  |  |                         | (6,751 | ) |      |   | (10,949 | )    |  |   | (9,556 | ) |  |      | 1,046  |   |  |   | 1,150  |  
|Cumulative effect of accounting change(1)                                                                        |  |                         |       |   |      |   |        |      |  |   |       |   |  |      | (4,486 | ) |  |   |       |  
|                                                                                                                 |  |                         |        |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |        |  
|Net income (loss)                                                                                                |  |                         | (6,751 | ) |      |   | (10,949 | )    |  |   | (9,556 | ) |  |      | (3,440 | ) |  |   | 1,150  |  
|Non cash preferred dividend                                                                                      |  |                         | 221    |   |      |   | 48      |      |  |   |       |   |  |      | 3      |   |  |   | 22     |  
|                                                                                                                 |  |                         |        |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |        |  
|Net income (loss) applicable to common stockholders                                                              |  | $                       | (6,972 | ) |      |   | (10,997 | )    |  | $ | (9,556 | ) |  | $    | (3,443 | ) |  | $ | 1,128  |  
|                                                                                                                 |  |                         |        |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |        |  
|Basic earnings (loss) per share:                                                                                 |  |                         |        |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |        |  
|Net income (loss) per share applicable to common stockholders before cumulative effect of accounting change      |  | $                       | (0.27  | ) |      | $ | (0.44   | )    |  | $ | (0.38  | ) |  | $    | 0.04   |   |  | $ | 0.06   |  
|Cumulative effect of accounting change(1)                                                                        |  |                         |       |   |      |   |        |      |  |   |       |   |  |      | (0.19  | ) |  |   |       |  
|                                                                                                                 |  |                         |        |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |        |  
|Net income (loss) per share applicable to common stockholders                                                    |  | $                       | (0.27  | ) |      | $ | (0.44   | )    |  | $ | (0.38  | ) |  | $    | (0.15  | ) |  | $ | 0.06   |  
|                                                                                                                 |  |                         |        |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |        |  
|Diluted earnings (loss) per share:                                                                               |  |                         |        |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |        |  
|Net income (loss) per share applicable to common stockholders before cumulative effect of accounting change      |  | $                       | (0.27  | ) |      | $ | (0.44   | )    |  | $ | (0.38  | ) |  | $    | 0.04   |   |  | $ | 0.06   |  
|Cumulative effect of accounting change(1)                                                                        |  |                         |       |   |      |   |        |      |  |   |       |   |  |      | (0.18  | ) |  |   |       |  
|                                                                                                                 |  |                         |        |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |        |  
|Net income (loss) per share applicable to common stockholders                                                    |  | $                       | (0.27  | ) |      | $ | (0.44   | )    |  | $ | (0.38  | ) |  | $    | (0.14  | ) |  | $ | 0.06   |  
|                                                                                                                 |  |                         |        |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |        |  
|Pro-forma net income (loss) assuming the accounting change is applied retroactively                              |  | $                       | (6,972 | ) |      | $ | (10,997 | )    |  | $ | (9,556 | ) |  | $    | 1,043  |   |  | $ | (3,358 | )
|                                                                                                                 |  |                         |        |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |        |  
|Pro-forma net income (loss) per share assuming the accounting change is applied retroactively, basic and diluted |  | $                       | (0.27  | ) |      | $ | (0.44   | )    |  | $ | (0.38  | ) |  | $    | 0.04   |   |  | $ | (0.17  | )
|                                                                                                                 |  |                         |        |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |        |  
|Shares used to calculate basic net income (loss) per share                                                       |  |                         | 25,767 |   |      |   | 24,997  |      |  |   | 24,897 |   |  |      | 23,574 |   |  |   | 19,285 |  
|                                                                                                                 |  |                         |        |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |        |  
|Shares used to calculate diluted net income (loss) per share                                                     |  |                         | 25,767 |   |      |   | 24,997  |      |  |   | 24,897 |   |  |      | 24,483 |   |  |   | 19,856 |  
|                                                                                                                 |  |                         |        |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |        |  
|Shares used to calculate pro-forma basic net income (loss) per share                                             |  |                         | 25,767 |   |      |   | 24,997  |      |  |   | 24,897 |   |  |      | 23,574 |   |  |   | 19,285 |  
|                                                                                                                 |  |                         |        |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |        |  
|Shares used to calculate pro-forma diluted net income (loss) per share                                           |  |                         | 25,767 |   |      |   | 24,997  |      |  |   | 24,897 |   |  |      | 24,483 |   |  |   | 19,285 |  
|                                                                                                                 |  |                         |        |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |        |  



|(1) | Reflects the impact of the adoption of SAB 101 on revenue recognition effective January 1,
2000.
|--- | ------------------------------------------------------------------------------------------------



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|                                     |  |              |          |   |      |   |          |      |  |   |         |   |  |      |         |   |  |   |         |  
|------------------------------------ |  | ------------ | -------- | - | ---- | - | -------- | ---- |  | - | ------- | - |  | ---- | ------- | - |  | - | ------- | -
|                                     |  | December 31, |         
|                                     |  | 2003         |          |   | 2002 |   |          | 2001 |  |   | 2000    |   |  | 1999 |        
|Consolidated Balance Sheet Data      |  |              |          |   |      |   |          |      |  |   |         |   |  |      |         |   |  |   |         |  
|Cash and cash equivalents            |  | $            | 1,045    |   |      | $ | 1,179    |      |  | $ | 10,095  |   |  | $    | 18,904  |   |  | $ | 6,746   |  
|Working capital                      |  |              | (6,434   | ) |      |   | 353      |      |  |   | 8,747   |   |  |      | 18,305  |   |  |   | 6,167   |  
|Total assets                         |  |              | 1,405    |   |      |   | 1,866    |      |  |   | 11,051  |   |  |      | 20,000  |   |  |   | 7,463   |  
|Long term notes payable              |  |              |         |   |      |   | 10       |      |  |   | 45      |   |  |      | 26      |   |  |   |        |  
|Redeemable preferred stock           |  |              |         |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   | 30      |  
|Convertible preferred stock          |  |              |         |   |      |   | 2,048    |      |  |   |        |   |  |      |        |   |  |   |        |  
|Accumulated deficit                  |  |              | (115,722 | ) |      |   | (108,750 | )    |  |   | (97,753 | ) |  |      | (88,197 | ) |  |   | (84,754 | )
|Total stockholders equity (deficit) |  |              | (6,200   | ) |      |   | 887      |      |  |   | 9,485   |   |  |      | 18,770  |   |  |   | 6,256   |  



No cash dividends have been declared
or paid by us since our inception.



|Item 7. | Managements Discussion and Analysis of Financial Condition and Results of Operations
|------- | -------------------------------------------------------------------------------------



Except for the historical information contained herein, the discussion in this Annual Report on Form 10-K contains
certain forward-looking statements that involve risks and uncertainties, such as statements of our plans, objectives, expectations and intentions. The cautionary statements made in this document should be read as applicable to all related
forward-looking statements wherever they appear in this document. Our actual results could differ materially from those discussed herein. Factors that could cause or contribute to such differences include those discussed below in Risk
Factors, as well as those discussed elsewhere herein. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. We undertake no obligation to update any forward- looking
statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events.



The following discussion should be read in conjunction with the financial statements and notes thereto included in Item 8 of this Form 10-K.



Overview



As of December 31, 2003, our accumulated deficit was approximately $115.7 million. Absent additional funding from final
closing of the private placement we entered into in March 2004 or other private or public equity or debt financings, collaborative or other partnering arrangements, or other sources, as of March 26, 2004 we expect that our cash on hand, anticipated
cash flow from operations and current cash commitments to us will only be sufficient to fund our operations until approximately the middle of June 2004. If we are unable to complete the final closing related to the March 2004 private placement,
there is no assurance that such additional funds will be available for us to finance our operations on acceptable terms, if at all. If such funds are not available, management will be required to cease all operations and liquidate our remaining
assets, most of which is secured by a note to an officer who is also a board member. The financial statements do not include any adjustments to reflect the possible future effects on the recoverability and classification of assets or the amounts and
classification of liabilities that may result from our inability to obtain funding and resultant ceasing of operations. There can be no assurance that we will ever achieve or be able to maintain either significant revenues from product sales or
profitable operations.



We are an ophthalmic product
development company focused on ophthalmic pharmaceutical products based on our proprietary DuraSite® eyedrop-based drug delivery technology, as well as developing genetically-based technology, for the diagnosis, prognosis and management of glaucoma. In addition, we have a retinal
program that includes both a therapeutic agent and a retinal drug delivery technology.



35



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In 2003 we faced significant challenges related to our lack of financial resources. To continue our
operations we took actions to reduce our cash usage including:



| |  | laying-off approximately 42% of our personnel;
| | - | ----------------------------------------------



| |  | our senior management voluntarily reduced their salaries;
| | - | ---------------------------------------------------------



| |  | we placed several development programs on hold including expansion of our ISV-900 technology, ISV-014 our retinal delivery device, and treatments for retinal diseases;
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  | slowed our clinical activities related to ISV-401; and
| | - | ------------------------------------------------------



| |  | we instituted other cash saving actions including extending the payment of our liabilities.
| | - | -------------------------------------------------------------------------------------------



With our limited resources we focused our research and development and commercial efforts on the following:



| |  | ISV-403, a DuraSite formulation of a fourth generation fluoroquinolone;
| | - | -----------------------------------------------------------------------



| |  | ISV-401, a DuraSite formulation of azithromycin, an antibiotic not currently used in ophthalmology; and
| | - | -------------------------------------------------------------------------------------------------------



| |  | targeted activities to support the market introduction of our OcuGene glaucoma genetic test based on our ISV-900 technology.
| | - | ----------------------------------------------------------------------------------------------------------------------------



ISV-403. In February 2003 we filed an IND for our ophthalmic
antibiotic product candidate ISV-403, which was the first milestone under the August 2002 license agreement with Bausch & Lomb and resulted in the receipt $2.0 million from the sale of Series A-1 Preferred Stock. In April 2003 we began a Phase 1
clinical trial of ISV-403 and in June 2003 the dosing for the study was completed. In December 2003 we sold the ISV-403 product candidate to Bausch & Lomb, which resulted in the receipt of $1.5 million in cash, the return of the $4.0 million of
Series A-1 Preferred Stock, and the related dividends, to us for cancellation, and provides for royalties on future product sales, if any. While we will be providing contract research services into the second quarter of 2004, due to the sale Bausch
& Lomb is responsible for the further clinical development of the product and we will be able to focus our development efforts on our ISV-401 product candidate.



ISV-401.We have developed a topical formulation of the antibiotic, azithromycin, a broad spectrum of antibiotic
activity and is widely used to treat respiratory and other infection in its oral and parenteral forms, to treat bacterial conjunctivitis and other infections of the outer eye. The key advantages of ISV-401 include a significantly reduced dosing
regimen (6 doses vs. 36 doses for comparable products), the high and persistent levels of azithromycin achieved in the tissues of the eye and its wide spectrum of activity. Product safety and efficacy have been demonstrated, respectively, in Phase 1
and Phase 2 clinical trials. As a result of our End of Phase 2 Meeting with the FDA early in 2003, we intended to initiate two pivotal Phase 3 clinical trials. Due to our financial constraints the initiation of the trials was delayed and
currently is planned for the second quarter of 2004. We anticipate conducting the trials in both the United States and internationally to permit aggressive enrollment of the subjects, including both children and adults, necessary to complete the
studies. We further anticipate that the primary endpoints of both trials will be microbial eradication and clinical cure. Our ability to execute on these clinical plans will be dependent upon the receipt of funds from the final closing related to
our March 2004 private placement.



In 2003 we secured a new
source for the active ingredient in ISV-401 and have a contract-manufacturing site for production of clinical trial supplies and registration batches. The supplies are being manufactured under the supervision of our personnel. We are planning to
begin manufacture the registration batches needed to support the filing of the NDA at this contract facility in the second quarter of 2004. We anticipate that our contract manufacturing facility will be ready for inspection by the FDA at the time of
our NDA submission.



OcuGene. Our OcuGene
glaucoma genetic test is based on our glaucoma genetics program, which has been pursued in collaboration with academic researchers, is focused on discovering genes that are associated with glaucoma, and the mutations on these genes that cause and
regulate the severity of the disease. In June 2003, a peer-reviewed study was published inClinical Genetics titled Association of the Myocilin mt.1 Promoter Variant with the Worsening of Glaucomatous Disease Over Time, (2003: 64:
18-27). The results of this study indicate substantial evidence that the TIGR/MYOC mt.1(+) variant provides a strong marker for accelerated worsening of both optic disc and visual field measures of glaucoma progression above and beyond other
baseline risk factors, stated one of the authors of the study, Jon Polansky, M.D., University of California, San Francisco, who also serves on our Scientific Advisory Board.



36



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##### Table of Contents

In 2003, the information from this article and previous publications was used to target specific thought
leaders and ophthalmic centers in an effort to support the focused introduction of the OcuGene glaucoma genetic test. Expanded marketing efforts were curtailed as we contained our cash use.



Since our inception through the end of 2001, we had not received any revenues
from the sale of our products, although we have received a small amount of royalties from the sale of our AquaSite product by CIBA Vision and Global Damon. In the fourth quarter of 2001, we commercially launched our OcuGene glaucoma genetic test and
early in 2002 we began to receive a small amount of revenues from the sale of this test. With the exception of 1999, we have been unprofitable on an annual basis since our inception due to continuing research and development efforts, including
preclinical studies, clinical trials and manufacturing of our product candidates. We have financed our research and development activities and operations primarily through private and public placement of our equity securities, issuance of
convertible debentures and, to a lesser extent, from collaborative agreements and bridge loans.



Critical Accounting Policies and Use of Estimates



The preparation of financial statements in conformity with generally accepted accounting principles in the U.S. requires us to make estimates and assumptions that affect the amounts reported in the financial
statements and accompanying notes. Actual results could differ from those estimates.



We believe the following policies to be the most critical to an understanding of our financial condition and results of operations because they require us to make significant estimates, assumptions and judgments about
matters that are uncertain:



Revenue Recognition. We
recognize up-front fees from licensing and similar arrangements over the expected term of the related research and development services using the straight-line method. When changes in the expected term of ongoing services are identified, the
amortization period for the remaining fees is appropriately modified.



Revenue related to performance milestones is recognized when the milestone is achieved based on the terms set forth in the related agreements.



Revenue related to contract research services is recognized when the services are provided and collectibility is reasonable assured.



We directly reduce expenses for amounts reimbursed due to cost sharing
agreements during the year ended December 31, 2002 and 2001. We recognize the received cost sharing payments when persuasive evidence of an arrangement exists, the services have been rendered, the fee is fixed or determinable and collectibility is
reasonably assured. During the year ended 2003, we recognized cost reimbursements as contract and other revenue in accordance with EITF 01-14, Income Statement Characterization of Reimbursement for Out of Pocket Expenses Incurred.



We receive royalties from licensees based on third-party sales
and the royalties are recorded as earned in accordance with contract terms, when third party results are reliably measured and collectibility is reasonably assured.



Revenue related to the sales of our product, the OcuGene glaucoma genetic test, is recognized when all related services have
been rendered and collectibility is reasonably assured. Accordingly, revenue for the sales of OcuGene may be recognized in a later period than the associated recognition of costs of the services provided, especially during the initial launch of the
product. The revenue in connection with the asset purchase agreement with Baush & Lomb will be recognized over the contract period.



Research and Development (R&D) Expenses. R&D expenses include salaries, benefits, facility costs, services provided by outside consultants
and contractors, administrative costs and materials for our research and development activities. We also fund research at a variety of academic institutions based on agreements that are generally cancelable. We recognize such costs as they are
incurred.



Cost of goods. We recognize the cost of
inventory shipped and other costs related to our OcuGene glaucoma genetic test when they are incurred.



Inventory. Our inventories are stated at the lower of cost or market. The cost of the inventory is based on the first-in first-out method. If the
cost of the inventory exceeds the expected market value a



37



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##### Table of Contents

provision is recorded for the difference between cost and market. At December 31, 2003, our inventories solely consisted of OcuGene kits.



Results of Operations



Revenues.



We had total net revenues of $134,000, $36,000, and $5,000 for the years ended December 31, 2003, 2002 and 2001, respectively, from contract research
activities, sales of OcuGene and sales of AquaSite®
by CIBA Vision and Kukje Pharma Ind. Co., Ltd., our AquaSite manufacturing partner in Korea. The increase in revenue is due to contract research activities conducted for Bausch & Lomb in 2003 under the ISV-403 Asset Purchase Agreement. We
recognize revenue when all services have been performed and collectibility is reasonably assured. Accordingly, revenue for the sales of OcuGene may be recognized in a later period than the associated recognition of costs of the services provided,
especially during the initial launch of the product.



Cost of goods.



Cost of goods of $20,000 and $114,000 for 2003 and 2002
respectively, reflect the cost of OcuGene tests performed as well as the cost of sample collection kits distributed for use. In 2002 a large number of OcuGene test kits were distributed, as the product was made initially available to interested
parties. A significantly lower number of units were shipped in 2003.



Research and development.



Research and
development expenses decreased to $4.4 million from $7.1 million in 2003 compared to 2002. This 38% decrease reflects the personnel cost containment actions taken in the second quarter of 2003 and the reduction in support for external research which
was begun in the first quarter of 2003. Additionally, costs incurred in 2002 for the license of the Optineuron gene from UCHC and the related cost of new patent filings, were not incurred in 2003 as the majority of the initial filings were completed
in 2002. R&D expenses in 2002 decreased 3% to $7.1 million from $7.3 million in 2001. This decrease mainly reflected a reduction in support for external research for our ISV-900 and ISV-014 programs as we focused our resources on the targeted
launch of OcuGene and on our antibiotic programs.



In 2003, we
received no R&D cost reimbursements. In 2002, our R&D cost reimbursements decreased 77% to $0.2 million from $0.7 million in 2001. The decrease reflected the termination of the ISV-205 license by Pharmacia in 2001. Cost reimbursement in 2002
related to joint development programs to evaluate compounds for ophthalmic use.



Our R&D activities can be separated into two major segments, research and clinical development. Research includes activities involved in evaluating a potential product and the related pre-clinical testing.
Clinical development includes activities related to filings with the FDA and the related human clinical testing required to obtain marketing approval for a potential product. We estimate that the following represents the approximate cost of these
activities for 2003, 2002 and 2001 (in thousands):



|                               |  |      |       |      |   |       |  |   |      
|------------------------------ |  | ---- | ----- | ---- | - | ----- |  | - | -----
|                               |  | 2003 |       | 2002 |   | 2001 
|Research                       |  | $    | 2,707 |      | $ | 4,860 |  | $ | 5,050
|Clinical development           |  |      | 1,729 |      |   | 2,217 |  |   | 2,273
|                               |  |      |       |      |   |       |  |   |      
|Total research and development |  | $    | 4,436 |      | $ | 7,077 |  | $ | 7,323
|                               |  |      |       |      |   |       |  |   |      



Due to our limited
personnel and the number of projects that we are developing, our personnel are involved in a number of projects at the same time. Accordingly, the majority of our R&D expenses are not linked to a specific project but are allocated across
projects, based on personnel time expended on each project. Accordingly, the allocated costs may not reflect the actual costs of each project.



The decrease in research activities in 2003 compared to 2002 reflects the cost containment efforts initiated in the second quarter of 2003. In May 2003,
we instituted a one-month furlough, which included 80% of our research personnel. In June 2003, approximately 75% of the furloughed research personnel were laid-off. In 2003 we also continued to reduce our financial support of the research related
to our genetics programs by not renewing certain research contracts pending the receipt of additional funding. In a further effort to reduce expenses, we have reviewed, and will continue to review, our patent filings and will



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discontinue maintenance of patents and patent applications related to programs that we have determined not to pursue. The decrease in research activities in
2002 compared to 2001 mainly represents the conversion of a portion of the ISV-900 research into the OcuGene glaucoma genetic test, which is in the initial marketing launch phase. Research is being conducted on other genes and genetic markers but at
a lower rate as our limited resources are used to support the commercialized technology. As much of this research is conducted at external academic centers, we were able to scale back this research without incurring termination costs.



The 22% decrease in Clinical development expenses from $2.2 million in 2002
to $1.7 million in 2003 reflects the cost containment efforts initiated across the company in the second quarter of 2003. In May 2003, we instituted a one-month furlough, which included 50% of our clinical development personnel. In June 2003,
approximately 83% of the furloughed clinical development personnel were laid-off. Additionally, clinical development costs related to the OcuGene glaucoma genetic test were reduced as the studies were completed in 2002 and no new studies were begun
in 2003. Clinical development expenses remained consistent between 2002 and 2001, as the clinical trial activity was comparable between the two years. We shifted the resources used to file the IND for ISV-401 in 2001 to similar activities on the
ISV-403 program in 2002.



Most of our projects are in the early
stages of the product development cycle and may not result in commercial products. Projects in development may not proceed into clinical trials due to a number of reasons even though the project looks promising early in the process. Once a project
reaches clinical trials it may be found to be ineffective or there may be harmful side effects. Additionally, during the development cycle, other companies may develop new treatments that decrease the market potential for our project and we may
decide not to proceed. Other factors including the cost of manufacturing at a commercial scale and the availability of quality manufacturing capabilities could negatively impact our ability to bring the project to the market. Also, our business
strategy is to license projects to third parties to complete the development cycle and to market and sell the product. If we are unable to enter into collaborative arrangements for any product candidate, our ability to commercialize the product may
be slowed or we may decide not to proceed with that candidate. These collaborative arrangements may either speed the development or they may extend the anticipated time to market. Because of these factors, as well as others, we cannot be certain if,
or when, our projects in development will complete the development cycle and be commercialized.



Selling, general and administrative.



Selling, general and administrative expenses decreased to $3.0 million in 2003 from $4.0 million in 2002. This reflects the approximately 79% decrease in selling expenses related to the initial market introduction of
OcuGene, such as advertising and our limited initial contract sales force. The remaining decrease includes a 47% decrease in personnel-related costs due to the impact of the employee furloughs, lay-offs and voluntary salary reductions. While our
legal costs related to our fund raising efforts and the cost of our insurance coverage, including directors and officers insurance increased approximately 56% in 2003 compared to 2002, these costs were more than offset by the other expense
containment measures.



Selling, general and administrative
expenses increased 14% in 2002 to $4.0 million from $3.5 million in 2001. The increase in 2002 reflects the additional costs incurred to support the ongoing launch of the OcuGene glaucoma genetic test. These costs included the addition of a V.P. of
Commercial Development, expanded promotional advertising and outreach activities into ophthalmic and optometric practices.



Gain on sale of assets.



The gain on sale of assets reflects the sale of the ISV-403 product candidate to Bausch & Lomb in December 2003. We received $1.5 million in cash and
Bausch & Lomb surrendered the $4.0 million of Series A-1 Preferred Stock, plus accumulated dividends, we had issued to them under the August 2002 License and Preferred Stock Purchase Agreements. The total gain will be recognized over the
five-month period that we have an obligation to provide contract research support for ISV-403, which began in December 2003.



Interest, other income and expenses.



Net interest, other income and expense was an expense of $561,000 in 2003 compared to income of $62,000 in 2002. This change principally reflects the
$545,000 of interest expense related to the debt



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discount of the convertible debentures, interest expense related to the short-term notes payable and to lower average cash balances. As of December 31, 2003
$1,000 of the debt discount remained and will be amortized over the life of the notes. Net interest, other income and expense was income of $62,000 in 2002 compared to income of $572,000 in 2001. This decrease is due principally to lower average
cash balances and decreased interest rates. Any interest earned or paid in the future will be dependent on our ability to raise additional funding and prevailing interest rates.



Liquidity and Capital Resources



We have financed our operations since inception primarily through private placements and public offerings of debt and equity securities, equipment and
leasehold improvement financing, other debt financing and payments under corporate collaborations. At December 31, 2003, our cash and cash equivalents balance was $1.0 million. It is our policy to invest our cash and cash equivalents in highly
liquid securities, such as interest bearing money market funds, Treasury and federal agency notes and corporate debt.



In March 2004, we received approximately $1.8 million, net of placement fees, from the initial closing of a total private placement that will yield
aggregate gross proceeds of $16.5 million. Our ability to receive the remainder of the funds at the final closing will be subject to receipt of stockholder approval of the final closing of the placement and of the increase in our authorized shares
necessary to issue both the Common Stock to be issued in the final closing of the placement and the Common Stock issuable upon the exercise of the warrants issued as part of the final closing of the placement, and satisfaction of other standard
conditions contained in the subscription agreements. We will be seeking the necessary stockholder approval at our annual meeting of stockholders, which is scheduled to take place on June 1, 2004.



Our auditors have included an explanatory paragraph in their audit report
referring to our recurring operating losses and a substantial doubt about our ability to continue as a going concern. Absent additional funding from the final closing related to the March 2004 private placement, other private or public equity or
debt financings, collaborative or other partnering arrangements, asset sales, or other sources, we expect that our cash on hand, anticipated cash flow from operations and current cash commitments to us will only be adequate to fund our operations
until approximately the middle of June 2004. Also, pursuant to the terms of the private placement we are generally prohibited from raising additional financing through the issuance of securities during the period from the initial closing through the
earlier to occur of the final closing and June 30, 2004 (subject to extension at our sole discretion), which could significantly harm our ability to continue operations of the final closing does not occur. If we are unable to complete the final
closing of the March 2004 private placement or secure sufficient additional funding prior to the middle of June 2004, we will need to cease operations and liquidate our assets, most of which is secured by a note to an officer who is also a board
member. Our financial statements were prepared on the assumption that we will continue as a going concern and do not include any adjustments that might result should we be unable to continue as a going concern.



Even if we are able to complete the final closing of the March 2004 private
placement, in order to continue long-term operations beyond approximately the third quarter of 2005, we will require and are seeking additional funding through collaborative or other partnering arrangements, public or private equity or debt
financings, asset sales and from other sources. However, there can be no assurance that we will obtain interim or longer-term financing or that such funding, if obtained, will be sufficient to continue our operations as currently conducted or in a
manner necessary for the long-term success of our company. If we raise funds through the issuance of debt securities, such debt will be secured by a security interest or pledge of all of our assets, will require us to make principal and interest
payments, would likely include the issuance of warrants and may subject us to restrictive covenants. In addition, our stockholders may suffer substantial dilution if we raise additional funds by issuing equity securities.



For the years ended December 31, 2003, 2002 and 2001, cash used for operating
activities was $5.6 million, $11.0 million and $8.4 million, respectively. Cash from (used in) investing activities were $1,477,000, ($61,000) and ($474,000) primarily related to proceeds received from the sale of assets and cash outlays for
additions to laboratory and other equipment made during 2003, 2002 and 2001, respectively.



Cash provided by financing activities was $4.0 million, $2.1 million and $0.1 million for the years ending December 31, 2003, 2002 and 2001, respectively. We received $2.0 million in the first quarter of 2003 from the
issuance of 2,000 shares of our Series A-1 preferred stock to Bausch & Lomb under the ISV-



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403 license agreement. We issued $1.0 million of short-term notes payable in 2003 to directors, members of senior management and other stockholders. These
notes bear interest at rates from 2% to 12% and are due from January 15, 2003 through March 31, 2007. We received $845,000, net of debt issuance costs of approximately $154,000, from the issuance of convertible debentures in 2003. These debentures
bear interest at a rate of 1% and are due on September 21, 2008. In 2003 we received $3,000 from the issuance of our common stock from the exercise of stock options by employees compared to $125,000 in 2002 and $71,000 in 2001. During 2003, we also
received $134,000 in connection with private placements of our common stock. We received payments on a note to a stockholder of $23,000 and $26,000 in 2003 and 2002, respectively. We also made $18,000 of payments on capital leases for certain
laboratory equipment in 2003 compared to $31,000 in 2002 and $7,000 in 2001.



Assuming we are able to obtain additional financing and continue our operations, our future capital expenditures and requirements will depend on numerous factors, including the progress of our clinical testing,
research and development programs and preclinical testing, the time and costs involved in obtaining regulatory approvals, our ability to successfully commercialize OcuGene and any other products that we may launch in the future, our ability to
establish collaborative arrangements, the cost of filing, prosecuting, defending and enforcing patent claims and other intellectual property rights, competing technological and market developments, changes in our existing collaborative and licensing
relationships, acquisition of new businesses, products and technologies, the completion of commercialization activities and arrangements, and the purchase of additional property and equipment.



We anticipate no material capital expenditures to be incurred for
environmental compliance in fiscal year 2004. Based on our environmental compliance record to date, and our belief that we are current in compliance with applicable environmental laws and regulations, environmental compliance is not expected to have
a material adverse effect on our operations.



Contractual Obligations



The following table summarizes our significant
contractual obligations as of December 31, 2003 and the effect such obligations are expected to have on our liquidity and cash flows in the future periods. This table excludes amounts already recorded on our balance sheet as current liabilities.



|                                   |  |                                       |       |                  |   |             |  |                   |       |  |   |   
|---------------------------------- |  | ------------------------------------- | ----- | ---------------- | - | ----------- |  | ----------------- | ----- |  | - | --
|                                   |  | Payments due by period (in thousands)
|                                   |  | Total                                 |       | Less than 1 year |   | 1 - 3 years |  | More than 5 years
|Operating lease obligations(1)     |  | $                                     | 2,230 |                  | $ | 718         |  | $                 | 1,512 |  | $ |  
|Licensing agreement obligations(2) |  |                                       | 120   |                  |   | 15          |  |                   | 45    |  |   | 60
|                                   |  |                                       |       |                  |   |             |  |                   |       |  |   |   
|Total commitments                  |  | $                                     | 2,350 |                  | $ | 733         |  | $                 | 1,557 |  | $ | 60
|                                   |  |                                       |       |                  |   |             |  |                   |       |  |   |   



|(1) | We lease our facilities under a non-cancelable operating lease that expires in 2006.
|--- | ------------------------------------------------------------------------------------



|(2) | We have entered into certain license agreements that require us to make minimum royalty
payments for the life of the licensed patents. The life of the patents which may be issued and covered by the license agreements cannot be determined at this time, but the minimum royalties due under such agreements are as noted for 2004 through
2011 and are approximately $15,000 per year until the first commercial sale, increase to $25,000 per year in the first three years of sales, and then increase to $40,000 per year until the expiration of the related patents.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Recent Accounting Pronouncements



In January 2003, the Financial Accounting Standards Board (FASB)
issued Interpretation No. 46 (FIN 46), Consolidation of Variable Interest Entities, an Interpretation of ARB No. 51. FIN 46 requires certain variable interest entities to be consolidated by the primary beneficiary of the
entity if the equity investors in the entity do not have the characteristics of a controlling financial interest or do not have sufficient equity at risk for the entity to finance its activities without additional subordinated financial support from
other parties. FIN 46 is effective immediately for all new variable interest entities created or acquired after January 31, 2003. For variable interest entities created or acquired prior to February 1, 2003, the provisions of FIN 46 must be applied
for the first interim or annual period beginning after December 15, 2003. We will adopt FIN 46 effective January 1, 2004. The adoption of FIN 46 is not expected to have a material impact on our financial position, results of operation or cash flows.



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In May 2003, the FASB issued Statement of Financial Accounting Standards No. 150 (SFAS 150),
Accounting for Certain Financial Instruments with Characteristics of both Liabilities and Equity. SFAS 150 establishes standards for how an issuer classifies and measures certain financial instruments with characteristics of both
liabilities and equity. It requires that an issuer classify a financial instrument that is within its scope as a liability (or an asset in certain circumstances). Many of these instruments were previously classified as equity. Although some of the
provisions of this statement are consistent with the current definition of liabilities in FASB Concepts Statement No. 6, Elements of Financial Statements, the remainder is consistent with FASBs intention to revise that definition
to encompass certain obligations that a reporting entity can or must settle by issuing its own shares. This statement is effective for financial instruments entered into or modified after May 31, 2003 and otherwise is effective at the beginning of
the first interim period beginning after June 15, 2003. There was no impact to the consolidated financial statements related to SFAS 150 for the year ended December 31, 2003.



|Item 7A. | Qualitative and Quantitative Disclosures About Market Risk
|-------- | ----------------------------------------------------------



The following discusses our exposure to market risk related to changes in interest rates.



We invest our excess cash in investment grade, interest-bearing securities.
At December 31, 2003, we had $1.0 million invested in money market mutual funds. While a hypothetical decrease in market interest rates by 10 percent from the December 31, 2003 levels would cause a decrease in interest income, it would not result in
a loss of the principal. Additionally, the decrease in interest income would not be material.



|Item 8. | Financial Statements and Supplementary Data
|------- | -------------------------------------------



The following Consolidated Financial Statements and Report of Independent Auditors are included on the pages that follow:



|                                                                                             |  |        
|-------------------------------------------------------------------------------------------- |  | -------
|                                                                                             |  | Page   
|Report of Independent Auditors                                                               |  | 43 - 44
|Consolidated Balance Sheets - December 31, 2003 and 2002                                     |  | 45     
|Consolidated Statements of Operations Years Ended December 31, 2003, 2002 and 2001           |  | 46     
|Consolidated Statements of Stockholders Equity Years ended December 31, 2003, 2002 and 2001 |  | 47     
|Consolidated Statements of Cash Flows Years Ended December 31, 2003, 2002 and 2001           |  | 48     
|Notes to Consolidated Financial Statements                                                   |  | 49 - 62



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Report of Burr, Pilger & Mayer LLP, Independent Auditors



The Board of Directors and Stockholders

InSite Vision Incorporated



We have audited the accompanying consolidated balance sheet of InSite Vision Incorporated as
of December 31, 2003, and the related consolidated statements of operations, stockholders equity (deficit) and cash flows for the year then ended. The consolidated financial statements are the responsibility of the Companys management.
Our responsibility is to express an opinion on these consolidated financial statements based on our audit.



We conducted our audit in accordance with auditing standards generally accepted in the United States of America. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether
the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used
and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audit provides a reasonable basis for our opinion.



In our opinion, the consolidated financial statements referred to above present fairly, in all material respects, the consolidated financial
position of InSite Vision Incorporated at December 31, 2003, and the consolidated results of its operations and its cash flows for the year then ended, in conformity with accounting principles generally accepted in the United States of America.



As discussed in Note 1 to the financial statements, the Companys
recurring losses from operations raise substantial doubt about its ability to continue as a going concern. Managements plans as to these matters are also described in Note 1. The 2003 financial statements do not include any adjustments that
might result from the outcome of this uncertainty.



/s/ Burr, Pilger & Mayer LLP



Palo Alto, California

March 12, 2004



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Report of Ernst & Young LLP, Independent Auditors



The Board of Directors and Stockholders

InSite Vision Incorporated



We have audited the accompanying consolidated balance sheet of InSite Vision Incorporated as of December 31, 2002, and the related consolidated statements
of operations, stockholders equity and cash flows for each of the two years in the period ended December 31, 2002. These consolidated financial statements are the responsibility of the Companys management. Our responsibility is to
express an opinion on these consolidated financial statements based on our audits.



We conducted our audits in accordance with auditing standards generally accepted in the United States. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the
financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and
significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.



In our opinion, the consolidated financial statements referred to above present fairly, in all material respects, the
consolidated financial position of InSite Vision Incorporated at December 31, 2002, and the consolidated results of its operations and its cash flows for each of the two years in the period ended December 31, 2002, in conformity with accounting
principles generally accepted in the United States.



The
accompanying consolidated financial statements have been prepared assuming InSite Vision Incorporated will continue as a going concern. As more fully described in Note 1, the Company has incurred recurring operating losses, has an accumulated
deficit as of December 31, 2002 of $108.8 million and does not currently have available sufficient funds to sustain its operations through fiscal year 2003. These conditions raise substantial doubt about the Companys ability to continue as a
going concern. Managements plans in regard to these matters are also described in Note 1. The financial statements do not include any adjustments to reflect the possible future effects on the recoverability and classification of assets or the
amounts and classification of liabilities that may result from the outcome of this uncertainty.



/s/ Ernst & Young LLP



Palo Alto,
California

January 30, 2003



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InSite Vision Incorporated



Consolidated Balance Sheets



|                                                                                                                                                                            |  |              |          |   |      |   |          |  
|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ------------ | -------- | - | ---- | - | -------- | -
|                                                                                                                                                                            |  | December 31, |         
|(in thousands, except share and per share amounts)                                                                                                                          |  | 2003         |          |   | 2002 |  
|Assets                                                                                                                                                                      |  |              |          |  
|Current assets:                                                                                                                                                             |  |              |          |   |      |   |          |  
|Cash and cash equivalents                                                                                                                                                   |  | $            | 1,045    |   |      | $ | 1,179    |  
|Inventory                                                                                                                                                                   |  |              | 19       |   |      |   | 19       |  
|Prepaid expenses and other current assets                                                                                                                                   |  |              | 91       |   |      |   | 124      |  
|                                                                                                                                                                            |  |              |          |   |      |   |          |  
|Total current assets                                                                                                                                                        |  |              | 1,155    |   |      |   | 1,322    |  
|                                                                                                                                                                            |  |              |          |   |      |   |          |  
|Property and equipment, at cost:                                                                                                                                            |  |              |          |   |      |   |          |  
|Laboratory and other equipment                                                                                                                                              |  |              | 837      |   |      |   | 1,087    |  
|Leasehold improvements                                                                                                                                                      |  |              | 73       |   |      |   | 73       |  
|Furniture and fixtures                                                                                                                                                      |  |              | 3        |   |      |   | 3        |  
|                                                                                                                                                                            |  |              |          |   |      |   |          |  
|                                                                                                                                                                            |  |              | 913      |   |      |   | 1,163    |  
|Accumulated depreciation                                                                                                                                                    |  |              | 664      |   |      |   | 619      |  
|                                                                                                                                                                            |  |              |          |   |      |   |          |  
|                                                                                                                                                                            |  |              | 249      |   |      |   | 544      |  
|                                                                                                                                                                            |  |              |          |   |      |   |          |  
|Deferred debt issuance cost                                                                                                                                                 |  |              | 1        |   |      |   |         |  
|                                                                                                                                                                            |  |              |          |   |      |   |          |  
|Total assets                                                                                                                                                                |  | $            | 1,405    |   |      | $ | 1,866    |  
|                                                                                                                                                                            |  |              |          |   |      |   |          |  
|Liabilities and stockholders equity (deficit)                                                                                                                              |  |              |          |  
|Current liabilities:                                                                                                                                                        |  |              |          |   |      |   |          |  
|Short-term notes payable to related parties, unsecured                                                                                                                      |  | $            | 326      |   |      | $ |         |  
|Short-term notes payable to related parties, secured                                                                                                                        |  |              | 682      |   |      |   |         |  
|Accounts payable                                                                                                                                                            |  |              | 972      |   |      |   | 373      |  
|Accrued liabilities                                                                                                                                                         |  |              | 650      |   |      |   | 307      |  
|Accrued compensation and related expense                                                                                                                                    |  |              | 160      |   |      |   | 289      |  
|Deferred revenue                                                                                                                                                            |  |              | 4,616    |   |      |   |         |  
|Deferred rent                                                                                                                                                               |  |              | 183      |   |      |   |         |  
|                                                                                                                                                                            |  |              |          |   |      |   |          |  
|Total current liabilities                                                                                                                                                   |  |              | 7,589    |   |      |   | 969      |  
|                                                                                                                                                                            |  |              |          |   |      |   |          |  
|Capital lease obligation, less current portion                                                                                                                              |  |              |         |   |      |   | 10       |  
|Convertible note payable (net of beneficial conversion feature of $1)                                                                                                       |  |              | 16       |   |      |   |         |  
|                                                                                                                                                                            |  |              |          |   |      |   |          |  
|Total liabilities                                                                                                                                                           |  |              | 7,605    |   |      |   | 979      |  
|                                                                                                                                                                            |  |              |          |   |      |   |          |  
|Commitments (Note 4)                                                                                                                                                        |  |              |          |   |      |   |          |  
|Stockholders equity (deficit)                                                                                                                                               |  |              |          |   |      |   |          |  
|Preferred stock, $0.01 par value, 5,000,000 shares authorized; none issued and outstanding at December 31, 2003; 2,000 issued and outstanding at December 31, 2002          |  |              |         |   |      |   | 2,048    |  
|                                                                                                                                                                            |  |              |          |   |      |   |          |  
|Common stockholders equity:                                                                                                                                                |  |              |          |   |      |   |          |  
|Common stock, $0.01 par value, 60,000,000 shares authorized; 29,253,294 issued and outstanding at December 31, 2003; 25,131,786 issued and
outstanding at December 31, 2002 |  |              | 293      |   |      |   | 251      |  
|Additional paid-in capital                                                                                                                                                  |  |              | 109,437  |   |      |   | 107,569  |  
|Notes receivable from stockholder                                                                                                                                           |  |              | (208     | ) |      |   | (231     | )
|Accumulated deficit                                                                                                                                                         |  |              | (115,722 | ) |      |   | (108,750 | )
|                                                                                                                                                                            |  |              |          |   |      |   |          |  
|Common stockholders deficit                                                                                                                                                |  |              | (6,200   | ) |      |   | (1,161   | )
|                                                                                                                                                                            |  |              |          |   |      |   |          |  
|Total stockholders (deficit) equity                                                                                                                                        |  |              | (6,200   | ) |      |   | 887      |  
|                                                                                                                                                                            |  |              |          |   |      |   |          |  
|Total liabilities and stockholders (deficit) equity                                                                                                                        |  | $            | 1,405    |   |      | $ | 1,866    |  
|                                                                                                                                                                            |  |              |          |   |      |   |          |  



See accompanying
notes to consolidated financial statements.



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InSite Vision Incorporated

Consolidated Statements of Operations



|                                                                                                |  |                         |        |   |      |   |         |      |  |   |         |  
|----------------------------------------------------------------------------------------------- |  | ----------------------- | ------ | - | ---- | - | ------- | ---- |  | - | ------- | -
|                                                                                                |  | Year Ended December 31, |       
|(in thousands, except per share amounts)                                                        |  | 2003                    |        |   | 2002 |   |         | 2001 | 
|Contract and other revenues                                                                     |  | $                       | 134    |   |      | $ | 36      |      |  | $ | 5       |  
|Cost of goods                                                                                   |  |                         | 20     |   |      |   | 114     |      |  |   |        |  
|                                                                                                |  |                         |        |   |      |   |         |      |  |   |         |  
|Gross profit                                                                                    |  |                         | 114    |   |      |   | (78     | )    |  |   | 5       |  
|                                                                                                |  |                         |        |   |      |   |         |      |  |   |         |  
|Operating expenses:                                                                             |  |                         |        |   |      |   |         |      |  |   |         |  
|Research and development                                                                        |  |                         | 4,436  |   |      |   | 7,077   |      |  |   | 7,323   |  
|Cost reimbursement                                                                              |  |                         |       |   |      |   | 166     |      |  |   | 713     |  
|                                                                                                |  |                         |        |   |      |   |         |      |  |   |         |  
|Research and development, net                                                                   |  |                         | 4,436  |   |      |   | 6,911   |      |  |   | 6,610   |  
|Selling, general and administrative                                                             |  |                         | 3,021  |   |      |   | 4,022   |      |  |   | 3,523   |  
|                                                                                                |  |                         |        |   |      |   |         |      |  |   |         |  
|Total                                                                                           |  |                         | 7,457  |   |      |   | 10,933  |      |  |   | 10,133  |  
|                                                                                                |  |                         |        |   |      |   |         |      |  |   |         |  
|Loss from operations                                                                            |  |                         | (7,343 | ) |      |   | (11,011 | )    |  |   | (10,128 | )
|                                                                                                |  |                         |        |   |      |   |         |      |  |   |         |  
|Gain on sale of assets                                                                          |  |                         | 1,153  |   |      |   |        |      |  |   |        |  
|Interest (expense) and other income, net                                                        |  |                         | (561   | ) |      |   | 62      |      |  |   | 572     |  
|                                                                                                |  |                         |        |   |      |   |         |      |  |   |         |  
|Net loss                                                                                        |  |                         | (6,751 | ) |      |   | (10,949 | )    |  |   | (9,556  | )
|Non-cash preferred stock dividend                                                               |  |                         | 221    |   |      |   | 48      |      |  |   |        |  
|                                                                                                |  |                         |        |   |      |   |         |      |  |   |         |  
|Net loss applicable to common stockholders                                                      |  | $                       | (6,972 | ) |      | $ | (10,997 | )    |  | $ | (9,556  | )
|                                                                                                |  |                         |        |   |      |   |         |      |  |   |         |  
|Net loss per share applicable to common stockholders, basic and diluted                         |  | $                       | (0.27  | ) |      | $ | (0.44   | )    |  | $ | (0.38   | )
|                                                                                                |  |                         |        |   |      |   |         |      |  |   |         |  
|Shares used to calculate basic and diluted net loss per share applicable to common stockholders |  |                         | 25,767 |   |      |   | 24,997  |      |  |   | 24,897  |  
|                                                                                                |  |                         |        |   |      |   |         |      |  |   |         |  



See accompanying
notes to consolidated financial statements.







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InSite Vision Incorporated



Consolidated Statements of Stockholders Equity (deficit)



|                                                                                                     |  |                |        |   |             |   |                          |  |                               |         |  |                    |      |   |                                   |   |          |   |  |   |         |  
|---------------------------------------------------------------------------------------------------- |  | -------------- | ------ | - | ----------- | - | ------------------------ |  | ----------------------------- | ------- |  | ------------------ | ---- | - | --------------------------------- | - | -------- | - |  | - | ------- | -
|(dollars in thousands)                                                                               |  | PreferredStock |        |   | CommonStock |   | AdditionalPaid InCapital |  | NoteReceivableFromStockholder |         |  | AccumulatedDeficit |      |   | TotalStockholdersEquity(deficit) |  
|Balances, January 1, 2001                                                                            |  | $              |       |   |             | $ | 248                      |  | $                             | 106,976 |  | $                  | (257 | ) |                                   | $ | (88,197  | ) |  | $ | 18,770  |  
|Issuance of 76,583 shares of common stock from exercise of options and employee stock purchase plan  |  |                |       |   |             |   | 1                        |  |                               | 70      |  |                    |     |   |                                   |   |         |   |  |   | 71      |  
|Non-employee stock option compensation                                                               |  |                |       |   |             |   |                         |  |                               | 200     |  |                    |     |   |                                   |   |         |   |  |   | 200     |  
|Net loss and comprehensive loss                                                                      |  |                |       |   |             |   |                         |  |                               |        |  |                    |     |   |                                   |   | (9,556   | ) |  |   | (9,556  | )
|                                                                                                     |  |                |        |   |             |   |                          |  |                               |         |  |                    |      |   |                                   |   |          |   |  |   |         |  
|Balances, December 31, 2001                                                                          |  | $              |       |   |             | $ | 249                      |  | $                             | 107,246 |  | $                  | (257 | ) |                                   | $ | (97,753  | ) |  | $ | 9,485   |  
|Issuance of 201,436 shares of common stock from exercise of options and employee stock purchase plan |  |                |       |   |             |   | 2                        |  |                               | 123     |  |                    |     |   |                                   |   |         |   |  |   | 125     |  
|Issuance of 2,000 shares of Series A-1 preferred stock                                               |  |                | 2,000  |   |             |   |                         |  |                               |        |  |                    |     |   |                                   |   |         |   |  |   | 2,000   |  
|Loan payment from stockholder                                                                        |  |                |       |   |             |   |                         |  |                               |        |  |                    | 26   |   |                                   |   |         |   |  |   | 26      |  
|Non-employee stock option and warrant compensation                                                   |  |                |       |   |             |   |                         |  |                               | 200     |  |                    |     |   |                                   |   |         |   |  |   | 200     |  
|Net loss and comprehensive loss                                                                      |  |                |       |   |             |   |                         |  |                               |        |  |                    |     |   |                                   |   | (10,949  | ) |  |   | (10,949 | )
|Non-cash preferred dividend                                                                          |  |                | 48     |   |             |   |                         |  |                               |        |  |                    |     |   |                                   |   | (48      | ) |  |   |        |  
|                                                                                                     |  |                |        |   |             |   |                          |  |                               |         |  |                    |      |   |                                   |   |          |   |  |   |         |  
|Net loss applicable to common stockholders                                                           |  |                | 48     |   |             |   |                         |  |                               |        |  |                    |     |   |                                   |   | (10,997  | ) |  |   | (10,949 | )
|                                                                                                     |  |                |        |   |             |   |                          |  |                               |         |  |                    |      |   |                                   |   |          |   |  |   |         |  
|Balances, December 31, 2002                                                                          |  | $              | 2,048  |   |             | $ | 251                      |  | $                             | 107,569 |  | $                  | (231 | ) |                                   | $ | (108,750 | ) |  | $ | 887     |  
|Issuance of 5,000 shares of common stock from exercise of options                                    |  |                |       |   |             |   |                         |  |                               | 3       |  |                    |     |   |                                   |   |         |   |  |   | 3       |  
|Issuance of 2,000 shares of Series A-1 preferred stock                                               |  |                | 2,000  |   |             |   |                         |  |                               |        |  |                    |     |   |                                   |   |         |   |  |   | 2,000   |  
|Issuance of 352,857 shares of common stock from private placements                                   |  |                |       |   |             |   | 4                        |  |                               | 130     |  |                    |     |   |                                   |   |         |   |  |   | 134     |  
|Issuance of convertible notes payable with beneficial conversion feature                             |  |                |       |   |             |   |                         |  |                               | 547     |  |                    |     |   |                                   |   |         |   |  |   | 547     |  
|Issuance of 3,763,651 share of common stock from conversion of debentures                            |  |                |       |   |             |   | 38                       |  |                               | 946     |  |                    |     |   |                                   |   |         |   |  |   | 984     |  
|Surrender of Series A-1 preferred stock as part of sale of assets                                    |  |                | (4,269 | ) |             |   |                         |  |                               |        |  |                    |     |   |                                   |   |         |   |  |   | (4,269  | )
|Loan payment from stockholder                                                                        |  |                |       |   |             |   |                         |  |                               |        |  |                    | 23   |   |                                   |   |         |   |  |   | 23      |  
|Non-employee stock option and warrant compensation                                                   |  |                |       |   |             |   |                         |  |                               | 242     |  |                    |     |   |                                   |   |         |   |  |   | 242     |  
|Net loss and comprehensive loss                                                                      |  |                |       |   |             |   |                         |  |                               |        |  |                    |     |   |                                   |   | (6,751   | ) |  |   | (6,751  | )
|Non-cash preferred dividend                                                                          |  |                | 221    |   |             |   |                         |  |                               |        |  |                    |     |   |                                   |   | (221     | ) |  |   |        |  
|                                                                                                     |  |                |        |   |             |   |                          |  |                               |         |  |                    |      |   |                                   |   |          |   |  |   |         |  
|Net loss applicable to common stockholders                                                           |  |                | 221    |   |             |   |                         |  |                               |        |  |                    |     |   |                                   |   | (6,972   | ) |  |   | (6,751  | )
|                                                                                                     |  |                |        |   |             |   |                          |  |                               |         |  |                    |      |   |                                   |   |          |   |  |   |         |  
|Balances, December 31, 2003                                                                          |  | $              |       |   |             | $ | 293                      |  | $                             | 109,437 |  | $                  | (208 | ) |                                   | $ | (115,722 | ) |  | $ | (6,200  | )
|                                                                                                     |  |                |        |   |             |   |                          |  |                               |         |  |                    |      |   |                                   |   |          |   |  |   |         |  



See accompanying
notes to consolidated financial statements.





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InSite Vision Incorporated



Consolidated Statements of Cash Flows



|                                                                                                                   |  |                         |        |   |      |   |         |      |  |   |        |  
|------------------------------------------------------------------------------------------------------------------ |  | ----------------------- | ------ | - | ---- | - | ------- | ---- |  | - | ------ | -
|                                                                                                                   |  | Year Ended December 31, |       
|(in thousands)                                                                                                     |  | 2003                    |        |   | 2002 |   |         | 2001 | 
|Operating activities:                                                                                              |  |                         |        |   |      |   |         |      |  |   |        |  
|Net loss                                                                                                           |  | $                       | (6,751 | ) |      | $ | (10,949 | )    |  | $ | (9,556 | )
|Adjustments to reconcile net loss to net cash used in operating activities:                                        |  |                         |        |   |      |   |         |      |  |   |        |  
|Depreciation and amortization                                                                                      |  |                         | 275    |   |      |   | 300     |      |  |   | 233    |  
|Stock-based compensation                                                                                           |  |                         | 242    |   |      |   | 200     |      |  |   | 200    |  
|Loss on disposal of capital lease asset                                                                            |  |                         | 27     |   |      |   |        |      |  |   |       |  
|Gain on sale of asset                                                                                              |  |                         | (1,153 | ) |      |   |        |      |  |   |       |  
|Amortization of beneficial conversion feature                                                                      |  |                         | 546    |   |      |   |        |      |  |   |       |  
|Debt issuance cost amortization                                                                                    |  |                         | 153    |   |      |   |        |      |  |   |       |  
|Accrued interest on convertible notes payable                                                                      |  |                         | 2      |   |      |   |        |      |  |   |       |  
|Changes in:                                                                                                        |  |                         |        |   |      |   |         |      |  |   |        |  
|Inventories, prepaid expenses and other current assets                                                             |  |                         | 33     |   |      |   | 30      |      |  |   | 432    |  
|Accounts payable, accrued liabilities accrued compensation and related expense deferred revenue, and deferred rent |  |                         | 1,031  |   |      |   | (556    | )    |  |   | 292    |  
|                                                                                                                   |  |                         |        |   |      |   |         |      |  |   |        |  
|Net cash used in operating activities                                                                              |  |                         | (5,595 | ) |      |   | (10,975 | )    |  |   | (8,399 | )
|Investing activities:                                                                                              |  |                         |        |   |      |   |         |      |  |   |        |  
|Purchases of property and equipment                                                                                |  |                         | (23    | ) |      |   | (61     | )    |  |   | (474   | )
|Proceeds from sale of asset                                                                                        |  |                         | 1,500  |   |      |   |        |      |  |   |       |  
|                                                                                                                   |  |                         |        |   |      |   |         |      |  |   |        |  
|Net cash provided by (used in) investing activities                                                                |  |                         | 1,477  |   |      |   | (61     | )    |  |   | (474   | )
|                                                                                                                   |  |                         |        |   |      |   |         |      |  |   |        |  
|Financing activities:                                                                                              |  |                         |        |   |      |   |         |      |  |   |        |  
|Payment of capital lease obligation                                                                                |  |                         | (18    | ) |      |   | (31     | )    |  |   | (7     | )
|Note payment received from stockholder                                                                             |  |                         | 23     |   |      |   | 26      |      |  |   |       |  
|Issuance of short-term notes payable to related parties                                                            |  |                         | 997    |   |      |   |        |      |  |   |       |  
|Issuance of convertible notes payable, net of issuance costs                                                       |  |                         | 845    |   |      |   |        |      |  |   |       |  
|Issuance of preferred stock                                                                                        |  |                         | 2,000  |   |      |   | 2,000   |      |  |   |       |  
|Issuance of common stock, net                                                                                      |  |                         | 137    |   |      |   | 125     |      |  |   | 71     |  
|                                                                                                                   |  |                         |        |   |      |   |         |      |  |   |        |  
|Net cash provided by financing activities                                                                          |  |                         | 3,984  |   |      |   | 2,120   |      |  |   | 64     |  
|                                                                                                                   |  |                         |        |   |      |   |         |      |  |   |        |  
|Net decrease in cash and cash equivalents                                                                          |  |                         | (134   | ) |      |   | (8,916  | )    |  |   | (8,809 | )
|Cash and cash equivalents, beginning of year                                                                       |  |                         | 1,179  |   |      |   | 10,095  |      |  |   | 18,904 |  
|                                                                                                                   |  |                         |        |   |      |   |         |      |  |   |        |  
|Cash and cash equivalents, end of year                                                                             |  | $                       | 1,045  |   |      | $ | 1,179   |      |  | $ | 10,095 |  
|                                                                                                                   |  |                         |        |   |      |   |         |      |  |   |        |  
|Supplemental disclosures:                                                                                          |  |                         |        |   |      |   |         |      |  |   |        |  
|Surrender of preferred stock in connection with sale of asset                                                      |  | $                       | 4,269  |   |      | $ |        |      |  | $ |       |  
|                                                                                                                   |  |                         |        |   |      |   |         |      |  |   |        |  
|Preferred stock dividends                                                                                          |  | $                       | 221    |   |      | $ | 48      |      |  | $ |       |  
|                                                                                                                   |  |                         |        |   |      |   |         |      |  |   |        |  
|Conversion of debentures to common stock                                                                           |  | $                       | 984    |   |      | $ |        |      |  | $ |       |  
|                                                                                                                   |  |                         |        |   |      |   |         |      |  |   |        |  
|Beneficial conversion feature on convertible notes payable                                                         |  | $                       | 547    |   |      | $ |        |      |  | $ |       |  
|                                                                                                                   |  |                         |        |   |      |   |         |      |  |   |        |  
|Capital lease obligation incurred                                                                                  |  | $                       |       |   |      | $ |        |      |  | $ | 51     |  
|                                                                                                                   |  |                         |        |   |      |   |         |      |  |   |        |  



See accompanying
notes to consolidated financial statements.



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InSite Vision Incorporated



Notes to Consolidated Financial Statements

December 31, 2003



|1. | Summary of Significant Accounting Policies
|-- | ------------------------------------------



Basis of Presentation. The accompanying consolidated financial statements include the accounts of InSite Vision, Ophthalmic Solutions, Inc., its
wholly-owned subsidiary and its wholly-owned United Kingdom subsidiary, InSite Vision Limited. InSite Vision Incorporated (the Company or InSite Vision) operated in one segment and is focused on ophthalmic genetics and
developing ophthalmic drugs and ophthalmic drug delivery systems. InSite Vision Limited was formed for the purpose of holding and licensing intellectual property rights. All intercompany accounts and transactions have been eliminated.



The Companys consolidated financial statements have been presented on a
basis that contemplates the realization of assets and the satisfaction of liabilities in the normal course of business and assumes the Company will continue as a going concern. Except for 1999, the Company has incurred losses since its inception,
including a net loss of $7.0 million for the year ended December 31, 2003, and the Company expects to incur substantial additional development costs, including costs related to clinical trials and manufacturing expenses. The Company has incurred
negative cash flows from operations since inception, including net cash used in operations of $4.1 million for the year ended December 31, 2003. As of December 31, 2003, the Company had an accumulated deficit of $115.7 million and a cash and cash
equivalents balance of $1.0 million. In these circumstances the Company believes it may not have enough cash to meet its various cash needs for fiscal 2004 unless the Company is able to obtain stockholder approval for the issuance of additional
shares related to the private placement it entered into in March 2004 (see Note 12 Subsequent Events). The Companys plans in this regard, include active pursuit of stockholder approval for the final closing of the private placement it entered
into in March 2004 and active pursuit of other sources of additional funds, including new license and collaboration agreements. There is no assurance that stockholder approval will be obtained or additional funds or license or collaborative
agreements will be available for the Company to finance its operations on acceptable terms, if at all. If such funds are not available, management will be required to delay, scale back or eliminate one or more of its research, discovery or
development programs and may cease operations altogether. Such actions may include significantly reducing its anticipated level of expenditures and/or the sale of rights to certain of its technologies, product candidates or products. The financial
statements do not include any adjustments to reflect the possible future effects on the recoverability and classification of assets or the amounts and classification of liabilities that may result from the outcome of this uncertainty.



The Company has continued a number of measures it took in 2003 to reduce its
short term operating expenses to allow it to continue operations without additional financing through approximately the beginning of June 2004. The measures taken in 2003 included: laying-off approximately 42% of its employees, voluntary salary
reductions by its senior management team, ceasing work on all non-critical external activities, extending payment terms on its trade payables, and other cost containment measures. There is no assurance that these expense reduction efforts will
enable the Company to continue operations or that if the Company does survive it has not significantly harmed its business or prospects.



Any person considering an investment in the Companys securities is urged to consider both the risk that the Company will cease operations at or
around the middle of June 2004 if stockholder approval is not obtained related to the proposed financing transaction or an alternative source of funds is not obtained. All of the statements set forth in this report are qualified by reference to
those facts.



Accounting Policies and Use of Estimates



The preparation of financial statements in conformity with generally
accepted accounting principles in the United States of America requires us to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. Actual results could differ from those estimates.



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The following are items in our financial statements that require significant estimates and judgments:



Inventory. Our inventories are stated at the lower of
cost or market. The cost of the inventory is based on the first-in first-out method. If the cost of the inventory exceeds the expected market value a provision is recorded for the difference between cost and market. At December 31, 2003, our
inventories solely consisted of OcuGene kits.



Property and Equipment. Property and equipment is stated at cost, less accumulated depreciation and amortization. Depreciation of property and equipment is provided over the estimated useful lives of the respective assets, which
range from three to five years, using the straight-line method. Leasehold improvements are amortized over the lives of the related leases or their estimated useful lives, whichever is shorter, using the straight-line method. It is our policy to
write-off our fully depreciated assets.



Additionally, we
record impairment losses on long-lived assets used in operations when events and circumstances indicate that the assets might be impaired and the undiscounted cash flows estimated to be generated by those assets are less than the carrying amounts of
those assets.



Revenue Recognition. We recognize
up-front fees over the expected term of the related research and development services using the straight-line method. When changes in the expected term of ongoing services are identified, the amortization period for the remaining fees is
appropriately modified.



Revenue related to performance
milestones is recognized when the milestone is achieved based on the terms set forth in the related agreements.



Revenue related to contract research services is recognized when the services are provided and collectibility is reasonable assured.



We directly reduced expenses for amounts reimbursed due to cost sharing
agreements during the year ended December 31, 2002 and 2001. We recognize the received cost sharing payments when persuasive evidence of an arrangement exists, the services have been rendered, the fee is fixed or determinable and collectibility is
reasonably assured. During the year ended 2003, we recognized cost reimbursements as contract and other revenue in accordance with EITF 01-14, Income Statement Characterization of Reimbursement for Out of Pocket expenses Incurred.



We receive royalties from licensees based on third-party sales
and the royalties are recorded as earned in accordance with contract terms, when third party results are reliably measured and collectibility is reasonably assured.



Revenue related to the sales of our product, the OcuGene glaucoma genetic test, is recognized when all
related services have been rendered and collectibility is reasonably assured. The revenue in connection with the asset purchase agreement with Bausch & Lomb will be recognized over the contract period.



Cost of goods. We recognize the cost of inventory shipped and other
costs related to our OcuGene glaucoma genetic test when they are incurred.



Research and Development (R&D) Expenses. R&D expenses include salaries, benefits, facility costs, services provided by outside consultants and contractors, administrative costs and materials for our
research and development activities. We also fund research at a variety of academic institutions based on agreements that are generally cancelable. We recognize such costs as they are incurred.



Selling, General and Administrative (SG&A) Expenses. SG&A
expenses include salaries, benefits, facility costs, services provided by outside consultants and contractors, advertising and marketing, investor relations, financial reporting, materials and other expenses related to general corporate and sales
and marketing activities.



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Stock-Based Compensation. We have elected to continue to follow the intrinsic value method of
accounting as prescribed by Accounting Principles Board Opinion No. 25 (or APB 25), Accounting for Stock Issued to Employees, to account for employee and director stock options. Accordingly, we do not recognize compensation expense for
options granted to employees and directors at an exercise price equal to the fair value of the underlying common stock.



Pro forma information regarding net loss and loss per share is required by Statement of Financial Accounting Standards (SFAS) No. 123, Accounting
for Stock Based Compensation, as amended by SFAS No. 148, and has been determined as if we had accounted for our employee stock options under the fair value method of that Statement. The fair value for these options was estimated at the date
of grant using a Black-Scholes option pricing model with the following weighted-average assumptions for 2003, 2002 and 2001, respectively: risk-free interest rates ranging from 0.89% to 5.57%; volatility factors for the expected market price of our
common stock of 1.06, 1.07 and 1.09; and a weighted-average expected life for the options of 4 years.



The following table illustrates the effect on net loss and net loss per share as if the Company had applied the fair value recognition provisions of SFAS
123 as amended by SFAS 148 to stock based employee compensation (in thousands, except per share amounts):



|                                                                                                          |  |                         |        |   |      |   |         |      |  |   |         |  
|--------------------------------------------------------------------------------------------------------- |  | ----------------------- | ------ | - | ---- | - | ------- | ---- |  | - | ------- | -
|                                                                                                          |  | Year Ended December 31, |       
|                                                                                                          |  | 2003                    |        |   | 2002 |   |         | 2002 | 
|Net loss applicable to common stockholders-as reported                                                    |  | $                       | (6,972 | ) |      | $ | (10,997 | )    |  | $ | (9,556  | )
|Deduct: Total stock-based employee compensation expense determined under fair value method for all awards |  |                         | (72    | ) |      |   | (184    | )    |  |   | (644    | )
|                                                                                                          |  |                         |        |   |      |   |         |      |  |   |         |  
|Net loss applicable to common stockholders-pro forma                                                      |  | $                       | (7,044 | ) |      | $ | (11,181 | )    |  | $ | (10,200 | )
|                                                                                                          |  |                         |        |   |      |   |         |      |  |   |         |  
|Loss applicable to common stockholders per share:                                                         |  |                         |        |   |      |   |         |      |  |   |         |  
|Basic and diluted-as reported                                                                             |  | $                       | (0.27  | ) |      | $ | (0.44   | )    |  | $ | (0.38   | )
|                                                                                                          |  |                         |        |   |      |   |         |      |  |   |         |  
|Basic and diluted-pro forma                                                                               |  | $                       | (0.27  | ) |      | $ | (0.45   | )    |  | $ | (0.41   | )
|                                                                                                          |  |                         |        |   |      |   |         |      |  |   |         |  



For purposes of pro
forma disclosures pursuant to SFAS 123 as amended by SFAS 148, the estimated fair value of options is amortized to expense over the options vesting period.



The pro forma impact of options on the net loss for 2003, 2002 and 2001 is not necessarily representative of the effects on
net income (loss) for future years, as future years will include the effects of additional stock grants.



Accounting for Stock Options and Warrants Exchanged for Services. The Company issues stock options and warrants to consultants of the Company in
exchange for services. The Company has valued these options and warrants using the Black-Scholes option pricing model in accordance with the Emerging Issues Task Force (EITF) Consensus No. 96-18, Accounting for Equity Investments that are
Issued to Other Than Employees for Acquiring or in Conjunction with Selling Goods, or Services, at each reporting period and has recorded charges to operations over the vesting periods of the individual stock options or warrant. Such charges
amounted to approximately $242,000, $200,000 and $200,000 in 2003, 2002 and 2001, respectively.



Income (Loss) per Share. Basic and diluted net income (loss) per share information for all periods is presented under the requirement of SFAS No.
128, Earnings per Share. Basic earnings per share has been computed using the weighted-average number of common shares outstanding during the period. Dilutive earnings per share is computed using the sum of the weighted-average number of
common shares outstanding and the potential number of dilutive common shares outstanding during the period. Potential common shares consist of the shares issuable upon exercise of stock options, warrants and convertible securities. Potentially
dilutive securities have been



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excluded from the computation of diluted net loss per share in 2003, 2002 and 2001 as their inclusion would be antidilutive.



The following table sets forth the computation of basic and diluted earnings
(loss) per share:



|                                                                                              |  |      |        |   |      |   |         |      |  |   |        |  
|--------------------------------------------------------------------------------------------- |  | ---- | ------ | - | ---- | - | ------- | ---- |  | - | ------ | -
|(in thousands, except per share amounts)                                                      |  | 2003 |        |   | 2002 |   |         | 2001 | 
|Numerator:                                                                                    |  |      |        |   |      |   |         |      |  |   |        |  
|Net loss                                                                                      |  | $    | (6,751 | ) |      | $ | (10,949 | )    |  | $ | (9,556 | )
|Non-cash preferred stock dividend                                                             |  |      | (221   | ) |      |   | (48     | )    |  |   |       |  
|                                                                                              |  |      |        |   |      |   |         |      |  |   |        |  
|Net loss applicable to common stockholders                                                    |  | $    | (6,972 | ) |      | $ | (10,997 | )    |  | $ | (9,556 | )
|                                                                                              |  |      |        |   |      |   |         |      |  |   |        |  
|Denominator:                                                                                  |  |      |        |   |      |   |         |      |  |   |        |  
|Denominator for basic and diluted loss per share - weighted-average common shares outstanding |  |      | 25,767 |   |      |   | 24,997  |      |  |   | 24,897 |  
|                                                                                              |  |      |        |   |      |   |         |      |  |   |        |  
|Basic and diluted net loss per share                                                          |  | $    | (0.27  | ) |      | $ | (0.44   | )    |  | $ | (0.38  | )
|                                                                                              |  |      |        |   |      |   |         |      |  |   |        |  



Due to the loss
applicable to common stockholders, loss per share for 2003, 2002 and 2001 is based on the weighted average number of common shares only, as the effect of including equivalent shares from stock options would be anti-dilutive. If the Company had
recorded net income, the calculation of earnings per share would have been impacted by the dilutive effect of the convertible notes payable in 2003, and the Series A-1 Preferred Shares in 2002, but would not have been effected by the minimal number
of outstanding stock options and warrants priced below the market price of the common shares at December 31, 2003. At December 31, 2003, 2002 and 2001, 156,000, 0 and 737,000 options and warrants were excluded from the calculation of diluted
earnings per share because the effect was anti-dilutive.



Accounting for Materials Purchased for Research and Development. The Company expenses materials for research and development activities when the obligation for the items is incurred.



Key Suppliers. The Company is dependent on single or limited source
suppliers for certain materials used in its research and development activities. The Company has generally been able to obtain adequate supplies of these components. However, an extended interruption in the supply of these components currently
obtained from single or limited source suppliers could adversely affect the Companys research and development efforts.



Income Taxes We account for income taxes under an asset and liability approach that requires the recognition of deferred tax assets and liabilities
for the expected future tax consequences of events that have been recognized in our financial statements or our tax returns. In estimating future tax consequences, we generally consider all expected future events other than enactments and changes in
the tax law or rates. A deferred tax valuation allowance is provided for deferred tax assets when it is determined that it is more likely than not that amounts will not be recovered.



Concentration of Risk. Financial instruments that potentially subject us to significant concentrations of credit risk
consist principally of cash and cash equivalents. Our cash and cash equivalents are primarily deposited in demand accounts with one financial institution.



Recent Accounting Pronouncements. In January 2003, the Financial Accounting Standards Board (FASB) issued Interpretation No. 46
(FIN 46), Consolidation of Variable Interest Entities, an Interpretation of ARB No. 51. FIN 46 requires certain variable interest entities to be consolidated by the primary beneficiary of the entity if the equity investors in
the entity do not have the characteristics of a controlling financial interest or do not have sufficient equity at risk for the entity to finance its activities without additional subordinated financial support from other parties. FIN 46 is
effective immediately for all new variable interest entities created or acquired after January 31, 2003. For variable interest entities created or acquired prior to February 1, 2003, the provisions of FIN 46 must be applied for the first interim or
annual period beginning after December 15, 2003. We will adopt FIN 46



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effective January 1, 2004. The adoption of FIN 46 is not expected to have a material impact on our financial position, results of operation or cash flows.



In May 2003, the FASB issued Statement of Financial Accounting
Standards No. 150 (SFAS 150), Accounting for Certain Financial Instruments with Characteristics of both Liabilities and Equity. SFAS 150 establishes standards for how an issuer classifies and measures certain financial
instruments with characteristics of both liabilities and equity. It requires that an issuer classify a financial instrument that is within its scope as a liability (or an asset in certain circumstances). Many of these instruments were previously
classified as equity. Although some of the provisions of this statement are consistent with the current definition of liabilities in FASB Concepts Statement No. 6, Elements of Financial Statements, the remainder is consistent with
FASBs intention to revise that definition to encompass certain obligations that a reporting entity can or must settle by issuing its own shares. This statement is effective for financial instruments entered into or modified after May 31, 2003
and otherwise is effective at the beginning of the first interim period beginning after June 15, 2003. There was no impact to the consolidated financial statements related to SFAS 150 for the year ended December 31, 2003.



|2. | Sale of Assets and Licenses
|-- | ---------------------------



In December 2003, the Company entered into agreements with Bausch & Lomb Incorporated, or Bausch & Lomb, in which the Company sold the assets
related to its ISV-403 product candidate, for the treatment of ocular bacterial infections, and licensed certain DuraSite patents for use in the ISV-403 product candidate. Bausch & Lomb made a payment to the Company of $1.5 million, surrendered
4,000 shares of Series A-1 Preferred Stock (See Note 7) and the related accumulated dividends, and will pay the Company royalties on future sales, if any. The Company had no carrying value related to the ISV-403 assets as all costs of development
were expensed as incurred. Additionally, the Company agreed to provide certain contracted services to Bausch & Lomb for a period beginning in November 2003 through April 2004, for which the Company would be paid an additional amount. The license
and stock purchase agreements the Company entered into with Bausch & Lomb related to the ISV-403 product candidate in August 2002 were terminated.



In accordance with Staff Accounting Bulletin No. 104, Revenue Recognition in Financial Statements, the Company is recognizing the $5.8 million of
revenue, representing the cash received of $1.5 million and the value of the Series A-1 Preferred Stock surrendered of $4.3 million, on a straight-line basis over the period for which contract services will be provided. Correspondingly, as of
December 31, 2003 the Company recognized $1.2 million of revenue from the sale of assets and recorded deferred revenue of $4.6 million.



In December 2002, the Company entered into an eight year distribution agreement with Societa Industria Farmaceutica Italiana  S.p.A. of Italy
(SIFI), in which InSite granted SIFI the exclusive right in Italy to perform, market and sell the OcuGene glaucoma genetic test and to manufacture and distribute the related patient sampling kits. SIFI will pay the Company
a royalty on each OcuGene test performed by them or on their behalf, if any.



In November 2002, the Company extended its November 2001 agreement with Quest Diagnostics Incorporated to provide laboratory services in the U.S. for the Companys recently introduced OcuGene
genetic test for the early prognosis and diagnosis of glaucoma. The Company will pay Quest a fee for each test performed and royalties on product sales.



In August 2002, the Company entered into a license agreement and preferred stock purchase agreement with Bausch & Lomb, in which InSite granted Bausch
& Lomb a royalty-bearing license to the Companys product candidate ISV-403 for the treatment of ocular bacterial infections. Bausch & Lomb obtained the right to market ISV-403 in all geographies except Japan, with such rights being
shared in Asia (except Japan) and exclusive elsewhere. The Company is responsible for the clinical development of ISV-403 through New Drug Application, or NDA, approval from the U.S. Food and Drug Administration, or FDA, with Bausch & Lomb
responsible for subsequent commercial manufacturing and marketing. Bausch & Lomb made an initial investment in preferred stock of $2.0 million in August 2002. Bausch & Lomb made a second investment in preferred stock of $2.0 million in
February 2003 when the Company reached the first milestone contemplated in the agreement. Upon the sale of these assets to Bausch & Lomb in December 2003, the license agreement and preferred stock purchase agreement were terminated and no future
milestone payments by Bausch & Lomb are required. (See Note 7.)





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In January 2002, the Company entered into an exclusive worldwide license agreement with the University of
Connecticut Health Center for the diagnostic, prognostic and therapeutic uses of a gene and its mutations for normal tension glaucoma. The Company paid a licensing fee and will make a milestone and royalty payments on future product sales, if any.



In April 2001, the Company signed a licensing agreement with
SSP Co., Ltd. of Tokyo, Japan (SSP), for two fourth generation fluoroquinolones, which have indicated increased sensitivity against gram positive and negative bacteria. The Company has exclusive rights to any products developed using
these compounds, with the exception of Japan, where SSP will retain the rights and the rest of Asia, where the Company will share joint rights with SSP. One of the compounds, SS734, is currently under development under the designation ISV-403.



|3. | Short-term Notes Payable
|-- | ------------------------



In August, September and November 2003, the Company issued a total of $188,000 in a series of short-term unsecured notes payable to members of the Board
of Directors, senior management and other employees of the Company for cash. These notes bear interest at a rate of two percent (2%) and are due March 31, 2004.



In July and August 2003, the Company issued $500,000 in short-term Senior Secured Notes payable to an officer who is also a member of the Board of
Directors and an affiliate of a member of senior management for cash. In November 2003 the Company increased one of the short-term Senior Secured Notes by $20,000 after receipt of cash. These notes bear interest at a rate of between five and
one-half percent (5.5%) and twelve percent (12%), were due between September 30, 2003 and October 15, 2003 and are secured by a lien on substantially all of the assets of the Company, including the Companys intellectual property, other than
the equipment secured under the Senior Secured Notes issued in May 2003, described below, and certain other equipment secured by the lessor of such equipment. Prior to September 30, 2003 the due dates of these notes were extended to between November
15, 2003 and December 31, 2003. Subsequently, the due dates were further extended to January 15, 2004 and March 31, 2004. In January 2004, the Company repaid $120,000 of these Senior Secured Notes and the related accrued interest. The Company had
$682,000 of short-term secured notes payable to related parties outstanding at December 31, 2003.



In May and June 2003, the Company issued a series of short-term notes payable totaling $288,500 to members of the Board of Directors, senior management
and other stockholders for cash. $100,000 of these notes are Senior Secured Notes, bear a two percent (2%) annual interest rate, were due September 28, 2003 and are secured by a lien on certain pieces of laboratory and other equipment. Prior to
September 28, 2003 the due date on these notes was extended to December 31, 2003. Subsequently, the due dates were further extended to January 15, 2004. In January 2004, these Senior Secured Notes and the related accrued interest were repaid by the
Company. The remainder of these notes are unsecured, bear interest rates between two percent (2%) and twelve percent (12%) and were due August 15, 2003. On August 15, 2003, the due date on these notes was extended to November 15, 2003. Prior to
November 15, 2003 the due date on these notes was extended to December 15, 2003. Subsequently, the due date on these notes was extended to March 31, 2004. The Company had $326,000 of unsecured notes payable to related parties outstanding at December
31, 2003.



|4. | Lease Commitments
|-- | -----------------



The Company leases its facilities under non-cancelable operating lease agreements that expire in 2006. Rent expense was $697,000, $659,000, and $445,000
for 2003, 2002 and 2001, respectively. The 2002 and 2001 rent expense reflects $13,000 and $74,000, respectively, received by the Company related to the January 1999 sublease of a portion of the Companys facility. The sublease ended in
February 2002.



Capital lease obligations represent the present
value of future rental payments under capital lease agreement for laboratory equipment. The original cost and accumulated amortization on the equipment under capital leases are $39,900 and $39,900, respectively, at December 31, 2003 and $103,600 and
$44,500, respectively, at December 31, 2002.



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Future minimum payments under capital and operating leases are as follows:



|                                                 |  |                |  |                  |          
|------------------------------------------------ |  | -------------- |  | ---------------- | ---------
|Year ending December 31,                         |  | Capital Leases |  | Operating Leases
|2004                                             |  | 9,528          |  |                  | 718,113  
|2005                                             |  |               |  |                  | 743,253  
|2006                                             |  |               |  |                  | 769,245  
|                                                 |  |                |  |                  |          
|Total minimum lease payments                     |  | 9,528          |  | $                | 2,230,611
|                                                 |  |                |  |                  |          
|Amount representing interest                     |  | 524            |  |                  |          
|                                                 |  |                |  |                  |          
|Present value of net minimum lease payments      |  | 9,004          |  |                  |          
|Current portion, included in accrued liabilities |  | 9,004          |  |                  |          
|                                                 |  |                |  |                  |          
|Long-term portion                                |  | 0              |  |                  |          
|                                                 |  |                |  |                  |          



|5. | Convertible Notes Payable
|-- | -------------------------



On September 22, 2003, the Company, Arrow Acquisition, Inc., a wholly-owned subsidiary of the Company, and Ophthalmic Solutions, Inc., (Ophthalmic
Solutions) entered into an Agreement and Plan of Merger (the Merger Agreement). The merger contemplated by the Merger Agreement (the Merger) was also completed on September 22, 2003. As a result of the Merger,
Ophthalmic Solutions became a wholly-owned subsidiary of the Company and all outstanding shares of Ophthalmic Solutions capital stock held by its sole stockholder were converted into 100 shares of the Companys common stock. Ophthalmic
Solutions is a private, development stage company with a business plan to pursue opportunities for over-the-counter products in the area of ophthalmology and had immaterial assets and liabilities as of September 22, 2003, other than its obligations
under and the proceeds from the debentures described below.



Immediately prior to the Merger, Ophthalmic Solutions entered into a Convertible Debenture Purchase Agreement (the Purchase Agreement), dated as of September 22, 2003, with HEM Mutual Assurance LLC, pursuant to which it sold and
issued convertible debentures to HEM in an aggregate principal amount of up to $1,000,000 in a private placement pursuant to Rule 504 of Regulation D under the Securities Act of 1933, as amended. Two debentures in the aggregate principal amount of
$500,000 were issued for gross proceeds of $500,000 in cash (the Initial Debentures) and an additional debenture in the aggregate principal amount of $500,000 (the Contingent Debenture and collectively with the Initial
Debentures, the Debentures) was issued in exchange for a promissory note from HEM in the principal amount of $500,000 (the Note). Each of the Debentures had a maturity date of September 21, 2008, subject to earlier conversion
or redemption pursuant to its terms, and bears interest at the rate of 1% per year, payable in cash or shares of common stock at the option of the holder of the Debentures. As a result of the Merger, the Company has assumed the rights and
obligations of Ophthalmic Solutions in the private placement, including the gross proceeds raised through the sale of the Debentures, the Note issued by HEM to Ophthalmic Solutions, and Ophthalmic Solutions obligations under the Debentures and
the Purchase Agreement.



As a result of the Merger at September
22, 2003, $492,750 and $3,625 in principal amount of the Initial Debentures was convertible into unrestricted shares of the Companys common stock at a conversion price that is the lower of $0.30 or the average of the three lowest closing per
share bid prices for the common stock during the 40 trading days prior to conversion and $0.01 per share, respectively. On November 12, 2003 the $500,000 Contingent Debenture and an additional $3,625 of Initial Debentures became convertible and
subject to repayment when the related Note from HEM was paid in full to the Company in cash. The Contingent Debenture is convertible into unrestricted shares of the Companys common stock at a conversion price that is the lower of $0.375 or the
average of the three lowest closing per share bid prices for the common stock during the 40 trading days prior to conversion and the additional Initial Debentures have a conversion price of $0.01 per share.



The merger has been accounted for as an acquisition of assets. The assets
acquired and liabilities assumed include: convertible debentures, cash and the related promissory note(s). Ophthalmic Solutions had no other assets



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or liabilities at the time of the merger. This asset acquisition has been, in substance, reflected as a financing transaction in the accompanying financial
statements, including the receipt of cash and the issuance of debentures.



The Initial Debenture conversion prices of $0.30 and $0.01 per share, respectively were lower than the per share price of the Companys common stock on the issuance date of September 22, 2003. The conversion
prices of the Contingent Debenture and remaining Initial Debentures of $0.375 and $0.01 per share, respectively were lower than the per share price of the Companys common stock on November 12, 2003 when the related Note from HEM was paid in
full to the Company in cash. In accordance with the provisions of EITF 00-27, Accounting for Convertible Securities with Beneficial Conversion Features or Contingently Adjustable Conversion Ratios to Certain Convertible Instruments, the
Company recorded a beneficial conversion feature of $547,000 related to the debentures. The Company accretes the $547,000 discount recorded from the beneficial conversion feature from the dates the debentures became convertible, September 22, 2003
and November 12, 2003, to the stated redemption date of September 21, 2008. The accretion has been reported as interest expense with a corresponding increase to convertible debentures. Further, as amounts are converted into common stock, prior to
the redemption date, all of the remaining unamortized discount associated with those shares will be immediately recognized as interest expense. As of December 31, 2003 approximately $546,000 of the beneficial conversion feature had been expensed as
interest. As of December 31, 2003, the $16,000 convertible debentures reported on the face of the balance sheet are net of related unamortized debt discount of $1,000. In connection with the convertible debt financing, the Company capitalized
approximately $154,000 of debt issuance costs, which are included in prepaid expenses and other current assets and other assets. These costs are being amortized over the life of the convertible debentures. As of December 31, 2003, $1,000 of the debt
financing costs remain and $153,000 has been amortized.



On
December 19, 2003, $482,329 in debenture principal and the related interest was converted into 1,393,011 shares of the Companys common stock. On December 11, 2003, $3,625 in debenture principal and the related interest was converted into
363,284 shares of the Companys common stock. On November 26, 2003, $92,750 in debenture principal and the related interest was converted into 309,717 shares of the Companys common stock. On November 10, 2003, $200,000 in debenture
principal and the related interest was converted into 667,561 shares of the Companys common stock. On October 30, 2003, $200,000 in debenture principal and the related interest was converted into 667,360 shares of the Companys common
stock. On October 15, 2003, $3,625 debenture principal and the related interest was converted into 362,718 shares of the Companys common stock.



The conversion price and number of shares of common stock issuable upon conversion of the Debentures is subject to adjustment for stock splits and
combinations and other dilutive events. To satisfy its conversion obligations under the Debentures, the Company placed 5,000,000 shares of its common stock into escrow for potential issuance to HEM upon conversion of the Debentures. As of December
31, 2003, 1,236,348 shares of common stock remain in escrow. Unless and until the debentures are converted, HEM has no voting or other ownership rights in any of the shares of our common stock held in escrow and the shares in escrow are not treated
by the Company as being issued and outstanding.



The Debentures
may never be converted into an aggregate of more than 5,000,000 shares of the Companys common stock unless the Company elects to increase the number of shares held in escrow in accordance with and subject to any applicable rules or regulations
of The American Stock Exchange or such other exchange, market or system on which the Companys common stock is then listed requiring stockholder approval prior to such additional issuance. In the event that the conversion rate of the Debentures
would require the Company to issue more than an aggregate of 5,000,000 shares of the Companys common stock upon conversion of the Debentures and the Company elects not to increase the number of shares held in escrow (or the Company fails to
obtain any required stockholder approval for such proposed increase), the Company will be required to redeem the unconverted amount of the Debentures for 140% of the principal amount thereof, plus accrued and unpaid interest.



In addition to the foregoing, the Debentures may not be converted if and to
the extent that after such conversion the holder would beneficially own more than 5% of the Companys then outstanding common stock, unless the holder waives this limitation by providing the Company 75 days prior notice of the waiver.



The Company has the right to redeem the Debentures, in whole
or in part, at any time on 30 days advanced notice for 140% of the principal amount of the outstanding Debentures being redeemed, plus accrued and unpaid



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interest. In addition, if at any time any of the Debentures are outstanding, the Company receives debt or equity financing in an amount equal to or exceeding
Five Million dollars ($5,000,000) in a single transaction or series of related transactions (excluding any portion of such financing consisting of forgiveness of debt or other obligations), the Company is required to redeem the Debentures for 150%
of the amount of the then outstanding Debentures. If trading in our common stock is suspended (other than suspensions of trading on such market or exchange generally or temporary suspensions pending the release of material information) for more than
ten trading days, or if our common stock is delisted from the exchange, market or system on which it is then traded and not relisted on another exchange, market or the Over the Counter Bulletin Board within 10 trading days, HEM may elect to require
us to redeem all then outstanding Debentures and any shares of our common stock held by HEM through prior conversions at a price equal to the sum of the aggregate market value of the common stock then held by HEM through prior conversions plus the
value of all unconverted Debentures then held by HEM, calculated in each case in the manner set forth in the Purchase Agreement. The Company would owe an interest penalty of 8% per year on any payments not made within 7 business days of a redemption
request made pursuant to the preceding sentence.



Pursuant to
the Purchase Agreement, until December 22, 2003, the Company was prohibited from offering or issuing any floorless convertible security or any equity line of credit, although the Company could have entered into any other debt or equity financing
during such period. In addition, HEM had the right to participate in any debt or equity financing offered by us during the 30-day period following December 22, 2003.



Until such time as it no longer holds any Debentures, neither HEM nor its affiliates may engage in any short sales of the
Companys common stock if there is no offsetting long position in the Companys common stock then held by HEM or such affiliates.



|6. | Income Taxes
|-- | ------------



Due to the companys history of net operating losses, there is no provision for income taxes for the years ended December 31, 2003, 2002 and 2001.



Significant components of the Companys deferred tax
assets for federal and state income taxes as of December 31, 2003 and 2002 are as follows (in thousands):



|                                     |  |      |         |   |      |   |         |  
|------------------------------------ |  | ---- | ------- | - | ---- | - | ------- | -
|                                     |  | 2003 |         |   | 2002 |  
|Deferred tax assets:                 |  |      |         |   |      |   |         |  
|Net operating loss carryforwards     |  | $    | 32,054  |   |      | $ | 30,732  |  
|Tax credit carryforwards             |  |      | 5,970   |   |      |   | 5,378   |  
|Capitalized research and development |  |      | 7,549   |   |      |   | 9,166   |  
|Deferred revenue                     |  |      | 1,846   |   |      |   |        |  
|Depreciation                         |  |      | 434     |   |      |   | 440     |  
|Other                                |  |      | 58      |   |      |   | 127     |  
|                                     |  |      |         |   |      |   |         |  
|Total deferred tax assets            |  |      | 47,911  |   |      |   | 45,843  |  
|Valuation allowance                  |  |      | (47,911 | ) |      |   | (45,843 | )
|                                     |  |      |         |   |      |   |         |  
|Net deferred tax assets              |  | $    |        |   |      | $ |        |  
|                                     |  |      |         |   |      |   |         |  



The valuation
allowance increased by $2.1 million, $4.2 million and $4.2 million during the years ended December 31, 2003, 2002 and 2001, respectively.



At December 31, 2003, the Company has net operating loss carryforwards for federal income tax purposes of approximately $85.5 million, which expire in the
years 2004 through 2023 and federal tax credits of approximately $3.3 million, which expire in the years 2004 through 2023. The Company also has net operating loss carryforwards for state income tax purposes of approximately $49.6 million which
expire in the years 2004 through 2015, and state research and development tax credits of approximately and $2.5 million which carryforward indefinitely.



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Utilization of the Companys federal and state net operating loss carryforwards and research and
development tax credits are subject to an annual limitation against taxable income in future periods due to the ownership change limitations provided by the Internal Revenue Code of 1986. As a result of this annual limitation, a significant portion
of these carryforwards will expire before ultimately becoming available for offset against taxable income. Additional losses and credits will be subject to limitation if the Company incurs another change in ownership in the future.



|7. | Preferred Stock
|-- | ---------------



Series A-1 Preferred Stock



In August 2002, the Company entered into a Preferred Stock Purchase Agreement with Bausch & Lomb contemporaneously with the execution of the Bausch
& Lomb License Agreement for the ISV-403 product candidate. The Stock Purchase Agreement provides for Bausch & Lomb to purchase up to 15,000 shares of Series A-1 Preferred Stock for a purchase price equal to $1,000 per share for an aggregate
investment of up to $15.0 million. The initial investment, which was made in August 2002, was for 2,000 shares of Series A-1 Preferred Stock, for a total investment equal to $2.0 million. In February 2003, the first milestone was reached and Bausch
& Lomb invested an additional $2.0 million and received 2,000 more shares of Series A-1 Preferred Stock. In December 2003, the ISV-403 product candidate was sold to Bausch & Lomb and the Preferred Stock Purchase Agreement was terminated and
the 4,000 outstanding shares, and the related accumulated dividends, were surrendered to the Company. The Series A-1 Preferred Stock did not contain voting rights, except as otherwise provided by the Delaware General Corporation law and each share
of Series A-1 Preferred Stock was entitled to a 6% per annum cumulative dividend.



For the year ended December 31, 2003 and 2002, the Company reported non-cash preferred dividends of $221,000 and $48,000, respectively. The dividends are related to the 6% per annum premium earned on the outstanding
Series A-1 Preferred Stock and are taken into consideration to determine the net loss per share applicable to common stockholders.



|8. | Common Stockholders Equity (Deficit)
|-- | -------------------------------------



On December 16, 2003, the Company entered into a private placement of 142,857 shares of its common stock to an accredited investor and received $50,000 in
net proceeds. On October 20, 2003, the Company entered into a private placement of 210,000 shares of its common stock to two accredited investors and received $84,000 in net proceeds. During 2003 the Company received $3,000 from the exercise of
stock options.



In December 2003, the Company issued warrants
to purchase 250,000 shares of common stock for $0.58 per share that expire in December 2006 to Xmark as part of the settlement of a legal suit which were expensed during the year(See Note 10). In November 2003, the Company issued warrants to
purchase 125,000 shares of common stock for $0.40 that expire in November 2008 to a financial advisor as part of the placement of convertible notes payable. In September 2003, the Company issued warrants to purchase 81,967 shares of common stock for
$0.61 until September 2008 to a financial advisor as part of the initial placement of convertible notes payable. In August 2003, the company issued warrants to a financial advisor to purchase 50,000 shares of common stock for $0.50 per share that
expire in August 2006. These warrants were valued using a Black-Scholes option pricing model, assuming no dividend yield, with the following assumptions: risk-free interest rate of 4.44%, volatility of 1.0616 and an expected life of 5, 3 and 3
years, respectively, resulting in the recording of an expense of $180,000 for the year ended December 31, 2003. As of December 31, 2003, all of these warrants were outstanding.



In April 2002, the Company issued warrants to purchase 20,000 shares of common stock for $2.33 per share that expire in
April 2006 to a financial advisor. In February 2002, the Company issued warrants to purchase 38,000 shares of Common Stock for $2.20 per share that expire in February 2005 to a financial advisor. These warrants were valued using a Black-Scholes
option pricing model, assuming no dividend yield, with the following assumptions: risk-free interest rate of 4.76%, volatility of 1.1361 and an expected life of 4 and 3 years, respectively,



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resulting in the recording of an expense of $85,000 for the year ended December 31, 2002. As of December 31, 2003, all of these warrants were outstanding.



In February 2001, the Company filed a shelf registration for
the issuance of up to $40.0 million of common stock or securities convertible into or exercisable into the Companys common stock. The common stock, if issued, will be sold through a placement agent. As of December 31, 2003 no shares had been
issued under this shelf registration and it was not available due to the market capitalization of the Company.



Stock Option Plan



At December 31, 2003, a total of 3,974,653 shares of common stock were reserved under the 1994 Stock Plan for issuance upon the exercise of options or by
direct sale to employees, including officers, directors and consultants. Options granted under the plan expire 10 years from the date of grant and become exercisable at such times and under such conditions as determined by the Companys Board
of Directors (generally ratably over four years, with the first 25% vesting after one year). Under the terms of the 1994 Stock Plan on automatic share increase feature pursuant to which the number of shares available for issuance is automatically
increased on the first trading day in January each calendar year, beginning with calendar year 2002 and continuing over the term of the Plan by an amount equal to 0.2% of the total number of shares of common stock outstanding on the last trading day
in December in the immediately proceeding calendar year. Activity under the 1994 Stock Plan is as follows:



|                              |  |                           |   |  |                    |   |  |             |             |                                                    |   |     
|----------------------------- |  | ------------------------- | - |  | ------------------ | - |  | ----------- | ----------- | -------------------------------------------------- | - | ----
|                              |  | Shares                   
|                              |  | OptionsAvailablefor Grant |   |  | OptionsOutstanding |   |  | OptionPrice |             | Weighted AverageExercise Price ofShares Under Plan
|Balances at January 1, 2001   |  | 787,996                   |   |  | 1,918,103          |   |  | $           | 0.60 -9.25  |                                                    | $ | 2.53
|Additional shares reserved    |  | 497,014                   |   |  |                    |   |  |             |             |                                                    |   |    
|Granted                       |  | (444,500                  | ) |  | 444,500            |   |  |             | 1.02 - 2.20 |                                                    |   | 1.52
|Exercised                     |  |                          |   |  | (40,406            | ) |  |             | 0.60 - 1.13 |                                                    |   | 0.66
|Forfeited                     |  | 35,443                    |   |  | (35,443            | ) |  |             | 1.45 - 5.88 |                                                    |   | 3.71
|                              |  |                           |   |  |                    |   |  |             |             |                                                    |   |     
|Balances at December 31, 2001 |  | 875,953                   |   |  | 2,286,754          |   |  |             | 0.60 - 9.25 |                                                    |   | 2.35
|Additional shares reserved    |  | 498,545                   |   |  |                    |   |  |             |             |                                                    |   |     
|Granted                       |  | (395,250                  | ) |  | 395,250            |   |  |             | 0.70 - 1.97 |                                                    |   | 0.93
|Exercised                     |  |                          |   |  | (184,173           | ) |  |             | 0.73 - 1.80 |                                                    |   | 0.96
|Forfeited                     |  | 20,616                    |   |  | (20,616            | ) |  |             | 0.60 - 4.81 |                                                    |   | 1.44
|                              |  |                           |   |  |                    |   |  |             |             |                                                    |   |     
|Balances at December 31, 2002 |  | 999,864                   |   |  | 2,477,215          |   |  |             | 0.60 - 9.25 |                                                    |   | 2.26
|Additional shares reserved    |  | 502,574                   |   |  |                    |   |  |             |             |                                                    |   |     
|Granted                       |  | (925,500                  | ) |  | 925,500            |   |  |             | 0.41- 0.85  |                                                    |   | 0.60
|Exercised                     |  |                          |   |  | (5,000             | ) |  |             | 0.70 - 0.70 |                                                    |   | 0.70
|Forfeited                     |  | 346,384                   |   |  | (346,384           | ) |  |             | 0.41- 9.25  |                                                    |   | 1.48
|                              |  |                           |   |  |                    |   |  |             |             |                                                    |   |     
|Balances at December 31, 2003 |  | 923,322                   |   |  | 3,051,331          |   |  | $           | 0.41 -6.38  |                                                    | $ | 1.85
|                              |  |                           |   |  |                    |   |  |             |             |                                                    |   |     



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The following table summarizes information concerning currently outstanding and exercisable options:



|                         |  |                     |  |                     |  |                    |      |                                |           |  |   |     
|------------------------ |  | ------------------- |  | ------------------- |  | ------------------ | ---- | ------------------------------ | --------- |  | - | ----
|                         |  | Options Outstanding |  | Options Exercisable
|                         |  |                     |  | Weighted Average    |  | Number Exercisable |      | Weighted Average ExercisePrice
|Range of Exercise Prices |  | Number Outstanding  |  | Contractual Life    |  | ExercisePrice      |      |                               
|$0.41 - $0.85            |  | 820,500             |  | 9.54                |  | $                  | 0.60 |                                | 405,488   |  | $ | 0.71
|$0.93 - $1.13            |  | 782,382             |  | 6.66                |  |                    | 1.04 |                                | 581,556   |  |   | 1.08
|$1.20 - $2.75            |  | 833,700             |  | 4.44                |  |                    | 2.10 |                                | 743,053   |  |   | 2.17
|$2.81 - $6.38            |  | 614,749             |  | 4.00                |  |                    | 4.19 |                                | 610,773   |  |   | 4.18
|                         |  |                     |  |                     |  |                    |      |                                |           |  |   |     
|                         |  | 3,051,331           |  | 6.30                |  | $                  | 1.85 |                                | 2,340,870 |  | $ | 2.17
|                         |  |                     |  |                     |  |                    |      |                                |           |  |   |     



The weighted average
grant date fair value of options granted during 2003, 2002 and 2001 was $0.56, $0.86 and $1.42 per share, respectively.



Pursuant to the terms of the 1994 Stock Plan, generally each non-employee director who is newly elected or appointed after October 25, 1993, is granted an
option to purchase 10,000 shares of common stock at a price per share equal to the fair market value of the common stock on the grant date. Each continuing non-employee director also receives an annual grant of an option to purchase 10,000 shares.
Such options vest one year after the grant date.



In June 2002,
the Companys stockholders approved a series of amendments to the Companys 1994 Stock Option Plan, or the 1994 Plan, including (i) increasing the maximum number of shares of common stock issuable to any one person under the 1994 Plan over
the term of the 1994 Plan by 400,000 shares so that the limit is increased from 850,000 shares to 1,250,000 shares and (ii) extending the term of the 1994 Plan by an additional 5 years so that the expiration date is extended from July 27, 2003 to
July 27, 2008.



The Company granted stock options to
non-employees which resulted in compensation expense of $62,000, $116,000 and $200,000 in 2003, 2002 and 2001, respectively.



Employee Stock Purchase Plan



On April 1, 1994, employees of the Company began participating in the 1994 Employee Stock Purchase Plan, or the Purchase Plan, which provides the
opportunity to purchase common stock at prices not more than 85% of market value at the time of purchase. In June 2000, the Companys stockholders approved an additional 85,000 shares of common stock be reserved for issuance under the Purchase
Plan. In June 2002, the Companys stockholders approved a series of amendments to the Companys Purchase Plan, including (i) increasing by 100,000 the total number of shares of the Companys common stock authorized for issuance under
the Purchase Plan, (ii) extending the term of the Purchase Plan by an additional 5 years so that the expiration date is extended from December 31, 2003 to December 31, 2008, and (iii) implementing an automatic share increase feature pursuant to
which the number of shares available for issuance under the Purchase Plan is automatically increased on the first trading day in January each calendar year, beginning with calendar year 2003 and continuing over the remaining term of the Purchase
Plan, as extended, by an amount equal to 0.5% of the total number of shares of common stock outstanding on the last trading day in December in the immediately preceding calendar year, but in no event will any such annual increase exceed 125,000
shares.



During the years ended December 31, 2003, 2002 and
2001, respectively, none, 37,122, and 45,759 shares of common stock were issued pursuant to this plan. At December 31, 2003, 225,007 additional shares were reserved for issuance under this plan. The effects of this plan on the pro forma disclosures
described in Note 1 are not material.



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The weighted average grant date fair value of the Purchase Plan shares issued during 2002 and 2001 was
$1.14 and $1.43 per share, respectively.



|9. | Notes Receivable from Stockholder
|-- | ---------------------------------



In May 2000, the Company issued loans to Dr. Chandrasekaran, the Companys President, Chief Executive Officer (CEO), Chief Financial Officer (CFO)
and Chairman of the Board, related to his exercise of 126,667 options to acquire common stock. In May 2001, the terms on the loans were extended from 4 years to 5 years. In 2003 and 2002, Dr. Chandrasekaran made principal and interest payments of
$38,500 and $83,000, respectively. The loans are full recourse and bear interest at 7% per annum. Interest payments are due semi-annually and principal payments are due annually. While the 126,667 shares of common stock issued secure the loans, the
Company is not limited to these shares to satisfy the loan.



|10. | Legal Proceedings
|--- | -----------------



On June 23, 2003 Xmark Funds, L.P. et al, or Xmark, filed a complaint in the United States District Court, Southern District of New York against the
Company alleging that the Company breached the terms of the term sheet signed between Xmark Funds and the Company in May 2003. On December 31, 2003 the Company settled the suit with Xmark. As part of the settlement, the Company paid Xmark $10,000
and issued Xmark fully vested warrants to purchase 250,000 shares of the Companys common stock at an exercise price of $0.58 per share. The warrants expire on December 31, 2006 subject to certain possible extensions. Legal fees related to this
litigation were expensed as incurred.



On or about October 8,
2003, a former consultant filed a complaint in the Superior Court of California, County of San Francisco, against the Company, our chief executive officer, Kumar Chandrasekaran, the Regents of the University of California or Regents, and
two individuals associated with Regents. The former consultant alleges that the Company breached an obligation to continue supporting his research; he has also made a variety of other related claims and allegations against the Company and the other
defendants. The complaint seeks both monetary and injunctive relief. The former consultant has filed a motion to enjoin the Company during the pendency of the litigation from alienating the license rights held by the Company relating to the subject
of the former consultants research, which was denied. The Company and Dr. Chandrasekaran filed a demurrer challenging certain aspects of the complaint, which was heard on January 28, 2004. The Court has not yet issued a ruling on the demurrer,
and until that ruling issues, the Company does not expect any further response to the complaint to be filed by either the Company or by Dr. Chandrasekaran. The outcome of this matter cannot be determined at this time and therefore no contingent
liabilities have been recorded.



From time to time, the Company
may be subject to legal proceedings and claims in the ordinary course of business, including claims of alleged infringement of trademarks and other intellectual property rights. The Company currently is not aware of any other legal proceedings or
claims that it believes will have, individually or in the aggregate, a material adverse effect on its business, prospects, financial condition and operating results.



|11. | Related Party
|--- | -------------



Included in accounts payable on the balance sheet is $116,000 due to related parties for expenses incurred on behalf of the Company.



|12. | Subsequent Event
|--- | ----------------



On March 26, 2004, the Company received approximately $1.8 million from the initial closing of a private placement totaling $16.5 million. At the initial
closing the Company issued 3,880,000 shares of Common Stock and warrants to purchase 1,940,000 shares of Common Stock at an exercise price of $0.75 per share. The final closing is contingent upon the Company receiving stockholder approval for the
financing and for an amendment to the Certificate of Incorporation increasing the authorized shares of Common Stock by 49,500,000, and other standard closing conditions. The Company will seek stockholder approval at its June 1, 2004 Annual Meeting.



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|13. | Quarterly Results (Unaudited)
|--- | -----------------------------



The following table is a summary of the quarterly results of operations for the years ended December 31, 2003 and 2002. The Company believes that the
following information reflects all normal recurring adjustments necessary for a fair presentation of the information for the periods presented. The operating results for any quarter are not necessarily indicative of results for any future period.





|                                                                                                |  |                                          |        |   |               |   |        |                   |  |   |                |   |  |            |        |   |  |   |         |  
|----------------------------------------------------------------------------------------------- |  | ---------------------------------------- | ------ | - | ------------- | - | ------ | ----------------- |  | - | -------------- | - |  | ---------- | ------ | - |  | - | ------- | -
|                                                                                                |  | (in thousands, except per share amounts) |       
|                                                                                                |  | FirstQuarter                             |        |   | SecondQuarter |   |        | 2003 ThirdQuarter |  |   | Fourth Quarter |   |  | Total Year |       
|Revenues                                                                                        |  | $                                        | 4      |   |               | $ | 1      |                   |  | $ | 4              |   |  | $          | 125    |   |  | $ | 134     |  
|Cost of goods                                                                                   |  |                                          | 8      |   |               |   | 4      |                   |  |   | 5              |   |  |            | 3      |   |  |   | 20      |  
|Loss from operations                                                                            |  |                                          | (2,276 | ) |               |   | (1,826 | )                 |  |   | (1,393         | ) |  |            | (1,848 | ) |  |   | (7,343  | )
|Net loss applicable to common stockholders                                                      |  |                                          | (2,314 | ) |               |   | (1,886 | )                 |  |   | (1,462         | ) |  |            | (1,310 | ) |  |   | (6,972  | )
|Basic and diluted net loss per share applicable to common stockholders                          |  | $                                        | (0.09  | ) |               | $ | (0.08  | )                 |  | $ | (0.06          | ) |  | $          | (0.05  | ) |  | $ | (0.27   | )
|Shares used to calculate basic and diluted net loss per share applicable to common stockholders |  |                                          | 25,133 |   |               |   | 25,137 |                   |  |   | 25,137         |   |  |            | 27,661 |   |  |   | 25,767  |  
|                                                                                                |  |                                          |        |   |               |   |        |                   |  |   |                |   |  |            |        |   |  |   |         |  
|                                                                                                |  |                                          |        |   |              
|                                                                                                |  | FirstQuarter                             |        |   | SecondQuarter |   |        | 2002 ThirdQuarter |  |   | Fourth Quarter |   |  | Total Year |       
|Revenues                                                                                        |  | $                                        | 9      |   |               | $ | 8      |                   |  | $ | 9              |   |  | $          | 10     |   |  | $ | 36      |  
|Cost of goods                                                                                   |  |                                          | 17     |   |               |   | 14     |                   |  |   | 25             |   |  |            | 58     |   |  |   | 114     |  
|Loss from operations                                                                            |  |                                          | (2,985 | ) |               |   | (2,646 | )                 |  |   | (3,100         | ) |  |            | (2,280 | ) |  |   | (11,011 | )
|Net loss                                                                                        |  |                                          | (2,957 | ) |               |   | (2,631 | )                 |  |   | (3,108         | ) |  |            | (2,301 | ) |  |   | (10,997 | )
|Basic and diluted net loss per share                                                            |  | $                                        | (0.12  | ) |               | $ | (0.11  | )                 |  | $ | (0.12          | ) |  | $          | (0.09  | ) |  | $ | (0.44   | )
|Shares used to calculate basic and diluted net loss per share                                   |  |                                          | 24,930 |   |               |   | 24,941 |                   |  |   | 25,007         |   |  |            | 25,109 |   |  |   | 24,997  |  
|                                                                                                |  |                                          |        |   |               |   |        |                   |  |   |                |   |  |            |        |   |  |   |         |  



|Item 9. | Changes in and Disagreements with Accountants on Accounting and Financial Disclosure
|------- | ------------------------------------------------------------------------------------



On October 21, 2003, Ernst & Young LLP notified us that it would resign as our independent public accountants following
the completion of its review of the Registrants Form 10-Q for the Quarter ended September 30, 2003. Our Audit Committee was informed of, but did not recommend or approve, Ernst & Youngs resignation.



Ernst & Youngs reports on the financial statements for the past two
fiscal years contained no adverse opinion or disclaimer of opinion and were not qualified or modified as to uncertainty, audit scope or accounting principle, except that Ernst & Youngs report on the financial statements for the year ended
December 31, 2002 contained an explanatory paragraph expressing substantial doubt about our ability to continue as a going concern.



During our two most recent fiscal years ended December 31, 2002 and the subsequent interim periods up to and including their resignation, there were no
disagreements between us and Ernst on any matter of accounting principles or practices, financial statement disclosure, or auditing scope or procedure, which disagreements, if not resolved to Ernst & Youngs satisfaction, would have caused
them to make reference to the subject matter of the disagreement in connection with their reports; and there were no reportable events as described in Item 304(a)(1)(v) of Regulation S-K.



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Ernst provided us a letter addressed to the SEC stating whether it agrees with the statements made above
by us. A copy of Ernst & Youngs letter dated October 28, 2003, has been filed with the SEC.



On February 19, 2004, we engaged Burr, Pilger & Mayer LLP as our new independent accountant. The decision to engage Burr, Pilger & Mayer LLP was
recommended and approved by our Audit Committee.



During the
two most recent fiscal years ended December 31, 2002 and December 31, 2003 and during the current fiscal year through the engagement of Burr, Pilger & Mayer LLP on February 19, 2004, we had not consulted with Burr, Pilger & Mayer LLP
regarding either the application of accounting principles to a specified transaction, either completed or proposed, or the type of audit opinion that might be rendered on our financial statements; nor on any matter that was either the subject of a
disagreement or a reportable event.



|Item 9A. | Controls and Procedures
|-------- | -----------------------



Under the supervision and with the participation of our management, including our principal executive officer and principal financial officer, we
conducted an evaluation of the effectiveness of the design and operation of our disclosure controls and procedures, as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended (the Exchange Act), as
of the end of the period covered by this report (the Evaluation Date). Based upon the evaluation, our principal executive officer and principal financial officer concluded as of the Evaluation Date that our disclosure controls and
procedures were effective to ensure that information required to be disclosed by us in reports that we file or submit under the Exchange Act (i) is recorded, processed, summarized and reported within the time periods specified in Securities and
Exchange Commission rules and forms, and (ii) is accumulated and communicated to our management, including our principal executive officer and principal financial officer, as appropriate to allow timely decisions regarding required disclosure.



PART III



|Item 10. | Directors and Executive Officers of the Registrant
|-------- | --------------------------------------------------



The information required by this item with respect to the identification of Directors is hereby incorporated by reference from the information under the
caption Election of Directors in the Companys Proxy Statement for its Annual Meeting of Stockholders which is expected to be held on June 1, 2004 (the Proxy Statement).



The information required by this item with respect to the identification of
Executive Officers is contained in Item 1 of Part I of this report under the caption Executive Officers.



The information required by this item regarding compliance with Section 16(a) of the Securities Exchange Act of 1934 is hereby incorporated by reference
from the information under the caption Compliance with Section 16(a) of the Securities Exchange Act of 1934 in the Proxy Statement.



The information required by this item regarding the audit committee of the board of directors and information regarding an audit committee financial
expert is incorporated by reference from information contained under the caption Board Committees and Meetings in the Proxy Statement.



The information required by this item regarding the Companys code of ethics that applies to the Companys principal executive officer,
principal financial officer and controller is incorporated by reference from information contained under the caption Board Committees and Meetings in the Proxy Statement.



Information regarding our implementation of procedures for stockholder nominations to our board of directors is incorporated
by reference from information contained under the caption Board Committees and Meetings in the Proxy Statement.



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|Item 11. | Executive Compensation
|-------- | ----------------------



The information required by this item is hereby incorporated by reference from the information under the caption Executive Compensation and Related
Information in the Proxy Statement.



|Item 12. | Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters
|-------- | ----------------------------------------------------------------------------------------------



The information required by this item is hereby incorporated by reference from the information under the captions
Principal Stockholders and Equity Compensation Plan Information in the Proxy Statement.



|Item 13. | Certain Relationships and Related Transactions
|-------- | ----------------------------------------------



The information required by this item is hereby incorporated by reference from the information under the captions Executive Compensation and Related
Information and Certain Relationships and Related Transactions in the Proxy Statement.



|Item 14. | Principal Accountant Fees and Services
|-------- | --------------------------------------



The information required by this item is incorporated by reference from the information contained under the caption Principal Accountant Fees and
Services in the Proxy Statement.



PART IV



|Item 15. | Exhibits, Financial Statement Schedules and Reports on Form 8-K
|-------- | ---------------------------------------------------------------



|(a)(1) | Financial Statements
|------ | --------------------



The Financial Statements and Report of Independent Auditors are included in a separate section of this Annual Report on Form 10-K. See index to
consolidated financial statements at Item 8 of this Annual Report on Form 10-K.



|(2) | Financial Statement Schedules
|--- | -----------------------------



All financial statement schedules have been omitted because they are not applicable or are not required or the required information to be set forth
therein is included in the Financial Statements or notes thereto included in a separate section of this Annual Report on Form 10-K. See index to consolidated financial statements at Item 8 of this Annual Report on Form 10-K.



|(3) | Exhibits
|--- | --------



See Exhibit Index on page 66 of this Annual Report on Form 10-K.



|(b) | Reports on Form 8-K
|--- | -------------------



On October 28, 2003, we filed a Current Report on Form 8-K reporting under Item 4 the resignation of our certifying accountant subsequent to the filing of
our quarterly report on Form 10-Q for the quarter ended September 30, 2003.



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On November 21, 2003, we filed an Amendment No. 1 to Current Report on Form 8-K/A reporting under Item 4
that the resignation of our certifying accountant was effective as of November 19, 2003.



|(c) | Exhibits
|--- | --------



See Exhibit Index on page 66 of this Annual Report on Form 10-K.



|(d) | Financial Statement Schedules
|--- | -----------------------------



See (a)(2) above.



SIGNATURES



Pursuant to the
requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.



Dated: March 30, 2004



INSITE VISION INCORPORATEDBy:

/s/    S. KUMAR CHANDRASEKARANS. Kumar Chandrasekaran, Ph.D. Chairman of the Board, President, Chief Executive Officer and Chief Financial Officer




Pursuant to the
requirements of the Securities Exchange Act of 1934, this report has been signed by the following persons on behalf of the Registrant and in the capacities and on the dates indicated.



|                                                               |  |                                                                                       |  |               
|-------------------------------------------------------------- |  | ------------------------------------------------------------------------------------- |  | --------------
|Name                                                           |  | Capacity                                                                              |  | Date          
|                                                               |  |                                                                                      
|/s/    S. KUMAR
CHANDRASEKARANS. Kumar
Chandrasekaran, Ph.D.   |  | Chairman of the Board, President, Chief Executive Officer and Chief Financial Officer |  | March 30, 2004
|                                                               |  |                                                                                      
|/s/    MITCHELL H.
FRIEDLAENDERMitchell H. Friedlaender,
M. D. |  | Director                                                                              |  | March 30, 2004
|                                                               |  |                                                                                      
|/s/    JOHN L.
MATTANAJohn L.
Mattana                          |  | Director                                                                              |  | March 30, 2004
|                                                               |  |                                                                                      
|/s/    JON S.
SAXEJon S. Saxe                                  |  | Director                                                                              |  | March 30, 2004
|                                                               |  |                                                                                      
|/s/    ANDERS P.
WIKLUNDAnders P.
Wiklund                      |  | Director                                                                              |  | March 30, 2004



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EXHIBIT INDEX



|        |  |                                                                                                                                                                                                                                        
|------- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Number  |  | Exhibit Table                                                                                                                                                                                                                          
|        | 
|2.1     |  | Agreement and Plan of Merger, dated as of September 22, 2003, by and among InSite Vision Incorporated, a Delaware corporation, Arrow Acquisition, Inc., a Delaware corporation, and Ophthalmic
Solutions, Inc., a Delaware corporation.
|        | 
|3.11    |  | Restated Certificate of Incorporation.                                                                                                                                                                                                 
|        | 
|3.29    |  | Certificate of Designations, Preferences and Rights of Series A Convertible Preferred Stock as filed with the Delaware Secretary of State on September 11, 1997.                                                                       
|        | 
|3.39    |  | Certificate of Correction of the Certificate of Designations, Preferences and Rights of Series A Convertible Preferred Stock as filed with the Delaware Secretary of State on September 26,
1997.                                      
|        | 
|3.415   |  | Certificate of Designations, Preferences and Rights of Series A-1 Preferred Stock as filed with the Delaware Secretary of State on July 3, 2002.                                                                                       
|        | 
|3.56    |  | Amended and Restated Bylaws.                                                                                                                                                                                                           
|        | 
|4.1     |  | Reference is made to Exhibits 3.1, 3.2, 3.3 and 3.4.                                                                                                                                                                                   
|        | 
|4.217   |  | Convertible Debenture Purchase Agreement, dated as of September 22, 2003, by and between Ophthalmic Solutions, Inc. and HEM Mutual Assurance LLC.                                                                                      
|        | 
|4.317   |  | $492,750 1% Convertible Debenture Due September 21, 2008, originally issued by Ophthalmic Solutions, Inc., a Delaware corporation to HEM Mutual Assurance LLC on September 22,
3003.                                                   
|        | 
|4.417   |  | $7,250 1% Convertible Debenture Due September 21, 2008, originally issued by Ophthalmic Solutions, Inc., a Delaware corporation to HEM Mutual Assurance LLC on September 22,
3003.                                                     
|        | 
|4.517   |  | $500,000 1% Convertible Debenture Due September 21, 2008, originally issued by Ophthalmic Solutions, Inc., a Delaware corporation to HEM Mutual Assurance LLC on September 22,
3003.                                                   
|        | 
|10.110  |  | InSite Vision Incorporated 1994 Employee Stock Purchase Plan (As amended and restated through April 17, 2000).                                                                                                                         
|        | 
|10.28HH |  | InSite Vision Incorporated 1994 Stock Option Plan (Amended and Restated as of June 8, 1998).                                                                                                                                           
|        | 
|10.31HH |  | Form of InSite Vision Incorporated Notice of Grant of Stock Option and Stock Option Agreement, with Addenda.                                                                                                                           
|        | 
|10.48HH |  | Form of InSite Vision Incorporated Notice of Automatic Option Grant and Non-Employee Director Option Agreement.                                                                                                                        
|        | 
|10.51   |  | InSite Vision Incorporated 1994 Employee Stock Purchase Plan.                                                                                                                                                                          
|        | 
|10.61   |  | Form of InSite Vision Incorporated Stock Purchase Agreement.                                                                                                                                                                           
|        | 
|10.71   |  | Form of InSite Vision Incorporated Employee Stock Purchase Plan Enrollment/Change Form.                                                                                                                                                
|        | 
|10.82   |  | Form of Indemnity Agreement Between the Registrant and its directors and officers.                                                                                                                                                     
|        | 
|10.92   |  | Form of Employees Proprietary Information and Inventions Agreement.                                                                                                                                                                   
|        | 
|10.103H |  | License Agreement dated as of October 9, 1991 by and between the Company and CIBA Vision Corporation, as amended October 9, 1991.                                                                                                      
|        | 
|10.113H |  | Letter Agreement dated February 27, 1992 by and among the Company, Columbia Laboratories, Inc. and Joseph R. Robinson, as amended October 23, 1992.                                                                                    
|        | 
|10.127  |  | Facilities Lease, dated September 1, 1996, between the Registrant and Alameda Real Estate Investments.                                                                                                                                 
|        | 
|10.134  |  | Common Stock Purchase Agreement dated January 19, 1996 between the Registrant and the Investors listed on Schedule 1 thereto.                                                                                                          



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|         |  |                                                                                                                                                                                                                                          
|-------- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Number   |  | Exhibit Table                                                                                                                                                                                                                            
|         | 
|10.145H  |  | ISV-205 License Agreement dated May 28, 1996 by and between the Company and CIBA Vision Ophthalmics.                                                                                                                                     
|         | 
|10.155H  |  | To PreSite License Agreement dated May 28, 1996 by and between the Company and CIBA Vision Ophthalmics.                                                                                                                                  
|         | 
|10.165H  |  | Timolol Development Agreement dated July 18, 1996 by and between the Company and Bausch & Lomb Pharmaceuticals, Inc.                                                                                                                     
|         | 
|10.175H  |  | Stock Purchase Agreement dated July 18, 1996 by and between the Company and Bausch & Lomb Pharmaceuticals, Inc.                                                                                                                          
|         | 
|10.189H  |  | License Agreement, dated July 1, 1997, by and between the University of Connecticut Health Center and the Company.                                                                                                                       
|         | 
|10.199H  |  | License Agreement, dated August 19, 1997, by and between the University of Rochester and the Company.                                                                                                                                    
|         | 
|10.2011  |  | Form of Stock and Warrant Purchase Agreement, dated May 1, 2000 by and among the Company and the purchasers thereto.                                                                                                                     
|         | 
|10.2112  |  | Placement Agent Agreement with Ladenburg Thalmann & Co., Inc. dated January 9, 2001.                                                                                                                                                     
|         | 
|10.2213  |  | Amendment No. 1 to Marina Village Office Tech Lease, dated July 20, 2001 and effective January 1, 2002.                                                                                                                                  
|         | 
|10.2314H |  | License Agreement, dated December 21, 2001 by and between the Company and The University of Connecticut Health Center.                                                                                                                   
|         | 
|10.2416  |  | Form of Senior Secured Notes in the aggregate principal amount of $100,000, each dated May 28, 2003, issued by the Company to the holders listed on the signature pages to the Equipment Lien
Agreement included as Exhibit 10.25 hereto.
|         | 
|10.2516  |  | Form of Equipment Lien Agreement, dated as of May 28, 2003, between the Company and the holders listed on the signature pages thereto.                                                                                                   
|         | 
|10.2616  |  | Form of Promissory Notes in the aggregate principal amount of $188,500, dated between June 13, 2003 and June 30, 2003, issued by the Company to certain members of the Companys Board of
Directors, senior management, and stockholders.
|         | 
|10.2716  |  | Form of Waiver and Amendment to Promissory Notes to Promissory Notes by and between the Company and the holders of the promissory Notes included as Exhibit 10.26 hereto.                                                                
|         | 
|10.2816  |  | Form of Senior Secured Note in the principal amount of $400,000, dated July 15, 2003, issued by the Company to S. Kumar Chandrasekaran, Ph.D.                                                                                            
|         | 
|10.2916  |  | Form of Senior Secured Note in the principal amount of $50,000, dated July 30, 2003, issued by the Company to MHU Ventures, Inc.                                                                                                         
|         | 
|10.3016  |  | Form of Security Agreement, dated as of July 15, 2003, between the Company and the holders listed on the signature pages thereto.                                                                                                        
|         | 
|10.3116  |  | Form of Amendment to July 15, 2003 Security Agreement, dated as of July 30, 2003, by and among the Company and the parties listed on the signature page thereto.                                                                         
|         | 
|10.3219H |  | ISV-403 Asset Purchase Agreement, dated December 19, 2003, between the Company and Bausch & Lomb, Inc.                                                                                                                                   
|         | 
|16.118   |  | Letter of Ernst & Young, LLP regarding change in certifying account, dated October 28, 2003.                                                                                                                                             
|         | 
|23.1     |  | Consent of Burr, Pilger & Mayer LLP, Independent Auditors.                                                                                                                                                                               
|         | 
|23.2     |  | Consent of Ernst & Young LLP, Independent Auditors.                                                                                                                                                                                      
|         | 
|31.1     |  | Certification of Chief Executive Officer pursuant to Rules 13a-14(a) and 15d-14(a) promulgated under the Securities Exchange Act of 1934, as amended.                                                                                    
|         | 
|31.2     |  | Certification of Chief Financial Officer pursuant to Rules 13a-14(a) and 15d-14(a) promulgated under the Securities Exchange Act of 1934, as amended.                                                                                    



67



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##### Table of Contents

|       |  |                                                                                                                                                                               
|------ |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Number |  | Exhibit Table                                                                                                                                                                 
|       | 
|32.1   |  | Certification of Chief Executive Officer and Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.



| | 1 | Incorporated by reference to an exhibit in the Companys Annual Report on Form 10-K for the year ended December 31, 1993.
| | - | -------------------------------------------------------------------------------------------------------------------------



| | 2 | Incorporated by reference to an exhibit in the Companys Registration Statement on Form S-1 (Registration No. 33-68024) as filed with the Securities and
Exchange Commission on August 27, 1993.
| | - | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 3 | Incorporated by reference to an exhibit in Amendment No. 1 the Companys Registration Statement on Form S-1 (Registration No. 33-68024) as filed with the
Securities and Exchange Commission on September 16, 1993.
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 4 | Incorporated by reference to an exhibit in the Companys Annual Report on Form 10-K for the year ended December 31, 1995.
| | - | -------------------------------------------------------------------------------------------------------------------------



| | 5 | Incorporated by reference to an exhibit in the Companys Quarterly Report on Form 10-Q for the quarter ended June 30, 1996.
| | - | ---------------------------------------------------------------------------------------------------------------------------

| | 
| | 

| | 6 | Incorporated by reference to an exhibit in the Companys Quarterly Report on Form 10-Q
for the quarter ended March 31, 1997.
| | - | ----------------------------------------------------------------------------------------------------------------------------



| | 7 | Incorporated by reference to an exhibit in the Companys Annual Report on Form 10-K for
the year ended December 31, 1996.
| | - | -------------------------------------------------------------------------------------------------------------------------



| | 8 | Incorporated by reference to exhibits in the Companys Registration Statement on Form
S-8 (Registration No. 333-60057) as filed with the Securities and Exchange Commission on July 28, 1998.
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 9 | Incorporated by reference to exhibits in the Companys Registration Statement on Form
S-3 (Registration No. 333-36673) as filed with the Securities and Exchange Commission on September 29, 1997.
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 10 | Incorporated by reference to an exhibit to the Companys Registration Statement on Form S-8 (Registration No. 333-43504) as filed with the Securities and
Exchange Commission on August 11, 2000.
| | -- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 11 | Incorporated by reference to an exhibit to the Companys Registration Statement on Form S-3 (Registration No. 333-38266) as filed with the Securities and
Exchange Commission on June 1, 2000.
| | -- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 12 | Incorporated by reference to an exhibit to the Companys Registration Statement on Form S-3 (Registration No. 333-54912) as filed with the Securities and
Exchange Commission on February 2, 2001.
| | -- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 13 | Incorporated by reference to an exhibit to the Companys Quarterly Report on Form 10-Q for the quarter ended September 30, 2001.
| | -- | --------------------------------------------------------------------------------------------------------------------------------



| | 14 | Incorporated by reference to an exhibit to the Companys Annual Report of Form 10-K for the year ended December 31, 2001.
| | -- | -------------------------------------------------------------------------------------------------------------------------



| | 15 | Incorporated by reference to an exhibit to the Companys Quarterly Report on Form 10-Q for the quarter ended September 30, 2002.
| | -- | --------------------------------------------------------------------------------------------------------------------------------



| | 16 | Incorporated by reference to an exhibit to the Companys Quarterly Report on Form 10-Q/A for the quarter ended June 30, 2003.
| | -- | -----------------------------------------------------------------------------------------------------------------------------



| | 17 | Incorporated by reference to an exhibit to the Companys Current Report on Form 8-K filed with the Securities and Exchange Commission on September 23, 2003.
| | -- | ------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 18 | Incorporated by reference to an exhibit to the Companys Current Report on Form 8-K filed with the Securities and Exchange Commission on October 28, 2003.
| | -- | ----------------------------------------------------------------------------------------------------------------------------------------------------------



| | 19 | Incorporated by reference to an exhibit to the Companys Current Report on Form 8-K filed with the Securities and Exchange Commission on January 14, 2004.
| | -- | ----------------------------------------------------------------------------------------------------------------------------------------------------------



| | H | Confidential treatment has been granted with respect to certain portions of this agreement.
| | - | -------------------------------------------------------------------------------------------



| | HH | Management contract or compensatory plan.
| | -- | -----------------------------------------



68