# Patent

## Title
Heterocyclic compounds and thrombopoietin receptor activators

## Abstract

A compound represented by the formula (1):




wherein A is a nitrogen atom or CR4, B is an oxygen atom, a sulfur atom or NR9 (provided that when A is a nitrogen atom, B is not NH), R1 is a C2-14 aryl group, L1 is a bond, CR10R11, an oxygen atom, a sulfur atom or NR12, X is OR13 SR13 or NR14NR15, R2 is a hydrogen atom, a formyl group, a C1-10 alkyl group or the like, L2 is a bond or the like, L3 is a bond, CR17R18, an oxygen atom, a sulfur atom or NR19, L4 is a bond, CR20R21, an oxygen atom, a sulfur atom or NR22, Y is an oxygen atom, a sulfur atom or NR23, and R3 is a C2-14 aryl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

## Background
This application is a continuation in part of PCT/JP2004/008165 filed on Jun. 4, 2004, and incorporated entirely herein by reference.


TECHNICAL FIELD
The present invention relates to preventive, therapeutic and improving agents having affinity for and agonistic action on the thrombopoietin receptor for diseases against which activation of the thrombopoietin receptor is effective. Specifically, it relates to pharmaceutical compositions comprising compounds which increase platelets through stimulation of differentiation and proliferation of hematopoietic stem cells, megakaryocytic progenitor cells and megakaryocytes or compounds for therapeutic angiogenesis or with anti-arteriosclerosis action that stimulate differentiation and proliferation of vascular endothelial cells and endothelial progenitor cells.
BACKGROUND ART
Thrombopoietin is a cytokine consisting of 332 amino acids that increases platelet production by stimulating differentiation and proliferation of hematopoietic stem cells, megakaryocytic progenitor cells and megakaryocytes mediated by its receptor and therefore is promising as a drug for hematological disorders. Recent reports that it stimulates differentiation and proliferation of vascular endothelial cells and endothelial progenitor cells have raised expectations of therapeutic angiogenesis, anti-arteriosclerosis and prevention of cardiovascular events (for example, non-patent document 1, non-patent document 2 and non-patent document 3).
Biologically active substances which have been known so far to regulate platelet production through the thrombopoietin receptor include, in addition to thrombopoietin itself, low molecular weight peptides having affinity for the thrombopoietin receptor (for example, patent document 1, patent document 2, patent document 3 and patent document 4).
As a result of search for nonpeptidic low molecular weight compounds that increase platelet production mediated by the thrombopoietin receptor, low molecular weight compounds having affinity for the thrombopoietin receptor have been reported (for example, patent document 5 to patent document 24).

    1) Applications filed by Hokuriku Seiyaku Co., Ltd. relating to 1,4-benzodiazepine derivatives (patent documents 5 and 6)
    2) International Laid-open Patent Applications filed by Shionogi & Co., Ltd. (patent documents 7-10)
    3) International Laid-open Patent Applications filed by SmithKline Beecham Corp (patent documents 11-19)
    4) Japanese Laid-open Patent Application filed by Torii Pharmaceutical Co., Ltd. (patent document 20)
    5) International Laid-open Patent Application filed by Roche Diagnostics GMBH (patent document 21)
    6) International Laid-open Patent Application filed by Yamanouchi Pharmaceutical Co., Ltd. (patent document 22 and 23)
    7) Japanese Laid-open Patent Application filed by Japan Tabacco Inc. (Patent document 24)


Patent document 1 JP-A-10-72492
Patent document 2 WO96/40750
Patent document 3 WO96/40189
Patent document 4 WO98/25965
Patent document 5 JP-A-11-1477
Patent document 6 JP-A-11-152276
Patent document 7 WO01/07423
Patent document 8 WO01/53267
Patent document 9 WO02/059099
Patent document 10 WO02/059100
Patent document 11 WO00/35446
Patent document 12 WO00/66112
Patent document 13 WO01/34585
Patent document 14 WO01/17349
Patent document 15 WO01/39773
Patent document 16 WO01/21180
Patent document 17 WO01/89457
Patent document 18 WO02/49413
Patent document 19 WO02/085343
Patent document 20 JP-A-2001-97948
Patent document 21 WO99/11262
Patent document 22 WO02/062775
Patent document 23 WO03/062233
Patent document 24 JP-A-2003-238565
Non-patent document 1 Microvasc. Res., 1999: 58, p.108-113
Non-patent document 2 Circ. Res., 1999: 84, p.785-796
Non-patent document 3 Blood 2001:98, p.71a-72a
DISCLOSURE OF THE INVENTION
Thrombopoietin and low molecular weight peptides having affinity for the thrombopoietin receptor are likely to be easily degraded in the gastrointestinal tract and are usually difficult to orally administer. As to thrombopoietin itself, the appearance of anti-thrombopoietin antibodies have been reported.
Besides, though it is probably possible to orally administer nonpeptidic low molecular weight compounds, no practical drugs have been put on the market.
Therefore, orally administrable low molecular weight compounds having excellent affinity for and agonistic action on the thrombopoietin receptor as preventive, therapeutic and improving agents for diseases against which activation of the thrombopoietin receptor is effective have been demanded. Specifically, low molecular weight compounds which can serve as platelet increasing agents or increasing agents for other blood cells by stimulating differentiation and proliferation of hematopoietic stem cells, megakaryocytic progenitor cells and megakaryocytes or low molecular weight compounds which can be used for therapeutic angiogenesis or as preventive and therapeutic agents for arteriosclerosis by stimulating endothelial cells and endothelial progenitor cells have been demanded.
The present inventors conducted extensive research to find low molecular weight compounds having affinity for and agonistic action on the thrombopoietin receptor, and as a result, found that the compounds of the present invention have high affinity and agonistic action which enable them to show potent platelet increasing action by stimulating differentiation and proliferation of megakaryocytic progenitor cells and megakaryocytes. The present invention was accomplished on the basis of this discovery.
Namely, the present invention relates to:

    1. A compound represented by the formula (1)






wherein A is a nitrogen atom or CR4 (wherein R4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C2-6 alkenyl group or a C2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a C1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2-6 alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group, a mono- or di-C1-10 alkylamino group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group, the mono- or di-C1-10 alkylamino group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), or R6 and R7 mean, together with each other, —(CH2)m1-E-(CH2)m2— (wherein E is an oxygen atom, a sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom, a C1-10 alkyl group, a C2-14 aryl group, a C1-10 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR8 (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), and each of m1 and m2 is independently an integer of from 0 to 5 provided that m1+m2 is 3, 4 or 5)))),

B is an oxygen atom, a sulfur atom or NR9 (wherein R9 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)) (provided that when A is a nitrogen atom, B is not NH),
R1 is a C2-14 aryl group (the C2-14 aryl group may be substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group, OCHO, a cyano group, a hydroxyl group, a protected hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyl group, the C1-10 alkylcarbonyloxy group and the C1-10 alkoxycarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a thiol group and an amino group (the thiol group and the amino group may be optionally substituted with one or two substituents selected from the group consisting of: a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group and a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)))),
L1 is a bond, CR10R11 (wherein each of R10 and R11 is independently a hydrogen atom or a C1-6 alkyl group (the C1-6 alkyl group may be substituted with one or more halogen atoms)), an oxygen atom, a sulfur atom or NR12 (wherein R12 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)),
X is OR13, SR13 or NR14R15 (wherein R13 is a hydrogen atom, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), and each of R14 and R15 is independently a hydrogen atom, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)),
R2 is a hydrogen atom, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyloxy group, (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkoxycarbonyl group, the C1-10 alkylcarbonyloxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)
L2 is a bond, CR34R35 (wherein each of R34 and R35 is independently a hydrogen atom or a C1-6 alkyl group (the C1-6 alkyl group may be substituted with one or more halogen atoms)), an oxygen atom, a sulfur atom or NR16 (wherein R16 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)),
L3 is a bond, CR17R18 (wherein each of R17 and R18 is independently a hydrogen atom, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), an oxygen atom, a sulfur atom or NR19 (wherein R19 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)),
L4 is a bond, CR20R21 (wherein each of R20 and R21 is independently a hydrogen atom, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 lo alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino-group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) ), an oxygen atom, a sulfur atom or NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)),
Y is an oxygen atom, a sulfur atom or NR23 (wherein R23 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), and
R3 is a C2-14 aryl group (the C2-14 aryl group may be substituted with one or more substituents independently represented by —W1(CW2W3)mW4 (wherein W1 is (CR24R25)n (wherein each of R24 and R25 is independently a hydrogen atom or a C1-6 alkyl group, (the C1-6 alkyl group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR36 (wherein R36 is a hydrogen atom, a C1-6 alkyl group, a formyl group or a C1-6 alkylcarbonyl group), each of W2 and W3 is independently a hydrogen atom or a C1-3 alkyl group (the C1-3 alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3, and W4 is a hydroxyl group, a thiol group, an amino group, a formyl group, a halogen atom, a nitro group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group, a mono- or di-C1-10 alkylamino group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group and the mono- or di-C1-10 alkylamino group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, a amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a thiol group, a phosphonic acid group, a sulfonic acid group, a tetrazole group, a C2-14 aryl group and a C2-14 aryloxy group), SO2R28, SOR28, COR28 (wherein R28 is a hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group, a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more is halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or NR29R30 (wherein each of R29 and R30 is independently a hydrogen atom, a hydroxyl group, a formyl group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), or R29 and R30, together with each other means —(CH2)m3-G-(CH2)m4— (wherein G is an oxygen atom, a sulfur atom, a CR31R32 (wherein each of R31 and R32 is independently a hydrogen atom, a C1-10 alkyl group, a C2-14 aryl group, a C1-10 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR33 (wherein R33 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), and each of m3 and m4 is independently an integer of from 0 to 5, provided that m3+m4 is 3, 4 or 5))), a tetrazole group, or a phosphonic acid group)), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

    2. The compound according to 1, wherein A is a nitrogen atom, and B is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    3. The compound according to 1, wherein A is a nitrogen atom, and B is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    4. The compound according to 1, wherein A is a nitrogen atom, and B is NR9 (wherein R9 is a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    5. The compound according to 1, wherein A is CR4 (wherein R4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C2-6 alkenyl or a C2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a C1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2-6 alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group, a mono- or di-C1-10 alkylamino group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group, the mono- or di-C1-10 alkylamino group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), or R6 and R7 mean, together with each other, —(CH2)m1-E-(CH2)m2— (wherein E is an oxygen atom, a sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom, a C1-10 alkyl group, a C2-14 aryl group, a C1-10 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR8 (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), and each of m1 and m2 is independently an integer of from 0 to 5 provided that m1+m2 is 3, 4 or 5)))), and B is a oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    6. The compound according to 1, wherein A is CR4 (wherein R4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C2-6 alkenyl or a C2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a C1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2-6 alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group, a mono- or di-C1-10 alkylamino group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group, the mono- or di-C1-10 alkylamino group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), or R6 and R7 mean, together with each other, —(CH2)m1-E-(CH2)m2— (wherein E is an oxygen atom, a sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom, a C1-10 alkyl group, a C2-14 aryl group, a C1-10 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR8 (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), and each of m1 and m2 is independently an integer of from 0 to 5 provided that m1+m2 is 3, 4 or 5)))), and B is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    7. The compound according to 1, wherein A is CR4 (wherein R4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C2-6 alkenyl or a C2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a C1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2-6 alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group, a mono- or di-C1-10 alkylamino group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group, the mono- or di-C1-10 alkylamino group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), or R6 and R7 mean, together with each other, —(CH2)m1-E-(CH2)m2— (wherein E is an oxygen atom, a sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom, a C1-10 alkyl group, a C2-14 aryl group, a C1-10 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR8 (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), and each of m1 and m2 is independently an integer of from 0 to 5 provided that m1+m2 is 3, 4 or 5)))), and


B is NR9 (wherein R9 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

    8. The compound according to 1, wherein L1 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    9. The compound according to 2, wherein L1 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    10. The compound according to 3, wherein L1 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    11. The compound according to 4, wherein L1 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    12. The compound according to 5, wherein L1 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    13. The compound according to 6, wherein L1 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    14. The compound according to 7, wherein L1 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    15. The compound according to 1, wherein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    16. The compound according to 2, wherein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    17. The compound according to 3, wherein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    18. The compound according to 4, wherein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    19. The compound according to 5, wherein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    20. The compound according to 6, wherein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    21. The compound according to 7, wherein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    22. The compound according to 8, wherein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    23. The compound according to 9, wherein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    24. The compound according to 10, whrerein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    25. The compound according to 11, wherein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    26. The compound according to 12, wherein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    27. The compound according to 13, whrerein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    28. The compound according to 14, whrerein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    29. The compound according to 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27 or 28, whrerein L3 is NR19 (wherein R19 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    30. The compound according to 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27 or 28, wherein L3 is NH, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    31. The compound according to 29, wherein L is NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    32. The compound according to 30, whrerein L4 is the same as defined in 31, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    33. The compound according to 29, whrerein L4 is NH, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    34. The compound according to 30, whrerein L4 is NH, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    35. The compound according to 29, whrerein L4 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    36. The compound according to 30, whrerein L4 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    37. The compound according to 31, wherein Y is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    38. The compound according to 32, wherein Y is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    39. The compound according to 33, wherein Y is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    40. The compound according to 34, wherein Y is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    41. The compound according to 35, wherein Y is an-oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    42. The compound according to 36, wherein Y is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    43. The compound according to 31, wherein Y is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    44. The compound according to 32, wherein Y is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    45. The compound according to 33, wherein Y is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    46. The compound according to 34, wherein Y is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    47. The compound according to 35, wherein Y is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    48. The compound according to 36, wherein Y is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    49. The compound according to 37, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    50. The compound according to 38, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    51. The compound according to 39, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    52. The compound according to 40, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    53. The compound according to 41, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    54. The compound according to 42, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    55. The compound according to 43, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    56. The compound according to 44, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    57. The compound according to 45, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    58. The compound according to 46, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    59. The compound according to 47, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    60. The compound according to 48, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    61. The compound according to 37, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    62. The compound according to 38, wherein R3 is the same as defined in 61, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 63. The compound according to 39, wherein R3 is the same as defined in 61, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    64. The compound according to 40, wherein R3 is the same as defined in 61, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    65. The compound according to 41, wherein R3 is the same as defined in 61, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    66. The compound according to 42, wherein R3 is the same as defined in 61, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    67. The compound according to 49, wherein R3 is the same as defined in 61, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    68. The compound according to 50, wherein R3 is the same as defined in 61, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    69. The compound according to 51, wherein R3 is the same as defined in 61, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    70. The compound according to 52, wherein R3 is the same as defined in 61, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    71. The compound according to 53, wherein R3 is the same as defined in 61, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    72. The compound according to 54, wherein R3 is the same as defined in 61, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    73. The compound according to 43, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    74. The compound according to 44, wherein R3 is the same as defined in 73, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    75. The compound according to 45, wherein R3 is the same as defined in 73, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    76. The compound according to 46, wherein R3 is the same as defined in 73, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    77. The compound according to 47, wherein R3 is the same as defined in 73, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    78. The compound according to 48, wherein R3 is the same as defined in 73, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    79. The compound according to 55, wherein R3 is the same as defined in 73, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    80. The compound according to 56, wherein R3 is the same as defined in 73, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    81. The compound according to 57, wherein R3 is the same as defined in 73, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    82. The compound according to 58, wherein R3 is the same as defined in 73, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    83. The compound according to 59, wherein R3 is the same as defined in 73, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    84. The compound according to 60, wherein R3 is the same as defined in 73, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    85. The compound according to 37, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    86. The compound according to 38, wherein R3 is the same as defined in 85, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    87. The compound according to 39, wherein R3 is the same as defined in 85, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    88. The compound according to 40, wherein R3 is the same as defined in 85, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    89. The compound according to 41, wherein R3 is the same as defined in 85, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    90. The compound according to 42, wherein R3 is the same as defined in 85, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    91. The compound according to 49, wherein R3 is the same as defined in 85, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    92. The compound according to 50, wherein R3 is the same as defined in 85, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    93. The compound according to 51, wherein R3 is the same as defined in 85, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    94. The compound according to 52, wherein R3 is the same as defined in 85, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    95. The compound according to 53, wherein R3 is the same as defined in 85, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    96. The compound according to 54, wherein R3 is the same as defined in 85, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    97. The compound according to 43, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    98. The compound according to 44, wherein R3 is the same as defined in 97, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    99. The compound according to 45, wherein R3 is the same as defined in 97, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    100. The compound according to 46, wherein R3 is the same as defined in 97, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    101. The compound according to 47, wherein R3 is the same as defined in 97, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    102. The compound according to 48, wherein R3 is the same as defined in 97, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    103. The compound according to 55, wherein R3 is the same as defined in 97, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    104. The compound according to 56, wherein R3 is the same as defined in 97, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    105. The compound according to 57, wherein R3 is the same as defined in 97, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    106. The compound according to 58, wherein R3 is the same as defined in 97, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    107. The compound according to 59, wherein R3 is the same as defined in 97, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    108. The compound according to 60, wherein R3 is the same as defined in 97, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    109. The compound according to 37, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:


a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
and one or more substituents selected from the group consisting of:
a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

    110. The compound according to 38, wherein R3 is the same as defined in 109, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    111. The compound according to 39, wherein R3 is the same as defined in 109, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    112. The compound according to 40, wherein R3 is the same as defined in 109, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    113. The compound according to 41, wherein R3 is the same as defined in 109, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    114. The compound according to 42, wherein R3 is the same as defined in 109, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    115. The compound according to 49, wherein R3 is the same as defined in 109, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    116. The compound according to 50, wherein R3 is the same as defined in 109, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    117. The compound according to 51, wherein R3 is the same as defined in 109, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    118. The compound according to 52, wherein R3 is the same as defined in 109, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    119. The compound according to 53, wherein R3 is the same as defined in 109, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    120. The compound according to 54, wherein R3 is the same as defined in 109, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    121. The compound according to 43, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:


a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
and one or more substituents selected from the group consisting of:
a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

    122. The compound according to 44, wherein R3 is the same as defined in 121, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    123. The compound according to 45, wherein R3 is the same as defined in 121, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    124. The compound according to 46, wherein R3 is the same as defined in 121, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    125. The compound according to 47, wherein R3 is the same as defined in 121, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    126. The compound according to 48, wherein R3 is the same as defined in 121, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    127. The compound according to 55, wherein R3 is the same as defined in 121, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    128. The compound according to 56, wherein R3 is the same as defined in 121, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    129. The compound according to 57, wherein R3 is the same as defined in 121, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    130. The compound according to 58, wherein R3 is the same as defined in 121, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    131. The compound according to 59, wherein R3 is the same as defined in 121, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    132. The compound according to 60, wherein R3 is the same as defined in 121, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    133. The thrombopoietin receptor activator according to 1.
    134. The thrombopoietin receptor activator according to 2.
    135. The thrombopoietin receptor activator according to 3.
    136. The thrombopoietin receptor activator according to 4.
    137. The thrombopoietin receptor activator according to 5.
    138. The thrombopoietin receptor activator according to 6.
    139. The thrombopoietin receptor activator according to 7.
    140. The thrombopoietin receptor activator according to any one of 8 to 14.
    141. The thrombopoietin receptor activator according to any one of 15 to 28.
    142. The thrombopoietin receptor activator according to 29.
    143. The thrombopoietin receptor activator according to 30.
    144. The thrombopoietin receptor activator according to 31 or 32.
    145. The thrombopoietin receptor activator according to 33 or 34.
    146. The thrombopoietin receptor activator according to 35 or 36.
    147. The thrombopoietin receptor activator according to any one of 37 to 42.
    148. The thrombopoietin receptor activator according to any one of 43 to 48.
    149. The thrombopoietin receptor activator according to any one of 49 to 54.
    150. The thrombopoietin receptor activator according to any one of 55 to 60.
    151. The thrombopoietin receptor activator according to any one of 61 to 72.
    152. The thrombopoietin receptor activator according to any one of 73 to 84.
    153. The thrombopoietin receptor activator according to any one of 85 to 96.
    154. The thrombopoietin receptor activator according to any one of 97 to 108.
    155. The thrombopoietin receptor activator according to any one of 109 to 120.
    156. The thrombopoietin receptor activator according to any one of 121 to 132.
    157. A preventive, therapeutic or improving agent for diseases against which activation of the thrombopoietin receptor is effective, which contains the thrombopoietin receptor activator according to any one of 133 to 156, a tautomer, prodrug or pharmaceutically acceptable salt of the activator or a solvate thereof, as an active ingredient.
    158. A platelet increasing agent containing the thrombopoietin receptor activator according to any one of 133 to 156, a tautomer, prodrug or pharmaceutically acceptable salt of the activator or a solvate thereof, as an active ingredient.
    159. Medicament containing the compound according to any one of 1 to 132, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof, as an active ingredient.





BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 shows the proliferation of UT7/EPO-mpl cells when stimulated by the compound of the present invention (Synthetic Example 3).
FIG. 2 shows the proliferation of UT7/EPO cells when stimulated by the compound of the present invention (Synthetic Example 3).



BEST MODE FOR CARRYING OUT THE INVENTION
Now, the present invention will be described in detail.
In the present invention, “n” denotes normal, “i” denotes iso, “s” denotes secondary, “t” denotes tertiary, “c” denotes cyclo, “o” denotes ortho, “m” denotes meta, “p” denotes para, “Ph” denotes phenyl, “Py” denotes pyridyl, “Ac” denotes acetyl, “Naphthyl” denotes naphthyl, “Me” denotes methyl, “Et” denotes ethyl, “Pr” denotes propyl, and “Bu” denotes butyl.
First, the terms in the respective substituents R1 to R36 will be explained.
As a halogen atom, a fluorine atom, a chlorine atom, a bromine atom or an iodine atom may be mentioned.
A C1-3 alkyl group may be linear, branched or a C3 cycloalkyl group, and methyl, ethyl, n-propyl, i-propyl and c-propyl and the like may be mentioned.
A C1-6 alkyl group may be linear, branched or a C3-6 cycloalkyl group, and in addition to those mentioned above, n-butyl, i-butyl, s-butyl, t-butyl, c-butyl, 1-methyl-c-propyl, 2-methyl-c-propyl, n-pentyl, 1-methyl-n-butyl, 2-methyl-n-butyl, 3-methyl-n-butyl, 1,1-dimethyl-n-propyl, 1,2-dimethyl-n-propyl, 2,2-dimethyl-n-propyl, 1-ethyl-n-propyl, c-pentyl, 1-methyl-c-butyl, 2-methyl-c-butyl, 3-methyl-c-butyl, 1,2-dimethyl-c-propyl, 2,3-dimethyl-c-propyl, 1-ethyl-c-propyl, 2-ethyl-c-propyl, n-hexyl, 1-methyl-n-pentyl, 2-methyl-n-pentyl, 3-methyl-n-pentyl, 4-methyl-n-pentyl, 1,1-dimethyl-n-butyl, 1,2-dimethyl-n-butyl, 1,3-dimethyl-n-butyl, 2,2-dimethyl-n-butyl, 2,3-dimethyl-n-butyl, 3,3-dimethyl-n-butyl, 1-ethyl-n-butyl, 2-ethyl-n-butyl, 1,1,2-trimethyl-n-propyl, 1,2,2-trimethyl-n-propyl, 1-ethyl-1-methyl-n-propyl, 1-ethyl-2-methyl-n-propyl, c-hexyl, 1-methyl-c-pentyl, 2-methyl-c-pentyl, 3-methyl-c-pentyl, 1-ethyl-c-butyl, 2-ethyl-c-butyl, 3-ethyl-c-butyl, 1,2-dimethyl-c-butyl, 1,3-dimethyl-c-butyl, 2,2-dimethyl-c-butyl, 2,3-dimethyl-c-butyl, 2,4-dimethyl-c-butyl, 3,3-dimethyl-c-butyl, 1-n-propyl-c-propyl, 2-n-propyl-c-propyl, 1-i-propyl-c-propyl, 2-i-propyl-c-propyl, 1,2,2-trimethyl-c-propyl, 1,2,3-trimethyl-c-propyl, 2,2,3-trimethyl-c-propyl, 1-ethyl-2-methyl-c-propyl, 2-ethyl-1-methyl-c-propyl, 2-ethyl-2-methyl-c-propyl, 2-ethyl-3-methyl-c-propyl and the like may be mentioned.
A C1-10 alkyl group may be linear, branched or a C3-10 cycloalkyl group, and in addition to those mentioned above, 1-methyl-1-ethyl-n-pentyl, 1-heptyl, 2-heptyl, 1-ethyl-1,2-dimethyl-n-propyl, 1-ethyl-2,2-dimethyl-n-propyl, 1-octyl, 3-octyl, 4-methyl-3-n-heptyl, 6-methyl-2-n-heptyl, 2-propyl-1-n-heptyl, 2,4,4-trimethyl-1-n-pentyl, 1-nonyl, 2-nonyl, 2,6-dimethyl-4-n-heptyl, 3-ethyl-2,2-dimethyl-3-n-pentyl, 3,5,5-trimethyl-1-n-hexyl, 1-decyl, 2-decyl, 4-decyl, 3,7-dimethyl-l-n-octyl, 3,7-dimethyl-3-n-octyl and the like may be mentioned.
As a C2-6 alkynyl group, ethynyl, 1-propynyl, 2-propynyl, 1-butynyl, 2-butynyl, 3-butynyl, 1-methyl-2-propynyl, 1-pentynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 1-methyl-2-butynyl, 1-methyl-3-butynyl, 2-methyl-3-butynyl, 3-methyl-1-butynyl, 1,1-dimethyl-2-propynyl, 2-ethyl-2-propynyl, 1-hexynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-hexynyl, 1-methyl-2-pentynyl, 1-methyl-3-pentynyl, 1-methyl-4-pentynyl, 2-methyl-3-pentynyl, 2-methyl-4-pentynyl, 3-methyl-1-pentynyl, 3-methyl-4-pentynyl, 4-methyl-l-pentynyl, 4-methyl-2-pentynyl, 1,1-dimethyl-2-butynyl, 1,1-dimethyl-3-butynyl, 1,2-dimethyl-3-butynyl, 2,2-dimethyl-3-butynyl, 3,3-dimethyl-1-butynyl, 1-ethyl-2-butynyl, 1-ethyl-3-butynyl, 1-n-propyl-2-propynyl, 2-ethyl-3-butynyl, 1-methyl-l-ethyl-2-propynyl, 1-i-propyl-2-propynyl and the like may be mentioned.
A C2-6 alkenyl group may be linear, branched or a C3-6 cycloalkenyl group, and ethenyl, 1-propenyl, 2-propenyl, 1-methyl-1-ethenyl, 1-butenyl, 2-butenyl, 3-butenyl, 2-methyl-1-propenyl, 2-methyl-2-propenyl, 1-ethylethenyl, 1-methyl-1-propenyl, 1-methyl-2-propenyl, 1-pentenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 1-n-propylethenyl, 1-methyl-1-butenyl, 1-methyl-2-butenyl, 1-methyl-3-butenyl, 2-ethyl-2-propenyl, 2-methyl-1-butenyl, 2-methyl-2-butenyl, 2-methyl-3-butenyl, 3-methyl-1-butenyl, 3-methyl-2-butenyl, 3-methyl-3-butenyl, 1,1-dimethyl-2-propenyl, 1-i-propylethenyl, 1,2-dimethyl-l-propenyl, 1,2-dimethyl-2-propenyl, 1-c-pentenyl, 2-c-pentenyl, 3-c-pentenyl, 1-hexenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 1-methyl-1-pentenyl, 1-methyl-2-pentenyl, 1-methyl-3-pentenyl, 1-methyl-4-pentenyl, 1-n-butylethenyl, 2-methyl-1-pentenyl, 2-methyl-2-pentenyl, 2-methyl-3-pentenyl, 2-methyl-4-pentenyl, 2-n-propyl-2-propenyl, 3-methyl-1-pentenyl, 3-methyl-2-pentenyl, 3-methyl-3-pentenyl, 3-methyl-4-pentenyl, 3-ethyl-3-butenyl, 4-methyl-1-pentenyl, 4-methyl-2-pentenyl, 4-methyl-3-pentenyl, 4-methyl-4-pentenyl, 1,1-dimethyl-2-butenyl, 1,1-dimethyl-3-butenyl, 1,2-dimethyl-1-butenyl, 1,2-dimethyl-2-butenyl, 1,2-dimethyl-3-butenyl, 1-methyl-2-ethyl-2-propenyl, 1-s-butylethenyl, 1,3-dimethyl-1-butenyl, 1,3-dimethyl-2-butenyl, 1,3-dimethyl-3-butenyl, 1-i-butylethenyl, 2,2-dimethyl-3-butenyl, 2,3-dimethyl-1-butenyl, 2,3-dimethyl-2-butenyl, 2,3-dimethyl-3-butenyl, 2-i-propyl-2-propenyl, 3,3-dimethyl-1-butenyl, 1-ethyl-1-butenyl, 1-ethyl-2-butenyl, 1-ethyl-3-butenyl, 1-n-propyl-1-propenyl, 1-n-propyl-2-propenyl, 2-ethyl-1-butenyl, 2-ethyl-2-butenyl, 2-ethyl-3-butenyl, 1,1,2-trimethyl-2-propenyl, 1-t-butylethenyl, 1-methyl-1-ethyl-2-propenyl, 1-ethyl-2-methyl-1-propenyl, 1-ethyl-2-methyl-2-propenyl, 1-i-propyl-1-propenyl, 1-i-propyl-2-propenyl, 1-methyl-2-c-pentenyl, 1-methyl-3-c-pentenyl, 2-methyl-1-c-pentenyl, 2-methyl-2-c-pentenyl, 2-methyl-3-c-pentenyl, 2-methyl-4-c-pentenyl, 2-methyl-5-c-pentenyl, 2-methylene-c-pentyl, 3-methyl-1-c-pentenyl, 3-methyl-2-c-pentenyl, 3-methyl-3-c-pentenyl, 3-methyl-4-c-pentenyl, 3-methyl-5-c-pentenyl, 3-methylene-c-pentyl, 1-c-hexenyl, 2-c-hexenyl, 3-c-hexenyl and the like may be mentioned.
A C2-14 aryl group containing no hetero atoms as ring constituting atoms or a C2-9 aromatic heterocyclic group, and a C2-9 aromatic heterocyclic group may be a 5 to 7-membered C2-6 heteromonocyclic group or 8 to 10-membered C5-9 fused heterobicyclic group containing from 1 to 3 oxygen atoms, nitrogen atoms or sulfur atoms singly or in combination.
As a C6-14 aryl group containing no hetero atoms, a phenyl group, a 1-indenyl group, a 2-indenyl group, a 3-indenyl group, a 4-indenyl group, a 5-indenyl group, a 6-indenyl group, a 7-indenyl group, an α-naphthyl group, a β-naphthyl group, a 1-tetrahydronaphthyl group, a 2-tetrahydronaphthyl group, a 5-tetrahydronaphthyl group, a 6-tetrahydronaphthyl group, an o-biphenylyl group, a m-biphenylyl group, a p-biphenylyl group, a 1-anthryl group, a 2-anthryl group, a 9-anthryl group, a 1-phenanthryl group, a 2-phenanthryl group, a 3-phenanthryl group, a 4-phenanthryl group, a 9-phenanthryl group or the like may be mentioned.
A 5 to 7-membered C2-6 heteromonocyclic group may be a 2-thienyl group, a 3-thienyl group, a 2-furyl group, a 3-furyl group, a 2-pyranyl group, a 3-pyranyl group, a 4-pyranyl group, a 1-pyrrolyl group, a 2-pyrrolyl group, a 3-pyrrolyl group, a 1-imidazolyl group, a 2-imidazolyl group, a 4-imidazolyl group, a 1-pyrazolyl group, a 3-pyrazolyl group, a 4-pyrazolyl group, a 2-thiazolyl group, a 4-thiazolyl group, a 5-thiazolyl group, a 3-isothiazolyl group, a 4-isothiazolyl group, a 5-isothiazolyl group, a 2-oxazolyl group, a 4-oxazolyl group, a 5-oxazolyl group, a 3-isoxazolyl group, a 4-isoxazolyl group, a 5-isoxazolyl group, a 2-pyridyl group, a 3-pyridyl group, a 4-pyridyl group, a 2-pyrazinyl group, a 2-pyrimidinyl group, a 4-pyrimidinyl group, a 5-pyrimidinyl group, a 3-pyridazinyl group, a 4-pyridazinyl group, a 2-1,3,4-oxadiazolyl group, a 2-1,3,4-thiadiazolyl group, a 3-1,2,4-oxadiazolyl group, a 5-1,2,4-oxadiazolyl group, a 3-1,2,4-thiadiazolyl group, a 5-1,2,4-thiadiazolyl group, a 3-1,2,5-oxadiazolyl group, a 3-1,2,5-thiadiazolyl group or the like.
A 8 to 10-membered C5-9 fused heterocyclic group may be a 2-benzofuranyl group, a 3-benzofuranyl group, a 4-benzofuranyl group, a 5-benzofuranyl group, a 6-benzofuranyl group, a 7-benzofuranyl group, a 1-isobenzofuranyl group, a 4-isobenzofuranyl group, a 5-isobenzofuranyl group, a 2-benzothienyl group, a 3-benzothienyl group, a 4-benzothienyl group, a 5-benzothienyl group, a 6-benzothienyl group, a 7-benzothienyl group, a 1-isobenzothienyl group, a 4-isobenzothienyl group, a 5-isobenzothienyl group, a 2-chromenyl group, a 3-chromenyl group, a 4-chromenyl group, a 5-chromenyl group, a 6-chromenyl group, a 7-chromenyl group, a 8-chromenyl group, a 1-indolizinyl group, a 2-indolizinyl group, a 3-indolizinyl group, a 5-indolizinyl group, a 6-indolizinyl group, a 7-indolizinyl group, a 8-indolizinyl group, a 1-isoindolyl group, a 2-isoindolyl group, a 4-isoindolyl group, a 5-isoindolyl group, a 1-indolyl group, a 2-indolyl group, a 3-indolyl group, a 4-indolyl group, a 5-indolyl group, a 6-indolyl group, a 7-indolyl group, 1-indazolyl group, a 2-indazolyl group, a 3-indazolyl group, a 4-indazolyl group, a 5-indazolyl group, a 6-indazolyl group, a 7-indazolyl group, a 1-purinyl group, a 2-purinyl group, a 3-purinyl group, a 6-purinyl group, a 7-purinyl group, a 8-purinyl group, a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group, a 8-quinolyl group, a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolyl group, a 7-isoquinolyl group, a 8-isoquinolyl group, a 1-phthalazinyl group, a 5-phthalazinyl group, a 6-phthalazinyl group, a 1-2,7-naphthyridinyl group, a 3-2,7-naphthyridinyl group, a 4-2,7-naphthyridinyl group, a 1-2,6-naphthyridinyl group, a 3-2,6-naphthyridinyl group, a 4-2,6-naphthyridinyl group, a 2-1,8-naphthyridinyl group, a 3-1,8-naphthyridinyl group, a 4-1,8-naphthyridinyl group, a 2-1,7-naphthyridinyl group, a 3-1,7-naphthyridinyl group, a 4-1,7-naphthyridinyl group, a 5-1,7-naphthyridinyl group, a 6-1,7-naphthyridinyl group, a 8-1,7-naphthyridinyl group, 2-1,6-naphthyridinyl group, a 3-1,6-naphthyridinyl group, a 4-1,6-naphthyridinyl group, a 5-1,6-naphthyridinyl group, a 7-1,6-naphthyridinyl group, a 8-1,6-naphthyridinyl group, a 2-1,5-naphthyridinyl group, a 3-1,5-naphthyridinyl group, a 4-1,5-naphthyridinyl group, a 6-1,5-naphthyridinyl group, a 7-1,5-naphthyridinyl group, a 8-1,5-naphthyridinyl group, a 2-quinoxalinyl group, a 5-quinoxalinyl group, a 6-quinoxalinyl group, a 2-quinazolinyl group, a 4-quinazolinyl group, a 5-quinazolinyl group, a 6-quinazolinyl group, a 7-quinazolinyl group, a 8-quinazolinyl group, a 3-cinnolinyl group, a 4-cinnolinyl group, a 5-cinnolinyl group, a 6-cinnolinyl group, a 7-cinnolinyl group, a 8-cinnolinyl group, a 2-pterdinyl group, a 4-pterdinyl group, a 6-pterdinyl group, a 7-pterdinyl group or the like.
A C2-14 aryloxy group may be a C6-14 arloxy group containing no hetero atoms as ring constituting atoms or a C2-9 aromatic heterocyclic oxy group, and a C2-9 aromatic heterocyclic oxy group may be a 5 to 7-membered C2-6 heteromonocyclic oxy group or 8 to 10-membered C5-9 fused heterobicyclic oxy group containing from 1 to 3 oxygen atoms, nitrogen atoms or sulfur atoms singly or in combination.
As a C6-14 aryloxy group containing no hetero atoms, a phenyloxy group, a 1-indenyloxy group, a 2-indenyloxy group, a 3-indenyloxy group, a 4-indenyloxy group, a 5-indenyloxy group, a 6-indenyloxy group, a 7-indenyloxy group, an α-naphthyloxy group, a β-naphthyloxy group, a 1-tetrahydronaphthyloxy group, a 2-tetrahydronaphthyloxy group, a 5-tetrahydronaphthyloxy group, a 6-tetrahydronaphthyloxy group, an o-biphenylyloxy group, a m-biphenylyloxy group, a p-biphenylyloxy group, a 1-anthryloxy group, a 2-anthryloxy group, a 9-anthryloxy group, a 1-phenanthryloxy group, a 2-phenanthryloxy group, a 3-phenanthryloxy group, a 4-phenanthryloxy group, a 9-phenanthryloxy group or the like may be mentioned.
A 5 to 7-membered C2-6 heteromonocyclic oxy group may be a 2-thienyloxy group, a 3-thienyloxy group, a 2-furyloxy group, a 3-furyloxy group, a 2-pyranyloxy group, a 3-pyranyloxy group, a 4-pyranyloxy group, a 1-pyrrolyloxy group, a 2-pyrrolyloxy group, a 3-pyrrolyloxy group, a 1-imidazolyloxy group, a 2-imidazolyloxy group, a 4-imidazolyloxy group, a 1-pyrazolyloxy group, a 3-pyrazolyloxy group, a 4-pyrazolyloxy group, a 2-thiazolyloxy group, a 4-thiazolyloxy group, a 5-thiazolyloxy group, a 3-isothiazolyloxy group, a 4-isothiazolyloxy group, a 5-isothiazolyloxy group, a 2-oxazolyloxy group, a 4-oxazolyloxy group, a 5-oxazolyloxy group, a 3-isoxazolyloxy group, a 4-isoxazolyloxy group, a 5-isoxazolyloxy group, a 2-pyridyloxy group, a 3-pyridyloxy group, a 4-pyridyloxy group, a 2-pyrazinyloxy group, a 2-pyrimidinyloxy group, a 4-pyrimidinyloxy group, a 5-pyrimidinyloxy group, a 3-pyridazinyloxy group, a 4-pyridazinyloxy group, a 2-1,3,4-oxadiazolyloxy group, a 2-1,3,4-thiadiazolyloxy group, a 3-1,2,4-oxadiazolyloxy group, a 5-1,2,4-oxadiazolyloxy group, a 3-1,2,4-thiadiazolyloxy group, a 5-1,2,4-thiadiazolyloxy group, a 3-1,2,5-oxadiazolyloxy group, a 3-1,2,5-thiadiazolyloxy group or the like.
A 8 to 10-membered C5-9 fused heterocyclic oxy group may be a 2-benzofuranyloxy group, a 3-benzofuranyloxy group, a 4-benzofuranyloxy group, a 5-benzofuranyloxy group, a 6-benzofuranyloxy group, a 7-benzofuranyloxy group, a 1-isobenzofuranyloxy group, a 4-isobenzofuranyloxy group, a 5-isobenzofuranyloxy group, a 2-benzothienyloxy group, a 3-benzothienyloxy group, a 4-benzothienyloxy group, a 5-benzothienyloxy group, a 6-benzothienyloxy group, a 7-benzothienyloxy group, a 1-isobenzothienyloxy group, a 4-isobenzothienyloxy group, a 5-isobenzothienyloxy group, a 2-chromenyloxy group, a 3-chromenyloxy group, a 4-chromenyloxy group, a 5-chromenyloxy group, a 6-chromenyloxy group, a 7-chromenyloxy group, a 8-chromenyloxy group, a 1-indolizinyloxy group, a 2-indolizinyloxy group, a 3-indolizinyloxy group, a 5-indolizinyloxy group, a 6-indolizinyloxy group, a 7-indolizinyloxy group, a 8-indolizinyloxy group, a 1-isoindolyloxy group, a 2-isoindolyloxy group, a 4-isoindolyloxy group, a 5-isoindolyloxy group, a 1-indolyloxy group, a 2-indolyloxy group, a 3-indolyloxy group, a 4-indolyloxy group, a 5-indolyloxy group, a 6-indolyloxy group, a 7-indolyloxy group, 1-indazolyloxy group, a 2-indazolyloxy group, a 3-indazolyloxy group, a 4-indazolyloxy group, a 5-indazolyloxy group, a 6-indazolyloxy group, a 7-indazolyloxy group, a 1-purinyloxy group, a 2-purinyloxy group, a 3-purinyloxy group, a 6-purinyloxy group, a 7-purinyloxy group, a 8-purinyloxy group, a 2-quinolyloxy group, a 3-quinolyloxy group, a 4-quinolyloxy group, a 5-quinolyloxy group, a 6-quinolyloxy group, a 7-quinolyloxy group, a 8-quinolyloxy group, a 1-isoquinolyloxy group, a 3-isoquinolyloxy group, a 4-isoquinolyloxy group, a 5-isoquinolyloxy group, a 6-isoquinolyloxy group, a 7-isoquinolyloxy group, a 8-isoquinolyloxy group, a 1-phthalazinyloxy group, a 5-phthalazinyloxy group, a 6-phthalazinyloxy group, a 1-2,7-naphthyridinyloxy group, a 3-2,7-naphthyridinyloxy group, a 4-2,7-naphthyridinyloxy group, a 1-2,6-naphthyridinyloxy group, a 3-2,6-naphthyridinyloxy group, a 4-2,6-naphthyridinyloxy group, a 2-1,8-naphthyridinyloxy group, a 3-1,8-naphthyridinyloxy group, a 4-1,8-naphthyridinyloxy group, a 2-1,7-naphthyridinyloxy group, a 3-1,7-naphthyridinyloxy group, a 4-1,7-naphthyridinyloxy group, a 5-1,7-naphthyridinyloxy group, a 6-1,7-naphthyridinyloxy group, a 8-1,7-naphthyridinyloxy group, 2-1,6-naphthyridinyloxy group, a 3-1,6-naphthyridinyloxy group, a 4-1,6-naphthyridinyloxy group, a 5-1,6-naphthyridinyloxy group, a 7-1,6-naphthyridinyloxy group, a 8-1,6-naphthyridinyloxy group, a 2-1,5-naphthyridinyloxy group, a 3-1,5-naphthyridinyloxy group, a 4-1,5-naphthyridinyloxy group, a 6-1,5-naphthyridinyloxy group, a 7-1,5-naphthyridinyloxy group, a 8-1,5-naphthyridinyloxy group, a 2-quinoxalinyloxy group, a 5-quinoxalinyloxy group, a 6-quinoxalinyloxy group, a 2-quinazolinyloxy group, a 4-quinazolinyloxy group, a 5-quinazolinyloxy group, a 6-quinazolinyloxy group, a 7-quinazolinyloxy group, a 8-quinazolinyloxy group, a 3-cinnolinyloxy group, a 4-cinnolinyloxy group, a 5-cinnolinyloxy group, a 6-cinnolinyloxy group, a 7-cinnolinyloxy group, a 8-cinnolinyloxy group, a 2-pterdinyloxy group, a 4-pterdinyloxy group, a 6-pterdinyloxy group, a 7-pterdinyloxy group or the like.
A C1-6 alkylcarbonyl group may linear, branched or a C3-6 cycloalkylcarbonyl group, and be methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, i-propylcarbonyl, c-propylcarbonyl, n-butylcarbonyl, i-butylcarbonyl, s-butylcarbonyl, t-butylcarbonyl, c-butylcarbonyl, 1-methyl-c-propylcarbonyl, 2-methyl-c-propylcarbonyl, n-pentylcarbonyl, 1-methyl-n-butylcarbonyl, 2-methyl-n-butylcarbonyl, 3-methyl-n-butylcarbonyl, 1,1-dimethyl-n-propylcarbonyl, 1,2-dimethyl-n-propylcarbonyl, 2,2-dimethyl-n-propylcarbonyl, 1-ethyl-n-propylcarbonyl, c-pentylcarbonyl, 1-methyl-c-butylcarbonyl, 2-methyl-c-butylcarbonyl, 3-methyl-c-butylcarbonyl, 1,2-dimethyl-c-propylcarbonyl, 2,3-dimethyl-c-propylcarbonyl, 1-ethyl-c-propylcarbonyl, 2-ethyl-c-propylcarbonyl, n-hexylcarbonyl, 1-methyl-n-pentylcarbonyl, 2-methyl-n-pentylcarbonyl, 3-methyl-n-pentylcarbonyl, 4-methyl-n-pentylcarbonyl, 1,1-dimethyl-n-butylcarbonyl, 1,2-dimethyl-n-butylcarbonyl, 1,3-dimethyl-n-butylcarbonyl, 2,2-dimethyl-n-butylcarbonyl, 2,3-dimethyl-n-butylcarbonyl, 3,3-dimethyl-n-butylcarbonyl, 1-ethyl-n-butylcarbonyl, 2-ethyl-n-butylcarbonyl, 1,1,2-trimethyl-n-propylcarbonyl, 1,2,2-trimethyl-n-propylcarbonyl, 1-ethyl-1-methyl-n-propylcarbonyl, 1-ethyl-2-methyl-n-propylcarbonyl, c-hexylcarbonyl, 1-methyl-c-pentylcarbonyl, 2-methyl-c-pentylcarbonyl, 3-methyl-c-pentylcarbonyl, 1-ethyl-c-butylcarbonyl, 2-ethyl-c-butylcarbonyl, 3-ethyl-c-butylcarbonyl, 1,2-dimethyl-c-butylcarbonyl, 1,3-dimethyl-c-butylcarbonyl, 2,2-dimethyl-c-butylcarbonyl, 2,3-dimethyl-c-butylcarbonyl, 2,4-dimethyl-c-butylcarbonyl, 3,3-dimethyl-c-butylcarbonyl, 1-n-propyl-c-propylcarbonyl, 2-n-propyl-c-propylcarbonyl, 1-i-propyl-c-propylcarbonyl, 2-i-propyl-c-propylcarbonyl, 1,2,2-trimethyl-c-propylcarbonyl, 1,2,3-trimethyl-c-propylcarbonyl, 2,2,3-trimethyl-c-propylcarbonyl, 1-ethyl-2-methyl-c-propylcarbonyl, 2-ethyl-1-methyl-c-propylcarbonyl, 2-ethyl-2-methyl-c-propylcarbonyl, 2-ethyl-3-methyl-c-propylcarbonyl or the like may be mentioned.
A C1-10 alkylcarbonyl may be linear, branched or a C3-10 cycloalkylcarbonyl group, and in addition to those mentioned above, 1-methyl-1-ethyl-n-pentylcarbonyl, 1-heptylcarbonyl, 2-heptylcarbonyl, 1-ethyl-1,2-dimethyl-n-propylcarbonyl, 1-ethyl-2,2-dimethyl-n-propylcarbonyl, 1-octylcarbonyl, 3-octylcarbonyl, 4-methyl-3-n-heptylcarbonyl, 6-methyl-2-n-heptylcarbonyl, 2-propyl-1-n-heptylcarbonyl, 2,4,4-trimethyl-1-n-pentylcarbonyl, 1-nonylcarbonyl, 2-nonylcarbonyl, 2,6-dimethyl-4-n-heptylcaronyl, 3-ethyl-2,2-dimethyl-3-n-pentylcarbonyl, 3,5,5-trimethyl-1-n-hexylcarbonyl, 1-decylcarbonyl, 2-decylcarbonyl, 4-decylcarbonyl, 3,7-dimethyl-1-n-octylcarbonyl, 3,7-dimethyl-3-n-octylcarbonyl or the like may be mentioned.
A C1-10 alkoxy group may be linear, branched or a C3-10 cycloalkoxy group, and methoxy, ethoxy, n-propoxy, i-propoxy, c-propoxy, n-butoxy, i-butoxy, s-butoxy, t-butoxy, c-butoxy, 1-methyl-c-propoxy, 2-methyl-c-propoxy, n-pentyloxy, 1-methyl-n-butoxy, 2-methyl-n-butoxy, 3-methyl-n-butoxy, 1,1-dimethyl-n-propoxy, 1,2-dimethyl-n-propoxy, 2,2-dimethyl-n-propoxy, 1-ethyl-n-propoxy, c-pentyloxy, 1-methyl-c-butoxy, 2-methyl-c-butoxy, 3-methyl-c-butoxy, 1,2-dimethyl-c-propoxy, 2,3-dimethyl-c-propoxy, 1-ethyl-c-propoxy, 2-ethyl-c-propoxy, n-hexyloxy, 1-methyl-n-pentyloxy, 2-methyl-n-pentyloxy, 3-methyl-n-pentyloxy, 4-methyl-n-pentyloxy, 1,1-dimethyl-n-butoxy, 1,2-dimethyl-n-butoxy, 1,3-dimethyl-n-butoxy, 2,2-dimethyl-n-butoxy, 2,3-dimethyl-n-butoxy, 3,3-dimethyl-n-butoxy, 1-ethyl-n-butoxy, 2-ethyl-n-butoxy, 1,1,2-trimethyl-n-propoxy, 1,2,2-trimethyl-n-propoxy, 1-ethyl-1-methyl-n-propoxy, 1-ethyl-2-methyl-n-propoxy, c-hexyloxy, 1-methyl-c-pentyloxy, 2-methyl-c-pentyloxy, 3-methyl-c-pentyloxy, 1-ethyl-c-butoxy, 2-ethyl-c-butoxy, 3-ethyl-c-butoxy, 1,2-dimethyl-c-butoxy, 1,3-dimethyl-c-butoxy, 2,2-dimethyl-c-butoxy, 2,3-dimethyl-c-butoxy, 2,4-dimethyl-c-butoxy, 3,3-dimethyl-c-butoxy, 1-n-propyl-c-propoxy, 2-n-propyl-c-propoxy, 1-i-propyl-c-propoxy, 2-i-propyl-c-propoxy, 1,2,2-trimethyl-c-propoxy, 1,2,3-trimethyl-c-propoxy, 2,2,3-trimethyl-c-propoxy, 1-ethyl-2-methyl-c-propoxy, 2-ethyl-1-methyl-c-propoxy, 2-ethyl-2-methyl-c-propoxy, 2-ethyl-3-methyl-c-propoxy, 1-methyl-1-ethyl-n-pentyloxy, 1-heptyloxy, 2-heptyloxy, 1-ethyl-1,2-dimethyl-n-propyloxy, 1-ethyl-2,2-dimethyl-n-propyloxy, 1-octyloxy, 3-octyloxy, 4-methyl-3-n-heptyloxy, 6-methyl-2-n-heptyloxy, 2-propyl-1-n-heptyloxy, 2,4,4-trimethyl-1-n-pentyloxy, 1-nonyloxy, 2-nonyloxy, 2,6-dimethyl-4-n-heptyloxy, 3-ethyl-2,2-dimethyl-3-n-pentyloxy, 3,5,5-trimethyl-1-n-hexyloxy, 1-decyloxy, 2-decyloxy, 4-decyloxy, 3,7-dimethyl-1-n-octyloxy, 3,7-dimethyl-3-n-octyloxy or the like may be mentioned.
A C1-6 alkoxycarbonyl group may be linear, branched or a C3-6 cycloalkoxycarbonyl group, and methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, i-propoxycarbonyl, c-propylcarbonyl, n-butoxycarbonyl, i-butoxycarbonyl, s-butoxycarbonyl, t-butoxycarbonyl, c-butoxycarbonyl, 1-methyl-c-propoxycarbonyl, 2-methyl-c-propoxycarbonyl, n-pentyloxycarbonyl, 1-methyl-n-butoxycarbonyl, 2-methyl-n-butoxycarbonyl, 3-methyl-n-butoxycarbonyl, 1,1-dimethyl-n-propoxycarbonyl, 1,2-dimethyl-n-propoxycarbonyl, 2,2-dimethyl-n-propoxycarbonyl, 1-ethyl-n-propoxycarbonyl, c-pentyloxycarbonyl, 1-methyl-c-butoxycarbonyl, 2-methyl-c-butoxycarbonyl, 3-methyl-c-butoxycarbonyl, 1,2-dimethyl-c-propoxycarbonyl, 2,3-dimethyl-c-propoxycarbonyl, 1-ethyl-c-propoxycarbonyl, 2-ethyl-c-propoxycarbonyl, n-hexyloxycarbonyl, 1-methyl-n-pentyloxycarbonyl, 2-methyl-n-pentyloxycarbonyl, 3-methyl-n-pentyloxycarbonyl, 4-methyl-n-pentyloxycarbonyl, 1,1-dimethyl-n-butoxycarbonyl, 1,2-dimethyl-n-butoxycarbonyl, 1,3-dimethyl-n-butoxycarbonyl, 2,2-dimethyl-n-butoxycarbonyl, 2,3-dimethyl-n-butoxycarbonyl, 3,3-dimethyl-n-butoxycarbonyl, 1-ethyl-n-butoxycarbonyl, 2-ethyl-n-butoxycarbonyl, 1,1,2-trimethyl-n-propoxycarbonyl, 1,2,2-trimethyl-n-propoxycarbonyl, 1-ethyl-1-methyl-n-propoxycarbonyl, 1-ethyl-2-methyl-n-propoxycarbonyl, c-hexyloxycarbonyl, 1-methyl-c-pentyloxycarbonyl, 2-methyl-c-pentyloxycarbonyl, 3-methyl-c-pentyloxycarbonyl, 1-ethyl-c-butoxycarbonyl, 2-ethyl-c-butoxycarbonyl, 3-ethyl-c-butoxycarbonyl, 1,2-dimethyl-c-butoxycarbonyl, 1,3-dimethyl-c-butoxycarbonyl, 2,2-dimethyl-c-butoxycarbonyl, 2,3-dimethyl-c-butoxycarbonyl, 2,4-dimethyl-c-butoxycarbonyl, 3,3-dimethyl-c-butoxycarbonyl, 1-n-propyl-c-propoxycarbonyl, 2-n-propyl-c-propoxycarbonyl, 1-i-propyl-c-propoxycarbonyl, 2-i-propyl-c-propoxycarbonyl, 1,2,2-trimethyl-c-propoxycarbonyl, 1,2,3-trimethyl-c-propoxycarbonyl, 2,2,3-trimethyl-c-propoxycarbonyl, 1-ethyl-2-methyl-c-propoxycarbonyl, 2-ethyl-1-methyl-c-propoxycarbonyl, 2-ethyl-2-methyl-c-propoxycarbonyl, 2-ethyl-3-methyl-c-propoxycarbonyl or the like may be mentioned.
A C1-10 alkoxycarbonyl group may be linear, branched or a C3-10 cycloalkoxycarbonyl group, and in addition to those mentioned above, 1-methyl-1-ethyl-n-pentyloxycarbonyl, 1-heptyloxycarbonyl, 2-heptyloxycarbonyl, 1-ethyl-1,2-dimethyl-n-propyloxycarbonyl, 1-ethyl-2,2-dimethyl-n-propyloxycarbonyl, 1-octyloxycarbonyl, 3-octyloxycarbonyl, 4-methyl-3-n-heptyloxycarbonyl, 6-methyl-2-n-heptyloxycarbonyl, 2-propyl-1-n-heptyloxycarbonyl, 2,4,4-trimethyl-1-n-pentyloxycarbonyl, 1-nonyloxycarbonyl, 2-nonyloxycarbonyl, 2,6-dimethyl-4-n-heptyloxycarbonyl, 3-ethyl-2,2-dimethyl-3-n-pentyloxycarbonyl, 3,5,5-trimethyl-1-n-hexyloxycarbonyl, 1-decyloxycarbonyl, 2-decyloxycarbonyl, 4-decyloxycarbonyl, 3,7-dimethyl-1-n-octyloxycarbonyl, 3,7-dimethyl-3-n-octyloxycarbonyl or the like may be mentioned.
A C1-10 alkylcarbonyloxy group may be linear, branched or a C3-10 cycloalkylcarbonyloxy group, and methylcarbonyloxy, ethylcarbonyloxy, n-propylcarbonyloxy, i-propylcarbonyloxy, c-propylcarbonyloxy, n-butylcarbonyloxy, i-butylcarbonyloxy, s-butylcarbonyloxy, t-butylcarbonyloxy, c-butylcarbonyloxy, 1-methyl-c-propylcarbonyloxy, 2-methyl-c-propylcarbonyloxy, n-pentylcarbonyloxy, 1-methyl-n-butylcarbonyloxy, 2-methyl-n-butylcarbonyloxy, 3-methyl-n-butylcarbonyloxy, 1,1-dimethyl-n-propylcarbonyloxy, 1,2-dimethyl-n-propylcarbonyloxy, 2,2-dimethyl-n-propylcarbonyloxy, 1-ethyl-n-propylcarbonyloxy, c-pentylcarbonyloxy, 1-methyl-c-butylcarbonyloxy, 2-methyl-c-butylcarbonyloxy, 3-methyl-c-butylcarbonyloxy, 1,2-dimethyl-c-propylcarbonyloxy, 2,3-dimethyl-c-propylcarbonyloxy, 1-ethyl-c-propylcarbonyloxy, 2-ethyl-c-propylcarbonyloxy, n-hexylcarbonyloxy, 1-methyl-n-pentylcarbonyloxy, 2-methyl-n-pentylcarbonyloxy, 3-methyl-n-pentylcarbonyloxy, 4-methyl-n-pentylcarbonyloxy, 1,1-dimethyl-n-butylcarbonyloxy, 1,2-dimethyl-n-butylcarbonyloxy, 1,3-dimethyl-n-butylcarbonyloxy, 2,2-dimethyl-n-butylcarbonyloxy, 2,3-dimethyl-n-butylcarbonyloxy, 3,3-dimethyl-n-butylcarbonyloxy, 1-ethyl-n-butylcarbonyloxy, 2-ethyl-n-butylcarbonyloxy, 1,1,2-trimethyl-n-propylcarbonyloxy, 1,2,2-trimethyl-n-propylcarbonyloxy, 1-ethyl-1-methyl-n-propylcarbonyloxy, 1-ethyl-2-methyl-n-propylcarbonyloxy, c-hexylcarbonyloxy, 1-methyl-c-pentylcarbonyloxy, 2-methyl-c-pentylcarbonyloxy, 3-methyl-c-pentylcarbonyloxy, 1-ethyl-c-butylcarbonyloxy, 2-ethyl-c-butylcarbonyloxy, 3-ethyl-c-butylcarbonyloxy, 1,2-dimethyl-c-butylcarbonyloxy, 1,3-dimethyl-c-butylcarbonyloxy, 2,2-dimethyl-c-butylcarbonylxoy, 2,3-dimethyl-c-butylcarbonyloxy, 2,4-dimethyl-c-butylcarbonyloxy, 3,3-dimethyl-c-butylcarbonyloxy, 1-n-propyl-c-propylcarbonyloxy, 2-n-propyl-c-propylcarbonyloxy, 1-i-propyl-c-propycarbonyloxy, 2-i-propyl-c-propylcarbonyloxy, 1,2,2-trimethyl-c-propylcarbonyloxy, 1,2,3-trimethyl-c-propylcarbonyloxy, 2,2,3-trimethyl-c-propylcarbonyloxy, 1-ethyl-2-methyl-c-propylcarbonyloxy, 2-ethyl-1-methyl-c-propylcarbonyloxy, 2-ethyl-2-methyl-c-propylcarbonyloxy, 2-ethyl-3-methyl-c-propylcarbonyloxy, 1-methyl-1-ethyl-n-pentylcarbonyloxy, 1-heptylcarbonyloxy, 2-heptylcarbonyloxy, 1-ethyl-1,2-dimethyl-n-propylcarbonyloxy, 1-ethyl-2,2-dimethyl-n-propylcarbonyloxy, 1-octylcarbonyloxy, 3-octylcarbonyloxy, 4-methyl-3-n-heptylcarbonyloxy, 6-methyl-2-n-heptylcarbonyloxy, 2-propyl-1-n-heptylcarbonyloxy, 2,4,4-trimethyl-1-n-pentylcarbonyloxy, 1-nonylcarbonyloxy, 2-nonylcarbonyloxy, 2,6-dimethyl-4-n-heptylcarbonyloxy, 3-ethyl-2,2-dimethyl-3-n-pentylcarbonyloxy, 3,5,5-trimethyl-1-n-hexylcarbonyloxy, 1-decylcarbonyloxy, 2-decylcarbonyloxy, 4-decylcarbonyloxy, 3,7-dimethyl-1-n-octylcarbonyloxy, 3,7-dimethyl-3-n-octylcarbonyloxy or the like may be mentioned.
A C1-10 alkylcarbonylamino group may be linear, branched or a C3-10 cycloalkylcarbonylamino group, and methylcarbonylamino, ethylcarbonylamino, n-propylcarbonylamino, i-propylcarbonylamino, c-propylcarbonylamino, n-butylcarbonylamino, i-butylcarbonylamino, s-butylcarbonylamino, t-butylcarbonylamino, c-butylcarbonylamino, 1-methyl-c-propylcarbonylamino, 2-methyl-c-propylcarbonylamino, n-pentylcarbonylamino, 1-methyl-n-butylcarbonylamino, 2-methyl-n-butylcarbonylamino, 3-methyl-n-butylcarbonylamino, 1,1-dimethyl-n-propylcarbonylamino, 1,2-dimethyl-n-propylcarbonylamino, 2,2-dimethyl-n-propylcarbonylamino, 1-ethyl-n-propylcarbonylamino, c-pentylcarbonylamino, 1-methyl-c-butylcarbonylamino, 2-methyl-c-butylcarbonylamino, 3-methyl-c-butylcarbonylamino, 1,2-dimethyl-c-propylcarbonylamino, 2,3-dimethyl-c-propylcarbonylamino, 1-ethyl-c-propylcarbonylamino, 2-ethyl-c-propylcarbonylamino, n-hexylcarbonylamino, 1-methyl-n-pentylcarbonylamino, 2-methyl-n-pentylcarbonylamino, 3-methyl-n-pentylcarbonylamino, 4-methyl-n-pentylcarbonylamino, 1,1-dimethyl-n-butylcarbonylamino, 1,2-dimethyl-n-butylcarbonylamino, 1,3-dimethyl-n-butylcarbonylamino, 2,2-dimethyl-n-butylcarbonylamino, 2,3-dimethyl-n-butylcarbonylamino, 3,3-dimethyl-n-butylcarbonylamino, 1-ethyl-n-butylcarbonylamino, 2-ethyl-n-butylcarbonylamino, 1,1,2-trimethyl-n-propylcarbonylamino, 1,2,2-trimethyl-n-propylcarbonylamino, 1-ethyl-l-methyl-n-propylcarbonylamino, 1-ethyl-2-methyl-n-propylcarbonylamino, c-hexylcarbonylamino, 1-methyl-c-pentylcarbonylamino, 2-methyl-c-pentylcarbonylamino, 3-methyl-c-pentylcarbonylamino, 1-ethyl-c-butylcarbonylamino, 2-ethyl-c-butylcarbonylamino, 3-ethyl-c-butylcarbonylamino, 1,2-dimethyl-c-butylcarbonylamino, 1,3-dimethyl-c-butylcarbonylamino, 2,2-dimethyl-c-butylcarbonylamino, 2,3-dimethyl-c-butylcarbonylamino, 2,4-dimethyl-c-butylcarbonylamino, 3,3-dimethyl-c-butylcarbonylamino, 1-n-propyl-c-propylcarbonylamino, 2-n-propyl-c-propylcarbonylamino, 1-i-propyl-c-propylcarbonylamino, 2-i-propyl-c-propylcarbonylamino, 1,2,2-trimethyl-c-propyl-carbonylamino, 1,2,3-trimethyl-c-propylcarbonylamino, 2,2,3-trimethyl-c-propylcarbonylamino, 1-ethyl-2-methyl-c-propylcarbonylamino, 2-ethyl-1-methyl-c-propylcarbonylamino, 2-ethyl-2-methyl-c-propylcarbonylamino, 2-ethyl-3-methyl-c-propylcarbonylamino, 1-methyl-1-ethyl-n-pentylcarbonylamino, 1-heptylcarbonylamino, 2-heptylcarbonylamino, 1-ethyl-1,2-dimethyl-n-propylcarbonylamino, 1-ethyl-2,2-dimethyl-n-propylcarbonylamino, 1-octylcarbonylamino, 3-octylcarbonylamino, 4-methyl-3-n-heptylcarbonylamino, 6-methyl-2-n-heptylcarbonylamino, 2-propyl-1-n-heptylcarbonylamino, 2,4,4-trimethyl-1-n-pentylcarbonylamino, 1-nonylcarbonylamino, 2-nonylcarbonylamino, 2,6-dimethyl-4-n-heptylcarbonylamino, 3-ethyl-2,2-dimethyl-3-n-pentylcarbonylamino, 3,5,5-trimethyl-1-n-hexylcarbonylamino, 1-decylcarbonylamino, 2-decylcarbonylamino, 4-decylcarbonylamino, 3,7-dimethyl-1-n-octylcarbonylamino, 3,7-dimethyl-3-n-octylcarbonylamino or the like may be mentioned.
A C1-10 monoalkylamino group may be linear, branched or a C3-10 cycloalkylamino group, and methylamino, ethylamino, n-propylamino, i-propylamino, c-propylamino, n-butylamino, i-butylamino, s-butylamino, t-butylamino, c-butylamino, 1-methyl-c-propylamino, 2-methyl-c-propylamino, n-pentylamino, 1-methyl-n-butylamino, 2-methyl-n-butylamino, 3-methyl-n-butylamino, 1,1-dimethyl-n-propylamino, 1,2-dimethyl-n-propylamino, 2,2-dimethyl-n-propylamino, 1-ethyl-n-propylamino, c-pentylamino, 1-methyl-c-butylamino, 2-methyl-c-butylamino, 3-methyl-c-butylamino, 1,2-dimethyl-c-propylamino, 2,3-dimethyl-c-propylamino, 1-ethyl-c-propylamino, 2-ethyl-c-propylamino, n-hexylamino, 1-methyl-n-pentylamino, 2-methyl-n-pentylamino, 3-methyl-n-pentylamino, 4-methyl-n-pentylamino, 1,1-dimethyl-n-butylamino, 1,2-dimethyl-n-butylamino, 1,3-dimethyl-n-butylamino, 2,2-dimethyl-n-butylamino, 2,3-dimethyl-n-butylamino, 3,3-dimethyl-n-butylamino, 1-ethyl-n-butylamino, 2-ethyl-n-butylamino, 1,1,2-trimethyl-n-propylamino, 1,2,2-trimethyl-n-propylamino, 1-ethyl-1-methyl-n-propylamino, 1-ethyl-2-methyl-n-propylamino, c-hexylamino, 1-methyl-c-pentylamino, 2-methyl-c-pentylamino, 3-methyl-c-pentylamino, 1-ethyl-c-butylamino, 2-ethyl-c-butylamino, 3-ethyl-c-butylamino, 1,2-dimethyl-c-butylamino, 1,3-dimethyl-c-butylamino, 2,2-dimethyl-c-butylamino, 2,3-dimethyl-c-butylamino, 2,4-dimethyl-c-butylamino, 3,3-dimethyl-c-butylamino, 1-n-propyl-c-propylamino, 2-n-propyl-c-propylamino, 1-i-propyl-c-propylamino, 2-i-propyl-c-propylamino, 1,2,2-trimethyl-c-propylamino, 1,2,3-trimethyl-c-propylamino, 2,2,3-trimethyl-c-propylamino, 1ethyl-2-methyl-c-propylamino, 2-ethyl-1-methyl-c-propylamino, 2-ethyl-2-methyl-c-propylamino, 2-ethyl-3-methyl-c-propylamino, 1-methyl-1-ethyl-n-pentylamino, 1-heptylamino, 2-heptylamino, 1-ethyl-1,2-dimethyl-n-propylamino, 1-ethyl-2,2-dimethyl-n-propylamino, 1-octylamino, 3-octylamino, 4-methyl-3-n-heptylamino, 6-methyl-2-n-heptylamino, 2-propyl-1-n-heptylamino, 2,4,4-trimethyl-1-n-pentylamino, 1-nonylamino, 2-nonylamino, 2,6-dimethyl-4-n-heptylamino, 3-ethyl-2,2-dimethyl-3-n-pentylamino, 3,5,5-trimethyl-1-n-hexylamino, 1-decylamino, 2-decylamino, 4-decylamino, 3,7-dimethyl-1-n-octylamino, 3,7-dimethyl-3-n-octylamino or the like may be mentioned.
A C1-10 dialkylamino group may be symmetric or asymmetric. A symmetric C1-10 dialkylamino group may be linear, branched or a C3-10 cycloalkylamino group, and dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-c-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, d-c-butylamino, di-(1-methyl-c-propyl)amino, di-(2-methyl-c-propyl)amino, di-n-pentylamino, di-(1-methyl-n-butyl)amino, di-(2-methyl-n-butyl)amino, di-(3-methyl-n-butyl)amino, di-(1,1-dimethyl-n-propyl)amino, di-(1,2-dimethyl-n-propyl)amino, di-(2,2-dimethyl-n-propyl)amino, di-(1-ethyl-n-propyl)amino, di-c-pentylamino, di-(1-methyl-c-butyl)amino, di-(2-methyl-c-butyl)amino, di-(3-methyl-c-butyl)amino, di-(1,2-dimethyl-c-propyl)amino, di-(2,3-dimethyl-c-propyl)amino, di-(1-ethyl-c-propyl)amino, di-(2-ethyl-c-propyl)amino, di-n-hexylamino, di-(1-methyl-n-pentyl)amino, di-(2-methyl-n-pentyl)amino, di-(3-methyl-n-pentyl)amino, di-(4-methyl-n-pentyl)amino, di-(1,1-dimethyl-n-butyl)amino, di-(1,2-dimethyl-n-butyl)amino, di-(1,3-dimethyl-n-butyl)amino, di-(2,2-dimethyl-n-butyl)amino, di-(2,3-dimethyl-n-butyl)amino, di-(3,3-dimethyl-n-butyl)amino, di-(1-ethyl-n-butyl)amino, di-(2-ethyl-n-butyl)amino, di-(1,1,2-trimethyl-n-propyl)amino, di-(1,2,2-trimethyl-n-propyl)amino, di-(1-ethyl-1-methyl-n-propyl)amino, di-(1-ethyl-2-methyl-n-propyl)amino, di-c-hexylamino, di-(1-methyl-c-pentyl)amino, di-(2-methyl-c-pentyl)amino, di-(3-methyl-c-pentyl)amino, di-(1-ethyl-c-butyl)amino, di-(2-ethyl-c-butyl)amino, di-(3-ethyl-c-butyl)amino, di-(1,2-dimethyl-c-butyl)amino, di-(1,3-dimethyl-c-butyl)amino, di-(2,2-dimethyl-c-butyl)amino, di-(2,3-dimethyl-c-butyl)amino, di-(2,4-dimethyl-c-butyl)amino, di-(3,3-dimethyl-c-butyl)amino, di-(1-n-propyl-c-propyl)amino, di-(2-n-propyl-c-propyl)amino, di-(1-i-propyl-c-propyl)amino, di-(2-i-propyl-c-propyl)amino, di-(1,2,2-trimethyl-c-propyl)amino, di-(1,2,3-trimethyl-c-propyl)amino, di-(2,2,3-trimethyl-c-propyl)amino, di-(1-ethyl-2-methyl-c-propyl)amino, di-(2-ethyl-1-methyl-c-propyl)amino, di-(2-ethyl-2-methyl-c-propyl)amino, di-(2-ethyl-3-methyl-c-propyl)amino, di-(1-methyl-1-ethyl-n-pentyl)amino, di-(1-heptyl)amino, di-(2-heptyl)amino, di-(1-ethyl-1,2-dimethyl-n-propyl)amino, di-(1-ethyl-2,2-dimethyl-n-propyl)amino, di-(1-octyl)amino, di-(3-octyl)amino, di-(4-methyl-3-n-heptyl)amino, di-(6-methyl-2-n-heptyl)amino, di-(2-propyl-1-n-heptyl)amino, di-(2,4,4-trimethyl-1-n-pentyl)amino, di-(1-nonyl)amino, di-(2-nonyl)amino, di-(2,6-dimethyl-4-n-heptyl)amino, di-(3-ethyl-2,2-dimethyl-3-n-pentyl)amino, di-(3,5,5-trimethyl-1-n-hexyl)amino, di-(1-decyl)amino, di-(2-decyl)amino, di-(4-decyl)amino, di-(3,7-dimethyl-1-n-octyl)amino, di-(3,7-dimethyl-3-n-octyl)amino or the like may be mentioned.
An asymmetric C1-10 dialkylamino group may be linear, branched or a C3-10 cycloalkylamino group, and (methyl, ethyl)amino, (methyl, n-propyl)amino, (methyl, i-propyl)amino, (methyl, c-propyl)amino, (methyl, n-butyl)amino, (methyl, i-butyl)amino, (methyl, s-butyl)amino, (methyl, t-butyl)amino, (methyl, n-pentyl)amino, (methyl, c-pentyl)amino, (methyl, n-hexyl)amino, (methyl, c-hexyl)amino, (ethyl, n-propyl)amino, (ethyl, i-propyl)amino, (ethyl, c-propyl)amino, (ethyl, n-butyl)amino, (ethyl, i-butyl)amino, (ethyl, s-butyl)amino, (ethyl, t-butyl)amino, (ethyl, n-pentyl)amino, (ethyl, c-pentyl)amino, (ethyl, n-hexyl)amino, (ethyl, c-hexyl)amino, (n-propyl, i-propyl)amino, (n-propyl, c-propyl)amino, (n-propyl, n-butyl)amino, (n-propyl, i-butyl)amino, (n-propyl, s-butyl)amino, (n-propyl, t-butyl)amino, (n-propyl, n-pentyl)amino, (n-propyl, c-pentyl)amino, (n-propyl, n-hexyl)amino, (n-propyl, c-hexyl)amino, (i-propyl, c-propyl)amino, (i-propyl, n-butyl)amino, (i-propyl, i-butyl)amino, (i-propyl, s-butyl)amino, (i-propyl, t-butyl)amino, (i-propyl, n-pentyl)amino, (i-propyl, c-pentyl)amino, (i-propyl, n-hexyl)amino, (i-propyl, c-hexyl)amino, (c-propyl, n-butyl)amino, (c-propyl, i-butyl)amino, (c-propyl, s-butyl)amino, (c-propyl, t-butyl)amino, (c-propyl, n-pentyl)amino, (c-propyl, c-pentyl)amino, (c-propyl, n-hexyl)amino, (c-propyl, c-hexyl)amino, (n-butyl, i-butyl)amino, (n-butyl, s-butyl)amino, (n-butyl, t-butyl)amino, (n-butyl, n-pentyl)amino, (n-butyl, c-pentyl)amino, (n-butyl, n-hexyl)amino, (n-butyl, c-hexyl)amino, (i-butyl, s-butyl)amino, (i-butyl, t-butyl)amino, (i-butyl, n-pentyl)amino, (i-butyl, c-pentyl)amino, (i-butyl, n-hexyl)amino, (i-butyl, c-hexyl)amino, (s-butyl, t-butyl)amino, (s-butyl, n-pentyl)amino, (s-butyl, c-pentyl)amino, (s-butyl, n-hexyl)amino, (s-butyl, c-hexyl)amino, (t-butyl, n-pentyl)amino, (t-butyl, c-pentyl)amino, (t-butyl, n-hexyl)amino, (t-butyl, c-hexyl)amino, (n-pentyl, c-pentyl)amino, (n-pentyl, n-hexyl)amino, (n-pentyl, c-hexyl)amino, (c-pentyl, n-hexyl)amino, (c-pentyl, c-hexyl)amino, (n-hexyl, c-hexyl)amino, (methyl, n-heptyl)amino, (methyl, n-octyl)amino, (methyl, n-nonanyl)amino, (methyl, n-decyl)amino, (methyl, n-heptyl)amino, (ethyl, n-octyl)amino, (ethyl, n-nonanyl)amino, (ethyl, n-decyl)amino or the like may be mentioned.
The protecting group in a protected hydroxyl group may be a C1-4 alkoxymethyl group (such as MOM: methoxymethyl, MEM: 2-methoxyethoxymethyl, ethoxymethyl, n-propoxymethyl, i-propoxymethyl, n-butoxymethyl, iBM: isobutyloxymethyl, BUM: t-butoxymethyl, POM: pivaloyloxymethyl, SEM: trimethylsilylethoxymethyl and the like, preferably a C1-2 alkoxymethyl or the like), an aryloxymethyl (such as BOM: benzyloxymethyl, PMBM: p-methoxybenzyloxymethyl, p-AOM: p-anisyloxymethyl and the like, preferably benzyloxymethyl or the like), a C1-4 alkylaminomethyl group (such as dimethylaminomethyl), a substituted acetamidomethyl group (such as Acm: acetamidomethyl, Tacm: trimethylacetamidemethyl and the like), a substituted thiomethyl group (such as MTM: methylthiomethyl, PTM: phenylthiomethyl, Btm: benzylthiomethyl and the like), a carboxyl group, a C1-7 acyl group (such as formyl, acetyl, fluoroacetyl, difluoroacetyl, trifluoroacetyl, chloroacetyl, dichloroacetyl, trichloroacetyl, propionyl, Pv: pivaloyl, tigloyl and the like), an arylcarbonyl group (such as benzoyl, benzoylformyl, benzoylpropionyl, phenylpropionyl and the like), a C1-4 alkoxycarbonyl group (such as methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, i-propoxycarbonyl, n-butoxycarbonyl, i-butoxycarbonyl, BOC: t-butoxycarbonyl, AOC: t-amyloxycarbonyl, VOC: vinyloxycarbonyl, AOC: allyloxycarbonyl, Teoc: 2-(trimethylsilyl)ethoxycarbonyl, Troc: 2,2,2-trichloroethoxycarbonyl and the like, preferably BOC and the like), an aryloxycarbonyl group (such as Z: benzyloxycarbonyl, p-nitrobenzyloxycarbonyl, MOZ: p-methoxybenzyloxycarbonyl and the like), a C1-4 alkylaminocarbonyl group (such as methylcarbamoyl, Ec: ethylcarbamoyl, n-propylcarbamoyl, and the like), an arylaminocarbonyl group (such as phenylcarbamoyl and the like), a trialkylsilyl group (such as TMS: trimethylsilyl, TES: triethylsilyl, TIPS: triisopropylsilyl, DEIPS: diethylisopropylsilyl, DMIPS: dimethylisopropylsilyl, DTBMS: di-t-butylmethylsilyl, IPDMS: isopropyldimethylsilyl, TBDMS: t-butyldimethylsilyl, TDS: thexyldimethylsilyl and the like, preferably t-butyldimethylsilyl and the like), a trialkylarylsilyl group (such as DPMS: diphenylmethylsilyl, TBDPS: t-butyldiphenylsilyl, TBMPS: t-butyldimethoxyphenylsilyl, TPS: triphenylsilyl and the like), an alkylsulfonyl group, (such as Ms: methanesulfonyl, ethanesulfonyl and the like) or an arylsulfonyl group (such as benzenesulfonyl, Ts: p-toluenesulfonyl, p-chlorobenzenesulfonyl, MBS: p-methoxybenzenesulfonyl, m-nitrobenzenesulfonyl, iMds: 2,6-dimethoxy-4-methylbenzenesulfonyl, Mds: 2,6-dimethyl-4-methoxybenzenesulfonyl, Mtb: 2,4,6-trimethoxybenzenesulfonyl, Mte: 2,3,5,6-tetramethyl-4-methoxybenzenesulfonyl, Mtr: 2,3,6-trimethyl-4-methoxybenzenesulfonyl, Mts: 2,4,6-trimethylbenzenesulfonyl, Pme: pentamethylbenzenesulfonyl and the like).
Specific preferred examples of the substituent R1 are a phenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group), furyl groups (a 2-furyl group and a 3-furyl group), pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group), quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolyl group, a 7-isoquinolyl group and a 8-isoquinolyl group) optionally substituted with one or more of the following substituents.
Substituents: a C1-10 alkyl group, a halogen atom, a C1-10 alkyl group substituted with one or more halogen atoms, a nitro group, an amino group, an amino group substituted with one or two C1-10 alkyl groups, an amino group substituted with a C1-10 alkylcarbonyl group, a thiol group substituted with a C1-10 alkyl group, a thiol group substituted with a C1-10 alkylcarbonyl group, a hydroxyl group, a C1-10 alkoxy group substituted with one or more halogen atoms, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group and a C1-10 alkylcarbonyl group.
Particularly preferred examples of the substituent R1 are a phenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group), furyl groups (a 2-furyl group and a 3-furyl group), pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group), quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolyl group, a 7-isoquinolyl group and a 8-isoquinolyl group) optionally substituted with one or more of the following substituents.
Substituents: a methyl group, a t-butyl group, a trifluoromethyl group, a trifluoromethoxy group, a bromine atom, a chlorine atom, a fluorine atom, a methoxy group, a methylamino group, a dimethylamino group, a t-butyloxy group and a t-butylamino group.
Still further preferred specific examples of the substituent are a 3-methyl-phenyl group, a 4-methyl-phenyl group, a 3,4-dimethyl-phenyl group, a 3-t-butyl-phenyl group, a 4-t-butyl-phenyl group, a 3-trifluoromethyl-phenyl group, a 4-trifluoromethyl-phenyl group, a 4-trifluoromethoxy-phenyl group, a 4-bromo-phenyl group, a 3,4-ditrifluoromethyl-phenyl group, a 3-chloro-phenyl group, a 4-chloro-phenyl group, a 3-fluoro-phenyl group, a 4-fluoro-phenyl group, a 3,4-dichloro-phenyl group, 3,4-difluoro-phenyl group, a 4-methoxy-phenyl group, a 4-methylamino-phenyl group, a 4-methyl-2-thienyl group, a 5-methyl-2-thienyl group, a 4,5-dimethyl-2-thienyl group, a 4-t-butyl-2-thienyl group, a S-t-butyl-2-thienyl group, a 4-trifluoromethyl-2-thienyl group, a 5-trifluoromethyl-2-thienyl group, a 4,5-ditrifluoromethyl-2-thienyl group, a 4-chloro-2-thienyl group, a 5-chloro-2-thienyl group, a 4-fluoro-2-thienyl group, a 5-fluoro-2-thienyl group, a 4,5-dichloro-2-thienyl group, 4,5-ditrifluoromethyl-2-thienyl group, a 5-methoxy-2-thienyl group, a 5-methylamino-2-thienyl group, a 4-methyl-2-furyl group, a 5-methyl-2-furyl group, a 4,5-dimethyl-2-furyl group, a 4-t-butyl-2-furyl group, a 5-t-butyl-2-furyl group, a 4-trifluoromethyl-2-furyl group, a 5-trifluoromethyl-2-furyl group, a 4,5-ditrifluoromethyl-2-furyl group, a 4-chloro-2-furyl group, a 5-chloro-2-furyl group, a 4-fluoro-2-furyl group, a 5-fluoro-2-furyl group, a 4,5-dichloro-2-furyl group, a 5-methoxy-2-furyl group, a 5-methylamino-2-furyl group, a 6-chloro-3-pyridazinyl group, a 6-methyl-3-pyridazinyl group, a 6-methoxy-3-pyridazinyl group, a 6-chloro-3-pyridazinyl group, a 6-methylpyridazinyl group, a 6-methoxy-3-pyridazinyl group, a 6-t-butoxy-3-pyridazinyl group, a 5,6-dimethyl-3-pyridazinyl group, a 5,6-dichloro-3-pyridazinyl group, a 6-t-butyl-3-pyridazinyl group, a 5-chloro-2-pyridyl group, a 5-trifluoromethyl-2-pyridyl group, a 5-methyl-2-pyridyl group, a 4,5-dimethyl-2-pyridyl group, a 5,6-dimethyl-2-pyridyl group, a 5-t-butyl-2-pyridyl group, a 4,5-dichloro-2-pyridyl group, a 5,6-dichloro-2-pyridyl group and the like.
Specific preferable examples of L1 are a bond, CH2, a oxygen atom, a sulfur atom, NH, N—Me, N—CHO, CHMe, CMe2, N—CH2Ph and the like, and particularly preferable examples are a bond, CH2, an oxygen atom, a sulfur atom, NH, NMe and the like.
Specific preferable examples of the substituent R2 are a hydrogen atom, a methyl group, an ethyl group, a n-propyl group, an i-propyl group, a t-butyl group, and a phenyl group (the methyl group, the ethyl group, the n-propyl group, the i-propyl group, the t-butyl group and the phenyl group may be optionally substituted with an amino group, a monomethylamino group, a dimethylamino group, a monoethylamino group, a diethylamino group, a methoxy group, an ethoxy group, a methoxycarbonyl group, an ethoxycarbonyl group, a methylcarbonyloxy group, an ethylcarbonyloxy group, a methylcarbonylamino group or an ethylcarbonylamino group and the like), and particularly preferable examples are a hydrogen atom, a methyl group, an ethyl group, a n-propyl group, an i-propyl group, a t-butyl group, a phenyl group and the like.
Specific preferable examples of L2 are a bond, CH2, a oxygen atom, a sulfur atom, NH, N—Me, N—CHO, CHMe, CMe2, N—CH2Ph and the like, and particularly preferable examples are a bond, CH2, an oxygen atom, a sulfur atom, NH, NMe and the like.
Specific preferable examples of L3 are a bond, CH2, an oxygen atom, a sulfur atom, NH, NH—OH, N—Me, N—CHO, CHMe, CMe2, N—CH2PH and the like, and particularly preferred examples are a bond, CH2, an oxygen atom, a sulfur atom, NH, NMe and the like.
Specific preferable examples of the substituent R3 are a phenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group), furyl groups (a 2-furyl group and a 3-furyl group), pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group), quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolyl group, a 7-isoquinolyl group and a 8-isoquinolyl group) optionally substituted with one or more of the following substituents.
Substituents: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a hydroxycarbamido group, a cyanocarbamido group, a sulfamido group, a hydroxysulfamido group, a cyanosulfamido group, a tetrazole group, —CH2CO2H, —OCH2CO2H, —NHCH2CO2H, —CH2CH2CO2H, an alkoxycarbonyl group and the following heterocyclic groups substituted with a hydroxyl group.
Heterocyclic groups: a 1,3,4-oxadiazole group, a 1,3,4-thiadiazole group, a 1,2,4-oxadiazole group, a 1,2,4-thiadiazole group, a 1,2,5-oxadiazole group, a 1,2,5-thiadiazole group, a 1,2-oxazole group and a 1,2-thiazole group.
Still further, specific preferable examples of the substituent R3 are a phenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group), furyl groups (a 2-furyl group and a 3-furyl group), pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group), quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolyl group, a 7-isoquinolyl group and a 8-isoquinolyl group) optionally substituted with one or more substituents optionally selected from substituent set A and with one or more substituents optionally selected from substituent set B.
Substituent set A: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid, a carbamido group, a hydroxycarbamido group, a cyanocarbamido group, a sulfamido group, a hydroxysulfamido group, a cyanosulfamido group, a tetrazole group, —CH2CO2H, —OCH2CO2H, —NHCH2CO2H, —CH2CH2CO2H and an alkoxycarbonyl group.
Substituent set B: an amino group, a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorines, a sulfamido group substituted with one or more C1-10 alkyl groups, a carbamido group substituted with one or more C1-10 alkyl groups and a C1-10 alkylcarbonylamino group.
Specific particularly preferable examples of the substituent R3 are a phenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group), furyl groups (a 2-furyl group and a 3-furyl group), pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group), quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinoyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolyl group, a 7-isoquinolyl group and a 8-isoquinolyl group) optionally substituted with one or more of the following substituents.
Substituents: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group, —CH2CO2H, —OCH2CO2H, —NHCH2CO2H and —CH2CH2CO2H.
Still further, specific particularly preferable examples of the substituent R3 are a phenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group), furyl groups (a 2-furyl group and a 3-furyl group), pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group), quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolyl group, a 7-isoquinolyl group and a 8-isoquinolyl group) optionally substituted with one or more substituents optionally selected from substituent set A and with one or more substituents optionally selected from substituent set B.
Substituent set A: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group, —CH2CO2H, —OCH2CO2H, —NHCH2CO2H and —CH2CH2CO2H.
Substituent set B: an amino group, a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or more C1-10 alkyl groups, a carbamido group substituted with one or more C1-10 alkyl groups and a C1-10 alkylcarbonylamino group.
Specific preferable examples of L4 are a bond, CH2, an oxygen atom, a sulfur atom, NH, N—Me, N—CHO, CHMe, CMe2, N—CH2Ph and the like, and particularly preferred examples are a single bond, CH2, an oxygen atom, a sulfur atom, NH, NMe and the like.
Specific preferable examples of X are OH, SH, NH2, OMe, SMe, NHMe, NHEt, NH—CHO, NH—CH2Ph, OCH2Ph, SCH2Ph, OC(═O)CH3, SC(═O)CH3, NC(═O)CH3 and the like, and particularly preferred examples are OH, SH, NH2 and the like Specific preferable examples of Y are an oxygen atom, a sulfur atom, NH, N—OH, N—CHO, N—Me, N—CH2Ph, N—OMe, N—OCH2Ph an the like, and particularly preferred examples are an oxygen atom, a sulfur atom, NH, N—OH and the like.
Favorable compounds as the thrombopoietin receptor activator, the preventive, therapeutic or improving agent for diseases against which activation of the thrombopoietin receptor is effective and the platelet increasing agent of the present invention are as follows.
1) Compounds represented by the formula (1) wherein A is a nitrogen atom, and B is a sulfur atom, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
2) Compounds represented by the formula (1) wherein  A is a nitrogen atom, and B is an oxygen atom, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
3) Compounds represented by the formula (1) wherein A is a nitrogen atom, and B is NR9 (wherein R9 is a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
4) Compounds represented by the formula (1) wherein A is CR4 (wherein R4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C2-6 alkenyl or a C2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a C1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2-6 alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group, a mono- or di-C1-10 alkylamino group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group, the mono- or di-C1-10 alkylamino group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 lo alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), or R6 and R7 mean, together with each other, —(CH2)m1-E-(CH2)m2— (wherein E is an oxygen atom, a sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom, a C1-10 alkyl group, a C2-14 aryl group, a C1-10 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR8 (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), and each of m1 and m2 is independently an integer of from 0 to 5 provided that m1+m2 is 3, 4 or 5)))), and B is a oxygen atom, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
5) Compounds represented by the formula (1) wherein A is CR4 (wherein R4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C2-6 alkenyl or a C2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a C1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2-6 alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group, a mono- or di-C1-10 alkylamino group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group, the mono- or di-C1-10 alkylamino group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), or R6 and R7 mean, together with each other, —(CH2)m1-E-(CH2)m2— (wherein E is an oxygen atom, a sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom, a C1-10 alkyl group, a C2-14 aryl group, a C1-10 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR8 (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), and each of m1 and m2 is independently an integer of from 0 to 5 provided that m1+m2 is 3, 4 or 5)))), and B is a sulfur atom, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
6) Compounds represented by the formula (1) wherein A is CR4 (wherein R4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C2-6 alkenyl or a C2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a C1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2-6 alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group, a mono- or di-C1-10 alkylamino group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group, the mono- or di-C1-10 alkylamino group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), or R6 and R7 mean, together with each other, —(CH2)m1-E-(CH2)m2— (wherein E is an oxygen atom, a sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom, a C1-10 alkyl group, a C2-14 aryl group, a C1-10 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR8 (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), and each of m1 and m2 is independently an integer of from 0 to 5 provided that m1+m2 is 3, 4 or 5)))), and B is NR9 (wherein R9 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
7) Compounds represented by the formula (1) according to 4), 5) or 6) wherein A is CR37 (wherein R37 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C2-6 alkenyl or a C2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a C1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2-6 alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxy group, a C1-10 alkylcarbonylamino group, a mono- or di-C1-10 alkylamino group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxy group, the C1-10 alkylcarbonylamino group and the mono- or di-C1-10 alkylamino group may be substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group and a cyano group), SO2R38, SOR38 or COR38 (wherein R38 is a hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkoxy group may be substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group and a cyano group), a C2-14 aryl group or a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. The terms in the respective substituents R37 and R38 are the same as those in the respective substituents R1 to R36.
8) Compounds represented by the formula (1) according to 3) or 6) wherein B is NR39 (wherein R39 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be substituted with one or more substituents selected from the group consisting of: a carboxyl group, a halogen atom, a nitro group and a cyano group), a C2-14 aryl group or a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group and a halogen atom)), tautomers prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. The terms in the substituent R39 are the same as those in the respective substituents R1 to R36.
9) Compounds represented by the formula (1) according to 1), 2), 3), 4), 5), 6), 7) or 8) wherein L1 is a bond, tautomers prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
10) Compounds represented by the formula (1) according to 1), 2), 3), 4), 5), 6), 7), 8) or 9) wherein L2 is a bond, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
11) Compounds represented by the formula (1) according to 1), 2), 3), 4), 5), 6), 7), 8), 9) or 10) wherein L3 is NR19 (wherein R19 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
12) The compounds according to 1), 2), 3), 4), 5), 6), 7), 8), 9) or 10) wherein L3 is NH, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
13) The compounds according to 1), 2), 3), 4), 5), 6), 7), 8), 9) or 10) wherein L3 is CH2, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
14) The compounds according to 11), 12) or 13) wherein L4 is a bond, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
15) The compounds according to 11), 12) or 13) wherein L4 is NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
16) The compounds according to 11), 12) or 13) wherein L4 is NH, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
17) The compounds according to 11), 12) or 13) wherein L4 is CH2, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
18) The compounds according to 14), 15), 16) or 17) wherein R2 is a hydrogen atom, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group and the C1-10 alkoxycarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcabonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C1-12 aryl group or a C2-14 aryloxy group (the C2-14 aryl group and C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
19) The compounds according to 14), 15), 16) or 17) wherein R2 is a hydrogen atom, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-3 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-3 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a phenyl group and a phenyloxy group (the phenyl group and the phenyloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a phenyl group or a phenyloxy group (the phenyl group and the phenyloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
20) The compounds according to 14), 15), 16) or 17) wherein R2 is a hydrogen atom, a C1-10 alkyl group, a C2-6 alkenyl group or a C2-6 alkynyl group (the C1-10 alkyl group, the C2-6 alkenyl group and the C2-6 alkynyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group and a protected hydroxyl group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
21) The compounds according to 14), 15), 16) or 17) wherein R2 is a hydrogen atom or a C1-6 alkyl group (the C1-6 alkyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group and a protected hydroxyl group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
22) The compounds according to 14), 15), 16) or 17) wherein R2 is a hydrogen atom or a C1-3 alkyl group (the C1-3 alkyl group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group and a protected hydroxyl group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
23) The compounds according to 18), 19), 20), 21) or 22) wherein R1 is a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group, OCHO, a cyano group, a hydroxyl group, a protected hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyloxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group, a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more substituents selected from the group consisting of: a C1-6 alkyl group (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms), a thiol group and an amino group (the thiol group and the amino group may be optionally substituted with one or more substituents selected from the group consisting of: a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group and a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
24) The compounds according to 18), 19), 20), 21) or 22) wherein R1 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group, OCHO, a cyano group, a hydroxyl group, a protected hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyloxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyl group, the C1-10 alkylcarbonyloxy group and the C1-10 alkoxycarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a thiol group and an amino (the thiol group and the amino group may be optionally substituted with one or more substituents selected from the group consisting of: a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group and a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
25) The compounds according to 18), 19), 20), 21) or 22) wherein R1 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group, OCHO, a cyano group, a hydroxyl group, a protected hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyloxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyl group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group and a cyano group), a C2-14 aryl group, a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms), a thiol group and an amino group (the thiol group and the amino group may be optionally substituted with one or more substituents selected from the group consisting of: a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group and a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group, a cyano group, a hydroxyl group and a protected hydroxyl group))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
26) The compounds according to 18), 19), 20), 21) or 22) wherein R1 is a phenyl group (the phenyl group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group, OCHO, a cyano group, a hydroxyl group, a protected hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyloxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyl group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a thiol group and an amino group (the thiol group and the amino group may be optionally substituted with one or more substituents selected from the group consisting of: a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group and a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
27) The compounds according to 18), 19), 20), 21) or 22) wherein R1 is a phenyl group (the phenyl group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group, OCHO, a cyano group, a hydroxyl group, a protected hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyloxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyl group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group and a cyano group), a C2-14 aryl group, a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms), a thiol group and an amino group (the thiol group and the amino group may be optionally substituted with one or more substituents selected from the group consisting of: a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group and a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group, a cyano group, a hydroxyl group and a protected hydroxyl group))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
28) The compounds according to 23), 24), 25), 26) or 27) wherein Y is an oxygen atom, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
29) The compounds according to 23), 24), 25), 26) or 27) wherein Y is a sulfur atom, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
30) The compounds according to 28) or 29) wherein X is a hydroxyl group, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
31) The compounds according to 28), 29) or 30) wherein R3 is a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a hydroxycarbamido group, a hydroxysulfamido group, a tetrazole group, a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or more C1-10 alkyl groups, a carbamido group substituted with one or more C1-10 alkyl groups, a C1-10 alkoxycarbonyl group, a C1-10 alkoxy group, a C1-10 alkyl group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group (the C1-10 alkoxycarbonyl group, the C1-10 alkoxy group, the C1-10 alkyl group, the C1-10 alkylcarbonyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group and the mono- or di-C1-10 alkylamino group may be optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a mono- or di-C1-10 alkylamino group, a carboxyl group, a nitro group, a cyano group and a halogen atom)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
32) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group may be optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a hydroxycarbamido group, a hydroxysulfamido group, a tetrazole group, a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or more C1-10 alkyl groups, a carbamido group substituted with one or more C1-10 alkyl groups, a C1-10 alkoxycarbonyl group, a C1-10 alkoxy group, a C1-10 alkyl group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group (the C1-10 alkoxycarbonyl group, the C1-10 alkoxy group, the C1-10 alkyl group, the C1-10 alkylcarbonyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group and the mono- or di-C1-10 alkylamino group may be optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a mono- or di-C1-10 alkylamino group, a carboxyl group, a nitro group, a cyano group and a halogen atom)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
33) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group (the phenyl group may be optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a hydroxycarbamido group, a hydroxysulfamido group, a tetrazole group, a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or more C1-10 alkyl groups, a carbamido group substituted with one or more C1-10 alkyl groups, a C1-10 alkoxycarbonyl group, a C1-10 alkoxy group, a C1-10 alkyl group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group (the C1-10 alkoxycarbonyl group, the C1-10 alkoxy group, the C1-10 alkyl group, the C1-10 alkylcarbonyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group and the mono- or di-C1-10 alkylamino group may be optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a mono- or di-C1-10 alkylamino group, a carboxyl group, a nitro group, a cyano group and a halogen atom)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
34) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a hydroxycarbamido group, a hydroxysulfamido group, a tetrazole group, a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or more C1-10 alkyl groups, a carbamido group substituted with one or more C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
35) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group (the phenyl group is optionally substituted with a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a hydroxycarbamido group, a hydroxysulfamido group or a tetrazole group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
36) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with a carboxyl group, a phosphonic acid group, a sulfonic acid group or a tetrazole group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
37) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group (the phenyl group is optionally substituted with a carboxyl group, a phosphonic acid group, a sulfonic acid group or a tetrazole group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
38) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are substituted with a carboxyl group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
39) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group substituted with a carboxyl group, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
40) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with a sulfonic acid group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
41) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group substituted with a sulfonic acid group, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
42) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a pyridyl group, a thienyl group, a furyl group, a pyridazinyl group, a 1,3,4-oxadiazole group, a 1,3,4-thiadiazole group, a 1,2,4-oxadiazole group, a 1,2,4-thiadiazole group, a 1,2,5-oxadiazole group, a 1,2,5-thiadiazole group, a 1,2-oxazole group, a 1,2-thiazole group, a quinolyl group or an isoquinolyl group (the phenyl group, the pyridyl group, the thienyl group, the furyl group, the pyridazinyl group, the 1,3,4-oxadiazole group, the 1,3,4-thiadiazole group, the 1,2,4-oxadiazole group, the 1,2,4-thiadiazole group, the 1,2,5-oxadiazole group, the 1,2,5-thiadiazole group, the 1,2-oxazole group, the 1,2-thiazole group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more hydroxyl groups), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
43) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a pyridyl group, a thienyl group, a furyl group, a pyridazinyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the pyridyl group, the thienyl group, the furyl group, the pyridazinyl group, the quinolyl group and the isoquinolyl group are optionally substituted with an azole group optionally substituted with one or more hydroxyl groups (the azole group is a 1,3,4-oxadiazole group, a 1,3,4-thiadiazole group, a 1,2,4-oxadiazole group, a 1,2,4-thiadiazole group, a 1,2,5-oxadiazole group, a 1,2,5-thiadiazole group, a 1,2-oxazole group or a 1,2-thiazole group)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
44) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more —CH2CO2H groups), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
45) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group substituted with one or more —CH2CO2H groups, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
46) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group, (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are substituted with one or more —OCH2CO2H groups) tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
47) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group substituted with one or more —OCH2CO2H groups, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
48) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are substituted with one or more —NHCH2CO2H groups), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
49) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group substituted with one or more —NHCH2CO2H groups, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
50) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are substituted with one or more —CH2CH2CO2H groups), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
51) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group substituted with one or more —CH2CH2CO2H groups, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
52) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group (the phenyl group is optionally substituted with one or more substituents optionally selected from the group consisting of:
a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a hydroxycarbamido group, a hydroxysulfamido group and a tetrazole group
and a substituent optionally selected from the group consisting of:
a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
53) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more substituents selected from the group consisting of:
a carboxyl group, a phosphonic acid group, a sulfonic acid group and a tetrazole group
and one or more substituents optionally selected from the group consisting of:
a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
54) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group (the phenyl group is optionally substituted with one or more substituents selected from the group consisting of:
a carboxyl group, a phosphonic acid group, a sulfonic acid group and a tetrazole group
and one or more substituents optionally selected from the group consisting of:
a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
55) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are substituted with a carboxyl group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
56) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group substituted with a carboxyl group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
57) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with a sulfonic acid group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
58) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group substituted with a sulfonic acid group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
59) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a pyridyl group, a thienyl group, a furyl group, a pyridazinyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the pyridyl group, the thienyl group, the furyl group, the pyridazinyl group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more hydroxyl groups and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
60) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with a —CH2CO2H group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
61) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group substituted with a —CH2CO2H group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
62) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are substituted with a —OCH2CO2H group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
63) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group substituted with a —OCH2CO2H group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
64) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are substituted with a —NHCH2CO2H group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
65) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group substituted with a —NHCH2CO2H group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
66) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are substituted with a —CH2CH2CO2H group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
67) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group substituted with a —CH2CH2CO2H group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
68) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.


















TABLE 1





No
A
B
R1
L1
R2
L2
L3
Y
L4
R3
X


























1
N
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3a
OH


2
N
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3b
OH


3
N
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3c
OH


4
N
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
Q3a
OH


5
N
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
Q3b
OH


6
N
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
Q3c
OH


7
N
NMe
Q1a
a bond
Me
a bond
NH
O
NH
Q3a
OH


8
N
NMe
Q1a
a bond
Me
a bond
NH
O
NH
Q3b
OH


9
N
NMe
Q1a
a bond
Me
a bond
NH
O
NH
Q3c
OH


10
N
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3a
OH


11
N
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3b
OH


12
N
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3c
OH


13
N
NMe
Q1a
a bond
H
a bond
NH
S
NH
Q3a
OH


14
N
NMe
Q1a
a bond
H
a bond
NH
S
NH
Q3b
OH


15
N
NMe
Q1a
a bond
H
a bond
NH
S
NH
Q3c
OH


16
N
NMe
Q1a
a bond
H
a bond
NH
S
a bond
Q3a
OH


17
N
NMe
Q1a
a bond
H
a bond
NH
S
a bond
Q3b
OH


18
N
NMe
Q1a
a bond
H
a bond
NH
S
a bond
Q3c
OH


19
N
NMe
Q1a
a bond
H
a bond
NH
O
NH
Q3a
OH


20
N
NMe
Q1a
a bond
H
a bond
NH
O
NH
Q3b
OH


21
N
NMe
Q1a
a bond
H
a bond
NH
O
NH
Q3c
OH


22
N
NMe
Q1a
a bond
H
a bond
NH
O
a bond
Q3a
OH


23
N
NMe
Q1a
a bond
H
a bond
NH
O
a bond
Q3b
OH


24
N
NMe
Q1a
a bond
H
a bond
NH
O
a bond
Q3c
OH


25
N
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3a
OH


26
N
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3b
OH


27
N
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3c
OH


28
N
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
Q3a
OH


29
N
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
Q3b
OH


30
N
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
Q3c
OH


31
N
NMe
Q1b
a bond
Me
a bond
NH
O
NH
Q3a
OH


32
N
NMe
Q1b
a bond
Me
a bond
NH
O
NH
Q3b
OH


33
N
NMe
Q1b
a bond
Me
a bond
NH
O
NH
Q3c
OH


34
N
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3a
OH


35
N
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3b
OH


36
N
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3c
OH


37
N
NMe
Q1b
a bond
H
a bond
NH
S
NH
Q3a
OH


38
N
NMe
Q1b
a bond
H
a bond
NH
S
NH
Q3b
OH


39
N
NMe
Q1b
a bond
H
a bond
NH
S
NH
Q3c
OH


40
N
NMe
Q1b
a bond
H
a bond
NH
S
a bond
Q3a
OH


41
N
NMe
Q1b
a bond
H
a bond
NH
S
a bond
Q3b
OH


42
N
NMe
Q1b
a bond
H
a bond
NH
S
a bond
Q3c
OH


43
N
NMe
Q1b
a bond
H
a bond
NH
O
NH
Q3a
OH


44
N
NMe
Q1b
a bond
H
a bond
NH
O
NH
Q3b
OH


45
N
NMe
Q1b
a bond
H
a bond
NH
O
NH
Q3c
OH


46
N
NMe
Q1b
a bond
H
a bond
NH
O
a bond
Q3a
OH


47
N
NMe
Q1b
a bond
H
a bond
NH
O
a bond
Q3b
OH


48
N
NMe
Q1b
a bond
H
a bond
NH
O
a bond
Q3c
OH


49
N
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3a
OH


50
N
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3b
OH


51
N
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3c
OH


52
N
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
Q3a
OH


53
N
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
Q3b
OH


54
N
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
Q3c
OH


55
N
NMe
Q1c
a bond
Me
a bond
NH
O
NH
Q3a
OH


56
N
NMe
Q1c
a bond
Me
a bond
NH
O
NH
Q3b
OH


57
N
NMe
Q1c
a bond
Me
a bond
NH
O
NH
Q3c
OH


58
N
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
Q3a
OH


59
N
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
Q3b
OH


60
N
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
Q3c
OH


61
N
NMe
Q1c
a bond
H
a bond
NH
S
NH
Q3a
OH


62
N
NMe
Q1c
a bond
H
a bond
NH
S
NH
Q3b
OH


63
N
NMe
Q1c
a bond
H
a bond
NH
S
NH
Q3c
OH


64
N
NMe
Q1c
a bond
H
a bond
NH
S
a bond
Q3a
OH


65
N
NMe
Q1c
a bond
H
a bond
NH
S
a bond
Q3b
OH


66
N
NMe
Q1c
a bond
H
a bond
NH
S
a bond
Q3c
OH


67
N
NMe
Q1c
a bond
H
a bond
NH
O
NH
Q3a
OH


68
N
NMe
Q1c
a bond
H
a bond
NH
O
NH
Q3b
OH


69
N
NMe
Q1c
a bond
H
a bond
NH
O
NH
Q3c
OH


70
N
NMe
Q1c
a bond
H
a bond
NH
O
a bond
Q3a
OH


71
N
NMe
Q1c
a bond
H
a bond
NH
O
a bond
Q3b
OH


72
N
NMe
Q1c
a bond
H
a bond
NH
O
a bond
Q3c
OH


73
N
NMe
Q1d
a bond
Me
a bond
NH
S
NH
Q3a
OH


74
N
NMe
Q1d
a bond
Me
a bond
NH
S
NH
Q3b
OH


75
N
NMe
Q1d
a bond
Me
a bond
NH
S
NH
Q3c
OH


76
N
NMe
Q1d
a bond
Me
a bond
NH
S
a bond
Q3a
OH


77
N
NMe
Q1d
a bond
Me
a bond
NH
S
a bond
Q3b
OH


78
N
NMe
Q1d
a bond
Me
a bond
NH
S
a bond
Q3c
OH


79
N
NMe
Q1d
a bond
Me
a bond
NH
O
NH
Q3a
OH


80
N
NMe
Q1d
a bond
Me
a bond
NH
O
NH
Q3b
OH


81
N
NMe
Q1d
a bond
Me
a bond
NH
O
NH
Q3c
OH


82
N
NMe
Q1d
a bond
Me
a bond
NH
O
a bond
Q3a
OH


83
N
NMe
Q1d
a bond
Me
a bond
NH
O
a bond
Q3b
OH


84
N
NMe
Q1d
a bond
Me
a bond
NH
O
a bond
Q3c
OH


85
N
NMe
Q1d
a bond
H
a bond
NH
S
NH
Q3a
OH


86
N
NMe
Q1d
a bond
H
a bond
NH
S
NH
Q3b
OH


87
N
NMe
Q1d
a bond
H
a bond
NH
S
NH
Q3c
OH


88
N
NMe
Q1d
a bond
H
a bond
NH
S
a bond
Q3a
OH


89
N
NMe
Q1d
a bond
H
a bond
NH
S
a bond
Q3b
OH


90
N
NMe
Q1d
a bond
H
a bond
NH
S
a bond
Q3c
OH


91
N
NMe
Q1d
a bond
H
a bond
NH
O
NH
Q3a
OH


92
N
NMe
Q1d
a bond
H
a bond
NH
O
NH
Q3b
OH


93
N
NMe
Q1d
a bond
H
a bond
NH
O
NH
Q3c
OH


94
N
NMe
Q1d
a bond
H
a bond
NH
O
a bond
Q3a
OH


95
N
NMe
Q1d
a bond
H
a bond
NH
O
a bond
Q3b
OH


96
N
NMe
Q1d
a bond
H
a bond
NH
O
a bond
Q3c
OH


97
N
NMe
Q1e
a bond
Me
a bond
NH
S
NH
Q3a
OH


98
N
NMe
Q1e
a bond
Me
a bond
NH
S
NH
Q3b
OH


99
N
NMe
Q1e
a bond
Me
a bond
NH
S
NH
Q3c
OH


100
N
NMe
Q1e
a bond
Me
a bond
NH
S
a bond
Q3a
OH


101
N
NMe
Q1e
a bond
Me
a bond
NH
S
a bond
Q3b
OH


102
N
NMe
Q1e
a bond
Me
a bond
NH
S
a bond
Q3c
OH


103
N
NMe
Q1e
a bond
Me
a bond
NH
O
NH
Q3a
OH


104
N
NMe
Q1e
a bond
Me
a bond
NH
O
NH
Q3b
OH


105
N
NMe
Q1e
a bond
Me
a bond
NH
O
NH
Q3c
OH


106
N
NMe
Q1e
a bond
Me
a bond
NH
O
a bond
Q3a
OH


107
N
NMe
Q1e
a bond
Me
a bond
NH
O
a bond
Q3b
OH


108
N
NMe
Q1e
a bond
Me
a bond
NH
O
a bond
Q3c
OH


109
N
NMe
Q1e
a bond
H
a bond
NH
S
NH
Q3a
OH


110
N
NMe
Q1e
a bond
H
a bond
NH
S
NH
Q3b
OH


111
N
NMe
Q1e
a bond
H
a bond
NH
S
NH
Q3c
OH


112
N
NMe
Q1e
a bond
H
a bond
NH
S
a bond
Q3a
OH


113
N
NMe
Q1e
a bond
H
a bond
NH
S
a bond
Q3b
OH


114
N
NMe
Q1e
a bond
H
a bond
NH
S
a bond
Q3c
OH


115
N
NMe
Q1e
a bond
H
a bond
NH
O
NH
Q3a
OH


116
N
NMe
Q1e
a bond
H
a bond
NH
O
NH
Q3b
OH


117
N
NMe
Q1e
a bond
H
a bond
NH
O
NH
Q3c
OH


118
N
NMe
Q1e
a bond
H
a bond
NH
O
a bond
Q3a
OH


119
N
NMe
Q1e
a bond
H
a bond
NH
O
a bond
Q3b
OH


120
N
NMe
Q1e
a bond
H
a bond
NH
O
a bond
Q3c
OH


121
N
NMe
Q1f
a bond
Me
a bond
NH
S
NH
Q3a
OH


122
N
NMe
Q1f
a bond
Me
a bond
NH
S
NH
Q3b
OH


123
N
NMe
Q1f
a bond
Me
a bond
NH
S
NH
Q3c
OH


124
N
NMe
Q1f
a bond
Me
a bond
NH
S
a bond
Q3a
OH


125
N
NMe
Q1f
a bond
Me
a bond
NH
S
a bond
Q3b
OH


126
N
NMe
Q1f
a bond
Me
a bond
NH
S
a bond
Q3c
OH


127
N
NMe
Q1f
a bond
Me
a bond
NH
O
NH
Q3a
OH


128
N
NMe
Q1f
a bond
Me
a bond
NH
O
NH
Q3b
OH


129
N
NMe
Q1f
a bond
Me
a bond
NH
O
NH
Q3c
OH


130
N
NMe
Q1f
a bond
Me
a bond
NH
O
a bond
Q3a
OH


131
N
NMe
Q1f
a bond
Me
a bond
NH
O
a bond
Q3b
OH


132
N
NMe
Q1f
a bond
Me
a bond
NH
O
a bond
Q3c
OH


133
N
NMe
Q1f
a bond
H
a bond
NH
S
NH
Q3a
OH


134
N
NMe
Q1f
a bond
H
a bond
NH
S
NH
Q3b
OH


135
N
NMe
Q1f
a bond
H
a bond
NH
S
NH
Q3c
OH


136
N
NMe
Q1f
a bond
H
a bond
NH
S
a bond
Q3a
OH


137
N
NMe
Q1f
a bond
H
a bond
NH
S
a bond
Q3b
OH


138
N
NMe
Q1f
a bond
H
a bond
NH
S
a bond
Q3c
OH


139
N
NMe
Q1f
a bond
H
a bond
NH
O
NH
Q3a
OH


140
N
NMe
Q1f
a bond
H
a bond
NH
O
NH
Q3b
OH


141
N
NMe
Q1f
a bond
H
a bond
NH
O
NH
Q3c
OH


142
N
NMe
Q1f
a bond
H
a bond
NH
O
a bond
Q3a
OH


143
N
NMe
Q1f
a bond
H
a bond
NH
O
a bond
Q3b
OH


144
N
NMe
Q1f
a bond
H
a bond
NH
O
a bond
Q3c
OH


145
N
NMe
Q1g
a bond
Me
a bond
NH
S
NH
Q3a
OH


146
N
NMe
Q1g
a bond
Me
a bond
NH
S
NH
Q3b
OH


147
N
NMe
Q1g
a bond
Me
a bond
NH
S
NH
Q3c
OH


148
N
NMe
Q1g
a bond
Me
a bond
NH
S
a bond
Q3a
OH


149
N
NMe
Q1g
a bond
Me
a bond
NH
S
a bond
Q3b
OH


150
N
NMe
Q1g
a bond
Me
a bond
NH
S
a bond
Q3c
OH


151
N
NMe
Q1g
a bond
Me
a bond
NH
O
NH
Q3a
OH


152
N
NMe
Q1g
a bond
Me
a bond
NH
O
NH
Q3b
OH


153
N
NMe
Q1g
a bond
Me
a bond
NH
O
NH
Q3c
OH


154
N
NMe
Q1g
a bond
Me
a bond
NH
O
a bond
Q3a
OH


155
N
NMe
Q1g
a bond
Me
a bond
NH
O
a bond
Q3b
OH


156
N
NMe
Q1g
a bond
Me
a bond
NH
O
a bond
Q3c
OH


157
N
NMe
Q1g
a bond
H
a bond
NH
S
NH
Q3a
OH


158
N
NMe
Q1g
a bond
H
a bond
NH
S
NH
Q3b
OH


159
N
NMe
Q1g
a bond
H
a bond
NH
S
NH
Q3c
OH


160
N
NMe
Q1g
a bond
H
a bond
NH
S
a bond
Q3a
OH


161
N
NMe
Q1g
a bond
H
a bond
NH
S
a bond
Q3b
OH


162
N
NMe
Q1g
a bond
H
a bond
NH
S
a bond
Q3c
OH


163
N
NMe
Q1g
a bond
H
a bond
NH
O
NH
Q3a
OH


164
N
NMe
Q1g
a bond
H
a bond
NH
O
NH
Q3b
OH


165
N
NMe
Q1g
a bond
H
a bond
NH
O
NH
Q3c
OH


166
N
NMe
Q1g
a bond
H
a bond
NH
O
a bond
Q3a
OH


167
N
NMe
Q1g
a bond
H
a bond
NH
O
a bond
Q3b
OH


168
N
NMe
Q1g
a bond
H
a bond
NH
O
a bond
Q3c
OH


169
N
NMe
Q1h
a bond
Me
a bond
NH
S
NH
Q3a
OH


170
N
NMe
Q1h
a bond
Me
a bond
NH
S
NH
Q3b
OH


171
N
NMe
Q1h
a bond
Me
a bond
NH
S
NH
Q3c
OH


172
N
NMe
Q1h
a bond
Me
a bond
NH
S
a bond
Q3a
OH


173
N
NMe
Q1h
a bond
Me
a bond
NH
S
a bond
Q3b
OH


174
N
NMe
Q1h
a bond
Me
a bond
NH
S
a bond
Q3c
OH


175
N
NMe
Q1h
a bond
Me
a bond
NH
O
NH
Q3a
OH


176
N
NMe
Q1h
a bond
Me
a bond
NH
O
NH
Q3b
OH


177
N
NMe
Q1h
a bond
Me
a bond
NH
O
NH
Q3c
OH


178
N
NMe
Q1h
a bond
Me
a bond
NH
O
a bond
Q3a
OH


179
N
NMe
Q1h
a bond
Me
a bond
NH
O
a bond
Q3b
OH


180
N
NMe
Q1h
a bond
Me
a bond
NH
O
a bond
Q3c
OH


181
N
NMe
Q1h
a bond
H
a bond
NH
S
NH
Q3a
OH


182
N
NMe
Q1h
a bond
H
a bond
NH
S
NH
Q3b
OH


183
N
NMe
Q1h
a bond
H
a bond
NH
S
NH
Q3c
OH


184
N
NMe
Q1h
a bond
H
a bond
NH
S
a bond
Q3a
OH


185
N
NMe
Q1h
a bond
H
a bond
NH
S
a bond
Q3b
OH


186
N
NMe
Q1h
a bond
H
a bond
NH
S
a bond
Q3c
OH


187
N
NMe
Q1h
a bond
H
a bond
NH
O
NH
Q3a
OH


188
N
NMe
Q1h
a bond
H
a bond
NH
O
NH
Q3b
OH


189
N
NMe
Q1h
a bond
H
a bond
NH
O
NH
Q3c
OH


190
N
NMe
Q1h
a bond
H
a bond
NH
O
a bond
Q3a
OH


191
N
NMe
Q1h
a bond
H
a bond
NH
O
a bond
Q3b
OH


192
N
NMe
Q1h
a bond
H
a bond
NH
O
a bond
Q3c
OH


193
N
NMe
Q1i
a bond
Me
a bond
NH
S
NH
Q3a
OH


194
N
NMe
Q1i
a bond
Me
a bond
NH
S
NH
Q3b
OH


195
N
NMe
Q1i
a bond
Me
a bond
NH
S
NH
Q3c
OH


196
N
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
Q3a
OH


197
N
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
Q3b
OH


198
N
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
Q3c
OH


199
N
NMe
Q1i
a bond
Me
a bond
NH
O
NH
Q3a
OH


200
N
NMe
Q1i
a bond
Me
a bond
NH
O
NH
Q3b
OH


201
N
NMe
Q1i
a bond
Me
a bond
NH
O
NH
Q3c
OH


202
N
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
Q3a
OH


203
N
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
Q3b
OH


204
N
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
Q3c
OH


205
N
NMe
Q1i
a bond
H
a bond
NH
S
NH
Q3a
OH


206
N
NMe
Q1i
a bond
H
a bond
NH
S
NH
Q3b
OH


207
N
NMe
Q1i
a bond
H
a bond
NH
S
NH
Q3c
OH


208
N
NMe
Q1i
a bond
H
a bond
NH
S
a bond
Q3a
OH


209
N
NMe
Q1i
a bond
H
a bond
NH
S
a bond
Q3b
OH


210
N
NMe
Q1i
a bond
H
a bond
NH
S
a bond
Q3c
OH


211
N
NMe
Q1i
a bond
H
a bond
NH
O
NH
Q3a
OH


212
N
NMe
Q1i
a bond
H
a bond
NH
O
NH
Q3b
OH


213
N
NMe
Q1i
a bond
H
a bond
NH
O
NH
Q3c
OH


214
N
NMe
Q1i
a bond
H
a bond
NH
O
a bond
Q3a
OH


215
N
NMe
Q1i
a bond
H
a bond
NH
O
a bond
Q3b
OH


216
N
NMe
Q1i
a bond
H
a bond
NH
O
a bond
Q3c
OH


217
N
NMe
Q1j
a bond
Me
a bond
NH
S
NH
Q3a
OH


218
N
NMe
Q1j
a bond
Me
a bond
NH
S
NH
Q3b
OH


219
N
NMe
Q1j
a bond
Me
a bond
NH
S
NH
Q3c
OH


220
N
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
Q3a
OH


221
N
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
Q3b
OH


222
N
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
Q3c
OH


223
N
NMe
Q1j
a bond
Me
a bond
NH
O
NH
Q3a
OH


224
N
NMe
Q1j
a bond
Me
a bond
NH
O
NH
Q3b
OH


225
N
NMe
Q1j
a bond
Me
a bond
NH
O
NH
Q3c
OH


226
N
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
Q3a
OH


227
N
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
Q3b
OH


228
N
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
Q3c
OH


229
N
NMe
Q1j
a bond
H
a bond
NH
S
NH
Q3a
OH


230
N
NMe
Q1j
a bond
H
a bond
NH
S
NH
Q3b
OH


231
N
NMe
Q1j
a bond
H
a bond
NH
S
NH
Q3c
OH


232
N
NMe
Q1j
a bond
H
a bond
NH
S
a bond
Q3a
OH


233
N
NMe
Q1j
a bond
H
a bond
NH
S
a bond
Q3b
OH


234
N
NMe
Q1j
a bond
H
a bond
NH
S
a bond
Q3c
OH


235
N
NMe
Q1j
a bond
H
a bond
NH
O
NH
Q3a
OH


236
N
NMe
Q1j
a bond
H
a bond
NH
O
NH
Q3b
OH


237
N
NMe
Q1j
a bond
H
a bond
NH
O
NH
Q3c
OH


238
N
NMe
Q1j
a bond
H
a bond
NH
O
a bond
Q3a
OH


239
N
NMe
Q1j
a bond
H
a bond
NH
O
a bond
Q3b
OH


240
N
NMe
Q1j
a bond
H
a bond
NH
O
a bond
Q3c
OH


241
N
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3a
OH


242
N
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3b
OH


243
N
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3c
OH


244
N
NEt
Q1a
a bond
Me
a bond
NH
S
a bond
Q3a
OH


245
N
NEt
Q1a
a bond
Me
a bond
NH
S
a bond
Q3b
OH


246
N
NEt
Q1a
a bond
Me
a bond
NH
S
a bond
Q3c
OH


247
N
NEt
Q1a
a bond
Me
a bond
NH
O
NH
Q3a
OH


248
N
NEt
Q1a
a bond
Me
a bond
NH
O
NH
Q3b
OH


249
N
NEt
Q1a
a bond
Me
a bond
NH
O
NH
Q3c
OH


250
N
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3a
OH


251
N
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3b
OH


252
N
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3c
OH


253
N
NEt
Q1a
a bond
H
a bond
NH
S
NH
Q3a
OH


254
N
NEt
Q1a
a bond
H
a bond
NH
S
NH
Q3b
OH


255
N
NEt
Q1a
a bond
H
a bond
NH
S
NH
Q3c
OH


256
N
NEt
Q1a
a bond
H
a bond
NH
S
a bond
Q3a
OH


257
N
NEt
Q1a
a bond
H
a bond
NH
S
a bond
Q3b
OH


258
N
NEt
Q1a
a bond
H
a bond
NH
S
a bond
Q3c
OH


259
N
NEt
Q1a
a bond
H
a bond
NH
O
NH
Q3a
OH


260
N
NEt
Q1a
a bond
H
a bond
NH
O
NH
Q3b
OH


261
N
NEt
Q1a
a bond
H
a bond
NH
O
NH
Q3c
OH


262
N
NEt
Q1a
a bond
H
a bond
NH
O
a bond
Q3a
OH


263
N
NEt
Q1a
a bond
H
a bond
NH
O
a bond
Q3b
OH


264
N
NEt
Q1a
a bond
H
a bond
NH
O
a bond
Q3c
OH


265
N
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3a
OH


266
N
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3b
OH


267
N
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3c
OH


268
N
NEt
Q1b
a bond
Me
a bond
NH
S
a bond
Q3a
OH


269
N
NEt
Q1b
a bond
Me
a bond
NH
S
a bond
Q3b
OH


270
N
NEt
Q1b
a bond
Me
a bond
NH
S
a bond
Q3c
OH


271
N
NEt
Q1b
a bond
Me
a bond
NH
O
NH
Q3a
OH


272
N
NEt
Q1b
a bond
Me
a bond
NH
O
NH
Q3b
OH


273
N
NEt
Q1b
a bond
Me
a bond
NH
O
NH
Q3c
OH


274
N
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3a
OH


275
N
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3b
OH


276
N
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3c
OH


277
N
NEt
Q1b
a bond
H
a bond
NH
S
NH
Q3a
OH


278
N
NEt
Q1b
a bond
H
a bond
NH
S
NH
Q3b
OH


279
N
NEt
Q1b
a bond
H
a bond
NH
S
NH
Q3c
OH


280
N
NEt
Q1b
a bond
H
a bond
NH
S
a bond
Q3a
OH


281
N
NEt
Q1b
a bond
H
a bond
NH
S
a bond
Q3b
OH


282
N
NEt
Q1b
a bond
H
a bond
NH
S
a bond
Q3c
OH


283
N
NEt
Q1b
a bond
H
a bond
NH
O
NH
Q3a
OH


284
N
NEt
Q1b
a bond
H
a bond
NH
O
NH
Q3b
OH


285
N
NEt
Q1b
a bond
H
a bond
NH
O
NH
Q3c
OH


286
N
NEt
Q1b
a bond
H
a bond
NH
O
a bond
Q3a
OH


287
N
NEt
Q1b
a bond
H
a bond
NH
O
a bond
Q3b
OH


288
N
NEt
Q1b
a bond
H
a bond
NH
O
a bond
Q3c
OH


289
N
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3a
OH


290
N
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3b
OH


291
N
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3c
OH


292
N
NEt
Q1c
a bond
Me
a bond
NH
S
a bond
Q3a
OH


293
N
NEt
Q1c
a bond
Me
a bond
NH
S
a bond
Q3b
OH


294
N
NEt
Q1c
a bond
Me
a bond
NH
S
a bond
Q3c
OH


295
N
NEt
Q1c
a bond
Me
a bond
NH
O
NH
Q3a
OH


296
N
NEt
Q1c
a bond
Me
a bond
NH
O
NH
Q3b
OH


297
N
NEt
Q1c
a bond
Me
a bond
NH
O
NH
Q3c
OH


298
N
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3a
OH


299
N
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3b
OH


300
N
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3c
OH


301
N
NEt
Q1c
a bond
H
a bond
NH
S
NH
Q3a
OH


302
N
NEt
Q1c
a bond
H
a bond
NH
S
NH
Q3b
OH


303
N
NEt
Q1c
a bond
H
a bond
NH
S
NH
Q3c
OH


304
N
NEt
Q1c
a bond
H
a bond
NH
S
a bond
Q3a
OH


305
N
NEt
Q1c
a bond
H
a bond
NH
S
a bond
Q3b
OH


306
N
NEt
Q1c
a bond
H
a bond
NH
S
a bond
Q3c
OH


307
N
NEt
Q1c
a bond
H
a bond
NH
O
NH
Q3a
OH


308
N
NEt
Q1c
a bond
H
a bond
NH
O
NH
Q3b
OH


309
N
NEt
Q1c
a bond
H
a bond
NH
O
NH
Q3c
OH


310
N
NEt
Q1c
a bond
H
a bond
NH
O
a bond
Q3a
OH


311
N
NEt
Q1c
a bond
H
a bond
NH
O
a bond
Q3b
OH


312
N
NEt
Q1c
a bond
H
a bond
NH
O
a bond
Q3c
OH


313
N
NEt
Q1d
a bond
Me
a bond
NH
S
NH
Q3a
OH


314
N
NEt
Q1d
a bond
Me
a bond
NH
S
NH
Q3b
OH


315
N
NEt
Q1d
a bond
Me
a bond
NH
S
NH
Q3c
OH


316
N
NEt
Q1d
a bond
Me
a bond
NH
S
a bond
Q3a
OH


317
N
NEt
Q1d
a bond
Me
a bond
NH
S
a bond
Q3b
OH


318
N
NEt
Q1d
a bond
Me
a bond
NH
S
a bond
Q3c
OH


319
N
NEt
Q1d
a bond
Me
a bond
NH
O
NH
Q3a
OH


320
N
NEt
Q1d
a bond
Me
a bond
NH
O
NH
Q3b
OH


321
N
NEt
Q1d
a bond
Me
a bond
NH
O
NH
Q3c
OH


322
N
NEt
Q1d
a bond
Me
a bond
NH
O
a bond
Q3a
OH


323
N
NEt
Q1d
a bond
Me
a bond
NH
O
a bond
Q3b
OH


324
N
NEt
Q1d
a bond
Me
a bond
NH
O
a bond
Q3c
OH


325
N
NEt
Q1d
a bond
H
a bond
NH
S
NH
Q3a
OH


326
N
NEt
Q1d
a bond
H
a bond
NH
S
NH
Q3b
OH


327
N
NEt
Q1d
a bond
H
a bond
NH
S
NH
Q3c
OH


328
N
NEt
Q1d
a bond
H
a bond
NH
S
a bond
Q3a
OH


329
N
NEt
Q1d
a bond
H
a bond
NH
S
a bond
Q3b
OH


330
N
NEt
Q1d
a bond
H
a bond
NH
S
a bond
Q3c
OH


331
N
NEt
Q1d
a bond
H
a bond
NH
O
NH
Q3a
OH


332
N
NEt
Q1d
a bond
H
a bond
NH
O
NH
Q3b
OH


333
N
NEt
Q1d
a bond
H
a bond
NH
O
NH
Q3c
OH


334
N
NEt
Q1d
a bond
H
a bond
NH
O
a bond
Q3a
OH


335
N
NEt
Q1d
a bond
H
a bond
NH
O
a bond
Q3b
OH


336
N
NEt
Q1d
a bond
H
a bond
NH
O
a bond
Q3c
OH


337
N
NEt
Q1e
a bond
Me
a bond
NH
S
NH
Q3a
OH


338
N
NEt
Q1e
a bond
Me
a bond
NH
S
NH
Q3b
OH


339
N
NEt
Q1e
a bond
Me
a bond
NH
S
NH
Q3c
OH


340
N
NEt
Q1e
a bond
Me
a bond
NH
S
a bond
Q3a
OH


341
N
NEt
Q1e
a bond
Me
a bond
NH
S
a bond
Q3b
OH


342
N
NEt
Q1e
a bond
Me
a bond
NH
S
a bond
Q3c
OH


343
N
NEt
Q1e
a bond
Me
a bond
NH
O
NH
Q3a
OH


344
N
NEt
Q1e
a bond
Me
a bond
NH
O
NH
Q3b
OH


345
N
NEt
Q1e
a bond
Me
a bond
NH
O
NH
Q3c
OH


346
N
NEt
Q1e
a bond
Me
a bond
NH
O
a bond
Q3a
OH


347
N
NEt
Q1e
a bond
Me
a bond
NH
O
a bond
Q3b
OH


348
N
NEt
Q1e
a bond
Me
a bond
NH
O
a bond
Q3c
OH


349
N
NEt
Q1e
a bond
H
a bond
NH
S
NH
Q3a
OH


350
N
NEt
Q1e
a bond
H
a bond
NH
S
NH
Q3b
OH


351
N
NEt
Q1e
a bond
H
a bond
NH
S
NH
Q3c
OH


352
N
NEt
Q1e
a bond
H
a bond
NH
S
a bond
Q3a
OH


353
N
NEt
Q1e
a bond
H
a bond
NH
S
a bond
Q3b
OH


354
N
NEt
Q1e
a bond
H
a bond
NH
S
a bond
Q3c
OH


355
N
NEt
Q1e
a bond
H
a bond
NH
O
NH
Q3a
OH


356
N
NEt
Q1e
a bond
H
a bond
NH
O
NH
Q3b
OH


357
N
NEt
Q1e
a bond
H
a bond
NH
O
NH
Q3c
OH


358
N
NEt
Q1e
a bond
H
a bond
NH
O
a bond
Q3a
OH


359
N
NEt
Q1e
a bond
H
a bond
NH
O
a bond
Q3b
OH


360
N
NEt
Q1e
a bond
H
a bond
NH
O
a bond
Q3c
OH


361
N
NEt
Q1f
a bond
Me
a bond
NH
S
NH
Q3a
OH


362
N
NEt
Q1f
a bond
Me
a bond
NH
S
NH
Q3b
OH


363
N
NEt
Q1f
a bond
Me
a bond
NH
S
NH
Q3c
OH


364
N
NEt
Q1f
a bond
Me
a bond
NH
S
a bond
Q3a
OH


365
N
NEt
Q1f
a bond
Me
a bond
NH
S
a bond
Q3b
OH


366
N
NEt
Q1f
a bond
Me
a bond
NH
S
a bond
Q3c
OH


367
N
NEt
Q1f
a bond
Me
a bond
NH
O
NH
Q3a
OH


368
N
NEt
Q1f
a bond
Me
a bond
NH
O
NH
Q3b
OH


369
N
NEt
Q1f
a bond
Me
a bond
NH
O
NH
Q3c
OH


370
N
NEt
Q1f
a bond
Me
a bond
NH
O
a bond
Q3a
OH


371
N
NEt
Q1f
a bond
Me
a bond
NH
O
a bond
Q3b
OH


372
N
NEt
Q1f
a bond
Me
a bond
NH
O
a bond
Q3c
OH


373
N
NEt
Q1f
a bond
H
a bond
NH
S
NH
Q3a
OH


374
N
NEt
Q1f
a bond
H
a bond
NH
S
NH
Q3b
OH


375
N
NEt
Q1f
a bond
H
a bond
NH
S
NH
Q3c
OH


376
N
NEt
Q1f
a bond
H
a bond
NH
S
a bond
Q3a
OH


377
N
NEt
Q1f
a bond
H
a bond
NH
S
a bond
Q3b
OH


378
N
NEt
Q1f
a bond
H
a bond
NH
S
a bond
Q3c
OH


379
N
NEt
Q1f
a bond
H
a bond
NH
O
NH
Q3a
OH


380
N
NEt
Q1f
a bond
H
a bond
NH
O
NH
Q3b
OH


381
N
NEt
Q1f
a bond
H
a bond
NH
O
NH
Q3c
OH


382
N
NEt
Q1f
a bond
H
a bond
NH
O
a bond
Q3a
OH


383
N
NEt
Q1f
a bond
H
a bond
NH
O
a bond
Q3b
OH


384
N
NEt
Q1f
a bond
H
a bond
NH
O
a bond
Q3c
OH


385
N
NEt
Q1g
a bond
Me
a bond
NH
S
NH
Q3a
OH


386
N
NEt
Q1g
a bond
Me
a bond
NH
S
NH
Q3b
OH


387
N
NEt
Q1g
a bond
Me
a bond
NH
S
NH
Q3c
OH


388
N
NEt
Q1g
a bond
Me
a bond
NH
S
a bond
Q3a
OH


389
N
NEt
Q1g
a bond
Me
a bond
NH
S
a bond
Q3b
OH


390
N
NEt
Q1g
a bond
Me
a bond
NH
S
a bond
Q3c
OH


391
N
NEt
Q1g
a bond
Me
a bond
NH
O
NH
Q3a
OH


392
N
NEt
Q1g
a bond
Me
a bond
NH
O
NH
Q3b
OH


393
N
NEt
Q1g
a bond
Me
a bond
NH
O
NH
Q3c
OH


394
N
NEt
Q1g
a bond
Me
a bond
NH
O
a bond
Q3a
OH


395
N
NEt
Q1g
a bond
Me
a bond
NH
O
a bond
Q3b
OH


396
N
NEt
Q1g
a bond
Me
a bond
NH
O
a bond
Q3c
OH


397
N
NEt
Q1g
a bond
H
a bond
NH
S
NH
Q3a
OH


398
N
NEt
Q1g
a bond
H
a bond
NH
S
NH
Q3b
OH


399
N
NEt
Q1g
a bond
H
a bond
NH
S
NH
Q3c
OH


400
N
NEt
Q1g
a bond
H
a bond
NH
S
a bond
Q3a
OH


401
N
NEt
Q1g
a bond
H
a bond
NH
S
a bond
Q3b
OH


402
N
NEt
Q1g
a bond
H
a bond
NH
S
a bond
Q3c
OH


403
N
NEt
Q1g
a bond
H
a bond
NH
O
NH
Q3a
OH


404
N
NEt
Q1g
a bond
H
a bond
NH
O
NH
Q3b
OH


405
N
NEt
Q1g
a bond
H
a bond
NH
O
NH
Q3c
OH


406
N
NEt
Q1g
a bond
H
a bond
NH
O
a bond
Q3a
OH


407
N
NEt
Q1g
a bond
H
a bond
NH
O
a bond
Q3b
OH


408
N
NEt
Q1g
a bond
H
a bond
NH
O
a bond
Q3c
OH


409
N
NEt
Q1h
a bond
Me
a bond
NH
S
NH
Q3a
OH


410
N
NEt
Q1h
a bond
Me
a bond
NH
S
NH
Q3b
OH


411
N
NEt
Q1h
a bond
Me
a bond
NH
S
NH
Q3c
OH


412
N
NEt
Q1h
a bond
Me
a bond
NH
S
a bond
Q3a
OH


413
N
NEt
Q1h
a bond
Me
a bond
NH
S
a bond
Q3b
OH


414
N
NEt
Q1h
a bond
Me
a bond
NH
S
a bond
Q3c
OH


415
N
NEt
Q1h
a bond
Me
a bond
NH
O
NH
Q3a
OH


416
N
NEt
Q1h
a bond
Me
a bond
NH
O
NH
Q3b
OH


417
N
NEt
Q1h
a bond
Me
a bond
NH
O
NH
Q3c
OH


418
N
NEt
Q1h
a bond
Me
a bond
NH
O
a bond
Q3a
OH


419
N
NEt
Q1h
a bond
Me
a bond
NH
O
a bond
Q3b
OH


420
N
NEt
Q1h
a bond
Me
a bond
NH
O
a bond
Q3c
OH


421
N
NEt
Q1h
a bond
H
a bond
NH
S
NH
Q3a
OH


422
N
NEt
Q1h
a bond
H
a bond
NH
S
NH
Q3b
OH


423
N
NEt
Q1h
a bond
H
a bond
NH
S
NH
Q3c
OH


424
N
NEt
Q1h
a bond
H
a bond
NH
S
a bond
Q3a
OH


425
N
NEt
Q1h
a bond
H
a bond
NH
S
a bond
Q3b
OH


426
N
NEt
Q1h
a bond
H
a bond
NH
S
a bond
Q3c
OH


427
N
NEt
Q1h
a bond
H
a bond
NH
O
NH
Q3a
OH


428
N
NEt
Q1h
a bond
H
a bond
NH
O
NH
Q3b
OH


429
N
NEt
Q1h
a bond
H
a bond
NH
O
NH
Q3c
OH


430
N
NEt
Q1h
a bond
H
a bond
NH
O
a bond
Q3a
OH


431
N
NEt
Q1h
a bond
H
a bond
NH
O
a bond
Q3b
OH


432
N
NEt
Q1h
a bond
H
a bond
NH
O
a bond
Q3c
OH


433
N
NEt
Q1i
a bond
Me
a bond
NH
S
NH
Q3a
OH


434
N
NEt
Q1i
a bond
Me
a bond
NH
S
NH
Q3b
OH


435
N
NEt
Q1i
a bond
Me
a bond
NH
S
NH
Q3c
OH


436
N
NEt
Q1i
a bond
Me
a bond
NH
S
a bond
Q3a
OH


437
N
NEt
Q1i
a bond
Me
a bond
NH
S
a bond
Q3b
OH


438
N
NEt
Q1i
a bond
Me
a bond
NH
S
a bond
Q3c
OH


439
N
NEt
Q1i
a bond
Me
a bond
NH
O
NH
Q3a
OH


440
N
NEt
Q1i
a bond
Me
a bond
NH
O
NH
Q3b
OH


441
N
NEt
Q1i
a bond
Me
a bond
NH
O
NH
Q3c
OH


442
N
NEt
Q1i
a bond
Me
a bond
NH
O
a bond
Q3a
OH


443
N
NEt
Q1i
a bond
Me
a bond
NH
O
a bond
Q3b
OH


444
N
NEt
Q1i
a bond
Me
a bond
NH
O
a bond
Q3c
OH


445
N
NEt
Q1i
a bond
H
a bond
NH
S
NH
Q3a
OH


446
N
NEt
Q1i
a bond
H
a bond
NH
S
NH
Q3b
OH


447
N
NEt
Q1i
a bond
H
a bond
NH
S
NH
Q3c
OH


448
N
NEt
Q1i
a bond
H
a bond
NH
S
a bond
Q3a
OH


449
N
NEt
Q1i
a bond
H
a bond
NH
S
a bond
Q3b
OH


450
N
NEt
Q1i
a bond
H
a bond
NH
S
a bond
Q3c
OH


451
N
NEt
Q1i
a bond
H
a bond
NH
O
NH
Q3a
OH


452
N
NEt
Q1i
a bond
H
a bond
NH
O
NH
Q3b
OH


453
N
NEt
Q1i
a bond
H
a bond
NH
O
NH
Q3c
OH


454
N
NEt
Q1i
a bond
H
a bond
NH
O
a bond
Q3a
OH


455
N
NEt
Q1i
a bond
H
a bond
NH
O
a bond
Q3b
OH


456
N
NEt
Q1i
a bond
H
a bond
NH
O
a bond
Q3c
OH


457
N
NEt
Q1j
a bond
Me
a bond
NH
S
NH
Q3a
OH


458
N
NEt
Q1j
a bond
Me
a bond
NH
S
NH
Q3b
OH


459
N
NEt
Q1j
a bond
Me
a bond
NH
S
NH
Q3c
OH


460
N
NEt
Q1j
a bond
Me
a bond
NH
S
a bond
Q3a
OH


461
N
NEt
Q1j
a bond
Me
a bond
NH
S
a bond
Q3b
OH


462
N
NEt
Q1j
a bond
Me
a bond
NH
S
a bond
Q3c
OH


463
N
NEt
Q1j
a bond
Me
a bond
NH
O
NH
Q3a
OH


464
N
NEt
Q1j
a bond
Me
a bond
NH
O
NH
Q3b
OH


465
N
NEt
Q1j
a bond
Me
a bond
NH
O
NH
Q3c
OH


466
N
NEt
Q1j
a bond
Me
a bond
NH
O
a bond
Q3a
OH


467
N
NEt
Q1j
a bond
Me
a bond
NH
O
a bond
Q3b
OH


468
N
NEt
Q1j
a bond
Me
a bond
NH
O
a bond
Q3c
OH


469
N
NEt
Q1j
a bond
H
a bond
NH
S
NH
Q3a
OH


470
N
NEt
Q1j
a bond
H
a bond
NH
S
NH
Q3b
OH


471
N
NEt
Q1j
a bond
H
a bond
NH
S
NH
Q3c
OH


472
N
NEt
Q1j
a bond
H
a bond
NH
S
a bond
Q3a
OH


473
N
NEt
Q1j
a bond
H
a bond
NH
S
a bond
Q3b
OH


474
N
NEt
Q1j
a bond
H
a bond
NH
S
a bond
Q3c
OH


475
N
NEt
Q1j
a bond
H
a bond
NH
O
NH
Q3a
OH


476
N
NEt
Q1j
a bond
H
a bond
NH
O
NH
Q3b
OH


477
N
NEt
Q1j
a bond
H
a bond
NH
O
NH
Q3c
OH


478
N
NEt
Q1j
a bond
H
a bond
NH
O
a bond
Q3a
OH


479
N
NEt
Q1j
a bond
H
a bond
NH
O
a bond
Q3b
OH


480
N
NEt
Q1j
a bond
H
a bond
NH
O
a bond
Q3c
OH


481
N
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3a
OH


482
N
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3b
OH


483
N
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3c
OH


484
N
S
Q1a
a bond
Me
a bond
NH
S
a bond
Q3a
OH


485
N
S
Q1a
a bond
Me
a bond
NH
S
a bond
Q3b
OH


486
N
S
Q1a
a bond
Me
a bond
NH
S
a bond
Q3c
OH


487
N
S
Q1a
a bond
Me
a bond
NH
O
NH
Q3a
OH


488
N
S
Q1a
a bond
Me
a bond
NH
O
NH
Q3b
OH


489
N
S
Q1a
a bond
Me
a bond
NH
O
NH
Q3c
OH


490
N
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3a
OH


491
N
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3b
OH


492
N
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3c
OH


493
N
S
Q1a
a bond
H
a bond
NH
S
NH
Q3a
OH


494
N
S
Q1a
a bond
H
a bond
NH
S
NH
Q3b
OH


495
N
S
Q1a
a bond
H
a bond
NH
S
NH
Q3c
OH


496
N
S
Q1a
a bond
H
a bond
NH
S
a bond
Q3a
OH


497
N
S
Q1a
a bond
H
a bond
NH
S
a bond
Q3b
OH


498
N
S
Q1a
a bond
H
a bond
NH
S
a bond
Q3c
OH


499
N
S
Q1a
a bond
H
a bond
NH
O
NH
Q3a
OH


500
N
S
Q1a
a bond
H
a bond
NH
O
NH
Q3b
OH


501
N
S
Q1a
a bond
H
a bond
NH
O
NH
Q3c
OH


502
N
S
Q1a
a bond
H
a bond
NH
O
a bond
Q3a
OH


503
N
S
Q1a
a bond
H
a bond
NH
O
a bond
Q3b
OH


504
N
S
Q1a
a bond
H
a bond
NH
O
a bond
Q3c
OH


505
N
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3a
OH


506
N
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3b
OH


507
N
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3c
OH


508
N
S
Q1b
a bond
Me
a bond
NH
S
a bond
Q3a
OH


509
N
S
Q1b
a bond
Me
a bond
NH
S
a bond
Q3b
OH


510
N
S
Q1b
a bond
Me
a bond
NH
S
a bond
Q3c
OH


511
N
S
Q1b
a bond
Me
a bond
NH
O
NH
Q3a
OH


512
N
S
Q1b
a bond
Me
a bond
NH
O
NH
Q3b
OH


513
N
S
Q1b
a bond
Me
a bond
NH
O
NH
Q3c
OH


514
N
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3a
OH


515
N
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3b
OH


516
N
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3c
OH


517
N
S
Q1b
a bond
H
a bond
NH
S
NH
Q3a
OH


518
N
S
Q1b
a bond
H
a bond
NH
S
NH
Q3b
OH


519
N
S
Q1b
a bond
H
a bond
NH
S
NH
Q3c
OH


520
N
S
Q1b
a bond
H
a bond
NH
S
a bond
Q3a
OH


521
N
S
Q1b
a bond
H
a bond
NH
S
a bond
Q3b
OH


522
N
S
Q1b
a bond
H
a bond
NH
S
a bond
Q3c
OH


523
N
S
Q1b
a bond
H
a bond
NH
O
NH
Q3a
OH


524
N
S
Q1b
a bond
H
a bond
NH
O
NH
Q3b
OH


525
N
S
Q1b
a bond
H
a bond
NH
O
NH
Q3c
OH


526
N
S
Q1b
a bond
H
a bond
NH
O
a bond
Q3a
OH


527
N
S
Q1b
a bond
H
a bond
NH
O
a bond
Q3b
OH


528
N
S
Q1b
a bond
H
a bond
NH
O
a bond
Q3c
OH


529
N
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3a
OH


530
N
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3b
OH


531
N
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3c
OH


532
N
S
Q1c
a bond
Me
a bond
NH
S
a bond
Q3a
OH


533
N
S
Q1c
a bond
Me
a bond
NH
S
a bond
Q3b
OH


534
N
S
Q1c
a bond
Me
a bond
NH
S
a bond
Q3c
OH


535
N
S
Q1c
a bond
Me
a bond
NH
O
NH
Q3a
OH


536
N
S
Q1c
a bond
Me
a bond
NH
O
NH
Q3b
OH


537
N
S
Q1c
a bond
Me
a bond
NH
O
NH
Q3c
OH


538
N
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3a
OH


539
N
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3b
OH


540
N
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3c
OH


541
N
S
Q1c
a bond
H
a bond
NH
S
NH
Q3a
OH


542
N
S
Q1c
a bond
H
a bond
NH
S
NH
Q3b
OH


543
N
S
Q1c
a bond
H
a bond
NH
S
NH
Q3c
OH


544
N
S
Q1c
a bond
H
a bond
NH
S
a bond
Q3a
OH


545
N
S
Q1c
a bond
H
a bond
NH
S
a bond
Q3b
OH


546
N
S
Q1c
a bond
H
a bond
NH
S
a bond
Q3c
OH


547
N
S
Q1c
a bond
H
a bond
NH
O
NH
Q3a
OH


548
N
S
Q1c
a bond
H
a bond
NH
O
NH
Q3b
OH


549
N
S
Q1c
a bond
H
a bond
NH
O
NH
Q3c
OH


550
N
S
Q1c
a bond
H
a bond
NH
O
a bond
Q3a
OH


551
N
S
Q1c
a bond
H
a bond
NH
O
a bond
Q3b
OH


552
N
S
Q1c
a bond
H
a bond
NH
O
a bond
Q3c
OH


553
N
S
Q1d
a bond
Me
a bond
NH
S
NH
Q3a
OH


554
N
S
Q1d
a bond
Me
a bond
NH
S
NH
Q3b
OH


555
N
S
Q1d
a bond
Me
a bond
NH
S
NH
Q3c
OH


556
N
S
Q1d
a bond
Me
a bond
NH
S
a bond
Q3a
OH


557
N
S
Q1d
a bond
Me
a bond
NH
S
a bond
Q3b
OH


558
N
S
Q1d
a bond
Me
a bond
NH
S
a bond
Q3c
OH


559
N
S
Q1d
a bond
Me
a bond
NH
O
NH
Q3a
OH


560
N
S
Q1d
a bond
Me
a bond
NH
O
NH
Q3b
OH


561
N
S
Q1d
a bond
Me
a bond
NH
O
NH
Q3c
OH


562
N
S
Q1d
a bond
Me
a bond
NH
O
a bond
Q3a
OH


563
N
S
Q1d
a bond
Me
a bond
NH
O
a bond
Q3b
OH


564
N
S
Q1d
a bond
Me
a bond
NH
O
a bond
Q3c
OH


565
N
S
Q1d
a bond
H
a bond
NH
S
NH
Q3a
OH


566
N
S
Q1d
a bond
H
a bond
NH
S
NH
Q3b
OH


567
N
S
Q1d
a bond
H
a bond
NH
S
NH
Q3c
OH


568
N
S
Q1d
a bond
H
a bond
NH
S
a bond
Q3a
OH


569
N
S
Q1d
a bond
H
a bond
NH
S
a bond
Q3b
OH


570
N
S
Q1d
a bond
H
a bond
NH
S
a bond
Q3c
OH


571
N
S
Q1d
a bond
H
a bond
NH
O
NH
Q3a
OH


572
N
S
Q1d
a bond
H
a bond
NH
O
NH
Q3b
OH


573
N
S
Q1d
a bond
H
a bond
NH
O
NH
Q3c
OH


574
N
S
Q1d
a bond
H
a bond
NH
O
a bond
Q3a
OH


575
N
S
Q1d
a bond
H
a bond
NH
O
a bond
Q3b
OH


576
N
S
Q1d
a bond
H
a bond
NH
O
a bond
Q3c
OH


577
N
S
Q1e
a bond
Me
a bond
NH
S
NH
Q3a
OH


578
N
S
Q1e
a bond
Me
a bond
NH
S
NH
Q3b
OH


579
N
S
Q1e
a bond
Me
a bond
NH
S
NH
Q3c
OH


580
N
S
Q1e
a bond
Me
a bond
NH
S
a bond
Q3a
OH


581
N
S
Q1e
a bond
Me
a bond
NH
S
a bond
Q3b
OH


582
N
S
Q1e
a bond
Me
a bond
NH
S
a bond
Q3c
OH


583
N
S
Q1e
a bond
Me
a bond
NH
O
NH
Q3a
OH


584
N
S
Q1e
a bond
Me
a bond
NH
O
NH
Q3b
OH


585
N
S
Q1e
a bond
Me
a bond
NH
O
NH
Q3c
OH


586
N
S
Q1e
a bond
Me
a bond
NH
O
a bond
Q3a
OH


587
N
S
Q1e
a bond
Me
a bond
NH
O
a bond
Q3b
OH


588
N
S
Q1e
a bond
Me
a bond
NH
O
a bond
Q3c
OH


589
N
S
Q1e
a bond
H
a bond
NH
S
NH
Q3a
OH


590
N
S
Q1e
a bond
H
a bond
NH
S
NH
Q3b
OH


591
N
S
Q1e
a bond
H
a bond
NH
S
NH
Q3c
OH


592
N
S
Q1e
a bond
H
a bond
NH
S
a bond
Q3a
OH


593
N
S
Q1e
a bond
H
a bond
NH
S
a bond
Q3b
OH


594
N
S
Q1e
a bond
H
a bond
NH
S
a bond
Q3c
OH


595
N
S
Q1e
a bond
H
a bond
NH
O
NH
Q3a
OH


596
N
S
Q1e
a bond
H
a bond
NH
O
NH
Q3b
OH


597
N
S
Q1e
a bond
H
a bond
NH
O
NH
Q3c
OH


598
N
S
Q1e
a bond
H
a bond
NH
O
a bond
Q3a
OH


599
N
S
Q1e
a bond
H
a bond
NH
O
a bond
Q3b
OH


600
N
S
Q1e
a bond
H
a bond
NH
O
a bond
Q3c
OH


601
N
S
Q1f
a bond
Me
a bond
NH
S
NH
Q3a
OH


602
N
S
Q1f
a bond
Me
a bond
NH
S
NH
Q3b
OH


603
N
S
Q1f
a bond
Me
a bond
NH
S
NH
Q3c
OH


604
N
S
Q1f
a bond
Me
a bond
NH
S
a bond
Q3a
OH


605
N
S
Q1f
a bond
Me
a bond
NH
S
a bond
Q3b
OH


606
N
S
Q1f
a bond
Me
a bond
NH
S
a bond
Q3c
OH


607
N
S
Q1f
a bond
Me
a bond
NH
O
NH
Q3a
OH


608
N
S
Q1f
a bond
Me
a bond
NH
O
NH
Q3b
OH


609
N
S
Q1f
a bond
Me
a bond
NH
O
NH
Q3c
OH


610
N
S
Q1f
a bond
Me
a bond
NH
O
a bond
Q3a
OH


611
N
S
Q1f
a bond
Me
a bond
NH
O
a bond
Q3b
OH


612
N
S
Q1f
a bond
Me
a bond
NH
O
a bond
Q3c
OH


613
N
S
Q1f
a bond
H
a bond
NH
S
NH
Q3a
OH


614
N
S
Q1f
a bond
H
a bond
NH
S
NH
Q3b
OH


615
N
S
Q1f
a bond
H
a bond
NH
S
NH
Q3c
OH


616
N
S
Q1f
a bond
H
a bond
NH
S
a bond
Q3a
OH


617
N
S
Q1f
a bond
H
a bond
NH
S
a bond
Q3b
OH


618
N
S
Q1f
a bond
H
a bond
NH
S
a bond
Q3c
OH


619
N
S
Q1f
a bond
H
a bond
NH
O
NH
Q3a
OH


620
N
S
Q1f
a bond
H
a bond
NH
O
NH
Q3b
OH


621
N
S
Q1f
a bond
H
a bond
NH
O
NH
Q3c
OH


622
N
S
Q1f
a bond
H
a bond
NH
O
a bond
Q3a
OH


623
N
S
Q1f
a bond
H
a bond
NH
O
a bond
Q3b
OH


624
N
S
Q1f
a bond
H
a bond
NH
O
a bond
Q3c
OH


625
N
S
Q1g
a bond
Me
a bond
NH
S
NH
Q3a
OH


626
N
S
Q1g
a bond
Me
a bond
NH
S
NH
Q3b
OH


627
N
S
Q1g
a bond
Me
a bond
NH
S
NH
Q3c
OH


628
N
S
Q1g
a bond
Me
a bond
NH
S
a bond
Q3a
OH


629
N
S
Q1g
a bond
Me
a bond
NH
S
a bond
Q3b
OH


630
N
S
Q1g
a bond
Me
a bond
NH
S
a bond
Q3c
OH


631
N
S
Q1g
a bond
Me
a bond
NH
O
NH
Q3a
OH


632
N
S
Q1g
a bond
Me
a bond
NH
O
NH
Q3b
OH


633
N
S
Q1g
a bond
Me
a bond
NH
O
NH
Q3c
OH


634
N
S
Q1g
a bond
Me
a bond
NH
O
a bond
Q3a
OH


635
N
S
Q1g
a bond
Me
a bond
NH
O
a bond
Q3b
OH


636
N
S
Q1g
a bond
Me
a bond
NH
O
a bond
Q3c
OH


637
N
S
Q1g
a bond
H
a bond
NH
S
NH
Q3a
OH


638
N
S
Q1g
a bond
H
a bond
NH
S
NH
Q3b
OH


639
N
S
Q1g
a bond
H
a bond
NH
S
NH
Q3c
OH


640
N
S
Q1g
a bond
H
a bond
NH
S
a bond
Q3a
OH


641
N
S
Q1g
a bond
H
a bond
NH
S
a bond
Q3b
OH


642
N
S
Q1g
a bond
H
a bond
NH
S
a bond
Q3c
OH


643
N
S
Q1g
a bond
H
a bond
NH
O
NH
Q3a
OH


644
N
S
Q1g
a bond
H
a bond
NH
O
NH
Q3b
OH


645
N
S
Q1g
a bond
H
a bond
NH
O
NH
Q3c
OH


646
N
S
Q1g
a bond
H
a bond
NH
O
a bond
Q3a
OH


647
N
S
Q1g
a bond
H
a bond
NH
O
a bond
Q3b
OH


648
N
S
Q1g
a bond
H
a bond
NH
O
a bond
Q3c
OH


649
N
S
Q1h
a bond
Me
a bond
NH
S
NH
Q3a
OH


650
N
S
Q1h
a bond
Me
a bond
NH
S
NH
Q3b
OH


651
N
S
Q1h
a bond
Me
a bond
NH
S
NH
Q3c
OH


652
N
S
Q1h
a bond
Me
a bond
NH
S
a bond
Q3a
OH


653
N
S
Q1h
a bond
Me
a bond
NH
S
a bond
Q3b
OH


654
N
S
Q1h
a bond
Me
a bond
NH
S
a bond
Q3c
OH


655
N
S
Q1h
a bond
Me
a bond
NH
O
NH
Q3a
OH


656
N
S
Q1h
a bond
Me
a bond
NH
O
NH
Q3b
OH


657
N
S
Q1h
a bond
Me
a bond
NH
O
NH
Q3c
OH


658
N
S
Q1h
a bond
Me
a bond
NH
O
a bond
Q3a
OH


659
N
S
Q1h
a bond
Me
a bond
NH
O
a bond
Q3b
OH


660
N
S
Q1h
a bond
Me
a bond
NH
O
a bond
Q3c
OH


661
N
S
Q1h
a bond
H
a bond
NH
S
NH
Q3a
OH


662
N
S
Q1h
a bond
H
a bond
NH
S
NH
Q3b
OH


663
N
S
Q1h
a bond
H
a bond
NH
S
NH
Q3c
OH


664
N
S
Q1h
a bond
H
a bond
NH
S
a bond
Q3a
OH


665
N
S
Q1h
a bond
H
a bond
NH
S
a bond
Q3b
OH


666
N
S
Q1h
a bond
H
a bond
NH
S
a bond
Q3c
OH


667
N
S
Q1h
a bond
H
a bond
NH
O
NH
Q3a
OH


668
N
S
Q1h
a bond
H
a bond
NH
O
NH
Q3b
OH


669
N
S
Q1h
a bond
H
a bond
NH
O
NH
Q3c
OH


670
N
S
Q1h
a bond
H
a bond
NH
O
a bond
Q3a
OH


671
N
S
Q1h
a bond
H
a bond
NH
O
a bond
Q3b
OH


672
N
S
Q1h
a bond
H
a bond
NH
O
a bond
Q3c
OH


673
N
S
Q1i
a bond
Me
a bond
NH
S
NH
Q3a
OH


674
N
S
Q1i
a bond
Me
a bond
NH
S
NH
Q3b
OH


675
N
S
Q1i
a bond
Me
a bond
NH
S
NH
Q3c
OH


676
N
S
Q1i
a bond
Me
a bond
NH
S
a bond
Q3a
OH


677
N
S
Q1i
a bond
Me
a bond
NH
S
a bond
Q3b
OH


678
N
S
Q1i
a bond
Me
a bond
NH
S
a bond
Q3c
OH


679
N
S
Q1i
a bond
Me
a bond
NH
O
NH
Q3a
OH


680
N
S
Q1i
a bond
Me
a bond
NH
O
NH
Q3b
OH


681
N
S
Q1i
a bond
Me
a bond
NH
O
NH
Q3c
OH


682
N
S
Q1i
a bond
Me
a bond
NH
O
a bond
Q3a
OH


683
N
S
Q1i
a bond
Me
a bond
NH
O
a bond
Q3b
OH


684
N
S
Q1i
a bond
Me
a bond
NH
O
a bond
Q3c
OH


685
N
S
Q1i
a bond
H
a bond
NH
S
NH
Q3a
OH


686
N
S
Q1i
a bond
H
a bond
NH
S
NH
Q3b
OH


687
N
S
Q1i
a bond
H
a bond
NH
S
NH
Q3c
OH


688
N
S
Q1i
a bond
H
a bond
NH
S
a bond
Q3a
OH


689
N
S
Q1i
a bond
H
a bond
NH
S
a bond
Q3b
OH


690
N
S
Q1i
a bond
H
a bond
NH
S
a bond
Q3c
OH


691
N
S
Q1i
a bond
H
a bond
NH
O
NH
Q3a
OH


692
N
S
Q1i
a bond
H
a bond
NH
O
NH
Q3b
OH


693
N
S
Q1i
a bond
H
a bond
NH
O
NH
Q3c
OH


694
N
S
Q1i
a bond
H
a bond
NH
O
a bond
Q3a
OH


695
N
S
Q1i
a bond
H
a bond
NH
O
a bond
Q3b
OH


696
N
S
Q1i
a bond
H
a bond
NH
O
a bond
Q3c
OH


697
N
S
Q1j
a bond
Me
a bond
NH
S
NH
Q3a
OH


698
N
S
Q1j
a bond
Me
a bond
NH
S
NH
Q3b
OH


699
N
S
Q1j
a bond
Me
a bond
NH
S
NH
Q3c
OH


700
N
S
Q1j
a bond
Me
a bond
NH
S
a bond
Q3a
OH


701
N
S
Q1j
a bond
Me
a bond
NH
S
a bond
Q3b
OH


702
N
S
Q1j
a bond
Me
a bond
NH
S
a bond
Q3c
OH


703
N
S
Q1j
a bond
Me
a bond
NH
O
NH
Q3a
OH


704
N
S
Q1j
a bond
Me
a bond
NH
O
NH
Q3b
OH


705
N
S
Q1j
a bond
Me
a bond
NH
O
NH
Q3c
OH


706
N
S
Q1j
a bond
Me
a bond
NH
O
a bond
Q3a
OH


707
N
S
Q1j
a bond
Me
a bond
NH
O
a bond
Q3b
OH


708
N
S
Q1j
a bond
Me
a bond
NH
O
a bond
Q3c
OH


709
N
S
Q1j
a bond
H
a bond
NH
S
NH
Q3a
OH


710
N
S
Q1j
a bond
H
a bond
NH
S
NH
Q3b
OH


711
N
S
Q1j
a bond
H
a bond
NH
S
NH
Q3c
OH


712
N
S
Q1j
a bond
H
a bond
NH
S
a bond
Q3a
OH


713
N
S
Q1j
a bond
H
a bond
NH
S
a bond
Q3b
OH


714
N
S
Q1j
a bond
H
a bond
NH
S
a bond
Q3c
OH


715
N
S
Q1j
a bond
H
a bond
NH
O
NH
Q3a
OH


716
N
S
Q1j
a bond
H
a bond
NH
O
NH
Q3b
OH


717
N
S
Q1j
a bond
H
a bond
NH
O
NH
Q3c
OH


718
N
S
Q1j
a bond
H
a bond
NH
O
a bond
Q3a
OH


719
N
S
Q1j
a bond
H
a bond
NH
O
a bond
Q3b
OH


720
N
S
Q1j
a bond
H
a bond
NH
O
a bond
Q3c
OH


721
N
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3a
OH


722
N
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3b
OH


723
N
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3c
OH


724
N
O
Q1a
a bond
Me
a bond
NH
S
a bond
Q3a
OH


725
N
O
Q1a
a bond
Me
a bond
NH
S
a bond
Q3b
OH


726
N
O
Q1a
a bond
Me
a bond
NH
S
a bond
Q3c
OH


727
N
O
Q1a
a bond
Me
a bond
NH
O
NH
Q3a
OH


728
N
O
Q1a
a bond
Me
a bond
NH
O
NH
Q3b
OH


729
N
O
Q1a
a bond
Me
a bond
NH
O
NH
Q3c
OH


730
N
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3a
OH


731
N
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3b
OH


732
N
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3c
OH


733
N
O
Q1a
a bond
H
a bond
NH
S
NH
Q3a
OH


734
N
O
Q1a
a bond
H
a bond
NH
S
NH
Q3b
OH


735
N
O
Q1a
a bond
H
a bond
NH
S
NH
Q3c
OH


736
N
O
Q1a
a bond
H
a bond
NH
S
a bond
Q3a
OH


737
N
O
Q1a
a bond
H
a bond
NH
S
a bond
Q3b
OH


738
N
O
Q1a
a bond
H
a bond
NH
S
a bond
Q3c
OH


739
N
O
Q1a
a bond
H
a bond
NH
O
NH
Q3a
OH


740
N
O
Q1a
a bond
H
a bond
NH
O
NH
Q3b
OH


741
N
O
Q1a
a bond
H
a bond
NH
O
NH
Q3c
OH


742
N
O
Q1a
a bond
H
a bond
NH
O
a bond
Q3a
OH


743
N
O
Q1a
a bond
H
a bond
NH
O
a bond
Q3b
OH


744
N
O
Q1a
a bond
H
a bond
NH
O
a bond
Q3c
OH


745
N
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3a
OH


746
N
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3b
OH


747
N
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3c
OH


748
N
O
Q1b
a bond
Me
a bond
NH
S
a bond
Q3a
OH


749
N
O
Q1b
a bond
Me
a bond
NH
S
a bond
Q3b
OH


750
N
O
Q1b
a bond
Me
a bond
NH
S
a bond
Q3c
OH


751
N
O
Q1b
a bond
Me
a bond
NH
O
NH
Q3a
OH


752
N
O
Q1b
a bond
Me
a bond
NH
O
NH
Q3b
OH


753
N
O
Q1b
a bond
Me
a bond
NH
O
NH
Q3c
OH


754
N
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3a
OH


755
N
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3b
OH


756
N
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3c
OH


757
N
O
Q1b
a bond
H
a bond
NH
S
NH
Q3a
OH


758
N
O
Q1b
a bond
H
a bond
NH
S
NH
Q3b
OH


759
N
O
Q1b
a bond
H
a bond
NH
S
NH
Q3c
OH


760
N
O
Q1b
a bond
H
a bond
NH
S
a bond
Q3a
OH


761
N
O
Q1b
a bond
H
a bond
NH
S
a bond
Q3b
OH


762
N
O
Q1b
a bond
H
a bond
NH
S
a bond
Q3c
OH


763
N
O
Q1b
a bond
H
a bond
NH
O
NH
Q3a
OH


764
N
O
Q1b
a bond
H
a bond
NH
O
NH
Q3b
OH


765
N
O
Q1b
a bond
H
a bond
NH
O
NH
Q3c
OH


766
N
O
Q1b
a bond
H
a bond
NH
O
a bond
Q3a
OH


767
N
O
Q1b
a bond
H
a bond
NH
O
a bond
Q3b
OH


768
N
O
Q1b
a bond
H
a bond
NH
O
a bond
Q3c
OH


769
N
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3a
OH


770
N
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3b
OH


771
N
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3c
OH


772
N
O
Q1c
a bond
Me
a bond
NH
S
a bond
Q3a
OH


773
N
O
Q1c
a bond
Me
a bond
NH
S
a bond
Q3b
OH


774
N
O
Q1c
a bond
Me
a bond
NH
S
a bond
Q3c
OH


775
N
O
Q1c
a bond
Me
a bond
NH
O
NH
Q3a
OH


776
N
O
Q1c
a bond
Me
a bond
NH
O
NH
Q3b
OH


777
N
O
Q1c
a bond
Me
a bond
NH
O
NH
Q3c
OH


778
N
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3a
OH


779
N
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3b
OH


780
N
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3c
OH


781
N
O
Q1c
a bond
H
a bond
NH
S
NH
Q3a
OH


782
N
O
Q1c
a bond
H
a bond
NH
S
NH
Q3b
OH


783
N
O
Q1c
a bond
H
a bond
NH
S
NH
Q3c
OH


784
N
O
Q1c
a bond
H
a bond
NH
S
a bond
Q3a
OH


785
N
O
Q1c
a bond
H
a bond
NH
S
a bond
Q3b
OH


786
N
O
Q1c
a bond
H
a bond
NH
S
a bond
Q3c
OH


787
N
O
Q1c
a bond
H
a bond
NH
O
NH
Q3a
OH


788
N
O
Q1c
a bond
H
a bond
NH
O
NH
Q3b
OH


789
N
O
Q1c
a bond
H
a bond
NH
O
NH
Q3c
OH


790
N
O
Q1c
a bond
H
a bond
NH
O
a bond
Q3a
OH


791
N
O
Q1c
a bond
H
a bond
NH
O
a bond
Q3b
OH


792
N
O
Q1c
a bond
H
a bond
NH
O
a bond
Q3c
OH


793
N
O
Q1d
a bond
Me
a bond
NH
S
NH
Q3a
OH


794
N
O
Q1d
a bond
Me
a bond
NH
S
NH
Q3b
OH


795
N
O
Q1d
a bond
Me
a bond
NH
S
NH
Q3c
OH


796
N
O
Q1d
a bond
Me
a bond
NH
S
a bond
Q3a
OH


797
N
O
Q1d
a bond
Me
a bond
NH
S
a bond
Q3b
OH


798
N
O
Q1d
a bond
Me
a bond
NH
S
a bond
Q3c
OH


799
N
O
Q1d
a bond
Me
a bond
NH
O
NH
Q3a
OH


800
N
O
Q1d
a bond
Me
a bond
NH
O
NH
Q3b
OH


801
N
O
Q1d
a bond
Me
a bond
NH
O
NH
Q3c
OH


802
N
O
Q1d
a bond
Me
a bond
NH
O
a bond
Q3a
OH


803
N
O
Q1d
a bond
Me
a bond
NH
O
a bond
Q3b
OH


804
N
O
Q1d
a bond
Me
a bond
NH
O
a bond
Q3c
OH


805
N
O
Q1d
a bond
H
a bond
NH
S
NH
Q3a
OH


806
N
O
Q1d
a bond
H
a bond
NH
S
NH
Q3b
OH


807
N
O
Q1d
a bond
H
a bond
NH
S
NH
Q3c
OH


808
N
O
Q1d
a bond
H
a bond
NH
S
a bond
Q3a
OH


809
N
O
Q1d
a bond
H
a bond
NH
S
a bond
Q3b
OH


810
N
O
Q1d
a bond
H
a bond
NH
S
a bond
Q3c
OH


811
N
O
Q1d
a bond
H
a bond
NH
O
NH
Q3a
OH


812
N
O
Q1d
a bond
H
a bond
NH
O
NH
Q3b
OH


813
N
O
Q1d
a bond
H
a bond
NH
O
NH
Q3c
OH


814
N
O
Q1d
a bond
H
a bond
NH
O
a bond
Q3a
OH


815
N
O
Q1d
a bond
H
a bond
NH
O
a bond
Q3b
OH


816
N
O
Q1d
a bond
H
a bond
NH
O
a bond
Q3c
OH


817
N
O
Q1e
a bond
Me
a bond
NH
S
NH
Q3a
OH


818
N
O
Q1e
a bond
Me
a bond
NH
S
NH
Q3b
OH


819
N
O
Q1e
a bond
Me
a bond
NH
S
NH
Q3c
OH


820
N
O
Q1e
a bond
Me
a bond
NH
S
a bond
Q3a
OH


821
N
O
Q1e
a bond
Me
a bond
NH
S
a bond
Q3b
OH


822
N
O
Q1e
a bond
Me
a bond
NH
S
a bond
Q3c
OH


823
N
O
Q1e
a bond
Me
a bond
NH
O
NH
Q3a
OH


824
N
O
Q1e
a bond
Me
a bond
NH
O
NH
Q3b
OH


825
N
O
Q1e
a bond
Me
a bond
NH
O
NH
Q3c
OH


826
N
O
Q1e
a bond
Me
a bond
NH
O
a bond
Q3a
OH


827
N
O
Q1e
a bond
Me
a bond
NH
O
a bond
Q3b
OH


828
N
O
Q1e
a bond
Me
a bond
NH
O
a bond
Q3c
OH


829
N
O
Q1e
a bond
H
a bond
NH
S
NH
Q3a
OH


830
N
O
Q1e
a bond
H
a bond
NH
S
NH
Q3b
OH


831
N
O
Q1e
a bond
H
a bond
NH
S
NH
Q3c
OH


832
N
O
Q1e
a bond
H
a bond
NH
S
a bond
Q3a
OH


833
N
O
Q1e
a bond
H
a bond
NH
S
a bond
Q3b
OH


834
N
O
Q1e
a bond
H
a bond
NH
S
a bond
Q3c
OH


835
N
O
Q1e
a bond
H
a bond
NH
O
NH
Q3a
OH


836
N
O
Q1e
a bond
H
a bond
NH
O
NH
Q3b
OH


837
N
O
Q1e
a bond
H
a bond
NH
O
NH
Q3c
OH


838
N
O
Q1e
a bond
H
a bond
NH
O
a bond
Q3a
OH


839
N
O
Q1e
a bond
H
a bond
NH
O
a bond
Q3b
OH


840
N
O
Q1e
a bond
H
a bond
NH
O
a bond
Q3c
OH


841
N
O
Q1f
a bond
Me
a bond
NH
S
NH
Q3a
OH


842
N
O
Q1f
a bond
Me
a bond
NH
S
NH
Q3b
OH


843
N
O
Q1f
a bond
Me
a bond
NH
S
NH
Q3c
OH


844
N
O
Q1f
a bond
Me
a bond
NH
S
a bond
Q3a
OH


845
N
O
Q1f
a bond
Me
a bond
NH
S
a bond
Q3b
OH


846
N
O
Q1f
a bond
Me
a bond
NH
S
a bond
Q3c
OH


847
N
O
Q1f
a bond
Me
a bond
NH
O
NH
Q3a
OH


848
N
O
Q1f
a bond
Me
a bond
NH
O
NH
Q3b
OH


849
N
O
Q1f
a bond
Me
a bond
NH
O
NH
Q3c
OH


850
N
O
Q1f
a bond
Me
a bond
NH
O
a bond
Q3a
OH


851
N
O
Q1f
a bond
Me
a bond
NH
O
a bond
Q3b
OH


852
N
O
Q1f
a bond
Me
a bond
NH
O
a bond
Q3c
OH


853
N
O
Q1f
a bond
H
a bond
NH
S
NH
Q3a
OH


854
N
O
Q1f
a bond
H
a bond
NH
S
NH
Q3b
OH


855
N
O
Q1f
a bond
H
a bond
NH
S
NH
Q3c
OH


856
N
O
Q1f
a bond
H
a bond
NH
S
a bond
Q3a
OH


857
N
O
Q1f
a bond
H
a bond
NH
S
a bond
Q3b
OH


858
N
O
Q1f
a bond
H
a bond
NH
S
a bond
Q3c
OH


859
N
O
Q1f
a bond
H
a bond
NH
O
NH
Q3a
OH


860
N
O
Q1f
a bond
H
a bond
NH
O
NH
Q3b
OH


861
N
O
Q1f
a bond
H
a bond
NH
O
NH
Q3c
OH


862
N
O
Q1f
a bond
H
a bond
NH
O
a bond
Q3a
OH


863
N
O
Q1f
a bond
H
a bond
NH
O
a bond
Q3b
OH


864
N
O
Q1f
a bond
H
a bond
NH
O
a bond
Q3c
OH


865
N
O
Q1g
a bond
Me
a bond
NH
S
NH
Q3a
OH


866
N
O
Q1g
a bond
Me
a bond
NH
S
NH
Q3b
OH


867
N
O
Q1g
a bond
Me
a bond
NH
S
NH
Q3c
OH


868
N
O
Q1g
a bond
Me
a bond
NH
S
a bond
Q3a
OH


869
N
O
Q1g
a bond
Me
a bond
NH
S
a bond
Q3b
OH


870
N
O
Q1g
a bond
Me
a bond
NH
S
a bond
Q3c
OH


871
N
O
Q1g
a bond
Me
a bond
NH
O
NH
Q3a
OH


872
N
O
Q1g
a bond
Me
a bond
NH
O
NH
Q3b
OH


873
N
O
Q1g
a bond
Me
a bond
NH
O
NH
Q3c
OH


874
N
O
Q1g
a bond
Me
a bond
NH
O
a bond
Q3a
OH


875
N
O
Q1g
a bond
Me
a bond
NH
O
a bond
Q3b
OH


876
N
O
Q1g
a bond
Me
a bond
NH
O
a bond
Q3c
OH


877
N
O
Q1g
a bond
H
a bond
NH
S
NH
Q3a
OH


878
N
O
Q1g
a bond
H
a bond
NH
S
NH
Q3b
OH


879
N
O
Q1g
a bond
H
a bond
NH
S
NH
Q3c
OH


880
N
O
Q1g
a bond
H
a bond
NH
S
a bond
Q3a
OH


881
N
O
Q1g
a bond
H
a bond
NH
S
a bond
Q3b
OH


882
N
O
Q1g
a bond
H
a bond
NH
S
a bond
Q3c
OH


883
N
O
Q1g
a bond
H
a bond
NH
O
NH
Q3a
OH


884
N
O
Q1g
a bond
H
a bond
NH
O
NH
Q3b
OH


885
N
O
Q1g
a bond
H
a bond
NH
O
NH
Q3c
OH


886
N
O
Q1g
a bond
H
a bond
NH
O
a bond
Q3a
OH


887
N
O
Q1g
a bond
H
a bond
NH
O
a bond
Q3b
OH


888
N
O
Q1g
a bond
H
a bond
NH
O
a bond
Q3c
OH


889
N
O
Q1h
a bond
Me
a bond
NH
S
NH
Q3a
OH


890
N
O
Q1h
a bond
Me
a bond
NH
S
NH
Q3b
OH


891
N
O
Q1h
a bond
Me
a bond
NH
S
NH
Q3c
OH


892
N
O
Q1h
a bond
Me
a bond
NH
S
a bond
Q3a
OH


893
N
O
Q1h
a bond
Me
a bond
NH
S
a bond
Q3b
OH


894
N
O
Q1h
a bond
Me
a bond
NH
S
a bond
Q3c
OH


895
N
O
Q1h
a bond
Me
a bond
NH
O
NH
Q3a
OH


896
N
O
Q1h
a bond
Me
a bond
NH
O
NH
Q3b
OH


897
N
O
Q1h
a bond
Me
a bond
NH
O
NH
Q3c
OH


898
N
O
Q1h
a bond
Me
a bond
NH
O
a bond
Q3a
OH


899
N
O
Q1h
a bond
Me
a bond
NH
O
a bond
Q3b
OH


900
N
O
Q1h
a bond
Me
a bond
NH
O
a bond
Q3c
OH


901
N
O
Q1h
a bond
H
a bond
NH
S
NH
Q3a
OH


902
N
O
Q1h
a bond
H
a bond
NH
S
NH
Q3b
OH


903
N
O
Q1h
a bond
H
a bond
NH
S
NH
Q3c
OH


904
N
O
Q1h
a bond
H
a bond
NH
S
a bond
Q3a
OH


905
N
O
Q1h
a bond
H
a bond
NH
S
a bond
Q3b
OH


906
N
O
Q1h
a bond
H
a bond
NH
S
a bond
Q3c
OH


907
N
O
Q1h
a bond
H
a bond
NH
O
NH
Q3a
OH


908
N
O
Q1h
a bond
H
a bond
NH
O
NH
Q3b
OH


909
N
O
Q1h
a bond
H
a bond
NH
O
NH
Q3c
OH


910
N
O
Q1h
a bond
H
a bond
NH
O
a bond
Q3a
OH


911
N
O
Q1h
a bond
H
a bond
NH
O
a bond
Q3b
OH


912
N
O
Q1h
a bond
H
a bond
NH
O
a bond
Q3c
OH


913
N
O
Q1i
a bond
Me
a bond
NH
S
NH
Q3a
OH


914
N
O
Q1i
a bond
Me
a bond
NH
S
NH
Q3b
OH


915
N
O
Q1i
a bond
Me
a bond
NH
S
NH
Q3c
OH


916
N
O
Q1i
a bond
Me
a bond
NH
S
a bond
Q3a
OH


917
N
O
Q1i
a bond
Me
a bond
NH
S
a bond
Q3b
OH


918
N
O
Q1i
a bond
Me
a bond
NH
S
a bond
Q3c
OH


919
N
O
Q1i
a bond
Me
a bond
NH
O
NH
Q3a
OH


920
N
O
Q1i
a bond
Me
a bond
NH
O
NH
Q3b
OH


921
N
O
Q1i
a bond
Me
a bond
NH
O
NH
Q3c
OH


922
N
O
Q1i
a bond
Me
a bond
NH
O
a bond
Q3a
OH


923
N
O
Q1i
a bond
Me
a bond
NH
O
a bond
Q3b
OH


924
N
O
Q1i
a bond
Me
a bond
NH
O
a bond
Q3c
OH


925
N
O
Q1i
a bond
H
a bond
NH
S
NH
Q3a
OH


926
N
O
Q1i
a bond
H
a bond
NH
S
NH
Q3b
OH


927
N
O
Q1i
a bond
H
a bond
NH
S
NH
Q3c
OH


928
N
O
Q1i
a bond
H
a bond
NH
S
a bond
Q3a
OH


929
N
O
Q1i
a bond
H
a bond
NH
S
a bond
Q3b
OH


930
N
O
Q1i
a bond
H
a bond
NH
S
a bond
Q3c
OH


931
N
O
Q1i
a bond
H
a bond
NH
O
NH
Q3a
OH


932
N
O
Q1i
a bond
H
a bond
NH
O
NH
Q3b
OH


933
N
O
Q1i
a bond
H
a bond
NH
O
NH
Q3c
OH


934
N
O
Q1i
a bond
H
a bond
NH
O
a bond
Q3a
OH


935
N
O
Q1i
a bond
H
a bond
NH
O
a bond
Q3b
OH


936
N
O
Q1i
a bond
H
a bond
NH
O
a bond
Q3c
OH


937
N
O
Q1j
a bond
Me
a bond
NH
S
NH
Q3a
OH


938
N
O
Q1j
a bond
Me
a bond
NH
S
NH
Q3b
OH


939
N
O
Q1j
a bond
Me
a bond
NH
S
NH
Q3c
OH


940
N
O
Q1j
a bond
Me
a bond
NH
S
a bond
Q3a
OH


941
N
O
Q1j
a bond
Me
a bond
NH
S
a bond
Q3b
OH


942
N
O
Q1j
a bond
Me
a bond
NH
S
a bond
Q3c
OH


943
N
O
Q1j
a bond
Me
a bond
NH
O
NH
Q3a
OH


944
N
O
Q1j
a bond
Me
a bond
NH
O
NH
Q3b
OH


945
N
O
Q1j
a bond
Me
a bond
NH
O
NH
Q3c
OH


946
N
O
Q1j
a bond
Me
a bond
NH
O
a bond
Q3a
OH


947
N
O
Q1j
a bond
Me
a bond
NH
O
a bond
Q3b
OH


948
N
O
Q1j
a bond
Me
a bond
NH
O
a bond
Q3c
OH


949
N
O
Q1j
a bond
H
a bond
NH
S
NH
Q3a
OH


950
N
O
Q1j
a bond
H
a bond
NH
S
NH
Q3b
OH


951
N
O
Q1j
a bond
H
a bond
NH
S
NH
Q3c
OH


952
N
O
Q1j
a bond
H
a bond
NH
S
a bond
Q3a
OH


953
N
O
Q1j
a bond
H
a bond
NH
S
a bond
Q3b
OH


954
N
O
Q1j
a bond
H
a bond
NH
S
a bond
Q3c
OH


955
N
O
Q1j
a bond
H
a bond
NH
O
NH
Q3a
OH


956
N
O
Q1j
a bond
H
a bond
NH
O
NH
Q3b
OH


957
N
O
Q1j
a bond
H
a bond
NH
O
NH
Q3c
OH


958
N
O
Q1j
a bond
H
a bond
NH
O
a bond
Q3a
OH


959
N
O
Q1j
a bond
H
a bond
NH
O
a bond
Q3b
OH


960
N
O
Q1j
a bond
H
a bond
NH
O
a bond
Q3c
OH


961
CH
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3a
OH


962
CH
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3b
OH


963
CH
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3c
OH


964
CH
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
Q3a
OH


965
CH
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
Q3b
OH


966
CH
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
Q3c
OH


967
CH
NMe
Q1a
a bond
Me
a bond
NH
O
NH
Q3a
OH


968
CH
NMe
Q1a
a bond
Me
a bond
NH
O
NH
Q3b
OH


969
CH
NMe
Q1a
a bond
Me
a bond
NH
O
NH
Q3c
OH


970
CH
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3a
OH


971
CH
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3b
OH


972
CH
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3c
OH


973
CH
NMe
Q1a
a bond
H
a bond
NH
S
NH
Q3a
OH


974
CH
NMe
Q1a
a bond
H
a bond
NH
S
NH
Q3b
OH


975
CH
NMe
Q1a
a bond
H
a bond
NH
S
NH
Q3c
OH


976
CH
NMe
Q1a
a bond
H
a bond
NH
S
a bond
Q3a
OH


977
CH
NMe
Q1a
a bond
H
a bond
NH
S
a bond
Q3b
OH


978
CH
NMe
Q1a
a bond
H
a bond
NH
S
a bond
Q3c
OH


979
CH
NMe
Q1a
a bond
H
a bond
NH
O
NH
Q3a
OH


980
CH
NMe
Q1a
a bond
H
a bond
NH
O
NH
Q3b
OH


981
CH
NMe
Q1a
a bond
H
a bond
NH
O
NH
Q3c
OH


982
CH
NMe
Q1a
a bond
H
a bond
NH
O
a bond
Q3a
OH


983
CH
NMe
Q1a
a bond
H
a bond
NH
O
a bond
Q3b
OH


984
CH
NMe
Q1a
a bond
H
a bond
NH
O
a bond
Q3c
OH


985
CH
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3a
OH


986
CH
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3b
OH


987
CH
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3c
OH


988
CH
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
Q3a
OH


989
CH
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
Q3b
OH


990
CH
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
Q3c
OH


991
CH
NMe
Q1b
a bond
Me
a bond
NH
O
NH
Q3a
OH


992
CH
NMe
Q1b
a bond
Me
a bond
NH
O
NH
Q3b
OH


993
CH
NMe
Q1b
a bond
Me
a bond
NH
O
NH
Q3c
OH


994
CH
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3a
OH


995
CH
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3b
OH


996
CH
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3c
OH


997
CH
NMe
Q1b
a bond
H
a bond
NH
S
NH
Q3a
OH


998
CH
NMe
Q1b
a bond
H
a bond
NH
S
NH
Q3b
OH


999
CH
NMe
Q1b
a bond
H
a bond
NH
S
NH
Q3c
OH


1000
CH
NMe
Q1b
a bond
H
a bond
NH
S
a bond
Q3a
OH


1001
CH
NMe
Q1b
a bond
H
a bond
NH
S
a bond
Q3b
OH


1002
CH
NMe
Q1b
a bond
H
a bond
NH
S
a bond
Q3c
OH


1003
CH
NMe
Q1b
a bond
H
a bond
NH
O
NH
Q3a
OH


1004
CH
NMe
Q1b
a bond
H
a bond
NH
O
NH
Q3b
OH


1005
CH
NMe
Q1b
a bond
H
a bond
NH
O
NH
Q3c
OH


1006
CH
NMe
Q1b
a bond
H
a bond
NH
O
a bond
Q3a
OH


1007
CH
NMe
Q1b
a bond
H
a bond
NH
O
a bond
Q3b
OH


1008
CH
NMe
Q1b
a bond
H
a bond
NH
O
a bond
Q3c
OH


1009
CH
NMe
Qic
a bond
Me
a bond
NH
S
NH
Q3a
OH


1010
CH
NMe
Qic
a bond
Me
a bond
NH
S
NH
Q3b
OH


1011
CH
NMe
Qic
a bond
Me
a bond
NH
S
NH
Q3c
OH


1012
CH
NMe
Qic
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1013
CH
NMe
Qic
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1014
CH
NMe
Qic
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1015
CH
NMe
Qic
a bond
Me
a bond
NH
O
NH
Q3a
OH


1016
CH
NMe
Qic
a bond
Me
a bond
NH
O
NH
Q3b
OH


1017
CH
NMe
Qic
a bond
Me
a bond
NH
O
NH
Q3c
OH


1018
CH
NMe
Qic
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1019
CH
NMe
Qic
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1020
CH
NMe
Qic
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1021
CH
NMe
Q1c
a bond
H
a bond
NH
S
NH
Q3a
OH


1022
CH
NMe
Q1c
a bond
H
a bond
NH
S
NH
Q3b
OH


1023
CH
NMe
Q1c
a bond
H
a bond
NH
S
NH
Q3c
OH


1024
CH
NMe
Q1c
a bond
H
a bond
NH
S
a bond
Q3a
OH


1025
CH
NMe
Q1c
a bond
H
a bond
NH
S
a bond
Q3b
OH


1026
CH
NMe
Q1c
a bond
H
a bond
NH
S
a bond
Q3c
OH


1027
CH
NMe
Q1c
a bond
H
a bond
NH
O
NH
Q3a
OH


1028
CH
NMe
Q1c
a bond
H
a bond
NH
O
NH
Q3b
OH


1029
CH
NMe
Q1c
a bond
H
a bond
NH
O
NH
Q3c
OH


1030
CH
NMe
Q1c
a bond
H
a bond
NH
O
a bond
Q3a
OH


1031
CH
NMe
Q1c
a bond
H
a bond
NH
O
a bond
Q3b
OH


1032
CH
NMe
Q1c
a bond
H
a bond
NH
O
a bond
Q3c
OH


1033
CH
NMe
Qid
a bond
Me
a bond
NH
S
NH
Q3a
OH


1034
CH
NMe
Qid
a bond
Me
a bond
NH
S
NH
Q3b
OH


1035
CH
NMe
Qid
a bond
Me
a bond
NH
S
NH
Q3c
OH


1036
CH
NMe
Qid
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1037
CH
NMe
Qid
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1038
CH
NMe
Qid
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1039
CH
NMe
Qid
a bond
Me
a bond
NH
O
NH
Q3a
OH


1040
CH
NMe
Qid
a bond
Me
a bond
NH
O
NH
Q3b
QH


1041
CH
NMe
Qid
a bond
Me
a bond
NH
O
NH
Q3c
OH


1042
CH
NMe
Qid
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1043
CH
NMe
Qid
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1044
CH
NMe
Qid
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1045
CH
NMe
Q1d
a bond
H
a bond
NH
S
NH
Q3a
OH


1046
CH
NMe
Q1d
a bond
H
a bond
NH
S
NH
Q3b
OH


1047
CH
NMe
Q1d
a bond
H
a bond
NH
S
NH
Q3c
OH


1048
CH
NMe
Q1d
a bond
H
a bond
NH
S
a bond
Q3a
OH


1049
CH
NMe
Q1d
a bond
H
a bond
NH
S
a bond
Q3b
OH


1050
CH
NMe
Q1d
a bond
H
a bond
NH
S
a bond
Q3c
OH


1051
CH
NMe
Q1d
a bond
H
a bond
NH
O
NH
Q3a
OH


1052
CH
NMe
Q1d
a bond
H
a bond
NH
O
NH
Q3b
OH


1053
CH
NMe
Q1d
a bond
H
a bond
NH
O
NH
Q3c
OH


1054
CH
NMe
Q1d
a bond
H
a bond
NH
O
a bond
Q3a
OH


1055
CH
NMe
Q1d
a bond
H
a bond
NH
O
a bond
Q3b
OH


1056
CH
NMe
Q1d
a bond
H
a bond
NH
O
a bond
Q3c
OH


1057
CH
NMe
Q1e
a bond
Me
a bond
NH
S
NH
Q3a
OH


1058
CH
NMe
Q1e
a bond
Me
a bond
NH
S
NH
Q3b
OH


1059
CH
NMe
Q1e
a bond
Me
a bond
NH
S
NH
Q3c
OH


1060
CH
NMe
Q1e
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1061
CH
NMe
Q1e
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1062
CH
NMe
Q1e
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1063
CH
NMe
Q1e
a bond
Me
a bond
NH
O
NH
Q3a
OH


1064
CH
NMe
Q1e
a bond
Me
a bond
NH
O
NH
Q3b
OH


1065
CH
NMe
Q1e
a bond
Me
a bond
NH
O
NH
Q3c
OH


1066
CH
NMe
Q1e
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1067
CH
NMe
Q1e
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1068
CH
NMe
Q1e
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1069
CH
NMe
Q1e
a bond
H
a bond
NH
S
NH
Q3a
OH


1070
CH
NMe
Q1e
a bond
H
a bond
NH
S
NH
Q3b
OH


1071
CH
NMe
Q1e
a bond
H
a bond
NH
S
NH
Q3c
OH


1072
CH
NMe
Q1e
a bond
H
a bond
NH
S
a bond
Q3a
OH


1073
CH
NMe
Q1e
a bond
H
a bond
NH
S
a bond
Q3b
OH


1074
CH
NMe
Q1e
a bond
H
a bond
NH
S
a bond
Q3c
OH


1075
CH
NMe
Q1e
a bond
H
a bond
NH
O
NH
Q3a
OH


1076
CH
NMe
Q1e
a bond
H
a bond
NH
O
NH
Q3b
OH


1077
CH
NMe
Q1e
a bond
H
a bond
NH
O
NH
Q3c
OH


1078
CH
NMe
Q1e
a bond
H
a bond
NH
O
a bond
Q3a
OH


1079
CH
NMe
Q1e
a bond
H
a bond
NH
O
a bond
Q3b
OH


1080
CH
NMe
Q1e
a bond
H
a bond
NH
O
a bond
Q3c
OH


1081
CH
NMe
Q1f
a bond
Me
a bond
NH
S
NH
Q3a
OH


1082
CH
NMe
Q1f
a bond
Me
a bond
NH
S
NH
Q3b
OH


1083
CH
NMe
Q1f
a bond
Me
a bond
NH
S
NH
Q3c
OH


1084
CH
NMe
Q1f
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1085
CH
NMe
Q1f
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1086
CH
NMe
Q1f
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1087
CH
NMe
Q1f
a bond
Me
a bond
NH
O
NH
Q3a
OH


1088
CH
NMe
Q1f
a bond
Me
a bond
NH
O
NH
Q3b
OH


1089
CH
NMe
Q1f
a bond
Me
a bond
NH
O
NH
Q3c
OH


1090
CH
NMe
Q1f
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1091
CH
NMe
Q1f
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1092
CH
NMe
Q1f
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1093
CH
NMe
Q1f
a bond
H
a bond
NH
S
NH
Q3a
OH


1094
CH
NMe
Q1f
a bond
H
a bond
NH
S
NH
Q3b
OH


1095
CH
NMe
Q1f
a bond
H
a bond
NH
S
NH
Q3c
OH


1096
CH
NMe
Q1f
a bond
H
a bond
NH
S
a bond
Q3a
OH


1097
CH
NMe
Q1f
a bond
H
a bond
NH
S
a bond
Q3b
OH


1098
CH
NMe
Q1f
a bond
H
a bond
NH
S
a bond
Q3c
OH


1099
CH
NMe
Q1f
a bond
H
a bond
NH
O
NH
Q3a
OH


1100
CH
NMe
Q1f
a bond
H
a bond
NH
O
NH
Q3b
OH


1101
CH
NMe
Q1f
a bond
H
a bond
NH
O
NH
Q3c
OH


1102
CH
NMe
Q1f
a bond
H
a bond
NH
O
a bond
Q3a
OH


1103
CH
NMe
Q1f
a bond
H
a bond
NH
O
a bond
Q3b
OH


1104
CH
NMe
Q1f
a bond
H
a bond
NH
O
a bond
Q3c
OH


1105
CH
NMe
Q1g
a bond
Me
a bond
NH
S
NH
Q3a
OH


1106
CH
NMe
Q1g
a bond
Me
a bond
NH
S
NH
Q3b
OH


1107
CH
NMe
Q1g
a bond
Me
a bond
NH
S
NH
Q3c
OH


1108
CH
NMe
Q1g
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1109
CH
NMe
Q1g
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1110
CH
NMe
Q1g
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1111
CH
NMe
Q1g
a bond
Me
a bond
NH
O
NH
Q3a
OH


1112
CH
NMe
Q1g
a bond
Me
a bond
NH
O
NH
Q3b
OH


1113
CH
NMe
Q1g
a bond
Me
a bond
NH
O
NH
Q3c
OH


1114
CH
NMe
Q1g
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1115
CH
NMe
Q1g
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1116
CH
NMe
Q1g
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1117
CH
NMe
Q1g
a bond
H
a bond
NH
S
NH
Q3a
OH


1118
CH
NMe
Q1g
a bond
H
a bond
NH
S
NH
Q3b
OH


1119
CH
NMe
Q1g
a bond
H
a bond
NH
S
NH
Q3c
OH


1120
CH
NMe
Q1g
a bond
H
a bond
NH
S
a bond
Q3a
OH


1121
CH
NMe
Q1g
a bond
H
a bond
NH
S
a bond
Q3b
OH


1122
CH
NMe
Q1g
a bond
H
a bond
NH
S
a bond
Q3c
OH


1123
CH
NMe
Q1g
a bond
H
a bond
NH
O
NH
Q3a
OH


1124
CH
NMe
Q1g
a bond
H
a bond
NH
O
NH
Q3b
OH


1125
CH
NMe
Q1g
a bond
H
a bond
NH
O
NH
Q3c
OH


1126
CH
NMe
Q1g
a bond
H
a bond
NH
O
a bond
Q3a
OH


1127
CH
NMe
Q1g
a bond
H
a bond
NH
O
a bond
Q3b
OH


1128
CH
NMe
Q1g
a bond
H
a bond
NH
O
a bond
Q3c
OH


1129
CH
NMe
Q1h
a bond
Me
a bond
NH
S
NH
Q3a
OH


1130
CH
NMe
Q1h
a bond
Me
a bond
NH
S
NH
Q3b
OH


1131
CH
NMe
Q1h
a bond
Me
a bond
NH
S
NH
Q3c
OH


1132
CH
NMe
Q1h
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1133
CH
NMe
Q1h
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1134
CH
NMe
Q1h
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1135
CH
NMe
Q1h
a bond
Me
a bond
NH
O
NH
Q3a
OH


1136
CH
NMe
Q1h
a bond
Me
a bond
NH
O
NH
Q3b
OH


1137
CH
NMe
Q1h
a bond
Me
a bond
NH
O
NH
Q3c
OH


1138
CH
NMe
Q1h
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1139
CH
NMe
Q1h
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1140
CH
NMe
Q1h
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1141
CH
NMe
Q1h
a bond
H
a bond
NH
S
NH
Q3a
OH


1142
CH
NMe
Q1h
a bond
H
a bond
NH
S
NH
Q3b
OH


1143
CH
NMe
Q1h
a bond
H
a bond
NH
S
NH
Q3c
OH


1144
CH
NMe
Q1h
a bond
H
a bond
NH
S
a bond
Q3a
OH


1145
CH
NMe
Q1h
a bond
H
a bond
NH
S
a bond
Q3b
OH


1146
CH
NMe
Q1h
a bond
H
a bond
NH
S
a bond
Q3c
OH


1147
CH
NMe
Q1h
a bond
H
a bond
NH
O
NH
Q3a
OH


1148
CH
NMe
Q1h
a bond
H
a bond
NH
O
NH
Q3b
OH


1149
CH
NMe
Q1h
a bond
H
a bond
NH
O
NH
Q3c
OH


1150
CH
NMe
Q1h
a bond
H
a bond
NH
O
a bond
Q3a
OH


1151
CH
NMe
Q1h
a bond
H
a bond
NH
O
a bond
Q3b
OH


1152
CH
NMe
Q1h
a bond
H
a bond
NH
O
a bond
Q3c
OH


1153
CH
NMe
Q1i
a bond
Me
a bond
NH
S
NH
Q3a
OH


1154
CH
NMe
Q1i
a bond
Me
a bond
NH
S
NH
Q3b
OH


1155
CH
NMe
Q1i
a bond
Me
a bond
NH
S
NH
Q3c
OH


1156
CH
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1157
CH
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1158
CH
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1159
CH
NMe
Q1i
a bond
Me
a bond
NH
O
NH
Q3a
OH


1160
CH
NMe
Q1i
a bond
Me
a bond
NH
O
NH
Q3b
OH


1161
CH
NMe
Q1i
a bond
Me
a bond
NH
O
NH
Q3c
OH


1162
CH
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1163
CH
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1164
CH
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1165
CH
NMe
Q1i
a bond
H
a bond
NH
S
NH
Q3a
OH


1166
CH
NMe
Q1i
a bond
H
a bond
NH
S
NH
Q3b
OH


1167
CH
NMe
Q1i
a bond
H
a bond
NH
S
NH
Q3c
OH


1168
CH
NMe
Q1i
a bond
H
a bond
NH
S
a bond
Q3a
OH


1169
CH
NMe
Q1i
a bond
H
a bond
NH
S
a bond
Q3b
OH


1170
CH
NMe
Q1i
a bond
H
a bond
NH
S
a bond
Q3c
OH


1171
CH
NMe
Q1i
a bond
H
a bond
NH
O
NH
Q3a
OH


1172
CH
NMe
Q1i
a bond
H
a bond
NH
O
NH
Q3b
OH


1173
CH
NMe
Q1i
a bond
H
a bond
NH
O
NH
Q3c
OH


1174
CH
NMe
Q1i
a bond
H
a bond
NH
O
a bond
Q3a
OH


1175
CH
NMe
Q1i
a bond
H
a bond
NH
O
a bond
Q3b
OH


1176
CH
NMe
Q1i
a bond
H
a bond
NH
O
a bond
Q3c
OH


1177
CH
NMe
Q1j
a bond
Me
a bond
NH
S
NH
Q3a
OH


1178
CH
NMe
Q1j
a bond
Me
a bond
NH
S
NH
Q3b
OH


1179
CH
NMe
Q1j
a bond
Me
a bond
NH
S
NH
Q3c
OH


1180
CH
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1181
CH
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1182
CH
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1183
CH
NMe
Q1j
a bond
Me
a bond
NH
O
NH
Q3a
OH


1184
CH
NMe
Q1j
a bond
Me
a bond
NH
O
NH
Q3b
OH


1185
CH
NMe
Q1j
a bond
Me
a bond
NH
O
NH
Q3c
OH


1186
CH
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1187
CH
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1188
CH
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1189
CH
NMe
Q1j
a bond
H
a bond
NH
S
NH
Q3a
OH


1190
CH
NMe
Q1j
a bond
H
a bond
NH
S
NH
Q3b
OH


1191
CH
NMe
Q1j
a bond
H
a bond
NH
S
NH
Q3c
OH


1192
CH
NMe
Q1j
a bond
H
a bond
NH
S
a bond
Q3a
OH


1193
CH
NMe
Q1j
a bond
H
a bond
NH
S
a bond
Q3b
OH


1194
CH
NMe
Q1j
a bond
H
a bond
NH
S
a bond
Q3c
OH


1195
CH
NMe
Q1j
a bond
H
a bond
NH
O
NH
Q3a
OH


1196
CH
NMe
Q1j
a bond
H
a bond
NH
O
NH
Q3b
OH


1197
CH
NMe
Q1j
a bond
H
a bond
NH
O
NH
Q3c
OH


1198
CH
NMe
Q1j
a bond
H
a bond
NH
O
a bond
Q3a
OH


1199
CH
NMe
Q1j
a bond
H
a bond
NH
O
a bond
Q3b
OH


1200
CH
NMe
Q1j
a bond
H
a bond
NH
O
a bond
Q3c
OH


1201
CH
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3a
OH


1202
CH
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3b
OH


1203
CH
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3c
OH


1204
CH
NEt
Q1a
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1205
CH
NEt
Q1a
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1206
CH
NEt
Q1a
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1207
CH
NEt
Q1a
a bond
Me
a bond
NH
O
NH
Q3a
OH


1208
CH
NEt
Q1a
a bond
Me
a bond
NH
O
NH
Q3b
OH


1209
CH
NEt
Q1a
a bond
Me
a bond
NH
O
NH
Q3c
OH


1210
CH
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1211
CH
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1212
CH
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1213
CH
NEt
Q1a
a bond
H
a bond
NH
S
NH
Q3a
OH


1214
CH
NEt
Q1a
a bond
H
a bond
NH
S
NH
Q3b
OH


1215
CH
NEt
Q1a
a bond
H
a bond
NH
S
NH
Q3c
OH


1216
CH
NEt
Q1a
a bond
H
a bond
NH
S
a bond
Q3a
OH


1217
CH
NEt
Q1a
a bond
H
a bond
NH
S
a bond
Q3b
OH


1218
CH
NEt
Q1a
a bond
H
a bond
NH
S
a bond
Q3c
OH


1219
CH
NEt
Q1a
a bond
H
a bond
NH
O
NH
Q3a
OH


1220
CH
NEt
Q1a
a bond
H
a bond
NH
O
NH
Q3b
OH


1221
CH
NEt
Q1a
a bond
H
a bond
NH
O
NH
Q3c
OH


1222
CH
NEt
Q1a
a bond
H
a bond
NH
O
a bond
Q3a
OH


1223
CH
NEt
Q1a
a bond
H
a bond
NH
O
a bond
Q3b
OH


1224
CH
NEt
Q1a
a bond
H
a bond
NH
O
a bond
Q3c
OH


1225
CH
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3a
OH


1226
CH
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3b
OH


1227
CH
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3c
OH


1228
CH
NEt
Q1b
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1229
CH
NEt
Q1b
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1230
CH
NEt
Q1b
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1231
CH
NEt
Q1b
a bond
Me
a bond
NH
O
NH
Q3a
OH


1232
CH
NEt
Q1b
a bond
Me
a bond
NH
O
NH
Q3b
OH


1233
CH
NEt
Q1b
a bond
Me
a bond
NH
O
NH
Q3c
OH


1234
CH
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1235
CH
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1236
CH
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1237
CH
NEt
Q1b
a bond
H
a bond
NH
S
NH
Q3a
OH


1238
CH
NEt
Q1b
a bond
H
a bond
NH
S
NH
Q3b
OH


1239
CH
NEt
Q1b
a bond
H
a bond
NH
S
NH
Q3c
OH


1240
CH
NEt
Q1b
a bond
H
a bond
NH
S
a bond
Q3a
OH


1241
CH
NEt
Q1b
a bond
H
a bond
NH
S
a bond
Q3b
OH


1242
CH
NEt
Q1b
a bond
H
a bond
NH
S
a bond
Q3c
OH


1243
CH
NEt
Q1b
a bond
H
a bond
NH
O
NH
Q3a
OH


1244
CH
NEt
Q1b
a bond
H
a bond
NH
O
NH
Q3b
OH


1245
CH
NEt
Q1b
a bond
H
a bond
NH
O
NH
Q3c
OH


1246
CH
NEt
Q1b
a bond
H
a bond
NH
O
a bond
Q3a
OH


1247
CH
NEt
Q1b
a bond
H
a bond
NH
O
a bond
Q3b
OH


1248
CH
NEt
Q1b
a bond
H
a bond
NH
O
a bond
Q3c
OH


1249
CH
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3a
OH


1250
CH
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3b
OH


1251
CH
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3c
OH


1252
CH
NEt
Q1c
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1253
CH
NEt
Q1c
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1254
CH
NEt
Q1c
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1255
CH
NEt
Q1c
a bond
Me
a bond
NH
O
NH
Q3a
OH


1256
CH
NEt
Q1c
a bond
Me
a bond
NH
O
NH
Q3b
OH


1257
CH
NEt
Q1c
a bond
Me
a bond
NH
O
NH
Q3c
OH


1258
CH
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1259
CH
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1260
CH
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1261
CH
NEt
Q1c
a bond
H
a bond
NH
S
NH
Q3a
OH


1262
CH
NEt
Q1c
a bond
H
a bond
NH
S
NH
Q3b
OH


1263
CH
NEt
Q1c
a bond
H
a bond
NH
S
NH
Q3c
OH


1264
CH
NEt
Q1c
a bond
H
a bond
NH
S
a bond
Q3a
OH


1265
CH
NEt
Q1c
a bond
H
a bond
NH
S
a bond
Q3b
OH


1266
CH
NEt
Q1c
a bond
H
a bond
NH
S
a bond
Q3c
OH


1267
CH
NEt
Q1c
a bond
H
a bond
NH
O
NH
Q3a
OH


1268
CH
NEt
Q1c
a bond
H
a bond
NH
O
NH
Q3b
OH


1269
CH
NEt
Q1c
a bond
H
a bond
NH
O
NH
Q3c
OH


1270
CH
NEt
Q1c
a bond
H
a bond
NH
O
a bond
Q3a
OH


1271
CH
NEt
Q1c
a bond
H
a bond
NH
O
a bond
Q3b
OH


1272
CH
NEt
Q1c
a bond
H
a bond
NH
O
a bond
Q3c
OH


1273
CH
NEt
Q1d
a bond
Me
a bond
NH
S
NH
Q3a
OH


1274
CH
NEt
Q1d
a bond
Me
a bond
NH
S
NH
Q3b
OH


1275
CH
NEt
Q1d
a bond
Me
a bond
NH
S
NH
Q3c
OH


1276
CH
NEt
Q1d
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1277
CH
NEt
Q1d
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1278
CH
NEt
Q1d
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1279
CH
NEt
Q1d
a bond
Me
a bond
NH
O
NH
Q3a
OH


1280
CH
NEt
Q1d
a bond
Me
a bond
NH
O
NH
Q3b
OH


1281
CH
NEt
Q1d
a bond
Me
a bond
NH
O
NH
Q3c
OH


1282
CH
NEt
Q1d
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1283
CH
NEt
Q1d
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1284
CH
NEt
Q1d
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1285
CH
NEt
Q1d
a bond
H
a bond
NH
S
NH
Q3a
OH


1286
CH
NEt
Q1d
a bond
H
a bond
NH
S
NH
Q3b
OH


1287
CH
NEt
Q1d
a bond
H
a bond
NH
S
NH
Q3c
OH


1288
CH
NEt
Q1d
a bond
H
a bond
NH
S
a bond
Q3a
OH


1289
CH
NEt
Q1d
a bond
H
a bond
NH
S
a bond
Q3b
OH


1290
CH
NEt
Q1d
a bond
H
a bond
NH
S
a bond
Q3c
OH


1291
CH
NEt
Q1d
a bond
H
a bond
NH
O
NH
Q3a
OH


1292
CH
NEt
Q1d
a bond
H
a bond
NH
O
NH
Q3b
OH


1293
CH
NEt
Q1d
a bond
H
a bond
NH
O
NH
Q3c
OH


1294
CH
NEt
Q1d
a bond
H
a bond
NH
O
a bond
Q3a
OH


1295
CH
NEt
Q1d
a bond
H
a bond
NH
O
a bond
Q3b
OH


1296
CH
NEt
Q1d
a bond
H
a bond
NH
O
a bond
Q3c
OH


1297
CH
NEt
Q1e
a bond
Me
a bond
NH
S
NH
Q3a
OH


1298
CH
NEt
Q1e
a bond
Me
a bond
NH
S
NH
Q3b
OH


1299
CH
NEt
Q1e
a bond
Me
a bond
NH
S
NH
Q3c
OH


1300
CH
NEt
Q1e
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1301
CH
NEt
Q1e
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1302
CH
NEt
Q1e
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1303
CH
NEt
Q1e
a bond
Me
a bond
NH
O
NH
Q3a
OH


1304
CH
NEt
Q1e
a bond
Me
a bond
NH
O
NH
Q3b
OH


1305
CH
NEt
Q1e
a bond
Me
a bond
NH
O
NH
Q3c
OH


1306
CH
NEt
Q1e
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1307
CH
NEt
Q1e
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1308
CH
NEt
Q1e
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1309
CH
NEt
Q1e
a bond
H
a bond
NH
S
NH
Q3a
OH


1310
CH
NEt
Q1e
a bond
H
a bond
NH
S
NH
Q3b
OH


1311
CH
NEt
Q1e
a bond
H
a bond
NH
S
NH
Q3c
OH


1312
CH
NEt
Q1e
a bond
H
a bond
NH
S
a bond
Q3a
OH


1313
CH
NEt
Q1e
a bond
H
a bond
NH
S
a bond
Q3b
OH


1314
CH
NEt
Q1e
a bond
H
a bond
NH
S
a bond
Q3c
OH


1315
CH
NEt
Q1e
a bond
H
a bond
NH
O
NH
Q3a
OH


1316
CH
NEt
Q1e
a bond
H
a bond
NH
O
NH
Q3b
OH


1317
CH
NEt
Q1e
a bond
H
a bond
NH
O
NH
Q3c
OH


1318
CH
NEt
Q1e
a bond
H
a bond
NH
O
a bond
Q3a
OH


1319
CH
NEt
Q1e
a bond
H
a bond
NH
O
a bond
Q3b
OH


1320
CH
NEt
Q1e
a bond
H
a bond
NH
O
a bond
Q3c
OH


1321
CH
NEt
Q1f
a bond
Me
a bond
NH
S
NH
Q3a
OH


1322
CH
NEt
Q1f
a bond
Me
a bond
NH
S
NH
Q3b
OH


1323
CH
NEt
Q1f
a bond
Me
a bond
NH
S
NH
Q3c
OH


1324
CH
NEt
Q1f
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1325
CH
NEt
Q1f
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1326
CH
NEt
Q1f
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1327
CH
NEt
Q1f
a bond
Me
a bond
NH
O
NH
Q3a
OH


1328
CH
NEt
Q1f
a bond
Me
a bond
NH
O
NH
Q3b
OH


1329
CH
NEt
Q1f
a bond
Me
a bond
NH
O
NH
Q3c
OH


1330
CH
NEt
Q1f
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1331
CH
NEt
Q1f
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1332
CH
NEt
Q1f
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1333
CH
NEt
Q1f
a bond
H
a bond
NH
S
NH
Q3a
OH


1334
CH
NEt
Q1f
a bond
H
a bond
NH
S
NH
Q3b
OH


1335
CH
NEt
Q1f
a bond
H
a bond
NH
S
NH
Q3c
OH


1336
CH
NEt
Q1f
a bond
H
a bond
NH
S
a bond
Q3a
OH


1337
CH
NEt
Q1f
a bond
H
a bond
NH
S
a bond
Q3b
OH


1338
CH
NEt
Q1f
a bond
H
a bond
NH
S
a bond
Q3c
OH


1339
CH
NEt
Q1f
a bond
H
a bond
NH
O
NH
Q3a
OH


1340
CH
NEt
Q1f
a bond
H
a bond
NH
O
NH
Q3b
OH


1341
CH
NEt
Q1f
a bond
H
a bond
NH
O
NH
Q3c
OH


1342
CH
NEt
Q1f
a bond
H
a bond
NH
O
a bond
Q3a
OH


1343
CH
NEt
Q1f
a bond
H
a bond
NH
O
a bond
Q3b
OH


1344
CH
NEt
Q1f
a bond
H
a bond
NH
O
a bond
Q3c
OH


1345
CH
NEt
Q1g
a bond
Me
a bond
NH
S
NH
Q3a
OH


1346
CH
NEt
Q1g
a bond
Me
a bond
NH
S
NH
Q3b
OH


1347
CH
NEt
Q1g
a bond
Me
a bond
NH
S
NH
Q3c
OH


1348
CH
NEt
Q1g
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1349
CH
NEt
Q1g
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1350
CH
NEt
Q1g
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1351
CH
NEt
Q1g
a bond
Me
a bond
NH
O
NH
Q3a
OH


1352
CH
NEt
Q1g
a bond
Me
a bond
NH
O
NH
Q3b
OH


1353
CH
NEt
Q1g
a bond
Me
a bond
NH
O
NH
Q3c
OH


1354
CH
NEt
Q1g
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1355
CH
NEt
Q1g
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1356
CH
NEt
Q1g
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1357
CH
NEt
Q1g
a bond
H
a bond
NH
S
NH
Q3a
OH


1358
CH
NEt
Q1g
a bond
H
a bond
NH
S
NH
Q3b
OH


1359
CH
NEt
Q1g
a bond
H
a bond
NH
S
NH
Q3c
OH


1360
CH
NEt
Q1g
a bond
H
a bond
NH
S
a bond
Q3a
OH


1361
CH
NEt
Q1g
a bond
H
a bond
NH
S
a bond
Q3b
OH


1362
CH
NEt
Q1g
a bond
H
a bond
NH
S
a bond
Q3c
OH


1363
CH
NEt
Q1g
a bond
H
a bond
NH
O
NH
Q3a
OH


1364
CH
NEt
Q1g
a bond
H
a bond
NH
O
NH
Q3b
OH


1365
CH
NEt
Q1g
a bond
H
a bond
NH
O
NH
Q3c
OH


1366
CH
NEt
Q1g
a bond
H
a bond
NH
O
a bond
Q3a
OH


1367
CH
NEt
Q1g
a bond
H
a bond
NH
O
a bond
Q3b
OH


1368
CH
NEt
Q1g
a bond
H
a bond
NH
O
a bond
Q3c
OH


1369
CH
NEt
Q1h
a bond
Me
a bond
NH
S
NH
Q3a
OH


1370
CH
NEt
Q1h
a bond
Me
a bond
NH
S
NH
Q3b
OH


1371
CH
NEt
Q1h
a bond
Me
a bond
NH
S
NH
Q3c
OH


1372
CH
NEt
Q1h
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1373
CH
NEt
Q1h
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1374
CH
NEt
Q1h
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1375
CH
NEt
Q1h
a bond
Me
a bond
NH
O
NH
Q3a
OH


1376
CH
NEt
Q1h
a bond
Me
a bond
NH
O
NH
Q3b
OH


1377
CH
NEt
Q1h
a bond
Me
a bond
NH
O
NH
Q3c
OH


1378
CH
NEt
Q1h
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1379
CH
NEt
Q1h
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1380
CH
NEt
Q1h
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1381
CH
NEt
Q1h
a bond
H
a bond
NH
S
NH
Q3a
OH


1382
CH
NEt
Q1h
a bond
H
a bond
NH
S
NH
Q3b
OH


1383
CH
NEt
Q1h
a bond
H
a bond
NH
S
NH
Q3c
OH


1384
CH
NEt
Q1h
a bond
H
a bond
NH
S
a bond
Q3a
OH


1385
CH
NEt
Q1h
a bond
H
a bond
NH
S
a bond
Q3b
OH


1386
CH
NEt
Q1h
a bond
H
a bond
NH
S
a bond
Q3c
OH


1387
CH
NEt
Q1h
a bond
H
a bond
NH
O
NH
Q3a
OH


1388
CH
NEt
Q1h
a bond
H
a bond
NH
O
NH
Q3b
OH


1389
CH
NEt
Q1h
a bond
H
a bond
NH
O
NH
Q3c
OH


1390
CH
NEt
Q1h
a bond
H
a bond
NH
O
a bond
Q3a
OH


1391
CH
NEt
Q1h
a bond
H
a bond
NH
O
a bond
Q3b
OH


1392
CH
NEt
Q1h
a bond
H
a bond
NH
O
a bond
Q3c
OH


1393
CH
NEt
Q1i
a bond
Me
a bond
NH
S
NH
Q3a
OH


1394
CH
NEt
Q1i
a bond
Me
a bond
NH
S
NH
Q3b
OH


1395
CH
NEt
Q1i
a bond
Me
a bond
NH
S
NH
Q3c
OH


1396
CH
NEt
Q1i
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1397
CH
NEt
Q1i
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1398
CH
NEt
Q1i
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1399
CH
NEt
Q1i
a bond
Me
a bond
NH
O
NH
Q3a
OH


1400
CH
NEt
Q1i
a bond
Me
a bond
NH
O
NH
Q3b
OH


1401
CH
NEt
Q1i
a bond
Me
a bond
NH
O
NH
Q3c
OH


1402
CH
NEt
Q1i
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1403
CH
NEt
Q1i
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1404
CH
NEt
Q1i
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1405
CH
NEt
Q1i
a bond
H
a bond
NH
S
NH
Q3a
OH


1406
CH
NEt
Q1i
a bond
H
a bond
NH
S
NH
Q3b
OH


1407
CH
NEt
Q1i
a bond
H
a bond
NH
S
NH
Q3c
OH


1408
CH
NEt
Q1i
a bond
H
a bond
NH
S
a bond
Q3a
OH


1409
CH
NEt
Q1i
a bond
H
a bond
NH
S
a bond
Q3b
OH


1410
CH
NEt
Q1i
a bond
H
a bond
NH
S
a bond
Q3c
OH


1411
CH
NEt
Q1i
a bond
H
a bond
NH
O
NH
Q3a
OH


1412
CH
NEt
Q1i
a bond
H
a bond
NH
O
NH
Q3b
OH


1413
CH
NEt
Q1i
a bond
H
a bond
NH
O
NH
Q3c
OH


1414
CH
NEt
Q1i
a bond
H
a bond
NH
O
a bond
Q3a
OH


1415
CH
NEt
Q1i
a bond
H
a bond
NH
O
a bond
Q3b
OH


1416
CH
NEt
Q1i
a bond
H
a bond
NH
O
a bond
Q3c
OH


1417
CH
NEt
Q1j
a bond
Me
a bond
NH
S
NH
Q3a
OH


1418
CH
NEt
Q1j
a bond
Me
a bond
NH
S
NH
Q3b
OH


1419
CH
NEt
Q1j
a bond
Me
a bond
NH
S
NH
Q3c
OH


1420
CH
NEt
Q1j
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1421
CH
NEt
Q1j
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1422
CH
NEt
Q1j
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1423
CH
NEt
Q1j
a bond
Me
a bond
NH
O
NH
Q3a
OH


1424
CH
NEt
Q1j
a bond
Me
a bond
NH
O
NH
Q3b
OH


1425
CH
NEt
Q1j
a bond
Me
a bond
NH
O
NH
Q3c
OH


1426
CH
NEt
Q1j
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1427
CH
NEt
Q1j
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1428
CH
NEt
Q1j
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1429
CH
NEt
Q1j
a bond
H
a bond
NH
S
NH
Q3a
OH


1430
CH
NEt
Q1j
a bond
H
a bond
NH
S
NH
Q3b
OH


1431
CH
NEt
Q1j
a bond
H
a bond
NH
S
NH
Q3c
OH


1432
CH
NEt
Q1j
a bond
H
a bond
NH
S
a bond
Q3a
OH


1433
CH
NEt
Q1j
a bond
H
a bond
NH
S
a bond
Q3b
OH


1434
CH
NEt
Q1j
a bond
H
a bond
NH
S
a bond
Q3c
OH


1435
CH
NEt
Q1j
a bond
H
a bond
NH
O
NH
Q3a
OH


1436
CH
NEt
Q1j
a bond
H
a bond
NH
O
NH
Q3b
OH


1437
CH
NEt
Q1j
a bond
H
a bond
NH
O
NH
Q3c
OH


1438
CH
NEt
Q1j
a bond
H
a bond
NH
O
a bond
Q3a
OH


1439
CH
NEt
Q1j
a bond
H
a bond
NH
O
a bond
Q3b
OH


1440
CH
NEt
Q1j
a bond
H
a bond
NH
O
a bond
Q3c
OH


1441
CH
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3a
OH


1442
CH
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3b
OH


1443
CH
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3c
OH


1444
CH
S
Q1a
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1445
CH
S
Q1a
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1446
CH
S
Q1a
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1447
CH
S
Q1a
a bond
Me
a bond
NH
O
NH
Q3a
OH


1448
CH
S
Q1a
a bond
Me
a bond
NH
O
NH
Q3b
OH


1449
CH
S
Q1a
a bond
Me
a bond
NH
O
NH
Q3c
OH


1450
CH
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1451
CH
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1452
CH
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1453
CH
S
Q1a
a bond
H
a bond
NH
S
NH
Q3a
OH


1454
CH
S
Q1a
a bond
H
a bond
NH
S
NH
Q3b
OH


1455
CH
S
Q1a
a bond
H
a bond
NH
S
NH
Q3c
OH


1456
CH
S
Q1a
a bond
H
a bond
NH
S
a bond
Q3a
OH


1457
CH
S
Q1a
a bond
H
a bond
NH
S
a bond
Q3b
OH


1458
CH
S
Q1a
a bond
H
a bond
NH
S
a bond
Q3c
OH


1459
CH
S
Q1a
a bond
H
a bond
NH
O
NH
Q3a
OH


1460
CH
S
Q1a
a bond
H
a bond
NH
O
NH
Q3b
OH


1461
CH
S
Q1a
a bond
H
a bond
NH
O
NH
Q3c
OH


1462
CH
S
Q1a
a bond
H
a bond
NH
O
a bond
Q3a
OH


1463
CH
S
Q1a
a bond
H
a bond
NH
O
a bond
Q3b
OH


1464
CH
S
Q1a
a bond
H
a bond
NH
O
a bond
Q3c
OH


1465
CH
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3a
OH


1466
CH
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3b
OH


1467
CH
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3c
OH


1468
CH
S
Q1b
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1469
CH
S
Q1b
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1470
CH
S
Q1b
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1471
CH
S
Q1b
a bond
Me
a bond
NH
O
NH
Q3a
OH


1472
CH
S
Q1b
a bond
Me
a bond
NH
O
NH
Q3b
OH


1473
CH
S
Q1b
a bond
Me
a bond
NH
O
NH
Q3c
OH


1474
CH
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1475
CH
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1476
CH
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1477
CH
S
Q1b
a bond
H
a bond
NH
S
NH
Q3a
OH


1478
CH
S
Q1b
a bond
H
a bond
NH
S
NH
Q3b
OH


1479
CH
S
Q1b
a bond
H
a bond
NH
S
NH
Q3c
OH


1480
CH
S
Q1b
a bond
H
a bond
NH
S
a bond
Q3a
OH


1481
CH
S
Q1b
a bond
H
a bond
NH
S
a bond
Q3b
OH


1482
CH
S
Q1b
a bond
H
a bond
NH
S
a bond
Q3c
OH


1483
CH
S
Q1b
a bond
H
a bond
NH
O
NH
Q3a
OH


1484
CH
S
Q1b
a bond
H
a bond
NH
O
NH
Q3b
OH


1485
CH
S
Q1b
a bond
H
a bond
NH
O
NH
Q3c
OH


1486
CH
S
Q1b
a bond
H
a bond
NH
O
a bond
Q3a
OH


1487
CH
S
Q1b
a bond
H
a bond
NH
O
a bond
Q3b
OH


1488
CH
S
Q1b
a bond
H
a bond
NH
O
a bond
Q3c
OH


1489
CH
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3a
OH


1490
CH
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3b
OH


1491
CH
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3c
OH


1492
CH
S
Q1c
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1493
CH
S
Q1c
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1494
CH
S
Q1c
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1495
CH
S
Q1c
a bond
Me
a bond
NH
O
NH
Q3a
OH


1496
CH
S
Q1c
a bond
Me
a bond
NH
O
NH
Q3b
OH


1497
CH
S
Q1c
a bond
Me
a bond
NH
O
NH
Q3c
OH


1498
CH
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1499
CH
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1500
CH
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1501
CH
S
Q1c
a bond
H
a bond
NH
S
NH
Q3a
OH


1502
CH
S
Q1c
a bond
H
a bond
NH
S
NH
Q3b
OH


1503
CH
S
Q1c
a bond
H
a bond
NH
S
NH
Q3c
OH


1504
CH
S
Q1c
a bond
H
a bond
NH
S
a bond
Q3a
OH


1505
CH
S
Q1c
a bond
H
a bond
NH
S
a bond
Q3b
OH


1506
CH
S
Q1c
a bond
H
a bond
NH
S
a bond
Q3c
OH


1507
CH
S
Q1c
a bond
H
a bond
NH
O
NH
Q3a
OH


1508
CH
S
Q1c
a bond
H
a bond
NH
O
NH
Q3b
OH


1509
CH
S
Q1c
a bond
H
a bond
NH
O
NH
Q3c
OH


1510
CH
S
Q1c
a bond
H
a bond
NH
O
a bond
Q3a
OH


1511
CH
S
Q1c
a bond
H
a bond
NH
O
a bond
Q3b
OH


1512
CH
S
Q1c
a bond
H
a bond
NH
O
a bond
Q3c
OH


1513
CH
S
Q1d
a bond
Me
a bond
NH
S
NH
Q3a
OH


1514
CH
S
Q1d
a bond
Me
a bond
NH
S
NH
Q3b
OH


1515
CH
S
Q1d
a bond
Me
a bond
NH
S
NH
Q3c
OH


1516
CH
S
Q1d
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1517
CH
S
Q1d
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1518
CH
S
Q1d
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1519
CH
S
Q1d
a bond
Me
a bond
NH
O
NH
Q3a
OH


1520
CH
S
Q1d
a bond
Me
a bond
NH
O
NH
Q3b
OH


1521
CH
S
Q1d
a bond
Me
a bond
NH
O
NH
Q3c
OH


1522
CH
S
Q1d
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1523
CH
S
Q1d
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1524
CH
S
Q1d
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1525
CH
S
Q1d
a bond
H
a bond
NH
S
NH
Q3a
OH


1526
CH
S
Q1d
a bond
H
a bond
NH
S
NH
Q3b
OH


1527
CH
S
Q1d
a bond
H
a bond
NH
S
NH
Q3c
OH


1528
CH
S
Q1d
a bond
H
a bond
NH
S
a bond
Q3a
OH


1529
CH
S
Q1d
a bond
H
a bond
NH
S
a bond
Q3b
OH


1530
CH
S
Q1d
a bond
H
a bond
NH
S
a bond
Q3c
OH


1531
CH
S
Q1d
a bond
H
a bond
NH
O
NH
Q3a
OH


1532
CH
S
Q1d
a bond
H
a bond
NH
O
NH
Q3b
OH


1533
CH
S
Q1d
a bond
H
a bond
NH
O
NH
Q3c
OH


1534
CH
S
Q1d
a bond
H
a bond
NH
O
a bond
Q3a
OH


1535
CH
S
Q1d
a bond
H
a bond
NH
O
a bond
Q3b
OH


1536
CH
S
Q1d
a bond
H
a bond
NH
O
a bond
Q3c
OH


1537
CH
S
Q1e
a bond
Me
a bond
NH
S
NH
Q3a
OH


1538
CH
S
Q1e
a bond
Me
a bond
NH
S
NH
Q3b
OH


1539
CH
S
Q1e
a bond
Me
a bond
NH
S
NH
Q3c
OH


1540
CH
S
Q1e
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1541
CH
S
Q1e
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1542
CH
S
Q1e
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1543
CH
S
Q1e
a bond
Me
a bond
NH
O
NH
Q3a
OH


1544
CH
S
Q1e
a bond
Me
a bond
NH
O
NH
Q3b
OH


1545
CH
S
Q1e
a bond
Me
a bond
NH
O
NH
Q3c
OH


1546
CH
S
Q1e
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1547
CH
S
Q1e
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1548
CH
S
Q1e
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1549
CH
S
Q1e
a bond
H
a bond
NH
S
NH
Q3a
OH


1550
CH
S
Q1e
a bond
H
a bond
NH
S
NH
Q3b
OH


1551
CH
S
Q1e
a bond
H
a bond
NH
S
NH
Q3c
OH


1552
CH
S
Q1e
a bond
H
a bond
NH
S
a bond
Q3a
OH


1553
CH
S
Q1e
a bond
H
a bond
NH
S
a bond
Q3b
OH


1554
CH
S
Q1e
a bond
H
a bond
NH
S
a bond
Q3c
OH


1555
CH
S
Q1e
a bond
H
a bond
NH
O
NH
Q3a
OH


1556
CH
S
Q1e
a bond
H
a bond
NH
O
NH
Q3b
OH


1557
CH
S
Q1e
a bond
H
a bond
NH
O
NH
Q3c
OH


1558
CH
S
Q1e
a bond
H
a bond
NH
O
a bond
Q3a
OH


1559
CH
S
Q1e
a bond
H
a bond
NH
O
a bond
Q3b
OH


1560
CH
S
Q1e
a bond
H
a bond
NH
O
a bond
Q3c
OH


1561
CH
S
Q1f
a bond
Me
a bond
NH
S
NH
Q3a
OH


1562
CH
S
Q1f
a bond
Me
a bond
NH
S
NH
Q3b
OH


1563
CH
S
Q1f
a bond
Me
a bond
NH
S
NH
Q3c
OH


1564
CH
S
Q1f
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1565
CH
S
Q1f
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1566
CH
S
Q1f
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1567
CH
S
Q1f
a bond
Me
a bond
NH
O
NH
Q3a
OH


1568
CH
S
Q1f
a bond
Me
a bond
NH
O
NH
Q3b
OH


1569
CH
S
Q1f
a bond
Me
a bond
NH
O
NH
Q3c
OH


1570
CH
S
Q1f
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1571
CH
S
Q1f
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1572
CH
S
Q1f
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1573
CH
S
Q1f
a bond
H
a bond
NH
S
NH
Q3a
OH


1574
CH
S
Q1f
a bond
H
a bond
NH
S
NH
Q3b
OH


1575
CH
S
Q1f
a bond
H
a bond
NH
S
NH
Q3c
OH


1576
CH
S
Q1f
a bond
H
a bond
NH
S
a bond
Q3a
OH


1577
CH
S
Q1f
a bond
H
a bond
NH
S
a bond
Q3b
OH


1578
CH
S
Q1f
a bond
H
a bond
NH
S
a bond
Q3c
OH


1579
CH
S
Q1f
a bond
H
a bond
NH
O
NH
Q3a
OH


1580
CH
S
Q1f
a bond
H
a bond
NH
O
NH
Q3b
OH


1581
CH
S
Q1f
a bond
H
a bond
NH
O
NH
Q3c
OH


1582
CH
S
Q1f
a bond
H
a bond
NH
O
a bond
Q3a
OH


1583
CH
S
Q1f
a bond
H
a bond
NH
O
a bond
Q3b
OH


1584
CH
S
Q1f
a bond
H
a bond
NH
O
a bond
Q3c
OH


1585
CH
S
Q1g
a bond
Me
a bond
NH
S
NH
Q3a
OH


1586
CH
S
Q1g
a bond
Me
a bond
NH
S
NH
Q3b
OH


1587
CH
S
Q1g
a bond
Me
a bond
NH
S
NH
Q3c
OH


1588
CH
S
Q1g
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1589
CH
S
Q1g
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1590
CH
S
Q1g
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1591
CH
S
Q1g
a bond
Me
a bond
NH
O
NH
Q3a
OH


1592
CH
S
Q1g
a bond
Me
a bond
NH
O
NH
Q3b
OH


1593
CH
S
Q1g
a bond
Me
a bond
NH
O
NH
Q3c
OH


1594
CH
S
Q1g
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1595
CH
S
Q1g
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1596
CH
S
Q1g
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1597
CH
S
Q1g
a bond
H
a bond
NH
S
NH
Q3a
OH


1598
CH
S
Q1g
a bond
H
a bond
NH
S
NH
Q3b
OH


1599
CH
S
Q1g
a bond
H
a bond
NH
S
NH
Q3c
OH


1600
CH
S
Q1g
a bond
H
a bond
NH
S
a bond
Q3a
OH


1601
CH
S
Q1g
a bond
H
a bond
NH
S
a bond
Q3b
OH


1602
CH
S
Q1g
a bond
H
a bond
NH
S
a bond
Q3c
OH


1603
CH
S
Q1g
a bond
H
a bond
NH
O
NH
Q3a
OH


1604
CH
S
Q1g
a bond
H
a bond
NH
O
NH
Q3b
OH


1605
CH
S
Q1g
a bond
H
a bond
NH
O
NH
Q3c
OH


1606
CH
S
Q1g
a bond
H
a bond
NH
O
a bond
Q3a
OH


1607
CH
S
Q1g
a bond
H
a bond
NH
O
a bond
Q3b
OH


1608
CH
S
Q1g
a bond
H
a bond
Nh
O
a bond
Q3c
OH


1609
CH
S
Q1h
a bond
Me
a bond
NH
S
NH
Q3a
OH


1610
CH
S
Q1h
a bond
Me
a bond
NH
S
NH
Q3b
OH


1611
CH
S
Q1h
a bond
Me
a bond
NH
S
NH
Q3c
OH


1612
CH
S
Q1h
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1613
CH
S
Q1h
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1614
CH
S
Q1h
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1615
CH
S
Q1h
a bond
Me
a bond
NH
O
NH
Q3a
OH


1616
CH
S
Q1h
a bond
Me
a bond
NH
O
NH
Q3b
OH


1617
CH
S
Q1h
a bond
Me
a bond
NH
O
NH
Q3c
OH


1618
CH
S
Q1h
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1619
CH
S
Q1h
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1620
CH
S
Q1h
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1621
CH
S
Q1h
a bond
H
a bond
NH
S
NH
Q3a
OH


1622
CH
S
Q1h
a bond
H
a bond
NH
S
NH
Q3b
OH


1623
CH
S
Q1h
a bond
H
a bond
NH
S
NH
Q3c
OH


1624
CH
S
Q1h
a bond
H
a bond
NH
S
a bond
Q3a
OH


1625
CH
S
Q1h
a bond
H
a bond
NH
S
a bond
Q3b
OH


1626
CH
S
Q1h
a bond
H
a bond
NH
S
a bond
Q3c
OH


1627
CH
S
Q1h
a bond
H
a bond
NH
O
NH
Q3a
OH


1628
CH
S
Q1h
a bond
H
a bond
NH
O
NH
Q3b
OH


1629
CH
S
Q1h
a bond
H
a bond
NH
O
NH
Q3c
OH


1630
CH
S
Q1h
a bond
H
a bond
NH
O
a bond
Q3a
OH


1631
CH
S
Q1h
a bond
H
a bond
NH
O
a bond
Q3b
OH


1632
CH
S
Q1h
a bond
H
a bond
NH
O
a bond
Q3c
OH


1633
CH
S
Q1i
a bond
Me
a bond
NH
S
NH
Q3a
OH


1634
CH
S
Q1i
a bond
Me
a bond
NH
S
NH
Q3b
OH


1635
CH
S
Q1i
a bond
Me
a bond
NH
S
NH
Q3c
OH


1636
CH
S
Q1i
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1637
CH
S
Q1i
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1638
CH
S
Q1i
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1639
CH
S
Q1i
a bond
Me
a bond
NH
O
NH
Q3a
OH


1640
CH
S
Q1i
a bond
Me
a bond
NH
O
NH
Q3b
OH


1641
CH
S
Q1i
a bond
Me
a bond
NH
O
NH
Q3c
OH


1642
CH
S
Q1i
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1643
CH
S
Q1i
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1644
CH
S
Q1i
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1645
CH
S
Q1i
a bond
H
a bond
NH
S
NH
Q3a
OH


1646
CH
S
Q1i
a bond
H
a bond
NH
S
NH
Q3b
OH


1647
CH
S
Q1i
a bond
H
a bond
NH
S
NH
Q3c
OH


1648
CH
S
Q1i
a bond
H
a bond
NH
S
a bond
Q3a
OH


1649
CH
S
Q1i
a bond
H
a bond
NH
S
a bond
Q3b
OH


1650
CH
S
Q1i
a bond
H
a bond
NH
S
a bond
Q3c
OH


1651
CH
S
Q1i
a bond
H
a bond
NH
O
NH
Q3a
OH


1652
CH
S
Q1i
a bond
H
a bond
NH
O
NH
Q3b
OH


1653
CH
S
Q1i
a bond
H
a bond
NH
O
NH
Q3c
OH


1654
CH
S
Q1i
a bond
H
a bond
NH
O
a bond
Q3a
OH


1655
CH
S
Q1i
a bond
H
a bond
NH
O
a bond
Q3b
OH


1656
CH
S
Q1i
a bond
H
a bond
NH
O
a bond
Q3c
OH


1657
CH
S
Q1j
a bond
Me
a bond
NH
S
NH
Q3a
OH


1658
CH
S
Q1j
a bond
Me
a bond
NH
S
NH
Q3b
OH


1659
CH
S
Q1j
a bond
Me
a bond
NH
S
NH
Q3c
OH


1660
CH
S
Q1j
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1661
CH
S
Q1j
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1662
CH
S
Q1j
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1663
CH
S
Q1j
a bond
Me
a bond
NH
O
NH
Q3a
OH


1664
CH
S
Q1j
a bond
Me
a bond
NH
O
NH
Q3b
OH


1665
CH
S
Q1j
a bond
Me
a bond
NH
O
NH
Q3c
OH


1666
CH
S
Q1j
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1667
CH
S
Q1j
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1668
CH
S
Q1j
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1669
CH
S
Q1j
a bond
H
a bond
NH
S
NH
Q3a
OH


1670
CH
S
Q1j
a bond
H
a bond
NH
S
NH
Q3b
OH


1671
CH
S
Q1j
a bond
H
a bond
NH
S
NH
Q3c
OH


1672
CH
S
Q1j
a bond
H
a bond
NH
S
a bond
Q3a
OH


1673
CH
S
Q1j
a bond
H
a bond
NH
S
a bond
Q3b
OH


1674
CH
S
Q1j
a bond
H
a bond
NH
S
a bond
Q3c
OH


1675
CH
S
Q1j
a bond
H
a bond
NH
O
NH
Q3a
OH


1676
CH
S
Q1j
a bond
H
a bond
NH
O
NH
Q3b
OH


1677
CH
S
Q1j
a bond
H
a bond
NH
O
NH
Q3c
OH


1678
CH
S
Q1j
a bond
H
a bond
NH
O
a bond
Q3a
OH


1679
CH
S
Q1j
a bond
H
a bond
NH
O
a bond
Q3b
OH


1680
CH
S
Q1j
a bond
H
a bond
NH
O
a bond
Q3c
OH


1681
CH
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3a
OH


1682
CH
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3b
OH


1683
CH
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3c
OH


1684
CH
O
Q1a
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1685
CH
O
Q1a
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1686
CH
O
Q1a
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1687
CH
O
Q1a
a bond
Me
a bond
NH
O
NH
Q3a
OH


1688
CH
O
Q1a
a bond
Me
a bond
NH
O
NH
Q3b
OH


1689
CH
O
Q1a
a bond
Me
a bond
NH
O
NH
Q3c
OH


1690
CH
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1691
CH
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1692
CH
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1693
CH
O
Q1a
a bond
H
a bond
NH
S
NH
Q3a
OH


1694
CH
O
Q1a
a bond
H
a bond
NH
S
NH
Q3b
OH


1695
CH
O
Q1a
a bond
H
a bond
NH
S
NH
Q3c
OH


1696
CH
O
Q1a
a bond
H
a bond
NH
S
a bond
Q3a
OH


1697
CH
O
Q1a
a bond
H
a bond
NH
S
a bond
Q3b
OH


1698
CH
O
Q1a
a bond
H
a bond
NH
S
a bond
Q3c
OH


1699
CH
O
Q1a
a bond
H
a bond
NH
O
NH
Q3a
OH


1700
CH
O
Q1a
a bond
H
a bond
NH
O
NH
Q3b
OH


1701
CH
O
Q1a
a bond
H
a bond
NH
O
NH
Q3c
OH


1702
CH
O
Q1a
a bond
H
a bond
NH
O
a bond
Q3a
OH


1703
CH
O
Q1a
a bond
H
a bond
NH
O
a bond
Q3b
OH


1704
CH
O
Q1a
a bond
H
a bond
NH
O
a bond
Q3c
OH


1705
CH
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3a
OH


1706
CH
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3b
OH


1707
CH
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3c
OH


1708
CH
O
Q1b
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1709
CH
O
Q1b
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1710
CH
O
Q1b
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1711
CH
O
Q1b
a bond
Me
a bond
NH
O
NH
Q3a
OH


1712
CH
O
Q1b
a bond
Me
a bond
NH
O
NH
Q3b
OH


1713
CH
O
Q1b
a bond
Me
a bond
NH
O
NH
Q3c
OH


1714
CH
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1715
CH
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1716
CH
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1717
CH
O
Q1b
a bond
H
a bond
NH
S
NH
Q3a
OH


1718
CH
O
Q1b
a bond
H
a bond
NH
S
NH
Q3b
OH


1719
CH
O
Q1b
a bond
H
a bond
NH
S
NH
Q3c
OH


1720
CH
O
Q1b
a bond
H
a bond
NH
S
a bond
Q3a
OH


1721
CH
O
Q1b
a bond
H
a bond
NH
S
a bond
Q3b
OH


1722
CH
O
Q1b
a bond
H
a bond
NH
S
a bond
Q3c
OH


1723
CH
O
Q1b
a bond
H
a bond
NH
O
NH
Q3a
OH


1724
CH
O
Q1b
a bond
H
a bond
NH
O
NH
Q3b
OH


1725
CH
O
Q1b
a bond
H
a bond
NH
O
NH
Q3c
OH


1726
CH
O
Q1b
a bond
H
a bond
NH
O
a bond
Q3a
OH


1727
CH
O
Q1b
a bond
H
a bond
NH
O
a bond
Q3b
OH


1728
CH
O
Q1b
a bond
H
a bond
NH
O
a bond
Q3c
OH


1729
CH
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3a
OH


1730
CH
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3b
OH


1731
CH
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3c
OH


1732
CH
O
Q1c
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1733
CH
O
Q1c
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1734
CH
O
Q1c
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1735
CH
O
Q1c
a bond
Me
a bond
NH
O
NH
Q3a
OH


1736
CH
O
Q1c
a bond
Me
a bond
NH
O
NH
Q3b
OH


1737
CH
O
Q1c
a bond
Me
a bond
NH
O
NH
Q3c
OH


1738
CH
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1739
CH
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1740
CH
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1741
CH
O
Q1c
a bond
H
a bond
NH
S
NH
Q3a
OH


1742
CH
O
Q1c
a bond
H
a bond
NH
S
NH
Q3b
OH


1743
CH
O
Q1c
a bond
H
a bond
NH
S
NH
Q3c
OH


1744
CH
O
Q1c
a bond
H
a bond
NH
S
a bond
Q3a
OH


1745
CH
O
Q1c
a bond
H
a bond
NH
S
a bond
Q3b
OH


1746
CH
O
Q1c
a bond
H
a bond
NH
S
a bond
Q3c
OH


1747
CH
O
Q1c
a bond
H
a bond
NH
O
NH
Q3a
OH


1748
CH
O
Q1c
a bond
H
a bond
NH
O
NH
Q3b
OH


1749
CH
O
Q1c
a bond
H
a bond
NH
O
NH
Q3c
OH


1750
CH
O
Q1c
a bond
H
a bond
NH
O
a bond
Q3a
OH


1751
CH
O
Q1c
a bond
H
a bond
NH
O
a bond
Q3b
OH


1752
CH
O
Q1c
a bond
H
a bond
NH
O
a bond
Q3c
OH


1753
CH
O
Q1d
a bond
Me
a bond
NH
S
NH
Q3a
OH


1754
CH
O
Q1d
a bond
Me
a bond
NH
S
NH
Q3b
OH


1755
CH
O
Q1d
a bond
Me
a bond
NH
S
NH
Q3c
OH


1756
CH
O
Q1d
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1757
CH
O
Q1d
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1758
CH
O
Q1d
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1759
CH
O
Q1d
a bond
Me
a bond
NH
O
NH
Q3a
OH


1760
CH
O
Q1d
a bond
Me
a bond
NH
O
NH
Q3b
OH


1761
CH
O
Q1d
a bond
Me
a bond
NH
O
NH
Q3c
OH


1762
CH
O
Q1d
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1763
CH
O
Q1d
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1764
CH
O
Q1d
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1765
CH
O
Q1d
a bond
H
a bond
NH
S
NH
Q3a
OH


1766
CH
O
Q1d
a bond
H
a bond
NH
S
NH
Q3b
OH


1767
CH
O
Q1d
a bond
H
a bond
NH
S
NH
Q3c
OH


1768
CH
O
Q1d
a bond
H
a bond
NH
S
a bond
Q3a
OH


1769
CH
O
Q1d
a bond
H
a bond
NH
S
a bond
Q3b
OH


1770
CH
O
Q1d
a bond
H
a bond
NH
S
a bond
Q3c
OH


1771
CH
O
Q1d
a bond
H
a bond
NH
O
NH
Q3a
OH


1772
CH
O
Q1d
a bond
H
a bond
NH
O
NH
Q3b
OH


1773
CH
O
Q1d
a bond
H
a bond
NH
O
NH
Q3c
OH


1774
CH
O
Q1d
a bond
H
a bond
NH
O
a bond
Q3a
OH


1775
CH
O
Q1d
a bond
H
a bond
NH
O
a bond
Q3b
OH


1776
CH
O
Q1d
a bond
H
a bond
NH
O
a bond
Q3c
OH


1777
CH
O
Q1e
a bond
Me
a bond
NH
S
NH
Q3a
OH


1778
CH
O
Q1e
a bond
Me
a bond
NH
S
NH
Q3b
OH


1779
CH
O
Q1e
a bond
Me
a bond
NH
S
NH
Q3c
OH


1780
CH
O
Q1e
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1781
CH
O
Q1e
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1782
CH
O
Q1e
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1783
CH
O
Q1e
a bond
Me
a bond
NH
O
NH
Q3a
OH


1784
CH
O
Q1e
a bond
Me
a bond
NH
O
NH
Q3b
OH


1785
CH
O
Q1e
a bond
Me
a bond
NH
O
NH
Q3c
OH


1786
CH
O
Q1e
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1787
CH
O
Q1e
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1788
CH
O
Q1e
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1789
CH
O
Q1e
a bond
H
a bond
NH
S
NH
Q3a
OH


1790
CH
O
Q1e
a bond
H
a bond
NH
S
NH
Q3b
OH


1791
CH
O
Q1e
a bond
H
a bond
NH
S
NH
Q3c
OH


1792
CH
O
Q1e
a bond
H
a bond
NH
S
a bond
Q3a
OH


1793
CH
O
Q1e
a bond
H
a bond
NH
S
a bond
Q3b
OH


1794
CH
O
Q1e
a bond
H
a bond
NH
S
a bond
Q3c
OH


1795
CH
O
Q1e
a bond
H
a bond
NH
O
NH
Q3a
OH


1796
CH
O
Q1e
a bond
H
a bond
NH
O
NH
Q3b
OH


1797
CH
O
Q1e
a bond
H
a bond
NH
O
NH
Q3c
OH


1798
CH
O
Q1e
a bond
H
a bond
NH
O
a bond
Q3a
OH


1799
CH
O
Q1e
a bond
H
a bond
NH
O
a bond
Q3b
OH


1800
CH
O
Q1e
a bond
H
a bond
NH
O
a bond
Q3c
OH


1801
CH
O
Q1f
a bond
Me
a bond
NH
S
NH
Q3a
OH


1802
CH
O
Q1f
a bond
Me
a bond
NH
S
NH
Q3b
OH


1803
CH
O
Q1f
a bond
Me
a bond
NH
S
NH
Q3c
OH


1804
CH
O
Q1f
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1805
CH
O
Q1f
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1806
CH
O
Q1f
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1807
CH
O
Q1f
a bond
Me
a bond
NH
O
NH
Q3a
OH


1808
CH
O
Q1f
a bond
Me
a bond
NH
O
NH
Q3b
OH


1809
CH
O
Q1f
a bond
Me
a bond
NH
O
NH
Q3c
OH


1810
CH
O
Q1f
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1811
CH
O
Q1f
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1812
CH
O
Q1f
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1813
CH
O
Q1f
a bond
H
a bond
NH
S
NH
Q3a
OH


1814
CH
O
Q1f
a bond
H
a bond
NH
S
NH
Q3b
OH


1815
CH
O
Q1f
a bond
H
a bond
NH
S
NH
Q3c
OH


1816
CH
O
Q1f
a bond
H
a bond
NH
S
a bond
Q3a
OH


1817
CH
O
Q1f
a bond
H
a bond
NH
S
a bond
Q3b
OH


1818
CH
O
Q1f
a bond
H
a bond
NH
S
a bond
Q3c
OH


1819
CH
O
Q1f
a bond
H
a bond
NH
O
NH
Q3a
OH


1820
CH
O
Q1f
a bond
H
a bond
NH
O
NH
Q3b
OH


1821
CH
O
Q1f
a bond
H
a bond
NH
O
NH
Q3c
OH


1822
CH
O
Q1f
a bond
H
a bond
NH
O
a bond
Q3a
OH


1823
CH
O
Q1f
a bond
H
a bond
NH
O
a bond
Q3b
OH


1824
CH
O
Q1f
a bond
H
a bond
NH
O
a bond
Q3c
OH


1825
CH
O
Q1g
a bond
Me
a bond
NH
S
NH
Q3a
OH


1826
CH
O
Q1g
a bond
Me
a bond
NH
S
NH
Q3b
OH


1827
CH
O
Q1g
a bond
Me
a bond
NH
S
NH
Q3c
OH


1828
CH
O
Q1g
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1829
CH
O
Q1g
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1830
CH
O
Q1g
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1831
CH
O
Q1g
a bond
Me
a bond
NH
O
NH
Q3a
OH


1832
CH
O
Q1g
a bond
Me
a bond
NH
O
NH
Q3b
OH


1833
CH
O
Q1g
a bond
Me
a bond
NH
O
NH
Q3c
OH


1834
CH
O
Q1g
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1835
CH
O
Q1g
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1836
CH
O
Q1g
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1837
CH
O
Q1g
a bond
H
a bond
NH
S
NH
Q3a
OH


1838
CH
O
Q1g
a bond
H
a bond
NH
S
NH
Q3b
OH


1839
CH
O
Q1g
a bond
H
a bond
NH
S
NH
Q3c
OH


1840
CH
O
Q1g
a bond
H
a bond
NH
S
a bond
Q3a
OH


1841
CH
O
Q1g
a bond
H
a bond
NH
S
a bond
Q3b
OH


1842
CH
O
Q1g
a bond
H
a bond
NH
S
a bond
Q3c
OH


1843
CH
O
Q1g
a bond
H
a bond
NH
O
NH
Q3a
OH


1844
CH
O
Q1g
a bond
H
a bond
NH
O
NH
Q3b
OH


1845
CH
O
Q1g
a bond
H
a bond
NH
O
NH
Q3c
OH


1846
CH
O
Q1g
a bond
H
a bond
NH
O
a bond
Q3a
OH


1847
CH
O
Q1g
a bond
H
a bond
NH
O
a bond
Q3b
OH


1848
CH
O
Q1g
a bond
H
a bond
NH
O
a bond
Q3c
OH


1849
CH
O
Q1h
a bond
Me
a bond
NH
S
NH
Q3a
OH


1850
CH
O
Q1h
a bond
Me
a bond
NH
S
NH
Q3b
OH


1851
CH
O
Q1h
a bond
Me
a bond
NH
S
NH
Q3c
OH


1852
CH
O
Q1h
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1853
CH
O
Q1h
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1854
CH
O
Q1h
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1855
CH
O
Q1h
a bond
Me
a bond
NH
O
NH
Q3a
OH


1856
CH
O
Q1h
a bond
Me
a bond
NH
O
NH
Q3b
OH


1857
CH
O
Q1h
a bond
Me
a bond
NH
O
NH
Q3c
OH


1858
CH
O
Q1h
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1859
CH
O
Q1h
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1860
CH
O
Q1h
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1861
CH
O
Q1h
a bond
H
a bond
NH
S
NH
Q3a
OH


1862
CH
O
Q1h
a bond
H
a bond
NH
S
NH
Q3b
OH


1863
CH
O
Q1h
a bond
H
a bond
NH
S
NH
Q3c
OH


1864
CH
O
Q1h
a bond
H
a bond
NH
S
a bond
Q3a
OH


1865
CH
O
Q1h
a bond
H
a bond
NH
S
a bond
Q3b
OH


1866
CH
O
Q1h
a bond
H
a bond
NH
S
a bond
Q3c
OH


1867
CH
O
Q1h
a bond
H
a bond
NH
O
NH
Q3a
OH


1868
CH
O
Q1h
a bond
H
a bond
NH
O
NH
Q3b
OH


1869
CH
O
Q1h
a bond
H
a bond
NH
O
NH
Q3c
OH


1870
CH
O
Q1h
a bond
H
a bond
NH
O
a bond
Q3a
OH


1871
CH
O
Q1h
a bond
H
a bond
NH
O
a bond
Q3b
OH


1872
CH
O
Q1h
a bond
H
a bond
NH
O
a bond
Q3c
OH


1873
CH
O
Q1i
a bond
Me
a bond
NH
S
NH
Q3a
OH


1874
CH
O
Q1i
a bond
Me
a bond
NH
S
NH
Q3b
OH


1875
CH
O
Q1i
a bond
Me
a bond
NH
S
NH
Q3c
OH


1876
CH
O
Q1i
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1877
CH
O
Q1i
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1878
CH
O
Q1i
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1879
CH
O
Q1i
a bond
Me
a bond
NH
O
NH
Q3a
OH


1880
CH
O
Q1i
a bond
Me
a bond
NH
O
NH
Q3b
OH


1881
CH
O
Q1i
a bond
Me
a bond
NH
O
NH
Q3c
OH


1882
CH
O
Q1i
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1883
CH
O
Q1i
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1884
CH
O
Q1i
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1885
CH
O
Q1i
a bond
H
a bond
NH
S
NH
Q3a
OH


1886
CH
O
Q1i
a bond
H
a bond
NH
S
NH
Q3b
OH


1887
CH
O
Q1i
a bond
H
a bond
NH
S
NH
Q3c
OH


1888
CH
O
Q1i
a bond
H
a bond
NH
S
a bond
Q3a
OH


1889
CH
O
Q1i
a bond
H
a bond
NH
S
a bond
Q3b
OH


1890
CH
O
Q1i
a bond
H
a bond
NH
S
a bond
Q3c
OH


1891
CH
O
Q1i
a bond
H
a bond
NH
O
NH
Q3a
OH


1892
CH
O
Q1i
a bond
H
a bond
NH
O
NH
Q3b
OH


1893
CH
O
Q1i
a bond
H
a bond
NH
O
NH
Q3c
OH


1894
CH
O
Q1i
a bond
H
a bond
NH
O
a bond
Q3a
OH


1895
CH
O
Q1i
a bond
H
a bond
NH
O
a bond
Q3b
OH


1896
CH
O
Q1i
a bond
H
a bond
NH
O
a bond
Q3c
OH


1897
CH
O
Q1j
a bond
Me
a bond
NH
S
NH
Q3a
OH


1898
CH
O
Q1j
a bond
Me
a bond
NH
S
NH
Q3b
OH


1899
CH
O
Q1j
a bond
Me
a bond
NH
S
NH
Q3c
OH


1900
CH
O
Q1j
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1901
CH
O
Q1j
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1902
CH
O
Q1j
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1903
CH
O
Q1j
a bond
Me
a bond
NH
O
NH
Q3a
OH


1904
CH
O
Q1j
a bond
Me
a bond
NH
O
NH
Q3b
OH


1905
CH
O
Q1j
a bond
Me
a bond
NH
O
NH
Q3c
OH


1906
CH
O
Q1j
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1907
CH
O
Q1j
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1908
CH
O
Q1j
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1909
CH
O
Q1j
a bond
H
a bond
NH
S
NH
Q3a
OH


1910
CH
O
Q1j
a bond
H
a bond
NH
S
NH
Q3b
OH


1911
CH
O
Q1j
a bond
H
a bond
NH
S
NH
Q3c
OH


1912
CH
O
Q1j
a bond
H
a bond
NH
S
a bond
Q3a
OH


1913
CH
O
Q1j
a bond
H
a bond
NH
S
a bond
Q3b
OH


1914
CH
O
Q1j
a bond
H
a bond
NH
S
a bond
Q3c
OH


1915
CH
O
Q1j
a bond
H
a bond
NH
O
NH
Q3a
OH


1916
CH
O
Q1j
a bond
H
a bond
NH
O
NH
Q3b
OH


1917
CH
O
Q1j
a bond
H
a bond
NH
O
NH
Q3c
OH


1918
CH
O
Q1j
a bond
H
a bond
NH
O
a bond
Q3a
OH


1919
CH
O
Q1j
a bond
H
a bond
NH
O
a bond
Q3b
OH


1920
CH
O
Q1j
a bond
H
a bond
NH
O
a bond
Q3c
OH


1921
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3a
OH


1922
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3b
OH


1923
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3c
OH


1924
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1925
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1926
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1927
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
NH
Q3a
OH


1928
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
NH
Q3b
OH


1929
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
NH
Q3c
OH


1930
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1931
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1932
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1933
CMe
NMe
Q1a
a bond
H
a bond
NH
S
NH
Q3a
OH


1934
CMe
NMe
Q1a
a bond
H
a bond
NH
S
NH
Q3b
OH


1935
CMe
NMe
Q1a
a bond
H
a bond
NH
S
NH
Q3c
OH


1936
CMe
NMe
Q1a
a bond
H
a bond
NH
S
a bond
Q3a
OH


1937
CMe
NMe
Q1a
a bond
H
a bond
NH
S
a bond
Q3b
OH


1938
CMe
NMe
Q1a
a bond
H
a bond
NH
S
a bond
Q3c
OH


1939
CMe
NMe
Q1a
a bond
H
a bond
NH
O
NH
Q3a
OH


1940
CMe
NMe
Q1a
a bond
H
a bond
NH
O
NH
Q3b
OH


1941
CMe
NMe
Q1a
a bond
H
a bond
NH
O
NH
Q3c
OH


1942
CMe
NMe
Q1a
a bond
H
a bond
NH
O
a bond
Q3a
OH


1943
CMe
NMe
Q1a
a bond
H
a bond
NH
O
a bond
Q3b
OH


1944
CMe
NMe
Q1a
a bond
H
a bond
NH
O
a bond
Q3c
OH


1945
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3a
OH


1946
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3b
OH


1947
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3c
OH


1948
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1949
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1950
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1951
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
NH
Q3a
OH


1952
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
NH
Q3b
OH


1953
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
NH
Q3c
OH


1954
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1955
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1956
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1957
CMe
NMe
Q1b
a bond
H
a bond
NH
S
NH
Q3a
OH


1958
CMe
NMe
Q1b
a bond
H
a bond
NH
S
NH
Q3b
OH


1959
CMe
NMe
Q1b
a bond
H
a bond
NH
S
NH
Q3c
OH


1960
CMe
NMe
Q1b
a bond
H
a bond
NH
S
a bond
Q3a
OH


1961
CMe
NMe
Q1b
a bond
H
a bond
NH
S
a bond
Q3b
OH


1962
CMe
NMe
Q1b
a bond
H
a bond
NH
S
a bond
Q3c
OH


1963
CMe
NMe
Q1b
a bond
H
a bond
NH
O
NH
Q3a
OH


1964
CMe
NMe
Q1b
a bond
H
a bond
NH
O
NH
Q3b
OH


1965
CMe
NMe
Q1b
a bond
H
a bond
NH
O
NH
Q3c
OH


1966
CMe
NMe
Q1b
a bond
H
a bond
NH
O
a bond
Q3a
OH


1967
CMe
NMe
Q1b
a bond
H
a bond
NH
O
a bond
Q3b
OH


1968
CMe
NMe
Q1b
a bond
H
a bond
NH
O
a bond
Q3c
OH


1969
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3a
OH


1970
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3b
OH


1971
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3c
OH


1972
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1973
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1974
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1975
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
NH
Q3a
OH


1976
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
NH
Q3b
OH


1977
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
NH
Q3c
OH


1978
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1979
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1980
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1981
CMe
NMe
Q1c
a bond
H
a bond
NH
S
NH
Q3a
OH


1982
CMe
NMe
Q1c
a bond
H
a bond
NH
S
NH
Q3b
OH


1983
CMe
NMe
Q1c
a bond
H
a bond
NH
S
NH
Q3c
OH


1984
CMe
NMe
Q1c
a bond
H
a bond
NH
S
a bond
Q3a
OH


1985
CMe
NMe
Q1c
a bond
H
a bond
NH
S
a bond
Q3b
OH


1986
CMe
NMe
Q1c
a bond
H
a bond
NH
S
a bond
Q3c
OH


1987
CMe
NMe
Q1c
a bond
H
a bond
NH
O
NH
Q3a
OH


1988
CMe
NMe
Q1c
a bond
H
a bond
NH
O
NH
Q3b
OH


1989
CMe
NMe
Q1c
a bond
H
a bond
NH
O
NH
Q3c
OH


1990
CMe
NMe
Q1c
a bond
H
a bond
NH
O
a bond
Q3a
OH


1991
CMe
NMe
Q1c
a bond
H
a bond
NH
O
a bond
Q3b
OH


1992
CMe
NMe
Q1c
a bond
H
a bond
NH
O
a bond
Q3c
OH


1993
CMe
NMe
Q1d
a bond
Me
a bond
NH
S
NH
Q3a
OH


1994
CMe
NMe
Q1d
a bond
Me
a bond
NH
S
NH
Q3b
OH


1995
CMe
NMe
Q1d
a bond
Me
a bond
NH
S
NH
Q3c
OH


1996
CMe
NMe
Q1d
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1997
CMe
NMe
Q1d
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1998
CMe
NMe
Q1d
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1999
CMe
NMe
Q1d
a bond
Me
a bond
NH
O
NH
Q3a
OH


2000
CMe
NMe
Q1d
a bond
Me
a bond
NH
O
NH
Q3b
OH


2001
CMe
NMe
Q1d
a bond
Me
a bond
NH
O
NH
Q3c
OH


2002
CMe
NMe
Q1d
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2003
CMe
NMe
Q1d
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2004
CMe
NMe
Q1d
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2005
CMe
NMe
Q1d
a bond
H
a bond
NH
S
NH
Q3a
OH


2006
CMe
NMe
Q1d
a bond
H
a bond
NH
S
NH
Q3b
OH


2007
CMe
NMe
Q1d
a bond
H
a bond
NH
S
NH
Q3c
OH


2008
CMe
NMe
Q1d
a bond
H
a bond
NH
S
a bond
Q3a
OH


2009
CMe
NMe
Q1d
a bond
H
a bond
NH
S
a bond
Q3b
OH


2010
CMe
NMe
Q1d
a bond
H
a bond
NH
S
a bond
Q3c
OH


2011
CMe
NMe
Q1d
a bond
H
a bond
NH
O
NH
Q3a
OH


2012
CMe
NMe
Q1d
a bond
H
a bond
NH
O
NH
Q3b
OH


2013
CMe
NMe
Q1d
a bond
H
a bond
NH
O
NH
Q3c
OH


2014
CMe
NMe
Q1d
a bond
H
a bond
NH
O
a bond
Q3a
OH


2015
CMe
NMe
Q1d
a bond
H
a bond
NH
O
a bond
Q3b
OH


2016
CMe
NMe
Q1d
a bond
H
a bond
NH
O
a bond
Q3c
OH


2017
CMe
NMe
Q1e
a bond
Me
a bond
NH
S
NH
Q3a
OH


2018
CMe
NMe
Q1e
a bond
Me
a bond
NH
S
NH
Q3b
OH


2019
CMe
NMe
Q1e
a bond
Me
a bond
NH
S
NH
Q3c
OH


2020
CMe
NMe
Q1e
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2021
CMe
NMe
Q1e
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2022
CMe
NMe
Q1e
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2023
CMe
NMe
Q1e
a bond
Me
a bond
NH
O
NH
Q3a
OH


2024
CMe
NMe
Q1e
a bond
Me
a bond
NH
O
NH
Q3b
OH


2025
CMe
NMe
Q1e
a bond
Me
a bond
NH
O
NH
Q3c
OH


2026
CMe
NMe
Q1e
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2027
CMe
NMe
Q1e
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2028
CMe
NMe
Q1e
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2029
CMe
NMe
Q1e
a bond
H
a bond
NH
S
NH
Q3a
OH


2030
CMe
NMe
Q1e
a bond
H
a bond
NH
S
NH
Q3b
OH


2031
CMe
NMe
Q1e
a bond
H
a bond
NH
S
NH
Q3c
OH


2032
CMe
NMe
Q1e
a bond
H
a bond
NH
S
a bond
Q3a
OH


2033
CMe
NMe
Q1e
a bond
H
a bond
NH
S
a bond
Q3b
OH


2034
CMe
NMe
Q1e
a bond
H
a bond
NH
S
a bond
Q3c
OH


2035
CMe
NMe
Q1e
a bond
H
a bond
NH
O
NH
Q3a
OH


2036
CMe
NMe
Q1e
a bond
H
a bond
NH
O
NH
Q3b
OH


2037
CMe
NMe
Q1e
a bond
H
a bond
NH
O
NH
Q3c
OH


2038
CMe
NMe
Q1e
a bond
H
a bond
NH
O
a bond
Q3a
OH


2039
CMe
NMe
Q1e
a bond
H
a bond
NH
O
a bond
Q3b
OH


2040
CMe
NMe
Q1e
a bond
H
a bond
NH
O
a bond
Q3c
OH


2041
CMe
NMe
Q1f
a bond
Me
a bond
NH
S
NH
Q3a
OH


2042
CMe
NMe
Q1f
a bond
Me
a bond
NH
S
NH
Q3b
OH


2043
CMe
NMe
Q1f
a bond
Me
a bond
NH
S
NH
Q3c
OH


2044
CMe
NMe
Q1f
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2045
CMe
NMe
Q1f
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2046
CMe
NMe
Q1f
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2047
CMe
NMe
Q1f
a bond
Me
a bond
NH
O
NH
Q3a
OH


2048
CMe
NMe
Q1f
a bond
Me
a bond
NH
O
NH
Q3b
OH


2049
CMe
NMe
Q1f
a bond
Me
a bond
NH
O
NH
Q3c
OH


2050
CMe
NMe
Q1f
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2051
CMe
NMe
Q1f
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2052
CMe
NMe
Q1f
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2053
CMe
NMe
Q1f
a bond
H
a bond
NH
S
NH
Q3a
OH


2054
CMe
NMe
Q1f
a bond
H
a bond
NH
S
NH
Q3b
OH


2055
CMe
NMe
Q1f
a bond
H
a bond
NH
S
NH
Q3c
OH


2056
CMe
NMe
Q1f
a bond
H
a bond
NH
S
a bond
Q3a
OH


2057
CMe
NMe
Q1f
a bond
H
a bond
NH
S
a bond
Q3b
OH


2058
CMe
NMe
Q1f
a bond
H
a bond
NH
S
a bond
Q3c
OH


2059
CMe
NMe
Q1f
a bond
H
a bond
NH
O
NH
Q3a
OH


2060
CMe
NMe
Q1f
a bond
H
a bond
NH
O
NH
Q3b
OH


2061
CMe
NMe
Q1f
a bond
H
a bond
NH
O
NH
Q3c
OH


2062
CMe
NMe
Q1f
a bond
H
a bond
NH
O
a bond
Q3a
OH


2063
CMe
NMe
Q1f
a bond
H
a bond
NH
O
a bond
Q3b
OH


2064
CMe
NMe
Q1f
a bond
H
a bond
NH
O
a bond
Q3c
OH


2065
CMe
NMe
Q1g
a bond
Me
a bond
NH
S
NH
Q3a
OH


2066
CMe
NMe
Q1g
a bond
Me
a bond
NH
S
NH
Q3b
OH


2067
CMe
NMe
Q1g
a bond
Me
a bond
NH
S
NH
Q3c
OH


2068
CMe
NMe
Q1g
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2069
CMe
NMe
Q1g
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2070
CMe
NMe
Q1g
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2071
CMe
NMe
Q1g
a bond
Me
a bond
NH
O
NH
Q3a
OH


2072
CMe
NMe
Q1g
a bond
Me
a bond
NH
O
NH
Q3b
OH


2073
CMe
NMe
Q1g
a bond
Me
a bond
NH
O
NH
Q3c
OH


2074
CMe
NMe
Q1g
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2075
CMe
NMe
Q1g
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2076
CMe
NMe
Q1g
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2077
CMe
NMe
Q1g
a bond
H
a bond
NH
S
NH
Q3a
OH


2078
CMe
NMe
Q1g
a bond
H
a bond
NH
S
NH
Q3b
OH


2079
CMe
NMe
Q1g
a bond
H
a bond
NH
S
NH
Q3c
OH


2080
CMe
NMe
Q1g
a bond
H
a bond
NH
S
a bond
Q3a
OH


2081
CMe
NMe
Q1g
a bond
H
a bond
NH
S
a bond
Q3b
OH


2082
CMe
NMe
Q1g
a bond
H
a bond
NH
S
a bond
Q3c
OH


2083
CMe
NMe
Q1g
a bond
H
a bond
NH
O
NH
Q3a
OH


2084
CMe
NMe
Q1g
a bond
H
a bond
NH
O
NH
Q3b
OH


2085
CMe
NMe
Q1g
a bond
H
a bond
NH
O
NH
Q3c
OH


2086
CMe
NMe
Q1g
a bond
H
a bond
NH
O
a bond
Q3a
OH


2087
CMe
NMe
Q1g
a bond
H
a bond
NH
O
a bond
Q3b
OH


2088
CMe
NMe
Q1g
a bond
H
a bond
NH
O
a bond
Q3c
OH


2089
CMe
NMe
Q1h
a bond
Me
a bond
NH
S
NH
Q3a
OH


2090
CMe
NMe
Q1h
a bond
Me
a bond
NH
S
NH
Q3b
OH


2091
CMe
NMe
Q1h
a bond
Me
a bond
NH
S
NH
Q3c
OH


2092
CMe
NMe
Q1h
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2093
CMe
NMe
Q1h
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2094
CMe
NMe
Q1h
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2095
CMe
NMe
Q1h
a bond
Me
a bond
NH
O
NH
Q3a
OH


2096
CMe
NMe
Q1h
a bond
Me
a bond
NH
O
NH
Q3b
OH


2097
CMe
NMe
Q1h
a bond
Me
a bond
NH
O
NH
Q3c
OH


2098
CMe
NMe
Q1h
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2099
CMe
NMe
Q1h
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2100
CMe
NMe
Q1h
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2101
CMe
NMe
Q1h
a bond
H
a bond
NH
S
NH
Q3a
OH


2102
CMe
NMe
Q1h
a bond
H
a bond
NH
S
NH
Q3b
OH


2103
CMe
NMe
Q1h
a bond
H
a bond
NH
S
NH
Q3c
OH


2104
CMe
NMe
Q1h
a bond
H
a bond
NH
S
a bond
Q3a
OH


2105
CMe
NMe
Q1h
a bond
H
a bond
NH
S
a bond
Q3b
OH


2106
CMe
NMe
Q1h
a bond
H
a bond
NH
S
a bond
Q3c
OH


2107
CMe
NMe
Q1h
a bond
H
a bond
NH
O
NH
Q3a
OH


2108
CMe
NMe
Q1h
a bond
H
a bond
NH
O
NH
Q3b
OH


2109
CMe
NMe
Q1h
a bond
H
a bond
NH
O
NH
Q3c
OH


2110
CMe
NMe
Q1h
a bond
H
a bond
NH
O
a bond
Q3a
OH


2111
CMe
NMe
Q1h
a bond
H
a bond
NH
O
a bond
Q3b
OH


2112
CMe
NMe
Q1h
a bond
H
a bond
NH
O
a bond
Q3c
OH


2113
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
NH
Q3a
OH


2114
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
NH
Q3b
OH


2115
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
NH
Q3c
OH


2116
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2117
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2118
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2119
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
NH
Q3a
OH


2120
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
NH
Q3b
OH


2121
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
NH
Q3c
OH


2122
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2123
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2124
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2125
CMe
NMe
Q1i
a bond
H
a bond
NH
S
NH
Q3a
OH


2126
CMe
NMe
Q1i
a bond
H
a bond
NH
S
NH
Q3b
OH


2127
CMe
NMe
Q1i
a bond
H
a bond
NH
S
NH
Q3c
OH


2128
CMe
NMe
Q1i
a bond
H
a bond
NH
S
a bond
Q3a
OH


2129
CMe
NMe
Q1i
a bond
H
a bond
NH
S
a bond
Q3b
OH


2130
CMe
NMe
Q1i
a bond
H
a bond
NH
S
a bond
Q3c
OH


2131
CMe
NMe
Q1i
a bond
H
a bond
NH
O
NH
Q3a
OH


2132
CMe
NMe
Q1i
a bond
H
a bond
NH
O
NH
Q3b
OH


2133
CMe
NMe
Q1i
a bond
H
a bond
NH
O
NH
Q3c
OH


2134
CMe
NMe
Q1i
a bond
H
a bond
NH
O
a bond
Q3a
OH


2135
CMe
NMe
Q1i
a bond
H
a bond
NH
O
a bond
Q3b
OH


2136
CMe
NMe
Q1i
a bond
H
a bond
NH
O
a bond
Q3c
OH


2137
CMe
NMe
Q1j
a bond
Me
a bond
NH
S
NH
Q3a
OH


2138
CMe
NMe
Q1j
a bond
Me
a bond
NH
S
NH
Q3b
OH


2139
CMe
NMe
Q1j
a bond
Me
a bond
NH
S
NH
Q3c
OH


2140
CMe
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2141
CMe
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2142
CMe
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2143
CMe
NMe
Q1j
a bond
Me
a bond
NH
O
NH
Q3a
OH


2144
CMe
NMe
Q1j
a bond
Me
a bond
NH
O
NH
Q3b
OH


2145
CMe
NMe
Q1j
a bond
Me
a bond
NH
O
NH
Q3c
OH


2146
CMe
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2147
CMe
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2148
CMe
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2149
CMe
NMe
Q1j
a bond
H
a bond
NH
S
NH
Q3a
OH


2150
CMe
NMe
Q1j
a bond
H
a bond
NH
S
NH
Q3b
OH


2151
CMe
NMe
Q1j
a bond
H
a bond
NH
S
NH
Q3c
OH


2152
CMe
NMe
Q1j
a bond
H
a bond
NH
S
a bond
Q3a
OH


2153
CMe
NMe
Q1j
a bond
H
a bond
NH
S
a bond
Q3b
OH


2154
CMe
NMe
Q1j
a bond
H
a bond
NH
S
a bond
Q3c
OH


2155
CMe
NMe
Q1j
a bond
H
a bond
NH
O
NH
Q3a
OH


2156
CMe
NMe
Q1j
a bond
H
a bond
NH
O
NH
Q3b
OH


2157
CMe
NMe
Q1j
a bond
H
a bond
NH
O
NH
Q3c
OH


2158
CMe
NMe
Q1j
a bond
H
a bond
NH
O
a bond
Q3a
OH


2159
CMe
NMe
Q1j
a bond
H
a bond
NH
O
a bond
Q3b
OH


2160
CMe
NMe
Q1j
a bond
H
a bond
NH
O
a bond
Q3c
OH


2161
CMe
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3a
OH


2162
CMe
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3b
OH


2163
CMe
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3c
OH


2164
CMe
NEt
Q1a
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2165
CMe
NEt
Q1a
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2166
CMe
NEt
Q1a
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2167
CMe
NEt
Q1a
a bond
Me
a bond
NH
O
NH
Q3a
OH


2168
CMe
NEt
Q1a
a bond
Me
a bond
NH
O
NH
Q3b
OH


2169
CMe
NEt
Q1a
a bond
Me
a bond
NH
O
NH
Q3c
OH


2170
CMe
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2171
CMe
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2172
CMe
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2173
CMe
NEt
Q1a
a bond
H
a bond
NH
S
NH
Q3a
OH


2174
CMe
NEt
Q1a
a bond
H
a bond
NH
S
NH
Q3b
OH


2175
CMe
NEt
Q1a
a bond
H
a bond
NH
S
NH
Q3c
OH


2176
CMe
NEt
Q1a
a bond
H
a bond
NH
S
a bond
Q3a
OH


2177
CMe
NEt
Q1a
a bond
H
a bond
NH
S
a bond
Q3b
OH


2178
CMe
NEt
Q1a
a bond
H
a bond
NH
S
a bond
Q3c
OH


2179
CMe
NEt
Q1a
a bond
H
a bond
NH
O
NH
Q3a
OH


2180
CMe
NEt
Q1a
a bond
H
a bond
NH
O
NH
Q3b
OH


2181
CMe
NEt
Q1a
a bond
H
a bond
NH
O
NH
Q3c
OH


2182
CMe
NEt
Q1a
a bond
H
a bond
NH
O
a bond
Q3a
OH


2183
CMe
NEt
Q1a
a bond
H
a bond
NH
O
a bond
Q3b
OH


2184
CMe
NEt
Q1a
a bond
H
a bond
NH
O
a bond
Q3c
OH


2185
CMe
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3a
OH


2186
CMe
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3b
OH


2187
CMe
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3c
OH


2188
CMe
NEt
Q1b
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2189
CMe
NEt
Q1b
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2190
CMe
NEt
Q1b
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2191
CMe
NEt
Q1b
a bond
Me
a bond
NH
O
NH
Q3a
OH


2192
CMe
NEt
Q1b
a bond
Me
a bond
NH
O
NH
Q3b
OH


2193
CMe
NEt
Q1b
a bond
Me
a bond
NH
O
NH
Q3c
OH


2194
CMe
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2195
CMe
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2196
CMe
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2197
CMe
NEt
Q1b
a bond
H
a bond
NH
S
NH
Q3a
OH


2198
CMe
NEt
Q1b
a bond
H
a bond
NH
S
NH
Q3b
OH


2199
CMe
NEt
Q1b
a bond
H
a bond
NH
S
NH
Q3c
OH


2200
CMe
NEt
Q1b
a bond
H
a bond
NH
S
a bond
Q3a
OH


2201
CMe
NEt
Q1b
a bond
H
a bond
NH
S
a bond
Q3b
OH


2202
CMe
NEt
Q1b
a bond
H
a bond
NH
S
a bond
Q3c
OH


2203
CMe
NEt
Q1b
a bond
H
a bond
NH
O
NH
Q3a
OH


2204
CMe
NEt
Q1b
a bond
H
a bond
NH
O
NH
Q3b
OH


2205
CMe
NEt
Q1b
a bond
H
a bond
NH
O
NH
Q3c
OH


2206
CMe
NEt
Q1b
a bond
H
a bond
NH
O
a bond
Q3a
OH


2207
CMe
NEt
Q1b
a bond
H
a bond
NH
O
a bond
Q3b
OH


2208
CMe
NEt
Q1b
a bond
H
a bond
NH
O
a bond
Q3c
OH


2209
CMe
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3a
OH


2210
CMe
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3b
OH


2211
CMe
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3c
OH


2212
CMe
NEt
Q1c
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2213
CMe
NEt
Q1c
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2214
CMe
NEt
Q1c
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2215
CMe
NEt
Q1c
a bond
Me
a bond
NH
O
NH
Q3a
OH


2216
CMe
NEt
Q1c
a bond
Me
a bond
NH
O
NH
Q3b
OH


2217
CMe
NEt
Q1c
a bond
Me
a bond
NH
O
NH
Q3c
OH


2218
CMe
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2219
CMe
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2220
CMe
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2221
CMe
NEt
Q1c
a bond
H
a bond
NH
S
NH
Q3a
OH


2222
CMe
NEt
Q1c
a bond
H
a bond
NH
S
NH
Q3b
OH


2223
CMe
NEt
Q1c
a bond
H
a bond
NH
S
NH
Q3c
OH


2224
CMe
NEt
Q1c
a bond
H
a bond
NH
S
a bond
Q3a
OH


2225
CMe
NEt
Q1c
a bond
H
a bond
NH
S
a bond
Q3b
OH


2226
CMe
NEt
Q1c
a bond
H
a bond
NH
S
a bond
Q3c
OH


2227
CMe
NEt
Q1c
a bond
H
a bond
NH
O
NH
Q3a
OH


2228
CMe
NEt
Q1c
a bond
H
a bond
NH
O
NH
Q3b
OH


2229
CMe
NEt
Q1c
a bond
H
a bond
NH
O
NH
Q3c
OH


2230
CMe
NEt
Q1c
a bond
H
a bond
NH
O
a bond
Q3a
OH


2231
CMe
NEt
Q1c
a bond
H
a bond
NH
O
a bond
Q3b
OH


2232
CMe
NEt
Q1c
a bond
H
a bond
NH
O
a bond
Q3c
OH


2233
CMe
NEt
Q1d
a bond
Me
a bond
NH
S
NH
Q3a
OH


2234
CMe
NEt
Q1d
a bond
Me
a bond
NH
S
NH
Q3b
OH


2235
CMe
NEt
Q1d
a bond
Me
a bond
NH
S
NH
Q3c
OH


2236
CMe
NEt
Q1d
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2237
CMe
NEt
Q1d
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2238
CMe
NEt
Q1d
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2239
CMe
NEt
Q1d
a bond
Me
a bond
NH
O
NH
Q3a
OH


2240
CMe
NEt
Q1d
a bond
Me
a bond
NH
O
NH
Q3b
OH


2241
CMe
NEt
Q1d
a bond
Me
a bond
NH
O
NH
Q3c
OH


2242
CMe
NEt
Q1d
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2243
CMe
NEt
Q1d
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2244
CMe
NEt
Q1d
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2245
CMe
NEt
Q1d
a bond
H
a bond
NH
S
NH
Q3a
OH


2246
CMe
NEt
Q1d
a bond
H
a bond
NH
S
NH
Q3b
OH


2247
CMe
NEt
Q1d
a bond
H
a bond
NH
S
NH
Q3c
OH


2248
CMe
NEt
Q1d
a bond
H
a bond
NH
S
a bond
Q3a
OH


2249
CMe
NEt
Q1d
a bond
H
a bond
NH
S
a bond
Q3b
OH


2250
CMe
NEt
Q1d
a bond
H
a bond
NH
S
a bond
Q3c
OH


2251
CMe
NEt
Q1d
a bond
H
a bond
NH
O
NH
Q3a
OH


2252
CMe
NEt
Q1d
a bond
H
a bond
NH
O
NH
Q3b
OH


2253
CMe
NEt
Q1d
a bond
H
a bond
NH
O
NH
Q3c
OH


2254
CMe
NEt
Q1d
a bond
H
a bond
NH
O
a bond
Q3a
OH


2255
CMe
NEt
Q1d
a bond
H
a bond
NH
O
a bond
Q3b
OH


2256
CMe
NEt
Q1d
a bond
H
a bond
NH
O
a bond
Q3c
OH


2257
CMe
NEt
Q1e
a bond
Me
a bond
NH
S
NH
Q3a
OH


2258
CMe
NEt
Q1e
a bond
Me
a bond
NH
S
NH
Q3b
OH


2259
CMe
NEt
Q1e
a bond
Me
a bond
NH
S
NH
Q3c
OH


2260
CMe
NEt
Q1e
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2261
CMe
NEt
Q1e
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2262
CMe
NEt
Q1e
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2263
CMe
NEt
Q1e
a bond
Me
a bond
NH
O
NH
Q3a
OH


2264
CMe
NEt
Q1e
a bond
Me
a bond
NH
O
NH
Q3b
OH


2265
CMe
NEt
Q1e
a bond
Me
a bond
NH
O
NH
Q3c
OH


2266
CMe
NEt
Q1e
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2267
CMe
NEt
Q1e
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2268
CMe
NEt
Q1e
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2269
CMe
NEt
Q1e
a bond
H
a bond
NH
S
NH
Q3a
OH


2270
CMe
NEt
Q1e
a bond
H
a bond
NH
S
NH
Q3b
OH


2271
CMe
NEt
Q1e
a bond
H
a bond
NH
S
NH
Q3c
OH


2272
CMe
NEt
Q1e
a bond
H
a bond
NH
S
a bond
Q3a
OH


2273
CMe
NEt
Q1e
a bond
H
a bond
NH
S
a bond
Q3b
OH


2274
CMe
NEt
Q1e
a bond
H
a bond
NH
S
a bond
Q3c
OH


2275
CMe
NEt
Q1e
a bond
H
a bond
NH
O
NH
Q3a
OH


2276
CMe
NEt
Q1e
a bond
H
a bond
NH
O
NH
Q3b
OH


2277
CMe
NEt
Q1e
a bond
H
a bond
NH
O
NH
Q3c
OH


2278
CMe
NEt
Q1e
a bond
H
a bond
NH
O
a bond
Q3a
OH


2279
CMe
NEt
Q1e
a bond
H
a bond
NH
O
a bond
Q3b
OH


2280
CMe
NEt
Q1e
a bond
H
a bond
NH
O
a bond
Q3c
OH


2281
CMe
NEt
Q1f
a bond
Me
a bond
NH
S
NH
Q3a
OH


2282
CMe
NEt
Q1f
a bond
Me
a bond
NH
S
NH
Q3b
OH


2283
CMe
NEt
Q1f
a bond
Me
a bond
NH
S
NH
Q3c
OH


2284
CMe
NEt
Q1f
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2285
CMe
NEt
Q1f
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2286
CMe
NEt
Q1f
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2287
CMe
NEt
Q1f
a bond
Me
a bond
NH
O
NH
Q3a
OH


2288
CMe
NEt
Q1f
a bond
Me
a bond
NH
O
NH
Q3b
OH


2289
CMe
NEt
Q1f
a bond
Me
a bond
NH
O
NH
Q3c
OH


2290
CMe
NEt
Q1f
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2291
CMe
NEt
Q1f
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2292
CMe
NEt
Q1f
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2293
CMe
NEt
Q1f
a bond
H
a bond
NH
S
NH
Q3a
OH


2294
CMe
NEt
Q1f
a bond
H
a bond
NH
S
NH
Q3b
OH


2295
CMe
NEt
Q1f
a bond
H
a bond
NH
S
NH
Q3c
OH


2296
CMe
NEt
Q1f
a bond
H
a bond
NH
S
a bond
Q3a
OH


2297
CMe
NEt
Q1f
a bond
H
a bond
NH
S
a bond
Q3b
OH


2298
CMe
NEt
Q1f
a bond
H
a bond
NH
S
a bond
Q3c
OH


2299
CMe
NEt
Q1f
a bond
H
a bond
NH
O
NH
Q3a
OH


2300
CMe
NEt
Q1f
a bond
H
a bond
NH
O
NH
Q3b
OH


2301
CMe
NEt
Q1f
a bond
H
a bond
NH
O
NH
Q3c
OH


2302
CMe
NEt
Q1f
a bond
H
a bond
NH
O
a bond
Q3a
OH


2303
CMe
NEt
Q1f
a bond
H
a bond
NH
O
a bond
Q3b
OH


2304
CMe
NEt
Q1f
a bond
H
a bond
NH
O
a bond
Q3c
OH


2305
CMe
NEt
Q1g
a bond
Me
a bond
NH
S
NH
Q3a
OH


2306
CMe
NEt
Q1g
a bond
Me
a bond
NH
S
NH
Q3b
OH


2307
CMe
NEt
Q1g
a bond
Me
a bond
NH
S
NH
Q3c
OH


2308
CMe
NEt
Q1g
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2309
CMe
NEt
Q1g
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2310
CMe
NEt
Q1g
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2311
CMe
NEt
Q1g
a bond
Me
a bond
NH
O
NH
Q3a
OH


2312
CMe
NEt
Q1g
a bond
Me
a bond
NH
O
NH
Q3b
OH


2313
CMe
NEt
Q1g
a bond
Me
a bond
NH
O
NH
Q3c
OH


2314
CMe
NEt
Q1g
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2315
CMe
NEt
Q1g
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2316
CMe
NEt
Q1g
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2317
CMe
NEt
Q1g
a bond
H
a bond
NH
S
NH
Q3a
OH


2318
CMe
NEt
Q1g
a bond
H
a bond
NH
S
NH
Q3b
OH


2319
CMe
NEt
Q1g
a bond
H
a bond
NH
S
NH
Q3c
OH


2320
CMe
NEt
Q1g
a bond
H
a bond
NH
S
a bond
Q3a
OH


2321
CMe
NEt
Q1g
a bond
H
a bond
NH
S
a bond
Q3b
OH


2322
CMe
NEt
Q1g
a bond
H
a bond
NH
S
a bond
Q3c
OH


2323
CMe
NEt
Q1g
a bond
H
a bond
NH
O
NH
Q3a
OH


2324
CMe
NEt
Q1g
a bond
H
a bond
NH
O
NH
Q3b
OH


2325
CMe
NEt
Q1g
a bond
H
a bond
NH
O
NH
Q3c
OH


2326
CMe
NEt
Q1g
a bond
H
a bond
NH
O
a bond
Q3a
OH


2327
CMe
NEt
Q1g
a bond
H
a bond
NH
O
a bond
Q3b
OH


2328
CMe
NEt
Q1g
a bond
H
a bond
NH
O
a bond
Q3c
OH


2329
CMe
NEt
Q1h
a bond
Me
a bond
NH
S
NH
Q3a
OH


2330
CMe
NEt
Q1h
a bond
Me
a bond
NH
S
NH
Q3b
OH


2331
CMe
NEt
Q1h
a bond
Me
a bond
NH
S
NH
Q3c
OH


2332
CMe
NEt
Q1h
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2333
CMe
NEt
Q1h
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2334
CMe
NEt
Q1h
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2335
CMe
NEt
Q1h
a bond
Me
a bond
NH
O
NH
Q3a
OH


2336
CMe
NEt
Q1h
a bond
Me
a bond
NH
O
NH
Q3b
OH


2337
CMe
NEt
Q1h
a bond
Me
a bond
NH
O
NH
Q3c
OH


2338
CMe
NEt
Q1h
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2339
CMe
NEt
Q1h
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2340
CMe
NEt
Q1h
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2341
CMe
NEt
Q1h
a bond
H
a bond
NH
S
NH
Q3a
OH


2342
CMe
NEt
Q1h
a bond
H
a bond
NH
S
NH
Q3b
OH


2343
CMe
NEt
Q1h
a bond
H
a bond
NH
S
NH
Q3c
OH


2344
CMe
NEt
Q1h
a bond
H
a bond
NH
S
a bond
Q3a
OH


2345
CMe
NEt
Q1h
a bond
H
a bond
NH
S
a bond
Q3b
OH


2346
CMe
NEt
Q1h
a bond
H
a bond
NH
S
a bond
Q3c
OH


2347
CMe
NEt
Q1h
a bond
H
a bond
NH
O
NH
Q3a
OH


2348
CMe
NEt
Q1h
a bond
H
a bond
NH
O
NH
Q3b
OH


2349
CMe
NEt
Q1h
a bond
H
a bond
NH
O
NH
Q3c
OH


2350
CMe
NEt
Q1h
a bond
H
a bond
NH
O
a bond
Q3a
OH


2351
CMe
NEt
Q1h
a bond
H
a bond
NH
O
a bond
Q3b
OH


2352
CMe
NEt
Q1h
a bond
H
a bond
NH
O
a bond
Q3c
OH


2353
CMe
NEt
Q1i
a bond
Me
a bond
NH
S
NH
Q3a
OH


2354
CMe
NEt
Q1i
a bond
Me
a bond
NH
S
NH
Q3b
OH


2355
CMe
NEt
Q1i
a bond
Me
a bond
NH
S
NH
Q3c
OH


2356
CMe
NEt
Q1i
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2357
CMe
NEt
Q1i
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2358
CMe
NEt
Q1i
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2359
CMe
NEt
Q1i
a bond
Me
a bond
NH
O
NH
Q3a
OH


2360
CMe
NEt
Q1i
a bond
Me
a bond
NH
O
NH
Q3b
OH


2361
CMe
NEt
Q1i
a bond
Me
a bond
NH
O
NH
Q3c
OH


2362
CMe
NEt
Q1i
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2363
CMe
NEt
Q1i
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2364
CMe
NEt
Q1i
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2365
CMe
NEt
Q1i
a bond
H
a bond
NH
S
NH
Q3a
OH


2366
CMe
NEt
Q1i
a bond
H
a bond
NH
S
NH
Q3b
OH


2367
CMe
NEt
Q1i
a bond
H
a bond
NH
S
NH
Q3c
OH


2368
CMe
NEt
Q1i
a bond
H
a bond
NH
S
a bond
Q3a
OH


2369
CMe
NEt
Q1i
a bond
H
a bond
NH
S
a bond
Q3b
OH


2370
CMe
NEt
Q1i
a bond
H
a bond
NH
S
a bond
Q3c
OH


2371
CMe
NEt
Q1i
a bond
H
a bond
NH
O
NH
Q3a
OH


2372
CMe
NEt
Q1i
a bond
H
a bond
NH
O
NH
Q3b
OH


2373
CMe
NEt
Q1i
a bond
H
a bond
NH
O
NH
Q3c
OH


2374
CMe
NEt
Q1i
a bond
H
a bond
NH
O
a bond
Q3a
OH


2375
CMe
NEt
Q1i
a bond
H
a bond
NH
O
a bond
Q3b
OH


2376
CMe
NEt
Q1i
a bond
H
a bond
NH
O
a bond
Q3c
OH


2377
CMe
NEt
Q1j
a bond
Me
a bond
NH
S
NH
Q3a
OH


2378
CMe
NEt
Q1j
a bond
Me
a bond
NH
S
NH
Q3b
OH


2379
CMe
NEt
Q1j
a bond
Me
a bond
NH
S
NH
Q3c
OH


2380
CMe
NEt
Q1j
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2381
CMe
NEt
Q1j
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2382
CMe
NEt
Q1j
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2383
CMe
NEt
Q1j
a bond
Me
a bond
NH
O
NH
Q3a
OH


2384
CMe
NEt
Q1j
a bond
Me
a bond
NH
O
NH
Q3b
OH


2385
CMe
NEt
Q1j
a bond
Me
a bond
NH
O
NH
Q3c
OH


2386
CMe
NEt
Q1j
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2387
CMe
NEt
Q1j
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2388
CMe
NEt
Q1j
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2389
CMe
NEt
Q1j
a bond
H
a bond
NH
S
NH
Q3a
OH


2390
CMe
NEt
Q1j
a bond
H
a bond
NH
S
NH
Q3b
OH


2391
CMe
NEt
Q1j
a bond
H
a bond
NH
S
NH
Q3c
OH


2392
CMe
NEt
Q1j
a bond
H
a bond
NH
S
a bond
Q3a
OH


2393
CMe
NEt
Q1j
a bond
H
a bond
NH
S
a bond
Q3b
OH


2394
CMe
NEt
Q1j
a bond
H
a bond
NH
S
a bond
Q3c
OH


2395
CMe
NEt
Q1j
a bond
H
a bond
NH
O
NH
Q3a
OH


2396
CMe
NEt
Q1j
a bond
H
a bond
NH
O
NH
Q3b
OH


2397
CMe
NEt
Q1j
a bond
H
a bond
NH
O
NH
Q3c
OH


2398
CMe
NEt
Q1j
a bond
H
a bond
NH
O
a bond
Q3a
OH


2399
CMe
NEt
Q1j
a bond
H
a bond
NH
O
a bond
Q3b
OH


2400
CMe
NEt
Q1j
a bond
H
a bond
NH
O
a bond
Q3c
OH


2401
CMe
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3a
OH


2402
CMe
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3b
OH


2403
CMe
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3c
OH


2404
CMe
S
Q1a
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2405
CMe
S
Q1a
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2406
CMe
S
Q1a
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2407
CMe
S
Q1a
a bond
Me
a bond
NH
O
NH
Q3a
OH


2408
CMe
S
Q1a
a bond
Me
a bond
NH
O
NH
Q3b
OH


2409
CMe
S
Q1a
a bond
Me
a bond
NH
O
NH
Q3c
OH


2410
CMe
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2411
CMe
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2412
CMe
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2413
CMe
S
Q1a
a bond
H
a bond
NH
S
NH
Q3a
OH


2414
CMe
S
Q1a
a bond
H
a bond
NH
S
NH
Q3b
OH


2415
CMe
S
Q1a
a bond
H
a bond
NH
S
NH
Q3c
OH


2416
CMe
S
Q1a
a bond
H
a bond
NH
S
a bond
Q3a
OH


2417
CMe
S
Q1a
a bond
H
a bond
NH
S
a bond
Q3b
OH


2418
CMe
S
Q1a
a bond
H
a bond
NH
S
a bond
Q3c
OH


2419
CMe
S
Q1a
a bond
H
a bond
NH
O
NH
Q3a
OH


2420
CMe
S
Q1a
a bond
H
a bond
NH
O
NH
Q3b
OH


2421
CMe
S
Q1a
a bond
H
a bond
NH
O
NH
Q3c
OH


2422
CMe
S
Q1a
a bond
H
a bond
NH
O
a bond
Q3a
OH


2423
CMe
S
Q1a
a bond
H
a bond
NH
O
a bond
Q3b
OH


2424
CMe
S
Q1a
a bond
H
a bond
NH
O
a bond
Q3c
OH


2425
CMe
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3a
OH


2426
CMe
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3b
OH


2427
CMe
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3c
OH


2428
CMe
S
Q1b
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2429
CMe
S
Q1b
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2430
CMe
S
Q1b
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2431
CMe
S
Q1b
a bond
Me
a bond
NH
O
NH
Q3a
OH


2432
CMe
S
Q1b
a bond
Me
a bond
NH
O
NH
Q3b
OH


2433
CMe
S
Q1b
a bond
Me
a bond
NH
O
NH
Q3c
OH


2434
CMe
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2435
CMe
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2436
CMe
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2437
CMe
S
Q1b
a bond
H
a bond
NH
S
NH
Q3a
OH


2438
CMe
S
Q1b
a bond
H
a bond
NH
S
NH
Q3b
OH


2439
CMe
S
Q1b
a bond
H
a bond
NH
S
NH
Q3c
OH


2440
CMe
S
Q1b
a bond
H
a bond
NH
S
a bond
Q3a
OH


2441
CMe
S
Q1b
a bond
H
a bond
NH
S
a bond
Q3b
OH


2442
CMe
S
Q1b
a bond
H
a bond
NH
S
a bond
Q3c
OH


2443
CMe
S
Q1b
a bond
H
a bond
NH
O
NH
Q3a
OH


2444
CMe
S
Q1b
a bond
H
a bond
NH
O
NH
Q3b
OH


2445
CMe
S
Q1b
a bond
H
a bond
NH
O
NH
Q3c
OH


2446
CMe
S
Q1b
a bond
H
a bond
NH
O
a bond
Q3a
OH


2447
CMe
S
Q1b
a bond
H
a bond
NH
O
a bond
Q3b
OH


2448
CMe
S
Q1b
a bond
H
a bond
NH
O
a bond
Q3c
OH


2449
CMe
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3a
OH


2450
CMe
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3b
OH


2451
CMe
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3c
OH


2452
CMe
S
Q1c
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2453
CMe
S
Q1c
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2454
CMe
S
Q1c
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2455
CMe
S
Q1c
a bond
Me
a bond
NH
O
NH
Q3a
OH


2456
CMe
S
Q1c
a bond
Me
a bond
NH
O
NH
Q3b
OH


2457
CMe
S
Q1c
a bond
Me
a bond
NH
O
NH
Q3c
OH


2458
CMe
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2459
CMe
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2460
CMe
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2461
CMe
S
Q1c
a bond
H
a bond
NH
S
NH
Q3a
OH


2462
CMe
S
Q1c
a bond
H
a bond
NH
S
NH
Q3b
OH


2463
CMe
S
Q1c
a bond
H
a bond
NH
S
NH
Q3c
OH


2464
CMe
S
Q1c
a bond
H
a bond
NH
S
a bond
Q3a
OH


2465
CMe
S
Q1c
a bond
H
a bond
NH
S
a bond
Q3b
OH


2466
CMe
S
Q1c
a bond
H
a bond
NH
S
a bond
Q3c
OH


2467
CMe
S
Q1c
a bond
H
a bond
NH
O
NH
Q3a
OH


2468
CMe
S
Q1c
a bond
H
a bond
NH
O
NH
Q3b
OH


2469
CMe
S
Q1c
a bond
H
a bond
NH
O
NH
Q3c
OH


2470
CMe
S
Q1c
a bond
H
a bond
NH
O
a bond
Q3a
OH


2471
CMe
S
Q1c
a bond
H
a bond
NH
O
a bond
Q3b
OH


2472
CMe
S
Q1c
a bond
H
a bond
NH
O
a bond
Q3c
OH


2473
CMe
S
Q1d
a bond
Me
a bond
NH
S
NH
Q3a
OH


2474
CMe
S
Q1d
a bond
Me
a bond
NH
S
NH
Q3b
OH


2475
CMe
S
Q1d
a bond
Me
a bond
NH
S
NH
Q3c
OH


2476
CMe
S
Q1d
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2477
CMe
S
Q1d
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2478
CMe
S
Q1d
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2479
CMe
S
Q1d
a bond
Me
a bond
NH
O
NH
Q3a
OH


2480
CMe
S
Q1d
a bond
Me
a bond
NH
O
NH
Q3b
OH


2481
CMe
S
Q1d
a bond
Me
a bond
NH
O
NH
Q3c
OH


2482
CMe
S
Q1d
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2483
CMe
S
Q1d
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2484
CMe
S
Q1d
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2485
CMe
S
Q1d
a bond
H
a bond
NH
S
NH
Q3a
OH


2486
CMe
S
Q1d
a bond
H
a bond
NH
S
NH
Q3b
OH


2487
CMe
S
Q1d
a bond
H
a bond
NH
S
NH
Q3c
OH


2488
CMe
S
Q1d
a bond
H
a bond
NH
S
a bond
Q3a
OH


2489
CMe
S
Q1d
a bond
H
a bond
NH
S
a bond
Q3b
OH


2490
CMe
S
Q1d
a bond
H
a bond
NH
S
a bond
Q3c
OH


2491
CMe
S
Q1d
a bond
H
a bond
NH
O
NH
Q3a
OH


2492
CMe
S
Q1d
a bond
H
a bond
NH
O
NH
Q3b
OH


2493
CMe
S
Q1d
a bond
H
a bond
NH
O
NH
Q3c
OH


2494
CMe
S
Q1d
a bond
H
a bond
NH
O
a bond
Q3a
OH


2495
CMe
S
Q1d
a bond
H
a bond
NH
O
a bond
Q3b
OH


2496
CMe
S
Q1d
a bond
H
a bond
NH
O
a bond
Q3c
OH


2497
CMe
S
Q1e
a bond
Me
a bond
NH
S
NH
Q3a
OH


2498
CMe
S
Q1e
a bond
Me
a bond
NH
S
NH
Q3b
OH


2499
CMe
S
Q1e
a bond
Me
a bond
NH
S
NH
Q3c
OH


2500
CMe
S
Q1e
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2501
CMe
S
Q1e
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2502
CMe
S
Q1e
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2503
CMe
S
Q1e
a bond
Me
a bond
NH
O
NH
Q3a
OH


2504
CMe
S
Q1e
a bond
Me
a bond
NH
O
NH
Q3b
OH


2505
CMe
S
Q1e
a bond
Me
a bond
NH
O
NH
Q3c
OH


2506
CMe
S
Q1e
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2507
CMe
S
Q1e
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2508
CMe
S
Q1e
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2509
CMe
S
Q1e
a bond
H
a bond
NH
S
NH
Q3a
OH


2510
CMe
S
Q1e
a bond
H
a bond
NH
S
NH
Q3b
OH


2511
CMe
S
Q1e
a bond
H
a bond
NH
S
NH
Q3c
OH


2512
CMe
S
Q1e
a bond
H
a bond
NH
S
a bond
Q3a
OH


2513
CMe
S
Q1e
a bond
H
a bond
NH
S
a bond
Q3b
OH


2514
CMe
S
Q1e
a bond
H
a bond
NH
S
a bond
Q3c
OH


2515
CMe
S
Q1e
a bond
H
a bond
NH
O
NH
Q3a
OH


2516
CMe
S
Q1e
a bond
H
a bond
NH
O
NH
Q3b
OH


2517
CMe
S
Q1e
a bond
H
a bond
NH
O
NH
Q3c
OH


2518
CMe
S
Q1e
a bond
H
a bond
NH
O
a bond
Q3a
OH


2519
CMe
S
Q1e
a bond
H
a bond
NH
O
a bond
Q3b
OH


2520
CMe
S
Q1e
a bond
H
a bond
NH
O
a bond
Q3c
OH


2521
CMe
S
Q1f
a bond
Me
a bond
NH
S
NH
Q3a
OH


2522
CMe
S
Q1f
a bond
Me
a bond
NH
S
NH
Q3b
OH


2523
CMe
S
Q1f
a bond
Me
a bond
NH
S
NH
Q3c
OH


2524
CMe
S
Q1f
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2525
CMe
S
Q1f
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2526
CMe
S
Q1f
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2527
CMe
S
Q1f
a bond
Me
a bond
NH
O
NH
Q3a
OH


2528
CMe
S
Q1f
a bond
Me
a bond
NH
O
NH
Q3b
OH


2529
CMe
S
Q1f
a bond
Me
a bond
NH
O
NH
Q3c
OH


2530
CMe
S
Q1f
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2531
CMe
S
Q1f
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2532
CMe
S
Q1f
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2533
CMe
S
Q1f
a bond
H
a bond
NH
S
NH
Q3a
OH


2534
CMe
S
Q1f
a bond
H
a bond
NH
S
NH
Q3b
OH


2535
CMe
S
Q1f
a bond
H
a bond
NH
S
NH
Q3c
OH


2536
CMe
S
Q1f
a bond
H
a bond
NH
S
a bond
Q3a
OH


2537
CMe
S
Q1f
a bond
H
a bond
NH
S
a bond
Q3b
OH


2538
CMe
S
Q1f
a bond
H
a bond
NH
S
a bond
Q3c
OH


2539
CMe
S
Q1f
a bond
H
a bond
NH
O
NH
Q3a
OH


2540
CMe
S
Q1f
a bond
H
a bond
NH
O
NH
Q3b
OH


2541
CMe
S
Q1f
a bond
H
a bond
NH
O
NH
Q3c
OH


2542
CMe
S
Q1f
a bond
H
a bond
NH
O
a bond
Q3a
OH


2543
CMe
S
Q1f
a bond
H
a bond
NH
O
a bond
Q3b
OH


2544
CMe
S
Q1f
a bond
H
a bond
NH
O
a bond
Q3c
OH


2545
CMe
S
Q1g
a bond
Me
a bond
NH
S
NH
Q3a
OH


2546
CMe
S
Q1g
a bond
Me
a bond
NH
S
NH
Q3b
OH


2547
CMe
S
Q1g
a bond
Me
a bond
NH
S
NH
Q3c
OH


2548
CMe
S
Q1g
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2549
CMe
S
Q1g
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2550
CMe
S
Q1g
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2551
CMe
S
Q1g
a bond
Me
a bond
NH
O
NH
Q3a
OH


2552
CMe
S
Q1g
a bond
Me
a bond
NH
O
NH
Q3b
OH


2553
CMe
S
Q1g
a bond
Me
a bond
NH
O
NH
Q3c
OH


2554
CMe
S
Q1g
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2555
CMe
S
Q1g
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2556
CMe
S
Q1g
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2557
CMe
S
Q1g
a bond
H
a bond
NH
S
NH
Q3a
OH


2558
CMe
S
Q1g
a bond
H
a bond
NH
S
NH
Q3b
OH


2559
CMe
S
Q1g
a bond
H
a bond
NH
S
NH
Q3c
OH


2560
CMe
S
Q1g
a bond
H
a bond
NH
S
a bond
Q3a
OH


2561
CMe
S
Q1g
a bond
H
a bond
NH
S
a bond
Q3b
OH


2562
CMe
S
Q1g
a bond
H
a bond
NH
S
a bond
Q3c
OH


2563
CMe
S
Q1g
a bond
H
a bond
NH
O
NH
Q3a
OH


2564
CMe
S
Q1g
a bond
H
a bond
NH
O
NH
Q3b
OH


2565
CMe
S
Q1g
a bond
H
a bond
NH
O
NH
Q3c
OH


2566
CMe
S
Q1g
a bond
H
a bond
NH
O
a bond
Q3a
OH


2567
CMe
S
Q1g
a bond
H
a bond
NH
O
a bond
Q3b
OH


2568
CMe
S
Q1g
a bond
H
a bond
NH
O
a bond
Q3c
OH


2569
CMe
S
Q1h
a bond
Me
a bond
NH
S
NH
Q3a
OH


2570
CMe
S
Q1h
a bond
Me
a bond
NH
S
NH
Q3b
OH


2571
CMe
S
Q1h
a bond
Me
a bond
NH
S
NH
Q3c
OH


2572
CMe
S
Q1h
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2573
CMe
S
Q1h
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2574
CMe
S
Q1h
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2575
CMe
S
Q1h
a bond
Me
a bond
NH
O
NH
Q3a
OH


2576
CMe
S
Q1h
a bond
Me
a bond
NH
O
NH
Q3b
OH


2577
CMe
S
Q1h
a bond
Me
a bond
NH
O
NH
Q3c
OH


2578
CMe
S
Q1h
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2579
CMe
S
Q1h
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2580
CMe
S
Q1h
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2581
CMe
S
Q1h
a bond
H
a bond
NH
S
NH
Q3a
OH


2582
CMe
S
Q1h
a bond
H
a bond
NH
S
NH
Q3b
OH


2583
CMe
S
Q1h
a bond
H
a bond
NH
S
NH
Q3c
OH


2584
CMe
S
Q1h
a bond
H
a bond
NH
S
a bond
Q3a
OH


2585
CMe
S
Q1h
a bond
H
a bond
NH
S
a bond
Q3b
OH


2586
CMe
S
Q1h
a bond
H
a bond
NH
S
a bond
Q3c
OH


2587
CMe
S
Q1h
a bond
H
a bond
NH
O
NH
Q3a
OH


2588
CMe
S
Q1h
a bond
H
a bond
NH
O
NH
Q3b
OH


2589
CMe
S
Q1h
a bond
H
a bond
NH
O
NH
Q3c
OH


2590
CMe
S
Q1h
a bond
H
a bond
NH
O
a bond
Q3a
OH


2591
CMe
S
Q1h
a bond
H
a bond
NH
O
a bond
Q3b
OH


2592
CMe
S
Q1h
a bond
H
a bond
NH
O
a bond
Q3c
OH


2593
CMe
S
Q1i
a bond
Me
a bond
NH
S
NH
Q3a
OH


2594
CMe
S
Q1i
a bond
Me
a bond
NH
S
NH
Q3b
OH


2595
CMe
S
Q1i
a bond
Me
a bond
NH
S
NH
Q3c
OH


2596
CMe
S
Q1i
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2597
CMe
S
Q1i
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2598
CMe
S
Q1i
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2599
CMe
S
Q1i
a bond
Me
a bond
NH
O
NH
Q3a
OH


2600
CMe
S
Q1i
a bond
Me
a bond
NH
O
NH
Q3b
OH


2601
CMe
S
Q1i
a bond
Me
a bond
NH
O
NH
Q3c
OH


2602
CMe
S
Q1i
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2603
CMe
S
Q1i
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2604
CMe
S
Q1i
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2605
CMe
S
Q1i
a bond
H
a bond
NH
S
NH
Q3a
OH


2606
CMe
S
Q1i
a bond
H
a bond
NH
S
NH
Q3b
OH


2607
CMe
S
Q1i
a bond
H
a bond
NH
S
NH
Q3c
OH


2608
CMe
S
Q1i
a bond
H
a bond
NH
S
a bond
Q3a
OH


2609
CMe
S
Q1i
a bond
H
a bond
NH
S
a bond
Q3b
OH


2610
CMe
S
Q1i
a bond
H
a bond
NH
S
a bond
Q3c
OH


2611
CMe
S
Q1i
a bond
H
a bond
NH
O
NH
Q3a
OH


2612
CMe
S
Q1i
a bond
H
a bond
NH
O
NH
Q3b
OH


2613
CMe
S
Q1i
a bond
H
a bond
NH
O
NH
Q3c
OH


2614
CMe
S
Q1i
a bond
H
a bond
NH
O
a bond
Q3a
OH


2615
CMe
S
Q1i
a bond
H
a bond
NH
O
a bond
Q3b
OH


2616
CMe
S
Q1i
a bond
H
a bond
NH
O
a bond
Q3c
OH


2617
CMe
S
Q1j
a bond
Me
a bond
NH
S
NH
Q3a
OH


2618
CMe
S
Q1j
a bond
Me
a bond
NH
S
NH
Q3b
OH


2619
CMe
S
Q1j
a bond
Me
a bond
NH
S
NH
Q3c
OH


2620
CMe
S
Q1j
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2621
CMe
S
Q1j
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2622
CMe
S
Q1j
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2623
CMe
S
Q1j
a bond
Me
a bond
NH
O
NH
Q3a
OH


2624
CMe
S
Q1j
a bond
Me
a bond
NH
O
NH
Q3b
OH


2625
CMe
S
Q1j
a bond
Me
a bond
NH
O
NH
Q3c
OH


2626
CMe
S
Q1j
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2627
CMe
S
Q1j
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2628
CMe
S
Q1j
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2629
CMe
S
Q1j
a bond
H
a bond
NH
S
NH
Q3a
OH


2630
CMe
S
Q1j
a bond
H
a bond
NH
S
NH
Q3b
OH


2631
CMe
S
Q1j
a bond
H
a bond
NH
S
NH
Q3c
OH


2632
CMe
S
Q1j
a bond
H
a bond
NH
S
a bond
Q3a
OH


2633
CMe
S
Q1j
a bond
H
a bond
NH
S
a bond
Q3b
OH


2634
CMe
S
Q1j
a bond
H
a bond
NH
S
a bond
Q3c
OH


2635
CMe
S
Q1j
a bond
H
a bond
NH
O
NH
Q3a
OH


2636
CMe
S
Q1j
a bond
H
a bond
NH
O
NH
Q3b
OH


2637
CMe
S
Q1j
a bond
H
a bond
NH
O
NH
Q3c
OH


2638
CMe
S
Q1j
a bond
H
a bond
NH
O
a bond
Q3a
OH


2639
CMe
S
Q1j
a bond
H
a bond
NH
O
a bond
Q3b
OH


2640
CMe
S
Q1j
a bond
H
a bond
NH
O
a bond
Q3c
OH


2641
CMe
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3a
OH


2642
CMe
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3b
OH


2643
CMe
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3c
OH


2644
CMe
O
Q1a
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2645
CMe
O
Q1a
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2646
CMe
O
Q1a
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2647
CMe
O
Q1a
a bond
Me
a bond
NH
O
NH
Q3a
OH


2648
CMe
O
Q1a
a bond
Me
a bond
NH
O
NH
Q3b
OH


2649
CMe
O
Q1a
a bond
Me
a bond
NH
O
NH
Q3c
OH


2650
CMe
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2651
CMe
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2652
CMe
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2653
CMe
O
Q1a
a bond
H
a bond
NH
S
NH
Q3a
OH


2654
CMe
O
Q1a
a bond
H
a bond
NH
S
NH
Q3b
OH


2655
CMe
O
Q1a
a bond
H
a bond
NH
S
NH
Q3c
OH


2656
CMe
O
Q1a
a bond
H
a bond
NH
S
a bond
Q3a
OH


2657
CMe
O
Q1a
a bond
H
a bond
NH
S
a bond
Q3b
OH


2658
CMe
O
Q1a
a bond
H
a bond
NH
S
a bond
Q3c
OH


2659
CMe
O
Q1a
a bond
H
a bond
NH
O
NH
Q3a
OH


2660
CMe
O
Q1a
a bond
H
a bond
NH
O
NH
Q3b
OH


2661
CMe
O
Q1a
a bond
H
a bond
NH
O
NH
Q3c
OH


2662
CMe
O
Q1a
a bond
H
a bond
NH
O
a bond
Q3a
OH


2663
CMe
O
Q1a
a bond
H
a bond
NH
O
a bond
Q3b
OH


2664
CMe
O
Q1a
a bond
H
a bond
NH
O
a bond
Q3c
OH


2665
CMe
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3a
OH


2666
CMe
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3b
OH


2667
CMe
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3c
OH


2668
CMe
O
Q1b
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2669
CMe
O
Q1b
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2670
CMe
O
Q1b
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2671
CMe
O
Q1b
a bond
Me
a bond
NH
O
NH
Q3a
OH


2672
CMe
O
Q1b
a bond
Me
a bond
NH
O
NH
Q3b
OH


2673
CMe
O
Q1b
a bond
Me
a bond
NH
O
NH
Q3c
OH


2674
CMe
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2675
CMe
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2676
CMe
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2677
CMe
O
Q1b
a bond
H
a bond
NH
S
NH
Q3a
OH


2678
CMe
O
Q1b
a bond
H
a bond
NH
S
NH
Q3b
OH


2679
CMe
O
Q1b
a bond
H
a bond
NH
S
NH
Q3c
OH


2680
CMe
O
Q1b
a bond
H
a bond
NH
S
a bond
Q3a
OH


2681
CMe
O
Q1b
a bond
H
a bond
NH
S
a bond
Q3b
OH


2682
CMe
O
Q1b
a bond
H
a bond
NH
S
a bond
Q3c
OH


2683
CMe
O
Q1b
a bond
H
a bond
NH
O
NH
Q3a
OH


2684
CMe
O
Q1b
a bond
H
a bond
NH
O
NH
Q3b
OH


2685
CMe
O
Q1b
a bond
H
a bond
NH
O
NH
Q3c
OH


2686
CMe
O
Q1b
a bond
H
a bond
NH
O
a bond
Q3a
OH


2687
CMe
O
Q1b
a bond
H
a bond
NH
O
a bond
Q3b
OH


2688
CMe
O
Q1b
a bond
H
a bond
NH
O
a bond
Q3c
OH


2689
CMe
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3a
OH


2690
CMe
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3b
OH


2691
CMe
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3c
OH


2692
CMe
O
Q1c
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2693
CMe
O
Q1c
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2694
CMe
O
Q1c
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2695
CMe
O
Q1c
a bond
Me
a bond
NH
O
NH
Q3a
OH


2696
CMe
O
Q1c
a bond
Me
a bond
NH
O
NH
Q3b
OH


2697
CMe
O
Q1c
a bond
Me
a bond
NH
O
NH
Q3c
OH


2698
CMe
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2699
CMe
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2700
CMe
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2701
CMe
O
Q1c
a bond
H
a bond
NH
S
NH
Q3a
OH


2702
CMe
O
Q1c
a bond
H
a bond
NH
S
NH
Q3b
OH


2703
CMe
O
Q1c
a bond
H
a bond
NH
S
NH
Q3c
OH


2704
CMe
O
Q1c
a bond
H
a bond
NH
S
a bond
Q3a
OH


2705
CMe
O
Q1c
a bond
H
a bond
NH
S
a bond
Q3b
OH


2706
CMe
O
Q1c
a bond
H
a bond
NH
S
a bond
Q3c
OH


2707
CMe
O
Q1c
a bond
H
a bond
NH
O
NH
Q3a
OH


2708
CMe
O
Q1c
a bond
H
a bond
NH
O
NH
Q3b
OH


2709
CMe
O
Q1c
a bond
H
a bond
NH
O
NH
Q3c
OH


2710
CMe
O
Q1c
a bond
H
a bond
NH
O
a bond
Q3a
OH


2711
CMe
O
Q1c
a bond
H
a bond
NH
O
a bond
Q3b
OH


2712
CMe
O
Q1c
a bond
H
a bond
NH
O
a bond
Q3c
OH


2713
CMe
O
Q1d
a bond
Me
a bond
NH
S
NH
Q3a
OH


2714
CMe
O
Q1d
a bond
Me
a bond
NH
S
NH
Q3b
OH


2715
CMe
O
Q1d
a bond
Me
a bond
NH
S
NH
Q3c
OH


2716
CMe
O
Q1d
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2717
CMe
O
Q1d
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2718
CMe
O
Q1d
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2719
CMe
O
Q1d
a bond
Me
a bond
NH
O
NH
Q3a
OH


2720
CMe
O
Q1d
a bond
Me
a bond
NH
O
NH
Q3b
OH


2721
CMe
O
Q1d
a bond
Me
a bond
NH
O
NH
Q3c
OH


2722
CMe
O
Q1d
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2723
CMe
O
Q1d
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2724
CMe
O
Q1d
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2725
CMe
O
Q1d
a bond
H
a bond
NH
S
NH
Q3a
OH


2726
CMe
O
Q1d
a bond
H
a bond
NH
S
NH
Q3b
OH


2727
CMe
O
Q1d
a bond
H
a bond
NH
S
NH
Q3c
OH


2728
CMe
O
Q1d
a bond
H
a bond
NH
S
a bond
Q3a
OH


2729
CMe
O
Q1d
a bond
H
a bond
NH
S
a bond
Q3b
OH


2730
CMe
O
Q1d
a bond
H
a bond
NH
S
a bond
Q3c
OH


2731
CMe
O
Q1d
a bond
H
a bond
NH
O
NH
Q3a
OH


2732
CMe
O
Q1d
a bond
H
a bond
NH
O
NH
Q3b
OH


2733
CMe
O
Q1d
a bond
H
a bond
NH
O
NH
Q3c
OH


2734
CMe
O
Q1d
a bond
H
a bond
NH
O
a bond
Q3a
OH


2735
CMe
O
Q1d
a bond
H
a bond
NH
O
a bond
Q3b
OH


2736
CMe
O
Q1d
a bond
H
a bond
NH
O
a bond
Q3c
OH


2737
CMe
O
Q1e
a bond
Me
a bond
NH
S
NH
Q3a
OH


2738
CMe
O
Q1e
a bond
Me
a bond
NH
S
NH
Q3b
OH


2739
CMe
O
Q1e
a bond
Me
a bond
NH
S
NH
Q3c
OH


2740
CMe
O
Q1e
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2741
CMe
O
Q1e
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2742
CMe
O
Q1e
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2743
CMe
O
Q1e
a bond
Me
a bond
NH
O
NH
Q3a
OH


2744
CMe
O
Q1e
a bond
Me
a bond
NH
O
NH
Q3b
OH


2745
CMe
O
Q1e
a bond
Me
a bond
NH
O
NH
Q3c
OH


2746
CMe
O
Q1e
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2747
CMe
O
Q1e
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2748
CMe
O
Q1e
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2749
CMe
O
Q1e
a bond
H
a bond
NH
S
NH
Q3a
OH


2750
CMe
O
Q1e
a bond
H
a bond
NH
S
NH
Q3b
OH


2751
CMe
O
Q1e
a bond
H
a bond
NH
S
NH
Q3c
OH


2752
CMe
O
Q1e
a bond
H
a bond
NH
S
a bond
Q3a
OH


2753
CMe
O
Q1e
a bond
H
a bond
NH
S
a bond
Q3b
OH


2754
CMe
O
Q1e
a bond
H
a bond
NH
S
a bond
Q3c
OH


2755
CMe
O
Q1e
a bond
H
a bond
NH
O
NH
Q3a
OH


2756
CMe
O
Q1e
a bond
H
a bond
NH
O
NH
Q3b
OH


2757
CMe
O
Q1e
a bond
H
a bond
NH
O
NH
Q3c
OH


2758
CMe
O
Q1e
a bond
H
a bond
NH
O
a bond
Q3a
OH


2759
CMe
O
Q1e
a bond
H
a bond
NH
O
a bond
Q3b
OH


2760
CMe
O
Q1e
a bond
H
a bond
NH
O
a bond
Q3c
OH


2761
CMe
O
Q1f
a bond
Me
a bond
NH
S
NH
Q3a
OH


2762
CMe
O
Q1f
a bond
Me
a bond
NH
S
NH
Q3b
OH


2763
CMe
O
Q1f
a bond
Me
a bond
NH
S
NH
Q3c
OH


2764
CMe
O
Q1f
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2765
CMe
O
Q1f
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2766
CMe
O
Q1f
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2767
CMe
O
Q1f
a bond
Me
a bond
NH
O
NH
Q3a
OH


2768
CMe
O
Q1f
a bond
Me
a bond
NH
O
NH
Q3b
OH


2769
CMe
O
Q1f
a bond
Me
a bond
NH
O
NH
Q3c
OH


2770
CMe
O
Q1f
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2771
CMe
O
Q1f
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2772
CMe
O
Q1f
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2773
CMe
O
Q1f
a bond
H
a bond
NH
S
NH
Q3a
OH


2774
CMe
O
Q1f
a bond
H
a bond
NH
S
NH
Q3b
OH


2775
CMe
O
Q1f
a bond
H
a bond
NH
S
NH
Q3c
OH


2776
CMe
O
Q1f
a bond
H
a bond
NH
S
a bond
Q3a
OH


2777
CMe
O
Q1f
a bond
H
a bond
NH
S
a bond
Q3b
OH


2778
CMe
O
Q1f
a bond
H
a bond
NH
S
a bond
Q3c
OH


2779
CMe
O
Q1f
a bond
H
a bond
NH
O
NH
Q3a
OH


2780
CMe
O
Q1f
a bond
H
a bond
NH
O
NH
Q3b
OH


2781
CMe
O
Q1f
a bond
H
a bond
NH
O
NH
Q3c
OH


2782
CMe
O
Q1f
a bond
H
a bond
NH
O
a bond
Q3a
OH


2783
CMe
O
Q1f
a bond
H
a bond
NH
O
a bond
Q3b
OH


2784
CMe
O
Q1f
a bond
H
a bond
NH
O
a bond
Q3c
OH


2785
CMe
O
Q1g
a bond
Me
a bond
NH
S
NH
Q3a
OH


2786
CMe
O
Q1g
a bond
Me
a bond
NH
S
NH
Q3b
OH


2787
CMe
O
Q1g
a bond
Me
a bond
NH
S
NH
Q3c
OH


2788
CMe
O
Q1g
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2789
CMe
O
Q1g
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2790
CMe
O
Q1g
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2791
CMe
O
Q1g
a bond
Me
a bond
NH
O
NH
Q3a
OH


2792
CMe
O
Q1g
a bond
Me
a bond
NH
O
NH
Q3b
OH


2793
CMe
O
Q1g
a bond
Me
a bond
NH
O
NH
Q3c
OH


2794
CMe
O
Q1g
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2795
CMe
O
Q1g
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2796
CMe
O
Q1g
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2797
CMe
O
Q1g
a bond
H
a bond
NH
S
NH
Q3a
OH


2798
CMe
O
Q1g
a bond
H
a bond
NH
S
NH
Q3b
OH


2799
CMe
O
Q1g
a bond
H
a bond
NH
S
NH
Q3c
OH


2800
CMe
O
Q1g
a bond
H
a bond
NH
S
a bond
Q3a
OH


2801
CMe
O
Q1g
a bond
H
a bond
NH
S
a bond
Q3b
OH


2802
CMe
O
Q1g
a bond
H
a bond
NH
S
a bond
Q3c
OH


2803
CMe
O
Q1g
a bond
H
a bond
NH
O
NH
Q3a
OH


2804
CMe
O
Q1g
a bond
H
a bond
NH
O
NH
Q3b
OH


2805
CMe
O
Q1g
a bond
H
a bond
NH
O
NH
Q3c
OH


2806
CMe
O
Q1g
a bond
H
a bond
NH
O
a bond
Q3a
OH


2807
CMe
O
Q1g
a bond
H
a bond
NH
O
a bond
Q3b
OH


2808
CMe
O
Q1g
a bond
H
a bond
NH
O
a bond
Q3c
OH


2809
CMe
O
Q1h
a bond
Me
a bond
NH
S
NH
Q3a
OH


2810
CMe
O
Q1h
a bond
Me
a bond
NH
S
NH
Q3b
OH


2811
CMe
O
Q1h
a bond
Me
a bond
NH
S
NH
Q3c
OH


2812
CMe
O
Q1h
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2813
CMe
O
Q1h
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2814
CMe
O
Q1h
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2815
CMe
O
Q1h
a bond
Me
a bond
NH
O
NH
Q3a
OH


2816
CMe
O
Q1h
a bond
Me
a bond
NH
O
NH
Q3b
OH


2817
CMe
O
Q1h
a bond
Me
a bond
NH
O
NH
Q3c
OH


2818
CMe
O
Q1h
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2819
CMe
O
Q1h
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2820
CMe
O
Q1h
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2821
CMe
O
Q1h
a bond
H
a bond
NH
S
NH
Q3a
OH


2822
CMe
O
Q1h
a bond
H
a bond
NH
S
NH
Q3b
OH


2823
CMe
O
Q1h
a bond
H
a bond
NH
S
NH
Q3c
OH


2824
CMe
O
Q1h
a bond
H
a bond
NH
S
a bond
Q3a
OH


2825
CMe
O
Q1h
a bond
H
a bond
NH
S
a bond
Q3b
OH


2826
CMe
O
Q1h
a bond
H
a bond
NH
S
a bond
Q3c
OH


2827
CMe
O
Q1h
a bond
H
a bond
NH
O
NH
Q3a
OH


2828
CMe
O
Q1h
a bond
H
a bond
NH
O
NH
Q3b
OH


2829
CMe
O
Q1h
a bond
H
a bond
NH
O
NH
Q3c
OH


2830
CMe
O
Q1h
a bond
H
a bond
NH
O
a bond
Q3a
OH


2831
CMe
O
Q1h
a bond
H
a bond
NH
O
a bond
Q3b
OH


2832
CMe
O
Q1h
a bond
H
a bond
NH
O
a bond
Q3c
OH


2833
CMe
O
Q1i
a bond
Me
a bond
NH
S
NH
Q3a
OH


2834
CMe
O
Q1i
a bond
Me
a bond
NH
S
NH
Q3b
OH


2835
CMe
O
Q1i
a bond
Me
a bond
NH
S
NH
Q3c
OH


2836
CMe
O
Q1i
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2837
CMe
O
Q1i
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2838
CMe
O
Q1i
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2839
CMe
O
Q1i
a bond
Me
a bond
NH
O
NH
Q3a
OH


2840
CMe
O
Q1i
a bond
Me
a bond
NH
O
NH
Q3b
OH


2841
CMe
O
Q1i
a bond
Me
a bond
NH
O
NH
Q3c
OH


2842
CMe
O
Q1i
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2843
CMe
O
Q1i
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2844
CMe
O
Q1i
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2845
CMe
O
Q1i
a bond
H
a bond
NH
S
NH
Q3a
OH


2846
CMe
O
Q1i
a bond
H
a bond
NH
S
NH
Q3b
OH


2847
CMe
O
Q1i
a bond
H
a bond
NH
S
NH
Q3c
OH


2848
CMe
O
Q1i
a bond
H
a bond
NH
S
a bond
Q3a
OH


2849
CMe
O
Q1i
a bond
H
a bond
NH
S
a bond
Q3b
OH


2850
CMe
O
Q1i
a bond
H
a bond
NH
S
a bond
Q3c
OH


2851
CMe
O
Q1i
a bond
H
a bond
NH
O
NH
Q3a
OH


2852
CMe
O
Q1i
a bond
H
a bond
NH
O
NH
Q3b
OH


2853
CMe
O
Q1i
a bond
H
a bond
NH
O
NH
Q3c
OH


2854
CMe
O
Q1i
a bond
H
a bond
NH
O
a bond
Q3a
OH


2855
CMe
O
Q1i
a bond
H
a bond
NH
O
a bond
Q3b
OH


2856
CMe
O
Q1i
a bond
H
a bond
NH
O
a bond
Q3c
OH


2857
CMe
O
Q1j
a bond
Me
a bond
NH
S
NH
Q3a
OH


2858
CMe
O
Q1j
a bond
Me
a bond
NH
S
NH
Q3b
OH


2859
CMe
O
Q1j
a bond
Me
a bond
NH
S
NH
Q3c
OH


2860
CMe
O
Q1j
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2861
CMe
O
Q1j
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2862
CMe
O
Q1j
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2863
CMe
O
Q1j
a bond
Me
a bond
NH
O
NH
Q3a
OH


2864
CMe
O
Q1j
a bond
Me
a bond
NH
O
NH
Q3b
OH


2865
CMe
O
Q1j
a bond
Me
a bond
NH
O
NH
Q3c
OH


2866
CMe
O
Q1j
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2867
CMe
O
Q1j
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2868
CMe
O
Q1j
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2869
CMe
O
Q1j
a bond
H
a bond
NH
S
NH
Q3a
OH


2870
CMe
O
Q1j
a bond
H
a bond
NH
S
NH
Q3b
OH


2871
CMe
O
Q1j
a bond
H
a bond
NH
S
NH
Q3c
OH


2872
CMe
O
Q1j
a bond
H
a bond
NH
S
a bond
Q3a
OH


2873
CMe
O
Q1j
a bond
H
a bond
NH
S
a bond
Q3b
OH


2874
CMe
O
Q1j
a bond
H
a bond
NH
S
a bond
Q3c
OH


2875
CMe
O
Q1j
a bond
H
a bond
NH
O
NH
Q3a
OH


2876
CMe
O
Q1j
a bond
H
a bond
NH
O
NH
Q3b
OH


2877
CMe
O
Q1j
a bond
H
a bond
NH
O
NH
Q3c
OH


2878
CMe
O
Q1j
a bond
H
a bond
NH
O
a bond
Q3a
OH


2879
CMe
O
Q1j
a bond
H
a bond
NH
O
a bond
Q3b
OH


2880
CMe
O
Q1j
a bond
H
a bond
NH
O
a bond
Q3c
OH


2881
N
NMe
Q1k
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2882
N
NMe
Q1k
a bond
Me
a bond
NH
O
a bond
Q3d
OH


2883
N
NMe
Q1k
a bond
Me
a bond
NH
O
a bond
Q3e
OH


2884
N
NMe
Q1k
a bond
Me
a bond
NH
O
a bond
Q3f
OH


2885
N
NMe
Q1k
a bond
Me
a bond
NH
O
NH
Q3a
OH


2886
N
NMe
Q1k
a bond
Me
a bond
NH
O
NH
Q3d
OH


2887
N
NMe
Q1k
a bond
Me
a bond
NH
O
NH
Q3e
OH


2888
N
NMe
Q1k
a bond
Me
a bond
NH
O
NH
Q3f
OH


2889
N
NMe
Q1k
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2890
N
NMe
Q1k
a bond
Me
a bond
NH
S
a bond
Q3d
OH


2891
N
NMe
Q1k
a bond
Me
a bond
NH
S
a bond
Q3e
OH


2892
N
NMe
Q1k
a bond
Me
a bond
NH
S
a bond
Q3f
OH


2893
N
NMe
Q1k
a bond
Me
a bond
NH
S
NH
Q3a
OH


2894
N
NMe
Q1k
a bond
Me
a bond
NH
S
NH
Q3d
OH


2895
N
NMe
Q1k
a bond
Me
a bond
NH
S
NH
Q3e
OH


2896
N
NMe
Q1k
a bond
Me
a bond
NH
S
NH
Q3f
OH


2897
N
NMe
Q1l
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2898
N
NMe
Q1l
a bond
Me
a bond
NH
O
a bond
Q3d
OH


2899
N
NMe
Q1l
a bond
Me
a bond
NH
O
a bond
Q3e
OH


2900
N
NMe
Q1l
a bond
Me
a bond
NH
O
a bond
Q3f
OH


2901
N
NMe
Q1l
a bond
Me
a bond
NH
O
NH
Q3a
OH


2902
N
NMe
Q1l
a bond
Me
a bond
NH
O
NH
Q3d
OH


2903
N
NMe
Q1l
a bond
Me
a bond
NH
O
NH
Q3e
OH


2904
N
NMe
Q1l
a bond
Me
a bond
NH
O
NH
Q3f
OH


2905
N
NMe
Q1l
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2906
N
NMe
Q1l
a bond
Me
a bond
NH
S
a bond
Q3d
OH


2907
N
NMe
Q1l
a bond
Me
a bond
NH
S
a bond
Q3e
OH


2908
N
NMe
Q1l
a bond
Me
a bond
NH
S
a bond
Q3f
OH


2909
N
NMe
Q1l
a bond
Me
a bond
NH
S
NH
Q3a
OH


2910
N
NMe
Q1l
a bond
Me
a bond
NH
S
NH
Q3d
OH


2911
N
NMe
Q1l
a bond
Me
a bond
NH
S
NH
Q3e
OH


2912
N
NMe
Q1l
a bond
Me
a bond
NH
S
NH
Q3f
OH


2913
N
NMe
Q1m
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2914
N
NMe
Q1m
a bond
Me
a bond
NH
O
a bond
Q3d
OH


2915
N
NMe
Q1m
a bond
Me
a bond
NH
O
a bond
Q3e
OH


2916
N
NMe
Q1m
a bond
Me
a bond
NH
O
a bond
Q3f
OH


2917
N
NMe
Q1m
a bond
Me
a bond
NH
O
NH
Q3a
OH


2918
N
NMe
Q1m
a bond
Me
a bond
NH
O
NH
Q3d
OH


2919
N
NMe
Q1m
a bond
Me
a bond
NH
O
NH
Q3e
OH


2920
N
NMe
Q1m
a bond
Me
a bond
NH
O
NH
Q3f
OH


2921
N
NMe
Q1m
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2922
N
NMe
Q1m
a bond
Me
a bond
NH
S
a bond
Q3d
OH


2923
N
NMe
Q1m
a bond
Me
a bond
NH
S
a bond
Q3e
OH


2924
N
NMe
Q1m
a bond
Me
a bond
NH
S
a bond
Q3f
OH


2925
N
NMe
Q1m
a bond
Me
a bond
NH
S
NH
Q3a
OH


2926
N
NMe
Q1m
a bond
Me
a bond
NH
S
NH
Q3d
OH


2927
N
NMe
Q1m
a bond
Me
a bond
NH
S
NH
Q3e
OH


2928
N
NMe
Q1m
a bond
Me
a bond
NH
S
NH
Q3f
OH


2929
N
NMe
Q1n
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2930
N
NMe
Q1n
a bond
Me
a bond
NH
O
a bond
Q3d
OH


2931
N
NMe
Q1n
a bond
Me
a bond
NH
O
a bond
Q3e
OH


2932
N
NMe
Q1n
a bond
Me
a bond
NH
O
a bond
Q3f
OH


2933
N
NMe
Q1n
a bond
Me
a bond
NH
O
NH
Q3a
OH


2934
N
NMe
Q1n
a bond
Me
a bond
NH
O
NH
Q3d
OH


2935
N
NMe
Q1n
a bond
Me
a bond
NH
O
NH
Q3e
OH


2936
N
NMe
Q1n
a bond
Me
a bond
NH
O
NH
Q3f
OH


2937
N
NMe
Q1n
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2938
N
NMe
Q1n
a bond
Me
a bond
NH
S
a bond
Q3d
OH


2939
N
NMe
Q1n
a bond
Me
a bond
NH
S
a bond
Q3e
OH


2940
N
NMe
Q1n
a bond
Me
a bond
NH
S
a bond
Q3f
OH


2941
N
NMe
Q1n
a bond
Me
a bond
NH
S
NH
Q3a
OH


2942
N
NMe
Q1n
a bond
Me
a bond
NH
S
NH
Q3d
OH


2943
N
NMe
Q1n
a bond
Me
a bond
NH
S
NH
Q3e
OH


2944
N
NMe
Q1n
a bond
Me
a bond
NH
S
NH
Q3f
OH


2945
N
NEt
Q1k
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2946
N
NEt
Q1k
a bond
Me
a bond
NH
O
a bond
Q3d
OH


2947
N
NEt
Q1k
a bond
Me
a bond
NH
O
a bond
Q3e
OH


2948
N
NEt
Q1k
a bond
Me
a bond
NH
O
a bond
Q3f
OH


2949
N
NEt
Q1k
a bond
Me
a bond
NH
O
NH
Q3a
OH


2950
N
NEt
Q1k
a bond
Me
a bond
NH
O
NH
Q3d
OH


2951
N
NEt
Q1k
a bond
Me
a bond
NH
O
NH
Q3e
OH


2952
N
NEt
Q1k
a bond
Me
a bond
NH
O
NH
Q3f
OH


2953
N
NEt
Q1k
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2954
N
NEt
Q1k
a bond
Me
a bond
NH
S
a bond
Q3d
OH


2955
N
NEt
Q1k
a bond
Me
a bond
NH
S
a bond
Q3e
OH


2956
N
NEt
Q1k
a bond
Me
a bond
NH
S
a bond
Q3f
OH


2957
N
NEt
Q1k
a bond
Me
a bond
NH
S
NH
Q3a
OH


2958
N
NEt
Q1k
a bond
Me
a bond
NH
S
NH
Q3d
OH


2959
N
NEt
Q1k
a bond
Me
a bond
NH
S
NH
Q3e
OH


2960
N
NEt
Q1k
a bond
Me
a bond
NH
S
NH
Q3f
OH


2961
N
NEt
Q1l
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2962
N
NEt
Q1l
a bond
Me
a bond
NH
O
a bond
Q3d
OH


2963
N
NEt
Q1l
a bond
Me
a bond
NH
O
a bond
Q3e
OH


2964
N
NEt
Q1l
a bond
Me
a bond
NH
O
a bond
Q3f
OH


2965
N
NEt
Q1l
a bond
Me
a bond
NH
O
NH
Q3a
OH


2966
N
NEt
Q1l
a bond
Me
a bond
NH
O
NH
Q3d
OH


2967
N
NEt
Q1l
a bond
Me
a bond
NH
O
NH
Q3e
OH


2968
N
NEt
Q1l
a bond
Me
a bond
NH
O
NH
Q3f
OH


2969
N
NEt
Q1l
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2970
N
NEt
Q1l
a bond
Me
a bond
NH
S
a bond
Q3d
OH


2971
N
NEt
Q1l
a bond
Me
a bond
NH
S
a bond
Q3e
OH


2972
N
NEt
Q1l
a bond
Me
a bond
NH
S
a bond
Q3f
OH


2973
N
NEt
Q1l
a bond
Me
a bond
NH
S
NH
Q3a
OH


2974
N
NEt
Q1l
a bond
Me
a bond
NH
S
NH
Q3d
OH


2975
N
NEt
Q1l
a bond
Me
a bond
NH
S
NH
Q3e
OH


2976
N
NEt
Q1l
a bond
Me
a bond
NH
S
NH
Q3f
OH


2977
N
NEt
Q1m
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2978
N
NEt
Q1m
a bond
Me
a bond
NH
O
a bond
Q3d
OH


2979
N
NEt
Q1m
a bond
Me
a bond
NH
O
a bond
Q3e
OH


2980
N
NEt
Q1m
a bond
Me
a bond
NH
O
a bond
Q3f
OH


2981
N
NEt
Q1m
a bond
Me
a bond
NH
O
NH
Q3a
OH


2982
N
NEt
Q1m
a bond
Me
a bond
NH
O
NH
Q3d
OH


2983
N
NEt
Q1m
a bond
Me
a bond
NH
O
NH
Q3e
OH


2984
N
NEt
Q1m
a bond
Me
a bond
NH
O
NH
Q3f
OH


2985
N
NEt
Q1m
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2986
N
NEt
Q1m
a bond
Me
a bond
NH
S
a bond
Q3d
OH


2987
N
NEt
Q1m
a bond
Me
a bond
NH
S
a bond
Q3e
OH


2988
N
NEt
Q1m
a bond
Me
a bond
NH
S
a bond
Q3f
OH


2989
N
NEt
Q1m
a bond
Me
a bond
NH
S
NH
Q3a
OH


2990
N
NEt
Q1m
a bond
Me
a bond
NH
S
NH
Q3d
OH


2991
N
NEt
Q1m
a bond
Me
a bond
NH
S
NH
Q3e
OH


2992
N
NEt
Q1m
a bond
Me
a bond
NH
S
NH
Q3f
OH


2993
N
NEt
Q1n
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2994
N
NEt
Q1n
a bond
Me
a bond
NH
O
a bond
Q3d
OH


2995
N
NEt
Q1n
a bond
Me
a bond
NH
O
a bond
Q3e
OH


2996
N
NEt
Q1n
a bond
Me
a bond
NH
O
a bond
Q3f
OH


2997
N
NEt
Q1n
a bond
Me
a bond
NH
O
NH
Q3a
OH


2998
N
NEt
Q1n
a bond
Me
a bond
NH
O
NH
Q3d
OH


2999
N
NEt
Q1n
a bond
Me
a bond
NH
O
NH
Q3e
OH


3000
N
NEt
Q1n
a bond
Me
a bond
NH
O
NH
Q3f
OH


3001
N
NEt
Q1n
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3002
N
NEt
Q1n
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3003
N
NEt
Q1n
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3004
N
NEt
Q1n
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3005
N
NEt
Q1n
a bond
Me
a bond
NH
S
NH
Q3a
OH


3006
N
NEt
Q1n
a bond
Me
a bond
NH
S
NH
Q3d
OH


3007
N
NEt
Q1n
a bond
Me
a bond
NH
S
NH
Q3e
OH


3008
N
NEt
Q1n
a bond
Me
a bond
NH
S
NH
Q3f
OH


3009
N
S
Q1k
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3010
N
S
Q1k
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3011
N
S
Q1k
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3012
N
S
Q1k
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3013
N
S
Q1k
a bond
Me
a bond
NH
O
NH
Q3a
OH


3014
N
S
Q1k
a bond
Me
a bond
NH
O
NH
Q3d
OH


3015
N
S
Q1k
a bond
Me
a bond
NH
O
NH
Q3e
OH


3016
N
S
Q1k
a bond
Me
a bond
NH
O
NH
Q3f
OH


3017
N
S
Q1k
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3018
N
S
Q1k
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3019
N
S
Q1k
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3020
N
S
Q1k
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3021
N
S
Q1k
a bond
Me
a bond
NH
S
NH
Q3a
OH


3022
N
S
Q1k
a bond
Me
a bond
NH
S
NH
Q3d
OH


3023
N
S
Q1k
a bond
Me
a bond
NH
S
NH
Q3e
OH


3024
N
S
Q1k
a bond
Me
a bond
NH
S
NH
Q3f
OH


3025
N
S
Q1l
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3026
N
S
Q1l
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3027
N
S
Q1l
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3028
N
S
Q1l
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3029
N
S
Q1l
a bond
Me
a bond
NH
O
NH
Q3a
OH


3030
N
S
Q1l
a bond
Me
a bond
NH
O
NH
Q3d
OH


3031
N
S
Q1l
a bond
Me
a bond
NH
O
NH
Q3e
OH


3032
N
S
Q1l
a bond
Me
a bond
NH
O
NH
Q3f
OH


3033
N
S
Q1l
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3034
N
S
Q1l
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3035
N
S
Q1l
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3036
N
S
Q1l
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3037
N
S
Q1l
a bond
Me
a bond
NH
S
NH
Q3a
OH


3038
N
S
Q1l
a bond
Me
a bond
NH
S
NH
Q3d
OH


3039
N
S
Q1l
a bond
Me
a bond
NH
S
NH
Q3e
OH


3040
N
S
Q1l
a bond
Me
a bond
NH
S
NH
Q3f
OH


3041
N
S
Q1m
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3042
N
S
Q1m
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3043
N
S
Q1m
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3044
N
S
Q1m
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3045
N
S
Q1m
a bond
Me
a bond
NH
O
NH
Q3a
OH


3046
N
S
Q1m
a bond
Me
a bond
NH
O
NH
Q3d
OH


3047
N
S
Q1m
a bond
Me
a bond
NH
O
NH
Q3e
OH


3048
N
S
Q1m
a bond
Me
a bond
NH
O
NH
Q3f
OH


3049
N
S
Q1m
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3050
N
S
Q1m
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3051
N
S
Q1m
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3052
N
S
Q1m
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3053
N
S
Q1m
a bond
Me
a bond
NH
S
NH
Q3a
OH


3054
N
S
Q1m
a bond
Me
a bond
NH
S
NH
Q3d
OH


3055
N
S
Q1m
a bond
Me
a bond
NH
S
NH
Q3e
OH


3056
N
S
Q1m
a bond
Me
a bond
NH
S
NH
Q3f
OH


3057
N
S
Q1n
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3058
N
S
Q1n
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3059
N
S
Q1n
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3060
N
S
Q1n
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3061
N
S
Q1n
a bond
Me
a bond
NH
O
NH
Q3a
OH


3062
N
S
Q1n
a bond
Me
a bond
NH
O
NH
Q3d
OH


3063
N
S
Q1n
a bond
Me
a bond
NH
O
NH
Q3e
OH


3064
N
S
Q1n
a bond
Me
a bond
NH
O
NH
Q3f
OH


3065
N
S
Q1n
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3066
N
S
Q1n
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3067
N
S
Q1n
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3068
N
S
Q1n
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3069
N
S
Q1n
a bond
Me
a bond
NH
S
NH
Q3a
OH


3070
N
S
Q1n
a bond
Me
a bond
NH
S
NH
Q3d
OH


3071
N
S
Q1n
a bond
Me
a bond
NH
S
NH
Q3e
OH


3072
N
S
Q1n
a bond
Me
a bond
NH
S
NH
Q3f
OH


3073
N
O
Q1k
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3074
N
O
Q1k
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3075
N
O
Q1k
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3076
N
O
Q1k
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3077
N
O
Q1k
a bond
Me
a bond
NH
O
NH
Q3a
OH


3078
N
O
Q1k
a bond
Me
a bond
NH
O
NH
Q3d
OH


3079
N
O
Q1k
a bond
Me
a bond
NH
O
NH
Q3e
OH


3080
N
O
Q1k
a bond
Me
a bond
NH
O
NH
Q3f
OH


3081
N
O
Q1k
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3082
N
O
Q1k
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3083
N
O
Q1k
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3084
N
O
Q1k
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3085
N
O
Q1k
a bond
Me
a bond
NH
S
NH
Q3a
OH


3086
N
O
Q1k
a bond
Me
a bond
NH
S
NH
Q3d
OH


3087
N
O
Q1k
a bond
Me
a bond
NH
S
NH
Q3e
OH


3088
N
O
Q1k
a bond
Me
a bond
NH
S
NH
Q3f
OH


3089
N
O
Q1l
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3090
N
O
Q1l
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3091
N
O
Q1l
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3092
N
O
Q1l
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3093
N
O
Q1l
a bond
Me
a bond
NH
O
NH
Q3a
OH


3094
N
O
Q1l
a bond
Me
a bond
NH
O
NH
Q3d
OH


3095
N
O
Q1l
a bond
Me
a bond
NH
O
NH
Q3e
OH


3096
N
O
Q1l
a bond
Me
a bond
NH
O
NH
Q3f
OH


3097
N
O
Q1l
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3098
N
O
Q1l
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3099
N
O
Q1l
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3100
N
O
Q1l
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3101
N
O
Q1l
a bond
Me
a bond
NH
S
NH
Q3a
OH


3102
N
O
Q1l
a bond
Me
a bond
NH
S
NH
Q3d
OH


3103
N
O
Q1l
a bond
Me
a bond
NH
S
NH
Q3e
OH


3104
N
O
Q1l
a bond
Me
a bond
NH
S
NH
Q3f
OH


3105
N
O
Q1m
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3106
N
O
Q1m
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3107
N
O
Q1m
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3108
N
O
Q1m
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3109
N
O
Q1m
a bond
Me
a bond
NH
O
NH
Q3a
OH


3110
N
O
Q1m
a bond
Me
a bond
NH
O
NH
Q3d
OH


3111
N
O
Q1m
a bond
Me
a bond
NH
O
NH
Q3e
OH


3112
N
O
Q1m
a bond
Me
a bond
NH
O
NH
Q3f
OH


3113
N
O
Q1m
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3114
N
O
Q1m
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3115
N
O
Q1m
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3116
N
O
Q1m
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3117
N
O
Q1m
a bond
Me
a bond
NH
S
NH
Q3a
OH


3118
N
O
Q1m
a bond
Me
a bond
NH
S
NH
Q3d
OH


3119
N
O
Q1m
a bond
Me
a bond
NH
S
NH
Q3e
OH


3120
N
O
Q1m
a bond
Me
a bond
NH
S
NH
Q3f
OH


3121
N
O
Q1n
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3122
N
O
Q1n
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3123
N
O
Q1n
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3124
N
O
Q1n
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3125
N
O
Q1n
a bond
Me
a bond
NH
O
NH
Q3a
OH


3126
N
O
Q1n
a bond
Me
a bond
NH
O
NH
Q3d
OH


3127
N
O
Q1n
a bond
Me
a bond
NH
O
NH
Q3e
OH


3128
N
O
Q1n
a bond
Me
a bond
NH
O
NH
Q3f
OH


3129
N
O
Q1n
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3130
N
O
Q1n
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3131
N
O
Q1n
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3132
N
O
Q1n
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3133
N
O
Q1n
a bond
Me
a bond
NH
S
NH
Q3a
OH


3134
N
O
Q1n
a bond
Me
a bond
NH
S
NH
Q3d
OH


3135
N
O
Q1n
a bond
Me
a bond
NH
S
NH
Q3e
OH


3136
N
O
Q1n
a bond
Me
a bond
NH
S
NH
Q3f
OH


3137
CH
NMe
Q1k
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3138
CH
NMe
Q1k
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3139
CH
NMe
Q1k
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3140
CH
NMe
Q1k
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3141
CH
NMe
Q1k
a bond
Me
a bond
NH
O
NH
Q3a
OH


3142
CH
NMe
Q1k
a bond
Me
a bond
NH
O
NH
Q3d
OH


3143
CH
NMe
Q1k
a bond
Me
a bond
NH
O
NH
Q3e
OH


3144
CH
NMe
Q1k
a bond
Me
a bond
NH
O
NH
Q3f
OH


3145
CH
NMe
Q1k
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3146
CH
NMe
Q1k
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3147
CH
NMe
Q1k
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3148
CH
NMe
Q1k
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3149
CH
NMe
Q1k
a bond
Me
a bond
NH
S
NH
Q3a
OH


3150
CH
NMe
Q1k
a bond
Me
a bond
NH
S
NH
Q3d
OH


3151
CH
NMe
Q1k
a bond
Me
a bond
NH
S
NH
Q3e
OH


3152
CH
NMe
Q1k
a bond
Me
a bond
NH
S
NH
Q3f
OH


3153
CH
NMe
Q1l
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3154
CH
NMe
Q1l
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3155
CH
NMe
Q1l
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3156
CH
NMe
Q1l
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3157
CH
NMe
Q1l
a bond
Me
a bond
NH
O
NH
Q3a
OH


3158
CH
NMe
Q1l
a bond
Me
a bond
NH
O
NH
Q3d
OH


3159
CH
NMe
Q1l
a bond
Me
a bond
NH
O
NH
Q3e
OH


3160
CH
NMe
Q1l
a bond
Me
a bond
NH
O
NH
Q3f
OH


3161
CH
NMe
Q1l
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3162
CH
NMe
Q1l
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3163
CH
NMe
Q1l
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3164
CH
NMe
Q1l
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3165
CH
NMe
Q1l
a bond
Me
a bond
NH
S
NH
Q3a
OH


3166
CH
NMe
Q1l
a bond
Me
a bond
NH
S
NH
Q3d
OH


3167
CH
NMe
Q1l
a bond
Me
a bond
NH
S
NH
Q3e
OH


3168
CH
NMe
Q1l
a bond
Me
a bond
NH
S
NH
Q3f
OH


3169
CH
NMe
Q1m
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3170
CH
NMe
Q1m
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3171
CH
NMe
Q1m
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3172
CH
NMe
Q1m
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3173
CH
NMe
Q1m
a bond
Me
a bond
NH
O
NH
Q3a
OH


3174
CH
NMe
Q1m
a bond
Me
a bond
NH
O
NH
Q3d
OH


3175
CH
NMe
Q1m
a bond
Me
a bond
NH
O
NH
Q3e
OH


3176
CH
NMe
Q1m
a bond
Me
a bond
NH
O
NH
Q3f
OH


3177
CH
NMe
Q1m
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3178
CH
NMe
Q1m
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3179
CH
NMe
Q1m
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3180
CH
NMe
Q1m
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3181
CH
NMe
Q1m
a bond
Me
a bond
NH
S
NH
Q3a
OH


3182
CH
NMe
Q1m
a bond
Me
a bond
NH
S
NH
Q3d
OH


3183
CH
NMe
Q1m
a bond
Me
a bond
NH
S
NH
Q3e
OH


3184
CH
NMe
Q1m
a bond
Me
a bond
NH
S
NH
Q3f
OH


3185
CH
NMe
Q1n
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3186
CH
NMe
Q1n
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3187
CH
NMe
Q1n
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3188
CH
NMe
Q1n
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3189
CH
NMe
Q1n
a bond
Me
a bond
NH
O
NH
Q3a
OH


3190
CH
NMe
Q1n
a bond
Me
a bond
NH
O
NH
Q3d
OH


3191
CH
NMe
Q1n
a bond
Me
a bond
NH
O
NH
Q3e
OH


3192
CH
NMe
Q1n
a bond
Me
a bond
NH
O
NH
Q3f
OH


3193
CH
NMe
Q1n
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3194
CH
NMe
Q1n
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3195
CH
NMe
Q1n
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3196
CH
NMe
Q1n
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3197
CH
NMe
Q1n
a bond
Me
a bond
NH
S
NH
Q3a
OH


3198
CH
NMe
Q1n
a bond
Me
a bond
NH
S
NH
Q3d
OH


3199
CH
NMe
Q1n
a bond
Me
a bond
NH
S
NH
Q3e
OH


3200
CH
NMe
Q1n
a bond
Me
a bond
NH
S
NH
Q3f
OH


3201
CH
NEt
Q1k
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3202
CH
NEt
Q1k
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3203
CH
NEt
Q1k
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3204
CH
NEt
Q1k
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3205
CH
NEt
Q1k
a bond
Me
a bond
NH
O
NH
Q3a
OH


3206
CH
NEt
Q1k
a bond
Me
a bond
NH
O
NH
Q3d
OH


3207
CH
NEt
Q1k
a bond
Me
a bond
NH
O
NH
Q3e
OH


3208
CH
NEt
Q1k
a bond
Me
a bond
NH
O
NH
Q3f
OH


3209
CH
NEt
Q1k
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3210
CH
NEt
Q1k
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3211
CH
NEt
Q1k
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3212
CH
NEt
Q1k
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3213
CH
NEt
Q1k
a bond
Me
a bond
NH
S
NH
Q3a
OH


3214
CH
NEt
Q1k
a bond
Me
a bond
NH
S
NH
Q3d
OH


3215
CH
NEt
Q1k
a bond
Me
a bond
NH
S
NH
Q3e
OH


3216
CH
NEt
Q1k
a bond
Me
a bond
NH
S
NH
Q3f
OH


3217
CH
NEt
Q1l
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3218
CH
NEt
Q1l
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3219
CH
NEt
Q1l
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3220
CH
NEt
Q1l
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3221
CH
NEt
Q1l
a bond
Me
a bond
NH
O
NH
Q3a
OH


3222
CH
NEt
Q1l
a bond
Me
a bond
NH
O
NH
Q3d
OH


3223
CH
NEt
Q1l
a bond
Me
a bond
NH
O
NH
Q3e
OH


3224
CH
NEt
Q1l
a bond
Me
a bond
NH
O
NH
Q3f
OH


3225
CH
NEt
Q1l
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3226
CH
NEt
Q1l
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3227
CH
NEt
Q1l
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3228
CH
NEt
Q1l
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3229
CH
NEt
Q1l
a bond
Me
a bond
NH
S
NH
Q3a
OH


3230
CH
NEt
Q1l
a bond
Me
a bond
NH
S
NH
Q3d
OH


3231
CH
NEt
Q1l
a bond
Me
a bond
NH
S
NH
Q3e
OH


3232
CH
NEt
Q1l
a bond
Me
a bond
NH
S
NH
Q3f
OH


3233
CH
NEt
Q1m
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3234
CH
NEt
Q1m
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3235
CH
NEt
Q1m
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3236
CH
NEt
Q1m
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3237
CH
NEt
Q1m
a bond
Me
a bond
NH
O
NH
Q3a
OH


3238
CH
NEt
Q1m
a bond
Me
a bond
NH
O
NH
Q3d
OH


3239
CH
NEt
Q1m
a bond
Me
a bond
NH
O
NH
Q3e
OH


3240
CH
NEt
Q1m
a bond
Me
a bond
NH
O
NH
Q3f
OH


3241
CH
NEt
Q1m
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3242
CH
NEt
Q1m
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3243
CH
NEt
Q1m
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3244
CH
NEt
Q1m
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3245
CH
NEt
Q1m
a bond
Me
a bond
NH
S
NH
Q3a
OH


3246
CH
NEt
Q1m
a bond
Me
a bond
NH
S
NH
Q3d
OH


3247
CH
NEt
Q1m
a bond
Me
a bond
NH
S
NH
Q3e
OH


3248
CH
NEt
Q1m
a bond
Me
a bond
NH
S
NH
Q3f
OH


3249
CH
NEt
Q1n
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3250
CH
NEt
Q1n
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3251
CH
NEt
Q1n
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3252
CH
NEt
Q1n
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3253
CH
NEt
Q1n
a bond
Me
a bond
NH
O
NH
Q3a
OH


3254
CH
NEt
Q1n
a bond
Me
a bond
NH
O
NH
Q3d
OH


3255
CH
NEt
Q1n
a bond
Me
a bond
NH
O
NH
Q3e
OH


3256
CH
NEt
Q1n
a bond
Me
a bond
NH
O
NH
Q3f
OH


3257
CH
NEt
Q1n
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3258
CH
NEt
Q1n
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3259
CH
NEt
Q1n
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3260
CH
NEt
Q1n
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3261
CH
NEt
Q1n
a bond
Me
a bond
NH
S
NH
Q3a
OH


3262
CH
NEt
Q1n
a bond
Me
a bond
NH
S
NH
Q3d
OH


3263
CH
NEt
Q1n
a bond
Me
a bond
NH
S
NH
Q3e
OH


3264
CH
NEt
Q1n
a bond
Me
a bond
NH
S
NH
Q3f
OH


3265
CH
S
Q1k
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3266
CH
S
Q1k
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3267
CH
S
Q1k
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3268
CH
S
Q1k
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3269
CH
S
Q1k
a bond
Me
a bond
NH
O
NH
Q3a
OH


3270
CH
S
Q1k
a bond
Me
a bond
NH
O
NH
Q3d
OH


3271
CH
S
Q1k
a bond
Me
a bond
NH
O
NH
Q3e
OH


3272
CH
S
Q1k
a bond
Me
a bond
NH
O
NH
Q3f
OH


3273
CH
S
Q1k
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3274
CH
S
Q1k
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3275
CH
S
Q1k
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3276
CH
S
Q1k
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3277
CH
S
Q1k
a bond
Me
a bond
NH
S
NH
Q3a
OH


3278
CH
S
Q1k
a bond
Me
a bond
NH
S
NH
Q3d
OH


3279
CH
S
Q1k
a bond
Me
a bond
NH
S
NH
Q3e
OH


3280
CH
S
Q1k
a bond
Me
a bond
NH
S
NH
Q3f
OH


3281
CH
S
Q1l
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3282
CH
S
Q1l
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3283
CH
S
Q1l
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3284
CH
S
Q1l
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3285
CH
S
Q1l
a bond
Me
a bond
NH
O
NH
Q3a
OH


3286
CH
S
Q1l
a bond
Me
a bond
NH
O
NH
Q3d
OH


3287
CH
S
Q1l
a bond
Me
a bond
NH
O
NH
Q3e
OH


3288
CH
S
Q1l
a bond
Me
a bond
NH
O
NH
Q3f
OH


3289
CH
S
Q1l
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3290
CH
S
Q1l
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3291
CH
S
Q1l
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3292
CH
S
Q1l
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3293
CH
S
Q1l
a bond
Me
a bond
NH
S
NH
Q3a
OH


3294
CH
S
Q1l
a bond
Me
a bond
NH
S
NH
Q3d
OH


3295
CH
S
Q1l
a bond
Me
a bond
NH
S
NH
Q3e
OH


3296
CH
S
Q1l
a bond
Me
a bond
NH
S
NH
Q3f
OH


3297
CH
S
Q1m
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3298
CH
S
Q1m
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3299
CH
S
Q1m
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3300
CH
S
Q1m
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3301
CH
S
Q1m
a bond
Me
a bond
NH
O
NH
Q3a
OH


3302
CH
S
Q1m
a bond
Me
a bond
NH
O
NH
Q3d
OH


3303
CH
S
Q1m
a bond
Me
a bond
NH
O
NH
Q3e
OH


3304
CH
S
Q1m
a bond
Me
a bond
NH
O
NH
Q3f
OH


3305
CH
S
Q1m
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3306
CH
S
Q1m
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3307
CH
S
Q1m
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3308
CH
S
Q1m
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3309
CH
S
Q1m
a bond
Me
a bond
NH
S
NH
Q3a
OH


3310
CH
S
Q1m
a bond
Me
a bond
NH
S
NH
Q3d
OH


3311
CH
S
Q1m
a bond
Me
a bond
NH
S
NH
Q3e
OH


3312
CH
S
Q1m
a bond
Me
a bond
NH
S
NH
Q3f
OH


3313
CH
S
Q1n
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3314
CH
S
Q1n
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3315
CH
S
Q1n
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3316
CH
S
Q1n
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3317
CH
S
Q1n
a bond
Me
a bond
NH
O
NH
Q3a
OH


3318
CH
S
Q1n
a bond
Me
a bond
NH
O
NH
Q3d
OH


3319
CH
S
Q1n
a bond
Me
a bond
NH
O
NH
Q3e
OH


3320
CH
S
Q1n
a bond
Me
a bond
NH
O
NH
Q3f
OH


3321
CH
S
Q1n
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3322
CH
S
Q1n
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3323
CH
S
Q1n
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3324
CH
S
Q1n
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3325
CH
S
Q1n
a bond
Me
a bond
NH
S
NH
Q3a
OH


3326
CH
S
Q1n
a bond
Me
a bond
NH
S
NH
Q3d
OH


3327
CH
S
Q1n
a bond
Me
a bond
NH
S
NH
Q3e
OH


3328
CH
S
Q1n
a bond
Me
a bond
NH
S
NH
Q3f
OH


3329
CH
O
Q1k
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3330
CH
O
Q1k
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3331
CH
O
Q1k
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3332
CH
O
Q1k
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3333
CH
O
Q1k
a bond
Me
a bond
NH
O
NH
Q3a
OH


3334
CH
O
Q1k
a bond
Me
a bond
NH
O
NH
Q3d
OH


3335
CH
O
Q1k
a bond
Me
a bond
NH
O
NH
Q3e
OH


3336
CH
O
Q1k
a bond
Me
a bond
NH
O
NH
Q3f
OH


3337
CH
O
Q1k
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3338
CH
O
Q1k
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3339
CH
O
Q1k
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3340
CH
O
Q1k
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3341
CH
O
Q1k
a bond
Me
a bond
NH
S
NH
Q3a
OH


3342
CH
O
Q1k
a bond
Me
a bond
NH
S
NH
Q3d
OH


3343
CH
O
Q1k
a bond
Me
a bond
NH
S
NH
Q3e
OH


3344
CH
O
Q1k
a bond
Me
a bond
NH
S
NH
Q3f
OH


3345
CH
O
Q1l
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3346
CH
O
Q1l
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3347
CH
O
Q1l
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3348
CH
O
Q1l
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3349
CH
O
Q1l
a bond
Me
a bond
NH
O
NH
Q3a
OH


3350
CH
O
Q1l
a bond
Me
a bond
NH
O
NH
Q3d
OH


3351
CH
O
Q1l
a bond
Me
a bond
NH
O
NH
Q3e
OH


3352
CH
O
Q1l
a bond
Me
a bond
NH
O
NH
Q3f
OH


3353
CH
O
Q1l
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3354
CH
O
Q1l
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3355
CH
O
Q1l
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3356
CH
O
Q1l
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3357
CH
O
Q1l
a bond
Me
a bond
NH
S
NH
Q3a
OH


3358
CH
O
Q1l
a bond
Me
a bond
NH
S
NH
Q3d
OH


3359
CH
O
Q1l
a bond
Me
a bond
NH
S
NH
Q3e
OH


3360
CH
O
Q1l
a bond
Me
a bond
NH
S
NH
Q3f
OH


3361
CH
O
Q1m
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3362
CH
O
Q1m
a bond
Me
a bond
NH
O
Ga bond
Q3d
OH


3363
CH
O
Q1m
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3364
CH
O
Q1m
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3365
CH
O
Q1m
a bond
Me
a bond
NH
O
NH
Q3a
OH


3366
CH
O
Q1m
a bond
Me
a bond
NH
O
NH
Q3d
OH


3367
CH
O
Q1m
a bond
Me
a bond
NH
O
NH
Q3e
OH


3368
CH
O
Q1m
a bond
Me
a bond
NH
O
NH
Q3f
OH


3369
CH
O
Q1m
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3370
CH
O
Q1m
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3371
CH
O
Q1m
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3372
CH
O
Q1m
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3373
CH
O
Q1m
a bond
Me
a bond
NH
S
NH
Q3a
OH


3374
CH
O
Q1m
a bond
Me
a bond
NH
S
NH
Q3d
OH


3375
CH
O
Q1m
a bond
Me
a bond
NH
S
NH
Q3e
OH


3376
CH
O
Q1m
a bond
Me
a bond
NH
S
NH
Q3f
OH


3377
CH
O
Q1n
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3378
CH
O
Q1n
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3379
CH
O
Q1n
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3380
CH
O
Q1n
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3381
CH
O
Q1n
a bond
Me
a bond
NH
O
NH
Q3a
OH


3382
CH
O
Q1n
a bond
Me
a bond
NH
O
NH
Q3d
OH


3383
CH
O
Q1n
a bond
Me
a bond
NH
O
NH
Q3e
OH


3384
CH
O
Q1n
a bond
Me
a bond
NH
O
NH
Q3f
OH


3385
CH
O
Q1n
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3386
CH
O
Q1n
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3387
CH
O
Q1n
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3388
CH
O
Q1n
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3389
CH
O
Q1n
a bond
Me
a bond
NH
S
NH
Q3a
OH


3390
CH
O
Q1n
a bond
Me
a bond
NH
S
NH
Q3d
OH


3391
CH
O
Q1n
a bond
Me
a bond
NH
S
NH
Q3e
OH


3392
CH
O
Q1n
a bond
Me
a bond
NH
S
NH
Q3f
OH


3393
CMe
NMe
Q1k
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3394
CMe
NMe
Q1k
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3395
CMe
NMe
Q1k
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3396
CMe
NMe
Q1k
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3397
CMe
NMe
Q1k
a bond
Me
a bond
NH
O
NH
Q3a
OH


3398
CMe
NMe
Q1k
a bond
Me
a bond
NH
O
NH
Q3d
OH


3399
CMe
NMe
Q1k
a bond
Me
a bond
NH
O
NH
Q3e
OH


3400
CMe
NMe
Q1k
a bond
Me
a bond
NH
O
NH
Q3f
OH


3401
CMe
NMe
Q1k
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3402
CMe
NMe
Q1k
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3403
CMe
NMe
Q1k
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3404
CMe
NMe
Q1k
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3405
CMe
NMe
Q1k
a bond
Me
a bond
NH
S
NH
Q3a
OH


3406
CMe
NMe
Q1k
a bond
Me
a bond
NH
S
NH
Q3d
OH


3407
CMe
NMe
Q1k
a bond
Me
a bond
NH
S
NH
Q3e
OH


3408
CMe
NMe
Q1k
a bond
Me
a bond
NH
S
NH
Q3f
OH


3409
CMe
NMe
Q1l
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3410
CMe
NMe
Q1l
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3411
CMe
NMe
Q1l
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3412
CMe
NMe
Q1l
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3413
CMe
NMe
Q1l
a bond
Me
a bond
NH
O
NH
Q3a
OH


3414
CMe
NMe
Q1l
a bond
Me
a bond
NH
O
NH
Q3d
OH


3415
CMe
NMe
Q1l
a bond
Me
a bond
NH
O
NH
Q3e
OH


3416
CMe
NMe
Q1l
a bond
Me
a bond
NH
O
NH
Q3f
OH


3417
CMe
NMe
Q1l
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3418
CMe
NMe
Q1l
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3419
CMe
NMe
Q1l
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3420
CMe
NMe
Q1l
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3421
CMe
NMe
Q1l
a bond
Me
a bond
NH
S
NH
Q3a
OH


3422
CMe
NMe
Q1l
a bond
Me
a bond
NH
S
NH
Q3d
OH


3423
CMe
NMe
Q1l
a bond
Me
a bond
NH
S
NH
Q3e
OH


3424
CMe
NMe
Q1l
a bond
Me
a bond
NH
S
NH
Q3f
OH


3425
CMe
NMe
Q1m
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3426
CMe
NMe
Q1m
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3427
CMe
NMe
Q1m
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3428
CMe
NMe
Q1m
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3429
CMe
NMe
Q1m
a bond
Me
a bond
NH
O
NH
Q3a
OH


3430
CMe
NMe
Q1m
a bond
Me
a bond
NH
O
NH
Q3d
OH


3431
CMe
NMe
Q1m
a bond
Me
a bond
NH
O
NH
Q3e
OH


3432
CMe
NMe
Q1m
a bond
Me
a bond
NH
O
NH
Q3f
OH


3433
CMe
NMe
Q1m
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3434
CMe
NMe
Q1m
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3435
CMe
NMe
Q1m
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3436
CMe
NMe
Q1m
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3437
CMe
NMe
Q1m
a bond
Me
a bond
NH
S
NH
Q3a
OH


3438
CMe
NMe
Q1m
a bond
Me
a bond
NH
S
NH
Q3d
OH


3439
CMe
NMe
Q1m
a bond
Me
a bond
NH
S
NH
Q3e
OH


3440
CMe
NMe
Q1m
a bond
Me
a bond
NH
S
NH
Q3f
OH


3441
CMe
NMe
Q1n
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3442
CMe
NMe
Q1n
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3443
CMe
NMe
Q1n
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3444
CMe
NMe
Q1n
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3445
CMe
NMe
Q1n
a bond
Me
a bond
NH
O
NH
Q3a
OH


3446
CMe
NMe
Q1n
a bond
Me
a bond
NH
O
NH
Q3d
OH


3447
CMe
NMe
Q1n
a bond
Me
a bond
NH
O
NH
Q3e
OH


3448
CMe
NMe
Q1n
a bond
Me
a bond
NH
O
NH
Q3f
OH


3449
CMe
NMe
Q1n
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3450
CMe
NMe
Q1n
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3451
CMe
NMe
Q1n
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3452
CMe
NMe
Q1n
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3453
CMe
NMe
Q1n
a bond
Me
a bond
NH
S
NH
Q3a
OH


3454
CMe
NMe
Q1n
a bond
Me
a bond
NH
S
NH
Q3d
OH


3455
CMe
NMe
Q1n
a bond
Me
a bond
NH
S
NH
Q3e
OH


3456
CMe
NMe
Q1n
a bond
Me
a bond
NH
S
NH
Q3f
OH


3457
CMe
NEt
Q1k
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3458
CMe
NEt
Q1k
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3459
CMe
NEt
Q1k
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3460
CMe
NEt
Q1k
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3461
CMe
NEt
Q1k
a bond
Me
a bond
NH
O
NH
Q3a
OH


3462
CMe
NEt
Q1k
a bond
Me
a bond
NH
O
NH
Q3d
OH


3463
CMe
NEt
Q1k
a bond
Me
a bond
NH
O
NH
Q3e
OH


3464
CMe
NEt
Q1k
a bond
Me
a bond
NH
O
NH
Q3f
OH


3465
CMe
NEt
Q1k
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3466
CMe
NEt
Q1k
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3467
CMe
NEt
Q1k
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3468
CMe
NEt
Q1k
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3469
CMe
NEt
Q1k
a bond
Me
a bond
NH
S
NH
Q3a
OH


3470
CMe
NEt
Q1k
a bond
Me
a bond
NH
S
NH
Q3d
OH


3471
CMe
NEt
Q1k
a bond
Me
a bond
NH
S
NH
Q3e
OH


3472
CMe
NEt
Q1k
a bond
Me
a bond
NH
S
NH
Q3f
OH


3473
CMe
NEt
Q1l
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3474
CMe
NEt
Q1l
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3475
CMe
NEt
Q1l
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3476
CMe
NEt
Q1l
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3477
CMe
NEt
Q1l
a bond
Me
a bond
NH
O
NH
Q3a
OH


3478
CMe
NEt
Q1l
a bond
Me
a bond
NH
O
NH
Q3d
OH


3479
CMe
NEt
Q1l
a bond
Me
a bond
NH
O
NH
Q3e
OH


3480
CMe
NEt
Q1l
a bond
Me
a bond
NH
O
NH
Q3f
OH


3481
CMe
NEt
Q1l
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3482
CMe
NEt
Q1l
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3483
CMe
NEt
Q1l
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3484
CMe
NEt
Q1l
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3485
CMe
NEt
Q1l
a bond
Me
a bond
NH
S
NH
Q3a
OH


3486
CMe
NEt
Q1l
a bond
Me
a bond
NH
S
NH
Q3d
OH


3487
CMe
NEt
Q1l
a bond
Me
a bond
NH
S
NH
Q3e
OH


3488
CMe
NEt
Q1l
a bond
Me
a bond
NH
S
NH
Q3f
OH


3489
CMe
NEt
Q1m
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3490
CMe
NEt
Q1m
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3491
CMe
NEt
Q1m
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3492
CMe
NEt
Q1m
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3493
CMe
NEt
Q1m
a bond
Me
a bond
NH
O
NH
Q3a
OH


3494
CMe
NEt
Q1m
a bond
Me
a bond
NH
O
NH
Q3d
OH


3495
CMe
NEt
Q1m
a bond
Me
a bond
NH
O
NH
Q3e
OH


3496
CMe
NEt
Q1m
a bond
Me
a bond
NH
O
NH
Q3f
OH


3497
CMe
NEt
Q1m
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3498
CMe
NEt
Q1m
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3499
CMe
NEt
Q1m
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3500
CMe
NEt
Q1m
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3501
CMe
NEt
Q1m
a bond
Me
a bond
NH
S
NH
Q3a
OH


3502
CMe
NEt
Q1m
a bond
Me
a bond
NH
S
NH
Q3d
OH


3503
CMe
NEt
Q1m
a bond
Me
a bond
NH
S
NH
Q3e
OH


3504
CMe
NEt
Q1m
a bond
Me
a bond
NH
S
NH
Q3f
OH


3505
CMe
NEt
Q1n
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3506
CMe
NEt
Q1n
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3507
CMe
NEt
Q1n
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3508
CMe
NEt
Q1n
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3509
CMe
NEt
Q1n
a bond
Me
a bond
NH
O
NH
Q3a
OH


3510
CMe
NEt
Q1n
a bond
Me
a bond
NH
O
NH
Q3d
OH


3511
CMe
NEt
Q1n
a bond
Me
a bond
NH
O
NH
Q3e
OH


3512
CMe
NEt
Q1n
a bond
Me
a bond
NH
O
NH
Q3f
OH


3513
CMe
NEt
Q1n
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3514
CMe
NEt
Q1n
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3515
CMe
NEt
Q1n
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3516
CMe
NEt
Q1n
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3517
CMe
NEt
Q1n
a bond
Me
a bond
NH
S
NH
Q3a
OH


3518
CMe
NEt
Q1n
a bond
Me
a bond
NH
S
NH
Q3d
OH


3519
CMe
NEt
Q1n
a bond
Me
a bond
NH
S
NH
Q3e
OH


3520
CMe
NEt
Q1n
a bond
Me
a bond
NH
S
NH
Q3f
OH


3521
CMe
S
Q1k
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3522
CMe
S
Q1k
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3523
CMe
S
Q1k
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3524
CMe
S
Q1k
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3525
CMe
S
Q1k
a bond
Me
a bond
NH
O
NH
Q3a
OH


3526
CMe
S
Q1k
a bond
Me
a bond
NH
O
NH
Q3d
OH


3527
CMe
S
Q1k
a bond
Me
a bond
NH
O
NH
Q3e
OH


3528
CMe
S
Q1k
a bond
Me
a bond
NH
O
NH
Q3f
OH


3529
CMe
S
Q1k
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3530
CMe
S
Q1k
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3531
CMe
S
Q1k
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3532
CMe
S
Q1k
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3533
CMe
S
Q1k
a bond
Me
a bond
NH
S
NH
Q3a
OH


3534
CMe
S
Q1k
a bond
Me
a bond
NH
S
NH
Q3d
OH


3535
CMe
S
Q1k
a bond
Me
a bond
NH
S
NH
Q3e
OH


3536
CMe
S
Q1k
a bond
Me
a bond
NH
S
NH
Q3f
OH


3537
CMe
S
Q1l
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3538
CMe
S
Q1l
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3539
CMe
S
Q1l
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3540
CMe
S
Q1l
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3541
CMe
S
Q1l
a bond
Me
a bond
NH
O
NH
Q3a
OH


3542
CMe
S
Q1l
a bond
Me
a bond
NH
O
NH
Q3d
OH


3543
CMe
S
Q1l
a bond
Me
a bond
NH
O
NH
Q3e
OH


3544
CMe
S
Q1l
a bond
Me
a bond
NH
O
NH
Q3f
OH


3545
CMe
S
Q1l
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3546
CMe
S
Q1l
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3547
CMe
S
Q1l
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3548
CMe
S
Q1l
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3549
CMe
S
Q1l
a bond
Me
a bond
NH
S
NH
Q3a
OH


3550
CMe
S
Q1l
a bond
Me
a bond
NH
S
NH
Q3d
OH


3551
CMe
S
Q1l
a bond
Me
a bond
NH
S
NH
Q3e
OH


3552
CMe
S
Q1l
a bond
Me
a bond
NH
S
NH
Q3f
OH


3553
CMe
S
Q1m
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3554
CMe
S
Q1m
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3555
CMe
S
Q1m
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3556
CMe
S
Q1m
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3557
CMe
S
Q1m
a bond
Me
a bond
NH
O
NH
Q3a
OH


3558
CMe
S
Q1m
a bond
Me
a bond
NH
O
NH
Q3d
OH


3559
CMe
S
Q1m
a bond
Me
a bond
NH
O
NH
Q3e
OH


3560
CMe
S
Q1m
a bond
Me
a bond
NH
O
NH
Q3f
OH


3561
CMe
S
Q1m
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3562
CMe
S
Q1m
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3563
CMe
S
Q1m
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3564
CMe
S
Q1m
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3565
CMe
S
Q1m
a bond
Me
a bond
NH
S
NH
Q3a
OH


3566
CMe
S
Q1m
a bond
Me
a bond
NH
S
NH
Q3d
OH


3567
CMe
S
Q1m
a bond
Me
a bond
NH
S
NH
Q3e
OH


3568
CMe
S
Q1m
a bond
Me
a bond
NH
S
NH
Q3f
OH


3569
CMe
S
Q1n
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3570
CMe
S
Q1n
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3571
CMe
S
Q1n
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3572
CMe
S
Q1n
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3573
CMe
S
Q1n
a bond
Me
a bond
NH
O
NH
Q3a
OH


3574
CMe
S
Q1n
a bond
Me
a bond
NH
O
NH
Q3d
OH


3575
CMe
S
Q1n
a bond
Me
a bond
NH
O
NH
Q3e
OH


3576
CMe
S
Q1n
a bond
Me
a bond
NH
O
NH
Q3f
OH


3577
CMe
S
Q1n
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3578
CMe
S
Q1n
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3579
CMe
S
Q1n
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3580
CMe
S
Q1n
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3581
CMe
S
Q1n
a bond
Me
a bond
NH
S
NH
Q3a
OH


3582
CMe
S
Q1n
a bond
Me
a bond
NH
S
NH
Q3d
OH


3583
CMe
S
Q1n
a bond
Me
a bond
NH
S
NH
Q3e
OH


3584
CMe
S
Q1n
a bond
Me
a bond
NH
S
NH
Q3f
OH


3585
CMe
O
Q1k
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3586
CMe
O
Q1k
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3587
CMe
O
Q1k
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3588
CMe
O
Q1k
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3589
CMe
O
Q1k
a bond
Me
a bond
NH
O
NH
Q3a
OH


3590
CMe
O
Q1k
a bond
Me
a bond
NH
O
NH
Q3d
OH


3591
CMe
O
Q1k
a bond
Me
a bond
NH
O
NH
Q3e
OH


3592
CMe
O
Q1k
a bond
Me
a bond
NH
O
NH
Q3f
OH


3593
CMe
O
Q1k
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3594
CMe
O
Q1k
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3595
CMe
O
Q1k
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3596
CMe
O
Q1k
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3597
CMe
O
Q1k
a bond
Me
a bond
NH
S
NH
Q3a
OH


3598
CMe
O
Q1k
a bond
Me
a bond
NH
S
NH
Q3d
OH


3599
CMe
O
Q1k
a bond
Me
a bond
NH
S
NH
Q3e
OH


3600
CMe
O
Q1k
a bond
Me
a bond
NH
S
NH
Q3f
OH


3601
CMe
O
Q1l
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3602
CMe
O
Q1l
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3603
CMe
O
Q1l
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3604
CMe
O
Q1l
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3605
CMe
O
Q1l
a bond
Me
a bond
NH
O
NH
Q3a
OH


3606
CMe
O
Q1l
a bond
Me
a bond
NH
O
NH
Q3d
OH


3607
CMe
O
Q1l
a bond
Me
a bond
NH
O
NH
Q3e
OH


3608
CMe
O
Q1l
a bond
Me
a bond
NH
O
NH
Q3f
OH


3609
CMe
O
Q1l
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3610
CMe
O
Q1l
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3611
CMe
O
Q1l
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3612
CMe
O
Q1l
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3613
CMe
O
Q1l
a bond
Me
a bond
NH
S
NH
Q3a
OH


3614
CMe
O
Q1l
a bond
Me
a bond
NH
S
NH
Q3d
OH


3615
CMe
O
Q1l
a bond
Me
a bond
NH
S
NH
Q3e
OH


3616
CMe
O
Q1l
a bond
Me
a bond
NH
S
NH
Q3f
OH


3617
CMe
O
Q1m
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3618
CMe
O
Q1m
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3619
CMe
O
Q1m
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3620
CMe
O
Q1m
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3621
CMe
O
Q1m
a bond
Me
a bond
NH
O
NH
Q3a
OH


3622
CMe
O
Q1m
a bond
Me
a bond
NH
O
NH
Q3d
OH


3623
CMe
O
Q1m
a bond
Me
a bond
NH
O
NH
Q3e
OH


3624
CMe
O
Q1m
a bond
Me
a bond
NH
O
NH
Q3f
OH


3625
CMe
O
Q1m
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3626
CMe
O
Q1m
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3627
CMe
O
Q1m
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3628
CMe
O
Q1m
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3629
CMe
O
Q1m
a bond
Me
a bond
NH
S
NH
Q3a
OH


3630
CMe
O
Q1m
a bond
Me
a bond
NH
S
NH
Q3d
OH


3631
CMe
O
Q1m
a bond
Me
a bond
NH
S
NH
Q3e
OH


3632
CMe
O
Q1m
a bond
Me
a bond
NH
S
NH
Q3f
OH


3633
CMe
O
Q1n
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3634
CMe
O
Q1n
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3635
CMe
O
Q1n
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3636
CMe
O
Q1n
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3637
CMe
O
Q1n
a bond
Me
a bond
NH
O
NH
Q3a
OH


3638
CMe
O
Q1n
a bond
Me
a bond
NH
O
NH
Q3d
OH


3639
CMe
O
Q1n
a bond
Me
a bond
NH
O
NH
Q3e
OH


3640
CMe
O
Q1n
a bond
Me
a bond
NH
O
NH
Q3f
OH


3641
CMe
O
Q1n
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3642
CMe
O
Q1n
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3643
CMe
O
Q1n
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3644
CMe
O
Q1n
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3645
CMe
O
Q1n
a bond
Me
a bond
NH
S
NH
Q3a
OH


3646
CMe
O
Q1n
a bond
Me
a bond
NH
S
NH
Q3d
OH


3647
CMe
O
Q1n
a bond
Me
a bond
NH
S
NH
Q3e
OH


3648
CMe
O
Q1n
a bond
Me
a bond
NH
S
NH
Q3f
OH


3649
N
NMe
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3650
N
NMe
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3651
N
NMe
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3652
N
NMe
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3653
N
NMe
Q1k′
a bond
Me
a bond
NH
O
NH
Q3a
OH


3654
N
NMe
Q1k′
a bond
Me
a bond
NH
O
NH
Q3d
OH


3655
N
NMe
Q1k′
a bond
Me
a bond
NH
O
NH
Q3e
OH


3656
N
NMe
Q1k′
a bond
Me
a bond
NH
O
NH
Q3f
OH


3657
N
NMe
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3658
N
NMe
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3659
N
NMe
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3660
N
NMe
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3661
N
NMe
Q1k′
a bond
Me
a bond
NH
S
NH
Q3a
OH


3662
N
NMe
Q1k′
a bond
Me
a bond
NH
S
NH
Q3d
OH


3663
N
NMe
Q1k′
a bond
Me
a bond
NH
S
NH
Q3e
OH


3664
N
NMe
Q1k′
a bond
Me
a bond
NH
S
NH
Q3f
OH


3665
N
NMe
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3666
N
NMe
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3667
N
NMe
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3668
N
NMe
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3669
N
NMe
Q1l′
a bond
Me
a bond
NH
O
NH
Q3a
OH


3670
N
NMe
Q1l′
a bond
Me
a bond
NH
O
NH
Q3d
OH


3671
N
NMe
Q1l′
a bond
Me
a bond
NH
O
NH
Q3e
OH


3672
N
NMe
Q1l′
a bond
Me
a bond
NH
O
NH
Q3f
OH


3673
N
NMe
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3674
N
NMe
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3675
N
NMe
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3676
N
NMe
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3677
N
NMe
Q1l′
a bond
Me
a bond
NH
S
NH
Q3a
OH


3678
N
NMe
Q1l′
a bond
Me
a bond
NH
S
NH
Q3d
OH


3679
N
NMe
Q1l′
a bond
Me
a bond
NH
S
NH
Q3e
OH


3680
N
NMe
Q1l′
a bond
Me
a bond
NH
S
NH
Q3f
OH


3681
N
NMe
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3682
N
NMe
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3683
N
NMe
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3684
N
NMe
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3685
N
NMe
Q1m′
a bond
Me
a bond
NH
O
NH
Q3a
OH


3686
N
NMe
Q1m′
a bond
Me
a bond
NH
O
NH
Q3d
OH


3687
N
NMe
Q1m′
a bond
Me
a bond
NH
O
NH
Q3e
OH


3688
N
NMe
Q1m′
a bond
Me
a bond
NH
O
NH
Q3f
OH


3689
N
NMe
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3690
N
NMe
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3691
N
NMe
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3692
N
NMe
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3693
N
NMe
Q1m′
a bond
Me
a bond
NH
S
NH
Q3a
OH


3694
N
NMe
Q1m′
a bond
Me
a bond
NH
S
NH
Q3d
OH


3695
N
NMe
Q1m′
a bond
Me
a bond
NH
S
NH
Q3e
OH


3696
N
NMe
Q1m′
a bond
Me
a bond
NH
S
NH
Q3f
OH


3697
N
NMe
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3698
N
NMe
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3699
N
NMe
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3700
N
NMe
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3701
N
NMe
Q1n′
a bond
Me
a bond
NH
O
NH
Q3a
OH


3702
N
NMe
Q1n′
a bond
Me
a bond
NH
O
NH
Q3d
OH


3703
N
NMe
Q1n′
a bond
Me
a bond
NH
O
NH
Q3e
OH


3704
N
NMe
Q1n′
a bond
Me
a bond
NH
O
NH
Q3f
OH


3705
N
NMe
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3706
N
NMe
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3707
N
NMe
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3708
N
NMe
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3709
N
NMe
Q1n′
a bond
Me
a bond
NH
S
NH
Q3a
OH


3710
N
NMe
Q1n′
a bond
Me
a bond
NH
S
NH
Q3d
OH


3711
N
NMe
Q1n′
a bond
Me
a bond
NH
S
NH
Q3e
OH


3712
N
NMe
Q1n′
a bond
Me
a bond
NH
S
NH
Q3f
OH


3713
N
NEt
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3714
N
NEt
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3715
N
NEt
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3716
N
NEt
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3717
N
NEt
Q1k′
a bond
Me
a bond
NH
O
NH
Q3a
OH


3718
N
NEt
Q1k′
a bond
Me
a bond
NH
O
NH
Q3d
OH


3719
N
NEt
Q1k′
a bond
Me
a bond
NH
O
NH
Q3e
OH


3720
N
NEt
Q1k′
a bond
Me
a bond
NH
O
NH
Q3f
OH


3721
N
NEt
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3722
N
NEt
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3723
N
NEt
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3724
N
NEt
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3725
N
NEt
Q1k′
a bond
Me
a bond
NH
S
NH
Q3a
OH


3726
N
NEt
Q1k′
a bond
Me
a bond
NH
S
NH
Q3d
OH


3727
N
NEt
Q1k′
a bond
Me
a bond
NH
S
NH
Q3e
OH


3728
N
NEt
Q1k′
a bond
Me
a bond
NH
S
NH
Q3f
OH


3729
N
NEt
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3730
N
NEt
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3731
N
NEt
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3732
N
NEt
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3733
N
NEt
Q1l′
a bond
Me
a bond
NH
O
NH
Q3a
OH


3734
N
NEt
Q1l′
a bond
Me
a bond
NH
O
NH
Q3d
OH


3735
N
NEt
Q1l′
a bond
Me
a bond
NH
O
NH
Q3e
OH


3736
N
NEt
Q1l′
a bond
Me
a bond
NH
O
NH
Q3f
OH


3737
N
NEt
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3738
N
NEt
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3739
N
NEt
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3740
N
NEt
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3741
N
NEt
Q1l′
a bond
Me
a bond
NH
S
NH
Q3a
OH


3742
N
NEt
Q1l′
a bond
Me
a bond
NH
S
NH
Q3d
OH


3743
N
NEt
Q1l′
a bond
Me
a bond
NH
S
NH
Q3e
OH


3744
N
NEt
Q1l′
a bond
Me
a bond
NH
S
NH
Q3f
OH


3745
N
NEt
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3746
N
NEt
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3747
N
NEt
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3748
N
NEt
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3749
N
NEt
Q1m′
a bond
Me
a bond
NH
O
NH
Q3a
OH


3750
N
NEt
Q1m′
a bond
Me
a bond
NH
O
NH
Q3d
OH


3751
N
NEt
Q1m′
a bond
Me
a bond
NH
O
NH
Q3e
OH


3752
N
NEt
Q1m′
a bond
Me
a bond
NH
O
NH
Q3f
OH


3753
N
NEt
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3754
N
NEt
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3755
N
NEt
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3756
N
NEt
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3757
N
NEt
Q1m′
a bond
Me
a bond
NH
S
NH
Q3a
OH


3758
N
NEt
Q1m′
a bond
Me
a bond
NH
S
NH
Q3d
OH


3759
N
NEt
Q1m′
a bond
Me
a bond
NH
S
NH
Q3e
OH


3760
N
NEt
Q1m′
a bond
Me
a bond
NH
S
NH
Q3f
OH


3761
N
NEt
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3762
N
NEt
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3763
N
NEt
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3764
N
NEt
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3765
N
NEt
Q1n′
a bond
Me
a bond
NH
O
NH
Q3a
OH


3766
N
NEt
Q1n′
a bond
Me
a bond
NH
O
NH
Q3d
OH


3767
N
NEt
Q1n′
a bond
Me
a bond
NH
O
NH
Q3e
OH


3768
N
NEt
Q1n′
a bond
Me
a bond
NH
O
NH
Q3f
OH


3769
N
NEt
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3770
N
NEt
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3771
N
NEt
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3772
N
NEt
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3773
N
NEt
Q1n′
a bond
Me
a bond
NH
S
NH
Q3a
OH


3774
N
NEt
Q1n′
a bond
Me
a bond
NH
S
NH
Q3d
OH


3775
N
NEt
Q1n′
a bond
Me
a bond
NH
S
NH
Q3e
OH


3776
N
NEt
Q1n′
a bond
Me
a bond
NH
S
NH
Q3f
OH


3777
N
S
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3778
N
S
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3779
N
S
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3780
N
S
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3781
N
S
Q1k′
a bond
Me
a bond
NH
O
NH
Q3a
OH


3782
N
S
Q1k′
a bond
Me
a bond
NH
O
NH
Q3d
OH


3783
N
S
Q1k′
a bond
Me
a bond
NH
O
NH
Q3e
OH


3784
N
S
Q1k′
a bond
Me
a bond
NH
O
NH
Q3f
OH


3785
N
S
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3786
N
S
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3787
N
S
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3788
N
S
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3789
N
S
Q1k′
a bond
Me
a bond
NH
S
NH
Q3a
OH


3790
N
S
Q1k′
a bond
Me
a bond
NH
S
NH
Q3d
OH


3791
N
S
Q1k′
a bond
Me
a bond
NH
S
NH
Q3e
OH


3792
N
S
Q1k′
a bond
Me
a bond
NH
S
NH
Q3f
OH


3793
N
S
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3794
N
S
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3795
N
S
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3796
N
S
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3797
N
S
Q1l′
a bond
Me
a bond
NH
O
NH
Q3a
OH


3798
N
S
Q1l′
a bond
Me
a bond
NH
O
NH
Q3d
OH


3799
N
S
Q1l′
a bond
Me
a bond
NH
O
NH
Q3e
OH


3800
N
S
Q1l′
a bond
Me
a bond
NH
O
NH
Q3f
OH


3801
N
S
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3802
N
S
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3803
N
S
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3804
N
S
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3805
N
S
Q1l′
a bond
Me
a bond
NH
S
NH
Q3a
OH


3806
N
S
Q1l′
a bond
Me
a bond
NH
S
NH
Q3d
OH


3807
N
S
Q1l′
a bond
Me
a bond
NH
S
NH
Q3e
OH


3808
N
S
Q1l′
a bond
Me
a bond
NH
S
NH
Q3f
OH


3809
N
S
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3810
N
S
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3811
N
S
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3812
N
S
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3813
N
S
Q1m′
a bond
Me
a bond
NH
O
NH
Q3a
OH


3814
N
S
Q1m′
a bond
Me
a bond
NH
O
NH
Q3d
OH


3815
N
S
Q1m′
a bond
Me
a bond
NH
O
NH
Q3e
OH


3816
N
S
Q1m′
a bond
Me
a bond
NH
O
NH
Q3f
OH


3817
N
S
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3818
N
S
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3819
N
S
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3820
N
S
Q1m′
abdnd
Me
a bond
NH
S
a bond
Q3f
OH


3821
N
S
Q1m′
a bond
Me
a bond
NH
S
NH
Q3a
OH


3822
N
S
Q1m′
a bond
Me
a bond
NH
S
NH
Q3d
OH


3823
N
S
Q1m′
a bond
Me
a bond
NH
S
NH
Q3e
OH


3824
N
S
Q1w′
a bond
Me
a bond
NH
S
NH
Q3f
OH


3825
N
S
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3826
N
S
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3827
N
S
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3828
N
S
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3829
N
S
Q1n′
a bond
Me
a bond
NH
O
NH
Q3a
OH


3830
N
S
Q1n′
a bond
Me
a bond
NH
O
NH
Q3d
OH


3831
N
S
Q1n′
a bond
Me
a bond
NH
O
NH
Q3e
OH


3832
N
S
Q1n′
a bond
Me
a bond
NH
O
NH
Q3f
OH


3833
N
S
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3834
N
S
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3835
N
S
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3836
N
S
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3837
N
S
Q1n′
a bond
Me
a bond
NH
S
NH
Q3a
OH


3838
N
S
Q1n′
a bond
Me
a bond
NH
S
NH
Q3d
OH


3839
N
S
Q1n′
a bond
Me
a bond
NH
S
NH
Q3e
OH


3840
N
S
Q1n′
a bond
Me
a bond
NH
S
NH
Q3f
OH


3841
N
O
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3842
N
O
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3843
N
O
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3844
N
O
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3845
N
O
Q1k′
a bond
Me
a bond
NH
O
NH
Q3a
OH


3846
N
O
Q1k′
a bond
Me
a bond
NH
O
NH
Q3d
OH


3847
N
O
Q1k′
a bond
Me
a bond
NH
O
NH
Q3e
OH


3848
N
O
Q1k′
a bond
Me
a bond
NH
O
NH
Q3f
OH


3849
N
O
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3850
N
O
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3851
N
O
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3852
N
O
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3853
N
O
Q1k′
a bond
Me
a bond
NH
S
NH
Q3a
OH


3854
N
O
Q1k′
a bond
Me
a bond
NH
S
NH
Q3d
OH


3855
N
O
Q1k′
a bond
Me
a bond
NH
S
NH
Q3e
OH


3856
N
O
Q1k′
a bond
Me
a bond
NH
S
NH
Q3f
OH


3857
N
O
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3858
N
O
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3859
N
O
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3860
N
O
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3861
N
O
Q1l′
a bond
Me
a bond
NH
O
NH
Q3a
OH


3862
N
O
Q1l′
a bond
Me
a bond
NH
O
NH
Q3d
OH


3863
N
O
Q1l′
a bond
Me
a bond
NH
O
NH
Q3e
OH


3864
N
O
Q1l′
a bond
Me
a bond
NH
O
NH
Q3f
OH


3865
N
O
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3866
N
O
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3867
N
O
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3868
N
O
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3869
N
O
Q1l′
a bond
Me
a bond
NH
S
NH
Q3a
OH


3870
N
O
Q1l′
a bond
Me
a bond
NH
S
NH
Q3d
OH


3871
N
O
Q1l′
a bond
Me
a bond
NH
S
NH
Q3e
OH


3872
N
O
Q1l′
a bond
Me
a bond
NH
S
NH
Q3f
OH


3873
N
O
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3874
N
O
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3875
N
O
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3876
N
O
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3877
N
O
Q1m′
a bond
Me
a bond
NH
O
NH
Q3a
OH


3878
N
O
Q1m′
a bond
Me
a bond
NH
O
NH
Q3d
OH


3879
N
O
Q1m′
a bond
Me
a bond
NH
O
NH
Q3e
OH


3880
N
O
Q1m′
a bond
Me
a bond
NH
O
NH
Q3f
OH


3881
N
O
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3882
N
O
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3883
N
O
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3884
N
O
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3885
N
O
Q1m′
a bond
Me
a bond
NH
S
NH
Q3a
OH


3886
N
O
Q1m′
a bond
Me
a bond
NH
S
NH
Q3d
OH


3887
N
O
Q1m′
a bond
Me
a bond
NH
S
NH
Q3e
OH


3888
N
O
Q1m′
a bond
Me
a bond
NH
S
NH
Q3f
OH


3889
N
O
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3890
N
O
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3891
N
O
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3892
N
O
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3893
N
O
Q1n′
a bond
Me
a bond
NH
O
NH
Q3a
OH


3894
N
O
Q1n′
a bond
Me
a bond
NH
O
NH
Q3d
OH


3895
N
O
Q1n′
a bond
Me
a bond
NH
O
NH
Q3e
OH


3896
N
O
Q1n′
a bond
Me
a bond
NH
O
NH
Q3f
OH


3897
N
O
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3898
N
O
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3899
N
O
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3900
N
O
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3901
N
O
Q1n′
a bond
Me
a bond
NH
S
NH
Q3a
OH


3902
N
O
Q1n′
a bond
Me
a bond
NH
S
NH
Q3d
OH


3903
N
O
Q1n′
a bond
Me
a bond
NH
S
NH
Q3e
OH


3904
N
O
Q1n′
a bond
Me
a bond
NH
S
NH
Q3f
OH


3905
CH
NMe
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3906
CH
NMe
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3907
CH
NMe
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3908
CH
NMe
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3909
CH
NMe
Q1k′
a bond
Me
a bond
NH
O
NH
Q3a
OH


3910
CH
NMe
Q1k′
a bond
Me
a bond
NH
O
NH
Q3d
OH


3911
CH
NMe
Q1k′
a bond
Me
a bond
NH
O
NH
Q3e
OH


3912
CH
NMe
Q1k′
a bond
Me
a bond
NH
O
NH
Q3f
OH


3913
CH
NMe
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3914
CH
NMe
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3915
CH
NMe
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3916
CH
NMe
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3917
CH
NMe
Q1k′
a bond
Me
a bond
NH
S
NH
Q3a
OH


3918
CH
NMe
Q1k′
a bond
Me
a bond
NH
S
NH
Q3d
OH


3919
CH
NMe
Q1k′
a bond
Me
a bond
NH
S
NH
Q3e
OH


3920
CH
NMe
Q1k′
a bond
Me
a bond
NH
S
NH
Q3f
OH


3921
CH
NMe
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3922
CH
NMe
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3923
CH
NMe
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3924
CH
NMe
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3925
CH
NMe
Q1l′
a bond
Me
a bond
NH
O
NH
Q3a
OH


3926
CH
NMe
Q1l′
a bond
Me
a bond
NH
O
NH
Q3d
OH


3927
CH
NMe
Q1l′
a bond
Me
a bond
NH
O
NH
Q3e
OH


3928
CH
NMe
Q1l′
a bond
Me
a bond
NH
O
NH
Q3f
OH


3929
CH
NMe
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3930
CH
NMe
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3931
CH
NMe
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3932
CH
NMe
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3933
CH
NMe
Q1l′
a bond
Me
a bond
NH
S
NH
Q3a
OH


3934
CH
NMe
Q11′
a bond
Me
a bond
NH
S
NH
Q3d
OH


3935
CH
NMe
Q11′
a bond
Me
a bond
NH
S
NH
Q3e
OH


3936
CH
NMe
Q11′
a bond
Me
a bond
NH
S
NH
Q3f
OH


3937
CH
NMe
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3938
CH
NMe
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3939
CH
NMe
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3940
CH
NMe
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3941
CH
NMe
Q1m′
a bond
Me
a bond
NH
O
NH
Q3a
OH


3942
CH
NMe
Q1m′
a bond
Me
a bond
NH
O
NH
Q3d
OH


3943
CH
NMe
Q1m′
a bond
Me
a bond
NH
O
NH
Q3e
OH


3944
CH
NMe
Q1m′
a bond
Me
a bond
NH
O
NH
Q3f
OH


3945
CH
NMe
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3946
CH
NMe
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3947
CH
NMe
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3948
CH
NMe
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3949
CH
NMe
Q1m′
a bond
Me
a bond
NH
S
NH
Q3a
OH


3950
CH
NMe
Q1m′
a bond
Me
a bond
NH
S
NH
Q3d
OH


3951
CH
NMe
Q1m′
a bond
Me
a bond
NH
S
NH
Q3e
OH


3952
CH
NMe
Q1m′
a bond
Me
a bond
NH
S
NH
Q3f
OH


3953
CH
NMe
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3954
CH
NMe
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3955
CH
NMe
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3956
CH
NMe
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3957
CH
NMe
Q1n′
a bond
Me
a bond
NH
O
NH
Q3a
OH


3958
CH
NMe
Q1n′
a bond
Me
a bond
NH
O
NH
Q3d
OH


3959
CH
NMe
Q1n′
a bond
Me
a bond
NH
O
NH
Q3e
OH


3960
CH
NMe
Q1n′
a bond
Me
a bond
NH
O
NH
Q3f
OH


3961
CH
NMe
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3962
CH
NMe
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3963
CH
NMe
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3964
CH
NMe
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3965
CH
NMe
Q1n′
a bond
Me
a bond
NH
S
NH
Q3a
OH


3966
CH
NMe
Q1n′
a bond
Me
a bond
NH
S
NH
Q3d
OH


3967
CH
NMe
Q1n′
a bond
Me
a bond
NH
S
NH
Q3e
OH


3968
CH
NMe
Q1n′
a bond
Me
a bond
NH
S
NH
Q3f
OH


3969
CH
NEt
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3970
CH
NEt
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3971
CH
NEt
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3972
CH
NEt
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3973
CH
NEt
Q1k′
a bond
Me
a bond
NH
O
NH
Q3a
OH


3974
CH
NEt
Q1k′
a bond
Me
a bond
NH
O
NH
Q3d
OH


3975
CH
NEt
Q1k′
a bond
Me
a bond
NH
O
NH
Q3e
OH


3976
CH
NEt
Q1k′
a bond
Me
a bond
NH
O
NH
Q3f
OH


3977
CH
NEt
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3978
CH
NEt
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3979
CH
NEt
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3980
CH
NEt
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3981
CH
NEt
Q1k′
a bond
Me
a bond
NH
S
NH
Q3a
OH


3982
CH
NEt
Q1k′
a bond
Me
a bond
NH
S
NH
Q3d
OH


3983
CH
NEt
Q1k′
a bond
Me
a bond
NH
S
NH
Q3e
OH


3984
CH
NEt
Q1k′
a bond
Me
a bond
NH
S
NH
Q3f
OH


3985
CH
NEt
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3986
CH
NEt
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3987
CH
NEt
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3988
CH
NEt
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


3989
CH
NEt
Q1l′
a bond
Me
a bond
NH
O
NH
Q3a
OH


3990
CH
NEt
Q1l′
a bond
Me
a bond
NH
O
NH
Q3d
OH


3991
CH
NEt
Q1l′
a bond
Me
a bond
NH
O
NH
Q3e
OH


3992
CH
NEt
Q1l′
a bond
Me
a bond
NH
O
NH
Q3f
OH


3993
CH
NEt
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3994
CH
NEt
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


3995
CH
NEt
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3996
CH
NEt
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


3997
CH
NEt
Q1l′
a bond
Me
a bond
NH
S
NH
Q3a
OH


3998
CH
NEt
Q1l′
a bond
Me
a bond
NH
S
NH
Q3d
OH


3999
CH
NEt
Q1l′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4000
CH
NEt
Q1l′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4001
CH
NEt
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4002
CH
NEt
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4003
CH
NEt
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4004
CH
NEt
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4005
CH
NEt
Q1m′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4006
CH
NEt
Q1m′
a bond
Me
a bond
NH
O
NH
Q3d
OH


4007
CH
NEt
Q1m′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4008
CH
NEt
Q1m′
a bond
Me
a bond
NH
O
NH
Q3f
OH


4009
CH
NEt
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4010
CH
NEt
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4011
CH
NEt
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4012
CH
NEt
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4013
CH
NEt
Q1m′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4014
CH
NEt
Q1m′
a bond
Me
a bond
NH
S
NH
Q3d
OH


4015
CH
NEt
Q1m′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4016
CH
NEt
Q1m′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4017
CH
NEt
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4018
CH
NEt
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4019
CH
NEt
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4020
CH
NEt
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4021
CH
NEt
Q1n′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4022
CH
NEt
Q1n′
a bond
Me
a bond
NH
O
NH
Q3d
OH


4023
CH
NEt
Q1n′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4024
CH
NEt
Q1n′
a bond
Me
a bond
NH
O
NH
Q3f
OH


4025
CH
NEt
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4026
CH
NEt
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4027
CH
NEt
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4028
CH
NEt
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4029
CH
NEt
Q1n′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4030
CH
NEt
Q1n′
a bond
Me
a bond
NH
S
NH
Q3d
OH


4031
CH
NEt
Q1n′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4032
CH
NEt
Q1n′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4033
CH
S
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4034
CH
S
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4035
CH
S
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4036
CH
S
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4037
CH
S
Q1k′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4038
CH
S
Q1k′
a bond
Me
a bond
NH
O
NH
Q3d
OH


4039
CH
S
Q1k′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4040
CH
S
Q1k′
a bond
Me
a bond
NH
O
NH
Q3f
OH


4041
CH
S
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4042
CH
S
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4043
CH
S
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4044
CH
S
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4045
CH
S
Q1k′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4046
CH
S
Q1k′
a bond
Me
a bond
NH
S
NH
Q3d
OH


4047
CH
S
Q1k′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4048
CH
S
Q1k′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4049
CH
S
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4050
CH
S
011′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4051
CH
S
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4052
CH
S
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4053
CH
S
Q1l′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4054
CH
S
Q1l′
a bond
Me
a bond
NH
O
NH
Q3d
OH


4055
CH
S
Q1l′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4056
CH
S
Q1l′
a bond
Me
a bond
NH
O
NH
Q3f
OH


4057
CH
S
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4058
CH
S
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4059
CH
S
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4060
CH
S
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4061
CH
S
Q1l′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4062
CH
S
Q1l′
a bond
Me
a bond
NH
S
NH
Q3d
OH


4063
CH
S
Q1l′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4064
CH
S
Q1l′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4065
CH
S
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4066
CH
S
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4067
CH
S
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4068
CH
S
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4069
CH
S
Q1m′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4070
CH
S
Q1m′
a bond
Me
a bond
NH
O
NH
Q3d
OH


4071
CH
S
Q1m′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4072
CH
S
Q1m′
a bond
Me
a bond
NH
O
NH
Q3f
OH


4073
CH
S
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4074
CH
S
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4075
CH
S
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4076
CH
S
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4077
CH
S
Q1m′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4078
CH
S
Q1m′
a bond
Me
a bond
NH
S
NH
Q3d
OH


4079
CH
S
Q1m′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4080
CH
S
Q1m′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4081
CH
S
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4082
CH
S
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4083
CH
S
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4084
CH
S
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4085
CH
S
Q1n′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4086
CH
S
Q1n′
a bond
Me
a bond
NH
O
NH
Q3d
OH


4087
CH
S
Q1n′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4088
CH
S
Q1n′
a bond
Me
a bond
NH
O
NH
Q3f
OH


4089
CH
S
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4090
CH
S
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4091
CH
S
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4092
CH
S
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4093
CH
S
Q1n′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4094
CH
S
Q1n′
a bond
Me
a bond
NH
S
NH
Q3d
OH


4095
CH
S
Q1n′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4096
CH
S
Q1n′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4097
CH
O
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4098
CH
O
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4099
CH
O
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4100
CH
O
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4101
CH
O
Q1k′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4102
CH
O
Q1k′
a bond
Me
a bond
NH
O
NH
Q3d
OH


4103
CH
O
Q1k′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4104
CH
O
Q1k′
a bond
Me
a bond
NH
O
NH
Q3f
OH


4105
CH
O
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4106
CH
O
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4107
CH
O
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4108
CH
O
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4109
CH
O
Q1k′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4110
CH
O
Q1k′
a bond
Me
a bond
NH
S
NH
Q3d
OH


4111
CH
O
Q1k′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4112
CH
O
Q1k′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4113
CH
O
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4114
CH
O
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4115
CH
O
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4116
CH
O
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4117
CH
O
Q1l′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4118
CH
O
Q1l′
a bond
Me
a bond
NH
O
NH
Q3d
OH


4119
CH
O
Q1l′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4120
CH
O
Q1l′
a bond
Me
a bond
NH
O
NH
Q3f
OH


4121
CH
O
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4122
CH
O
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4123
CH
O
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4124
CH
O
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4125
CH
O
Q1l′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4126
CH
O
Q1l′
a bond
Me
a bond
NH
S
NH
Q3d
OH


4127
CH
O
Q1l′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4128
CH
O
Q1l′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4129
CH
O
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4130
CH
O
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4131
CH
O
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4132
CH
O
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4133
CH
O
Q1m′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4134
CH
O
Q1m′
a bond
Me
a bond
NH
O
NH
Q3d
OH


4135
CH
O
Q1m′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4136
CH
O
Q1m′
a bond
Me
a bond
NH
O
NH
Q3f
OH


4137
CH
O
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4138
CH
O
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4139
CH
O
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4140
CH
O
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4141
CH
O
Q1m′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4142
CH
O
Q1m′
a bond
Me
a bond
NH
S
NH
Q3d
OH


4143
CH
O
Q1m′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4144
CH
O
Q1m′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4145
CH
O
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4146
CH
O
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4147
CH
O
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4148
CH
O
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4149
CH
O
Q1n′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4150
CH
O
Q1n′
a bond
Me
a bond
NH
O
NH
Q3d
OH


4151
CH
O
Q1n′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4152
CH
O
Q1n′
a bond
Me
a bond
NH
O
NH
Q3f
OH


4153
CH
O
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4154
CH
O
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4155
CH
O
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4156
CH
O
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4157
CH
O
Q1n′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4158
CH
O
Q1n′
a bond
Me
a bond
NH
S
NH
Q3d
OH


4159
CH
O
Q1n′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4160
CH
O
Q1n′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4161
CMe
NMe
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4162
CMe
NMe
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4163
CMe
NMe
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4164
CMe
NMe
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4165
CMe
NMe
Q1k′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4166
CMe
NMe
Q1k′
a bond
Me
a bond
NH
O
NH
Q3d
OH


4167
CMe
NMe
Q1k′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4168
CMe
NMe
Q1k′
a bond
Me
a bond
NH
O
NH
Q3f
OH


4169
CMe
NMe
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4170
CMe
NMe
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4171
CMe
NMe
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4172
CMe
NMe
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4173
CMe
NMe
Q1k′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4174
CMe
NMe
Q1k′
a bond
Me
a bond
NH
S
NH
Q3d
OH


4175
CMe
NMe
Q1k′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4176
CMe
NMe
Q1k′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4177
CMe
NMe
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4178
CMe
NMe
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4179
CMe
NMe
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4180
CMe
NMe
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4181
CMe
NMe
Q1l′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4182
CMe
NMe
Q1l′
a bond
Me
a bond
NH
O
NH
Q3d
OH


4183
CMe
NMe
Q1l′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4184
CMe
NMe
Q1l′
a bond
Me
a bond
NH
O
NH
Q3f
OH


4185
CMe
NMe
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4186
CMe
NMe
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4187
CMe
NMe
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4188
CMe
NMe
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4189
CMe
NMe
Q1l′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4190
CMe
NMe
Q1l′
a bond
Me
a bond
NH
S
NH
Q3d
OH


4191
CMe
NMe
Q1l′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4192
CMe
NMe
Q1l′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4193
CMe
NMe
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4194
CMe
NMe
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4195
CMe
NMe
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4196
CMe
NMe
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4197
CMe
NMe
Q1m′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4198
CMe
NMe
Q1m′
a bond
Me
a bond
NH
O
NH
Q3d
OH


4199
CMe
NMe
Q1m′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4200
CMe
NMe
Q1m′
a bond
Me
a bond
NH
O
NH
Q3f
OH


4201
CMe
NMe
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4202
CMe
NMe
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4203
CMe
NMe
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4204
CMe
NMe
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4205
CMe
NMe
Q1m′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4206
CMe
NMe
Q1m′
a bond
Me
a bond
NH
S
NH
Q3d
OH


4207
CMe
NMe
Q1m′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4208
CMe
NMe
Q1m′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4209
CMe
NMe
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4210
CMe
NMe
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4211
CMe
NMe
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4212
CMe
NMe
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4213
CMe
NMe
Q1n′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4214
CMe
NMe
Q1n′
a bond
Me
a bond
NH
O
NH
Q3d
OH


4215
CMe
NMe
Q1n′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4216
CMe
NMe
Q1n′
a bond
Me
a bond
NH
O
NH
Q3f
OH


4217
CMe
NMe
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4218
CMe
NMe
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4219
CMe
NMe
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4220
CMe
NMe
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4221
CMe
NMe
Q1n′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4222
CMe
NMe
Q1n′
a bond
Me
a bond
NH
S
NH
Q3d
OH


4223
CMe
NMe
Q1n′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4224
CMe
NMe
Q1n′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4225
CMe
NEt
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4226
CMe
NEt
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4227
CMe
NEt
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4228
CMe
NEt
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4229
CMe
NEt
Q1k′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4230
CMe
NEt
Q1k′
a bond
Me
a bond
NH
O
NH
Q3d
OH


4231
CMe
NEt
Q1k′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4232
CMe
NEt
Q1k′
a bond
Me
a bond
NH
O
NH
Q3f
OH


4233
CMe
NEt
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4234
CMe
NEt
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4235
CMe
NEt
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4236
CMe
NEt
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4237
CMe
NEt
Q1k′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4238
CMe
NEt
Q1k′
a bond
Me
a bond
NH
S
NH
Q3d
OH


4239
CMe
NEt
Q1k′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4240
CMe
NEt
Q1k′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4241
CMe
NEt
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4242
CMe
NEt
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4243
CMe
NEt
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4244
CMe
NEt
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4245
CMe
NEt
Q1l′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4246
CMe
NEt
Q1l′
a bond
Me
a bond
NH
O
NH
Q3d
OH


4247
CMe
NEt
Q1l′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4248
CMe
NEt
Q1l′
a bond
Me
a bond
NH
O
NH
Q3f
OH


4249
CMe
NEt
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4250
CMe
NEt
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4251
CMe
NEt
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4252
CMe
NEt
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4253
CMe
NEt
Q1l′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4254
CMe
NEt
Q1l′
a bond
Me
a bond
NH
S
NH
Q3d
OH


4255
CMe
NEt
Q1l′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4256
CMe
NEt
Q1l′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4257
CMe
NEt
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4258
CMe
NEt
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4259
CMe
NEt
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4260
CMe
NEt
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4261
CMe
NEt
Q1m′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4262
CMe
NEt
Q1m′
a bond
Me
a bond
NH
O
NH
Q3d
OH


4263
CMe
NEt
Q1m′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4264
CMe
NEt
Q1m′
a bond
Me
a bond
NH
O
NH
Q3f
OH


4265
CMe
NEt
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4266
CMe
NEt
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4267
CMe
NEt
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4268
CMe
NEt
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4269
CMe
NEt
Q1m′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4270
CMe
NEt
Q1m′
a bond
Me
a bond
NH
S
NH
Q3d
OH


4271
CMe
NEt
Q1m′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4272
CMe
NEt
Q1m′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4273
CMe
NEt
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4274
CMe
NEt
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4275
CMe
NEt
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4276
CMe
NEt
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4277
CMe
NEt
Q1n′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4278
CMe
NEt
Q1n′
a bond
Me
a bond
NH
O
NH
Q3d
OH


4279
CMe
NEt
Q1n′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4280
CMe
NEt
Q1n′
a bond
Me
a bond
NH
O
NH
Q3f
OH


4281
CMe
NEt
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4282
CMe
NEt
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4283
CMe
NEt
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4284
CMe
NEt
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4285
CMe
NEt
Q1n′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4286
CMe
NEt
Q1n′
a bond
Me
a bond
NH
S
NH
Q3d
OH


4287
CMe
NEt
Q1n′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4288
CMe
NEt
Q1n′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4289
CMe
S
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4290
CMe
S
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4291
CMe
S
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4292
CMe
S
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4293
CMe
S
Q1k′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4294
CMe
S
Q1k′
a bond
Me
a bond
NH
O
NH
Q3d
OH


4295
CMe
S
Q1k′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4296
CMe
S
Q1k′
a bond
Me
a bond
NH
O
NH
Q3f
OH


4297
CMe
S
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4298
CMe
S
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4299
CMe
S
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4300
CMe
S
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4301
CMe
S
Q1k′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4302
CMe
S
Q1k′
a bond
Me
a bond
NH
S
NH
Q3d
OH


4303
CMe
S
Q1k′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4304
CMe
S
Q1k′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4305
CMe
S
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4306
CMe
S
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4307
CMe
S
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4308
CMe
S
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4309
CMe
S
Q1l′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4310
CMe
S
Q1l′
a bond
Me
a bond
NH
O
NH
Q3d
OH


4311
CMe
S
Q1l′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4312
CMe
S
Q1l′
a bond
Me
a bond
NH
O
NH
Q3f
OH


4313
CMe
S
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4314
CMe
S
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4315
CMe
S
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4316
CMe
S
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4317
CMe
S
Q1l′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4318
CMe
S
Q1l′
a bond
Me
a bond
NH
S
NH
Q3d
OH


4319
CMe
S
Q1l′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4320
CMe
S
Q1l′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4321
CMe
S
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4322
CMe
S
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4323
CMe
S
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4324
CMe
S
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4325
CMe
S
Q1m′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4326
CMe
S
Q1m′
a bond
Me
a bond
NH
O
NH
Q3d
OH


4327
CMe
S
Q1m′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4328
CMe
S
Q1m′
a bond
Me
a bond
NH
O
NH
Q3f
OH


4329
CMe
S
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4330
CMe
S
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4331
CMe
S
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4332
CMe
S
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4333
CMe
S
Q1m′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4334
CMe
S
Q1m′
a bond
Me
a bond
NH
S
NH
Q3d
OH


4335
CMe
S
Q1m′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4336
CMe
S
Q1m′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4337
CMe
S
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4338
CMe
S
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4339
CMe
S
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4340
CMe
S
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4341
CMe
S
Q1n′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4342
CMe
S
Q1n′
a bond
Me
a bond
NH
O
NH
Q3d
OH


4343
CMe
S
Q1n′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4344
CMe
S
Q1n′
a bond
Me
a bond
NH
O
NH
Q3f
OH


4345
CMe
S
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4346
CMe
S
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4347
CMe
S
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4348
CMe
S
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4349
CMe
S
Q1n′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4350
CMe
S
Q1n′
a bond
Me
a bond
NH
S
NH
Q3d
OH


4351
CMe
S
Q1n′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4352
CMe
S
Q1n′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4353
CMe
O
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4354
CMe
O
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4355
CMe
O
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4356
CMe
O
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4357
CMe
O
Q1k′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4358
CMe
O
Q1k′
a bond
Me
a bond
NH
O
NH
Q3d
OH


4359
CMe
O
Q1k′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4360
CMe
O
Q1k′
a bond
Me
a bond
NH
O
NH
Q3f
OH


4361
CMe
O
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4362
CMe
O
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4363
CMe
O
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4364
CMe
O
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4365
CMe
O
Q1k′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4366
CMe
O
Q1k′
a bond
Me
a bond
NH
S
NH
Q3d
OH


4367
CMe
O
Q1k′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4368
CMe
O
Q1k′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4369
CMe
O
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4370
CMe
O
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4371
CMe
O
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4372
CMe
O
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4373
CMe
O
Q1l′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4374
CMe
O
Q1l′
a bond
Me
a bond
NH
O
NH
Q3d
OH


4375
CMe
O
Q1l′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4376
CMe
O
Q1l′
a bond
Me
a bond
NH
O
NH
Q3f
OH


4377
CMe
O
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4378
CMe
O
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4379
CMe
O
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4380
CMe
O
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4381
CMe
O
Q1l′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4382
CMe
O
Q1l′
a bond
Me
a bond
NH
S
NH
Q3d
OH


4383
CMe
O
Q1l′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4384
CMe
O
Q1l′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4385
CMe
O
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4386
CMe
O
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4387
CMe
O
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4388
CMe
O
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4389
CMe
O
Q1m′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4390
CMe
O
Q1m′
a bond
Me
a bond
NH
O
NH
Q3d
OH


4391
CMe
O
Q1m′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4392
CMe
O
Q1m′
a bond
Me
a bond
NH
O
NH
Q3f
OH


4393
CMe
O
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4394
CMe
O
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4395
CMe
O
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4396
CMe
O
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4397
CMe
O
Q1m′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4398
CMe
O
Q1m′
a bond
Me
a bond
NH
S
NH
Q3d
OH


4399
CMe
O
Q1m′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4400
CMe
O
Q1m′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4401
CMe
O
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4402
CMe
O
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4403
CMe
O
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4404
CMe
O
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4405
CMe
O
Q1n′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4406
CMe
O
Q1n′
a bond
Me
a bond
NH
O
NH
Q3d
OH


4407
CMe
O
Q1n′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4408
CMe
O
Q1n′
a bond
Me
a bond
NH
O
NH
Q3f
OH


4409
CMe
O
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4410
CMe
O
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4411
CMe
O
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4412
CMe
O
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4413
CMe
O
Q1n′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4414
CMe
O
Q1n′
a bond
Me
a bond
NH
S
NH
Q3d
OH


4415
CMe
O
Q1n′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4416
CMe
O
Q1n′
a bond
Me
a bond
NH
S
NH
Q3f
OH


4417
N
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4418
N
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4419
N
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4420
N
NMe
Q1a
a bond
Me
a bond
NH
O
NH
Q3d
OH


4421
N
NMe
Q1a
a bond
Me
a bond
NH
O
NH
Q3e
OH


4422
N
NMe
Q1a
a bond
Me
a bond
NH
O
NH
Q3f
OH


4423
N
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4424
N
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4425
N
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4426
N
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3d
OH


4427
N
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3e
OH


4428
N
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3f
OH


4429
N
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4430
N
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4431
N
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4432
N
NMe
Q1b
a bond
Me
a bond
NH
O
NH
Q3d
OH


4433
N
NMe
Q1b
a bond
Me
a bond
NH
O
NH
Q3e
OH


4434
N
NMe
Q1b
a bond
Me
a bond
NH
O
NH
Q3f
OH


4435
N
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4436
N
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4437
N
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4438
N
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3d
OH


4439
N
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3e
OH


4440
N
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3f
OH


4441
N
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4442
N
Nme
Q1c
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4443
N
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4444
N
NMe
Q1c
a bond
Me
a bond
NH
O
NH
Q3d
OH


4445
N
NMe
Q1c
a bond
Me
a bond
NH
O
NH
Q3e
OH


4446
N
NMe
Q1c
a bond
Me
a bond
NH
O
NH
Q3f
OH


4447
N
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4448
N
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4449
N
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4450
N
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3d
OH


4451
N
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3e
OH


4452
N
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3f
OH


4453
N
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4454
N
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4455
N
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4456
N
NEt
Q1a
a bond
Me
a bond
NH
O
NH
Q3d
OH


4457
N
NEt
Q1a
a bond
Me
a bond
NH
O
NH
Q3e
OH


4458
N
NEt
Q1a
a bond
Me
a bond
NH
O
NH
Q3f
OH


4459
N
NEt
Q1a
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4460
N
NEt
Q1a
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4461
N
NEt
Q1a
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4462
N
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3d
OH


4463
N
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3e
OH


4464
N
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3f
OH


4465
N
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4466
N
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4467
N
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4468
N
NEt
Q1b
a bond
Me
a bond
NH
O
NH
Q3d
OH


4469
N
NEt
Q1b
a bond
Me
a bond
NH
O
NH
Q3e
OH


4470
N
NEt
Q1b
a bond
Me
a bond
NH
O
NH
Q3f
OH


4471
N
NEt
Q1b
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4472
N
NEt
Q1b
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4473
N
NEt
Q1b
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4474
N
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3d
OH


4475
N
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3e
OH


4476
N
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3f
OH


4477
N
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4478
N
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4479
N
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4480
N
NEt
Q1c
a bond
Me
a bond
NH
O
NH
Q3d
OH


4481
N
NEt
Q1c
a bond
Me
a bond
NH
O
NH
Q3e
OH


4482
N
NEt
Q1c
a bond
Me
a bond
NH
O
NH
Q3f
OH


4483
N
NEt
Q1c
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4484
N
NEt
Q1c
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4485
N
NEt
Q1c
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4486
N
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3d
OH


4487
N
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3e
OH


4488
N
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3f
OH


4489
N
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4490
N
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4491
N
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4492
N
S
Q1a
a bond
Me
a bond
NH
O
NH
Q3d
OH


4493
N
S
Q1a
a bond
Me
a bond
NH
O
NH
Q3e
OH


4494
N
S
Q1a
a bond
Me
a bond
NH
O
NH
Q3f
OH


4495
N
S
Q1a
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4496
N
S
Q1a
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4497
N
S
Q1a
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4498
N
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3d
OH


4499
N
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3e
OH


4500
N
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3f
OH


4501
N
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4502
N
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4503
N
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4504
N
S
Q1b
a bond
Me
a bond
NH
O
NH
Q3d
OH


4505
N
S
Q1b
a bond
Me
a bond
NH
O
NH
Q3e
OH


4506
N
S
Q1b
a bond
Me
a bond
NH
O
NH
Q3f
OH


4507
N
S
Q1b
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4508
N
S
Q1b
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4509
N
S
Q1b
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4510
N
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3d
OH


4511
N
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3e
OH


4512
N
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3f
OH


4513
N
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4514
N
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4515
N
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4516
N
S
Q1c
a bond
Me
a bond
NH
O
NH
Q3d
OH


4517
N
S
Q1c
a bond
Me
a bond
NH
O
NH
Q3e
OH


4518
N
S
Q1c
a bond
Me
a bond
NH
O
NH
Q3f
OH


4519
N
S
Q1c
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4520
N
S
Q1c
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4521
N
S
Q1c
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4522
N
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3d
OH


4523
N
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3e
OH


4524
N
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3f
OH


4525
N
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4526
N
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4527
N
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4528
N
O
Q1a
a bond
Me
a bond
NH
O
NH
Q3d
OH


4529
N
O
Q1a
a bond
Me
a bond
NH
O
NH
Q3e
OH


4530
N
O
Q1a
a bond
Me
a bond
NH
O
NH
Q3f
OH


4531
N
O
Q1a
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4532
N
O
Q1a
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4533
N
O
Q1a
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4534
N
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3d
OH


4535
N
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3e
OH


4536
N
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3f
OH


4537
N
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4538
N
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4539
N
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4540
N
O
Q1b
a bond
Me
a bond
NH
O
NH
Q3d
OH


4541
N
O
Q1b
a bond
Me
a bond
NH
O
NH
Q3e
OH


4542
N
O
Q1b
a bond
Me
a bond
NH
O
NH
Q3f
OH


4543
N
O
Q1b
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4544
N
O
Q1b
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4545
N
O
Q1b
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4546
N
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3d
OH


4547
N
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3e
OH


4548
N
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3f
OH


4549
N
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4550
N
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4551
N
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4552
N
O
Q1c
a bond
Me
a bond
NH
O
NH
Q3d
OH


4553
N
O
Q1c
a bond
Me
a bond
NH
O
NH
Q3e
OH


4554
N
O
Q1c
a bond
Me
a bond
NH
O
NH
Q3f
OH


4555
N
O
Q1c
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4556
N
O
Q1c
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4557
N
O
Q1c
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4558
N
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3d
OH


4559
N
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3e
OH


4560
N
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3f
OH


4561
CH
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4562
CH
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4563
CH
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4564
CH
NMe
Q1a
a bond
Me
a bond
NH
O
NH
Q3d
OH


4565
CH
NMe
Q1a
a bond
Me
a bond
NH
O
NH
Q3e
OH


4566
CH
NMe
Q1a
a bond
Me
a bond
NH
O
NH
Q3f
OH


4567
CH
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4568
CH
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4569
CH
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4570
CH
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3d
OH


4571
CH
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3e
OH


4572
CH
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3f
OH


4573
CH
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4574
CH
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4575
CH
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4576
CH
NMe
Q1b
a bond
Me
a bond
NH
O
NH
Q3d
OH


4577
CH
NMe
Q1b
a bond
Me
a bond
NH
O
NH
Q3e
OH


4578
CH
NMe
Q1b
a bond
Me
a bond
NH
O
NH
Q3f
OH


4579
CH
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4580
CH
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4581
CH
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4582
CH
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3d
OH


4583
CH
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3e
OH


4584
CH
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3f
OH


4585
CH
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4586
CH
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4587
CH
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4588
CH
NMe
Q1c
a bond
Me
a bond
NH
O
NH
Q3d
OH


4589
CH
NMe
Q1c
a bond
Me
a bond
NH
O
NH
Q3e
OH


4590
CH
NMe
Q1c
a bond
Me
a bond
NH
O
NH
Q3f
OH


4591
CH
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4592
CH
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4593
CH
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4594
CH
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3d
OH


4595
CH
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3e
OH


4596
CH
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3f
OH


4597
CH
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4598
CH
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4599
CH
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4600
CH
NEt
Q1a
a bond
Me
a bond
NH
O
NH
Q3d
OH


4601
CH
NEt
Q1a
a bond
Me
a bond
NH
O
NH
Q3e
OH


4602
CH
NEt
Q1a
a bond
Me
a bond
NH
O
NH
Q3f
OH


4603
CH
NEt
Q1a
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4604
CH
NEt
Q1a
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4605
CH
NEt
Q1a
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4606
CH
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3d
OH


4607
CH
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3e
OH


4608
CH
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3f
OH


4609
CH
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4610
CH
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4611
CH
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4612
CH
NEt
Q1b
a bond
Me
a bond
NH
O
NH
Q3d
OH


4613
CH
NEt
Q1b
a bond
Me
a bond
NH
O
NH
Q3e
OH


4614
CH
NEt
Q1b
a bond
Me
a bond
NH
O
NH
Q3f
OH


4615
CH
NEt
Q1b
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4616
CH
NEt
Q1b
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4617
CH
NEt
Q1b
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4618
CH
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3d
OH


4619
CH
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3e
OH


4620
CH
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3f
OH


4621
CH
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4622
CH
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4623
CH
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4624
CH
NEt
Q1c
a bond
Me
a bond
NH
O
NH
Q3d
OH


4625
CH
NEt
Q1c
a bond
Me
a bond
NH
O
NH
Q3e
OH


4626
CH
NEt
Q1c
a bond
Me
a bond
NH
O
NH
Q3f
OH


4627
CH
NEt
Q1c
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4628
CH
NEt
Q1c
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4629
CH
NEt
Q1c
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4630
CH
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3d
OH


4631
CH
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3e
OH


4632
CH
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3f
OH


4633
CH
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4634
CH
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4635
CH
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4636
CH
S
Q1a
a bond
Me
a bond
NH
O
NH
Q3d
OH


4637
CH
S
Q1a
a bond
Me
a bond
NH
O
NH
Q3e
OH


4638
CH
S
Q1a
a bond
Me
a bond
NH
O
NH
Q3f
OH


4639
CH
S
Q1a
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4640
CH
S
Q1a
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4641
CH
S
Q1a
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4642
CH
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3d
OH


4643
CH
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3e
OH


4644
CH
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3f
OH


4645
CH
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4646
CH
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4647
CH
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4648
CH
S
Q1b
a bond
Me
a bond
NH
O
NH
Q3d
OH


4649
CH
S
Q1b
a bond
Me
a bond
NH
O
NH
Q3e
OH


4650
CH
S
Q1b
a bond
Me
a bond
NH
O
NH
Q3f
OH


4651
CH
S
Q1b
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4652
CH
S
Q1b
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4653
CH
S
Q1b
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4654
CH
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3d
OH


4655
CH
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3e
OH


4656
CH
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3f
OH


4657
CH
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4658
CH
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4659
CH
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4660
CH
S
Q1c
a bond
Me
a bond
NH
O
NH
Q3d
OH


4661
CH
S
Q1c
a bond
Me
a bond
NH
O
NH
Q3e
OH


4662
CH
S
Q1c
a bond
Me
a bond
NH
O
NH
Q3f
OH


4663
CH
S
Q1c
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4664
CH
S
Q1c
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4665
CH
S
Q1c
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4666
CH
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3d
OH


4667
CH
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3e
OH


4668
CH
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3f
OH


4669
CH
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4670
CH
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4671
CH
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4672
CH
O
Q1a
a bond
Me
a bond
NH
O
NH
Q3d
OH


4673
CH
O
Q1a
a bond
Me
a bond
NH
O
NH
Q3e
OH


4674
CH
O
Q1a
a bond
Me
a bond
NH
O
NH
Q3f
OH


4675
CH
O
Q1a
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4676
CH
O
Q1a
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4677
CH
O
Q1a
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4678
CH
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3d
OH


4679
CH
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3e
OH


4680
CH
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3f
OH


4681
CH
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4682
CH
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4683
CH
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4684
CH
O
Q1b
a bond
Me
a bond
NH
O
NH
Q3d
OH


4685
CH
O
Q1b
a bond
Me
a bond
NH
O
NH
Q3e
OH


4686
CH
O
Q1b
a bond
Me
a bond
NH
O
NH
Q3f
OH


4687
CH
O
Q1b
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4688
CH
O
Q1b
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4689
CH
O
Q1b
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4690
CH
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3d
OH


4691
CH
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3e
OH


4692
CH
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3f
OH


4693
CH
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4694
CH
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4695
CH
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4696
CH
O
Q1c
a bond
Me
a bond
NH
O
NH
Q3d
OH


4697
CH
O
Q1c
a bond
Me
a bond
NH
O
NH
Q3e
OH


4698
CH
O
Q1c
a bond
Me
a bond
NH
O
NH
Q3f
OH


4699
CH
O
Q1c
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4700
CH
O
Q1c
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4701
CH
O
Q1c
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4702
CH
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3d
OH


4703
CH
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3e
OH


4704
CH
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3f
OH


4705
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4706
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4707
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4708
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
NH
Q3d
OH


4709
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
NH
Q3e
OH


4710
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
NH
Q3f
OH


4711
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4712
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4713
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4714
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3d
OH


4715
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3e
OH


47l6
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3f
OH


4717
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4718
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4719
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4720
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
NH
Q3d
OH


4721
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
NH
Q3e
OH


4722
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
NH
Q3f
OH


4723
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4724
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4725
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4726
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3d
OH


4727
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3e
OH


4728
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3f
OH


4729
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4730
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4731
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4732
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
NH
Q3d
OH


4733
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
NH
Q3e
OH


4734
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
NH
Q3f
OH


4735
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4736
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4737
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4738
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3d
OH


4739
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3e
OH


4740
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3f
OH


4741
CMe
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4742
CMe
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4743
CMe
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4744
CMe
NEt
Q1a
a bond
Me
a bond
NH
O
NH
Q3d
OH


4745
CMe
NEt
Q1a
a bond
Me
a bond
NH
O
NH
Q3e
OH


4746
CMe
NEt
Q1a
a bond
Me
a bond
NH
O
NH
Q3f
OH


4747
CMe
NEt
Q1a
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4748
CMe
NEt
Q1a
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4749
CMe
NEt
Q1a
a bond
Me
a bond
NH
S
a bond
Q3f
OH


47S0
CMe
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3d
OH


4751
CMe
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3e
OH


4752
CMe
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3f
OH


4753
CMe
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4754
CMe
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4755
CMe
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3f
OH


47S6
CMe
NEt
Q1b
a bond
Me
a bond
NH
O
NH
Q3d
OH


47S7
CMe
NEt
Q1b
a bond
Me
a bond
NH
O
NH
Q3e
OH


4758
CMe
NEt
Q1b
a bond
Me
a bond
NH
O
NH
Q3f
OH


4759
CMe
NEt
Q1b
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4760
CMe
NEt
Q1b
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4761
CMe
NEt
Q1b
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4762
CMe
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3d
OH


4763
CMe
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3e
OH


4764
CMe
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3f
OH


4765
CMe
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4766
CMe
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4767
CMe
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4768
CMe
NEt
Q1c
a bond
Me
a bond
NH
O
NH
Q3d
OH


4769
CMe
NEt
Q1c
a bond
Me
a bond
NH
O
NH
Q3e
OH


4770
CMe
NEt
Q1c
a bond
Me
a bond
NH
O
NH
Q3f
OH


4771
CMe
NEt
Q1c
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4772
CMe
NEt
Q1c
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4773
CMe
NEt
Q1c
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4774
CMe
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3d
OH


4775
CMe
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3e
OH


4776
CMe
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3f
OH


4777
CMe
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4778
CMe
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4779
CMe
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4780
CMe
S
Q1a
a bond
Me
a bond
NH
O
NH
Q3d
OH


4781
CMe
S
Q1a
a bond
Me
a bond
NH
O
NH
Q3e
OH


4782
CMe
S
Q1a
a bond
Me
a bond
NH
O
NH
Q3f
OH


4783
CMe
S
Q1a
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4784
CMe
S
Q1a
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4785
CMe
S
Q1a
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4786
CMe
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3d
OH


4787
CMe
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3e
OH


4788
CMe
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3f
OH


4789
CMe
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4790
CMe
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4791
CMe
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4792
CMe
S
Q1b
a bond
Me
a bond
NH
O
NH
Q3d
OH


4793
CMe
S
Q1b
a bond
Me
a bond
NH
O
NH
Q3e
OH


4794
CMe
S
Q1b
a bond
Me
a bond
NH
O
NH
Q3f
OH


4795
CMe
S
Q1b
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4796
CMe
S
Q1b
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4797
CMe
S
Q1b
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4798
CMe
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3d
OH


4799
CMe
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3e
OH


4800
CMe
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3f
OH


4801
CMe
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4802
CMe
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4803
CMe
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4804
CMe
S
Q1c
a bond
Me
a bond
NH
O
NH
Q3d
OH


4805
CMe
S
Q1c
a bond
Me
a bond
NH
O
NH
Q3e
OH


4806
CMe
S
Q1c
a bond
Me
a bond
NH
O
NH
Q3f
OH


4807
CMe
S
Q1c
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4808
CMe
S
Q1c
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4809
CMe
S
Q1c
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4810
CMe
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3d
OH


4811
CMe
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3e
OH


4812
CMe
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3f
OH


4813
CMe
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4814
CMe
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4815
CMe
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4816
CMe
O
Q1a
a bond
Me
a bond
NH
O
NH
Q3d
OH


4817
CMe
O
Q1a
a bond
Me
a bond
NH
O
NH
Q3e
OH


4818
CMe
O
Q1a
a bond
Me
a bond
NH
O
NH
Q3f
OH


4819
CMe
O
Q1a
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4820
CMe
O
Q1a
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4821
CMe
O
Q1a
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4822
CMe
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3d
OH


4823
CMe
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3e
OH


4824
CMe
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3f
OH


4825
CMe
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4826
CMe
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4827
CMe
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4828
CMe
O
Q1b
a bond
Me
a bond
NH
O
NH
Q3d
OH


4829
CMe
O
Q1b
a bond
Me
a bond
NH
O
NH
Q3e
OH


4830
CMe
O
Q1b
a bond
Me
a bond
NH
O
NH
Q3f
OH


4831
CMe
O
Q1b
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4832
CMe
O
Q1b
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4833
CMe
O
Q1b
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4834
CMe
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3d
OH


4835
CMe
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3e
OH


4836
CMe
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3f
OH


4837
CMe
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3d
OH


4838
CMe
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4839
CMe
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3f
OH


4840
CMe
O
Q1c
a bond
Me
a bond
NH
O
NH
Q3d
OH


4841
CMe
O
Q1c
a bond
Me
a bond
NH
O
NH
Q3e
OH


4842
CMe
O
Q1c
a bond
Me
a bond
NH
O
NH
Q3f
OH


4843
CMe
O
Q1c
a bond
Me
a bond
NH
S
a bond
Q3d
OH


4844
CMe
O
Q1c
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4845
CMe
O
Q1c
a bond
Me
a bond
NH
S
a bond
Q3f
OH


4846
CMe
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3d
OH


4847
CMe
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3e
OH


4848
CMe
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3f
OH


4849
N
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3g
OH


4850
N
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3h
OH


4851
N
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3g
OH


4852
N
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3h
OH


4853
N
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3g
OH


4854
N
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3h
OH


4855
N
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3g
OH


4856
N
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3h
OH


4857
N
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3g
OH


4858
N
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3h
OH


4859
N
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3g
OH


4860
N
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3h
OH


4861
N
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3g
OH


4862
N
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3h
OH


4863
N
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3g
OH


4864
N
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3h
OH


4865
N
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3g
OH


4866
N
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3h
OH


4867
N
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3g
OH


4868
N
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3h
OH


4869
N
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3g
OH


4870
N
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3h
OH


4871
N
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3g
OH


4872
N
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3h
OH


4873
CH
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3g
OH


4874
CH
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3h
OH


4875
CH
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3g
OH


4876
CH
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3h
OH


4877
CH
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3g
OH


4878
CH
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3h
OH


4879
CH
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3g
OH


4880
CH
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3h
OH


4881
CH
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3g
OH


4882
CH
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3h
OH


4883
CH
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3g
OH


4884
CH
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3h
OH


4885
CH
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3g
OH


4886
CH
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3h
OH


4887
CH
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3g
OH


4888
CH
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3h
OH


4889
CH
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3g
OH


4890
CH
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3h
OH


4891
CH
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3g
OH


4892
CH
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3h
OH


4893
CH
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3g
OH


4894
CH
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3h
OH


4895
CH
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3g
OH


4896
CH
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3h
OH


4897
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3g
OH


4898
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3h
OH


4899
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3g
OH


4900
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3h
OH


4901
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3g
OH


4902
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3h
OH


4903
CMe
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3g
OH


4904
CMe
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3h
OH


4905
CMe
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3g
OH


4906
CMe
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3h
OH


4907
CMe
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3g
OH


4908
CMe
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3h
OH


4909
CMe
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3g
OH


4910
CMe
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3h
OH


4911
CMe
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3g
OH


4912
CMe
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3h
OH


4913
CMe
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3g
OH


4914
CMe
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3h
OH


4915
CMe
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3g
OH


4916
CMe
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3h
OH


4917
CMe
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3g
OH


4918
CMe
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3h
OH


4919
CMe
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3g
OH


4920
CMe
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3h
OH


4921
N
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4922
N
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4923
N
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4924
N
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4925
N
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4926
N
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4927
N
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4928
N
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4929
N
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4930
N
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4931
N
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4932
N
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4933
N
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4934
N
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4935
N
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4936
N
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4937
N
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4938
N
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4939
N
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4940
N
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4941
N
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4942
N
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4943
N
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4944
N
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4945
CH
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4946
CH
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4947
CH
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4948
CH
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4949
CH
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4950
CH
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4951
CH
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4952
CH
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4953
CH
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4954
CH
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4955
CH
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4956
CH
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4957
CH
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4958
CH
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4959
CH
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4960
CH
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4961
CH
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4962
CH
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4963
CH
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4964
CH
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4965
CH
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4966
CH
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4967
CH
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4968
CH
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4969
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4970
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4971
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4972
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4973
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4974
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4975
CMe
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4976
CMe
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4977
CMe
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4978
CMe
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4979
CMe
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4980
CMe
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4981
CMe
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4982
CMe
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4983
CMe
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4984
CMe
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4985
CMe
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4986
CMe
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4987
CMe
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4988
CMe
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4989
CMe
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4990
CMe
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4991
CMe
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3g
OH


4992
CMe
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4992
CMe
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3h
OH


4993
CH
NH
Q1a
a bond
Me
a bond
NH
S
NH
Q3a
OH


4994
CH
NH
Q1a
a bond
Me
a bond
NH
S
NH
Q3b
OH


4995
CH
NH
Q1a
a bond
Me
a bond
NH
S
NH
Q3c
OH


4996
CH
NH
Q1a
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4997
CH
NH
Q1a
a bond
Me
a bond
NH
S
a bond
Q3b
OH


4998
CH
NH
Q1a
a bond
Me
a bond
NH
S
a bond
Q3c
OH


4999
CH
NH
Q1a
a bond
Me
a bond
NH
O
NH
Q3a
OH


5000
CH
NH
Q1a
a bond
Me
a bond
NH
O
NH
Q3b
OH


5001
CH
NH
Q1a
a bond
Me
a bond
NH
O
NH
Q3c
OH


5002
CH
NH
Q1a
a bond
Me
a bond
NH
O
a bond
Q3a
OH


5003
CH
NH
Q1a
a bond
Me
a bond
NH
O
a bond
Q3b
OH


5004
CH
NH
Q1a
a bond
Me
a bond
NH
O
a bond
Q3c
OH


5005
CH
NH
Q1a
a bond
H
a bond
NH
S
NH
Q3a
OH


5006
CH
NH
Q1a
a bond
H
a bond
NH
S
NH
Q3b
OH


5007
CH
NH
Q1a
a bond
H
a bond
NH
S
NH
Q3c
OH


5008
CH
NH
Q1a
a bond
H
a bond
NH
S
a bond
Q3a
OH


5009
CH
NH
Q1a
a bond
H
a bond
NH
S
a bond
Q3b
OH


5010
CH
NH
Q1a
a bond
H
a bond
NH
S
a bond
Q3c
OH


5011
CH
NH
Q1a
a bond
H
a bond
NH
O
NH
Q3a
OH


5012
CH
NH
Q1a
a bond
H
a bond
NH
O
NH
Q3b
OH


5013
CH
NH
Q1a
a bond
H
a bond
NH
O
NH
Q3c
OH


5014
CH
NH
Q1a
a bond
H
a bond
NH
O
a bond
Q3a
OH


5015
CH
NH
Q1a
a bond
H
a bond
NH
O
a bond
Q3b
OH


5016
CH
NH
Q1a
a bond
H
a bond
NH
G
a bond
Q3c
OH


5017
CH
NH
Q1b
a bond
Me
a bond
NH
S
NH
Q3a
OH


5018
CH
NH
Q1b
a bond
Me
a bond
NH
S
NH
Q3b
OH


5019
CH
NH
Q1b
a bond
Me
a bond
NH
S
NH
Q3c
OH


5020
CH
NH
Q1b
a bond
Me
a bond
NH
S
a bond
Q3a
OH


5021
CH
NH
Q1b
a bond
Me
a bond
NH
S
a bond
Q3b
OH


5022
CH
NH
Q1b
a bond
Me
a bond
NH
S
a bond
Q3c
OH


5023
CH
NH
Q1b
a bond
Me
a bond
NH
O
NH
Q3a
OH


5024
CH
NH
Q1b
a bond
Me
a bond
NH
O
NH
Q3b
OH


5025
CH
NH
Q1b
a bond
Me
a bond
NH
O
NH
Q3c
OH


5026
CH
NH
Q1b
a bond
Me
a bond
NH
O
a bond
Q3a
OH


5027
CH
NH
Q1b
a bond
Me
a bond
NH
O
a bond
Q3b
OH


5028
CH
NH
Q1b
a bond
Me
a bond
NH
O
a bond
Q3c
OH


5029
CH
NH
Q1b
a bond
H
a bond
NH
S
NH
Q3a
OH


5030
CH
NH
Q1b
a bond
H
a bond
NH
S
NH
Q3b
OH


5031
CH
NH
Q1b
a bond
H
a bond
NH
S
NH
Q3c
OH


5032
CH
NH
Q1b
a bond
H
a bond
NH
S
a bond
Q3a
OH


5033
CH
NH
Q1b
a bond
H
a bond
NH
S
a bond
Q3b
OH


5034
CH
NH
Q1b
a bond
H
a bond
NH
S
a bond
Q3c
OH


5035
CH
NH
Q1b
a bond
H
a bond
NH
O
NH
Q3a
OH


5036
CH
NH
Q1b
a bond
H
a bond
NH
O
NH
Q3b
OH


5037
CH
NH
Q1b
a bond
H
a bond
NH
O
NH
Q3c
OH


5038
CH
NH
Q1b
a bond
H
a bond
NH
O
a bond
Q3a
OH


5039
CH
NH
Q1b
a bond
H
a bond
NH
O
a bond
Q3b
OH


5040
CH
NH
Q1b
a bond
H
a bond
NH
O
a bond
Q3c
OH


5041
CH
NH
Q1c
a bond
Me
a bond
NH
S
NH
Q3a
OH


5042
CH
NH
Q1c
a bond
Me
a bond
NH
S
NH
Q3b
OH


5043
CH
NH
Q1c
a bond
Me
a bond
NH
S
NH
Q3c
OH


5044
CH
NH
Q1c
a bond
Me
a bond
NH
S
a bond
Q3a
OH


5045
CH
NH
Q1c
a bond
Me
a bond
NH
S
a bond
Q3b
OH


5046
CH
NH
Q1c
a bond
Me
a bond
NH
S
a bond
Q3c
OH


5047
CH
NH
Q1c
a bond
Me
a bond
NH
O
NH
Q3a
OH


5048
CH
NH
Q1c
a bond
Me
a bond
NH
O
NH
Q3b
OH


5049
CH
NH
Q1c
a bond
Me
a bond
NH
O
NH
Q3c
OH


5050
CH
NH
Q1c
a bond
Me
a bond
NH
O
a bond
Q3a
OH


5051
CH
NH
Q1c
a bond
Me
a bond
NH
O
a bond
Q3b
OH


5052
CH
NH
Q1c
a bond
Me
a bond
NH
O
a bond
Q3c
OH


5053
CH
NH
Q1c
a bond
H
a bond
NH
S
NH
Q3a
OH


5054
CH
NH
Q1c
a bond
H
a bond
NH
S
NH
Q3b
OH


5055
CH
NH
Q1c
a bond
H
a bond
NH
S
NH
Q3c
OH


5056
CH
NH
Q1c
a bond
H
a bond
NH
S
a bond
Q3a
OH


5057
CH
NH
Q1c
a bond
H
a bond
NH
S
a bond
Q3b
OH


5058
CH
NH
Q1c
a bond
H
a bond
NH
S
a bond
Q3c
OH


5059
CH
NH
Q1c
a bond
H
a bond
NH
O
NH
Q3a
OH


5060
CH
NH
Q1c
a bond
H
a bond
NH
O
NH
Q3b
OH


5061
CH
NH
Q1c
a bond
H
a bond
NH
O
NH
Q3c
OH


5062
CH
NH
Q1c
a bond
H
a bond
NH
O
a bond
Q3a
OH


5063
CH
NH
Q1c
a bond
H
a bond
NH
O
a bond
Q3b
OH


5064
CH
NH
Q1c
a bond
H
a bond
NH
O
a bond
Q3c
OH


5065
CH
NH
Q1d
a bond
Me
a bond
NH
S
NH
Q3a
OH


5066
CH
NH
Q1d
a bond
Me
a bond
NH
S
NH
Q3b
OH


5067
CH
NH
Q1d
a bond
Me
a bond
NH
S
NH
Q3c
OH


5068
CH
NH
Q1d
a bond
Me
a bond
NH
S
a bond
Q3a
OH


5069
CH
NH
Q1d
a bond
Me
a bond
NH
S
a bond
Q3b
OH


5070
CH
NH
Q1d
a bond
Me
a bond
NH
S
a bond
Q3c
OH


5071
CH
NH
Q1d
a bond
Me
a bond
NH
O
NH
Q3a
OH


5072
CH
NH
Q1d
a bond
Me
a bond
NH
O
NH
Q3b
OH


5073
CH
NH
Q1d
a bond
Me
a bond
NH
O
NH
Q3c
OH


5074
CH
NH
Q1d
a bond
Me
a bond
NH
O
a bond
Q3a
OH


5075
CH
NH
Q1d
a bond
Me
a bond
NH
O
a bond
Q3b
OH


5076
CH
NH
Q1d
a bond
Me
a bond
NH
O
a bond
Q3c
OH


5077
CH
NH
Q1d
a bond
H
a bond
NH
S
NH
Q3a
OH


5078
CH
NH
Q1d
a bond
H
a bond
NH
S
NH
Q3b
OH


5079
CH
NH
Q1d
a bond
H
a bond
NH
S
NH
Q3c
OH


5080
CH
NH
Q1d
a bond
H
a bond
NH
S
a bond
Q3a
OH


5081
CH
NH
Q1d
a bond
H
a bond
NH
S
a bond
Q3b
OH


5082
CH
NH
Q1d
a bond
H
a bond
NH
S
a bond
Q3c
OH


5083
CH
NH
Q1d
a bond
H
a bond
NH
O
NH
Q3a
OH


5084
CH
NH
Q1d
a bond
H
a bond
NH
O
NH
Q3b
OH


5085
CH
NH
Q1d
a bond
H
a bond
NH
O
NH
Q3c
OH


5086
CH
NH
Q1d
a bond
H
a bond
NH
O
a bond
Q3a
OH


5087
CH
NH
Q1d
a bond
H
a bond
NH
O
a bond
Q3b
OH


5088
CH
NH
Q1d
a bond
H
a bond
NH
O
a bond
Q3c
OH


5089
CH
NH
Q1e
a bond
Me
a bond
NH
S
NH
Q3a
OH


5090
CH
NH
Q1e
a bond
Me
a bond
NH
S
NH
Q3b
OH


5091
CH
NH
Q1e
a bond
Me
a bond
NH
S
NH
Q3c
OH


5092
CH
NH
Q1e
a bond
Me
a bond
NH
S
a bond
Q3a
OH


5093
CH
NH
Q1e
a bond
Me
a bond
NH
S
a bond
Q3b
OH


5094
CH
NH
Q1e
a bond
Me
a bond
NH
S
a bond
Q3c
OH


5095
CH
NH
Q1e
a bond
Me
a bond
NH
O
NH
Q3a
OH


5096
CH
NH
Q1e
a bond
Me
a bond
NH
O
NH
Q3b
OH


5097
CH
NH
Q1e
a bond
Me
a bond
NH
O
NH
Q3c
OH


5098
CH
NH
Q1e
a bond
Me
a bond
NH
O
a bond
Q3a
OH


5099
CH
NH
Q1e
a bond
Me
a bond
NH
O
a bond
Q3b
OH


5100
CH
NH
Q1e
a bond
Me
a bond
NH
O
a bond
Q3c
OH


51O1
CH
NH
Q1e
a bond
H
a bond
NH
S
NH
Q3a
OH


5102
CH
NH
Q1e
a bond
H
a bond
NH
S
NH
Q3b
OH


5103
CH
NH
Q1e
a bond
H
a bond
NH
S
NH
Q3c
OH


5104
CH
NH
Q1e
a bond
H
a bond
NH
S
a bond
Q3a
OH


5105
CH
NH
Q1e
a bond
H
a bond
NH
S
a bond
Q3b
OH


5106
CH
NH
Q1e
a bond
H
a bond
NH
S
a bond
Q3c
OH


5107
CH
NH
Q1e
a bond
H
a bond
NH
O
NH
Q3a
OH


5108
CH
NH
Q1e
a bond
H
a bond
NH
O
NH
Q3b
OH


5109
CH
NH
Q1e
a bond
H
a bond
NH
O
NH
Q3c
OH


5110
CH
NH
Q1e
a bond
H
a bond
NH
O
a bond
Q3a
OH


5111
CH
NH
Q1e
a bond
H
a bond
NH
O
a bond
Q3b
OH


5112
CH
NH
Q1e
a bond
H
a bond
NH
O
a bond
Q3c
OH


5113
CH
NH
Q1f
a bond
Me
a bond
NH
S
NH
Q3a
OH


5114
CH
NH
Q1f
a bond
Me
a bond
NH
S
NH
Q3b
OH


5115
CH
NH
Q1f
a bond
Me
a bond
NH
S
NH
Q3c
OH


5116
CH
NH
Q1f
a bond
Me
a bond
NH
S
a bond
Q3a
OH


5117
CH
NH
Q1f
a bond
Me
a bond
NH
S
a bond
Q3b
OH


5118
CH
NH
Q1f
a bond
Me
a bond
NH
S
a bond
Q3c
OH


5119
CH
NH
Q1f
a bond
Me
a bond
NH
O
NH
Q3a
OH


5120
CH
NH
Q1f
a bond
Me
a bond
NH
O
NH
Q3b
OH


5121
CH
NH
Q1f
a bond
Me
a bond
NH
O
NH
Q3c
OH


5122
CH
NH
Q1f
a bond
Me
a bond
NH
O
a bond
Q3a
OH


5123
CH
NH
Q1f
a bond
Me
a bond
NH
O
a bond
Q3b
OH


5124
CH
NH
Q1f
a bond
Me
a bond
NH
O
a bond
Q3c
OH


5125
CH
NH
Q1f
a bond
H
a bond
NH
S
NH
Q3a
OH


5126
CH
NH
Q1f
a bond
H
a bond
NH
S
NH
Q3b
OH


5127
CH
NH
Q1f
a bond
H
a bond
NH
S
NH
Q3c
OH


5128
CH
NH
Q1f
a bond
H
a bond
NH
S
a bond
Q3a
OH


5129
CH
NH
Q1f
a bond
H
a bond
NH
S
a bond
Q3b
OH


5130
CH
NH
Q1f
a bond
H
a bond
NH
S
a bond
Q3c
OH


5131
CH
NH
Q1f
a bond
H
a bond
NH
O
NH
Q3a
OH


5132
CH
NH
Q1f
a bond
H
a bond
NH
O
NH
Q3b
OH


5133
CH
NH
Q1f
a bond
H
a bond
NH
O
NH
Q3c
OH


5134
CH
NH
Q1f
a bond
H
a bond
NH
O
a bond
Q3a
OH


5135
CH
NH
Q1f
a bond
H
a bond
NH
O
a bond
Q3b
OH


5136
CH
NH
Q1f
a bond
H
a bond
NH
O
a bond
Q3c
OH


5137
CH
NH
Q1g
a bond
Me
a bond
NH
S
NH
Q3a
OH


5138
CH
NH
Q1g
a bond
Me
a bond
NH
S
NH
Q3b
OH


5139
CH
NH
Q1g
a bond
Me
a bond
NH
S
NH
Q3c
OH


5140
CH
NH
Q1g
a bond
Me
a bond
NH
S
a bond
Q3a
OH


5141
CH
NH
Q1g
a bond
Me
a bond
NH
S
a bond
Q3b
OH


5142
CH
NH
Q1g
a bond
Me
a bond
NH
S
a bond
Q3c
OH


5143
CH
NH
Q1g
a bond
Me
a bond
NH
O
NH
Q3a
OH


5144
CH
NH
Q1g
a bond
Me
a bond
NH
O
NH
Q3b
OH


5145
CH
NH
Q1g
a bond
Me
a bond
NH
O
NH
Q3c
OH


5146
CH
NH
Q1g
a bond
Me
a bond
NH
O
a bond
Q3a
OH


5147
CH
NH
Q1g
a bond
Me
a bond
NH
O
a bond
Q3b
OH


5148
CH
NH
Q1g
a bond
Me
a bond
NH
O
a bond
Q3c
OH


5149
CH
NH
Q1g
a bond
H
a bond
NH
S
NH
Q3a
OH


5150
CH
NH
Q1g
a bond
H
a bond
NH
S
NH
Q3b
OH


5151
CH
NH
Q1g
a bond
H
a bond
NH
S
NH
Q3c
OH


5152
CH
NH
Q1g
a bond
H
a bond
NH
S
a bond
Q3a
OH


5153
CH
NH
Q1g
a bond
H
a bond
NH
S
a bond
Q3b
OH


5154
CH
NH
Q1g
a bond
H
a bond
NH
S
a bond
Q3c
OH


5155
CH
NH
Q1g
a bond
H
a bond
NH
O
NH
Q3a
OH


5156
CH
NH
Q1g
a bond
H
a bond
NH
O
NH
Q3b
OH


5157
CH
NH
Q1g
a bond
H
a bond
NH
O
NH
Q3c
OH


5158
CH
NH
Q1g
a bond
H
a bond
NH
O
a bond
Q3a
OH


5159
CH
NH
Q1g
a bond
H
a bond
NH
O
a bond
Q3b
OH


5160
CH
NH
Q1g
a bond
H
a bond
NH
O
a bond
Q3c
OH


5161
CH
NH
Q1h
a bond
Me
a bond
NH
S
NH
Q3a
OH


5162
CH
NH
Q1h
a bond
Me
a bond
NH
S
NH
Q3b
OH


5163
CH
NH
Q1h
a bond
Me
a bond
NH
S
NH
Q3c
OH


5164
CH
NH
Q1h
a bond
Me
a bond
NH
S
a bond
Q3a
OH


5165
CH
NH
Q1h
a bond
Me
a bond
NH
S
a bond
Q3b
OH


5166
CH
NH
Q1h
a bond
Me
a bond
NH
S
a bond
Q3c
OH


5167
CH
NH
Q1h
a bond
Me
a bond
NH
O
NH
Q3a
OH


5168
CH
NH
Q1h
a bond
Me
a bond
NH
O
NH
Q3b
OH


5169
CH
NH
Q1h
a bond
Me
a bond
NH
O
NH
Q3c
OH


5170
CH
NH
Q1h
a bond
Me
a bond
NH
O
a bond
Q3a
OH


5171
CH
NH
Q1h
a bond
Me
a bond
NH
O
a bond
Q3b
OH


5172
CH
NH
Q1h
a bond
Me
a bond
NH
O
a bond
Q3c
OH


5173
CH
NH
Q1h
a bond
H
a bond
NH
S
NH
Q3a
OH


5174
CH
NH
Q1h
a bond
H
a bond
NH
S
NH
Q3b
OH


5175
CH
NH
Q1h
a bond
H
a bond
NH
S
NH
Q3c
OH


5176
CH
NH
Q1h
a bond
H
a bond
NH
S
a bond
Q3a
OH


5177
CH
NH
Q1h
a bond
H
a bond
NH
S
a bond
Q3b
OH


5178
CH
NH
Q1h
a bond
H
a bond
NH
S
a bond
Q3c
OH


5179
CH
NH
Q1h
a bond
H
a bond
NH
O
NH
Q3a
OH


5180
CH
NH
Q1h
a bond
H
a bond
NH
O
NH
Q3b
OH


5181
CH
NH
Q1h
a bond
H
a bond
NH
O
NH
Q3c
OH


5182
CH
NH
Q1h
a bond
H
a bond
NH
O
a bond
Q3a
OH


5183
CH
NH
Q1h
a bond
H
a bond
NH
O
a bond
Q3b
OH


5184
CH
NH
Q1h
a bond
H
a bond
NH
O
a bond
Q3c
OH


5185
CH
NH
Q1i
a bond
Me
a bond
NH
S
NH
Q3a
OH


5186
CH
NH
Q1i
a bond
Me
a bond
NH
S
NH
Q3b
OH


5187
CH
NH
Q1i
a bond
Me
a bond
NH
S
NH
Q3c
OH


5188
CH
NH
Q1i
a bond
Me
a bond
NH
S
a bond
Q3a
OH


5189
CH
NH
Q1i
a bond
Me
a bond
NH
S
a bond
Q3b
OH


5190
CH
NH
Q1i
a bond
Me
a bond
NH
S
a bond
Q3c
OH


5191
CH
NH
Q1i
a bond
Me
a bond
NH
O
NH
Q3a
OH


5192
CH
NH
Q1i
a bond
Me
a bond
NH
O
NH
Q3b
OH


5193
CH
NH
Q1i
a bond
Me
a bond
NH
O
NH
Q3c
OH


5194
CH
NH
Q1i
a bond
Me
a bond
NH
O
a bond
Q3a
OH


5195
CH
NH
Q1i
a bond
Me
a bond
NH
O
a bond
Q3b
OH


5196
CH
NH
Q1i
a bond
Me
a bond
NH
O
a bond
Q3c
OH


5197
CH
NH
Q1i
a bond
H
a bond
NH
S
NH
Q3a
OH


5198
CH
NH
Q1i
a bond
H
a bond
NH
S
NH
Q3b
OH


5199
CH
NH
Q1i
a bond
H
a bond
NH
S
NH
Q3c
OH


5200
CH
NH
Q1i
a bond
H
a bond
NH
S
a bond
Q3a
OH


5201
CH
NH
Q1i
a bond
H
a bond
NH
S
a bond
Q3b
OH


5202
CH
NH
Q1i
a bond
H
a bond
NH
S
a bond
Q3c
OH


5203
CH
NH
Q1i
a bond
H
a bond
NH
O
NH
Q3a
OH


5204
CH
NH
Q1i
a bond
H
a bond
NH
O
NH
Q3b
OH


5205
CH
NH
Q1i
a bond
H
a bond
NH
O
NH
Q3c
OH


5206
CH
NH
Q1i
a bond
H
a bond
NH
O
a bond
Q3a
OH


5207
CH
NH
Q1i
a bond
H
a bond
NH
O
a bond
Q3b
OH


5208
CH
NH
Q1i
a bond
H
a bond
NH
O
a bond
Q3c
OH


5209
CH
NH
Q1j
a bond
Me
a bond
NH
S
NH
Q3a
OH


5210
CH
NH
Q1j
a bond
Me
a bond
NH
S
NH
Q3b
OH


5211
CH
NH
Q1j
a bond
Me
a bond
NH
S
NH
Q3c
OH


5212
CH
NH
Q1j
a bond
Me
a bond
NH
S
a bond
Q3a
OH


5213
CH
NH
Q1j
a bond
Me
a bond
NH
S
a bond
Q3b
OH


5214
CH
NH
Q1j
a bond
Me
a bond
NH
S
a bond
Q3c
OH


5215
CH
NH
Q1j
a bond
Me
a bond
NH
O
NH
Q3a
OH


5216
CH
NH
Q1j
a bond
Me
a bond
NH
O
NH
Q3b
OH


5217
CH
NH
Q1j
a bond
Me
a bond
NH
O
NH
Q3c
OH


5218
CH
NH
Q1j
a bond
Me
a bond
NH
O
a bond
Q3a
OH


5219
CH
NH
Q1j
a bond
Me
a bond
NH
O
a bond
Q3b
OH


5220
CH
NH
Q1j
a bond
Me
a bond
NH
O
a bond
Q3c
OH


5221
CH
NH
Q1j
a bond
H
a bond
NH
S
NH
Q3a
OH


5222
CH
NH
Q1j
a bond
H
a bond
NH
S
NH
Q3b
OH


5223
CH
NH
Q1j
a bond
H
a bond
NH
S
NH
Q3c
OH


5224
CH
NH
Q1j
a bond
H
a bond
NH
S
a bond
Q3a
OH


5225
CH
NH
Q1j
a bond
H
a bond
NH
S
a bond
Q3b
OH


5226
CH
NH
Q1j
a bond
H
a bond
NH
S
a bond
Q3c
OH


5227
CH
NH
Q1j
a bond
H
a bond
NH
O
NH
Q3a
OH


5228
CH
NH
Q1j
a bond
H
a bond
NH
O
NH
Q3b
OH


5229
CH
NH
Q1j
a bond
H
a bond
NH
O
NH
Q3c
OH


5230
CH
NH
Q1j
a bond
H
a bond
NH
O
a bond
Q3a
OH


5231
CH
NH
Q1j
a bond
H
a bond
NH
O
a bond
Q3b
OH


5232
CH
NH
Q1j
a bond
H
a bond
NH
O
a bond
Q3c
OH


5233
CMe
NH
Q1a
a bond
Me
a bond
NH
S
NH
Q3a
OH


5234
CMe
NH
Q1a
a bond
Me
a bond
NH
S
NH
Q3b
OH


5235
CMe
NH
Q1a
a bond
Me
a bond
NH
S
NH
Q3c
OH


5236
CMe
NH
Q1a
a bond
Me
a bond
NH
S
a bond
Q3a
OH


5237
CMe
NH
Q1a
a bond
Me
a bond
NH
S
a bond
Q3b
OH


5238
CMe
NH
Q1a
a bond
Me
a bond
NH
S
a bond
Q3c
OH


5239
CMe
NH
Q1a
a bond
Me
a bond
NH
O
NH
Q3a
OH


5240
CMe
NH
Q1a
a bond
Me
a bond
NH
O
NH
Q3b
OH


5241
CMe
NH
Q1a
a bond
Me
a bond
NH
O
NH
Q3c
OH


5242
CMe
NH
Q1a
a bond
Me
a bond
NH
O
a bond
Q3a
OH


5243
CMe
NH
Q1a
a bond
Me
a bond
NH
O
a bond
Q3b
OH


5244
CMe
NH
Q1a
a bond
Me
a bond
NH
O
a bond
Q3c
OH


5245
CMe
NH
Q1a
a bond
H
a bond
NH
S
NH
Q3a
OH


5246
CMe
NH
Q1a
a bond
H
a bond
NH
S
NH
Q3b
OH


5247
CMe
NH
Q1a
a bond
H
a bond
NH
S
NH
Q3c
OH


5248
CMe
NH
Q1a
a bond
H
a bond
NH
S
a bond
Q3a
OH


5249
CMe
NH
Q1a
a bond
H
a bond
NH
S
a bond
Q3b
OH


5250
CMe
NH
Q1a
a bond
H
a bond
NH
S
a bond
Q3c
OH


5251
CMe
NH
Q1a
a bond
H
a bond
NH
O
NH
Q3a
OH


5252
CMe
NH
Q1a
a bond
H
a bond
NH
O
NH
Q3b
OH


5253
CMe
NH
Q1a
a bond
H
a bond
NH
O
NH
Q3c
OH


5254
CMe
NH
Q1a
a bond
H
a bond
NH
O
a bond
Q3a
OH


5255
CMe
NH
Q1a
a bond
H
a bond
NH
O
a bond
Q3b
OH


5256
CMe
NH
Q1a
a bond
H
a bond
NH
O
a bond
Q3c
OH


5257
CMe
NH
Q1b
a bond
Me
a bond
NH
S
NH
Q3a
OH


5258
CMe
NH
Q1b
a bond
Me
a bond
NH
S
NH
Q3b
OH


5259
CMe
NH
Q1b
a bond
Me
a bond
NH
S
NH
Q3c
OH


5260
CMe
NH
Q1b
a bond
Me
a bond
NH
S
a bond
Q3a
OH


5261
CMe
NH
Q1b
a bond
Me
a bond
NH
S
a bond
Q3b
OH


5262
CMe
NH
Q1b
a bond
Me
a bond
NH
S
a bond
Q3c
OH


5263
CMe
NH
Q1b
a bond
Me
a bond
NH
O
NH
Q3a
OH


5264
CMe
NH
Q1b
a bond
Me
a bond
NH
O
NH
Q3b
OH


5265
CMe
NH
Q1b
a bond
Me
a bond
NH
O
NH
Q3c
OH


5266
CMe
NH
Q1b
a bond
Me
a bond
NH
O
a bond
Q3a
OH


5267
CMe
NH
Q1b
a bond
Me
a bond
NH
O
a bond
Q3b
OH


5268
CMe
NH
Q1b
a bond
Me
a bond
NH
O
a bond
Q3c
OH


5269
CMe
NH
Q1b
a bond
H
a bond
NH
S
NH
Q3a
OH


5270
CMe
NH
Q1b
a bond
H
a bond
NH
S
NH
Q3b
OH


5271
CMe
NH
Q1b
a bond
H
a bond
NH
S
NH
Q3c
OH


5272
CMe
NH
Q1b
a bond
H
a bond
NH
S
a bond
Q3a
OH


5273
CMe
NH
Q1b
a bond
H
a bond
NH
S
a bond
Q3b
OH


5274
CMe
NH
Q1b
a bond
H
a bond
NH
S
a bond
Q3c
OH


5275
CMe
NH
Q1b
a bond
H
a bond
NH
O
NH
Q3a
OH


5276
CMe
NH
Q1b
a bond
H
a bond
NH
O
NH
Q3b
OH


5277
CMe
NH
Q1b
a bond
H
a bond
NH
O
NH
Q3c
OH


5278
CMe
NH
Q1b
a bond
H
a bond
NH
O
a bond
Q3a
OH


5279
CMe
NH
Q1b
a bond
H
a bond
NH
O
a bond
Q3b
OH


5280
CMe
NH
Q1b
a bond
H
a bond
NH
O
a bond
Q3c
OH


5281
CMe
NH
Q1c
a bond
Me
a bond
NH
S
NH
Q3a
OH


5282
CMe
NH
Q1c
a bond
Me
a bond
NH
S
NH
Q3b
OH


5283
CMe
NH
Q1c
a bond
Me
a bond
NH
S
NH
Q3c
OH


5284
CMe
NH
Q1c
a bond
Me
a bond
NH
S
a bond
Q3a
OH


5285
CMe
NH
Q1c
a bond
Me
a bond
NH
S
a bond
Q3b
OH


5286
CMe
NH
Q1c
a bond
Me
a bond
NH
S
a bond
Q3c
OH


5287
CMe
NH
Q1c
a bond
Me
a bond
NH
O
NH
Q3a
OH


5288
CMe
NH
Q1c
a bond
Me
a bond
NH
O
NH
Q3b
OH


5289
CMe
NH
Q1c
a bond
Me
a bond
NH
O
NH
Q3c
OH


5290
CMe
NH
Q1c
a bond
Me
a bond
NH
O
a bond
Q3a
OH


5291
CMe
NH
Q1c
a bond
Me
a bond
NH
O
a bond
Q3b
OH


5292
CMe
NH
Q1c
a bond
Me
a bond
NH
O
a bond
Q3c
OH


5293
CMe
NH
Q1c
a bond
H
a bond
NH
S
NH
Q3a
OH


5294
CMe
NH
Q1c
a bond
H
a bond
NH
S
NH
Q3b
OH


5295
CMe
NH
Q1c
a bond
H
a bond
NH
S
NH
Q3c
OH


5296
CMe
NH
Q1c
a bond
H
a bond
NH
S
a bond
Q3a
OH


5297
CMe
NH
Q1c
a bond
H
a bond
NH
S
a bond
Q3b
OH


5298
CMe
NH
Q1c
a bond
H
a bond
NH
S
a bond
Q3c
OH


5299
CMe
NH
Q1c
a bond
H
a bond
NH
O
NH
Q3a
OH


5300
CMe
NH
Q1c
a bond
H
a bond
NH
O
NH
Q3b
OH


5301
CMe
NH
Q1c
a bond
H
a bond
NH
O
NH
Q3c
OH


5302
CMe
NH
Q1c
a bond
H
a bond
NH
O
a bond
Q3a
OH


5303
CMe
NH
Q1c
a bond
H
a bond
NH
O
a bond
Q3b
OH


5304
CMe
NH
Q1c
a bond
H
a bond
NH
O
a bond
Q3c
OH


5305
CMe
NH
Q1d
a bond
Me
a bond
NH
S
NH
Q3a
OH


5306
CMe
NH
Q1d
a bond
Me
a bond
NH
S
NH
Q3b
OH


5307
CMe
NH
Q1d
a bond
Me
a bond
NH
S
NH
Q3c
OH


5308
CMe
NH
Q1d
a bond
Me
a bond
NH
S
a bond
Q3a
OH


5309
CMe
NH
Q1d
a bond
Me
a bond
NH
S
a bond
Q3b
OH


5310
CMe
NH
Q1d
a bond
Me
a bond
NH
S
a bond
Q3c
OH


5311
CMe
NH
Q1d
a bond
Me
a bond
NH
O
NH
Q3a
OH


5312
CMe
NH
Q1d
a bond
Me
a bond
NH
O
NH
Q3b
OH


5313
CMe
NH
Q1d
a bond
Me
a bond
NH
O
NH
Q3c
OH


5314
CMe
NH
Q1d
a bond
Me
a bond
NH
O
a bond
Q3a
OH


5315
CMe
NH
Q1d
a bond
Me
a bond
NH
O
a bond
Q3b
OH


5316
CMe
NH
Q1d
a bond
Me
a bond
NH
O
a bond
Q3c
OH


5317
CMe
NH
Q1d
a bond
H
a bond
NH
S
NH
Q3a
OH


5318
CMe
NH
Q1d
a bond
H
a bond
NH
S
NH
Q3b
OH


5319
CMe
NH
Q1d
a bond
H
a bond
NH
S
NH
Q3c
OH


5320
CMe
NH
Q1d
a bond
H
a bond
NH
S
a bond
Q3a
OH


5321
CMe
NH
Q1d
a bond
H
a bond
NH
S
a bond
Q3b
OH


5322
CMe
NH
Q1d
a bond
H
a bond
NH
S
a bond
Q3c
OH


5323
CMe
NH
Q1d
a bond
H
a bond
NH
O
NH
Q3a
OH


5324
CMe
NH
Q1d
a bond
H
a bond
NH
O
NH
Q3b
OH


5325
CMe
NH
Q1d
a bond
H
a bond
NH
O
NH
Q3c
OH


5326
CMe
NH
Q1d
a bond
H
a bond
NH
O
a bond
Q3a
OH


5327
CMe
NH
Q1d
a bond
H
a bond
NH
O
a bond
Q3b
OH


5328
CMe
NH
Q1d
a bond
H
a bond
NH
O
a bond
Q3c
OH


5329
CMe
NH
Q1e
a bond
Me
a bond
NH
S
NH
Q3a
OH


5330
CMe
NH
Q1e
a bond
Me
a bond
NH
S
NH
Q3b
OH


5331
CMe
NH
Q1e
a bond
Me
a bond
NH
S
NH
Q3c
OH


5332
CMe
NH
Q1e
a bond
Me
a bond
NH
S
a bond
Q3a
OH


5333
CMe
NH
Q1e
a bond
Me
a bond
NH
S
a bond
Q3b
OH


5334
CMe
NH
Q1e
a bond
Me
a bond
NH
S
a bond
Q3c
OH


5335
CMe
NH
Q1e
a bond
Me
a bond
NH
O
NH
Q3a
OH


5336
CMe
NH
Q1e
a bond
Me
a bond
NH
O
NH
Q3b
OH


5337
CMe
NH
Q1e
a bond
Me
a bond
NH
O
NH
Q3c
OH


5338
CMe
NH
Q1e
a bond
Me
a bond
NH
O
a bond
Q3a
OH


5339
CMe
NH
Q1e
a bond
Me
a bond
NH
O
a bond
Q3b
OH


5340
CMe
NH
Q1e
a bond
Me
a bond
NH
O
a bond
Q3c
OH


5341
CMe
NH
Q1e
a bond
H
a bond
NH
S
NH
Q3a
OH


5342
CMe
NH
Q1e
a bond
H
a bond
NH
S
NH
Q3b
OH


5343
CMe
NH
Q1e
a bond
H
a bond
NH
S
NH
Q3c
OH


5344
CMe
NH
Q1e
a bond
H
a bond
NH
S
a bond
Q3a
OH


5345
CMe
NH
Q1e
a bond
H
a bond
NH
S
a bond
Q3b
OH


5346
CMe
NH
Q1e
a bond
H
a bond
NH
S
a bond
Q3c
OH


5347
CMe
NH
Q1e
a bond
H
a bond
NH
O
NH
Q3a
OH


5348
CMe
NH
Q1e
a bond
H
a bond
NH
O
NH
Q3b
OH


5349
CMe
NH
Q1e
a bond
H
a bond
NH
O
NH
Q3c
OH


5350
CMe
NH
Q1e
a bond
H
a bond
NH
O
a bond
Q3a
OH


5351
CMe
NH
Q1e
a bond
H
a bond
NH
O
a bond
Q3b
OH


5352
CMe
NH
Q1e
a bond
H
a bond
NH
O
a bond
Q3c
OH


5353
CMe
NH
Q1f
a bond
Me
a bond
NH
S
NH
Q3a
OH


5354
CMe
NH
Q1f
a bond
Me
a bond
NH
S
NH
Q3b
OH


5355
CMe
NH
Q1f
a bond
Me
a bond
NH
S
NH
Q3c
OH


5356
CMe
NH
Q1f
a bond
Me
a bond
NH
S
a bond
Q3a
OH


5357
CMe
NH
Q1f
a bond
Me
a bond
NH
S
a bond
Q3b
OH


5358
CMe
NH
Q1f
a bond
Me
a bond
NH
S
a bond
Q3c
OH


5359
CMe
NH
Q1f
a bond
Me
a bond
NH
O
NH
Q3a
OH


5360
CMe
NH
Q1f
a bond
Me
a bond
NH
O
NH
Q3b
OH


5361
CMe
NH
Q1f
a bond
Me
a bond
NH
O
NH
Q3c
OH


5362
CMe
NH
Q1f
a bond
Me
a bond
NH
O
a bond
Q3a
OH


5363
CMe
NH
Q1f
a bond
Me
a bond
NH
O
a bond
Q3b
OH


5364
CMe
NH
Q1f
a bond
Me
a bond
NH
O
a bond
Q3c
OH


5365
CMe
NH
Q1f
a bond
H
a bond
NH
S
NH
Q3a
OH


5366
CMe
NH
Q1f
a bond
H
a bond
NH
S
NH
Q3b
OH


5367
CMe
NH
Q1f
a bond
H
a bond
NH
S
NH
Q3c
OH


5368
CMe
NH
Q1f
a bond
H
a bond
NH
S
a bond
Q3a
OH


5369
CMe
NH
Q1f
a bond
H
a bond
NH
S
a bond
Q3b
OH


5370
CMe
NH
Q1f
a bond
H
a bond
NH
S
a bond
Q3c
OH


5371
CMe
NH
Q1f
a bond
H
a bond
NH
O
NH
Q3a
OH


5372
CMe
NH
Q1f
a bond
H
a bond
NH
O
NH
Q3b
OH


5373
CMe
NH
Q1f
a bond
H
a bond
NH
O
NH
Q3c
OH


5374
CMe
NH
Q1f
a bond
H
a bond
NH
O
a bond
Q3a
OH


5375
CMe
NH
Q1f
a bond
H
a bond
NH
O
a bond
Q3b
OH


5376
CMe
NH
Q1f
a bond
H
a bond
NH
O
a bond
Q3c
OH


5377
CMe
NH
Q1g
a bond
Me
a bond
NH
S
NH
Q3a
OH


5378
CMe
NH
Q1g
a bond
Me
a bond
NH
S
NH
Q3b
OH


5379
CMe
NH
Q1g
a bond
Me
a bond
NH
S
NH
Q3c
OH


5380
CMe
NH
Q1g
a bond
Me
a bond
NH
S
a bond
Q3a
OH


5381
CMe
NH
Q1g
a bond
Me
a bond
NH
S
a bond
Q3b
OH


5382
CMe
NH
Q1g
a bond
Me
a bond
NH
S
a bond
Q3c
OH


5383
CMe
NH
Q1g
a bond
Me
a bond
NH
O
NH
Q3a
OH


5384
CMe
NH
Q1g
a bond
Me
a bond
NH
O
NH
Q3b
OH


5385
CMe
NH
Q1g
a bond
Me
a bond
NH
O
NH
Q3c
OH


5386
CMe
NH
Q1g
a bond
Me
a bond
NH
O
a bond
Q3a
OH


5387
CMe
NH
Q1g
a bond
Me
a bond
NH
O
a bond
Q3b
OH


5388
CMe
NH
Q1g
a bond
Me
a bond
NH
O
a bond
Q3c
OH


5389
CMe
NH
Q1g
a bond
H
a bond
NH
S
NH
Q3a
OH


5390
CMe
NH
Q1g
a bond
H
a bond
NH
S
NH
Q3b
OH


5391
CMe
NH
Q1g
a bond
H
a bond
NH
S
NH
Q3c
OH


5392
CMe
NH
Q1g
a bond
H
a bond
NH
S
a bond
Q3a
OH


5393
CMe
NH
Q1g
a bond
H
a bond
NH
S
a bond
Q3b
OH


5394
CMe
NH
Q1g
a bond
H
a bond
NH
S
a bond
Q3c
OH


5395
CMe
NH
Q1g
a bond
H
a bond
NH
O
NH
Q3a
OH


5396
CMe
NH
Q1g
a bond
H
a bond
NH
O
NH
Q3b
OH


5397
CMe
NH
Q1g
a bond
H
a bond
NH
O
NH
Q3c
OH


5398
CMe
NH
Q1g
a bond
H
a bond
NH
O
a bond
Q3a
OH


5399
CMe
NH
Q1g
a bond
H
a bond
NH
O
a bond
Q3b
OH


5400
CMe
NH
Q1g
a bond
H
a bond
NH
O
a bond
Q3c
OH


5401
CMe
NH
Q1h
a bond
Me
a bond
NH
S
NH
Q3a
OH


5402
CMe
NH
Q1h
a bond
Me
a bond
NH
S
NH
Q3b
OH


5403
CMe
NH
Q1h
a bond
Me
a bond
NH
S
NH
Q3c
OH


5404
CMe
NH
Q1h
a bond
Me
a bond
NH
S
a bond
Q3a
OH


5405
CMe
NH
Q1h
a bond
Me
a bond
NH
S
a bond
Q3b
OH


5406
CMe
NH
Q1h
a bond
Me
a bond
NH
S
a bond
Q3c
OH


5407
CMe
NH
Q1h
a bond
Me
a bond
NH
O
NH
Q3a
OH


5408
CMe
NH
Q1h
a bond
Me
a bond
NH
O
NH
Q3b
OH


5409
CMe
NH
Q1h
a bond
Me
a bond
NH
O
NH
Q3c
OH


5410
CMe
NH
Q1h
a bond
Me
a bond
NH
O
a bond
Q3a
OH


5411
CMe
NH
Q1h
a bond
Me
a bond
NH
O
a bond
Q3b
OH


5412
CMe
NH
Q1h
a bond
Me
a bond
NH
O
a bond
Q3c
OH


5413
CMe
NH
Q1h
a bond
H
a bond
NH
S
NH
Q3a
OH


5414
CMe
NH
Q1h
a bond
H
a bond
NH
S
NH
Q3b
OH


5415
CMe
NH
Q1h
a bond
H
a bond
NH
S
NH
Q3c
OH


5416
CMe
NH
Q1h
a bond
H
a bond
NH
S
a bond
Q3a
OH


5417
CMe
NH
Q1h
a bond
H
a bond
NH
S
a bond
Q3b
OH


5418
CMe
NH
Q1h
a bond
H
a bond
NH
S
a bond
Q3c
OH


5419
CMe
NH
Q1h
a bond
H
a bond
NH
O
NH
Q3a
OH


5420
CMe
NH
Q1h
a bond
H
a bond
NH
O
NH
Q3b
OH


5421
CMe
NH
Q1h
a bond
H
a bond
NH
O
NH
Q3c
OH


5422
CMe
NH
Q1h
a bond
H
a bond
NH
O
a bond
Q3a
OH


5423
CMe
NH
Q1h
a bond
H
a bond
NH
O
a bond
Q3b
OH


5424
CMe
NH
Q1h
a bond
H
a bond
NH
O
a bond
Q3c
OH


5425
CMe
NH
Q1i
a bond
Me
a bond
NH
S
NH
Q3a
OH


5426
CMe
NH
Q1i
a bond
Me
a bond
NH
S
NH
Q3b
OH


5427
CMe
NH
Q1i
a bond
Me
a bond
NH
S
NH
Q3c
OH


5428
CMe
NH
Q1i
a bond
Me
a bond
NH
S
a bond
Q3a
OH


5429
CMe
NH
Q1i
a bond
Me
a bond
NH
S
a bond
Q3b
OH


5430
CMe
NH
Q1i
a bond
Me
a bond
NH
S
a bond
Q3c
OH


5431
CMe
NH
Q1i
a bond
Me
a bond
NH
O
NH
Q3a
OH


5432
CMe
NH
Q1i
a bond
Me
a bond
NH
O
NH
Q3b
OH


5433
CMe
NH
Q1i
a bond
Me
a bond
NH
O
NH
Q3c
OH


5434
CMe
NH
Q1i
a bond
Me
a bond
NH
O
a bond
Q3a
OH


5435
CMe
NH
Q1i
a bond
Me
a bond
NH
O
a bond
Q3b
OH


5436
CMe
NH
Q1i
a bond
Me
a bond
NH
O
a bond
Q3c
OH


5437
CMe
NH
Q1i
a bond
H
a bond
NH
S
NH
Q3a
OH


5438
CMe
NH
Q1i
a bond
H
a bond
NH
S
NH
Q3b
OH


5439
CMe
NH
Q1i
a bond
H
a bond
NH
S
NH
Q3c
OH


5440
CMe
NH
Q1i
a bond
H
a bond
NH
S
a bond
Q3a
OH


5441
CMe
NH
Q1i
a bond
H
a bond
NH
S
a bond
Q3b
OH


5442
CMe
NH
Q1i
a bond
H
a bond
NH
S
a bond
Q3c
OH


5443
CMe
NH
Q1i
a bond
H
a bond
NH
O
NH
Q3a
OH


5444
CMe
NH
Q1i
a bond
H
a bond
NH
O
NH
Q3b
OH


5445
CMe
NH
Q1i
a bond
H
a bond
NH
O
NH
Q3c
OH


5446
CMe
NH
Q1i
a bond
H
a bond
NH
O
a bond
Q3a
OH


5447
CMe
NH
Q1i
a bond
H
a bond
NH
O
a bond
Q3b
OH


5448
CMe
NH
Q1i
a bond
H
a bond
NH
O
a bond
Q3c
OH


5449
CMe
NH
Q1j
a bond
Me
a bond
NH
S
NH
Q3a
OH


5450
CMe
NH
Q1j
a bond
Me
a bond
NH
S
NH
Q3b
OH


5451
CMe
NH
Q1j
a bond
Me
a bond
NH
S
NH
Q3c
OH


5452
CMe
NH
Q1j
a bond
Me
a bond
NH
S
a bond
Q3a
OH


5453
CMe
NH
Q1j
a bond
Me
a bond
NH
S
a bond
Q3b
OH


5454
CMe
NH
Q1j
a bond
Me
a bond
NH
S
a bond
Q3c
OH


5455
CMe
NH
Q1j
a bond
Me
a bond
NH
O
NH
Q3a
OH


5456
CMe
NH
Q1j
a bond
Me
a bond
NH
O
NH
Q3b
OH


5457
CMe
NH
Q1j
a bond
Me
a bond
NH
O
NH
Q3c
OH


5458
CMe
NH
Q1j
a bond
Me
a bond
NH
O
a bond
Q3a
OH


5459
CMe
NH
Q1j
a bond
Me
a bond
NH
O
a bond
Q3b
OH


5460
CMe
NH
Q1j
a bond
Me
a bond
NH
O
a bond
Q3c
OH


5461
CMe
NH
Q1j
a bond
H
a bond
NH
S
NH
Q3a
OH


5462
CMe
NH
Q1j
a bond
H
a bond
NH
S
NH
Q3b
OH


5463
CMe
NH
Q1j
a bond
H
a bond
NH
S
NH
Q3c
OH


5464
CMe
NH
Q1j
a bond
H
a bond
NH
S
a bond
Q3a
OH


5465
CMe
NH
Q1j
a bond
H
a bond
NH
S
a bond
Q3b
OH


5466
CMe
NH
Q1j
a bond
H
a bond
NH
S
a bond
Q3c
OH


5467
CMe
NH
Q1j
a bond
H
a bond
NH
O
NH
Q3a
OH


5468
CMe
NH
Q1j
a bond
H
a bond
NH
O
NH
Q3b
OH


5469
CMe
NH
Q1j
a bond
H
a bond
NH
O
NH
Q3c
OH


5470
CMe
NH
Q1j
a bond
H
a bond
NH
O
a bond
Q3a
OH


5471
CMe
NH
Q1j
a bond
H
a bond
NH
O
a bond
Q3b
OH


5472
CMe
NH
Q1j
a bond
H
a bond
NH
O
a bond
Q3c
OH










The symbols in Table 1 denote the flowing substituents.


Q1a = 





Q1b = 





Q1c = 





Q1d = 





Q1e = 





Q1f = 





Q1g = 





Q1h = 





Q1i = 





Q1j = 





Q1k = 





Q1l = 





Q1m = 





Q1n = 





Q1k′ = 





Q1l′ = 





Q1m′ = 





Q1n′ = 





Q3a = 





Q3b = 





Q3c = 





Q3d = 





Q3e = 





Q3f = 





Q3g = 





Q3h = 









69) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 2, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. The symbols in Table 2 denote the flowing substituents.


















TABLE 2





No.
A
B
R1
L1
R2
L2
L3
Y
L4
R3
X


























1
N
NMe
Q1o
a bond
Me
a bond
NH
S
NH
Q3a
OH


2
N
NMe
Q1o
a bond
Me
a bond
NH
S
NH
Q3b
OH


3
N
NMe
Q1o
a bond
Me
a bond
NH
S
NH
Q3c
OH


4
N
NMe
Q1o
a bond
Me
a bond
NH
S
a bond
Q3a
OH


5
N
NMe
Q1o
a bond
Me
a bond
NH
S
a bond
Q3b
OH


6
N
NMe
Q1o
a bond
Me
a bond
NH
S
a bond
Q3c
OH


7
N
NMe
Q1o
a bond
Me
a bond
NH
O
NH
Q3a
OH


8
N
NMe
Q1o
a bond
Me
a bond
NH
O
NH
Q3b
OH


9
N
NMe
Q1o
a bond
Me
a bond
NH
O
NH
Q3c
OH


10
N
NMe
Q1o
a bond
Me
a bond
NH
O
abond
Q3a
OH


11
N
NMe
Q1o
a bond
Me
a bond
NH
O
abond
Q3b
OH


12
N
NMe
Q1o
a bond
Me
a bond
NH
O
a bond
Q3c
OH


13
N
NMe
Q1o
a bond
H
a bond
NH
S
NH
Q3a
OH


14
N
NMe
Q1o
a bond
H
a bond
NH
S
NH
Q3b
OH


15
N
NMe
Q1o
a bond
H
a bond
NH
S
NH
Q3c
OH


16
N
NMe
Q1o
a bond
H
a bond
NH
S
abond
Q3a
OH


17
N
NMe
Q1o
a bond
H
a bond
NH
S
abond
Q3b
OH


18
N
NMe
Q1o
a bond
H
a bond
NH
S
a bond
Q3c
OH


19
N
NMe
Q1o
a bond
H
a bond
NH
O
NH
Q3a
OH


20
N
NMe
Q1o
a bond
H
a bond
NH
O
NH
Q3b
OH


21
N
NMe
Q1o
a bond
H
a bond
NH
O
NH
Q3c
OH


22
N
NMe
Q1o
a bond
H
a bond
NH
O
a bond
Q3a
OH


23
N
NMe
Q1o
a bond
H
a bond
NH
O
a bond
Q3b
OH


24
N
NMe
Q1o
a bond
H
a bond
NH
O
a bond
Q3c
OH


25
N
NMe
Q1p
a bond
Me
a bond
NH
S
NH
Q3a
OH


26
N
NMe
Q1p
a bond
Me
a bond
NH
S
NH
Q3b
OH


27
N
NMe
Q1p
a bond
Me
a bond
NH
S
NH
Q3c
OH


28
N
NMe
Q1p
a bond
Me
a bond
NH
S
a bond
Q3a
OH


29
N
NMe
Q1p
a bond
Me
a bond
NH
S
a bond
Q3b
OH


30
N
NMe
Q1p
a bond
Me
a bond
NH
S
a bond
Q3c
OH


31
N
NMe
Q1p
a bond
Me
a bond
NH
O
NH
Q3a
OH


32
N
NMe
Q1p
a bond
Me
a bond
NH
O
NH
Q3b
OH


33
N
NMe
Q1p
a bond
Me
a bond
NH
O
NH
Q3c
OH


34
N
NMe
Q1p
a bond
Me
a bond
NH
O
a bond
Q3a
OH


35
N
NMe
Q1p
a bond
Me
a bond
NH
O
a bond
Q3b
OH


36
N
NMe
Q1p
a bond
Me
a bond
NH
O
a bond
Q3c
OH


37
N
NMe
Q1p
a bond
H
a bond
NH
S
NH
Q3a
OH


38
N
NMe
Q1p
a bond
H
a bond
NH
S
NH
Q3b
OH


39
N
NMe
Q1p
a bond
H
a bond
NH
S
NH
Q3c
OH


40
N
NMe
Q1p
a bond
H
a bond
NH
S
a bond
Q3a
OH


41
N
NMe
Q1p
a bond
H
a bond
NH
S
a bond
Q3b
OH


42
N
NMe
Q1p
a bond
H
a bond
NH
S
a bond
Q3c
OH


43
N
NMe
Q1p
a bond
H
a bond
NH
O
NH
Q3a
OH


44
N
NMe
Q1p
a bond
H
a bond
NH
O
NH
Q3b
OH


45
N
NMe
Q1p
a bond
H
a bond
NH
O
NH
Q3c
OH


46
N
NMe
Q1p
a bond
H
a bond
NH
O
a bond
Q3a
OH


47
N
NMe
Q1p
a bond
H
a bond
NH
O
a bond
Q3b
OH


48
N
NMe
Q1p
a bond
H
a bond
NH
O
a bond
Q3c
OH


49
N
NMe
Q1q
a bond
Me
a bond
NH
S
NH
Q3a
OH


50
N
NMe
Q1q
a bond
Me
a bond
NH
S
NH
Q3b
OH


51
N
NMe
Q1q
a bond
Me
a bond
NH
S
NH
Q3c
OH


52
N
NMe
Q1q
a bond
Me
a bond
NH
S
a bond
Q3a
OH


53
N
NMe
Q1q
a bond
Me
a bond
NH
S
a bond
Q3b
OH


54
N
NMe
Q1q
a bond
Me
a bond
NH
S
a bond
Q3c
OH


55
N
NMe
Q1q
a bond
Me
a bond
NH
O
NH
Q3a
OH


56
N
NMe
Q1q
a bond
Me
a bond
NH
O
NH
Q3b
OH


57
N
NMe
Q1q
a bond
Me
a bond
NH
O
NH
Q3c
OH


58
N
NMe
Q1q
a bond
Me
a bond
NH
O
a bond
Q3a
OH


59
N
NMe
Q1q
a bond
Me
a bond
NH
O
a bond
Q3b
OH


60
N
NMe
Q1q
a bond
Me
a bond
NH
O
a bond
Q3c
OH


61
N
NMe
Q1q
a bond
H
a bond
NH
S
NH
Q3a
OH


62
N
NMe
Q1q
a bond
H
a bond
NH
S
NH
Q3b
OH


63
N
NMe
Q1q
a bond
H
a bond
NH
S
NH
Q3c
OH


64
N
NMe
Q1q
a bond
H
a bond
NH
S
a bond
Q3a
OH


65
N
NMe
Q1q
a bond
H
a bond
NH
S
a bond
Q3b
OH


66
N
NMe
Q1q
a bond
H
a bond
NH
S
a bond
Q3c
OH


67
N
NMe
Q1q
a bond
H
a bond
NH
O
NH
Q3a
OH


68
N
NMe
Q1q
a bond
H
a bond
NH
O
NH
Q3b
OH


69
N
NMe
Q1q
a bond
H
a bond
NH
O
NH
Q3c
OH


70
N
NMe
Q1q
a bond
H
a bond
NH
O
a bond
Q3a
OH


71
N
NMe
Q1q
a bond
H
a bond
NH
O
a bond
Q3b
OH


72
N
NMe
Q1q
a bond
H
a bond
NH
O
a bond
Q3c
OH


73
N
NMe
Q1r
a bond
Me
a bond
NH
S
NH
Q3a
OH


74
N
NMe
Q1r
a bond
Me
a bond
NH
S
NH
Q3b
OH


75
N
NMe
Q1r
a bond
Me
a bond
NH
S
NH
Q3c
OH


76
N
NMe
Q1r
a bond
Me
a bond
NH
S
a bond
Q3a
OH


77
N
NMe
Q1r
a bond
Me
a bond
NH
S
a bond
Q3b
OH


78
N
NMe
Q1r
a bond
Me
a bond
NH
S
a bond
Q3c
OH


79
N
NMe
Q1r
a bond
Me
a bond
NH
O
NH
Q3a
OH


80
N
NMe
Q1r
a bond
Me
a bond
NH
O
NH
Q3b
OH


81
N
NMe
Q1r
a bond
Me
a bond
NH
O
NH
Q3c
OH


82
N
NMe
Q1r
a bond
Me
a bond
NH
O
a bond
Q3a
OH


83
N
NMe
Q1r
a bond
Me
a bond
NH
O
a bond
Q3b
OH


84
N
NMe
Q1r
a bond
Me
a bond
NH
O
a bond
Q3c
OH


85
N
NMe
Q1r
a bond
H
a bond
NH
S
NH
Q3a
OH


86
N
NMe
Q1r
a bond
H
a bond
NH
S
NH
Q3b
OH


87
N
NMe
Q1r
a bond
H
a bond
NH
S
NH
Q3c
OH


88
N
NMe
Q1r
a bond
H
a bond
NH
S
a bond
Q3a
OH


89
N
NMe
Q1r
a bond
H
a bond
NH
S
a bond
Q3b
OH


90
N
NMe
Q1r
a bond
H
a bond
NH
S
a bond
Q3c
OH


91
N
NMe
Q1r
a bond
H
a bond
NH
O
NH
Q3a
OH


92
N
NMe
Q1r
a bond
H
a bond
NH
O
NH
Q3b
OH


93
N
NMe
Q1r
a bond
H
a bond
NH
O
NH
Q3c
OH


94
N
NMe
Q1r
a bond
H
a bond
NH
O
a bond
Q3a
OH


95
N
NMe
Q1r
a bond
H
a bond
NH
O
a bond
Q3b
OH


96
N
NMe
Q1r
a bond
H
a bond
NH
O
a bond
Q3c
OH


97
N
NMe
Q1s
a bond
Me
a bond
NH
S
NH
Q3a
OH


98
N
NMe
Q1s
a bond
Me
a bond
NH
S
NH
Q3b
OH


99
N
NMe
Q1s
a bond
Me
a bond
NH
S
NH
Q3c
OH


100
N
NMe
Q1s
a bond
Me
a bond
NH
S
a bond
Q3a
OH


101
N
NMe
Q1s
a bond
Me
a bond
NH
S
a bond
Q3b
OH


102
N
NMe
Q1s
a bond
Me
a bond
NH
S
a bond
Q3c
OH


103
N
NMe
Q1s
a bond
Me
a bond
NH
O
NH
Q3a
OH


104
N
NMe
Q1s
a bond
Me
a bond
NH
O
NH
Q3b
OH


105
N
NMe
Q1s
a bond
Me
a bond
NH
O
NH
Q3c
OH


106
N
NMe
Q1s
a bond
Me
a bond
NH
O
a bond
Q3a
OH


107
N
NMe
Q1s
a bond
Me
a bond
NH
O
a bond
Q3b
OH


108
N
NMe
Q1s
a bond
Me
a bond
NH
O
a bond
Q3c
OH


109
N
NMe
Q1s
a bond
H
a bond
NH
S
NH
Q3a
OH


110
N
NMe
Q1s
a bond
H
a bond
NH
S
NH
Q3b
OH


111
N
NMe
Q1s
a bond
H
a bond
NH
S
NH
Q3c
OH


112
N
NMe
Q1s
a bond
H
a bond
NH
S
a bond
Q3a
OH


113
N
NMe
Q1s
a bond
H
a bond
NH
S
a bond
Q3b
OH


114
N
NMe
Q1s
a bond
H
a bond
NH
S
a bond
Q3c
OH


115
N
NMe
Q1s
a bond
H
a bond
NH
O
NH
Q3a
OH


116
N
NMe
Q1s
a bond
H
a bond
NH
O
NH
Q3b
OH


117
N
NMe
Q1s
a bond
H
a bond
NH
O
NH
Q3c
OH


118
N
NMe
Q1s
a bond
H
a bond
NH
O
a bond
Q3a
OH


119
N
NMe
Q1s
a bond
H
a bond
NH
O
a bond
Q3b
OH


120
N
NMe
Q1s
a bond
H
a bond
NH
O
a bond
Q3c
OH


121
N
NMe
Q1t
a bond
Me
a bond
NH
S
NH
Q3a
OH


122
N
NMe
Q1t
a bond
Me
a bond
NH
S
NH
Q3b
OH


123
N
NMe
Q1t
a bond
Me
a bond
NH
S
NH
Q3c
OH


124
N
NMe
Q1t
a bond
Me
a bond
NH
S
a bond
Q3a
OH


125
N
NMe
Q1t
a bond
Me
a bond
NH
S
a bond
Q3b
OH


126
N
NMe
Q1t
a bond
Me
a bond
NH
S
a bond
Q3c
OH


127
N
NMe
Q1t
a bond
Me
a bond
NH
O
NH
Q3a
OH


128
N
NMe
Q1t
a bond
Me
a bond
NH
O
NH
Q3b
OH


129
N
NMe
Q1t
a bond
Me
a bond
NH
O
NH
Q3c
OH


130
N
NMe
Q1t
a bond
Me
a bond
NH
O
a bond
Q3a
OH


131
N
NMe
Q1t
a bond
Me
a bond
NH
O
a bond
Q3b
OH


132
N
NMe
Q1t
a bond
Me
a bond
NH
O
a bond
Q3c
OH


133
N
NMe
Q1t
a bond
H
a bond
NH
S
NH
Q3a
OH


134
N
NMe
Q1t
a bond
H
a bond
NH
S
NH
Q3b
OH


135
N
NMe
Q1t
a bond
H
a bond
NH
S
NH
Q3c
OH


136
N
NMe
Q1t
a bond
H
a bond
NH
S
a bond
Q3a
OH


137
N
NMe
Q1t
a bond
H
a bond
NH
S
a bond
Q3b
OH


138
N
NMe
Q1t
a bond
H
a bond
NH
S
a bond
Q3c
OH


139
N
NMe
Q1t
a bond
H
a bond
NH
O
NH
Q3a
OH


140
N
NMe
Q1t
a bond
H
a bond
NH
O
NH
Q3b
OH


141
N
NMe
Q1t
a bond
H
a bond
NH
O
NH
Q3c
OH


142
N
NMe
Q1t
a bond
H
a bond
NH
O
a bond
Q3a
OH


143
N
NMe
Q1t
a bond
H
a bond
NH
O
a bond
Q3b
OH


144
N
NMe
Q1t
a bond
H
a bond
NH
O
a bond
Q3c
OH


145
N
NMe
Q1u
a bond
Me
a bond
NH
S
NH
Q3a
OH


146
N
NMe
Q1u
a bond
Me
a bond
NH
S
NH
Q3b
OH


147
N
NMe
Q1u
a bond
Me
a bond
NH
S
NH
Q3c
OH


148
N
NMe
Q1u
a bond
Me
a bond
NH
S
a bond
Q3a
OH


149
N
NMe
Q1u
a bond
Me
a bond
NH
S
a bond
Q3b
OH


150
N
NMe
Q1u
a bond
Me
a bond
NH
S
a bond
Q3c
OH


151
N
NMe
Q1u
a bond
Me
a bond
NH
O
NH
Q3a
OH


152
N
NMe
Q1u
a bond
Me
a bond
NH
O
NH
Q3b
OH


153
N
NMe
Q1u
a bond
Me
a bond
NH
O
NH
Q3c
OH


154
N
NMe
Q1u
a bond
Me
a bond
NH
O
a bond
Q3a
OH


155
N
NMe
Q1u
a bond
Me
a bond
NH
O
a bond
Q3b
OH


156
N
NMe
Q1u
a bond
Me
a bond
NH
O
a bond
Q3c
OH


157
N
NMe
Q1u
a bond
H
a bond
NH
S
NH
Q3a
OH


158
N
NMe
Q1u
a bond
H
a bond
NH
S
NH
Q3b
OH


159
N
NMe
Q1u
a bond
H
a bond
NH
S
NH
Q3c
OH


160
N
NMe
Q1u
a bond
H
a bond
NH
S
a bond
Q3a
OH


161
N
NMe
Q1u
a bond
H
a bond
NH
S
a bond
Q3b
OH


162
N
NMe
Q1u
a bond
H
a bond
NH
S
a bond
Q3c
OH


163
N
NMe
Q1u
a bond
H
a bond
NH
O
NH
Q3a
OH


164
N
NMe
Q1u
a bond
H
a bond
NH
O
NH
Q3b
OH


165
N
NMe
Q1u
a bond
H
a bond
NH
O
NH
Q3c
OH


166
N
NMe
Q1u
a bond
H
a bond
NH
O
a bond
Q3a
OH


167
N
NMe
Q1u
a bond
H
a bond
NH
O
a bond
Q3b
OH


168
N
NMe
Q1u
a bond
H
a bond
NH
O
a bond
Q3c
OH


169
N
NMe
Q1v
a bond
Me
a bond
NH
S
NH
Q3a
OH


170
N
NMe
Q1v
a bond
Me
a bond
NH
S
NH
Q3b
OH


171
N
NMe
Q1v
a bond
Me
a bond
NH
S
NH
Q3c
OH


172
N
NMe
Q1v
a bond
Me
a bond
NH
S
a bond
Q3a
OH


173
N
NMe
Q1v
a bond
Me
a bond
NH
S
a bond
Q3b
OH


174
N
NMe
Q1v
a bond
Me
a bond
NH
S
a bond
Q3c
OH


175
N
NMe
Q1v
a bond
Me
a bond
NH
O
NH
Q3a
OH


176
N
NMe
Q1v
a bond
Me
a bond
NH
O
NH
Q3b
OH


177
N
NMe
Q1v
a bond
Me
a bond
NH
O
NH
Q3c
OH


178
N
NMe
Q1v
a bond
Me
a bond
NH
O
a bond
Q3a
OH


179
N
NMe
Q1v
a bond
Me
a bond
NH
O
a bond
Q3b
OH


180
N
NMe
Q1v
a bond
Me
a bond
NH
O
a bond
Q3c
OH


181
N
NMe
Q1v
a bond
H
a bond
NH
S
NH
Q3a
OH


182
N
NMe
Q1v
a bond
H
a bond
NH
S
NH
Q3b
OH


183
N
NMe
Q1v
a bond
H
a bond
NH
S
NH
Q3c
OH


184
N
NMe
Q1v
a bond
H
a bond
NH
S
a bond
Q3a
OH


185
N
NMe
Q1v
a bond
H
a bond
NH
S
a bond
Q3b
OH


186
N
NMe
Q1v
a bond
H
a bond
NH
S
a bond
Q3c
OH


187
N
NMe
Q1v
a bond
H
a bond
NH
O
NH
Q3a
OH


188
N
NMe
Q1v
a bond
H
a bond
NH
O
NH
Q3b
OH


189
N
NMe
Q1v
a bond
H
a bond
NH
O
NH
Q3c
OH


190
N
NMe
Q1v
a bond
H
a bond
NH
O
a bond
Q3a
OH


191
N
NMe
Q1v
a bond
H
a bond
NH
O
a bond
Q3b
OH


192
N
NMe
Q1v
a bond
H
a bond
NH
O
a bond
Q3c
OH


193
N
NMe
Q1w
a bond
Me
a bond
NH
S
NH
Q3a
OH


194
N
NMe
Q1w
a bond
Me
a bond
NH
S
NH
Q3b
OH


195
N
NMe
Q1w
a bond
Me
a bond
NH
S
NH
Q3c
OH


196
N
NMe
Q1w
a bond
Me
a bond
NH
S
a bond
Q3a
OH


197
N
NMe
Q1w
a bond
Me
a bond
NH
S
a bond
Q3b
OH


198
N
NMe
Q1w
a bond
Me
a bond
NH
S
a bond
Q3c
OH


199
N
NMe
Q1w
a bond
Me
a bond
NH
O
NH
Q3a
OH


200
N
NMe
Q1w
a bond
Me
a bond
NH
O
NH
Q3b
OH


201
N
NMe
Q1w
a bond
Me
a bond
NH
O
NH
Q3c
OH


202
N
NMe
Q1w
a bond
Me
a bond
NH
O
a bond
Q3a
OH


203
N
NMe
Q1w
a bond
Me
a bond
NH
O
a bond
Q3b
OH


204
N
NMe
Q1w
a bond
Me
a bond
NH
O
a bond
Q3c
OH


205
N
NMe
Q1w
a bond
H
a bond
NH
S
NH
Q3a
OH


206
N
NMe
Q1w
a bond
H
a bond
NH
S
NH
Q3b
OH


207
N
NMe
Q1w
a bond
H
a bond
NH
S
NH
Q3c
OH


208
N
NMe
Q1w
a bond
H
a bond
NH
S
a bond
Q3a
OH


209
N
NMe
Q1w
a bond
H
a bond
NH
S
a bond
Q3b
OH


210
N
NMe
Q1w
a bond
H
a bond
NH
S
a bond
Q3c
OH


211
N
NMe
Q1w
a bond
H
a bond
NH
O
NH
Q3a
OH


212
N
NMe
Q1w
a bond
H
a bond
NH
O
NH
Q3b
OH


213
N
NMe
Q1w
a bond
H
a bond
NH
O
NH
Q3c
OH


214
N
NMe
Q1w
a bond
H
a bond
NH
O
a bond
Q3a
OH


215
N
NMe
Q1w
a bond
H
a bond
NH
O
a bond
Q3b
OH


216
N
NMe
Q1w
a bond
H
a bond
NH
O
a bond
Q3c
OH


217
N
NMe
Q1x
a bond
Me
a bond
NH
S
NH
Q3a
OH


218
N
NMe
Q1x
a bond
Me
a bond
NH
S
NH
Q3b
OH


219
N
NMe
Q1x
a bond
Me
a bond
NH
S
NH
Q3c
OH


220
N
NMe
Q1x
a bond
Me
a bond
NH
S
a bond
Q3a
OH


221
N
NMe
Q1x
a bond
Me
a bond
NH
S
a bond
Q3b
OH


222
N
NMe
Q1x
a bond
Me
a bond
NH
S
a bond
Q3c
OH


223
N
NMe
Q1x
a bond
Me
a bond
NH
O
NH
Q3a
OH


224
N
NMe
Q1x
a bond
Me
a bond
NH
O
NH
Q3b
OH


225
N
NMe
Q1x
a bond
Me
a bond
NH
O
NH
Q3c
OH


226
N
NMe
Q1x
a bond
Me
a bond
NH
O
a bond
Q3a
OH


227
N
NMe
Q1x
a bond
Me
a bond
NH
O
a bond
Q3b
OH


228
N
NMe
Q1x
a bond
Me
a bond
NH
O
a bond
Q3c
OH


229
N
NMe
Q1x
a bond
H
a bond
NH
S
NH
Q3a
OH


230
N
NMe
Q1x
a bond
H
a bond
NH
S
NH
Q3b
OH


231
N
NMe
Q1x
a bond
H
a bond
NH
S
NH
Q3c
OH


232
N
NMe
Q1x
a bond
H
a bond
NH
S
a bond
Q3a
OH


233
N
NMe
Q1x
a bond
H
a bond
NH
S
a bond
Q3b
OH


234
N
NMe
Q1x
a bond
H
a bond
NH
S
a bond
Q3c
OH


235
N
NMe
Q1x
a bond
H
a bond
NH
O
NH
Q3a
OH


236
N
NMe
Q1x
a bond
H
a bond
NH
O
NH
Q3b
OH


237
N
NMe
Q1x
a bond
H
a bond
NH
O
NH
Q3c
OH


238
N
NMe
Q1x
a bond
H
a bond
NH
O
a bond
Q3a
OH


239
N
NMe
Q1x
a bond
H
a bond
NH
O
a bond
Q3b
OH


240
N
NMe
Q1x
a bond
H
a bond
NH
O
a bond
Q3c
OH


241
N
NEt
Q1o
a bond
Me
a bond
NH
S
NH
Q3a
OH


242
N
NEt
Q1o
a bond
Me
a bond
NH
S
NH
Q3b
OH


243
N
NEt
Q1o
a bond
Me
a bond
NH
S
NH
Q3c
OH


244
N
NEt
Q1o
a bond
Me
a bond
NH
S
a bond
Q3a
OH


245
N
NEt
Q1o
a bond
Me
a bond
NH
S
a bond
Q3b
OH


246
N
NEt
Q1o
a bond
Me
a bond
NH
S
a bond
Q3c
OH


247
N
NEt
Q1o
a bond
Me
a bond
NH
O
NH
Q3a
OH


248
N
NEt
Q1o
a bond
Me
a bond
NH
O
NH
Q3b
OH


249
N
NEt
Q1o
a bond
Me
a bond
NH
O
NH
Q3c
OH


250
N
NEt
Q1o
a bond
Me
a bond
NH
O
a bond
Q3a
OH


251
N
NEt
Q1o
a bond
Me
a bond
NH
O
a bond
Q3b
OH


252
N
NEt
Q1o
a bond
Me
a bond
NH
O
a bond
Q3c
OH


253
N
NEt
Q1o
a bond
H
a bond
NH
S
NH
Q3a
OH


254
N
NEt
Q1o
a bond
H
a bond
NH
S
NH
Q3b
OH


255
N
NEt
Q1o
a bond
H
a bond
NH
S
NH
Q3c
OH


256
N
NEt
Q1o
a bond
H
a bond
NH
S
a bond
Q3a
OH


257
N
NEt
Q1o
a bond
H
a bond
NH
S
a bond
Q3b
OH


258
N
NEt
Q1o
a bond
H
a bond
NH
S
a bond
Q3c
OH


259
N
NEt
Q1o
a bond
H
a bond
NH
O
NH
Q3a
OH


260
N
NEt
Q1o
a bond
H
a bond
NH
O
NH
Q3b
OH


261
N
NEt
Q1o
a bond
H
a bond
NH
O
NH
Q3c
OH


262
N
NEt
Q1o
a bond
H
a bond
NH
O
a bond
Q3a
OH


263
N
NEt
Q1o
a bond
H
a bond
NH
O
a bond
Q3b
OH


264
N
NEt
Q1o
a bond
H
a bond
NH
O
a bond
Q3c
OH


265
N
NEt
Q1p
a bond
Me
a bond
NH
S
NH
Q3a
OH


266
N
NEt
Q1p
a bond
Me
a bond
NH
S
NH
Q3b
OH


267
N
NEt
Q1p
a bond
Me
a bond
NH
S
NH
Q3c
OH


268
N
NEt
Q1p
a bond
Me
a bond
NH
S
a bond
Q3a
OH


269
N
NEt
Q1p
a bond
Me
a bond
NH
S
a bond
Q3b
OH


270
N
NEt
Q1p
a bond
Me
a bond
NH
S
a bond
Q3c
OH


271
N
NEt
Q1p
a bond
Me
a bond
NH
O
NH
Q3a
OH


272
N
NEt
Q1p
a bond
Me
a bond
NH
O
NH
Q3b
OH


273
N
NEt
Q1p
a bond
Me
a bond
NH
O
NH
Q3c
OH


274
N
NEt
Q1p
a bond
Me
a bond
NH
O
a bond
Q3a
OH


275
N
NEt
Q1p
a bond
Me
a bond
NH
O
a bond
Q3b
OH


276
N
NEt
Q1p
a bond
Me
a bond
NH
O
a bond
Q3c
OH


277
N
NEt
Q1p
a bond
H
a bond
NH
S
NH
Q3a
OH


278
N
NEt
Q1p
a bond
H
a bond
NH
S
NH
Q3b
OH


279
N
NEt
Q1p
a bond
H
a bond
NH
S
NH
Q3c
OH


280
N
NEt
Q1p
a bond
H
a bond
NH
S
a bond
Q3a
OH


281
N
NEt
Q1p
a bond
H
a bond
NH
S
a bond
Q3b
OH


282
N
NEt
Q1p
a bond
H
a bond
NH
S
a bond
Q3c
OH


283
N
NEt
Q1p
a bond
H
a bond
NH
O
NH
Q3a
OH


284
N
NEt
Q1p
a bond
H
a bond
NH
O
NH
Q3b
OH


285
N
NEt
Q1p
a bond
H
a bond
NH
O
NH
Q3c
OH


286
N
NEt
Q1p
a bond
H
a bond
NH
O
a bond
Q3a
OH


287
N
NEt
Q1p
a bond
H
a bond
NH
O
a bond
Q3b
OH


288
N
NEt
Q1p
a bond
H
a bond
NH
O
a bond
Q3c
OH


289
N
NEt
Q1q
a bond
Me
a bond
NH
S
NH
Q3a
OH


290
N
NEt
Q1q
a bond
Me
a bond
NH
S
NH
Q3b
OH


291
N
NEt
Q1q
a bond
Me
a bond
NH
S
NH
Q3c
OH


292
N
NEt
Q1q
a bond
Me
a bond
NH
S
a bond
Q3a
OH


293
N
NEt
Q1q
a bond
Me
a bond
NH
S
a bond
Q3b
OH


294
N
NEt
Q1q
a bond
Me
a bond
NH
S
a bond
Q3c
OH


295
N
NEt
Q1q
a bond
Me
a bond
NH
O
NH
Q3a
OH


296
N
NEt
Q1q
a bond
Me
a bond
NH
O
NH
Q3b
OH


297
N
NEt
Q1q
a bond
Me
a bond
NH
O
NH
Q3c
OH


298
N
NEt
Q1q
a bond
Me
a bond
NH
O
a bond
Q3a
OH


299
N
NEt
Q1q
a bond
Me
a bond
NH
O
a bond
Q3b
OH


300
N
NEt
Q1q
a bond
Me
a bond
NH
O
a bond
Q3c
OH


301
N
NEt
Q1p
a bond
H
a bond
NH
S
NH
Q3a
OH


302
N
NEt
Q1q
a bond
H
a bond
NH
S
NH
Q3b
OH


303
N
NEt
Q1q
a bond
H
a bond
NH
S
NH
Q3c
OH


304
N
NEt
Q1q
a bond
H
a bond
NH
S
a bond
Q3a
OH


305
N
NEt
Q1q
a bond
H
a bond
NH
S
a bond
Q3b
OH


306
N
NEt
Q1q
a bond
H
a bond
NH
S
a bond
Q3c
OH


307
N
NEt
Q1q
a bond
H
a bond
NH
O
NH
Q3a
OH


308
N
NEt
Q1q
a bond
H
a bond
NH
O
NH
Q3b
OH


309
N
NEt
Q1q
a bond
H
a bond
NH
O
NH
Q3c
OH


310
N
NEt
Q1q
a bond
H
a bond
NH
O
a bond
Q3a
OH


311
N
NEt
Q1q
a bond
H
a bond
NH
O
a bond
Q3b
OH


312
N
NEt
Q1q
a bond
H
a bond
NH
O
a bond
Q3c
OH


313
N
NEt
Q1r
a bond
Me
a bond
NH
S
NH
Q3a
OH


314
N
NEt
Q1r
a bond
Me
a bond
NH
S
NH
Q3b
OH


315
N
NEt
Q1r
a bond
Me
a bond
NH
S
NH
Q3c
OH


316
N
NEt
Q1r
a bond
Me
a bond
NH
S
a bond
Q3a
OH


317
N
NEt
Q1r
a bond
Me
a bond
NH
S
a bond
Q3b
OH


318
N
NEt
Q1r
a bond
Me
a bond
NH
S
a bond
Q3c
OH


319
N
NEt
Q1r
a bond
Me
a bond
NH
O
NH
Q3a
OH


320
N
NEt
Q1r
a bond
Me
a bond
NH
O
NH
Q3b
OH


321
N
NEt
Q1r
a bond
Me
a bond
NH
O
NH
Q3c
OH


322
N
NEt
Q1r
a bond
Me
a bond
NH
O
a bond
Q3a
OH


323
N
NEt
Q1r
a bond
Me
a bond
NH
O
a bond
Q3b
OH


324
N
NEt
Q1r
a bond
Me
a bond
NH
O
a bond
Q3c
OH


325
N
NEt
Q1r
a bond
H
a bond
NH
S
NH
Q3a
OH


326
N
NEt
Q1r
a bond
H
a bond
NH
S
NH
Q3b
OH


327
N
NEt
Q1r
a bond
H
a bond
NH
S
NH
Q3c
OH


328
N
NEt
Q1r
a bond
H
a bond
NH
S
a bond
Q3a
OH


329
N
NEt
Q1r
a bond
H
a bond
NH
S
a bond
Q3b
OH


330
N
NEt
Q1r
a bond
H
a bond
NH
S
a bond
Q3c
OH


331
N
NEt
Q1r
a bond
H
a bond
NH
O
NH
Q3a
OH


332
N
NEt
Q1r
a bond
H
a bond
NH
O
NH
Q3b
OH


333
N
NEt
Q1r
a bond
H
a bond
NH
O
NH
Q3c
OH


334
N
NEt
Q1r
a bond
H
a bond
NH
O
a bond
Q3a
OH


335
N
NEt
Q1r
a bond
H
a bond
NH
O
a bond
Q3b
OH


336
N
NEt
Q1r
a bond
H
a bond
NH
O
a bond
Q3c
OH


337
N
NEt
Q1s
a bond
Me
a bond
NH
S
NH
Q3a
OH


338
N
NEt
Q1s
a bond
Me
a bond
NH
S
NH
Q3b
OH


339
N
NEt
Q1s
a bond
Me
a bond
NH
S
NH
Q3c
OH


340
N
NEt
Q1s
a bond
Me
a bond
NH
S
a bond
Q3a
OH


341
N
NEt
Q1s
a bond
Me
a bond
NH
S
a bond
Q3b
OH


342
N
NEt
Q1s
a bond
Me
a bond
NH
S
a bond
Q3c
OH


343
N
NEt
Q1s
a bond
Me
a bond
NH
O
NH
Q3a
OH


344
N
NEt
Q1s
a bond
Me
a bond
NH
O
NH
Q3b
OH


345
N
NEt
Q1s
a bond
Me
a bond
NH
O
NH
Q3c
OH


346
N
NEt
Q1s
a bond
Me
a bond
NH
O
a bond
Q3a
OH


347
N
NEt
Q1s
a bond
Me
a bond
NH
O
a bond
Q3b
OH


348
N
NEt
Q1s
a bond
Me
a bond
NH
O
a bond
Q3c
OH


349
N
NEt
Q1s
a bond
H
a bond
NH
S
NH
Q3a
OH


350
N
NEt
Q1s
a bond
H
a bond
NH
S
NH
Q3b
OH


351
N
NEt
Q1s
a bond
H
a bond
NH
S
NH
Q3c
OH


352
N
NEt
Q1s
a bond
H
a bond
NH
S
a bond
Q3a
OH


353
N
NEt
Q1s
a bond
H
a bond
NH
S
a bond
Q3b
OH


354
N
NEt
Q1s
a bond
H
a bond
NH
S
a bond
Q3c
OH


355
N
NEt
Q1s
a bond
H
a bond
NH
O
NH
Q3a
OH


356
N
NEt
Q1s
a bond
H
a bond
NH
O
NH
Q3b
OH


357
N
NEt
Q1s
a bond
H
a bond
NH
O
NH
Q3c
OH


358
N
NEt
Q1s
a bond
H
a bond
NH
O
a bond
Q3a
OH


359
N
NEt
Q1s
a bond
H
a bond
NH
O
a bond
Q3b
OH


360
N
NEt
Q1s
a bond
H
a bond
NH
O
a bond
Q3c
OH


361
N
NEt
Q1t
a bond
Me
a bond
NH
S
NH
Q3a
OH


362
N
NEt
Q1t
a bond
Me
a bond
NH
S
NH
Q3b
OH


363
N
NEt
Q1t
a bond
Me
a bond
NH
S
NH
Q3c
OH


364
N
NEt
Q1t
a bond
Me
a bond
NH
S
a bond
Q3a
OH


365
N
NEt
Q1t
a bond
Me
a bond
NH
S
a bond
Q3b
OH


366
N
NEt
Q1t
a bond
Me
a bond
NH
S
a bond
Q3c
OH


367
N
NEt
Q1t
a bond
Me
a bond
NH
O
NH
Q3a
OH


368
N
NEt
Q1t
a bond
Me
a bond
NH
O
NH
Q3b
OH


369
N
NEt
Q1t
a bond
Me
a bond
NH
O
NH
Q3c
OH


370
N
NEt
Q1t
a bond
Me
a bond
NH
O
a bond
Q3a
OH


371
N
NEt
Q1t
a bond
Me
a bond
NH
O
a bond
Q3b
OH


372
N
NEt
Q1t
a bond
Me
a bond
NH
O
a bond
Q3c
OH


373
N
NEt
Q1t
a bond
H
a bond
NH
S
NH
Q3a
OH


374
N
NEt
Q1t
a bond
H
a bond
NH
S
NH
Q3b
OH


375
N
NEt
Q1t
a bond
H
a bond
NH
S
NH
Q3c
OH


376
N
NEt
Q1t
a bond
H
a bond
NH
S
a bond
Q3a
OH


377
N
NEt
Q1t
a bond
H
a bond
NH
S
a bond
Q3b
OH


378
N
NEt
Q1t
a bond
H
a bond
NH
S
a bond
Q3c
OH


379
N
NEt
Q1t
a bond
H
a bond
NH
O
NH
Q3a
OH


380
N
NEt
Q1t
a bond
H
a bond
NH
O
NH
Q3b
OH


381
N
NEt
Q1t
a bond
H
a bond
NH
O
NH
Q3c
OH


382
N
NEt
Q1t
a bond
H
a bond
NH
O
a bond
Q3a
OH


383
N
NEt
Q1t
a bond
H
a bond
NH
O
a bond
Q3b
OH


384
N
NEt
Q1t
a bond
H
a bond
NH
O
a bond
Q3c
OH


385
N
NEt
Q1u
a bond
Me
a bond
NH
S
NH
Q3a
OH


386
N
NEt
Q1u
a bond
Me
a bond
NH
S
NH
Q3b
OH


387
N
NEt
Q1u
a bond
Me
a bond
NH
S
NH
Q3c
OH


388
N
NEt
Q1u
a bond
Me
a bond
NH
S
a bond
Q3a
OH


389
N
NEt
Q1u
a bond
Me
a bond
NH
S
a bond
Q3b
OH


390
N
NEt
Q1u
a bond
Me
a bond
NH
S
a bond
Q3c
OH


391
N
NEt
Q1u
a bond
Me
a bond
NH
O
NH
Q3a
OH


392
N
NEt
Q1u
a bond
Me
a bond
NH
O
NH
Q3b
OH


393
N
NEt
Q1u
a bond
Me
a bond
NH
O
NH
Q3c
OH


394
N
NEt
Q1u
a bond
Me
a bond
NH
O
a bond
Q3a
OH


395
N
NEt
Q1u
a bond
Me
a bond
NH
O
a bond
Q3b
OH


396
N
NEt
Q1u
a bond
Me
a bond
NH
O
a bond
Q3c
OH


397
N
NEt
Q1u
a bond
H
a bond
NH
S
NH
Q3a
OH


398
N
NEt
Q1u
a bond
H
a bond
NH
S
NH
Q3b
OH


399
N
NEt
Q1u
a bond
H
a bond
NH
S
NH
Q3c
OH


400
N
NEt
Q1u
a bond
H
a bond
NH
S
a bond
Q3a
OH


401
N
NEt
Q1u
a bond
H
a bond
NH
S
a bond
Q3b
OH


402
N
NEt
Q1u
a bond
H
a bond
NH
S
a bond
Q3c
OH


403
N
NEt
Q1u
a bond
H
a bond
NH
O
NH
Q3a
OH


404
N
NEt
Q1u
a bond
H
a bond
NH
O
NH
Q3b
OH


405
N
NEt
Q1u
a bond
H
a bond
NH
O
NH
Q3c
OH


406
N
NEt
Q1u
a bond
H
a bond
NH
O
a bond
Q3a
OH


407
N
NEt
Q1u
a bond
H
a bond
NH
O
a bond
Q3b
OH


408
N
NEt
Q1u
a bond
H
a bond
NH
O
a bond
Q3c
OH


409
N
NEt
Q1v
a bond
Me
a bond
NH
S
NH
Q3a
OH


410
N
NEt
Q1v
a bond
Me
a bond
NH
S
NH
Q3b
OH


411
N
NEt
Q1v
a bond
Me
a bond
NH
S
NH
Q3c
OH


412
N
NEt
Q1v
a bond
Me
a bond
NH
S
a bond
Q3a
OH


413
N
NEt
Q1v
a bond
Me
a bond
NH
S
a bond
Q3b
OH


414
N
NEt
Q1v
a bond
Me
a bond
NH
S
a bond
Q3c
OH


415
N
NEt
Q1v
a bond
Me
a bond
NH
O
NH
Q3a
OH


416
N
NEt
Q1v
a bond
Me
a bond
NH
O
NH
Q3b
OH


417
N
NEt
Q1v
a bond
Me
a bond
NH
O
NH
Q3c
OH


418
N
NEt
Q1v
a bond
Me
a bond
NH
O
a bond
Q3a
OH


419
N
NEt
Q1v
a bond
Me
a bond
NH
O
a bond
Q3b
OH


420
N
NEt
Q1v
a bond
Me
a bond
NH
O
a bond
Q3c
OH


421
N
NEt
Q1v
a bond
H
a bond
NH
S
NH
Q3a
OH


422
N
NEt
Q1v
a bond
H
a bond
NH
S
NH
Q3b
OH


423
N
NEt
Q1v
a bond
H
a bond
NH
S
NH
Q3c
OH


424
N
NEt
Q1v
a bond
H
a bond
NH
S
a bond
Q3a
OH


425
N
NEt
Q1v
a bond
H
a bond
NH
S
a bond
Q3b
OH


426
N
NEt
Q1v
a bond
H
a bond
NH
S
a bond
Q3c
OH


427
N
NEt
Q1v
a bond
H
a bond
NH
O
NH
Q3a
OH


428
N
NEt
Q1v
a bond
H
a bond
NH
O
NH
Q3b
OH


429
N
NEt
Q1v
a bond
H
a bond
NH
O
NH
Q3c
OH


430
N
NEt
Q1v
a bond
H
a bond
NH
O
a bond
Q3a
OH


431
N
NEt
Q1v
a bond
H
a bond
NH
O
a bond
Q3b
OH


432
N
NEt
Q1v
a bond
H
a bond
NH
O
a bond
Q3c
OH


433
N
NEt
Q1w
a bond
Me
a bond
NH
S
NH
Q3a
OH


434
N
NEt
Q1w
a bond
Me
a bond
NH
S
NH
Q3b
OH


435
N
NEt
Q1w
a bond
Me
a bond
NH
S
NH
Q3c
OH


436
N
NEt
Q1w
a bond
Me
a bond
NH
S
a bond
Q3a
OH


437
N
NEt
Q1w
a bond
Me
a bond
NH
S
a bond
Q3b
OH


438
N
NEt
Q1w
a bond
Me
a bond
NH
S
a bond
Q3c
OH


439
N
NEt
Q1w
a bond
Me
a bond
NH
O
NH
Q3a
OH


440
N
NEt
Q1w
a bond
Me
a bond
NH
O
NH
Q3b
OH


441
N
NEt
Q1w
a bond
Me
a bond
NH
O
NH
Q3c
OH


442
N
NEt
Q1w
a bond
Me
a bond
NH
O
a bond
Q3a
OH


443
N
NEt
Q1w
a bond
Me
a bond
NH
O
a bond
Q3b
OH


444
N
NEt
Q1w
a bond
Me
a bond
NH
O
a bond
Q3c
OH


445
N
NEt
Q1w
a bond
H
a bond
NH
S
NH
Q3a
OH


446
N
NEt
Q1w
a bond
H
a bond
NH
S
NH
Q3b
OH


447
N
NEt
Q1w
a bond
H
a bond
NH
S
NH
Q3c
OH


448
N
NEt
Q1w
a bond
H
a bond
NH
S
a bond
Q3a
OH


449
N
NEt
Q1w
a bond
H
a bond
NH
S
a bond
Q3b
OH


450
N
NEt
Q1w
a bond
H
a bond
NH
S
a bond
Q3c
OH


451
N
NEt
Q1w
a bond
H
a bond
NH
O
NH
Q3a
OH


452
N
NEt
Q1w
a bond
H
a bond
NH
O
NH
Q3b
OH


453
N
NEt
Q1w
a bond
H
a bond
NH
O
NH
Q3c
OH


454
N
NEt
Q1w
a bond
H
a bond
NH
O
a bond
Q3a
OH


455
N
NEt
Q1w
a bond
H
a bond
NH
O
a bond
Q3b
OH


456
N
NEt
Q1w
a bond
H
a bond
NH
O
a bond
Q3c
OH


457
N
NEt
Q1x
a bond
Me
a bond
NH
S
NH
Q3a
OH


458
N
NEt
Q1x
a bond
Me
a bond
NH
S
NH
Q3b
OH


459
N
NEt
Q1x
a bond
Me
a bond
NH
S
NH
Q3c
OH


460
N
NEt
Q1x
a bond
Me
a bond
NH
S
a bond
Q3a
OH


461
N
NEt
Q1x
a bond
Me
a bond
NH
S
a bond
Q3b
OH


462
N
NEt
Q1x
a bond
Me
a bond
NH
S
a bond
Q3c
OH


463
N
NEt
Q1x
a bond
Me
a bond
NH
O
NH
Q3a
OH


464
N
NEt
Q1x
a bond
Me
a bond
NH
O
NH
Q3b
OH


465
N
NEt
Q1x
a bond
Me
a bond
NH
O
NH
Q3c
OH


466
N
NEt
Q1x
a bond
Me
a bond
NH
O
a bond
Q3a
OH


467
N
NEt
Q1x
a bond
Me
a bond
NH
O
a bond
Q3b
OH


468
N
NEt
Q1x
a bond
Me
a bond
NH
O
a bond
Q3c
OH


469
N
NEt
Q1x
a bond
H
a bond
NH
S
NH
Q3a
OH


470
N
NEt
Q1x
a bond
H
a bond
NH
S
NH
Q3b
OH


471
N
NEt
Q1x
a bond
H
a bond
NH
S
NH
Q3c
OH


472
N
NEt
Q1x
a bond
H
a bond
NH
S
a bond
Q3a
OH


473
N
NEt
Q1x
a bond
H
a bond
NH
S
a bond
Q3b
OH


474
N
NEt
Q1x
a bond
H
a bond
NH
S
a bond
Q3c
OH


475
N
NEt
Q1x
a bond
H
a bond
NH
O
NH
Q3a
OH


476
N
NEt
Q1x
a bond
H
a bond
NH
O
NH
Q3b
OH


477
N
NEt
Q1x
a bond
H
a bond
NH
O
NH
Q3c
OH


478
N
NEt
Q1x
a bond
H
a bond
NH
O
a bond
Q3a
OH


479
N
NEt
Q1x
a bond
H
a bond
NH
O
a bond
Q3b
OH


480
N
NEt
Q1x
a bond
H
a bond
NH
O
a bond
Q3c
OH


481
N
S
Q1o
a bond
Me
a bond
NH
S
NH
Q3a
OH


482
N
S
Q1o
a bond
Me
a bond
NH
S
NH
Q3b
OH


483
N
S
Q1o
a bond
Me
a bond
NH
S
NH
Q3c
OH


484
N
S
Q1o
a bond
Me
a bond
NH
S
a bond
Q3a
OH


485
N
S
Q1o
a bond
Me
a bond
NH
S
a bond
Q3b
OH


486
N
S
Q1o
a bond
Me
a bond
NH
S
a bond
Q3c
OH


487
N
S
Q1o
a bond
Me
a bond
NH
O
NH
Q3a
OH


488
N
S
Q1o
a bond
Me
a bond
NH
O
NH
Q3b
OH


489
N
S
Q1o
a bond
Me
a bond
NH
O
NH
Q3c
OH


490
N
S
Q1o
a bond
Me
a bond
NH
O
a bond
Q3a
OH


491
N
S
Q1o
a bond
Me
a bond
NH
O
a bond
Q3b
OH


492
N
S
Q1o
a bond
Me
a bond
NH
O
a bond
Q3c
OH


493
N
S
Q1o
a bond
H
a bond
NH
S
NH
Q3a
OH


494
N
S
Q1o
a bond
H
a bond
NH
S
NH
Q3b
OH


495
N
S
Q1o
a bond
H
a bond
NH
S
NH
Q3c
OH


496
N
S
Q1o
a bond
H
a bond
NH
S
a bond
Q3a
OH


497
N
S
Q1o
a bond
H
a bond
NH
S
a bond
Q3b
OH


498
N
S
Q1o
a bond
H
a bond
NH
S
a bond
Q3c
OH


499
N
S
Q1o
a bond
H
a bond
NH
O
NH
Q3a
OH


500
N
S
Q1o
a bond
H
a bond
NH
O
NH
Q3b
OH


501
N
S
Q1o
a bond
H
a bond
NH
O
NH
Q3c
OH


502
N
S
Q1o
a bond
H
a bond
NH
O
a bond
Q3a
OH


503
N
S
Q1o
a bond
H
a bond
NH
O
a bond
Q3b
OH


504
N
S
Q1o
a bond
H
a bond
NH
O
a bond
Q3c
OH


505
N
S
Q1p
a bond
Me
a bond
NH
S
NH
Q3a
OH


506
N
S
Q1p
a bond
Me
a bond
NH
S
NH
Q3b
OH


507
N
S
Q1p
a bond
Me
a bond
NH
S
NH
Q3c
OH


508
N
S
Q1p
a bond
Me
a bond
NH
S
a bond
Q3a
OH


509
N
S
Q1p
a bond
Me
a bond
NH
S
a bond
Q3b
OH


510
N
S
Q1p
a bond
Me
a bond
NH
S
a bond
Q3c
OH


511
N
S
Q1p
a bond
Me
a bond
NH
O
NH
Q3a
OH


512
N
S
Q1p
a bond
Me
a bond
NH
O
NH
Q3b
OH


513
N
S
Q1p
a bond
Me
a bond
NH
O
NH
Q3c
OH


514
N
S
Q1p
a bond
Me
a bond
NH
O
a bond
Q3a
OH


515
N
S
Q1p
a bond
Me
a bond
NH
O
a bond
Q3b
OH


516
N
S
Q1p
a bond
Me
a bond
NH
O
a bond
Q3c
OH


517
N
S
Q1p
a bond
H
a bond
NH
S
NH
Q3a
OH


518
N
S
Q1p
a bond
H
a bond
NH
S
NH
Q3b
OH


519
N
S
Q1p
a bond
H
a bond
NH
S
NH
Q3c
OH


520
N
S
Q1p
a bond
H
a bond
NH
S
a bond
Q3a
OH


521
N
S
Q1p
a bond
H
a bond
NH
S
a bond
Q3b
OH


522
N
S
Q1p
a bond
H
a bond
NH
S
a bond
Q3c
OH


523
N
S
Q1p
a bond
H
a bond
NH
O
NH
Q3a
OH


524
N
S
Q1p
a bond
H
a bond
NH
O
NH
Q3b
OH


525
N
S
Q1p
a bond
H
a bond
NH
O
NH
Q3c
OH


526
N
S
Q1p
a bond
H
a bond
NH
O
a bond
Q3a
OH


527
N
S
Q1p
a bond
H
a bond
NH
O
a bond
Q3b
OH


528
N
S
Q1p
a bond
H
a bond
NH
O
a bond
Q3c
OH


529
N
S
Q1q
a bond
Me
a bond
NH
S
NH
Q3a
OH


530
N
S
Q1q
a bond
Me
a bond
NH
S
NH
Q3b
OH


531
N
S
Q1q
a bond
Me
a bond
NH
S
NH
Q3c
OH


532
N
S
Q1q
a bond
Me
a bond
NH
S
a bond
Q3a
OH


533
N
S
Q1q
a bond
Me
a bond
NH
S
a bond
Q3b
OH


534
N
S
Q1q
a bond
Me
a bond
NH
S
a bond
Q3c
OH


535
N
S
Q1q
a bond
Me
a bond
NH
O
NH
Q3a
OH


536
N
S
Q1q
a bond
Me
a bond
NH
O
NH
Q3b
OH


537
N
S
Q1q
a bond
Me
a bond
NH
O
NH
Q3c
OH


538
N
S
Q1q
a bond
Me
a bond
NH
O
a bond
Q3a
OH


539
N
S
Q1q
a bond
Me
a bond
NH
O
a bond
Q3b
OH


540
N
S
Q1q
a bond
Me
a bond
NH
O
a bond
Q3c
OH


541
N
S
Q1q
a bond
H
a bond
NH
S
NH
Q3a
OH


542
N
S
Q1q
a bond
H
a bond
NH
S
NH
Q3b
OH


543
N
S
Q1q
a bond
H
a bond
NH
S
NH
Q3c
OH


544
N
S
Q1q
a bond
H
a bond
NH
S
a bond
Q3a
OH


545
N
S
Q1q
a bond
H
a bond
NH
S
a bond
Q3b
OH


546
N
S
Q1q
a bond
H
a bond
NH
S
a bond
Q3c
OH


547
N
S
Q1q
a bond
H
a bond
NH
O
NH
Q3a
OH


548
N
S
Q1q
a bond
H
a bond
NH
O
NH
Q3b
OH


549
N
S
Q1q
a bond
H
a bond
NH
O
NH
Q3c
OH


550
N
S
Q1q
a bond
H
a bond
NH
O
a bond
Q3a
OH


551
N
S
Q1q
a bond
H
a bond
NH
O
a bond
Q3b
OH


552
N
S
Q1q
a bond
H
a bond
NH
O
a bond
Q3c
OH


553
N
S
Q1r
a bond
Me
a bond
NH
S
NH
Q3a
OH


554
N
S
Q1r
a bond
Me
a bond
NH
S
NH
Q3b
OH


555
N
S
Q1r
a bond
Me
a bond
NH
S
NH
Q3c
OH


556
N
S
Q1r
a bond
Me
a bond
NH
S
a bond
Q3a
OH


557
N
S
Q1r
a bond
Me
a bond
NH
S
a bond
Q3b
OH


558
N
S
Q1r
a bond
Me
a bond
NH
S
a bond
Q3c
OH


559
N
S
Q1r
a bond
Me
a bond
NH
O
NH
Q3a
OH


560
N
S
Q1r
a bond
Me
a bond
NH
O
NH
Q3b
OH


561
N
S
Q1r
a bond
Me
a bond
NH
O
NH
Q3c
OH


562
N
S
Q1r
a bond
Me
a bond
NH
O
a bond
Q3a
OH


563
N
S
Q1r
a bond
Me
a bond
NH
O
a bond
Q3b
OH


564
N
S
Q1r
a bond
Me
a bond
NH
O
a bond
Q3c
OH


565
N
S
Q1r
a bond
H
a bond
NH
S
NH
Q3a
OH


566
N
S
Q1r
a bond
H
a bond
NH
S
NH
Q3b
OH


567
N
S
Q1r
a bond
H
a bond
NH
S
NH
Q3c
OH


568
N
S
Q1r
a bond
H
a bond
NH
S
a bond
Q3a
OH


569
N
S
Q1r
a bond
H
a bond
NH
S
a bond
Q3b
OH


570
N
S
Q1r
a bond
H
a bond
NH
S
a bond
Q3c
OH


571
N
S
Q1r
a bond
H
a bond
NH
O
NH
Q3a
OH


572
N
S
Q1r
a bond
H
a bond
NH
O
NH
Q3b
OH


573
N
S
Q1r
a bond
H
a bond
NH
O
NH
Q3c
OLI


574
N
S
Q1r
a bond
H
a bond
NH
O
a bond
Q3a
OH


575
N
S
Q1r
a bond
H
a bond
NH
O
a bond
Q3b
OH


576
N
S
Q1r
a bond
H
a bond
NH
O
a bond
Q3c
OH


577
N
S
Q1s
a bond
Me
a bond
NH
S
NH
Q3a
OH


578
N
S
Q1s
a bond
Me
a bond
NH
S
NH
Q3b
OH


579
N
S
Q1s
a bond
Me
a bond
NH
S
NH
Q3c
OH


580
N
S
Q1s
a bond
Me
a bond
NH
S
a bond
Q3a
OH


581
N
S
Q1s
a bond
Me
a bond
NH
S
a bond
Q3b
OH


582
N
S
Q1s
a bond
Me
a bond
NH
S
a bond
Q3c
OH


583
N
S
Q1s
a bond
Me
a bond
NH
O
NH
Q3a
OH


584
N
S
Q1s
a bond
Me
a bond
NH
O
NH
Q3b
OH


585
N
S
Q1s
a bond
Me
a bond
NH
O
NH
Q3c
OH


586
N
S
Q1s
a bond
Me
a bond
NH
O
a bond
Q3a
OH


587
N
S
Q1s
a bond
Me
a bond
NH
O
a bond
Q3b
OH


588
N
S
Q1s
a bond
Me
a bond
NH
O
a bond
Q3c
OH


589
N
S
Q1s
a bond
H
a bond
NH
S
NH
Q3a
OH


590
N
S
Q1s
a bond
H
a bond
NH
S
NH
Q3b
OH


591
N
S
Q1s
a bond
H
a bond
NH
S
NH
Q3c
OH


592
N
S
Q1s
a bond
H
a bond
NH
S
a bond
Q3a
OH


593
N
S
Q1s
a bond
H
a bond
NH
S
a bond
Q3b
OH


594
N
S
Q1s
a bond
H
a bond
NH
S
a bond
Q3c
OH


595
N
S
Q1s
a bond
H
a bond
NH
O
NH
Q3a
OH


596
N
S
Q1s
a bond
H
a bond
NH
O
NH
Q3b
OH


597
N
S
Q1s
a bond
H
a bond
NH
O
NH
Q3c
OH


598
N
S
Q1s
a bond
H
a bond
NH
O
a bond
Q3a
OH


599
N
S
Q1s
a bond
H
a bond
NH
O
a bond
Q3b
OH


600
N
S
Q1s
a bond
H
a bond
NH
O
a bond
Q3c
OH


601
N
S
Q1t
a bond
Me
a bond
NH
S
NH
Q3a
OH


602
N
S
Q1t
a bond
Me
a bond
NH
S
NH
Q3b
OH


603
N
S
Q1t
a bond
Me
a bond
NH
S
NH
Q3c
OH


604
N
S
Q1t
a bond
Me
a bond
NH
S
a bond
Q3a
OH


605
N
S
Q1t
a bond
Me
a bond
NH
S
a bond
Q3b
OH


606
N
S
Q1t
a bond
Me
a bond
NH
S
a bond
Q3c
OH


607
N
S
Q1t
a bond
Me
a bond
NH
O
NH
Q3a
OH


608
N
S
Q1t
a bond
Me
a bond
NH
O
NH
Q3b
OH


609
N
S
Q1t
a bond
Me
a bond
NH
O
NH
Q3c
OH


610
N
S
Q1t
a bond
Me
a bond
NH
O
a bond
Q3a
OH


611
N
S
Q1t
a bond
Me
a bond
NH
O
a bond
Q3b
OH


612
N
S
Q1t
a bond
Me
a bond
NH
O
a bond
Q3c
OH


613
N
S
Q1t
a bond
H
a bond
NH
S
NH
Q3a
OH


614
N
S
Q1t
a bond
H
a bond
NH
S
NH
Q3b
OH


615
N
S
Q1t
a bond
H
a bond
NH
S
NH
Q3c
OH


616
N
S
Q1t
a bond
H
a bond
NH
S
a bond
Q3a
OH


617
N
S
Q1t
a bond
H
a bond
NH
S
a bond
Q3b
OH


618
N
S
Q1t
a bond
H
a bond
NH
S
a bond
Q3c
OH


619
N
S
Q1t
a bond
H
a bond
NH
O
NH
Q3a
OH


620
N
S
Q1t
a bond
H
a bond
NH
O
NH
Q3b
OH


621
N
S
Q1t
a bond
H
a bond
NH
O
NH
Q3c
OH


622
N
S
Q1t
a bond
H
a bond
NH
O
a bond
Q3a
OH


623
N
S
Q1t
a bond
H
a bond
NH
O
a bond
Q3b
OH


624
N
S
Q1t
a bond
H
a bond
NH
O
a bond
Q3c
OH


625
N
S
Q1u
a bond
Me
a bond
NH
S
NH
Q3a
OH


626
N
S
Q1u
a bond
Me
a bond
NH
S
NH
Q3b
OH


627
N
S
Q1u
a bond
Me
a bond
NH
S
NH
Q3c
OH


628
N
S
Q1u
a bond
Me
a bond
NH
S
a bond
Q3a
OH


629
N
S
Q1u
a bond
Me
a bond
NH
S
a bond
Q3b
OH


630
N
S
Q1u
a bond
Me
a bond
NH
S
a bond
Q3c
OH


631
N
S
Q1u
a bond
Me
a bond
NH
O
NH
Q3a
OH


632
N
S
Q1u
a bond
Me
a bond
NH
O
NH
Q3b
OH


633
N
S
Q1u
a bond
Me
a bond
NH
O
NH
Q3c
OH


634
N
S
Q1u
a bond
Me
a bond
NH
O
a bond
Q3a
OH


635
N
S
Q1u
a bond
Me
a bond
NH
O
a bond
Q3b
OH


636
N
S
Q1u
a bond
Me
a bond
NH
O
a bond
Q3c
OH


637
N
S
Q1u
a bond
H
a bond
NH
S
NH
Q3a
OH


638
N
S
Q1u
a bond
H
a bond
NH
S
NH
Q3b
OH


639
N
S
Q1u
a bond
H
a bond
NH
S
NH
Q3c
OH


640
N
S
Q1u
a bond
H
a bond
NH
S
a bond
Q3a
OH


641
N
S
Q1u
a bond
H
a bond
NH
S
a bond
Q3b
OH


642
N
S
Q1u
a bond
H
a bond
NH
S
a bond
Q3c
OH


643
N
S
Q1u
a bond
H
a bond
NH
O
NH
Q3a
OH


644
N
S
Q1u
a bond
H
a bond
NH
O
NH
Q3b
OH


645
N
S
Q1u
a bond
H
a bond
NH
O
NH
Q3c
OH


646
N
S
Q1u
a bond
H
a bond
NH
O
a bond
Q3a
OH


647
N
S
Q1u
a bond
H
a bond
NH
O
a bond
Q3b
OH


648
N
S
Q1u
a bond
H
a bond
NH
O
a bond
Q3c
OH


649
N
S
Q1v
a bond
Me
a bond
NH
S
NH
Q3a
OH


650
N
S
Q1v
a bond
Me
a bond
NH
S
NH
Q3b
OH


651
N
S
Q1v
a bond
Me
a bond
NH
S
NH
Q3c
OH


652
N
S
Q1v
a bond
Me
a bond
NH
S
a bond
Q3a
OH


653
N
S
Q1v
a bond
Me
a bond
NH
S
a bond
Q3b
OH


654
N
S
Q1v
a bond
Me
a bond
NH
S
a bond
Q3c
OH


655
N
S
Q1v
a bond
Me
a bond
NH
O
NH
Q3a
OH


656
N
S
Q1v
a bond
Me
a bond
NH
O
NH
Q3b
OH


657
N
S
Q1v
a bond
Me
a bond
NH
O
NH
Q3c
OH


658
N
S
Q1v
a bond
Me
a bond
NH
O
a bond
Q3a
OH


659
N
S
Q1v
a bond
Me
a bond
NH
O
a bond
Q3b
OH


660
N
S
Q1v
a bond
Me
a bond
NH
O
a bond
Q3c
OH


661
N
S
Q1v
a bond
H
a bond
NH
S
NH
Q3a
OH


662
N
S
Q1v
a bond
H
a bond
NH
S
NH
Q3b
OH


663
N
S
Q1v
a bond
H
a bond
NH
S
NH
Q3c
OH


664
N
S
Q1v
a bond
H
a bond
NH
S
a bond
Q3a
OH


665
N
S
Q1v
a bond
H
a bond
NH
S
a bond
Q3b
OH


666
N
S
Q1v
a bond
H
a bond
NH
S
a bond
Q3c
OH


667
N
S
Q1v
a bond
H
a bond
NH
O
NH
Q3a
OH


668
N
S
Q1v
a bond
H
a bond
NH
O
NH
Q3b
OH


669
N
S
Q1v
a bond
H
a bond
NH
O
NH
Q3c
OH


670
N
S
Q1v
a bond
H
a bond
NH
O
a bond
Q3a
OH


671
N
S
Q1v
a bond
H
a bond
NH
O
a bond
Q3b
OH


672
N
S
Q1v
a bond
H
a bond
NH
O
a bond
Q3c
OH


673
N
S
Q1w
a bond
Me
a bond
NH
S
NH
Q3a
OH


674
N
S
Q1w
a bond
Me
a bond
NH
S
NH
Q3b
OH


675
N
S
Q1w
a bond
Me
a bond
NH
S
NH
Q3c
OH


676
N
S
Q1w
a bond
Me
a bond
NH
S
a bond
Q3a
OH


677
N
S
Q1w
a bond
Me
a bond
NH
S
a bond
Q3b
OH


678
N
S
Q1w
a bond
Me
a bond
NH
S
a bond
Q3c
OH


679
N
S
Q1w
a bond
Me
a bond
NH
O
NH
Q3a
OH


680
N
S
Q1w
a bond
Me
a bond
NH
O
NH
Q3b
OH


681
N
S
Q1w
a bond
Me
a bond
NH
O
NH
Q3c
OH


682
N
S
Q1w
a bond
Me
a bond
NH
O
a bond
Q3a
OH


683
N
S
Q1w
a bond
Me
a bond
NH
O
a bond
Q3b
OH


684
N
S
Q1w
a bond
Me
a bond
NH
O
a bond
Q3c
OH


685
N
S
Q1w
a bond
H
a bond
NH
S
NH
Q3a
OH


686
N
S
Q1w
a bond
H
a bond
NH
S
NH
Q3b
OH


687
N
S
Q1w
a bond
H
a bond
NH
S
NH
Q3c
OH


688
N
S
Q1w
a bond
H
a bond
NH
S
a bond
Q3a
OH


689
N
S
Q1w
a bond
H
a bond
NH
S
a bond
Q3b
OH


690
N
S
Q1w
a bond
H
a bond
NH
S
a bond
Q3c
OH


691
N
S
Q1w
a bond
H
a bond
NH
O
NH
Q3a
OH


692
N
S
Q1w
a bond
H
a bond
NH
O
NH
Q3b
OH


693
N
S
Q1w
a bond
H
a bond
NH
O
NH
Q3c
OH


694
N
S
Q1w
a bond
H
a bond
NH
O
a bond
Q3a
OH


695
N
S
Q1w
a bond
H
a bond
NH
O
a bond
Q3b
OH


696
N
S
Q1w
a bond
H
a bond
NH
O
a bond
Q3c
OH


697
N
S
Q1x
a bond
Me
a bond
NH
S
NH
Q3a
OH


698
N
S
Q1x
a bond
Me
a bond
NH
S
NH
Q3b
OH


699
N
S
Q1x
a bond
Me
a bond
NH
S
NH
Q3c
OH


700
N
S
Q1x
a bond
Me
a bond
NH
S
a bond
Q3a
OH


701
N
S
Q1x
a bond
Me
a bond
NH
S
a bond
Q3b
OH


702
N
S
Q1x
a bond
Me
a bond
NH
S
a bond
Q3c
OH


703
N
S
Q1x
a bond
Me
a bond
NH
O
NH
Q3a
OH


704
N
S
Q1x
a bond
Me
a bond
NH
O
NH
Q3b
OH


705
N
S
Q1x
a bond
Me
a bond
NH
O
NH
Q3c
OH


706
N
S
Q1x
a bond
Me
a bond
NH
O
a bond
Q3a
OH


707
N
S
Q1x
a bond
Me
a bond
NH
O
a bond
Q3b
OH


708
N
S
Q1x
a bond
Me
a bond
NH
O
a bond
Q3c
OH


709
N
S
Q1x
a bond
H
a bond
NH
S
NH
Q3a
OH


710
N
S
Q1x
a bond
H
a bond
NH
S
NH
Q3b
OH


711
N
S
Q1x
a bond
H
a bond
NH
S
NH
Q3c
OH


712
N
S
Q1x
a bond
H
a bond
NH
S
a bond
Q3a
OH


713
N
S
Q1x
a bond
H
a bond
NH
S
a bond
Q3b
OH


714
N
S
Q1x
a bond
H
a bond
NH
S
a bond
Q3c
OH


715
N
S
Q1x
a bond
H
a bond
NH
O
NH
Q3a
OH


716
N
S
Q1x
a bond
H
a bond
NH
O
NH
Q3b
OH


717
N
S
Q1x
a bond
H
a bond
NH
O
NH
Q3c
OH


718
N
S
Q1x
a bond
H
a bond
NH
O
a bond
Q3a
OH


719
N
S
Q1x
a bond
H
a bond
NH
O
a bond
Q3b
OH


720
N
S
Q1x
a bond
H
a bond
NH
O
a bond
Q3c
OH


721
N
O
Q1o
a bond
Me
a bond
NH
S
NH
Q3a
OH


722
N
O
Q1o
a bond
Me
a bond
NH
S
NH
Q3b
OH


723
N
O
Q1o
a bond
Me
a bond
NH
S
NH
Q3c
OH


724
N
O
Q1o
a bond
Me
a bond
NH
S
a bond
Q3a
OH


725
N
O
Q1o
a bond
Me
a bond
NH
S
a bond
Q3b
OH


726
N
O
Q1o
a bond
Me
a bond
NH
S
a bond
Q3c
OH


727
N
O
Q1o
a bond
Me
a bond
NH
O
NH
Q3a
OH


728
N
O
Q1o
a bond
Me
a bond
NH
O
NH
Q3b
OH


729
N
O
Q1o
a bond
Me
a bond
NH
O
NH
Q3c
OH


730
N
O
Q1o
a bond
Me
a bond
NH
O
a bond
Q3a
OH


731
N
O
Q1o
a bond
Me
a bond
NH
O
a bond
Q3b
OH


732
N
O
Q1o
a bond
Me
a bond
NH
O
a bond
Q3c
OH


733
N
O
Q1o
a bond
H
a bond
NH
S
NH
Q3a
OH


734
N
O
Q1o
a bond
H
a bond
NH
S
NH
Q3b
OH


735
N
O
Q1o
a bond
H
a bond
NH
S
NH
Q3c
OH


736
N
O
Q1o
a bond
H
a bond
NH
S
a bond
Q3a
OH


737
N
O
Q1o
a bond
H
a bond
NH
S
a bond
Q3b
OH


738
N
O
Q1o
a bond
H
a bond
NH
S
a bond
Q3c
OH


739
N
O
Q1o
a bond
H
a bond
NH
O
NH
Q3a
OH


740
N
O
Q1o
a bond
H
a bond
NH
O
NH
Q3b
OH


741
N
O
Q1o
a bond
H
a bond
NH
O
NH
Q3c
OH


742
N
O
Q1o
a bond
H
a bond
NH
O
a bond
Q3a
OH


743
N
O
Q1o
a bond
H
a bond
NH
O
a bond
Q3b
OH


744
N
O
Q1o
a bond
H
a bond
NH
O
a bond
Q3c
OH


745
N
O
Q1p
a bond
Me
a bond
NH
S
NH
Q3a
OH


746
N
O
Q1p
a bond
Me
a bond
NH
S
NH
Q3b
OH


747
N
O
Q1p
a bond
Me
a bond
NH
S
NH
Q3c
OH


748
N
O
Q1p
a bond
Me
a bond
NH
S
a bond
Q3a
OH


749
N
O
Q1p
a bond
Me
a bond
NH
S
a bond
Q3b
OH


750
N
O
Q1p
a bond
Me
a bond
NH
S
a bond
Q3c
OH


751
N
O
Q1p
a bond
Me
a bond
NH
O
NH
Q3a
OH


752
N
O
Q1p
a bond
Me
a bond
NH
O
NH
Q3b
OH


753
N
O
Q1p
a bond
Me
a bond
NH
O
NH
Q3c
OH


754
N
O
Q1p
a bond
Me
a bond
NH
O
a bond
Q3a
OH


755
N
O
Q1p
a bond
Me
a bond
NH
O
a bond
Q3b
OH


756
N
O
Q1p
a bond
Me
a bond
NH
O
a bond
Q3c
OH


757
N
O
Q1p
a bond
H
a bond
NH
S
NH
Q3a
OH


758
N
O
Q1p
a bond
H
a bond
NH
S
NH
Q3b
OH


759
N
O
Q1p
a bond
H
a bond
NH
S
NH
Q3c
OH


760
N
O
Q1p
a bond
H
a bond
NH
S
a bond
Q3a
OH


761
N
O
Q1p
a bond
H
a bond
NH
S
a bond
Q3b
OH


762
N
O
Q1p
a bond
H
a bond
NH
S
a bond
Q3c
OH


763
N
O
Q1p
a bond
H
a bond
NH
O
NH
Q3a
OH


764
N
O
Q1p
a bond
H
a bond
NH
O
NH
Q3b
OH


765
N
O
Q1p
a bond
H
a bond
NH
O
NH
Q3c
OH


766
N
O
Q1p
a bond
H
a bond
NH
O
a bond
Q3a
OH


767
N
O
Q1p
a bond
H
a bond
NH
O
a bond
Q3b
OH


768
N
O
Q1p
a bond
H
a bond
NH
O
a bond
Q3c
OH


769
N
O
Q1q
a bond
Me
a bond
NH
S
NH
Q3a
OH


770
N
O
Q1q
a bond
Me
a bond
NH
S
NH
Q3b
OH


771
N
O
Q1q
a bond
Me
a bond
NH
S
NH
Q3c
OH


772
N
O
Q1q
a bond
Me
a bond
NH
S
a bond
Q3a
OH


773
N
O
Q1q
a bond
Me
a bond
NH
S
a bond
Q3b
OH


774
N
O
Q1p
a bond
Me
a bond
NH
S
a bond
Q3c
OH


775
N
O
Q1q
a bond
Me
a bond
NH
O
NH
Q3a
OH


776
N
O
Q1q
a bond
Me
a bond
NH
O
NH
Q3b
OH


777
N
O
Q1q
a bond
Me
a bond
NH
O
NH
Q3c
OH


778
N
O
Q1q
a bond
Me
a bond
NH
O
a bond
Q3a
OH


779
N
O
Q1q
a bond
Me
a bond
NH
O
a bond
Q3b
OH


780
N
O
Q1q
a bond
Me
a bond
NH
O
a bond
Q3c
OH


781
N
O
Q1q
a bond
H
a bond
NH
S
NH
Q3a
OH


782
N
O
Q1q
a bond
H
a bond
NH
S
NH
Q3b
OH


783
N
O
Q1q
a bond
H
a bond
NH
S
NH
Q3c
OH


784
N
O
Q1q
a bond
H
a bond
NH
S
a bond
Q3a
OH


785
N
O
Q1q
a bond
H
a bond
NH
S
a bond
Q3b
OH


786
N
O
Q1q
a bond
H
a bond
NH
S
a bond
Q3c
OH


787
N
O
Q1q
a bond
H
a bond
NH
O
NH
Q3a
OH


788
N
O
Q1q
a bond
H
a bond
NH
O
NH
Q3b
OH


789
N
O
Q1q
a bond
H
a bond
NH
O
NH
Q3c
OH


790
N
O
Q1q
a bond
H
a bond
NH
O
a bond
Q3a
OH


791
N
O
Q1q
a bond
H
a bond
NH
O
a bond
Q3b
OH


792
N
O
Q1q
a bond
H
a bond
NH
O
a bond
Q3c
OH


793
N
O
Q1r
a bond
Me
a bond
NH
S
NH
Q3a
OH


794
N
O
Q1r
a bond
Me
a bond
NH
S
NH
Q3b
OH


795
N
O
Q1r
a bond
Me
a bond
NH
S
NH
Q3c
OH


796
N
O
Q1r
a bond
Me
a bond
NH
S
a bond
Q3a
OH


797
N
O
Q1r
a bond
Me
a bond
NH
S
a bond
Q3b
OH


798
N
O
Q1r
a bond
Me
a bond
NH
S
a bond
Q3c
OH


799
N
O
Q1r
a bond
Me
a bond
NH
O
NH
Q3a
OH


800
N
O
Q1r
a bond
Me
a bond
NH
O
NH
Q3b
OH


801
N
O
Q1r
a bond
Me
a bond
NH
O
NH
Q3c
OH


802
N
O
Q1r
a bond
Me
a bond
NH
O
a bond
Q3a
OH


803
N
O
Q1r
a bond
Me
a bond
NH
O
a bond
Q3b
OH


804
N
O
Q1r
a bond
Me
a bond
NH
O
a bond
Q3c
OH


805
N
O
Q1r
a bond
H
a bond
NH
S
NH
Q3a
OH


806
N
O
Q1r
a bond
H
a bond
NH
S
NH
Q3b
OH


807
N
O
Q1r
a bond
H
a bond
NH
S
NH
Q3c
OH


808
N
O
Q1r
a bond
H
a bond
NH
S
a bond
Q3a
OH


809
N
O
Q1r
a bond
H
a bond
NH
S
a bond
Q3b
OH


810
N
O
Q1r
a bond
H
a bond
NH
S
a bond
Q3c
OH


811
N
O
Q1r
a bond
H
a bond
NH
O
NH
Q3a
OH


812
N
O
Q1r
a bond
H
a bond
NH
O
NH
Q3b
OH


813
N
O
Q1r
a bond
H
a bond
NH
O
NH
Q3c
OH


814
N
O
Q1r
a bond
H
a bond
NH
O
a bond
Q3a
OH


815
N
O
Q1r
a bond
H
a bond
NH
O
a bond
Q3b
OH


816
N
O
Q1r
a bond
H
a bond
NH
O
a bond
Q3c
OH


817
N
O
Q1s
a bond
Me
a bond
NH
S
NH
Q3a
OH


818
N
O
Q1s
a bond
Me
a bond
NH
S
NH
Q3b
OH


819
N
O
Q1s
a bond
Me
a bond
NH
S
NH
Q3c
OH


820
N
O
Q1s
a bond
Me
a bond
NH
S
a bond
Q3a
OH


821
N
O
Q1s
a bond
Me
a bond
NH
S
a bond
Q3b
OH


822
N
O
Q1s
a bond
Me
a bond
NH
S
a bond
Q3c
OH


823
N
O
Q1s
a bond
Me
a bond
NH
O
NH
Q3a
OH


824
N
O
Q1s
a bond
Me
a bond
NH
O
NH
Q3b
OH


825
N
O
Q1s
a bond
Me
a bond
NH
O
NH
Q3c
OH


826
N
O
Q1s
a bond
Me
a bond
NH
O
a bond
Q3a
OH


827
N
O
Q1s
a bond
Me
a bond
NH
O
a bond
Q3b
OH


828
N
O
Q1s
a bond
Me
a bond
NH
O
a bond
Q3c
OH


829
N
O
Q1s
a bond
H
a bond
NH
S
NH
Q3a
OH


830
N
O
Q1s
a bond
H
a bond
NH
S
NH
Q3b
OH


831
N
O
Q1s
a bond
H
a bond
NH
S
NH
Q3c
OH


832
N
O
Q1s
a bond
H
a bond
NH
S
a bond
Q3a
OH


833
N
O
Q1s
a bond
H
a bond
NH
S
a bond
Q3b
OH


834
N
O
Q1s
a bond
H
a bond
NH
S
a bond
Q3c
OH


835
N
O
Q1s
a bond
H
a bond
NH
O
NH
Q3a
OH


836
N
O
Q1s
a bond
H
a bond
NH
O
NH
Q3b
OH


837
N
O
Q1s
a bond
H
a bond
NH
O
NH
Q3c
OH


838
N
O
Q1s
a bond
H
a bond
NH
O
a bond
Q3a
OH


839
N
O
Q1s
a bond
H
a bond
NH
O
a bond
Q3b
OH


840
N
O
Q1s
a bond
H
a bond
NH
O
a bond
Q3c
OH


841
N
O
Q1t
a bond
Me
a bond
NH
S
NH
Q3a
OH


842
N
O
Q1t
a bond
Me
a bond
NH
S
NH
Q3b
OH


843
N
O
Q1t
a bond
Me
a bond
NH
S
NH
Q3c
OH


844
N
O
Q1t
a bond
Me
a bond
NH
S
a bond
Q3a
OH


845
N
O
Q1t
a bond
Me
a bond
NH
S
a bond
Q3b
OH


846
N
O
Q1t
a bond
Me
a bond
NH
S
a bond
Q3c
OH


847
N
O
Q1t
a bond
Me
a bond
NH
O
NH
Q3a
OH


848
N
O
Q1t
a bond
Me
a bond
NH
O
NH
Q3b
OH


849
N
O
Q1t
a bond
Me
a bond
NH
O
NH
Q3c
OH


850
N
O
Q1t
a bond
Me
a bond
NH
O
a bond
Q3a
OH


851
N
O
Q1t
a bond
Me
a bond
NH
O
a bond
Q3b
OH


852
N
O
Q1t
a bond
Me
a bond
NH
O
a bond
Q3c
OH


853
N
O
Q1t
a bond
H
a bond
NH
S
NH
Q3a
OH


854
N
O
Q1t
a bond
H
a bond
NH
S
NH
Q3b
OH


855
N
O
Q1t
a bond
H
a bond
NH
S
NH
Q3c
OH


856
N
O
Q1t
a bond
H
a bond
NH
S
a bond
Q3a
OH


857
N
O
Q1t
a bond
H
a bond
NH
S
a bond
Q3b
OH


858
N
O
Q1t
a bond
H
a bond
NH
S
a bond
Q3c
OH


859
N
O
Q1t
a bond
H
a bond
NH
O
NH
Q3a
OH


860
N
O
Q1t
a bond
H
a bond
NH
O
NH
Q3b
OH


861
N
O
Q1t
a bond
H
a bond
NH
O
NH
Q3c
OH


862
N
O
Q1t
a bond
H
a bond
NH
O
a bond
Q3a
OH


863
N
O
Q1t
a bond
H
a bond
NH
O
a bond
Q3b
OH


864
N
O
Q1t
a bond
H
a bond
NH
O
a bond
Q3c
OH


865
N
O
Q1u
a bond
Me
a bond
NH
S
NH
Q3a
OH


866
N
O
Q1u
a bond
Me
a bond
NH
S
NH
Q3b
OH


867
N
O
Q1u
a bond
Me
a bond
NH
S
NH
Q3c
OH


868
N
O
Q1u
a bond
Me
a bond
NH
S
a bond
Q3a
OH


869
N
O
Q1u
a bond
Me
a bond
NH
S
a bond
Q3b
OH


870
N
O
Q1u
a bond
Me
a bond
NH
S
a bond
Q3c
OH


871
N
O
Q1u
a bond
Me
a bond
NH
O
NH
Q3a
OH


872
N
O
Q1u
a bond
Me
a bond
NH
O
NH
Q3b
OH


873
N
O
Q1u
a bond
Me
a bond
NH
O
NH
Q3c
OH


874
N
O
Q1u
a bond
Me
a bond
NH
O
a bond
Q3a
OH


875
N
O
Q1u
a bond
Me
a bond
NH
O
a bond
Q3b
OH


876
N
O
Q1u
a bond
Me
a bond
NH
O
a bond
Q3c
OH


877
N
O
Q1u
a bond
H
a bond
NH
S
NH
Q3a
OH


878
N
O
Q1u
a bond
H
a bond
NH
S
NH
Q3b
OH


879
N
O
Q1u
a bond
H
a bond
NH
S
NH
Q3c
OH


880
N
O
Q1u
a bond
H
a bond
NH
S
a bond
Q3a
OH


881
N
O
Q1u
a bond
H
a bond
NH
S
a bond
Q3b
OH


882
N
O
Q1u
a bond
H
a bond
NH
S
a bond
Q3c
OH


883
N
O
Q1u
a bond
H
a bond
NH
O
NH
Q3a
OH


884
N
O
Q1u
a bond
H
a bond
NH
O
NH
Q3b
OH


885
N
O
Q1u
a bond
H
a bond
NH
O
NH
Q3c
OH


886
N
O
Q1u
a bond
H
a bond
NH
O
a bond
Q3a
OH


887
N
O
Q1u
a bond
H
a bond
NH
O
a bond
Q3b
OH


888
N
O
Q1u
a bond
H
a bond
NH
O
a bond
Q3c
OH


889
N
O
Q1v
a bond
Me
a bond
NH
S
NH
Q3a
OH


890
N
O
Q1v
a bond
Me
a bond
NH
S
NH
Q3b
OH


891
N
O
Q1v
a bond
Me
a bond
NH
S
NH
Q3c
OH


892
N
O
Q1v
a bond
Me
a bond
NH
S
a bond
Q3a
OH


893
N
O
Q1v
a bond
Me
a bond
NH
S
a bond
Q3b
OH


894
N
O
Q1v
a bond
Me
a bond
NH
S
a bond
Q3c
OH


895
N
O
Q1v
a bond
Me
a bond
NH
O
NH
Q3a
OH


896
N
O
Q1v
a bond
Me
a bond
NH
O
NH
Q3b
OH


897
N
O
Q1v
a bond
Me
a bond
NH
O
NH
Q3c
OH


898
N
O
Q1v
a bond
Me
a bond
NH
O
a bond
Q3a
OH


899
N
O
Q1v
a bond
Me
a bond
NH
O
a bond
Q3b
OH


900
N
O
Q1v
a bond
Me
a bond
NH
O
a bond
Q3c
OH


901
N
O
Q1v
a bond
H
a bond
NH
S
NH
Q3a
OH


902
N
O
Q1v
a bond
H
a bond
NH
S
NH
Q3b
OH


903
N
O
Q1v
a bond
H
a bond
NH
S
NH
Q3c
OH


904
N
O
Q1v
a bond
H
a bond
NH
S
a bond
Q3a
OH


905
N
O
Q1v
a bond
H
a bond
NH
S
a bond
Q3b
OH


906
N
O
Q1v
a bond
H
a bond
NH
S
a bond
Q3c
OH


907
N
O
Q1v
a bond
H
a bond
NH
O
NH
Q3a
OH


908
N
O
Q1v
a bond
H
a bond
NH
O
NH
Q3b
OH


909
N
O
Q1v
a bond
H
a bond
NH
O
NH
Q3c
OH


910
N
O
Q1v
a bond
H
a bond
NH
O
a bond
Q3a
OH


911
N
O
Q1v
a bond
H
a bond
NH
O
a bond
Q3b
OH


912
N
O
Q1v
a bond
H
a bond
NH
O
a bond
Q3c
OH


913
N
O
Q1w
a bond
Me
a bond
NH
S
NH
Q3a
OH


914
N
O
Q1w
a bond
Me
a bond
NH
S
NH
Q3b
OH


915
N
O
Q1w
a bond
Me
a bond
NH
S
NH
Q3c
OH


916
N
O
Q1w
a bond
Me
a bond
NH
S
a bond
Q3a
OH


917
N
O
Q1w
a bond
Me
a bond
NH
S
a bond
Q3b
OH


918
N
O
Q1w
a bond
Me
a bond
NH
S
a bond
Q3c
OH


919
N
O
Q1w
a bond
Me
a bond
NH
O
NH
Q3a
OH


920
N
O
Q1w
a bond
Me
a bond
NH
O
NH
Q3b
OH


921
N
O
Q1w
a bond
Me
a bond
NH
O
NH
Q3c
OH


922
N
O
Q1w
a bond
Me
a bond
NH
O
a bond
Q3a
OH


923
N
O
Q1w
a bond
Me
a bond
NH
O
a bond
Q3b
OH


924
N
O
Q1w
a bond
Me
a bond
NH
O
a bond
Q3c
OH


925
N
O
Q1w
a bond
H
a bond
NH
S
NH
Q3a
OH


926
N
O
Q1w
a bond
H
a bond
NH
S
NH
Q3b
OH


927
N
O
Q1w
a bond
H
a bond
NH
S
NH
Q3c
OH


928
N
O
Q1w
a bond
H
a bond
NH
S
a bond
Q3a
OH


929
N
O
Q1w
a bond
H
a bond
NH
S
a bond
Q3b
OH


930
N
O
Q1w
a bond
H
a bond
NH
S
a bond
Q3c
OH


931
N
O
Q1w
a bond
H
a bond
NH
O
NH
Q3a
OH


932
N
O
Q1w
a bond
H
a bond
NH
O
NH
Q3b
OH


933
N
O
Q1w
a bond
H
a bond
NH
O
NH
Q3c
OH


934
N
O
Q1w
a bond
H
a bond
NH
O
a bond
Q3a
OH


935
N
O
Q1w
a bond
H
a bond
NH
O
a bond
Q3b
OH


936
N
O
Q1w
a bond
H
a bond
NH
O
a bond
Q3c
OH


937
N
O
Q1x
a bond
Me
a bond
NH
S
NH
Q3a
OH


938
N
O
Q1x
a bond
Me
a bond
NH
S
NH
Q3b
OH


939
N
O
Q1x
a bond
Me
a bond
NH
S
NH
Q3c
OH


940
N
O
Q1x
a bond
Me
a bond
NH
S
a bond
Q3a
OH


941
N
O
Q1x
a bond
Me
a bond
NH
S
a bond
Q3b
OH


942
N
O
Q1x
a bond
Me
a bond
NH
S
a bond
Q3c
OH


943
N
O
Q1x
a bond
Me
a bond
NH
O
NH
Q3a
OH


944
N
O
Q1x
a bond
Me
a bond
NH
O
NH
Q3b
OH


945
N
O
Q1x
a bond
Me
a bond
NH
O
NH
Q3c
OH


946
N
O
Q1x
a bond
Me
a bond
NH
O
a bond
Q3a
OH


947
N
O
Q1x
a bond
Me
a bond
NH
O
a bond
Q3b
OH


948
N
O
Q1x
a bond
Me
a bond
NH
O
a bond
Q3c
OH


949
N
O
Q1x
a bond
H
a bond
NH
S
NH
Q3a
OH


950
N
O
Q1x
a bond
H
a bond
NH
S
NH
Q3b
OH


951
N
O
Q1x
a bond
H
a bond
NH
S
NH
Q3c
OH


952
N
O
Q1x
a bond
H
a bond
NH
S
a bond
Q3a
OH


953
N
O
Q1x
a bond
H
a bond
NH
S
a bond
Q3b
OH


954
N
O
Q1x
a bond
H
a bond
NH
S
a bond
Q3c
OH


955
N
O
Q1x
a bond
H
a bond
NH
O
NH
Q3a
OH


956
N
O
Q1x
a bond
H
a bond
NH
O
NH
Q3b
OH


957
N
O
Q1x
a bond
H
a bond
NH
O
NH
Q3c
OH


958
N
O
Q1x
a bond
H
a bond
NH
O
a bond
Q3a
OH


959
N
O
Q1x
a bond
H
a bond
NH
O
a bond
Q3b
OH


960
N
O
Q1x
a bond
H
a bond
NH
O
a bond
Q3c
OH


961
CH
NMe
Q1o
a bond
Me
a bond
NH
S
NH
Q3a
OH


962
CH
NMe
Q1o
a bond
Me
a bond
NH
S
NH
Q3b
OH


963
CH
NMe
Q1o
a bond
Me
a bond
NH
S
NH
Q3c
OH


964
CH
NMe
Q1o
a bond
Me
a bond
NH
S
a bond
Q3a
OH


965
CH
NMe
Q1o
a bond
Me
a bond
NH
S
a bond
Q3b
OH


966
CH
NMe
Q1o
a bond
Me
a bond
NH
S
a bond
Q3c
OH


967
CH
NMe
Q1o
a bond
Me
a bond
NH
O
NH
Q3a
OH


968
CH
NMe
Q1o
a bond
Me
a bond
NH
O
NH
Q3b
OH


969
CH
NMe
Q1o
a bond
Me
a bond
NH
O
NH
Q3c
OH


970
CH
NMe
Q1o
a bond
Me
a bond
NH
O
a bond
Q3a
OH


971
CH
NMe
Q1o
a bond
Me
a bond
NH
O
a bond
Q3b
OH


972
CH
NMe
Q1o
a bond
Me
a bond
NH
O
a bond
Q3c
OH


973
CH
NMe
Q1o
a bond
H
a bond
NH
S
NH
Q3a
OH


974
CH
NMe
Q1o
a bond
H
a bond
NH
S
NH
Q3b
OH


975
CH
NMe
Q1o
a bond
H
a bond
NH
S
NH
Q3c
OH


976
CH
NMe
Q1o
a bond
H
a bond
NH
S
a bond
Q3a
OH


977
CH
NMe
Q1o
a bond
H
a bond
NH
S
a bond
Q3b
OH


978
CH
NMe
Q1o
a bond
H
a bond
NH
S
a bond
Q3c
OH


979
CH
NMe
Q1o
a bond
H
a bond
NH
O
NH
Q3a
OH


980
CH
NMe
Q1o
a bond
H
a bond
NH
O
NH
Q3b
OH


981
CH
NMe
Q1o
a bond
H
a bond
NH
O
NH
Q3c
OH


982
CH
NMe
Q1o
a bond
H
a bond
NH
O
a bond
Q3a
OH


983
CH
NMe
Q1o
a bond
H
a bond
NH
O
a bond
Q3b
OH


984
CH
NMe
Q1o
a bond
H
a bond
NH
O
a bond
Q3c
OH


985
CH
NMe
Q1p
a bond
Me
a bond
NH
S
NH
Q3a
OH


986
CH
NMe
Q1p
a bond
Me
a bond
NH
S
NH
Q3b
OH


987
CH
NMe
Q1p
a bond
Me
a bond
NH
S
NH
Q3c
OH


988
CH
NMe
Q1p
a bond
Me
a bond
NH
S
a bond
Q3a
OH


989
CH
NMe
Q1p
a bond
Me
a bond
NH
S
a bond
Q3b
OH


990
CH
NMe
Q1p
a bond
Me
a bond
NH
S
a bond
Q3c
OH


991
CH
NMe
Q1p
a bond
Me
a bond
NH
O
NH
Q3a
OH


992
CH
NMe
Q1p
a bond
Me
a bond
NH
O
NH
Q3b
OH


993
CH
NMe
Q1p
a bond
Me
a bond
NH
O
NH
Q3c
OH


994
CH
NMe
Q1p
a bond
Me
a bond
NH
O
a bond
Q3a
OH


995
CH
NMe
Q1p
a bond
Me
a bond
NH
O
a bond
Q3b
OH


996
CH
NMe
Q1p
a bond
Me
a bond
NH
O
a bond
Q3c
OH


997
CH
NMe
Q1p
a bond
H
a bond
NH
S
NH
Q3a
OH


998
CH
NMe
Q1p
a bond
H
a bond
NH
S
NH
Q3b
OH


999
CH
NMe
Q1p
a bond
H
a bond
NH
S
NH
Q3c
OH


1000
CH
NMe
Q1p
a bond
H
a bond
NH
S
a bond
Q3a
OH


1001
CH
NMe
Q1p
a bond
H
a bond
NH
S
a bond
Q3b
OH


1002
CH
NMe
Q1p
a bond
H
a bond
NH
S
a bond
Q3c
OH


1003
CH
NMe
Q1p
a bond
H
a bond
NH
O
NH
Q3a
OH


1004
CH
NMe
Q1p
a bond
H
a bond
NH
O
NH
Q3b
OH


1005
CH
NMe
Q1p
a bond
H
a bond
NH
O
NH
Q3c
OH


1006
CH
NMe
Q1p
a bond
H
a bond
NH
O
a bond
Q3a
OH


1007
CH
NMe
Q1p
a bond
H
a bond
NH
O
a bond
Q3b
OH


1008
CH
NMe
Q1p
a bond
H
a bond
NH
O
a bond
Q3c
OH


1009
CH
NMe
Q1q
a bond
Me
a bond
NH
S
NH
Q3a
OH


1010
CH
NMe
Q1q
a bond
Me
a bond
NH
S
NH
Q3b
OH


1011
CH
NMe
Q1q
a bond
Me
a bond
NH
S
NH
Q3c
OH


1012
CH
NMe
Q1q
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1013
CH
NMe
Q1q
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1014
CH
NMe
Q1q
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1015
CH
NMe
Q1q
a bond
Me
a bond
NH
O
NH
Q3a
OH


1016
CH
NMe
Q1q
a bond
Me
a bond
NH
O
NH
Q3b
OH


1017
CH
NMe
Q1q
a bond
Me
a bond
NH
O
NH
Q3c
OH


1018
CH
NMe
Q1q
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1019
CH
NMe
Q1q
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1020
CH
NMe
Q1q
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1021
CH
NMe
Q1q
a bond
H
a bond
NH
S
NH
Q3a
OH


1022
CH
NMe
Q1q
a bond
H
a bond
NH
S
NH
Q3b
OH


1023
CH
NMe
Q1q
a bond
H
a bond
NH
S
NH
Q3c
OH


1024
CH
NMe
Q1q
a bond
H
a bond
NH
S
a bond
Q3a
OH


1025
CH
NMe
Q1q
a bond
H
a bond
NH
S
a bond
Q3b
OH


1026
CH
NMe
Q1q
a bond
H
a bond
NH
S
a bond
Q3c
OH


1027
CH
NMe
Q1q
a bond
H
a bond
NH
O
NH
Q3a
OH


1028
CH
NMe
Q1q
a bond
H
a bond
NH
O
NH
Q3b
OH


1029
CH
NMe
Q1q
a bond
H
a bond
NH
O
NH
Q3c
OH


1030
CH
NMe
Q1q
a bond
H
a bond
NH
O
a bond
Q3a
OH


1031
CH
NMe
Q1q
a bond
H
a bond
NH
O
a bond
Q3b
OH


1032
CH
NMe
Q1p
a bond
H
a bond
NH
O
a bond
Q3c
OH


1033
CH
NMe
Q1r
a bond
Me
a bond
NH
S
NH
Q3a
OH


1034
CH
NMe
Q1r
a bond
Me
a bond
NH
S
NH
Q3b
OH


1035
CH
NMe
Q1r
a bond
Me
a bond
NH
S
NH
Q3c
OH


1036
CH
NMe
Q1r
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1037
CH
NMe
Q1r
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1038
CH
NMe
Q1r
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1039
CH
NMe
Q1r
a bond
Me
a bond
NH
O
NH
Q3a
OH


1040
CH
NMe
Q1r
a bond
Me
a bond
NH
O
NH
Q3b
OH


1041
CH
NMe
Q1r
a bond
Me
a bond
NH
O
NH
Q3c
OH


1042
CH
NMe
Q1r
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1043
CH
NMe
Q1r
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1044
CH
NMe
Q1r
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1045
CH
NMe
Q1r
a bond
H
a bond
NH
S
NH
Q3a
OH


1046
CH
NMe
Q1r
a bond
H
a bond
NH
S
NH
Q3b
OH


1047
CH
NMe
Q1r
a bond
H
a bond
NH
S
NH
Q3c
OH


1048
CH
NMe
Q1r
a bond
H
a bond
NH
S
a bond
Q3a
OH


1049
CH
NMe
Q1r
a bond
H
a bond
NH
S
a bond
Q3b
OH


1050
CH
NMe
Q1r
a bond
H
a bond
NH
S
a bond
Q3c
OH


1051
CH
NMe
Q1r
a bond
H
a bond
NH
O
NH
Q3a
OH


1052
CH
NMe
Q1r
a bond
H
a bond
NH
O
NH
Q3b
OH


1053
CH
NMe
Q1r
a bond
H
a bond
NH
O
NH
Q3c
OH


1054
CH
NMe
Q1r
a bond
H
a bond
NH
O
a bond
Q3a
OH


1055
CH
NMe
Q1r
a bond
H
a bond
NH
O
a bond
Q3b
OH


1056
CH
NMe
Q1r
a bond
H
a bond
NH
O
a bond
Q3c
OH


1057
CH
NMe
Q1s
a bond
Me
a bond
NH
S
NH
Q3a
OH


1058
CH
NMe
Q1s
a bond
Me
a bond
NH
S
NH
Q3b
OH


1059
CH
NMe
Q1s
a bond
Me
a bond
NH
S
NH
Q3c
OH


1060
CH
NMe
Q1s
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1061
CH
NMe
Q1s
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1062
CH
NMe
Q1s
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1063
CH
NMe
Q1s
a bond
Me
a bond
NH
O
NH
Q3a
OH


1064
CH
NMe
Q1s
a bond
Me
a bond
NH
O
NH
Q3b
OH


1065
CH
NMe
Q1s
a bond
Me
a bond
NH
O
NH
Q3c
OH


1066
CH
NMe
Q1s
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1067
CH
NMe
Q1s
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1068
CH
NMe
Q1s
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1069
CH
NMe
Q1s
a bond
H
a bond
NH
S
NH
Q3a
OH


1070
CH
NMe
Q1s
a bond
H
a bond
NH
S
NH
Q3b
OH


1071
CH
NMe
Q1s
a bond
H
a bond
NH
S
NH
Q3c
OH


1072
CH
NMe
Q1s
a bond
H
a bond
NH
S
a bond
Q3a
OH


1073
CH
NMe
Q1s
a bond
H
a bond
NH
S
a bond
Q3b
OH


1074
CH
NMe
Q1s
a bond
H
a bond
NH
S
a bond
Q3c
OH


1075
CH
NMe
Q1s
a bond
H
a bond
NH
O
NH
Q3a
OH


1076
CH
NMe
Q1s
a bond
H
a bond
NH
O
NH
Q3b
OH


1077
CH
NMe
Q1s
a bond
H
a bond
NH
O
NH
Q3c
OH


1078
CH
NMe
Q1s
a bond
H
a bond
NH
O
a bond
Q3a
OH


1079
CH
NMe
Q1s
a bond
H
a bond
NH
O
a bond
Q3b
OH


1080
CH
NMe
Q1s
a bond
H
a bond
NH
O
a bond
Q3c
OH


1081
CH
NMe
Q1t
a bond
Me
a bond
NH
S
NH
Q3a
OH


1082
CH
NMe
Q1t
a bond
Me
a bond
NH
S
NH
Q3b
OH


1083
CH
NMe
Q1t
a bond
Me
a bond
NH
S
NH
Q3c
OH


1084
CH
NMe
Q1t
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1085
CH
NMe
Q1t
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1086
CH
NMe
Q1t
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1087
CH
NMe
Q1t
a bond
Me
a bond
NH
O
NH
Q3a
OH


1088
CH
NMe
Q1t
a bond
Me
a bond
NH
O
NH
Q3b
OH


1089
CH
NMe
Q1t
a bond
Me
a bond
NH
O
NH
Q3c
OH


1090
CH
NMe
Q1t
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1091
CH
NMe
Q1t
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1092
CH
NMe
Q1t
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1093
CH
NMe
Q1t
a bond
H
a bond
NH
S
NH
Q3a
OH


1094
CH
NMe
Q1t
a bond
H
a bond
NH
S
NH
Q3b
OH


1095
CH
NMe
Q1t
a bond
H
a bond
NH
S
NH
Q3c
OH


1096
CH
NMe
Q1t
a bond
H
a bond
NH
S
a bond
Q3a
OH


1097
CH
NMe
Q1t
a bond
H
a bond
NH
S
a bond
Q3b
OH


1098
CH
NMe
Q1t
a bond
H
a bond
NH
S
a bond
Q3c
OH


1099
CH
NMe
Q1t
a bond
H
a bond
NH
O
NH
Q3a
OH


1100
CH
NMe
Q1t
a bond
H
a bond
NH
O
NH
Q3b
OH


1101
CH
NMe
Q1t
a bond
H
a bond
NH
O
NH
Q3c
OH


1102
CH
NMe
Q1t
a bond
H
a bond
NH
O
a bond
Q3a
OH


1103
CH
NMe
Q1t
a bond
H
a bond
NH
O
a bond
Q3b
OH


1104
CH
NMe
Q1t
a bond
H
a bond
NH
O
a bond
Q3c
OH


1105
CH
NMe
Q1u
a bond
Me
a bond
NH
S
NH
Q3a
OH


1106
CH
NMe
Q1u
a bond
Me
a bond
NH
S
NH
Q3b
OH


1107
CH
NMe
Q1u
a bond
Me
a bond
NH
S
NH
Q3c
OH


1108
CH
NMe
Q1u
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1109
CH
NMe
Q1u
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1110
CH
NMe
Q1u
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1111
CH
NMe
Q1u
a bond
Me
a bond
NH
O
NH
Q3a
OH


1112
CH
NMe
Q1u
a bond
Me
a bond
NH
O
NH
Q3b
OH


1113
CH
NMe
Q1u
a bond
Me
a bond
NH
O
NH
Q3c
OH


1114
CH
NMe
Q1u
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1115
CH
NMe
Q1u
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1116
CH
NMe
Q1u
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1117
CH
NMe
Q1u
a bond
H
a bond
NH
S
NH
Q3a
OH


1118
CH
NMe
Q1u
a bond
H
a bond
NH
S
NH
Q3b
OH


1119
CH
NMe
Q1u
a bond
H
a bond
NH
S
NH
Q3c
OH


1120
CH
NMe
Q1u
a bond
H
a bond
NH
S
a bond
Q3a
OH


1121
CH
NMe
Q1u
a bond
H
a bond
NH
S
a bond
Q3b
OH


1122
CH
NMe
Q1u
a bond
H
a bond
NH
S
a bond
Q3c
OH


1123
CH
NMe
Q1u
a bond
H
a bond
NH
O
NH
Q3a
OH


1124
CH
NMe
Q1u
a bond
H
a bond
NH
O
NH
Q3b
OH


1125
CH
NMe
Q1u
a bond
H
a bond
NH
O
NH
Q3c
OH


1126
CH
NMe
Q1u
a bond
H
a bond
NH
O
a bond
Q3a
OH


1127
CH
NMe
Q1u
a bond
H
a bond
NH
O
a bond
Q3b
OH


1128
CH
NMe
Q1u
a bond
H
a bond
NH
O
a bond
Q3c
OH


1129
CH
NMe
Q1v
a bond
Me
a bond
NH
S
NH
Q3a
OH


1130
CH
NMe
Q1v
a bond
Me
a bond
NH
S
NH
Q3b
OH


1131
CH
NMe
Q1v
a bond
Me
a bond
NH
S
NH
Q3c
OH


1132
CH
NMe
Q1v
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1133
CH
NMe
Q1v
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1134
CH
NMe
Q1v
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1135
CH
NMe
Q1v
a bond
Me
a bond
NH
O
NH
Q3a
OH


1136
CH
NMe
Q1v
a bond
Me
a bond
NH
O
NH
Q3b
OH


1137
CH
NMe
Q1v
a bond
Me
a bond
NH
O
NH
Q3c
OH


1138
CH
NMe
Q1v
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1139
CH
NMe
Q1v
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1140
CH
NMe
Q1v
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1141
CH
NMe
Q1v
a bond
H
a bond
NH
S
NH
Q3a
OH


1142
CH
NMe
Q1v
a bond
H
a bond
NH
S
NH
Q3b
OH


1143
CH
NMe
Q1v
a bond
H
a bond
NH
S
NH
Q3c
OH


1144
CH
NMe
Q1v
a bond
H
a bond
NH
S
a bond
Q3a
OH


1145
CH
NMe
Q1v
a bond
H
a bond
NH
S
a bond
Q3b
OH


1146
CH
NMe
Q1v
a bond
H
a bond
NH
S
a bond
Q3c
OH


1147
CH
NMe
Q1v
a bond
H
a bond
NH
O
NH
Q3a
OH


1148
CH
NMe
Q1v
a bond
H
a bond
NH
O
NH
Q3b
OH


1149
CH
NMe
Q1v
a bond
H
a bond
NH
O
NH
Q3c
OH


1150
CH
NMe
Q1v
a bond
H
a bond
NH
O
a bond
Q3a
OH


1151
CH
NMe
Q1v
a bond
H
a bond
NH
O
a bond
Q3b
OH


1152
CH
NMe
Q1v
a bond
H
a bond
NH
O
a bond
Q3c
OH


1153
CH
NMe
Q1w
a bond
Me
a bond
NH
S
NH
Q3a
OH


1154
CH
NMe
Q1w
a bond
Me
a bond
NH
S
NH
Q3b
OH


1155
CH
NMe
Q1w
a bond
Me
a bond
NH
S
NH
Q3c
OH


1156
CH
NMe
Q1w
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1157
CH
NMe
Q1w
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1158
CH
NMe
Q1w
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1159
CH
NMe
Q1w
a bond
Me
a bond
NH
O
NH
Q3a
OH


1160
CH
NMe
Q1w
a bond
Me
a bond
NH
O
NH
Q3b
OH


1161
CH
NMe
Q1w
a bond
Me
a bond
NH
O
NH
Q3c
OH


1162
CH
NMe
Q1w
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1163
CH
NMe
Q1w
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1164
CH
NMe
Q1w
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1165
CH
NMe
Q1w
a bond
H
a bond
NH
S
NH
Q3a
OH


1166
CH
NMe
Q1w
a bond
H
a bond
NH
S
NH
Q3b
OH


1167
CH
NMe
Q1w
a bond
H
a bond
NH
S
NH
Q3c
OH


1168
CH
NMe
Q1w
a bond
H
a bond
NH
S
a bond
Q3a
OH


1169
CH
NMe
Q1w
a bond
H
a bond
NH
S
a bond
Q3b
OH


1170
CH
NMe
Q1w
a bond
H
a bond
NH
S
a bond
Q3c
OH


1171
CH
NMe
Q1w
a bond
H
a bond
NH
O
NH
Q3a
OH


1172
CH
NMe
Q1w
a bond
H
a bond
NH
O
NH
Q3b
OH


1173
CH
NMe
Q1w
a bond
H
a bond
NH
O
NH
Q3c
OH


1174
CH
NMe
Q1w
a bond
H
a bond
NH
O
a bond
Q3a
OH


1175
CH
NMe
Q1w
a bond
H
a bond
NH
O
a bond
Q3b
OH


1176
CH
NMe
Q1w
a bond
H
a bond
NH
O
a bond
Q3c
OH


1177
CH
NMe
Q1x
a bond
Me
a bond
NH
S
NH
Q3a
OH


1178
CH
NMe
Q1x
a bond
Me
a bond
NH
S
NH
Q3b
OH


1179
CH
NMe
Q1x
a bond
Me
a bond
NH
S
NH
Q3c
OH


1180
CH
NMe
Q1x
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1181
CH
NMe
Q1x
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1182
CH
NMe
Q1x
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1183
CH
NMe
Q1x
a bond
Me
a bond
NH
O
NH
Q3a
OH


1184
CH
NMe
Q1x
a bond
Me
a bond
NH
O
NH
Q3b
OH


1185
CH
NMe
Q1x
a bond
Me
a bond
NH
O
NH
Q3c
OH


1186
CH
NMe
Q1x
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1187
CH
NMe
Q1x
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1188
CH
NMe
Q1x
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1189
CH
NMe
Q1x
a bond
H
a bond
NH
S
NH
Q3a
OH


1190
CH
NMe
Q1x
a bond
H
a bond
NH
S
NH
Q3b
OH


1191
CH
NMe
Q1x
a bond
H
a bond
NH
S
NH
Q3c
OH


1192
CH
NMe
Q1x
a bond
H
a bond
NH
S
a bond
Q3a
OH


1193
CH
NMe
Q1x
a bond
H
a bond
NH
S
a bond
Q3b
OH


1194
CH
NMe
Q1x
a bond
H
a bond
NH
S
a bond
Q3c
OH


1195
CH
NMe
Q1x
a bond
H
a bond
NH
O
NH
Q3a
OH


1196
CH
NMe
Q1x
a bond
H
a bond
NH
O
NH
Q3b
OH


1197
CH
NMe
Q1x
a bond
H
a bond
NH
O
NH
Q3c
OH


1198
CH
NMe
Q1x
a bond
H
a bond
NH
O
a bond
Q3a
OH


1199
CH
NMe
Q1x
a bond
H
a bond
NH
O
a bond
Q3b
OH


1200
CH
NMe
Q1x
a bond
H
a bond
NH
O
a bond
Q3c
OH


1201
CH
NEt
Q1o
a bond
Me
a bond
NH
S
NH
Q3a
OH


1202
CH
NEt
Q1o
a bond
Me
a bond
NH
S
NH
Q3b
OH


1203
CH
NEt
Q1o
a bond
Me
a bond
NH
S
NH
Q3c
OH


1204
CH
NEt
Q1o
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1205
CH
NEt
Q1o
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1206
CH
NEt
Q1o
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1207
CH
NEt
Q1o
a bond
Me
a bond
NH
O
NH
Q3a
OH


1208
CH
NEt
Q1o
a bond
Me
a bond
NH
O
NH
Q3b
OH


1209
CH
NEt
Q1o
a bond
Me
a bond
NH
O
NH
Q3c
OH


1210
CH
NEt
Q1o
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1211
CH
NEt
Q1o
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1212
CH
NEt
Q1o
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1213
CH
NEt
Q1o
a bond
H
a bond
NH
S
NH
Q3a
OH


1214
CH
NEt
Q1o
a bond
H
a bond
NH
S
NH
Q3b
OH


1215
CH
NEt
Q1o
a bond
H
a bond
NH
S
NH
Q3c
OH


1216
CH
NEt
Q1o
a bond
H
a bond
NH
S
a bond
Q3a
OH


1217
CH
NEt
Q1o
a bond
H
a bond
NH
S
a bond
Q3b
OH


1218
CH
NEt
Q1o
a bond
H
a bond
NH
S
a bond
Q3c
OH


1219
CH
NEt
Q1o
a bond
H
a bond
NH
O
NH
Q3a
OH


1220
CH
NEt
Q1o
a bond
H
a bond
NH
O
NH
Q3b
OH


1221
CH
NEt
Q1o
a bond
H
a bond
NH
O
NH
Q3c
OH


1222
CH
NEt
Q1o
a bond
H
a bond
NH
O
a bond
Q3a
OH


1223
CH
NEt
Q1o
a bond
H
a bond
NH
O
a bond
Q3b
OH


1224
CH
NEt
Q1o
a bond
H
a bond
NH
O
a bond
Q3c
OH


1225
CH
NEt
Q1p
a bond
Me
a bond
NH
S
NH
Q3a
OH


1226
CH
NEt
Q1p
a bond
Me
a bond
NH
S
NH
Q3b
OH


1227
CH
NEt
Q1p
a bond
Me
a bond
NH
S
NH
Q3c
OH


1228
CH
NEt
Q1p
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1229
CH
NEt
Q1p
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1230
CH
NEt
Q1p
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1231
CH
NEt
Q1p
a bond
Me
a bond
NH
O
NH
Q3a
OH


1232
CH
NEt
Q1p
a bond
Me
a bond
NH
O
NH
Q3b
OH


1233
CH
NEt
Q1p
a bond
Me
a bond
NH
O
NH
Q3c
OH


1234
CH
NEt
Q1p
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1235
CH
NEt
Q1p
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1236
CH
NEt
Q1p
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1237
CH
NEt
Q1p
a bond
H
a bond
NH
S
NH
Q3a
OH


1238
CH
NEt
Q1p
a bond
H
a bond
NH
S
NH
Q3b
OH


1239
CH
NEt
Q1p
a bond
H
a bond
NH
S
NH
Q3c
OH


1240
CH
NEt
Q1p
a bond
H
a bond
NH
S
a bond
Q3a
OH


1241
CH
NEt
Q1p
a bond
H
a bond
NH
S
a bond
Q3b
OH


1242
CH
NEt
Q1p
a bond
H
a bond
NH
S
a bond
Q3c
OH


1243
CH
NEt
Q1p
a bond
H
a bond
NH
O
NH
Q3a
OH


1244
CH
NEt
Q1p
a bond
H
a bond
NH
O
NH
Q3b
OH


1245
CH
NEt
Q1p
a bond
H
a bond
NH
O
NH
Q3c
OH


1246
CH
NEt
Q1p
a bond
H
a bond
NH
O
a bond
Q3a
OH


1247
CH
NEt
Q1p
a bond
H
a bond
NH
O
a bond
Q3b
OH


1248
CH
NEt
Q1p
a bond
H
a bond
NH
O
a bond
Q3c
OH


1249
CH
NEt
Q1q
a bond
Me
a bond
NH
S
NH
Q3a
OH


1250
CH
NEt
Q1q
a bond
Me
a bond
NH
S
NH
Q3b
OH


1251
CH
NEt
Q1q
a bond
Me
a bond
NH
S
NH
Q3c
OH


1252
CH
NEt
Q1q
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1253
CH
NEt
Q1q
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1254
CH
NEt
Q1q
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1255
CH
NEt
Q1q
a bond
Me
a bond
NH
O
NH
Q3a
OH


1256
CH
NEt
Q1q
a bond
Me
a bond
NH
O
NH
Q3b
OH


1257
CH
NEt
Q1q
a bond
Me
a bond
NH
O
NH
Q3c
OH


1258
CH
NEt
Q1q
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1259
CH
NEt
Q1q
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1260
CH
NEt
Q1q
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1261
CH
NEt
Q1q
a bond
H
a bond
NH
S
NH
Q3a
OH


1262
CH
NEt
Q1q
a bond
H
a bond
NH
S
NH
Q3b
OH


1263
CH
NEt
Q1q
a bond
H
a bond
NH
S
NH
Q3c
OH


1264
CH
NEt
Q1q
a bond
H
a bond
NH
S
a bond
Q3a
OH


1265
CH
NEt
Q1q
a bond
H
a bond
NH
S
a bond
Q3b
OH


1266
CH
NEt
Q1q
a bond
H
a bond
NH
S
a bond
Q3c
OH


1267
CH
NEt
Q1q
a bond
H
a bond
NH
O
NH
Q3a
OH


1268
CH
NEt
Q1q
a bond
H
a bond
NH
O
NH
Q3b
OH


1269
CH
NEt
Q1q
a bond
H
a bond
NH
O
NH
Q3c
OH


1270
CH
NEt
Q1q
a bond
H
a bond
NH
O
a bond
Q3a
OH


1271
CH
NEt
Q1q
a bond
H
a bond
NH
O
a bond
Q3b
OH


1272
CH
NEt
Q1q
a bond
H
a bond
NH
O
a bond
Q3c
OH


1273
CH
NEt
Q1r
a bond
Me
a bond
NH
S
NH
Q3a
OH


1274
CH
NEt
Q1r
a bond
Me
a bond
NH
S
NH
Q3b
OH


1275
CH
NEt
Q1r
a bond
Me
a bond
NH
S
NH
Q3c
OH


1276
CH
NEt
Q1r
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1277
CH
NEt
Q1r
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1278
CH
NEt
Q1r
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1279
CH
NEt
Q1r
a bond
Me
a bond
NH
O
NH
Q3a
OH


1280
CH
NEt
Q1r
a bond
Me
a bond
NH
O
NH
Q3b
OH


1281
CH
NEt
Q1r
a bond
Me
a bond
NH
O
NH
Q3c
OH


1282
CH
NEt
Q1r
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1283
CH
NEt
Q1r
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1284
CH
NEt
Q1r
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1285
CH
NEt
Q1r
a bond
H
a bond
NH
S
NH
Q3a
OH


1286
CH
NEt
Q1r
a bond
H
a bond
NH
S
NH
Q3b
OH


1287
CH
NEt
Q1r
a bond
H
a bond
NH
S
NH
Q3c
OH


1288
CH
NEt
Q1r
a bond
H
a bond
NH
S
a bond
Q3a
OH


1289
CH
NEt
Q1r
a bond
H
a bond
NH
S
a bond
Q3b
OH


1290
CH
NEt
Q1r
a bond
H
a bond
NH
S
a bond
Q3c
OH


1291
CH
NEt
Q1r
a bond
H
a bond
NH
O
NH
Q3a
OH


1292
CH
NEt
Q1r
a bond
H
a bond
NH
O
NH
Q3b
OH


1293
CH
NEt
Q1r
a bond
H
a bond
NH
O
NH
Q3c
OH


1294
CH
NEt
Q1r
a bond
H
a bond
NH
O
a bond
Q3a
OH


1295
CH
NEt
Q1r
a bond
H
a bond
NH
O
a bond
Q3b
OH


1296
CH
NEt
Q1r
a bond
H
a bond
NH
O
a bond
Q3c
OH


1297
CH
NEt
Q1s
a bond
Me
a bond
NH
S
NH
Q3a
OH


1298
CH
NEt
Q1s
a bond
Me
a bond
NH
S
NH
Q3b
OH


1299
CH
NEt
Q1s
a bond
Me
a bond
NH
S
NH
Q3c
OH


1300
CH
NEt
Q1s
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1301
CH
NEt
Q1s
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1302
CH
NEt
Q1s
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1303
CH
NEt
Q1s
a bond
Me
a bond
NH
O
NH
Q3a
OH


1304
CH
NEt
Q1s
a bond
Me
a bond
NH
O
NH
Q3b
OH


1305
CH
NEt
Q1s
a bond
Me
a bond
NH
O
NH
Q3c
OH


1306
CH
NEt
Q1s
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1307
CH
NEt
Q1s
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1308
CH
NEt
Q1s
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1309
CH
NEt
Q1s
a bond
H
a bond
NH
S
NH
Q3a
OH


1310
CH
NEt
Q1s
a bond
H
a bond
NH
S
NH
Q3b
OH


1311
CH
NEt
Q1s
a bond
H
a bond
NH
S
NH
Q3c
OH


1312
CH
NEt
Q1s
a bond
H
a bond
NH
S
a bond
Q3a
OH


1313
CH
NEt
Q1s
a bond
H
a bond
NH
S
a bond
Q3b
OH


1314
CH
NEt
Q1s
a bond
H
a bond
NH
S
a bond
Q3c
OH


1315
CH
NEt
Q1s
a bond
H
a bond
NH
O
NH
Q3a
OH


1316
CH
NEt
Q1s
a bond
H
a bond
NH
O
NH
Q3b
OH


1317
CH
NEt
Q1s
a bond
H
a bond
NH
O
NH
Q3c
OH


1318
CH
NEt
Q1s
a bond
H
a bond
NH
O
a bond
Q3a
OH


1319
CH
NEt
Q1s
a bond
H
a bond
NH
O
a bond
Q3b
OH


1320
CH
NEt
Q1s
a bond
H
a bond
NH
O
a bond
Q3c
OH


1321
CH
NEt
Q1t
a bond
Me
a bond
NH
S
NH
Q3a
OH


1322
CH
NEt
Q1t
a bond
Me
a bond
NH
S
NH
Q3b
OH


1323
CH
NEt
Q1t
a bond
Me
a bond
NH
S
NH
Q3c
OH


1324
CH
NEt
Q1t
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1325
CH
NEt
Q1t
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1326
CH
NEt
Q1t
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1327
CH
NEt
Q1t
a bond
Me
a bond
NH
O
NH
Q3a
OH


1328
CH
NEt
Q1t
a bond
Me
a bond
NH
O
NH
Q3b
OH


1329
CH
NEt
Q1t
a bond
Me
a bond
NH
O
NH
Q3c
OH


1330
CH
NEt
Q1t
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1331
CH
NEt
Q1t
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1332
CH
NEt
Q1t
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1333
CH
NEt
Q1t
a bond
H
a bond
NH
S
NH
Q3a
OH


1334
CH
NEt
Q1t
a bond
H
a bond
NH
S
NH
Q3b
OH


1335
CH
NEt
Q1t
a bond
H
a bond
NH
S
NH
Q3c
OH


1336
CH
NEt
Q1t
a bond
H
a bond
NH
S
a bond
Q3a
OH


1337
CH
NEt
Q1t
a bond
H
a bond
NH
S
a bond
Q3b
OH


1338
CH
NEt
Q1t
a bond
H
a bond
NH
S
a bond
Q3c
OH


1339
CH
NEt
Q1t
a bond
H
a bond
NH
O
NH
Q3a
OH


1340
CH
NEt
Q1t
a bond
H
a bond
NH
O
NH
Q3b
OH


1341
CH
NEt
Q1t
a bond
H
a bond
NH
O
NH
Q3c
OH


1342
CH
NEt
Q1t
a bond
H
a bond
NH
O
a bond
Q3a
OH


1343
CH
NEt
Q1t
a bond
H
a bond
NH
O
a bond
Q3b
OH


i344
CH
NEt
Q1t
a bond
H
a bond
NH
O
a bond
Q3c
OH


1345
CH
NEt
Q1u
a bond
Me
a bond
NH
S
NH
Q3a
OH


1346
CH
NEt
Q1u
a bond
Me
a bond
NH
S
NH
Q3b
OH


1347
CH
NEt
Q1u
a bond
Me
a bond
NH
S
NH
Q3c
OH


1348
CH
NEt
Q1u
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1349
CH
NEt
Q1u
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1350
CH
NEt
Q1u
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1351
CH
NEt
Q1u
a bond
Me
a bond
NH
O
NH
Q3a
OH


1352
CH
NEt
Q1u
a bond
Me
a bond
NH
O
NH
Q3b
OH


1353
CH
NEt
Q1u
a bond
Me
a bond
NH
O
NH
Q3c
OH


1354
CH
NEt
Q1u
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1355
CH
NEt
Q1u
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1356
CH
NEt
Q1u
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1357
CH
NEt
Q1u
a bond
H
a bond
NH
S
NH
Q3a
OH


1358
CH
NEt
Q1u
a bond
H
a bond
NH
S
NH
Q3b
OH


1359
CH
NEt
Q1u
a bond
H
a bond
NH
S
NH
Q3c
OH


1360
CH
NEt
Q1u
a bond
H
a bond
NH
S
a bond
Q3a
OH


1361
CH
NEt
Q1u
a bond
H
a bond
NH
S
a bond
Q3b
OH


1362
CH
NEt
Q1u
a bond
H
a bond
NH
S
a bond
Q3c
OH


1363
CH
NEt
Q1u
a bond
H
a bond
NH
O
NH
Q3a
OH


1364
CH
NEt
Q1u
a bond
H
a bond
NH
O
NH
Q3b
OH


1365
CH
NEt
Q1u
a bond
H
a bond
NH
O
NH
Q3c
OH


1366
CH
NEt
Q1u
a bond
H
a bond
NH
O
a bond
Q3a
OH


1367
CH
NEt
Q1u
a bond
H
a bond
NH
O
a bond
Q3b
OH


1368
CH
NEt
Q1u
a bond
H
a bond
NH
O
a bond
Q3c
OH


1369
CH
NEt
Q1v
a bond
Me
a bond
NH
S
NH
Q3a
OH


1370
CH
NEt
Q1v
a bond
Me
a bond
NH
S
NH
Q3b
OH


1371
CH
NEt
Q1v
a bond
Me
a bond
NH
S
NH
Q3c
OH


1372
CH
NEt
Q1v
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1373
CH
NEt
Q1v
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1374
CH
NEt
Q1v
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1375
CH
NEt
Q1v
a bond
Me
a bond
NH
O
NH
Q3a
OH


1376
CH
NEt
Q1v
a bond
Me
a bond
NH
O
NH
Q3b
OH


1377
CH
NEt
Q1v
a bond
Me
a bond
NH
O
NH
Q3c
OH


1378
CH
NEt
Q1v
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1379
CH
NEt
Q1v
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1380
CH
NEt
Q1v
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1381
CH
NEt
Q1v
a bond
H
a bond
NH
S
NH
Q3a
OH


1382
CH
NEt
Q1v
a bond
H
a bond
NH
S
NH
Q3b
OH


1383
CH
NEt
Q1v
a bond
H
a bond
NH
S
NH
Q3c
OH


1384
CH
NEt
Q1v
a bond
H
a bond
NH
S
a bond
Q3a
OH


1385
CH
NEt
Q1v
a bond
H
a bond
NH
S
a bond
Q3b
OH


1386
CH
NEt
Q1v
a bond
H
a bond
NH
S
a bond
Q3c
OH


1387
CH
NEt
Q1v
a bond
H
a bond
NH
O
NH
Q3a
OH


1388
CH
NEt
Q1v
a bond
H
a bond
NH
O
NH
Q3b
OH


1389
CH
NEt
Q1v
a bond
H
a bond
NH
O
NH
Q3c
OH


1390
CH
NEt
Q1v
a bond
H
a bond
NH
O
a bond
Q3a
OH


1391
CH
NEt
Q1v
a bond
H
a bond
NH
O
a bond
Q3b
OH


1392
CH
NEt
Q1v
a bond
H
a bond
NH
O
a bond
Q3c
OH


1393
CH
NEt
Q1w
a bond
Me
a bond
NH
S
NH
Q3a
OH


1394
CH
NEt
Q1w
a bond
Me
a bond
NH
S
NH
Q3b
OH


1395
CH
NEt
Q1w
a bond
Me
a bond
NH
S
NH
Q3c
OH


1396
CH
NEt
Q1w
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1397
CH
NEt
Q1w
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1398
CH
NEt
Q1w
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1399
CH
NEt
Q1w
a bond
Me
a bond
NH
O
NH
Q3a
OH


1400
CH
NEt
Q1w
a bond
Me
a bond
NH
O
NH
Q3b
OH


1401
CH
NEt
Q1w
a bond
Me
a bond
NH
O
NH
Q3c
OH


1402
CH
NEt
Q1w
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1403
CH
NEt
Q1w
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1404
CH
NEt
Q1w
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1405
CH
NEt
Q1w
a bond
H
a bond
NH
S
NH
Q3a
OH


1406
CH
NEt
Q1w
a bond
H
a bond
NH
S
NH
Q3b
OH


1407
CH
NEt
Q1w
a bond
H
a bond
NH
S
NH
Q3c
OH


1408
CH
NEt
Q1w
a bond
H
a bond
NH
S
a bond
Q3a
OH


1409
CH
NEt
Q1w
a bond
H
a bond
NH
S
a bond
Q3b
OH


1410
CH
NEt
Q1w
a bond
H
a bond
NH
S
a bond
Q3c
OH


1411
CH
NEt
Q1w
a bond
H
a bond
NH
O
NH
Q3a
OH


1412
CH
NEt
Q1w
a bond
H
a bond
NH
O
NH
Q3b
OH


1413
CH
NEt
Q1w
a bond
H
a bond
NH
O
NH
Q3c
OH


1414
CH
NEt
Q1w
a bond
H
a bond
NH
O
a bond
Q3a
OH


1415
CH
NEt
Q1w
a bond
H
a bond
NH
O
a bond
Q3b
OH


1416
CH
NEt
Q1w
a bond
H
a bond
NH
O
a bond
Q3c
OH


1417
CH
NEt
Q1x
a bond
Me
a bond
NH
S
NH
Q3a
OH


1418
CH
NEt
Q1x
a bond
Me
a bond
NH
S
NH
Q3b
OH


1419
CH
NEt
Q1x
a bond
Me
a bond
NH
S
NH
Q3c
OH


1420
CH
NEt
Q1x
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1421
CH
NEt
Q1x
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1422
CH
NEt
Q1x
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1423
CH
NEt
Q1x
a bond
Me
a bond
NH
O
NH
Q3a
OH


1424
CH
NEt
Q1x
a bond
Me
a bond
NH
O
NH
Q3b
OH


1425
CH
NEt
Q1x
a bond
Me
a bond
NH
O
NH
Q3c
OH


1426
CH
NEt
Q1x
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1427
CH
NEt
Q1x
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1428
CH
NEt
Q1x
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1429
CH
NEt
Q1x
a bond
H
a bond
NH
S
NH
Q3a
OH


1430
CH
NEt
Q1x
a bond
H
a bond
NH
S
NH
Q3b
OH


1431
CH
NEt
Q1x
a bond
H
a bond
NH
S
NH
Q3c
OH


1432
CH
NEt
Q1x
a bond
H
a bond
NH
S
a bond
Q3a
OH


1433
CH
NEt
Q1x
a bond
H
a bond
NH
S
a bond
Q3b
OH


1434
CH
NEt
Q1x
a bond
H
a bond
NH
S
a bond
Q3c
OH


1435
CH
NEt
Q1x
a bond
H
a bond
NH
O
NH
Q3a
OH


1436
CH
NEt
Q1x
a bond
H
a bond
NH
O
NH
Q3b
OH


1437
CH
NEt
Q1x
a bond
H
a bond
NH
O
NH
Q3c
OH


1438
CH
NEt
Q1x
a bond
H
a bond
NH
O
a bond
Q3a
OH


1439
CH
NEt
Q1x
a bond
H
a bond
NH
O
a bond
Q3b
OH


1440
CH
NEt
Q1x
a bond
H
a bond
NH
O
a bond
Q3c
OH


1441
CH
S
Q1o
a bond
Me
a bond
NH
S
NH
Q3a
OH


1442
CH
S
Q1o
a bond
Me
a bond
NH
S
NH
Q3b
OH


1443
CH
S
Q1o
a bond
Me
a bond
NH
S
NH
Q3c
OH


1444
CH
S
Q1o
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1445
CH
S
Q1o
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1446
CH
S
Q1o
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1447
CH
S
Q1o
a bond
Me
a bond
NH
O
NH
Q3a
OH


1448
CH
S
Q1o
a bond
Me
a bond
NH
O
NH
Q3b
OH


1449
CH
S
Q1o
a bond
Me
a bond
NH
O
NH
.Q3c
OH


1450
CH
S
Q1o
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1451
CH
S
Q1o
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1452
CH
S
Q1o
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1453
CH
S
Q1o
a bond
H
a bond
NH
S
NH
Q3a
OH


1454
CH
S
Q1o
a bond
H
a bond
NH
S
NH
Q3b
OH


1455
CH
S
Q1o
a bond
H
a bond
NH
S
NH
Q3c
OH


1456
CH
S
Q1o
a bond
H
a bond
NH
S
a bond
Q3a
OH


1457
CH
S
Q1o
a bond
H
a bond
NH
S
a bond
Q3b
OH


1458
CH
S
Q1o
a bond
H
a bond
NH
S
a bond
Q3c
OH


1459
CH
S
Q1o
a bond
H
a bond
NH
O
NH
Q3a
OH


1460
CH
S
Q1o
a bond
H
a bond
NH
O
NH
Q3b
OH


1461
CH
S
Q1o
a bond
H
a bond
NH
O
NH
Q3c
OH


1462
CH
S
Q1o
a bond
H
a bond
NH
O
a bond
Q3a
OH


1463
CH
S
Q1o
a bond
H
a bond
NH
O
a bond
Q3b
OH


1464
CH
S
Q1o
a bond
H
a bond
NH
O
a bond
Q3c
OH


1465
CH
S
Q1p
a bond
Me
a bond
NH
S
NH
Q3a
OH


1466
CH
S
Q1p
a bond
Me
a bond
NH
S
NH
Q3b
OH


1467
CH
S
Q1p
a bond
Me
a bond
NH
S
NH
Q3c
OH


1468
CH
S
Q1p
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1469
CH
S
Q1p
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1470
CH
S
Q1p
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1471
CH
S
Q1p
a bond
Me
a bond
NH
O
NH
Q3a
OH


1472
CH
S
Q1p
a bond
Me
a bond
NH
O
NH
Q3b
OH


1473
CH
S
Q1p
a bond
Me
a bond
NH
O
NH
Q3c
OH


1474
CH
S
Q1p
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1475
CH
S
Q1p
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1476
CH
S
Q1p
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1477
CH
S
Q1p
a bond
H
a bond
NH
S
NH
Q3a
OH


1478
CH
S
Q1p
a bond
H
a bond
NH
S
NH
Q3b
OH


1479
CH
S
Q1p
a bond
H
a bond
NH
S
NH
Q3c
OH


1480
CH
S
Q1p
a bond
H
a bond
NH
S
a bond
Q3a
OH


1481
CH
S
Q1p
a bond
H
a bond
NH
S
a bond
Q3b
OH


1482
CH
S
Q1p
a bond
H
a bond
NH
S
a bond
Q3c
OH


1483
CH
S
Q1p
a bond
H
a bond
NH
O
NH
Q3a
OH


1484
CH
S
Q1p
a bond
H
a bond
NH
O
NH
Q3b
OH


1485
CH
S
Q1p
a bond
H
a bond
NH
O
NH
Q3c
OH


1486
CH
S
Q1p
a bond
H
a bond
NH
O
a bond
Q3a
OH


1487
CH
S
Q1p
a bond
H
a bond
NH
O
a bond
Q3b
OH


1488
CH
S
Q1p
a bond
H
a bond
NH
O
a bond
Q3c
OH


1489
CH
S
Q1q
a bond
Me
a bond
NH
S
NH
Q3a
OH


1490
CH
S
Q1q
a bond
Me
a bond
NH
S
NH
Q3b
OH


1491
CH
S
Q1q
a bond
Me
a bond
NH
S
NH
Q3c
OH


1492
CH
S
Q1q
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1493
CH
S
Q1q
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1494
CH
S
Q1q
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1495
CH
S
Q1q
a bond
Me
a bond
NH
O
NH
Q3a
OH


1496
CH
S
Q1q
a bond
Me
a bond
NH
O
NH
Q3b
OH


1497
CH
S
Q1q
a bond
Me
a bond
NH
O
NH
Q3c
OH


1498
CH
S
Q1q
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1499
CH
S
Q1q
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1500
CH
S
Q1q
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1501
CH
S
Q1q
a bond
H
a bond
NH
S
NH
Q3a
OH


1502
CH
S
Q1q
a bond
H
a bond
NH
S
NH
Q3b
OH


1503
CH
S
Q1q
a bond
H
a bond
NH
S
NH
Q3c
OH


1504
CH
S
Q1q
a bond
H
a bond
NH
S
a bond
Q3a
OH


1505
CH
S
Q1q
a bond
H
a bond
NH
S
a bond
Q3b
OH


1506
CH
S
Q1q
a bond
H
a bond
NH
S
a bond
Q3c
OH


1507
CH
S
Q1q
a bond
H
a bond
NH
O
NH
Q3a
OH


1508
CH
S
Q1q
a bond
H
a bond
NH
O
NH
Q3b
OH


1509
CH
S
Q1q
a bond
H
a bond
NH
O
NH
Q3c
OH


1510
CH
S
Q1q
a bond
H
a bond
NH
O
a bond
Q3a
OH


1511
CH
S
Q1q
a bond
H
a bond
NH
O
a bond
Q3b
OH


1512
CH
S
Q1q
a bond
H
a bond
NH
O
a bond
Q3c
OH


1513
CH
S
Q1r
a bond
Me
a bond
NH
S
NH
Q3a
OH


1514
CH
S
Q1r
a bond
Me
a bond
NH
S
NH
Q3b
OH


1515
CH
S
Q1r
a bond
Me
a bond
NH
S
NH
Q3c
OH


1516
CH
S
Q1r
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1517
CH
S
Q1r
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1518
CH
S
Q1r
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1519
CH
S
Q1r
a bond
Me
a bond
NH
O
NH
Q3a
OH


1520
CH
S
Q1r
a bond
Me
a bond
NH
O
NH
Q3b
OH


1521
CH
S
Q1r
a bond
Me
a bond
NH
O
NH
Q3c
OH


1522
CH
S
Q1r
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1523
CH
S
Q1r
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1524
CH
S
Q1r
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1525
CH
S
Q1r
a bond
H
a bond
NH
S
NH
Q3a
OH


1526
CH
S
Q1r
a bond
H
a bond
NH
S
NH
Q3b
OH


1527
CH
S
Q1r
a bond
H
a bond
NH
S
NH
Q3c
OH


1528
CH
S
Q1r
a bond
H
a bond
NH
S
a bond
Q3a
OH


1529
CH
S
Q1r
a bond
H
a bond
NH
S
a bond
Q3b
OH


1530
CH
S
Q1r
a bond
H
a bond
NH
S
a bond
Q3c
OH


1531
CH
S
Q1r
a bond
H
a bond
NH
O
NH
Q3a
OH


1532
CH
S
Q1r
a bond
H
a bond
NH
O
NH
Q3b
OH


1533
CH
S
Q1r
a bond
H
a bond
NH
O
NH
Q3c
OH


1534
CH
S
Q1r
a bond
H
a bond
NH
O
a bond
Q3a
OH


1535
CH
S
Q1r
a bond
H
a bond
NH
O
a bond
Q3b
OH


1536
CH
S
Q1r
a bond
H
a bond
NH
O
a bond
Q3c
OH


1537
CH
S
Q1s
a bond
Me
a bond
NH
S
NH
Q3a
OH


1538
CH
S
Q1s
a bond
Me
a bond
NH
S
NH
Q3b
OH


1539
CH
S
Q1s
a bond
Me
a bond
NH
S
NH
Q3c
OH


1540
CH
S
Q1s
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1541
CH
S
Q1s
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1542
CH
S
Q1s
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1543
CH
S
Q1s
a bond
Me
a bond
NH
O
NH
Q3a
OH


1544
CH
S
Q1s
a bond
Me
a bond
NH
O
NH
Q3b
OH


1545
CH
S
Q1s
a bond
Me
a bond
NH
O
NH
Q3c
OH


1546
CH
S
Q1s
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1547
CH
S
Q1s
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1548
CH
S
Q1s
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1549
CH
S
Q1s
a bond
H
a bond
NH
S
NH
Q3a
OH


1550
CH
S
Q1s
a bond
H
a bond
NH
S
NH
Q3b
OH


1551
CH
S
Q1s
a bond
H
a bond
NH
S
NH
Q3c
OH


1552
CH
S
Q1s
a bond
H
a bond
NH
S
a bond
Q3a
OH


1553
CH
S
Q1s
a bond
H
a bond
NH
S
a bond
Q3b
OH


1554
CH
S
Q1s
a bond
H
a bond
NH
S
a bond
Q3c
OH


1555
CH
S
Q1s
a bond
H
a bond
NH
O
NH
Q3a
OH


1556
CH
S
Q1s
a bond
H
a bond
NH
O
NH
Q3b
OH


1557
CH
S
Q1s
a bond
H
a bond
NH
O
NH
Q3c
OH


1558
CH
S
Q1s
a bond
H
a bond
NH
O
a bond
Q3a
OH


1559
CH
S
Q1s
a bond
H
a bond
NH
O
a bond
Q3b
OH


1560
CH
S
Q1s
a bond
H
a bond
NH
O
a bond
Q3c
OH


1561
CH
S
Q1t
a bond
Me
a bond
NH
S
NH
Q3a
OH


1562
CH
S
Q1t
a bond
Me
a bond
NH
S
NH
Q3b
OH


1563
CH
S
Q1t
a bond
Me
a bond
NH
S
NH
Q3c
OH


1564
CH
S
Q1t
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1565
CH
S
Q1t
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1566
CH
S
Q1t
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1567
CH
S
Q1t
a bond
Me
a bond
NH
O
NH
Q3a
OH


1568
CH
S
Q1t
a bond
Me
a bond
NH
O
NH
Q3b
OH


1569
CH
S
Q1t
a bond
Me
a bond
NH
O
NH
Q3c
OH


1570
CH
S
Q1t
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1571
CH
S
Q1t
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1572
CH
S
Q1t
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1573
CH
S
Q1t
a bond
H
a bond
NH
S
NH
Q3a
OH


1574
CH
S
Q1t
a bond
H
a bond
NH
S
NH
Q3b
OH


1575
CH
S
Q1t
a bond
H
a bond
NH
S
NH
Q3c
OH


1576
CH
S
Q1t
a bond
H
a bond
NH
S
a bond
Q3a
OH


1577
CH
S
Q1t
a bond
H
a bond
NH
S
a bond
Q3b
OH


1578
CH
S
Q1t
a bond
H
a bond
NH
S
a bond
Q3c
OH


1579
CH
S
Q1t
a bond
H
a bond
NH
O
NH
Q3a
OH


1580
CH
S
Q1t
a bond
H
a bond
NH
O
NH
Q3b
OH


1581
CH
S
Q1t
a bond
H
a bond
NH
O
NH
Q3c
OH


1582
CH
S
Q1t
a bond
H
a bond
NH
O
a bond
Q3a
OH


1583
CH
S
Q1t
a bond
H
a bond
NH
O
a bond
Q3b
OH


1584
CH
S
Q1t
a bond
H
a bond
NH
O
a bond
Q3c
OH


1585
CH
S
Q1u
a bond
Me
a bond
NH
S
NH
Q3a
OH


1586
CH
S
Q1u
a bond
Me
a bond
NH
S
NH
Q3b
OH


1587
CH
S
Q1u
a bond
Me
a bond
NH
S
NH
Q3c
OH


1588
CH
S
Q1u
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1589
CH
S
Q1u
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1590
CH
S
Q1u
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1591
CH
S
Q1u
a bond
Me
a bond
NH
O
NH
Q3a
OH


1592
CH
S
Q1u
a bond
Me
a bond
NH
O
NH
Q3b
OH


1593
CH
S
Q1u
a bond
Me
a bond
NH
O
NH
Q3c
OH


1594
CH
S
Q1u
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1595
CH
S
Q1u
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1596
CH
S
Q1u
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1597
CH
S
Q1u
a bond
H
a bond
NH
S
NH
Q3a
OH


1598
CH
S
Q1u
a bond
H
a bond
NH
S
NH
Q3b
OH


1599
CH
S
Q1u
a bond
H
a bond
NH
S
NH
Q3c
OH


1600
CH
S
Q1u
a bond
H
a bond
NH
S
a bond
Q3a
OH


1601
CH
S
Q1u
a bond
H
a bond
NH
S
a bond
Q3b
OH


1602
CH
S
Q1u
a bond
H
a bond
NH
S
a bond
Q3c
OH


1603
CH
S
Q1u
a bond
H
a bond
NH
O
NH
Q3a
OH


1604
CH
S
Q1u
a bond
H
a bond
NH
O
NH
Q3b
OH


1605
CH
S
Q1u
a bond
H
a bond
NH
O
NH
Q3c
OH


1606
CH
S
Q1u
a bond
H
a bond
NH
O
a bond
Q3a
OH


1607
CH
S
Q1u
a bond
H
a bond
NH
O
a bond
Q3b
OH


1608
CH
S
Q1u
a bond
H
a bond
NH
O
a bond
Q3c
OH


1609
CH
S
Q1v
a bond
Me
a bond
NH
S
NH
Q3a
OH


1610
CH
S
Q1v
a bond
Me
a bond
NH
S
NH
Q3b
OH


1611
CH
S
Q1v
a bond
Me
a bond
NH
S
NH
Q3c
OH


1612
CH
S
Q1v
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1613
CH
S
Q1v
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1614
CH
S
Q1v
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1615
CH
S
Q1v
a bond
Me
a bond
NH
O
NH
Q3a
OH


1616
CH
S
Q1v
a bond
Me
a bond
NH
O
NH
Q3b
OH


1617
CH
S
Q1v
a bond
Me
a bond
NH
O
NH
Q3c
OH


1618
CH
S
Q1v
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1619
CH
S
Q1v
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1620
CH
S
Q1v
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1621
CH
S
Q1v
a bond
H
a bond
NH
S
NH
Q3a
OH


1622
CH
S
Q1v
a bond
H
a bond
NH
S
NH
Q3b
OH


1623
CH
S
Q1v
a bond
H
a bond
NH
S
NH
Q3c
OH


1624
CH
S
Q1v
a bond
H
a bond
NH
S
a bond
Q3a
OH


1625
CH
S
Q1v
a bond
H
a bond
NH
S
a bond
Q3b
OH


1626
CH
S
Q1v
a bond
H
a bond
NH
S
a bond
Q3c
OH


1627
CH
S
Q1v
a bond
H
a bond
NH
O
NH
Q3a
OH


1628
CH
S
Q1v
a bond
H
a bond
NH
O
NH
Q3b
OH


1629
CH
S
Q1v
a bond
H
a bond
NH
O
NH
Q3c
OH


1630
CH
S
Q1v
a bond
H
a bond
NH
O
a bond
Q3a
OH


1631
CH
S
Q1v
a bond
H
a bond
NH
O
a bond
Q3b
OH


1632
CH
S
Q1v
a bond
H
a bond
NH
O
a bond
Q3c
OH


1633
CH
S
Q1w
a bond
Me
a bond
NH
S
NH
Q3a
OH


1634
CH
S
Q1w
a bond
Me
a bond
NH
S
NH
Q3b
OH


1635
CH
S
Q1w
a bond
Me
a bond
NH
S
NH
Q3c
OH


1636
CH
S
Q1w
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1637
CH
S
Q1w
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1638
CH
S
Q1w
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1639
CH
S
Q1w
a bond
Me
a bond
NH
O
NH
Q3a
OH


1640
CH
S
Q1w
a bond
Me
a bond
NH
O
NH
Q3b
OH


1641
CH
S
Q1w
a bond
Me
a bond
NH
O
NH
Q3c
OH


1642
CH
S
Q1w
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1643
CH
S
Q1w
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1644
CH
S
Q1w
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1645
CH
S
Q1w
a bond
H
a bond
NH
S
NH
Q3a
OH


1646
CH
S
Q1w
a bond
H
a bond
NH
S
NH
Q3b
OH


1647
CH
S
Q1w
a bond
H
a bond
NH
S
NH
Q3c
OH


1648
CH
S
Q1w
a bond
H
a bond
NH
S
a bond
Q3a
OH


1649
CH
S
Q1w
a bond
H
a bond
NH
S
a bond
Q3b
OH


1650
CH
S
Q1w
a bond
H
a bond
NH
S
a bond
Q3c
OH


1651
CH
S
Q1w
a bond
H
a bond
NH
O
NH
Q3a
OH


1652
CH
S
Q1w
a bond
H
a bond
NH
O
NH
Q3b
OH


1653
CH
S
Q1w
a bond
H
a bond
NH
O
NH
Q3c
OH


1654
CH
S
Q1w
a bond
H
a bond
NH
O
a bond
Q3a
OH


1655
CH
S
Q1w
a bond
H
a bond
NH
O
a bond
Q3b
OH


1656
CH
S
Q1w
a bond
H
a bond
NH
O
a bond
Q3c
OH


1657
CH
S
Q1x
a bond
Me
a bond
NH
S
NH
Q3a
OH


1658
CH
S
Q1x
a bond
Me
a bond
NH
S
NH
Q3b
OH


1659
CH
S
Q1x
a bond
Me
a bond
NH
S
NH
Q3c
OH


1660
CH
S
Q1x
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1661
CH
S
Q1x
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1662
CH
S
Q1x
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1663
CH
S
Q1x
a bond
Me
a bond
NH
O
NH
Q3a
OH


1664
CH
S
Q1x
a bond
Me
a bond
NH
O
NH
Q3b
OH


1665
CH
S
Q1x
a bond
Me
a bond
NH
O
NH
Q3c
OH


1666
CH
S
Q1x
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1667
CH
S
Q1x
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1668
CH
S
Q1x
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1669
CH
S
Q1x
a bond
H
a bond
NH
S
NH
Q3a
OH


1670
CH
S
Q1x
a bond
H
a bond
NH
S
NH
Q3b
OH


1671
CH
S
Q1x
a bond
H
a bond
NH
S
NH
Q3c
OH


1672
CH
S
Q1x
a bond
H
a bond
NH
S
a bond
Q3a
OH


1673
CH
S
Q1x
a bond
H
a bond
NH
S
a bond
Q3b
OH


1674
CH
S
Q1x
a bond
H
a bond
NH
S
a bond
Q3c
OH


1675
CH
S
Q1x
a bond
H
a bond
NH
O
NH
Q3a
OH


1676
CH
S
Q1x
a bond
H
a bond
NH
O
NH
Q3b
OH


1677
CH
S
Q1x
a bond
H
a bond
NH
O
NH
Q3c
OH


1678
CH
S
Q1x
a bond
H
a bond
NH
O
a bond
Q3a
OH


1679
CH
S
Q1x
a bond
H
a bond
NH
O
a bond
Q3b
OH


1680
CH
S
Q1x
a bond
H
a bond
NH
O
a bond
Q3c
OH


1681
CH
O
Q1o
a bond
Me
a bond
NH
S
NH
Q3a
OH


1682
CH
O
Q1o
a bond
Me
a bond
NH
S
NH
Q3b
OH


1683
CH
O
Q1o
a bond
Me
a bond
NH
S
NH
Q3c
OH


1684
CH
O
Q1o
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1685
CH
O
Q1o
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1686
CH
O
Q1o
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1687
CH
O
Q1o
a bond
Me
a bond
NH
O
NH
Q3a
OH


1688
CH
O
Q1o
a bond
Me
a bond
NH
O
NH
Q3b
OH


1689
CH
O
Q1o
a bond
Me
a bond
NH
O
NH
Q3c
OH


1690
CH
O
Q1o
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1691
CH
O
Q1o
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1692
CH
O
Q1o
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1693
CH
O
Q1o
a bond
H
a bond
NH
S
NH
Q3a
OH


1694
CH
O
Q1o
a bond
H
a bond
NH
S
NH
Q3b
OH


1695
CH
O
Q1o
a bond
H
a bond
NH
S
NH
Q3c
OH


1696
CH
O
Q1o
a bond
H
a bond
NH
S
a bond
Q3a
OH


1697
CH
O
Q1o
a bond
H
a bond
NH
S
a bond
Q3b
OH


1698
CH
O
Q1o
a bond
H
a bond
NH
S
a bond
Q3c
OH


1699
CH
O
Q1o
a bond
H
a bond
NH
O
NH
Q3a
OH


1700
CH
O
Q1o
a bond
H
a bond
NH
O
NH
Q3b
OH


1701
CH
O
Q1o
a bond
H
a bond
NH
O
NH
Q3c
OH


1702
CH
O
Q1o
a bond
H
a bond
NH
O
a bond
Q3a
OH


1703
CH
O
Q1o
a bond
H
a bond
NH
O
a bond
Q3b
OH


1704
CH
O
Q1o
a bond
H
a bond
NH
O
a bond
Q3c
OH


1705
CH
O
Q1p
a bond
Me
a bond
NH
S
NH
Q3a
OH


1706
CH
O
Q1p
a bond
Me
a bond
NH
S
NH
Q3b
OH


1707
CH
O
Q1p
a bond
Me
a bond
NH
S
NH
Q3c
OH


1708
CH
O
Q1p
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1709
CH
O
Q1p
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1710
CH
O
Q1p
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1711
CH
O
Q1p
a bond
Me
a bond
NH
O
NH
Q3a
OH


1712
CH
O
Q1p
a bond
Me
a bond
NH
O
NH
Q3b
OH


1713
CH
O
Q1p
a bond
Me
a bond
NH
O
NH
Q3c
OH


1714
CH
O
Q1p
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1715
CH
O
Q1p
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1716
CH
O
Q1p
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1717
CH
O
Q1p
a bond
H
a bond
NH
S
NH
Q3a
OH


1718
CH
O
Q1p
a bond
H
a bond
NH
S
NH
Q3b
OH


1719
CH
O
Q1p
a bond
H
a bond
NH
S
NH
Q3c
OH


1720
CH
O
Q1p
a bond
H
a bond
NH
S
a bond
Q3a
OH


1721
CH
O
Q1p
a bond
H
a bond
NH
S
a bond
Q3b
OH


1722
CH
O
Q1p
a bond
H
a bond
NH
S
a bond
Q3c
OH


1723
CH
O
Q1p
a bond
H
a bond
NH
O
NH
Q3a
OH


1724
CH
O
Q1p
a bond
H
a bond
NH
O
NH
Q3b
OH


1725
CH
O
Q1p
a bond
H
a bond
NH
O
NH
Q3c
OH


1726
CH
O
Q1p
a bond
H
a bond
NH
O
a bond
Q3a
OH


1727
CH
O
Q1p
a bond
H
a bond
NH
O
a bond
Q3b
OH


1728
CH
O
Q1p
a bond
H
a bond
NH
O
a bond
Q3c
OH


1729
CH
O
Q1q
a bond
Me
a bond
NH
S
NH
Q3a
OH


1730
CH
O
Q1q
a bond
Me
a bond
NH
S
NH
Q3b
OH


1731
CH
O
Q1q
a bond
Me
a bond
NH
S
NH
Q3c
OH


1732
CH
O
Q1q
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1733
CH
O
Q1q
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1734
CH
O
Q1q
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1735
CH
O
Q1q
a bond
Me
a bond
NH
O
NH
Q3a
OH


1736
CH
O
Q1q
a bond
Me
a bond
NH
O
NH
Q3b
OH


1737
CH
O
Q1q
a bond
Me
a bond
NH
O
NH
Q3c
OH


1738
CH
O
Q1q
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1739
CH
O
Q1q
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1740
CH
O
Q1q
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1741
CH
O
Q1q
a bond
H
a bond
NH
S
NH
Q3a
OH


1742
CH
O
Q1q
a bond
H
a bond
NH
S
NH
Q3b
OH


1743
CH
O
Q1q
a bond
H
a bond
NH
S
NH
Q3c
OH


1744
CH
O
Q1q
a bond
H
a bond
NH
S
a bond
Q3a
OH


1745
CH
O
Q1q
a bond
H
a bond
NH
S
a bond
Q3b
OH


1746
CH
O
Q1q
a bond
H
a bond
NH
S
a bond
Q3c
OH


1747
CH
O
Q1q
a bond
H
a bond
NH
O
NH
Q3a
OH


1748
CH
O
Q1q
a bond
H
a bond
NH
O
NH
Q3b
OH


1749
CH
O
Q1q
a bond
H
a bond
NH
O
NH
Q3c
OH


1750
CH
O
Q1q
a bond
H
a bond
NH
O
a bond
Q3a
OH


1751
CH
O
Q1q
a bond
H
a bond
NH
O
a bond
Q3b
OH


1752
CH
O
Q1q
a bond
H
a bond
NH
O
a bond
Q3c
OH


1753
CH
O
Q1r
a bond
Me
a bond
NH
S
NH
Q3a
OH


1754
CH
O
Q1r
a bond
Me
a bond
NH
S
NH
Q3b
OH


1755
CH
O
Q1r
a bond
Me
a bond
NH
S
NH
Q3c
OH


1756
CH
O
Q1r
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1757
CH
O
Q1r
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1758
CH
O
Q1r
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1759
CH
O
Q1r
a bond
Me
a bond
NH
O
NH
Q3a
OH


1760
CH
O
Q1r
a bond
Me
a bond
NH
O
NH
Q3b
OH


1761
CH
O
Q1r
a bond
Me
a bond
NH
O
NH
Q3c
OH


1762
CH
O
Q1r
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1763
CH
O
Q1r
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1764
CH
O
Q1r
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1765
CH
O
Q1r
a bond
H
a bond
NH
S
NH
Q3a
OH


1766
CH
O
Q1r
a bond
H
a bond
NH
S
NH
Q3b
OH


1767
CH
O
Q1r
a bond
H
a bond
NH
S
NH
Q3c
OH


1768
CH
O
Q1r
a bond
H
a bond
NH
S
a bond
Q3a
OH


1769
CH
O
Q1r
a bond
H
a bond
NH
S
a bond
Q3b
OH


1770
CH
O
Q1r
a bond
H
a bond
NH
S
a bond
Q3c
OH


1771
CH
O
Q1r
a bond
H
a bond
NH
O
NH
Q3a
OH


1772
CH
O
Q1r
a bond
H
a bond
NH
O
NH
Q3b
OH


1773
CH
O
Q1r
a bond
H
a bond
NH
O
NH
Q3c
OH


1774
CH
O
Q1r
a bond
H
a bond
NH
O
a bond
Q3a
OH


1775
CH
O
Q1r
a bond
H
a bond
NH
O
a bond
Q3b
OH


1776
CH
O
Q1r
a bond
H
a bond
NH
O
a bond
Q3c
OH


1777
CH
O
Q1s
a bond
Me
a bond
NH
S
NH
Q3a
OH


1778
CH
O
Q1s
a bond
Me
a bond
NH
S
NH
Q3b
OH


1779
CH
O
Q1s
a bond
Me
a bond
NH
S
NH
Q3c
OH


1780
CH
O
Q1s
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1781
CH
O
Q1s
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1782
CH
O
Q1s
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1783
CH
O
Q1s
a bond
Me
a bond
NH
O
NH
Q3a
OH


1784
CH
O
Q1s
a bond
Me
a bond
NH
O
NH
Q3b
OH


1785
CH
O
Q1s
a bond
Me
a bond
NH
O
NH
Q3c
OH


1786
CH
O
Q1s
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1787
CH
O
Q1s
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1788
CH
O
Q1s
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1789
CH
O
Q1s
a bond
H
a bond
NH
S
NH
Q3a
OH


1790
CH
O
Q1s
a bond
H
a bond
NH
S
NH
Q3b
OH


1791
CH
O
Q1s
a bond
H
a bond
NH
S
NH
Q3c
OH


1792
CH
O
Q1s
a bond
H
a bond
NH
S
a bond
Q3a
OH


1793
CH
O
Q1s
a bond
H
a bond
NH
S
a bond
Q3b
OH


1794
CH
O
Q1s
a bond
H
a bond
NH
S
a bond
Q3c
OH


1795
CH
O
Q1s
a bond
H
a bond
NH
O
NH
Q3a
OH


1796
CH
O
Q1s
a bond
H
a bond
NH
O
NH
Q3b
OH


1797
CH
O
Q1s
a bond
H
a bond
NH
O
NH
Q3c
OH


1798
CH
O
Q1s
a bond
H
a bond
NH
O
a bond
Q3a
OH


1799
CH
O
Q1s
a bond
H
a bond
NH
O
a bond
Q3b
OH


1800
CH
O
Q1s
a bond
H
a bond
NH
O
a bond
Q3c
OH


1801
CH
O
Q1t
a bond
Me
a bond
NH
S
NH
Q3a
OH


1802
CH
O
Q1t
a bond
Me
a bond
NH
S
NH
Q3b
OH


1803
CH
O
Q1t
a bond
Me
a bond
NH
S
NH
Q3c
OH


1804
CH
O
Q1t
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1805
CH
O
Q1t
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1806
CH
O
Q1t
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1807
CH
O
Q1t
a bond
Me
a bond
NH
O
NH
Q3a
OH


1808
CH
O
Q1t
a bond
Me
a bond
NH
O
NH
Q3b
OH


1809
CH
O
Q1t
a bond
Me
a bond
NH
O
NH
Q3c
OH


1810
CH
O
Q1t
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1811
CH
O
Q1t
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1812
CH
O
Q1t
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1813
CH
O
Q1t
a bond
H
a bond
NH
S
NH
Q3a
OH


1814
CH
O
Q1t
a bond
H
a bond
NH
S
NH
Q3b
OH


1815
CH
O
Q1t
a bond
H
a bond
NH
S
NH
Q3c
OH


1816
CH
O
Q1t
a bond
H
a bond
NH
S
a bond
Q3a
OH


1817
CH
O
Q1t
a bond
H
a bond
NH
S
a bond
Q3b
OH


1818
CH
O
Q1t
a bond
H
a bond
NH
S
a bond
Q3c
OH


1819
CH
O
Q1t
a bond
H
a bond
NH
O
NH
Q3a
OH


1820
CH
O
Q1t
a bond
H
a bond
NH
O
NH
Q3b
OH


1821
CH
O
Q1t
a bond
H
a bond
NH
O
NH
Q3c
OH


1822
CH
O
Q1t
a bond
H
a bond
NH
O
a bond
Q3a
OH


1823
CH
O
Q1t
a bond
H
a bond
NH
O
a bond
Q3b
OH


1824
CH
O
Q1t
a bond
H
a bond
NH
O
a bond
Q3c
OH


1825
CH
O
Q1u
a bond
Me
a bond
NH
S
NH
Q3a
OH


1826
CH
O
Q1u
a bond
Me
a bond
NH
S
NH
Q3b
OH


1827
CH
O
Q1u
a bond
Me
a bond
NH
S
NH
Q3c
OH


1828
CH
O
Q1u
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1829
CH
O
Q1u
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1830
CH
O
Q1u
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1831
CH
O
Q1u
a bond
Me
a bond
NH
O
NH
Q3a
OH


1832
CH
O
Q1u
a bond
Me
a bond
NH
O
NH
Q3b
OH


1833
CH
O
Q1u
a bond
Me
a bond
NH
O
NH
Q3c
OH


1834
CH
O
Q1u
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1835
CH
O
Q1u
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1836
CH
O
Q1u
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1837
CH
O
Q1u
a bond
H
a bond
NH
S
NH
Q3a
OH


1838
CH
O
Q1u
a bond
H
a bond
NH
S
NH
Q3b
OH


1839
CH
O
Q1u
a bond
H
a bond
NH
S
NH
Q3c
OH


1840
CH
O
Q1u
a bond
H
a bond
NH
S
a bond
Q3a
OH


1841
CH
O
Q1u
a bond
H
a bond
NH
S
a bond
Q3b
OH


1842
CH
O
Q1u
a bond
H
a bond
NH
S
a bond
Q3c
OH


1843
CH
O
Q1u
a bond
H
a bond
NH
O
NH
Q3a
OH


1844
CH
O
Q1u
a bond
H
a bond
NH
O
NH
Q3b
OH


1845
CH
O
Q1u
a bond
H
a bond
NH
O
NH
Q3c
OH


1846
CH
O
Q1u
a bond
H
a bond
NH
O
a bond
Q3a
OH


1847
CH
O
Q1u
a bond
H
a bond
NH
O
a bond
Q3b
OH


1848
CH
O
Q1u
a bond
H
a bond
NH
O
a bond
Q3c
OH


1849
CH
O
Q1v
a bond
Me
a bond
NH
S
NH
Q3a
OH


1850
CH
O
Q1v
a bond
Me
a bond
NH
S
NH
Q3b
OH


1851
CH
O
Q1v
a bond
Me
a bond
NH
S
NH
Q3c
OH


1852
CH
O
Q1v
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1853
CH
O
Q1v
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1854
CH
O
Q1v
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1855
CH
O
Q1v
a bond
Me
a bond
NH
O
NH
Q3a
OH


1856
CH
O
Q1v
a bond
Me
a bond
NH
O
NH
Q3b
OH


1857
CH
O
Q1v
a bond
Me
a bond
NH
O
NH
Q3c
OH


1858
CH
O
Q1v
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1859
CH
O
Q1v
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1860
CH
O
Q1v
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1861
CH
O
Q1v
a bond
H
a bond
NH
S
NH
Q3a
OH


1862
CH
O
Q1v
a bond
H
a bond
NH
S
NH
Q3b
OH


1863
CH
O
Q1v
a bond
H
a bond
NH
S
NH
Q3c
OH


1864
CH
O
Q1v
a bond
H
a bond
NH
S
a bond
Q3a
OH


1865
CH
O
Q1v
a bond
H
a bond
NH
S
a bond
Q3b
OH


1866
CH
O
Q1v
a bond
H
a bond
NH
S
a bond
Q3c
OH


1867
CH
O
Q1v
a bond
H
a bond
NH
O
NH
Q3a
OH


1868
CH
O
Q1v
a bond
H
a bond
NH
O
NH
Q3b
OH


1869
CH
O
Q1v
a bond
H
a bond
NH
O
NH
Q3c
OH


1870
CH
O
Q1v
a bond
H
a bond
NH
O
a bond
Q3a
OH


1871
CH
O
Q1v
a bond
H
a bond
NH
O
a bond
Q3b
OH


1872
CH
O
Q1v
a bond
H
a bond
NH
O
a bond
Q3c
OH


1873
CH
O
Q1w
a bond
Me
a bond
NH
S
NH
Q3a
OH


1874
CH
O
Q1w
a bond
Me
a bond
NH
S
NH
Q3b
OH


1875
CH
O
Q1w
a bond
Me
a bond
NH
S
NH
Q3c
OH


1876
CH
O
Q1w
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1877
CH
O
Q1w
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1878
CH
O
Q1w
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1879
CH
O
Q1w
a bond
Me
a bond
NH
O
NH
Q3a
OH


1880
CH
O
Q1w
a bond
Me
a bond
NH
O
NH
Q3b
OH


1881
CH
O
Q1w
a bond
Me
a bond
NH
O
NH
Q3c
OH


1882
CH
O
Q1w
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1883
CH
O
Q1w
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1884
CH
O
Q1w
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1885
CH
O
Q1w
a bond
H
a bond
NH
S
NH
Q3a
OH


1886
CH
O
Q1w
a bond
H
a bond
NH
S
NH
Q3b
OH


1887
CH
O
Q1w
a bond
H
a bond
NH
S
NH
Q3c
OH


1888
CH
O
Q1w
a bond
H
a bond
NH
S
a bond
Q3a
OH


1889
CH
O
Q1w
a bond
H
a bond
NH
S
a bond
Q3b
OH


1890
CH
O
Q1w
a bond
H
a bond
NH
S
a bond
Q3c
OH


1891
CH
O
Q1w
a bond
H
a bond
NH
O
NH
Q3a
OH


1892
CH
O
Q1w
a bond
H
a bond
NH
O
NH
Q3b
OH


1893
CH
O
Q1w
a bond
H
a bond
NH
O
NH
Q3c
OH


1894
CH
O
Q1w
a bond
H
a bond
NH
O
a bond
Q3a
OH


1895
CH
O
Q1w
a bond
H
a bond
NH
O
a bond
Q3b
OH


1896
CH
O
Q1w
a bond
H
a bond
NH
O
a bond
Q3c
OH


1897
CH
O
Q1x
a bond
Me
a bond
NH
S
NH
Q3a
OH


1898
CH
O
Q1x
a bond
Me
a bond
NH
S
NH
Q3b
OH


1899
CH
O
Q1x
a bond
Me
a bond
NH
S
NH
Q3c
OH


1900
CH
O
Q1x
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1901
CH
O
Q1x
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1902
CH
O
Q1x
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1903
CH
O
Q1x
a bond
Me
a bond
NH
O
NH
Q3a
OH


1904
CH
O
Q1x
a bond
Me
a bond
NH
O
NH
Q3b
OH


1905
CH
O
Q1x
a bond
Me
a bond
NH
O
NH
Q3c
OH


1906
CH
O
Q1x
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1907
CH
O
Q1x
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1908
CH
O
Q1x
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1909
CH
O
Q1x
a bond
H
a bond
NH
S
NH
Q3a
OH


1910
CH
O
Q1x
a bond
H
a bond
NH
S
NH
Q3b
OH


1911
CH
O
Q1x
a bond
H
a bond
NH
S
NH
Q3c
OH


1912
CH
O
Q1x
a bond
H
a bond
NH
S
a bond
Q3a
OH


1913
CH
O
Q1x
a bond
H
a bond
NH
S
a bond
Q3b
OH


1914
CH
O
Q1x
a bond
H
a bond
NH
S
a bond
Q3c
OH


1915
CH
O
Q1x
a bond
H
a bond
NH
O
NH
Q3a
OH


1916
CH
O
Q1x
a bond
H
a bond
NH
O
NH
Q3b
OH


1917
CH
O
Q1x
a bond
H
a bond
NH
O
NH
Q3c
OH


1918
CH
O
Q1x
a bond
H
a bond
NH
O
a bond
Q3a
OH


1919
CH
O
Q1x
a bond
H
a bond
NH
O
a bond
Q3b
OH


1920
CH
O
Q1x
a bond
H
a bond
NH
O
a bond
Q3c
OH


1921
CMe
NMe
Q1o
a bond
Me
a bond
NH
S
NH
Q3a
OH


1922
CMe
NMe
Q1o
a bond
Me
a bond
NH
S
NH
Q3b
OH


1923
CMe
NMe
Q1o
a bond
Me
a bond
NH
S
NH
Q3c
OH


1924
CMe
NMe
Q1o
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1925
CMe
NMe
Q1o
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1926
CMe
NMe
Q1o
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1927
CMe
NMe
Q1o
a bond
Me
a bond
NH
O
NH
Q3a
OH


1928
CMe
NMe
Q1o
a bond
Me
a bond
NH
O
NH
Q3b
OH


1929
CMe
NMe
Q1o
a bond
Me
a bond
NH
O
NH
Q3c
OH


1930
CMe
NMe
Q1o
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1931
CMe
NMe
Q1o
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1932
CMe
NMe
Q1o
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1933
CMe
NMe
Q1o
a bond
H
a bond
NH
S
NH
Q3a
OH


1934
CMe
NMe
Q1o
a bond
H
a bond
NH
S
NH
Q3b
OH


1935
CMe
NMe
Q1o
a bond
H
a bond
NH
S
NH
Q3c
OH


1936
CMe
NMe
Q1o
a bond
H
a bond
NH
S
a bond
Q3a
OH


1937
CMe
NMe
Q1o
a bond
H
a bond
NH
S
a bond
Q3b
OH


1938
CMe
NMe
Q1o
a bond
H
a bond
NH
S
a bond
Q3c
OH


1939
CMe
NMe
Q1o
a bond
H
a bond
NH
O
NH
Q3a
OH


1940
CMe
NMe
Q1o
a bond
H
a bond
NH
O
NH
Q3b
OH


1941
CMe
NMe
Q1o
a bond
H
a bond
NH
O
NH
Q3c
OH


1942
CMe
NMe
Q1o
a bond
H
a bond
NH
O
a bond
Q3a
OH


1943
CMe
NMe
Q1o
a bond
H
a bond
NH
O
a bond
Q3b
OH


1944
CMe
NMe
Q1o
a bond
H
a bond
NH
O
a bond
Q3c
OH


1945
CMe
NMe
Q1p
a bond
Me
a bond
NH
S
NH
Q3a
OH


1946
CMe
NMe
Q1p
a bond
Me
a bond
NH
S
NH
Q3b
OH


1947
CMe
NMe
Q1p
a bond
Me
a bond
NH
S
NH
Q3c
OH


1948
CMe
NMe
Q1p
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1949
CMe
NMe
Q1p
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1950
CMe
NMe
Q1p
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1951
CMe
NMe
Q1p
a bond
Me
a bond
NH
O
NH
Q3a
OH


1952
CMe
NMe
Q1p
a bond
Me
a bond
NH
O
NH
Q3b
OH


1953
CMe
NMe
Q1p
a bond
Me
a bond
NH
O
NH
Q3c
OH


1954
CMe
NMe
Q1p
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1955
CMe
NMe
Q1p
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1956
CMe
NMe
Q1p
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1957
CMe
NMe
Q1p
a bond
H
a bond
NH
S
NH
Q3a
OH


1958
CMe
NMe
Q1p
a bond
H
a bond
NH
S
NH
Q3b
OH


1959
CMe
NMe
Q1p
a bond
H
a bond
NH
S
NH
Q3c
OH


1960
CMe
NMe
Q1p
a bond
H
a bond
NH
S
a bond
Q3a
OH


1961
CMe
NMe
Q1p
a bond
H
a bond
NH
S
a bond
Q3b
OH


1962
CMe
NMe
Q1p
a bond
H
a bond
NH
S
a bond
Q3c
OH


1963
CMe
NMe
Q1p
a bond
H
a bond
NH
O
NH
Q3a
OH


1964
CMe
NMe
Q1p
a bond
H
a bond
NH
O
NH
Q3b
OH


1965
CMe
NMe
Q1p
a bond
H
a bond
NH
O
NH
Q3c
OH


1966
CMe
NMe
Q1p
a bond
H
a bond
NH
O
a bond
Q3a
OH


1967
CMe
NMe
Q1p
a bond
H
a bond
NH
O
a bond
Q3b
OH


1968
CMe
NMe
Q1p
a bond
H
a bond
NH
O
a bond
Q3c
OH


1969
CMe
NMe
Q1q
a bond
Me
a bond
NH
S
NH
Q3a
OH


1970
CMe
NMe
Q1q
a bond
Me
a bond
NH
S
NH
Q3b
OH


1971
CMe
NMe
Q1q
a bond
Me
a bond
NH
S
NH
Q3c
OH


1972
CMe
NMe
Q1q
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1973
CMe
NMe
Q1q
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1974
CMe
NMe
Q1q
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1975
CMe
NMe
Q1q
a bond
Me
a bond
NH
O
NH
Q3a
OH


1976
CMe
NMe
Q1q
a bond
Me
a bond
NH
O
NH
Q3b
OH


1977
CMe
NMe
Q1q
a bond
Me
a bond
NH
O
NH
Q3c
OH


1978
CMe
NMe
Q1p
a bond
Me
a bond
NH
O
a bond
Q3a
OH


1979
CMe
NMe
Q1q
a bond
Me
a bond
NH
O
a bond
Q3b
OH


1980
CMe
NMe
Q1q
a bond
Me
a bond
NH
O
a bond
Q3c
OH


1981
CMe
NMe
Q1q
a bond
H
a bond
NH
S
NH
Q3a
OH


1982
CMe
NMe
Q1q
a bond
H
a bond
NH
S
NH
Q3b
OH


1983
CMe
NMe
Q1q
a bond
H
a bond
NH
S
NH
Q3c
OH


1984
CMe
NMe
Q1q
a bond
H
a bond
NH
S
a bond
Q3a
OH


1985
CMe
NMe
Q1q
a bond
H
a bond
NH
S
a bond
Q3b
OH


1986
CMe
NMe
Q1q
a bond
H
a bond
NH
S
a bond
Q3c
OH


1987
CMe
NMe
Q1q
a bond
H
a bond
NH
O
NH
Q3a
OH


1988
CMe
NMe
Q1q
a bond
H
a bond
NH
O
NH
Q3b
OH


1989
CMe
NMe
Q1q
a bond
H
a bond
NH
O
NH
Q3c
OH


1990
CMe
NMe
Q1q
a bond
H
a bond
NH
O
a bond
Q3a
OH


1991
CMe
NMe
Q1q
a bond
H
a bond
NH
O
a bond
Q3b
OH


1992
CMe
NMe
Q1q
a bond
H
a bond
NH
O
a bond
Q3c
OH


1993
CMe
NMe
Q1r
a bond
Me
a bond
NH
S
NH
Q3a
OH


1994
CMe
NMe
Q1r
a bond
Me
a bond
NH
S
NH
Q3b
OH


1995
CMe
NMe
Q1r
a bond
Me
a bond
NH
S
NH
Q3c
OH


1996
CMe
NMe
Q1r
a bond
Me
a bond
NH
S
a bond
Q3a
OH


1997
CMe
NMe
Q1r
a bond
Me
a bond
NH
S
a bond
Q3b
OH


1998
CMe
NMe
Q1r
a bond
Me
a bond
NH
S
a bond
Q3c
OH


1999
CMe
NMe
Q1r
a bond
Me
a bond
NH
O
NH
Q3a
OH


2000
CMe
NMe
Q1r
a bond
Me
a bond
NH
O
NH
Q3b
OH


2001
CMe
NMe
Q1r
a bond
Me
a bond
NH
O
NH
Q3c
OH


2002
CMe
NMe
Q1r
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2003
CMe
NMe
Q1r
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2004
CMe
NMe
Q1r
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2005
CMe
NMe
Q1r
a bond
H
a bond
NH
S
NH
Q3a
OH


2006
CMe
NMe
Q1r
a bond
H
a bond
NH
S
NH
Q3b
OH


2007
CMe
NMe
Q1r
a bond
H
a bond
NH
S
NH
Q3c
OH


2008
CMe
NMe
Q1r
a bond
H
a bond
NH
S
a bond
Q3a
OH


2009
CMe
NMe
Q1r
a bond
H
a bond
NH
S
a bond
Q3b
OH


2010
CMe
NMe
Q1r
a bond
H
a bond
NH
S
a bond
Q3c
OH


2011
CMe
NMe
Q1r
a bond
H
a bond
NH
O
NH
Q3a
OH


2012
CMe
NMe
Q1r
a bond
H
a bond
NH
O
NH
Q3b
OH


2013
CMe
NMe
Q1r
a bond
H
a bond
NH
O
NH
Q3c
OH


2014
CMe
NMe
Q1r
a bond
H
a bond
NH
O
a bond
Q3a
OH


2015
CMe
NMe
Q1r
a bond
H
a bond
NH
O
a bond
Q3b
OH


2016
CMe
NMe
Q1r
a bond
H
a bond
NH
O
a bond
Q3c
OH


2017
CMe
NMe
Q1s
a bond
Me
a bond
NH
S
NH
Q3a
OH


2018
CMe
NMe
Q1s
a bond
Me
a bond
NH
S
NH
Q3b
OH


2019
CMe
NMe
Q1s
a bond
Me
a bond
NH
S
NH
Q3c
OH


2020
CMe
NMe
Q1s
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2021
CMe
NMe
Q1s
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2022
CMe
NMe
Q1s
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2023
CMe
NMe
Q1s
a bond
Me
a bond
NH
O
NH
Q3a
OH


2024
CMe
NMe
Q1s
a bond
Me
a bond
NH
O
NH
Q3b
OH


2025
CMe
NMe
Q1s
a bond
Me
a bond
NH
O
NH
Q3c
OH


2026
CMe
NMe
Q1s
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2027
CMe
NMe
Q1s
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2028
CMe
NMe
Q1s
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2029
CMe
NMe
Q1s
a bond
H
a bond
NH
S
NH
Q3a
OH


2030
CMe
NMe
Q1s
a bond
H
a bond
NH
S
NH
Q3b
OH


2031
CMe
NMe
Q1s
a bond
H
a bond
NH
S
NH
Q3c
OH


2032
CMe
NMe
Q1s
a bond
H
a bond
NH
S
a bond
Q3a
OH


2033
CMe
NMe
Q1s
a bond
H
a bond
NH
S
a bond
Q3b
OH


2034
CMe
NMe
Q1s
a bond
H
a bond
NH
S
a bond
Q3c
OH


2035
CMe
NMe
Q1s
a bond
H
a bond
NH
O
NH
Q3a
OH


2036
CMe
NMe
Q1s
a bond
H
a bond
NH
O
NH
Q3b
OH


2037
CMe
NMe
Q1s
a bond
H
a bond
NH
O
NH
Q3c
OH


2038
CMe
NMe
Q1s
a bond
H
a bond
NH
O
a bond
Q3a
OH


2039
CMe
NMe
Q1s
a bond
H
a bond
NH
O
a bond
Q3b
OH


2040
CMe
NMe
Q1s
a bond
H
a bond
NH
O
a bond
Q3c
OH


2041
CMe
NMe
Q1t
a bond
Me
a bond
NH
S
NH
Q3a
OH


2042
CMe
NMe
Q1t
a bond
Me
a bond
NH
S
NH
Q3b
OH


2043
CMe
NMe
Q1t
a bond
Me
a bond
NH
S
NH
Q3c
OH


2044
CMe
NMe
Q1t
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2045
CMe
NMe
Q1t
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2046
CMe
NMe
Q1t
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2047
CMe
NMe
Q1t
a bond
Me
a bond
NH
O
NH
Q3a
OH


2048
CMe
NMe
Q1t
a bond
Me
a bond
NH
O
NH
Q3b
OH


2049
CMe
NMe
Q1t
a bond
Me
a bond
NH
O
NH
Q3c
OH


2050
CMe
NMe
Q1t
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2051
CMe
NMe
Q1t
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2052
CMe
NMe
Q1t
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2053
CMe
NMe
Q1t
a bond
H
a bond
NH
S
NH
Q3a
OH


2054
CMe
NMe
Q1t
a bond
H
a bond
NH
S
NH
Q3b
OH


2055
CMe
NMe
Q1t
a bond
H
a bond
NH
S
NH
Q3c
OH


2056
CMe
NMe
Q1t
a bond
H
a bond
NH
S
a bond
Q3a
OH


2057
CMe
NMe
Q1t
a bond
H
a bond
NH
S
a bond
Q3b
OH


2058
CMe
NMe
Q1t
a bond
H
a bond
NH
S
a bond
Q3c
OH


2059
CMe
NMe
Q1t
a bond
H
a bond
NH
O
NH
Q3a
OH


2060
CMe
NMe
Q1t
a bond
H
a bond
NH
O
NH
Q3b
OH


2061
CMe
NMe
Q1t
a bond
H
a bond
NH
O
NH
Q3c
OH


2062
CMe
NMe
Q1t
a bond
H
a bond
NH
O
a bond
Q3a
OH


2063
CMe
NMe
Q1t
a bond
H
a bond
NH
O
a bond
Q3b
OH


2064
CMe
NMe
Q1t
a bond
H
a bond
NH
O
a bond
Q3c
OH


2065
CMe
NMe
Q1u
a bond
Me
a bond
NH
S
NH
Q3a
OH


2066
CMe
NMe
Q1u
a bond
Me
a bond
NH
S
NH
Q3b
OH


2067
CMe
NMe
Q1u
a bond
Me
a bond
NH
S
NH
Q3c
OH


2068
CMe
NMe
Q1u
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2069
CMe
NMe
Q1u
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2070
CMe
NMe
Q1u
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2071
CMe
NMe
Q1u
a bond
Me
a bond
NH
O
NH
Q3a
OH


2072
CMe
NMe
Q1u
a bond
Me
a bond
NH
O
NH
Q3b
OH


2073
CMe
NMe
Q1u
a bond
Me
a bond
NH
O
NH
Q3c
OH


2074
CMe
NMe
Q1u
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2075
CMe
NMe
Q1u
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2076
CMe
NMe
Q1u
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2077
CMe
NMe
Q1u
a bond
H
a bond
NH
S
NH
Q3a
OH


2078
CMe
NMe
Q1u
a bond
H
a bond
NH
S
NH
Q3b
OH


2079
CMe
NMe
Q1u
a bond
H
a bond
NH
S
NH
Q3c
OH


2080
CMe
NMe
Q1u
a bond
H
a bond
NH
S
a bond
Q3a
OH


2081
CMe
NMe
Q1u
a bond
H
a bond
NH
S
a bond
Q3b
OH


2082
CMe
NMe
Q1u
a bond
H
a bond
NH
S
a bond
Q3c
OH


2083
CMe
NMe
Q1u
a bond
H
a bond
NH
O
NH
Q3a
OH


2084
CMe
NMe
Q1u
a bond
H
a bond
NH
O
NH
Q3b
OH


2085
CMe
NMe
Q1u
a bond
H
a bond
NH
O
NH
Q3c
OH


2086
CMe
NMe
Q1u
a bond
H
a bond
NH
O
a bond
Q3a
OH


2087
CMe
NMe
Q1u
a bond
H
a bond
NH
O
a bond
Q3b
OH


2088
CMe
NMe
Q1u
a bond
H
a bond
NH
O
a bond
Q3c
OH


2089
CMe
NMe
Q1v
a bond
Me
a bond
NH
S
NH
Q3a
OH


2090
CMe
NMe
Q1v
a bond
Me
a bond
NH
S
NH
Q3b
OH


2091
CMe
NMe
Q1v
a bond
Me
a bond
NH
S
NH
Q3c
OH


2092
CMe
NMe
Q1v
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2093
CMe
NMe
Q1v
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2094
CMe
NMe
Q1v
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2095
CMe
NMe
Q1v
a bond
Me
a bond
NH
O
NH
Q3a
OH


2096
CMe
NMe
Q1v
a bond
Me
a bond
NH
O
NH
Q3b
OH


2097
CMe
NMe
Q1v
a bond
Me
a bond
NH
O
NH
Q3c
OH


2098
CMe
NMe
Q1v
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2099
CMe
NMe
Q1v
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2100
CMe
NMe
Q1v
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2101
CMe
NMe
Q1v
a bond
H
a bond
NH
S
NH
Q3a
OH


2102
CMe
NMe
Q1v
a bond
H
a bond
NH
S
NH
Q3b
OH


2103
CMe
NMe
Q1v
a bond
H
a bond
NH
S
NH
Q3c
OH


2104
CMe
NMe
Q1v
a bond
H
a bond
NH
S
a bond
Q3a
OH


2105
CMe
NMe
Q1v
a bond
H
a bond
NH
S
a bond
Q3b
OH


2106
CMe
NMe
Q1v
a bond
H
a bond
NH
S
a bond
Q3c
OH


2107
CMe
NMe
Q1v
a bond
H
a bond
NH
O
NH
Q3a
OH


2108
CMe
NMe
Q1v
a bond
H
a bond
NH
O
NH
Q3b
OH


2109
CMe
NMe
Q1v
a bond
H
a bond
NH
O
NH
Q3c
OH


2110
CMe
NMe
Q1v
a bond
H
a bond
NH
O
a bond
Q3a
OH


2111
CMe
NMe
Q1v
a bond
H
a bond
NH
O
a bond
Q3b
OH


2112
CMe
NMe
Q1v
a bond
H
a bond
NH
O
a bond
Q3c
OH


2113
CMe
NMe
Q1w
a bond
Me
a bond
NH
S
NH
Q3a
OH


2114
CMe
NMe
Q1w
a bond
Me
a bond
NH
S
NH
Q3b
OH


2115
CMe
NMe
Q1w
a bond
Me
a bond
NH
S
NH
Q3c
OH


2116
CMe
NMe
Q1w
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2117
CMe
NMe
Q1w
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2118
CMe
NMe
Q1w
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2119
CMe
NMe
Q1w
a bond
Me
a bond
NH
O
NH
Q3a
OH


2120
CMe
NMe
Q1w
a bond
Me
a bond
NH
O
NH
Q3b
OH


2121
CMe
NMe
Q1w
a bond
Me
a bond
NH
O
NH
Q3c
OH


2122
CMe
NMe
Q1w
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2123
CMe
NMe
Q1w
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2124
CMe
NMe
Q1w
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2125
CMe
NMe
Q1w
a bond
H
a bond
NH
S
NH
Q3a
OH


2126
CMe
NMe
Q1w
a bond
H
a bond
NH
S
NH
Q3b
OH


2127
CMe
NMe
Q1w
a bond
H
a bond
NH
S
NH
Q3c
OH


2128
CMe
NMe
Q1w
a bond
H
a bond
NH
S
a bond
Q3a
OH


2129
CMe
NMe
Q1w
a bond
H
a bond
NH
S
a bond
Q3b
OH


2130
CMe
NMe
Q1w
a bond
H
a bond
NH
S
a bond
Q3c
OH


2131
CMe
NMe
Q1w
a bond
H
a bond
NH
O
NH
Q3a
OH


2132
CMe
NMe
Q1w
a bond
H
a bond
NH
O
NH
Q3b
OH


2133
CMe
NMe
Q1w
a bond
H
a bond
NH
O
NH
Q3c
OH


2134
CMe
NMe
Q1w
a bond
H
a bond
NH
O
a bond
Q3a
OH


2135
CMe
NMe
Q1w
a bond
H
a bond
NH
O
a bond
Q3b
OH


2136
CMe
NMe
Q1w
a bond
H
a bond
NH
O
a bond
Q3c
OH


2137
CMe
NMe
Q1x
a bond
Me
a bond
NH
S
NH
Q3a
OH


2138
CMe
NMe
Q1x
a bond
Me
a bond
NH
S
NH
Q3b
OH


2139
CMe
NMe
Q1x
a bond
Me
a bond
NH
S
NH
Q3c
OH


2140
CMe
NMe
Q1x
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2141
CMe
NMe
Q1x
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2142
CMe
NMe
Q1x
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2143
CMe
NMe
Q1x
a bond
Me
a bond
NH
O
NH
Q3a
OH


2144
CMe
NMe
Q1x
a bond
Me
a bond
NH
O
NH
Q3b
OH


2145
CMe
NMe
Q1x
a bond
Me
a bond
NH
O
NH
Q3c
OH


2146
CMe
NMe
Q1x
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2147
CMe
NMe
Q1x
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2148
CMe
NMe
Q1x
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2149
CMe
NMe
Q1x
a bond
H
a bond
NH
S
NH
Q3a
OH


2150
CMe
NMe
Q1x
a bond
H
a bond
NH
S
NH
Q3b
OH


2151
CMe
NMe
Q1x
a bond
H
a bond
NH
S
NH
Q3c
OH


2152
CMe
NMe
Q1x
a bond
H
a bond
NH
S
a bond
Q3a
OH


2153
CMe
NMe
Q1x
a bond
H
a bond
NH
S
a bond
Q3b
OH


2154
CMe
NMe
Q1x
a bond
H
a bond
NH
S
a bond
Q3c
OH


2155
CMe
NMe
Q1x
a bond
H
a bond
NH
O
NH
Q3a
OH


2156
CMe
NMe
Q1x
a bond
H
a bond
NH
O
NH
Q3b
OH


2157
CMe
NMe
Q1x
a bond
H
a bond
NH
O
NH
Q3c
OH


2158
CMe
NMe
Q1x
a bond
H
a bond
NH
O
a bond
Q3a
OH


2159
CMe
NMe
Q1x
a bond
H
a bond
NH
O
a bond
Q3b
OH


2160
CMe
NMe
Q1x
a bond
H
a bond
NH
O
a bond
Q3c
OH


2161
CMe
NEt
Q1o
a bond
Me
a bond
NH
S
NH
Q3a
OH


2162
CMe
NEt
Q1o
a bond
Me
a bond
NH
S
NH
Q3b
OH


2163
CMe
NEt
Q1o
a bond
Me
a bond
NH
S
NH
Q3c
OH


2164
CMe
NEt
Q1o
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2165
CMe
NEt
Q1o
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2166
CMe
NEt
Q1o
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2167
CMe
NEt
Q1o
a bond
Me
a bond
NH
O
NH
Q3a
OH


2168
CMe
NEt
Q1o
a bond
Me
a bond
NH
O
NH
Q3b
OH


2169
CMe
NEt
Q1o
a bond
Me
a bond
NH
O
NH
Q3c
OH


2170
CMe
NEt
Q1o
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2171
CMe
NEt
Q1o
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2172
CMe
NEt
Q1o
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2173
CMe
NEt
Q1o
a bond
H
a bond
NH
S
NH
Q3a
OH


2174
CMe
NEt
Q1o
a bond
H
a bond
NH
S
NH
Q3b
OH


2175
CMe
NEt
Q1o
a bond
H
a bond
NH
S
NH
Q3c
OH


2176
CMe
NEt
Q1o
a bond
H
a bond
NH
S
a bond
Q3a
OH


2177
CMe
NEt
Q1o
a bond
H
a bond
NH
S
a bond
Q3b
OH


2178
CMe
NEt
Q1o
a bond
H
a bond
NH
S
a bond
Q3c
OH


2179
CMe
NEt
Q1o
a bond
H
a bond
NH
O
NH
Q3a
OH


2180
CMe
NEt
Q1o
a bond
H
a bond
NH
O
NH
Q3b
OH


2181
CMe
NEt
Q1o
a bond
H
a bond
NH
O
NH
Q3c
OH


2182
CMe
NEt
Q1o
a bond
H
a bond
NH
O
a bond
Q3a
OH


2183
CMe
NEt
Q1o
a bond
H
a bond
NH
O
a bond
Q3b
OH


2184
CMe
NEt
Q1o
a bond
H
a bond
NH
O
a bond
Q3c
OH


2185
CMe
NEt
Q1p
a bond
Me
a bond
NH
S
NH
Q3a
OH


2186
CMe
NEt
Q1p
a bond
Me
a bond
NH
S
NH
Q3b
OH


2187
CMe
NEt
Q1p
a bond
Me
a bond
NH
S
NH
Q3c
OH


2188
CMe
NEt
Q1p
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2189
CMe
NEt
Q1p
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2190
CMe
NEt
Q1p
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2191
CMe
NEt
Q1p
a bond
Me
a bond
NH
O
NH
Q3a
OH


2192
CMe
NEt
Q1p
a bond
Me
a bond
NH
O
NH
Q3b
OH


2193
CMe
NEt
Q1p
a bond
Me
a bond
NH
O
NH
Q3c
OH


2194
CMe
NEt
Q1p
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2195
CMe
NEt
Q1p
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2196
CMe
NEt
Q1p
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2197
CMe
NEt
Q1p
a bond
H
a bond
NH
S
NH
Q3a
OH


2198
CMe
NEt
Q1p
a bond
H
a bond
NH
S
NH
Q3b
OH


2199
CMe
NEt
Q1p
a bond
H
a bond
NH
S
NH
Q3c
OH


2200
CMe
NEt
Q1p
a bond
H
a bond
NH
S
a bond
Q3a
OH


2201
CMe
NEt
Q1p
a bond
H
a bond
NH
S
a bond
Q3b
OH


2202
CMe
NEt
Q1p
a bond
H
a bond
NH
S
a bond
Q3c
OH


2203
CMe
NEt
Q1p
a bond
H
a bond
NH
O
NH
Q3a
OH


2204
CMe
NEt
Q1p
a bond
H
a bond
NH
O
NH
Q3b
OH


2205
CMe
NEt
Q1p
a bond
H
a bond
NH
O
NH
Q3c
OH


2206
CMe
NEt
Q1p
a bond
H
a bond
NH
O
a bond
Q3a
OH


2207
CMe
NEt
Q1p
a bond
H
a bond
NH
O
a bond
Q3b
OH


2208
CMe
NEt
Q1p
a bond
H
a bond
NH
O
a bond
Q3c
OH


2209
CMe
NEt
Q1q
a bond
Me
a bond
NH
S
NH
Q3a
OH


2210
CMe
NEt
Q1q
a bond
Me
a bond
NH
S
NH
Q3b
OH


2211
CMe
NEt
Q1q
a bond
Me
a bond
NH
S
NH
Q3c
OH


2212
CMe
NEt
Q1q
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2213
CMe
NEt
Q1q
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2214
CMe
NEt
Q1q
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2215
CMe
NEt
Q1q
a bond
Me
a bond
NH
O
NH
Q3a
OH


2216
CMe
NEt
Q1q
a bond
Me
a bond
NH
O
NH
Q3b
OH


2217
CMe
NEt
Q1q
a bond
Me
a bond
NH
O
NH
Q3c
OH


2218
CMe
NEt
Q1q
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2219
CMe
NEt
Q1q
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2220
CMe
NEt
Q1q
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2221
CMe
NEt
Q1q
a bond
H
a bond
NH
S
NH
Q3a
OH


2222
CMe
NEt
Q1q
a bond
H
a bond
NH
S
NH
Q3b
OH


2223
CMe
NEt
Q1q
a bond
H
a bond
NH
S
NH
Q3c
OH


2224
CMe
NEt
Q1q
a bond
H
a bond
NH
S
a bond
Q3a
OH


2225
CMe
NEt
Q1q
a bond
H
a bond
NH
S
a bond
Q3b
OH


2226
CMe
NEt
Q1q
a bond
H
a bond
NH
S
a bond
Q3c
OH


2227
CMe
NEt
Q1q
a bond
H
a bond
NH
O
NH
Q3a
OH


2228
CMe
NEt
Q1q
a bond
H
a bond
NH
O
NH
Q3b
OH


2229
CMe
NEt
Q1q
a bond
H
a bond
NH
O
NH
Q3c
OH


2230
CMe
NEt
Q1q
a bond
H
a bond
NH
O
a bond
Q3a
OH


2231
CMe
NEt
Q1q
a bond
H
a bond
NH
O
a bond
Q3b
OH


2232
CMe
NEt
Q1q
a bond
H
a bond
NH
O
a bond
Q3c
OH


2233
CMe
NEt
Q1r
a bond
Me
a bond
NH
S
NH
Q3a
OH


2234
CMe
NEt
Q1r
a bond
Me
a bond
NH
S
NH
Q3b
OH


2235
CMe
NEt
Q1r
a bond
Me
a bond
NH
S
NH
Q3c
OH


2236
CMe
NEt
Q1r
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2237
CMe
NEt
Q1r
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2238
CMe
NEt
Q1r
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2239
CMe
NEt
Q1r
a bond
Me
a bond
NH
O
NH
Q3a
OH


2240
CMe
NEt
Q1r
a bond
Me
a bond
NH
O
NH
Q3b
OH


2241
CMe
NEt
Q1r
a bond
Me
a bond
NH
O
NH
Q3c
OH


2242
CMe
NEt
Q1r
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2243
CMe
NEt
Q1r
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2244
CMe
NEt
Q1r
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2245
CMe
NEt
Q1r
a bond
H
a bond
NH
S
NH
Q3a
OH


2246
CMe
NEt
Q1r
a bond
H
a bond
NH
S
NH
Q3b
OH


2247
CMe
NEt
Q1r
a bond
H
a bond
NH
S
NH
Q3c
OH


2248
CMe
NEt
Q1r
a bond
H
a bond
NH
S
a bond
Q3a
OH


2249
CMe
NEt
Q1r
a bond
H
a bond
NH
S
a bond
Q3b
OH


2250
CMe
NEt
Q1r
a bond
H
a bond
NH
S
a bond
Q3c
OH


2251
CMe
NEt
Q1r
a bond
H
a bond
NH
O
NH
Q3a
OH


2252
CMe
NEt
Q1r
a bond
H
a bond
NH
O
NH
Q3b
OH


2253
CMe
NEt
Q1r
a bond
H
a bond
NH
O
NH
Q3c
OH


2254
CMe
NEt
Q1r
a bond
H
a bond
NH
O
a bond
Q3a
OH


2255
CMe
NEt
Q1r
a bond
H
a bond
NH
O
a bond
Q3b
OH


2256
CMe
NEt
Q1r
a bond
H
a bond
NH
O
a bond
Q3c
OH


2257
CMe
NEt
Q1s
a bond
Me
a bond
NH
S
NH
Q3a
OH


2258
CMe
NEt
Q1s
a bond
Me
a bond
NH
S
NH
Q3b
OH


2259
CMe
NEt
Q1s
a bond
Me
a bond
NH
S
NH
Q3c
OH


2260
CMe
NEt
Q1s
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2261
CMe
NEt
Q1s
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2262
CMe
NEt
Q1s
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2263
CMe
NEt
Q1s
a bond
Me
a bond
NH
O
NH
Q3a
OH


2264
CMe
NEt
Q1s
a bond
Me
a bond
NH
O
NH
Q3b
OH


2265
CMe
NEt
Q1s
a bond
Me
a bond
NH
O
NH
Q3c
OH


2266
CMe
NEt
Q1s
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2267
CMe
NEt
Q1s
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2268
CMe
NEt
Q1s
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2269
CMe
NEt
Q1s
a bond
H
a bond
NH
S
NH
Q3a
OH


2270
CMe
NEt
Q1s
a bond
H
a bond
NH
S
NH
Q3b
OH


2271
CMe
NEt
Q1s
a bond
H
a bond
NH
S
NH
Q3c
OH


2272
CMe
NEt
Q1s
a bond
H
a bond
NH
S
a bond
Q3a
OH


2273
CMe
NEt
Q1s
a bond
H
a bond
NH
S
a bond
Q3b
OH


2274
CMe
NEt
Q1s
a bond
H
a bond
NH
S
a bond
Q3c
OH


2275
CMe
NEt
Q1s
a bond
H
a bond
NH
O
NH
Q3a
OH


2276
CMe
NEt
Q1s
a bond
H
a bond
NH
O
NH
Q3b
OH


2277
CMe
NEt
Q1s
a bond
H
a bond
NH
O
NH
Q3c
OH


2278
CMe
NEt
Q1s
a bond
H
a bond
NH
O
a bond
Q3a
OH


2279
CMe
NEt
Q1s
a bond
H
a bond
NH
O
a bond
Q3b
OH


2280
CMe
NEt
Q1s
a bond
H
a bond
NH
O
a bond
Q3c
OH


2281
CMe
NEt
Q1t
a bond
Me
a bond
NH
S
NH
Q3a
OH


2282
CMe
NEt
Q1t
a bond
Me
a bond
NH
S
NH
Q3b
OH


2283
CMe
NEt
Q1t
a bond
Me
a bond
NH
S
NH
Q3c
OH


2284
CMe
NEt
Q1t
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2285
CMe
NEt
Q1t
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2286
CMe
NEt
Q1t
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2287
CMe
NEt
Q1t
a bond
Me
a bond
NH
O
NH
Q3a
OH


2288
CMe
NEt
Q1t
a bond
Me
a bond
NH
O
NH
Q3b
OH


2289
CMe
NEt
Q1t
a bond
Me
a bond
NH
O
NH
Q3c
OH


2290
CMe
NEt
Q1t
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2291
CMe
NEt
Q1t
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2292
CMe
NEt
Q1t
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2293
CMe
NEt
Q1t
a bond
H
a bond
NH
S
NH
Q3a
OH


2294
CMe
NEt
Q1t
a bond
H
a bond
NH
S
NH
Q3b
OH


2295
CMe
NEt
Q1t
a bond
H
a bond
NH
S
NH
Q3c
OH


2296
CMe
NEt
Q1t
a bond
H
a bond
NH
S
a bond
Q3a
OH


2297
CMe
NEt
Q1t
a bond
H
a bond
NH
S
a bond
Q3b
OH


2298
CMe
NEt
Q1t
a bond
H
a bond
NH
S
a bond
Q3c
OH


2299
CMe
NEt
Q1t
a bond
H
a bond
NH
O
NH
Q3a
OH


2300
CMe
NEt
Q1t
a bond
H
a bond
NH
O
NH
Q3b
OH


2301
CMe
NEt
Q1t
a bond
H
a bond
NH
O
NH
Q3c
OH


2302
CMe
NEt
Q1t
a bond
H
a bond
NH
O
a bond
Q3a
OH


2303
CMe
NEt
Q1t
a bond
H
a bond
NH
O
a bond
Q3b
OH


2304
CMe
NEt
Q1t
a bond
H
a bond
NH
O
a bond
Q3c
OH


2305
CMe
NEt
Q1u
a bond
Me
a bond
NH
S
NH
Q3a
OH


2306
CMe
NEt
Q1u
a bond
Me
a bond
NH
S
NH
Q3b
OH


2307
CMe
NEt
Q1u
a bond
Me
a bond
NH
S
NH
Q3c
OH


2308
CMe
NEt
Q1u
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2309
CMe
NEt
Q1u
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2310
CMe
NEt
Q1u
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2311
CMe
NEt
Q1u
a bond
Me
a bond
NH
O
NH
Q3a
OH


2312
CMe
NEt
Q1u
a bond
Me
a bond
NH
O
NH
Q3b
OH


2313
CMe
NEt
Q1u
a bond
Me
a bond
NH
O
NH
Q3c
OH


2314
CMe
NEt
Q1u
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2315
CMe
NEt
Q1u
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2316
CMe
NEt
Q1u
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2317
CMe
NEt
Q1u
a bond
H
a bond
NH
S
NH
Q3a
OH


2318
CMe
NEt
Q1u
a bond
H
a bond
NH
S
NH
Q3b
OH


2319
CMe
NEt
Q1u
a bond
H
a bond
NH
S
NH
Q3c
OH


2320
CMe
NEt
Q1u
a bond
H
a bond
NH
S
a bond
Q3a
OH


2321
CMe
NEt
Q1u
a bond
H
a bond
NH
S
a bond
Q3b
OH


2322
CMe
NEt
Q1u
a bond
H
a bond
NH
S
a bond
Q3c
OH


2323
CMe
NEt
Q1u
a bond
H
a bond
NH
O
NH
Q3a
OH


2324
CMe
NEt
Q1u
a bond
H
a bond
NH
O
NH
Q3b
OH


2325
CMe
NEt
Q1u
a bond
H
a bond
NH
O
NH
Q3c
OH


2326
CMe
NEt
Q1u
a bond
H
a bond
NH
O
a bond
Q3a
OH


2327
CMe
NEt
Q1u
a bond
H
a bond
NH
O
a bond
Q3b
OH


2328
CMe
NEt
Q1u
a bond
H
a bond
NH
O
a bond
Q3c
OH


2329
CMe
NEt
Q1v
a bond
Me
a bond
NH
S
NH
Q3a
OH


2330
CMe
NEt
Q1v
a bond
Me
a bond
NH
S
NH
Q3b
OH


2331
CMe
NEt
Q1v
a bond
Me
a bond
NH
S
NH
Q3c
OH


2332
CMe
NEt
Q1v
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2333
CMe
NEt
Q1v
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2334
CMe
NEt
Q1v
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2335
CMe
NEt
Q1v
a bond
Me
a bond
NH
O
NH
Q3a
OH


2336
CMe
NEt
Q1v
a bond
Me
a bond
NH
O
NH
Q3b
OH


2337
CMe
NEt
Q1v
a bond
Me
a bond
NH
O
NH
Q3c
OH


2338
CMe
NEt
Q1v
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2339
CMe
NEt
Q1v
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2340
CMe
NEt
Q1v
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2341
CMe
NEt
Q1v
a bond
H
a bond
NH
S
NH
Q3a
OH


2342
CMe
NEt
Q1v
a bond
H
a bond
NH
S
NH
Q3b
OH


2343
CMe
NEt
Q1v
a bond
H
a bond
NH
S
NH
Q3c
OH


2344
CMe
NEt
Q1v
a bond
H
a bond
NH
S
a bond
Q3a
OH


2345
CMe
NEt
Q1v
a bond
H
a bond
NH
S
a bond
Q3b
OH


2346
CMe
NEt
Q1v
a bond
H
a bond
NH
S
a bond
Q3c
OH


2347
CMe
NEt
Q1v
a bond
H
a bond
NH
O
NH
Q3a
OH


2348
CMe
NEt
Q1v
a bond
H
a bond
NH
O
NH
Q3b
OH


2349
CMe
NEt
Q1v
a bond
H
a bond
NH
O
NH
Q3c
OH


2350
CMe
NEt
Q1v
a bond
H
a bond
NH
O
a bond
Q3a
OH


2351
CMe
NEt
Q1v
a bond
H
a bond
NH
O
a bond
Q3b
OH


2352
CMe
NEt
Q1v
a bond
H
a bond
NH
O
a bond
Q3c
OH


2353
CMe
NEt
Q1w
a bond
Me
a bond
NH
S
NH
Q3a
OH


2354
CMe
NEt
Q1w
a bond
Me
a bond
NH
S
NH
Q3b
OH


2355
CMe
NEt
Q1w
a bond
Me
a bond
NH
S
NH
Q3c
OH


2356
CMe
NEt
Q1w
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2357
CMe
NEt
Q1w
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2358
CMe
NEt
Q1w
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2359
CMe
NEt
Q1w
a bond
Me
a bond
NH
O
NH
Q3a
OH


2360
CMe
NEt
Q1w
a bond
Me
a bond
NH
O
NH
Q3b
OH


2361
CMe
NEt
Q1w
a bond
Me
a bond
NH
O
NH
Q3c
OH


2362
CMe
NEt
Q1w
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2363
CMe
NEt
Q1w
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2364
CMe
NEt
Q1w
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2365
CMe
NEt
Q1w
a bond
H
a bond
NH
S
NH
Q3a
OH


2366
CMe
NEt
Q1w
a bond
H
a bond
NH
S
NH
Q3b
OH


2367
CMe
NEt
Q1w
a bond
H
a bond
NH
S
NH
Q3c
OH


2368
CMe
NEt
Q1w
a bond
H
a bond
NH
S
a bond
Q3a
OH


2369
CMe
NEt
Q1w
a bond
H
a bond
NH
S
a bond
Q3b
OH


2370
CMe
NEt
Q1w
a bond
H
a bond
NH
S
a bond
Q3c
OH


2371
CMe
NEt
Q1w
a bond
H
a bond
NH
O
NH
Q3a
OH


2372
CMe
NEt
Q1w
a bond
H
a bond
NH
O
NH
Q3b
OH


2373
CMe
NEt
Q1w
a bond
H
a bond
NH
O
NH
Q3c
OH


2374
CMe
NEt
Q1w
a bond
H
a bond
NH
O
a bond
Q3a
OH


2375
CMe
NEt
Q1w
a bond
H
a bond
NH
O
a bond
Q3b
OH


2376
CMe
NEt
Q1w
a bond
H
a bond
NH
O
a bond
Q3c
OH


2377
CMe
NEt
Q1x
a bond
Me
a bond
NH
S
NH
Q3a
OH


2378
CMe
NEt
Q1x
a bond
Me
a bond
NH
S
NH
Q3b
OH


2379
CMe
NEt
Q1x
a bond
Me
a bond
NH
S
NH
Q3c
OH


2380
CMe
NEt
Q1x
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2381
CMe
NEt
Q1x
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2382
CMe
NEt
Q1x
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2383
CMe
NEt
Q1x
a bond
Me
a bond
NH
O
NH
Q3a
OH


2384
CMe
NEt
Q1x
a bond
Me
a bond
NH
O
NH
Q3b
OH


2385
CMe
NEt
Q1x
a bond
Me
a bond
NH
O
NH
Q3c
OH


2386
CMe
NEt
Q1x
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2387
CMe
NEt
Q1x
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2388
CMe
NEt
Q1x
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2389
CMe
NEt
Q1x
a bond
H
a bond
NH
S
NH
Q3a
OH


2390
CMe
NEt
Q1x
a bond
H
a bond
NH
S
NH
Q3b
OH


2391
CMe
NEt
Q1x
a bond
H
a bond
NH
S
NH
Q3c
OH


2392
CMe
NEt
Q1x
a bond
H
a bond
NH
S
a bond
Q3a
OH


2393
CMe
NEt
Q1x
a bond
H
a bond
NH
S
a bond
Q3b
OH


2394
CMe
NEt
Q1x
a bond
H
a bond
NH
S
a bond
Q3c
OH


2395
CMe
NEt
Q1x
a bond
H
a bond
NH
O
NH
Q3a
OH


2396
CMe
NEt
Q1x
a bond
H
a bond
NH
O
NH
Q3b
OH


2397
CMe
NEt
Q1x
a bond
H
a bond
NH
O
NH
Q3c
OH


2398
CMe
NEt
Q1x
a bond
H
a bond
NH
O
a bond
Q3a
OH


2399
CMe
NEt
Q1x
a bond
H
a bond
NH
O
a bond
Q3b
OH


2400
CMe
NEt
Q1x
a bond
H
a bond
NH
O
a bond
Q3c
OH


2401
CMe
S
Q1o
a bond
Me
a bond
NH
S
NH
Q3a
OH


2402
CMe
S
Q1o
a bond
Me
a bond
NH
S
NH
Q3b
OH


2403
CMe
S
Q1o
a bond
Me
a bond
NH
S
NH
Q3c
OH


2404
CMe
S
Q1o
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2405
CMe
S
Q1o
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2406
CMe
S
Q1o
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2407
CMe
S
Q1o
a bond
Me
a bond
NH
O
NH
Q3a
OH


2408
CMe
S
Q1o
a bond
Me
a bond
NH
O
NH
Q3b
OH


2409
CMe
S
Q1o
a bond
Me
a bond
NH
O
NH
Q3c
OH


2410
CMe
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2411
CMe
S
Q1o
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2412
CMe
S
Q1o
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2413
CMe
S
Q1o
a bond
H
a bond
NH
S
NH
Q3a
OH


2414
CMe
S
Q1o
a bond
H
a bond
NH
S
NH
Q3b
OH


2415
CMe
S
Q1o
a bond
H
a bond
NH
S
NH
Q3c
OH


2416
CMe
S
Q1o
a bond
H
a bond
NH
S
a bond
Q3a
OH


2417
CMe
S
Q1o
a bond
H
a bond
NH
S
a bond
Q3b
OH


2418
CMe
S
Q1o
a bond
H
a bond
NH
S
a bond
Q3c
OH


2419
CMe
S
Q1o
a bond
H
a bond
NH
O
NH
Q3a
OH


2420
CMe
S
Q1o
a bond
H
a bond
NH
O
NH
Q3b
OH


2421
CMe
S
Q1o
a bond
H
a bond
NH
O
NH
Q3c
OH


2422
CMe
S
Q1o
a bond
H
a bond
NH
O
a bond
Q3a
OH


2423
CMe
S
Q1o
a bond
H
a bond
NH
O
a bond
Q3b
OH


2424
CMe
S
Q1o
a bond
H
a bond
NH
O
a bond
Q3c
OH


2425
CMe
S
Q1p
a bond
Me
a bond
NH
S
NH
Q3a
OH


2426
CMe
S
Q1p
a bond
Me
a bond
NH
S
NH
Q3b
OH


2427
CMe
S
Q1p
a bond
Me
a bond
NH
S
NH
Q3c
OH


2428
CMe
S
Q1p
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2429
CMe
S
Q1p
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2430
CMe
S
Q1p
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2431
CMe
S
Q1p
a bond
Me
a bond
NH
O
NH
Q3a
OH


2432
CMe
S
Q1p
a bond
Me
a bond
NH
O
NH
Q3b
OH


2433
CMe
S
Q1p
a bond
Me
a bond
NH
O
NH
Q3c
OH


2434
CMe
S
Q1p
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2435
CMe
S
Q1p
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2436
CMe
S
Q1p
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2437
CMe
S
Q1p
a bond
H
a bond
NH
S
NH
Q3a
OH


2438
CMe
S
Q1p
a bond
H
a bond
NH
S
NH
Q3b
OH


2439
CMe
S
Q1p
a bond
H
a bond
NH
S
NH
Q3c
OH


2440
CMe
S
Q1p
a bond
H
a bond
NH
S
a bond
Q3a
OH


2441
CMe
S
Q1p
a bond
H
a bond
NH
S
a bond
Q3b
OH


2442
CMe
S
Q1p
a bond
H
a bond
NH
S
a bond
Q3c
OH


2443
CMe
S
Q1p
a bond
H
a bond
NH
O
NH
Q3a
OH


2444
CMe
S
Q1p
a bond
H
a bond
NH
O
NH
Q3b
OH


2445
CMe
S
Q1p
a bond
H
a bond
NH
O
NH
Q3c
OH


2446
CMe
S
Q1p
a bond
H
a bond
NH
O
a bond
Q3a
OH


2447
CMe
S
Q1p
a bond
H
a bond
NH
O
a bond
Q3b
OH


2448
CMe
S
Q1p
a bond
H
a bond
NH
O
a bond
Q3c
OH


2449
CMe
S
Q1q
a bond
Me
a bond
NH
S
NH
Q3a
OH


2450
CMe
S
Q1q
a bond
Me
a bond
NH
S
NH
Q3b
OH


2451
CMe
S
Q1q
a bond
Me
a bond
NH
S
NH
Q3c
OH


2452
CMe
S
Q1q
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2453
CMe
S
Q1q
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2454
CMe
S
Q1q
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2455
CMe
S
Q1q
a bond
Me
a bond
NH
O
NH
Q3a
OH


2456
CMe
S
Q1q
a bond
Me
a bond
NH
O
NH
Q3b
OH


2457
CMe
S
Q1q
a bond
Me
a bond
NH
O
NH
Q3c
OH


2458
CMe
S
Q1q
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2459
CMe
S
Q1q
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2460
CMe
S
Q1q
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2461
CMe
S
Q1q
a bond
H
a bond
NH
S
NH
Q3a
OH


2462
CMe
S
Q1q
a bond
H
a bond
NH
S
NH
Q3b
OH


2463
CMe
S
Q1q
a bond
H
a bond
NH
S
NH
Q3c
OH


2464
CMe
S
Q1q
a bond
H
a bond
NH
S
a bond
Q3a
OH


2465
CMe
S
Q1q
a bond
H
a bond
NH
S
a bond
Q3b
OH


2466
CMe
S
Q1q
a bond
H
a bond
NH
S
a bond
Q3c
OH


2467
CMe
S
Q1q
a bond
H
a bond
NH
O
NH
Q3a
OH


2468
CMe
S
Q1q
a bond
H
a bond
NH
O
NH
Q3b
OH


2469
CMe
S
Q1q
a bond
H
a bond
NH
O
NH
Q3c
OH


2470
CMe
S
Q1q
a bond
H
a bond
NH
O
a bond
Q3a
OH


2471
CMe
S
Q1q
a bond
H
a bond
NH
O
a bond
Q3b
OH


2472
CMe
S
Q1q
a bond
H
a bond
NH
O
a bond
Q3c
OH


2473
CMe
S
Q1r
a bond
Me
a bond
NH
S
NH
Q3a
OH


2474
CMe
S
Q1r
a bond
Me
a bond
NH
S
NH
Q3b
OH


2475
CMe
S
Q1r
a bond
Me
a bond
NH
S
NH
Q3c
OH


2476
CMe
S
Q1r
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2477
CMe
S
Q1r
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2478
CMe
S
Q1r
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2479
CMe
S
Q1r
a bond
Me
a bond
NH
O
NH
Q3a
OH


2480
CMe
S
Q1r
a bond
Me
a bond
NH
O
NH
Q3b
OH


2481
CMe
S
Q1r
a bond
Me
a bond
NH
O
NH
Q3c
OH


2482
CMe
S
Q1r
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2483
CMe
S
Q1r
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2484
CMe
S
Q1r
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2485
CMe
S
Q1r
a bond
H
a bond
NH
S
NH
Q3a
OH


2486
CMe
S
Q1r
a bond
H
a bond
NH
S
NH
Q3b
OH


2487
CMe
S
Q1r
a bond
H
a bond
NH
S
NH
Q3c
OH


2488
CMe
S
Q1r
a bond
H
a bond
NH
S
a bond
Q3a
OH


2489
CMe
S
Q1r
a bond
H
a bond
NH
S
a bond
Q3b
OH


2490
CMe
S
Q1r
a bond
H
a bond
NH
S
a bond
Q3c
OH


2491
CMe
S
Q1r
a bond
H
a bond
NH
O
NH
Q3a
OH


2492
CMe
S
Q1r
a bond
H
a bond
NH
O
NH
Q3b
OH


2493
CMe
S
Q1r
a bond
H
a bond
NH
O
NH
Q3c
OH


2494
CMe
S
Q1r
a bond
H
a bond
NH
O
a bond
Q3a
OH


2495
CMe
S
Q1r
a bond
H
a bond
NH
O
a bond
Q3b
OH


2496
CMe
S
Q1r
a bond
H
a bond
NH
O
a bond
Q3c
OH


2497
CMe
S
Q1s
a bond
Me
a bond
NH
S
NH
Q3a
OH


2498
CMe
S
Q1s
a bond
Me
a bond
NH
S
NH
Q3b
OH


2499
CMe
S
Q1s
a bond
Me
a bond
NH
S
NH
Q3c
OH


2500
CMe
S
Q1s
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2501
CMe
S
Q1s
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2502
CMe
S
Q1s
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2503
CMe
S
Q1s
a bond
Me
a bond
NH
O
NH
Q3a
OH


2504
CMe
S
Q1s
a bond
Me
a bond
NH
O
NH
Q3b
OH


2505
CMe
S
Q1s
a bond
Me
a bond
NH
O
NH
Q3c
OH


2506
CMe
S
Q1s
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2507
CMe
S
Q1s
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2508
CMe
S
Q1s
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2509
CMe
S
Q1s
a bond
H
a bond
NH
S
NH
Q3a
OH


2510
CMe
S
Q1s
a bond
H
a bond
NH
S
NH
Q3b
OH


2511
CMe
S
Q1s
a bond
H
a bond
NH
S
NH
Q3c
OH


2512
CMe
S
Q1s
a bond
H
a bond
NH
S
a bond
Q3a
OH


2513
CMe
S
Q1s
a bond
H
a bond
NH
S
a bond
Q3b
OH


2514
CMe
S
Q1s
a bond
H
a bond
NH
S
a bond
Q3c
OH


2515
CMe
S
Q1s
a bond
H
a bond
NH
O
NH
Q3a
OH


2516
CMe
S
Q1s
a bond
H
a bond
NH
O
NH
Q3b
OH


2517
CMe
S
Q1s
a bond
H
a bond
NH
O
NH
Q3c
OH


2518
CMe
S
Q1s
a bond
H
a bond
NH
O
a bond
Q3a
OH


2519
CMe
S
Q1s
a bond
H
a bond
NH
O
a bond
Q3b
OH


2520
CMe
S
Q1s
a bond
H
a bond
NH
O
a bond
Q3c
OH


2521
CMe
S
Q1t
a bond
Me
a bond
NH
S
NH
Q3a
OH


2522
CMe
S
Q1t
a bond
Me
a bond
NH
S
NH
Q3b
OH


2523
CMe
S
Q1t
a bond
Me
a bond
NH
S
NH
Q3c
OH


2524
CMe
S
Q1t
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2525
CMe
S
Q1t
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2526
CMe
S
Q1t
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2527
CMe
S
Q1t
a bond
Me
a bond
NH
O
NH
Q3a
OH


2528
CMe
S
Q1t
a bond
Me
a bond
NH
O
NH
Q3b
OH


2529
CMe
S
Q1t
a bond
Me
a bond
NH
O
NH
Q3c
OH


2530
CMe
S
Q1t
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2531
CMe
S
Q1t
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2532
CMe
S
Q1t
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2533
CMe
S
Q1t
a bond
H
a bond
NH
S
NH
Q3a
OH


2534
CMe
S
Q1t
a bond
H
a bond
NH
S
NH
Q3b
OH


2535
CMe
S
Q1t
a bond
H
a bond
NH
S
NH
Q3c
OH


2536
CMe
S
Q1t
a bond
H
a bond
NH
S
a bond
Q3a
OH


2537
CMe
S
Q1t
a bond
H
a bond
NH
S
a bond
Q3b
OH


2538
CMe
S
Q1t
a bond
H
a bond
NH
S
a bond
Q3c
OH


2539
CMe
S
Q1t
a bond
H
a bond
NH
O
NH
Q3a
OH


2540
CMe
S
Q1t
a bond
H
a bond
NH
O
NH
Q3b
OH


2541
CMe
S
Q1t
a bond
H
a bond
NH
O
NH
Q3c
OH


2542
CMe
S
Q1t
a bond
H
a bond
NH
O
a bond
Q3a
OH


2543
CMe
S
Q1t
a bond
H
a bond
NH
O
a bond
Q3b
OH


2544
CMe
S
Q1t
a bond
H
a bond
NH
O
a bond
Q3c
OH


2545
CMe
S
Q1u
a bond
Me
a bond
NH
S
NH
Q3a
OH


2546
CMe
S
Q1u
a bond
Me
a bond
NH
S
NH
Q3b
OH


2547
CMe
S
Q1u
a bond
Me
a bond
NH
S
NH
Q3c
OH


2548
CMe
S
Q1u
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2549
CMe
S
Q1u
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2550
CMe
S
Q1u
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2551
CMe
S
Q1u
a bond
Me
a bond
NH
O
NH
Q3a
OH


2552
CMe
S
Q1u
a bond
Me
a bond
NH
O
NH
Q3b
OH


2553
CMe
S
Q1u
a bond
Me
a bond
NH
O
NH
Q3c
OH


2554
CMe
S
Q1u
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2555
CMe
S
Q1u
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2556
CMe
S
Q1u
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2557
CMe
S
Q1u
a bond
H
a bond
NH
S
NH
Q3a
OH


2558
CMe
S
Q1u
a bond
H
a bond
NH
S
NH
Q3b
OH


2559
CMe
S
Q1u
a bond
H
a bond
NH
S
NH
Q3c
OH


2560
CMe
S
Q1u
a bond
H
a bond
NH
S
a bond
Q3a
OH


2561
CMe
S
Q1u
a bond
H
a bond
NH
S
a bond
Q3b
OH


2562
CMe
S
Q1u
a bond
H
a bond
NH
S
a bond
Q3c
OH


2563
CMe
S
Q1u
a bond
H
a bond
NH
O
NH
Q3a
OH


2564
CMe
S
Q1u
a bond
H
a bond
NH
O
NH
Q3b
OH


2565
CMe
S
Q1u
a bond
H
a bond
NH
O
NH
Q3c
OH


2566
CMe
S
Q1u
a bond
H
a bond
NH
O
a bond
Q3a
OH


2567
CMe
S
Q1u
a bond
H
a bond
NH
O
a bond
Q3b
OH


2568
CMe
S
Q1u
a bond
H
a bond
NH
O
a bond
Q3c
OH


2569
CMe
S
Q1v
a bond
Me
a bond
NH
S
NH
Q3a
OH


2570
CMe
S
Q1v
a bond
Me
a bond
NH
S
NH
Q3b
OH


2571
CMe
S
Q1v
a bond
Me
a bond
NH
S
NH
Q3c
OH


2572
CMe
S
Q1v
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2573
CMe
S
Q1v
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2574
CMe
S
Q1v
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2575
CMe
S
Q1v
a bond
Me
a bond
NH
O
NH
Q3a
OH


2576
CMe
S
Q1v
a bond
Me
a bond
NH
O
NH
Q3b
OH


2577
CMe
S
Q1v
a bond
Me
a bond
NH
O
NH
Q3c
OH


2578
CMe
S
Q1v
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2579
CMe
S
Q1v
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2580
CMe
S
Q1v
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2581
CMe
S
Q1v
a bond
H
a bond
NH
S
NH
Q3a
OH


2582
CMe
S
Q1v
a bond
H
a bond
NH
S
NH
Q3b
OH


2583
CMe
S
Q1v
a bond
H
a bond
NH
S
NH
Q3c
OH


2584
CMe
S
Q1v
a bond
H
a bond
NH
S
a bond
Q3a
OH


2585
CMe
S
Q1v
a bond
H
a bond
NH
S
a bond
Q3b
OH


2586
CMe
S
Q1v
a bond
H
a bond
NH
S
a bond
Q3c
OH


2587
CMe
S
Q1v
a bond
H
a bond
NH
O
NH
Q3a
OH


2588
CMe
S
Q1v
a bond
H
a bond
NH
O
NH
Q3b
OH


2589
CMe
S
Q1v
a bond
H
a bond
NH
O
NH
Q3c
OH


2590
CMe
S
Q1v
a bond
H
a bond
NH
O
a bond
Q3a
OH


2591
CMe
S
Q1v
a bond
H
a bond
NH
O
a bond
Q3b
OH


2592
CMe
S
Q1v
a bond
H
a bond
NH
O
a bond
Q3c
OH


2593
CMe
S
Q1w
a bond
Me
a bond
NH
S
NH
Q3a
OH


2594
CMe
S
Q1w
a bond
Me
a bond
NH
S
NH
Q3b
OH


2595
CMe
S
Q1w
a bond
Me
a bond
NH
S
NH
Q3c
OH


2596
CMe
S
Q1w
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2597
CMe
S
Q1w
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2598
CMe
S
Q1w
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2599
CMe
S
Q1w
a bond
Me
a bond
NH
O
NH
Q3a
OH


2600
CMe
S
Q1w
a bond
Me
a bond
NH
O
NH
Q3b
OH


2601
CMe
S
Q1w
a bond
Me
a bond
NH
O
NH
Q3c
OH


2602
CMe
S
Q1w
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2603
CMe
S
Q1w
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2604
CMe
S
Q1w
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2605
CMe
S
Q1w
a bond
H
a bond
NH
S
NH
Q3a
OH


2606
CMe
S
Q1w
a bond
H
a bond
NH
S
NH
Q3b
OH


2607
CMe
S
Q1w
a bond
H
a bond
NH
S
NH
Q3c
OH


2608
CMe
S
Q1w
a bond
H
a bond
NH
S
a bond
Q3a
OH


2609
CMe
S
Q1w
a bond
H
a bond
NH
S
a bond
Q3b
OH


2610
CMe
S
Q1w
a bond
H
a bond
NH
S
a bond
Q3c
OH


2611
CMe
S
Q1w
a bond
H
a bond
NH
O
NH
Q3a
OH


2612
CMe
S
Q1w
a bond
H
a bond
NH
O
NH
Q3b
OH


2613
CMe
S
Q1w
a bond
H
a bond
NH
O
NH
Q3c
OH


2614
CMe
S
Q1w
a bond
H
a bond
NH
O
a bond
Q3a
OH


2615
CMe
S
Q1w
a bond
H
a bond
NH
O
a bond
Q3b
OH


2616
CMe
S
Q1w
a bond
H
a bond
NH
O
a bond
Q3c
OH


2617
CMe
S
Q1x
a bond
Me
a bond
NH
S
NH
Q3a
OH


2618
CMe
S
Q1x
a bond
Me
a bond
NH
S
NH
Q3b
OH


2619
CMe
S
Q1x
a bond
Me
a bond
NH
S
NH
Q3c
OH


2620
CMe
S
Q1x
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2621
CMe
S
Q1x
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2622
CMe
S
Q1x
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2623
CMe
S
Q1x
a bond
Me
a bond
NH
O
NH
Q3a
OH


2624
CMe
S
Q1x
a bond
Me
a bond
NH
O
NH
Q3b
OH


2625
CMe
S
Q1x
a bond
Me
a bond
NH
O
NH
Q3c
OH


2626
CMe
S
Q1x
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2627
CMe
S
Q1x
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2628
CMe
S
Q1x
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2629
CMe
S
Q1x
a bond
H
a bond
NH
S
NH
Q3a
OH


2630
CMe
S
Q1x
a bond
H
a bond
NH
S
NH
Q3b
OH


2631
CMe
S
Q1x
a bond
H
a bond
NH
S
NH
Q3c
OH


2632
CMe
S
Q1x
a bond
H
a bond
NH
S
a bond
Q3a
OH


2633
CMe
S
Q1x
a bond
H
a bond
NH
S
a bond
Q3b
OH


2634
CMe
S
Q1x
a bond
H
a bond
NH
S
a bond
Q3c
OH


2635
CMe
S
Q1x
a bond
H
a bond
NH
O
NH
Q3a
OH


2636
CMe
S
Q1x
a bond
H
a bond
NH
O
NH
Q3b
OH


2637
CMe
S
Q1x
a bond
H
a bond
NH
O
NH
Q3c
OH


2638
CMe
S
Q1x
a bond
H
a bond
NH
O
a bond
Q3a
OH


2639
CMe
S
Q1x
a bond
H
a bond
NH
O
a bond
Q3b
OH


2640
CMe
S
Q1x
a bond
H
a bond
NH
O
a bond
Q3c
OH


2641
CMe
O
Q1o
a bond
Me
a bond
NH
S
NH
Q3a
OH


2642
CMe
O
Q1o
a bond
Me
a bond
NH
S
NH
Q3b
OH


2643
CMe
O
Q1o
a bond
Me
a bond
NH
S
NH
Q3c
OH


2644
CMe
O
Q1o
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2645
CMe
O
Q1o
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2646
CMe
O
Q1o
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2647
CMe
O
Q1o
a bond
Me
a bond
NH
O
NH
Q3a
OH


2648
CMe
O
Q1o
a bond
Me
a bond
NH
O
NH
Q3b
OH


2649
CMe
O
Q1o
a bond
Me
a bond
NH
O
NH
Q3c
OH


2650
CMe
O
Q1o
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2651
CMe
O
Q1o
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2652
CMe
O
Q1o
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2653
CMe
O
Q1o
a bond
H
a bond
NH
S
NH
Q3a
OH


2654
CMe
O
Q1o
a bond
H
a bond
NH
S
NH
Q3b
OH


2655
CMe
O
Q1o
a bond
H
a bond
NH
S
NH
Q3c
OH


2656
CMe
O
Q1o
a bond
H
a bond
NH
S
a bond
Q3a
OH


2657
CMe
O
Q1o
a bond
H
a bond
NH
S
a bond
Q3b
OH


2658
CMe
O
Q1o
a bond
H
a bond
NH
S
a bond
Q3c
OH


2659
CMe
O
Q1o
a bond
H
a bond
NH
O
NH
Q3a
OH


2660
CMe
O
Q1o
a bond
H
a bond
NH
O
NH
Q3b
OH


2661
CMe
O
Q1o
a bond
H
a bond
NH
O
NH
Q3c
OH


2662
CMe
O
Q1o
a bond
H
a bond
NH
O
a bond
Q3a
OH


2663
CMe
O
Q1o
a bond
H
a bond
NH
O
a bond
Q3b
OH


2664
CMe
O
Q1o
a bond
H
a bond
NH
O
a bond
Q3c
OH


2665
CMe
O
Q1p
a bond
Me
a bond
NH
S
NH
Q3a
OH


2666
CMe
O
Q1p
a bond
Me
a bond
NH
S
NH
Q3b
OH


2667
CMe
O
Q1p
a bond
Me
a bond
NH
S
NH
Q3c
OH


2668
CMe
O
Q1p
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2669
CMe
O
Q1p
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2670
CMe
O
Q1p
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2671
CMe
O
Q1p
a bond
Me
a bond
NH
O
NH
Q3a
OH


2672
CMe
O
Q1p
a bond
Me
a bond
NH
O
NH
Q3b
OH


2673
CMe
O
Q1p
a bond
Me
a bond
NH
O
NH
Q3c
OH


2674
CMe
O
Q1p
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2675
CMe
O
Q1p
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2676
CMe
O
Q1p
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2677
CMe
O
Q1p
a bond
H
a bond
NH
S
NH
Q3a
OH


2678
CMe
O
Q1p
a bond
H
a bond
NH
S
NH
Q3b
OH


2679
CMe
O
Q1p
a bond
H
a bond
NH
S
NH
Q3c
OH


2680
CMe
O
Q1p
a bond
H
a bond
NH
S
a bond
Q3a
OH


2681
CMe
O
Q1p
a bond
H
a bond
NH
S
a bond
Q3b
OH


2682
CMe
O
Q1p
a bond
H
a bond
NH
S
a bond
Q3c
OH


2683
CMe
O
Q1p
a bond
H
a bond
NH
O
NH
Q3a
OH


2684
CMe
O
Q1p
a bond
H
a bond
NH
O
NH
Q3b
OH


2685
CMe
O
Q1p
a bond
H
a bond
NH
O
NH
Q3c
OH


2686
CMe
O
Q1p
a bond
H
a bond
NH
O
a bond
Q3a
OH


2687
CMe
O
Q1p
a bond
H
a bond
NH
O
a bond
Q3b
OH


2688
CMe
O
Q1p
a bond
H
a bond
NH
O
a bond
Q3c
OH


2689
CMe
O
Q1q
a bond
Me
a bond
NH
S
NH
Q3a
OH


2690
CMe
O
Q1q
a bond
Me
a bond
NH
S
NH
Q3b
OH


2691
CMe
O
Q1q
a bond
Me
a bond
NH
S
NH
Q3c
OH


2692
CMe
O
Q1q
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2693
CMe
O
Q1q
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2694
CMe
O
Q1q
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2695
CMe
O
Q1q
a bond
Me
a bond
NH
O
NH
Q3a
OH


2696
CMe
O
Q1q
a bond
Me
a bond
NH
O
NH
Q3b
OH


2697
CMe
O
Q1q
a bond
Me
a bond
NH
O
NH
Q3c
OH


2698
CMe
O
Q1q
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2699
CMe
O
Q1q
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2700
CMe
O
Q1q
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2701
CMe
O
Q1q
a bond
H
a bond
NH
S
NH
Q3a
OH


2702
CMe
O
Q1q
a bond
H
a bond
NH
S
NH
Q3b
OH


2703
CMe
O
Q1q
a bond
H
a bond
NH
S
NH
Q3c
OH


2704
CMe
O
Q1q
a bond
H
a bond
NH
S
a bond
Q3a
OH


2705
CMe
O
Q1q
a bond
H
a bond
NH
S
a bond
Q3b
OH


2706
CMe
O
Q1q
a bond
H
a bond
NH
S
a bond
Q3c
OH


2707
CMe
O
Q1q
a bond
H
a bond
NH
O
NH
Q3a
OH


2708
CMe
O
Q1q
a bond
H
a bond
NH
O
NH
Q3b
OH


2709
CMe
O
Q1p
a bond
H
a bond
NH
O
NH
Q3c
OH


2710
CMe
O
Q1q
a bond
H
a bond
NH
O
a bond
Q3a
OH


2711
CMe
O
Q1q
a bond
H
a bond
NH
O
a bond
Q3b
OH


2712
CMe
O
Q1q
a bond
H
a bond
NH
O
a bond
Q3c
OH


2713
CMe
O
Q1r
a bond
Me
a bond
NH
S
NH
Q3a
OH


2714
CMe
O
Q1r
a bond
Me
a bond
NH
S
NH
Q3b
OH


2715
CMe
O
Q1r
a bond
Me
a bond
NH
S
NH
Q3c
OH


2716
CMe
O
Q1r
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2717
CMe
O
Q1r
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2718
CMe
O
Q1r
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2719
CMe
O
Q1r
a bond
Me
a bond
NH
O
NH
Q3a
OH


2720
CMe
O
Q1r
a bond
Me
a bond
NH
O
NH
Q3b
OH


2721
CMe
O
Q1r
a bond
Me
a bond
NH
O
NH
Q3c
OH


2722
CMe
O
Q1r
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2723
CMe
O
Q1r
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2724
CMe
O
Q1r
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2725
CMe
O
Q1r
a bond
H
a bond
NH
S
NH
Q3a
OH


2726
CMe
O
Q1r
a bond
H
a bond
NH
S
NH
Q3b
OH


2727
CMe
O
Q1r
a bond
H
a bond
NH
S
NH
Q3c
OH


2728
CMe
O
Q1r
a bond
H
a bond
NH
S
a bond
Q3a
OH


2729
CMe
O
Q1r
a bond
H
a bond
NH
S
a bond
Q3b
OH


2730
CMe
O
Q1r
a bond
H
a bond
NH
S
a bond
Q3c
OH


2731
CMe
O
Q1r
a bond
H
a bond
NH
O
NH
Q3a
OH


2732
CMe
O
Q1r
a bond
H
a bond
NH
O
NH
Q3b
OH


2733
CMe
O
Q1r
a bond
H
a bond
NH
O
NH
Q3c
OH


2734
CMe
O
Q1r
a bond
H
a bond
NH
O
a bond
Q3a
OH


2735
CMe
O
Q1r
a bond
H
a bond
NH
O
a bond
Q3b
OH


2736
CMe
O
Q1r
a bond
H
a bond
NH
O
a bond
Q3c
OH


2737
CMe
O
Q1s
a bond
Me
a bond
NH
S
NH
Q3a
OH


2738
CMe
O
Q1s
a bond
Me
a bond
NH
S
NH
Q3b
OH


2739
CMe
O
Q1s
a bond
Me
a bond
NH
S
NH
Q3c
OH


2740
CMe
O
Q1s
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2741
CMe
O
Q1s
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2742
CMe
O
Q1s
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2743
CMe
O
Q1s
a bond
Me
a bond
NH
O
NH
Q3a
OH


2744
CMe
O
Q1s
a bond
Me
a bond
NH
O
NH
Q3b
OH


2745
CMe
O
Q1s
a bond
Me
a bond
NH
O
NH
Q3c
OH


2746
CMe
O
Q1s
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2747
CMe
O
Q1s
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2748
CMe
O
Q1s
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2749
CMe
O
Q1s
a bond
H
a bond
NH
S
NH
Q3a
OH


2750
CMe
O
Q1s
a bond
H
a bond
NH
S
NH
Q3b
OH


2751
CMe
O
Q1s
a bond
H
a bond
NH
S
NH
Q3c
OH


2752
CMe
O
Q1s
a bond
H
a bond
NH
S
a bond
Q3a
OH


2753
CMe
O
Q1s
a bond
H
a bond
NH
S
a bond
Q3b
OH


2754
CMe
O
Q1s
a bond
H
a bond
NH
S
a bond
Q3c
OH


2755
CMe
O
Q1s
a bond
H
a bond
NH
O
NH
Q3a
OH


2756
CMe
O
Q1s
a bond
H
a bond
NH
O
NH
Q3b
OH


2757
CMe
O
Q1s
a bond
H
a bond
NH
O
NH
Q3c
OH


2758
CMe
O
Q1s
a bond
H
a bond
NH
O
a bond
Q3a
OH


2759
CMe
O
Q1s
a bond
H
a bond
NH
O
a bond
Q3b
OH


2760
CMe
O
Q1s
a bond
H
a bond
NH
O
a bond
Q3c
OH


2761
CMe
O
Q1t
a bond
Me
a bond
NH
S
NH
Q3a
OH


2762
CMe
O
Q1t
a bond
Me
a bond
NH
S
NH
Q3b
OH


2763
CMe
O
Q1t
a bond
Me
a bond
NH
S
NH
Q3c
OH


2764
CMe
O
Q1t
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2765
CMe
O
Q1t
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2766
CMe
O
Q1t
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2767
CMe
O
Q1t
a bond
Me
a bond
NH
O
NH
Q3a
OH


2768
CMe
O
Q1t
a bond
Me
a bond
NH
O
NH
Q3b
OH


2769
CMe
O
Q1t
a bond
Me
a bond
NH
O
NH
Q3c
OH


2770
CMe
O
Q1t
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2771
CMe
O
Q1t
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2772
CMe
O
Q1t
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2773
CMe
O
Q1t
a bond
H
a bond
NH
S
NH
Q3a
OH


2774
CMe
O
Q1t
a bond
H
a bond
NH
S
NH
Q3b
OH


2775
CMe
O
Q1t
a bond
H
a bond
NH
S
NH
Q3c
OH


2776
CMe
O
Q1t
a bond
H
a bond
NH
S
a bond
Q3a
OH


2777
CMe
O
Q1t
a bond
H
a bond
NH
S
a bond
Q3b
OH


2778
CMe
O
Q1t
a bond
H
a bond
NH
S
a bond
Q3c
OH


2779
CMe
O
Q1t
a bond
H
a bond
NH
O
NH
Q3a
OH


2780
CMe
O
Q1t
a bond
H
a bond
NH
O
NH
Q3b
OH


2781
CMe
O
Q1t
a bond
H
a bond
NH
O
NH
Q3c
OH


2782
CMe
O
Q1t
a bond
H
a bond
NH
O
a bond
Q3a
OH


2783
CMe
O
Q1t
a bond
H
a bond
NH
O
a bond
Q3b
OH


2784
CMe
O
Q1t
a bond
H
a bond
NH
O
a bond
Q3c
OH


2785
CMe
O
Q1u
a bond
Me
a bond
NH
S
NH
Q3a
OH


2786
CMe
O
Q1u
a bond
Me
a bond
NH
S
NH
Q3b
OH


2787
CMe
O
Q1u
a bond
Me
a bond
NH
S
NH
Q3c
OH


2788
CMe
O
Q1u
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2789
CMe
O
Q1u
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2790
CMe
O
Q1u
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2791
CMe
O
Q1u
a bond
Me
a bond
NH
O
NH
Q3a
OH


2792
CMe
O
Q1u
a bond
Me
a bond
NH
O
NH
Q3b
OH


2793
CMe
O
Q1u
a bond
Me
a bond
NH
O
NH
Q3c
OH


2794
CMe
O
Q1u
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2795
CMe
O
Q1u
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2796
CMe
O
Q1u
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2797
CMe
O
Q1u
a bond
H
a bond
NH
S
NH
Q3a
OH


2798
CMe
O
Q1u
a bond
H
a bond
NH
S
NH
Q3b
OH


2799
CMe
O
Q1u
a bond
H
a bond
NH
S
NH
Q3c
OH


2800
CMe
O
Q1u
a bond
H
a bond
NH
S
a bond
Q3a
OH


2801
CMe
O
Q1u
a bond
H
a bond
NH
S
a bond
Q3b
OH


2802
CMe
O
Q1u
a bond
H
a bond
NH
S
a bond
Q3c
OH


2803
CMe
O
Q1u
a bond
H
a bond
NH
O
NH
Q3a
OH


2804
CMe
O
Q1u
a bond
H
a bond
NH
O
NH
Q3b
OH


2805
CMe
O
Q1u
a bond
H
a bond
NH
O
NH
Q3c
OH


2806
CMe
O
Q1u
a bond
H
a bond
NH
O
a bond
Q3a
OH


2807
CMe
O
Q1u
a bond
H
a bond
NH
O
a bond
Q3b
OH


2808
CMe
O
Q1u
a bond
H
a bond
NH
O
a bond
Q3c
OH


2809
CMe
O
Q1v
a bond
Me
a bond
NH
S
NH
Q3a
OH


2810
CMe
O
Q1v
a bond
Me
a bond
NH
S
NH
Q3b
OH


2811
CMe
O
Q1v
a bond
Me
a bond
NH
S
NH
Q3c
OH


2812
CMe
O
Q1v
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2813
CMe
O
Q1v
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2814
CMe
O
Q1v
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2815
CMe
O
Q1v
a bond
Me
a bond
NH
O
NH
Q3a
OH


2816
CMe
O
Q1v
a bond
Me
a bond
NH
O
NH
Q3b
OH


2817
CMe
O
Q1v
a bond
Me
a bond
NH
O
NH
Q3c
OH


2818
CMe
O
Q1v
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2819
CMe
O
Q1v
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2820
CMe
O
Q1v
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2821
CMe
O
Q1v
a bond
H
a bond
NH
S
NH
Q3a
OH


2822
CMe
O
Q1v
a bond
H
a bond
NH
S
NH
Q3b
OH


2823
CMe
O
Q1v
a bond
H
a bond
NH
S
NH
Q3c
OH


2824
CMe
O
Q1v
a bond
H
a bond
NH
S
a bond
Q3a
OH


2825
CMe
O
Q1v
a bond
H
a bond
NH
S
a bond
Q3b
OH


2826
CMe
O
Q1v
a bond
H
a bond
NH
S
a bond
Q3c
OH


2827
CMe
O
Q1v
a bond
H
a bond
NH
O
NH
Q3a
OH


2828
CMe
O
Q1v
a bond
H
a bond
NH
O
NH
Q3b
OH


2829
CMe
O
Q1v
a bond
H
a bond
NH
O
NH
Q3c
OH


2830
CMe
O
Q1v
a bond
H
a bond
NH
O
a bond
Q3a
OH


2831
CMe
O
Q1v
a bond
H
a bond
NH
O
a bond
Q3b
OH


2832
CMe
O
Q1v
a bond
H
a bond
NH
O
a bond
Q3c
OH


2833
CMe
O
Q1w
a bond
Me
a bond
NH
S
NH
Q3a
OH


2834
CMe
O
Q1w
a bond
Me
a bond
NH
S
NH
Q3b
OH


2835
CMe
O
Q1w
a bond
Me
a bond
NH
S
NH
Q3c
OH


2836
CMe
O
Q1w
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2837
CMe
O
Q1w
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2838
CMe
O
Q1w
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2839
CMe
O
Q1w
a bond
Me
a bond
NH
O
NH
Q3a
OH


2840
CMe
O
Q1w
a bond
Me
a bond
NH
O
NH
Q3b
OH


2841
CMe
O
Q1w
a bond
Me
a bond
NH
O
NH
Q3c
OH


2842
CMe
O
Q1w
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2843
CMe
O
Q1w
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2844
CMe
O
Q1w
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2845
CMe
O
Q1w
a bond
H
a bond
NH
S
NH
Q3a
OH


2846
CMe
O
Q1w
a bond
H
a bond
NH
S
NH
Q3b
OH


2847
CMe
O
Q1w
a bond
H
a bond
NH
S
NH
Q3c
OH


2848
CMe
O
Q1w
a bond
H
a bond
NH
S
a bond
Q3a
OH


2849
CMe
O
Q1w
a bond
H
a bond
NH
S
a bond
Q3b
OH


2850
CMe
O
Q1w
a bond
H
a bond
NH
S
a bond
Q3c
OH


2851
CMe
O
Q1w
a bond
H
a bond
NH
O
NH
Q3a
OH


2852
CMe
O
Q1w
a bond
H
a bond
NH
O
NH
Q3b
OH


2853
CMe
O
Q1w
a bond
H
a bond
NH
O
NH
Q3c
OH


2854
CMe
O
Q1w
a bond
H
a bond
NH
O
a bond
Q3a
OH


2855
CMe
O
Q1w
a bond
H
a bond
NH
O
a bond
Q3b
OH


2856
CMe
O
Q1w
a bond
H
a bond
NH
O
a bond
Q3c
OH


2857
CMe
O
Q1x
a bond
Me
a bond
NH
S
NH
Q3a
OH


2858
CMe
O
Q1x
a bond
Me
a bond
NH
S
NH
Q3b
OH


2859
CMe
O
Q1x
a bond
Me
a bond
NH
S
NH
Q3c
OH


2860
CMe
O
Q1x
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2861
CMe
O
Q1x
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2862
CMe
O
Q1x
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2863
CMe
O
Q1x
a bond
Me
a bond
NH
O
NH
Q3a
OH


2864
CMe
O
Q1x
a bond
Me
a bond
NH
O
NH
Q3b
OH


2865
CMe
O
Q1x
a bond
Me
a bond
NH
O
NH
Q3c
OH


2866
CMe
O
Q1x
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2867
CMe
O
Q1x
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2868
CMe
O
Q1x
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2869
CMe
O
Q1x
a bond
H
a bond
NH
S
NH
Q3a
OH


2870
CMe
O
Q1x
a bond
H
a bond
NH
S
NH
Q3b
OH


2871
CMe
O
Q1x
a bond
H
a bond
NH
S
NH
Q3c
OH


2872
CMe
O
Q1x
a bond
H
a bond
NH
S
a bond
Q3a
OH


2873
CMe
O
Q1x
a bond
H
a bond
NH
S
a bond
Q3b
OH


2874
CMe
O
Q1x
a bond
H
a bond
NH
S
a bond
Q3c
OH


2875
CMe
O
Q1x
a bond
H
a bond
NH
O
NH
Q3a
OH


2876
CMe
O
Q1x
a bond
H
a bond
NH
O
NH
Q3b
OH


2877
CMe
O
Q1x
a bond
H
a bond
NH
O
NH
Q3c
OH


2878
CMe
O
Q1x
a bond
H
a bond
NH
O
a bond
Q3a
OH


2879
CMe
O
Q1x
a bond
H
a bond
NH
O
a bond
Q3b
OH


2880
CMe
O
Q1x
a bond
H
a bond
NH
O
a bond
Q3c
OH


2881
CH
NH
Q1o
a bond
Me
a bond
NH
S
NH
Q3a
OH


2882
CH
NH
Q1o
a bond
Me
a bond
NH
S
NH
Q3b
OH


2883
CH
NH
Q1o
a bond
Me
a bond
NH
S
NH
Q3c
OH


2884
CH
NH
Q1o
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2885
CH
NH
Q1o
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2886
CH
NH
Q1o
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2887
CH
NH
Q1o
a bond
Me
a bond
NH
O
NH
Q3a
OH


2888
CH
NH
Q1o
a bond
Me
a bond
NH
O
NH
Q3b
OH


2889
CH
NH
Q1o
a bond
Me
a bond
NH
O
NH
Q3c
OH


2890
CH
NH
Q1o
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2891
CH
NH
Q1o
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2892
CH
NH
Q1o
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2893
CH
NH
Q1o
a bond
H
a bond
NH
S
NH
Q3a
OH


2894
CH
NH
Q1o
a bond
H
a bond
NH
S
NH
Q3b
OH


2895
CH
NH
Q1o
a bond
H
a bond
NH
S
NH
Q3c
OH


2896
CH
NH
Q1o
a bond
H
a bond
NH
S
a bond
Q3a
OH


2897
CH
NH
Q1o
a bond
H
a bond
NH
S
a bond
Q3b
OH


2898
CH
NH
Q1o
a bond
H
a bond
NH
S
a bond
Q3c
OH


2899
CH
NH
Q1o
a bond
H
a bond
NH
O
NH
Q3a
OH


2900
CH
NH
Q1o
a bond
H
a bond
NH
O
NH
Q3b
OH


2901
CH
NH
Q1o
a bond
H
a bond
NH
O
NH
Q3c
OH


2902
CH
NH
Q1o
a bond
H
a bond
NH
O
a bond
Q3a
OH


2903
CH
NH
Q1o
a bond
H
a bond
NH
O
a bond
Q3b
OH


2904
CH
NH
Q1o
a bond
H
a bond
NH
O
a bond
Q3c
OH


2905
CH
NH
Qip
a bond
Me
a bond
NH
S
NH
Q3a
OH


2906
CH
NH
Q1p
a bond
Me
a bond
NH
S
NH
Q3b
OH


2907
CH
NH
Q1p
a bond
Me
a bond
NH
S
NH
Q3c
OH


2908
CH
NH
Q1p
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2909
CH
NH
Q1p
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2910
CH
NH
Q1p
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2911
CH
NH
Q1p
a bond
Me
a bond
NH
O
NH
Q3a
OH


2912
CH
NH
Q1p
a bond
Me
a bond
NH
O
NH
Q3b
OH


2913
CH
NH
Q1p
a bond
Me
a bond
NH
O
NH
Q3c
OH


2914
CH
NH
Q1p
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2915
CH
NH
Q1p
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2916
CH
NH
Q1p
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2917
CH
NH
Q1p
a bond
H
a bond
NH
S
NH
Q3a
OH


2918
CH
NH
Q1p
a bond
H
a bond
NH
S
NH
Q3b
OH


2919
CH
NH
Q1p
a bond
H
a bond
NH
S
NH
Q3c
OH


2920
CH
NH
Q1p
a bond
H
a bond
NH
S
a bond
Q3a
OH


2921
CH
NH
Q1p
a bond
H
a bond
NH
S
a bond
Q3b
OH


2922
CH
NH
Q1p
a bond
H
a bond
NH
S
a bond
Q3c
OH


2923
CH
NH
Q1p
a bond
H
a bond
NH
O
NH
Q3a
OH


2924
CH
NH
Q1p
a bond
H
a bond
NH
O
NH
Q3b
OH


2925
CH
NH
Q1p
a bond
H
a bond
NH
O
NH
Q3c
OH


2926
CH
NH
Q1p
a bond
H
a bond
NH
O
a bond
Q3a
OH


2927
CH
NH
Q1p
a bond
H
a bond
NH
O
a bond
Q3b
OH


2928
CH
NH
Q1p
a bond
H
a bond
NH
O
a bond
Q3c
OH


2929
CH
NH
Q1q
a bond
Me
a bond
NH
S
NH
Q3a
OH


2930
CH
NH
Q1q
a bond
Me
a bond
NH
S
NH
Q3b
OH


2931
CH
NH
Q1q
a bond
Me
a bond
NH
S
NH
Q3c
OH


2932
CH
NH
Q1q
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2933
CH
NH
Q1q
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2934
CH
NH
Q1q
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2935
CH
NH
Q1q
a bond
Me
a bond
NH
O
NH
Q3a
OH


2936
CH
NH
Q1q
a bond
Me
a bond
NH
O
NH
Q3b
OH


2937
CH
NH
Q1q
a bond
Me
a bond
NH
O
NH
Q3c
OH


2938
CH
NH
Q1q
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2939
CH
NH
Q1q
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2940
CH
NH
Q1q
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2941
CH
NH
Q1q
a bond
H
a bond
NH
S
NH
Q3a
OH


2942
CH
NH
Q1q
a bond
H
a bond
NH
S
NH
Q3b
OH


2943
CH
NH
Q1q
a bond
H
a bond
NH
S
NH
Q3c
OH


2944
CH
NH
Q1q
a bond
H
a bond
NH
S
a bond
Q3a
OH


2945
CH
NH
Q1q
a bond
H
a bond
NH
S
a bond
Q3b
OH


2946
CH
NH
Q1q
a bond
H
a bond
NH
S
a bond
Q3c
OH


2947
CH
NH
Q1q
a bond
H
a bond
NH
O
NH
Q3a
OH


2948
CH
NH
Q1q
a bond
H
a bond
NH
O
NH
Q3b
OH


2949
CH
NH
Q1q
a bond
H
a bond
NH
O
NH
Q3c
OH


2950
CH
NH
Q1q
a bond
H
a bond
NH
O
a bond
Q3a
OH


2951
CH
NH
Q1q
a bond
H
a bond
NH
O
a bond
Q3b
OH


2952
CH
NH
Q1q
a bond
H
a bond
NH
O
a bond
Q3c
OH


2953
CH
NH
Q1r
a bond
Me
a bond
NH
S
NH
Q3a
OH


2954
CH
NH
Q1r
a bond
Me
a bond
NH
S
NH
Q3b
OH


2955
CH
NH
Q1r
a bond
Me
a bond
NH
S
NH
Q3c
OH


2956
CH
NH
Q1r
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2957
CH
NH
Q1r
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2958
CH
NH
Q1r
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2959
CH
NH
Q1r
a bond
Me
a bond
NH
O
NH
Q3a
OH


2960
CH
NH
Q1r
a bond
Me
a bond
NH
O
NH
Q3b
OH


2961
CH
NH
Q1r
a bond
Me
a bond
NH
O
NH
Q3c
OH


2962
CH
NH
Q1r
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2963
CH
NH
Q1r
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2964
CH
NH
Q1r
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2965
CH
NH
Q1r
a bond
H
a bond
NH
S
NH
Q3a
OH


2966
CH
NH
Q1r
a bond
H
a bond
NH
S
NH
Q3b
OH


2967
CH
NH
Q1r
a bond
H
a bond
NH
S
NH
Q3c
OH


2968
CH
NH
Q1r
a bond
H
a bond
NH
S
a bond
Q3a
OH


2969
CH
NH
Q1r
a bond
H
a bond
NH
S
a bond
Q3b
OH


2970
CH
NH
Q1r
a bond
H
a bond
NH
S
a bond
Q3c
OH


2971
CH
NH
Q1r
a bond
H
a bond
NH
O
NH
Q3a
OH


2972
CH
NH
Q1r
a bond
H
a bond
NH
O
NH
Q3b
OH


2973
CH
NH
Q1r
a bond
H
a bond
NH
O
NH
Q3c
OH


2974
CH
NH
Q1r
a bond
H
a bond
NH
O
a bond
Q3a
OH


2975
CH
NH
Q1r
a bond
H
a bond
NH
O
a bond
Q3b
OH


2976
CH
NH
Q1r
a bond
H
a bond
NH
O
a bond
Q3c
OH


2977
CH
NH
Q1s
a bond
Me
a bond
NH
S
NH
Q3a
OH


2978
CH
NH
Q1s
a bond
Me
a bond
NH
S
NH
Q3b
OH


2979
CH
NH
Q1s
a bond
Me
a bond
NH
S
NH
Q3c
OH


2980
CH
NH
Q1s
a bond
Me
a bond
NH
S
a bond
Q3a
OH


2981
CH
NH
Q1s
a bond
Me
a bond
NH
S
a bond
Q3b
OH


2982
CH
NH
Q1s
a bond
Me
a bond
NH
S
a bond
Q3c
OH


2983
CH
NH
Q1s
a bond
Me
a bond
NH
O
NH
Q3a
OH


2984
CH
NH
Q1s
a bond
Me
a bond
NH
O
NH
Q3b
OH


2985
CH
NH
Q1s
a bond
Me
a bond
NH
O
NH
Q3c
OH


2986
CH
NH
Q1s
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2987
CH
NH
Q1s
a bond
Me
a bond
NH
O
a bond
Q3b
OH


2988
CH
NH
Q1s
a bond
Me
a bond
NH
O
a bond
Q3c
OH


2989
CH
NH
Q1s
a bond
H
a bond
NH
S
NH
Q3a
OH


2990
CH
NH
Q1s
a bond
H
a bond
NH
S
NH
Q3b
OH


2991
CH
NH
Q1s
a bond
H
a bond
NH
S
NH
Q3c
OH


2992
CH
NH
Q1s
a bond
H
a bond
NH
S
a bond
Q3a
OH


2993
CH
NH
Q1s
a bond
H
a bond
NH
S
a bond
Q3b
OH


2994
CH
NH
Q1s
a bond
H
a bond
NH
S
a bond
Q3c
OH


2995
CH
NH
Q1s
a bond
H
a bond
NH
O
NH
Q3a
OH


2996
CH
NH
Q1s
a bond
H
a bond
NH
O
NH
Q3b
OH


2997
CH
NH
Q1s
a bond
H
a bond
NH
O
NH
Q3c
OH


2998
CH
NH
Q1s
a bond
H
a bond
NH
O
a bond
Q3a
OH


2999
CH
NH
Q1s
a bond
H
a bond
NH
O
a bond
Q3b
OH


3000
CH
NH
Q1s
a bond
H
a bond
NH
O
a bond
Q3c
OH


3001
CH
NH
Q1t
a bond
Me
a bond
NH
S
NH
Q3a
OH


3002
CH
NH
Q1t
a bond
Me
a bond
NH
S
NH
Q3b
OH


3003
CH
NH
Q1t
a bond
Me
a bond
NH
S
NH
Q3c
OH


3004
CH
NH
Q1t
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3005
CH
NH
Q1t
a bond
Me
a bond
NH
S
a bond
Q3b
OH


3006
CH
NH
Q1t
a bond
Me
a bond
NH
S
a bond
Q3c
OH


3007
CH
NH
Q1t
a bond
Me
a bond
NH
O
NH
Q3a
OH


3008
CH
NH
Q1t
a bond
Me
a bond
NH
O
NH
Q3b
OH


3009
CH
NH
Q1t
a bond
Me
a bond
NH
O
NH
Q3c
OH


3010
CH
NH
Q1t
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3011
CH
NH
Q1t
a bond
Me
a bond
NH
O
a bond
Q3b
OH


3012
CH
NH
Q1t
a bond
Me
a bond
NH
O
a bond
Q3c
OH


3013
CH
NH
Q1t
a bond
H
a bond
NH
S
NH
Q3a
OH


3014
CH
NH
Q1t
a bond
H
a bond
NH
S
NH
Q3b
OH


3015
CH
NH
Q1t
a bond
H
a bond
NH
S
NH
Q3c
OH


3016
CH
NH
Q1t
a bond
H
a bond
NH
S
a bond
Q3a
OH


3017
CH
NH
Q1t
a bond
H
a bond
NH
S
a bond
Q3b
OH


3018
CH
NH
Q1t
a bond
H
a bond
NH
S
a bond
Q3c
OH


3019
CH
NH
Q1t
a bond
H
a bond
NH
O
NH
Q3a
OH


3020
CH
NH
Q1t
a bond
H
a bond
NH
O
NH
Q3b
OH


3021
CH
NH
Q1t
a bond
H
a bond
NH
O
NH
Q3c
OH


3022
CH
NH
Q1t
a bond
H
a bond
NH
O
a bond
Q3a
OH


3023
CH
NH
Q1t
a bond
H
a bond
NH
O
a bond
Q3b
OH


3024
CH
NH
Q1t
a bond
H
a bond
NH
O
a bond
Q3c
OH


3025
CH
NH
Q1u
a bond
Me
a bond
NH
S
NH
Q3a
OH


3026
CH
NH
Q1u
a bond
Me
a bond
NH
S
NH
Q3b
OH


3027
CH
NH
Q1u
a bond
Me
a bond
NH
S
NH
Q3c
OH


3028
CH
NH
Q1u
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3029
CH
NH
Q1u
a bond
Me
a bond
NH
S
a bond
Q3b
OH


3030
CH
NH
Q1u
a bond
Me
a bond
NH
S
a bond
Q3c
OH


3031
CH
NH
Q1u
a bond
Me
a bond
NH
O
NH
Q3a
OH


3032
CH
NH
Q1u
a bond
Me
a bond
NH
O
NH
Q3b
OH


3033
CH
NH
Q1u
a bond
Me
a bond
NH
O
NH
Q3c
OH


3034
CH
NH
Q1u
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3035
CH
NH
Q1u
a bond
Me
a bond
NH
O
a bond
Q3b
OH


3036
CH
NH
Q1u
a bond
Me
a bond
NH
O
a bond
Q3c
OH


3037
CH
NH
Q1u
a bond
H
a bond
NH
S
NH
Q3a
OH


3038
CH
NH
Q1u
a bond
H
a bond
NH
S
NH
Q3b
OH


3039
CH
NH
Q1u
a bond
H
a bond
NH
S
NH
Q3c
OH


3040
CH
NH
Q1u
a bond
H
a bond
NH
S
a bond
Q3a
OH


3041
CH
NH
Q1u
a bond
H
a bond
NH
S
a bond
Q3b
OH


3042
CH
NH
Q1u
a bond
H
a bond
NH
S
a bond
Q3c
OH


3043
CH
NH
Q1u
a bond
H
a bond
NH
O
NH
Q3a
OH


3044
CH
NH
Q1u
a bond
H
a bond
NH
O
NH
Q3b
OH


3045
CH
NH
Q1u
a bond
H
a bond
NH
O
NH
Q3c
OH


3046
CH
NH
Q1u
a bond
H
a bond
NH
O
a bond
Q3a
OH


3047
CH
NH
Q1u
a bond
H
a bond
NH
O
a bond
Q3b
OH


3048
CH
NH
Q1u
a bond
H
a bond
NH
O
a bond
Q3c
OH


3049
CH
NH
Q1v
a bond
Me
a bond
NH
S
NH
Q3a
OH


3050
CH
NH
Q1v
a bond
Me
a bond
NH
S
NH
Q3b
OH


3051
CH
NH
Q1v
a bond
Me
a bond
NH
S
NH
Q3c
OH


3052
CH
NH
Q1v
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3053
CH
NH
Q1v
a bond
Me
a bond
NH
S
a bond
Q3b
OH


3054
CH
NH
Q1v
a bond
Me
a bond
NH
S
a bond
Q3c
OH


3055
CH
NH
Q1v
a bond
Me
a bond
NH
O
NH
Q3a
OH


3056
CH
NH
Q1v
a bond
Me
a bond
NH
O
NH
Q3b
OH


3057
CH
NH
Q1v
a bond
Me
a bond
NH
O
NH
Q3c
OH


3058
CH
NH
Q1v
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3059
CH
NH
Q1v
a bond
Me
a bond
NH
O
a bond
Q3b
OH


3060
CH
NH
Q1v
a bond
Me
a bond
NH
O
a bond
Q3c
OH


3061
CH
NH
Q1v
a bond
H
a bond
NH
S
NH
Q3a
OH


3062
CH
NH
Q1v
a bond
H
a bond
NH
S
NH
Q3b
OH


3063
CH
NH
Q1v
a bond
H
a bond
NH
S
NH
Q3c
OH


3064
CH
NH
Q1v
a bond
H
a bond
NH
S
a bond
Q3a
OH


3065
CH
NH
Q1v
a bond
H
a bond
NH
S
a bond
Q3b
OH


3066
CH
NH
Q1v
a bond
H
a bond
NH
S
a bond
Q3c
OH


3067
CH
NH
Q1v
a bond
H
a bond
NH
O
NH
Q3a
OH


3068
CH
NH
Q1v
a bond
H
a bond
NH
O
NH
Q3b
OH


3069
CH
NH
Q1v
a bond
H
a bond
NH
O
NH
Q3c
OH


3070
CH
NH
Q1v
a bond
H
a bond
NH
O
a bond
Q3a
OH


3071
CH
NH
Q1v
a bond
H
a bond
NH
O
a bond
Q3b
OH


3072
CH
NH
Q1v
a bond
H
a bond
NH
O
a bond
Q3c
OH


3073
CH
NH
Q1w
a bond
Me
a bond
NH
S
NH
Q3a
OH


3074
CH
NH
Q1w
a bond
Me
a bond
NH
S
NH
Q3b
OH


3075
CH
NH
Q1w
a bond
Me
a bond
NH
S
NH
Q3c
OH


3076
N
NMe
Q1y
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3077
N
NMe
Q1z
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3078
CH
NH
Q1w
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3079
CH
NH
Q1w
a bond
Me
a bond
NH
S
a bond
Q3b
OH


3080
CH
NH
Q1w
a bond
Me
a bond
NH
S
a bond
Q3c
OH


3081
CH
NH
Q1w
a bond
Me
a bond
NH
O
NH
Q3a
OH


3082
CH
NH
Q1w
a bond
Me
a bond
NH
O
NH
Q3b
OH


3083
CH
NH
Q1w
a bond
Me
a bond
NH
O
NH
Q3c
OH


3084
CH
NH
Q1w
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3085
CH
NH
Q1w
a bond
Me
a bond
NH
O
a bond
Q3b
OH


3086
CH
NH
Q1w
a bond
Me
a bond
NH
O
a bond
Q3c
OH


3087
CH
NH
Q1w
a bond
H
a bond
NH
S
NH
Q3a
OH


3088
CH
NH
Q1w
a bond
H
a bond
NH
S
NH
Q3b
OH


3089
CH
NH
Q1w
a bond
H
a bond
NH
S
NH
Q3c
OH


3090
CH
NH
Q1w
a bond
H
a bond
NH
S
a bond
Q3a
OH


3091
CH
NH
Q1w
a bond
H
a bond
NH
S
a bond
Q3b
OH


3092
CH
NH
Q1w
a bond
H
a bond
NH
S
a bond
Q3c
OH


3093
CH
NH
Q1w
a bond
H
a bond
NH
O
NH
Q3a
OH


3094
CH
NH
Q1w
a bond
H
a bond
NH
O
NH
Q3b
OH


3095
CH
NH
Q1w
a bond
H
a bond
NH
O
NH
Q3c
OH


3096
CH
NH
Q1w
a bond
H
a bond
NH
O
a bond
Q3a
OH


3097
CH
NH
Q1w
a bond
H
a bond
NH
O
a bond
Q3b
OH


3098
CH
NH
Q1w
a bond
H
a bond
NH
O
a bond
Q3c
OH


3099
CH
NH
Q1x
a bond
Me
a bond
NH
S
NH
Q3a
OH


3100
CH
NH
Q1x
a bond
Me
a bond
NH
S
NH
Q3b
OH


3101
CH
NH
Q1x
a bond
Me
a bond
NH
S
NH
Q3c
OH


3102
CH
NH
Q1x
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3103
CH
NH
Q1x
a bond
Me
a bond
NH
S
a bond
Q3b
OH


3104
CH
NH
Q1x
a bond
Me
a bond
NH
S
a bond
Q3c
OH


3105
CH
NH
Q1x
a bond
Me
a bond
NH
O
NH
Q3a
OH


3106
CH
NH
Q1x
a bond
Me
a bond
NH
O
NH
Q3b
OH


3107
CH
NH
Q1x
a bond
Me
a bond
NH
O
NH
Q3c
OH


3108
CH
NH
Q1x
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3109
CH
NH
Q1x
a bond
Me
a bond
NH
O
a bond
Q3b
OH


3110
CH
NH
Q1x
a bond
Me
a bond
NH
O
a bond
Q3c
OH


3111
CH
NH
Q1x
a bond
H
a bond
NH
S
NH
Q3a
OH


3112
CH
NH
Q1x
a bond
H
a bond
NH
S
NH
Q3b
OH


3113
CH
NH
Q1x
a bond
H
a bond
NH
S
NH
Q3c
OH


3114
CH
NH
Q1x
a bond
H
a bond
NH
S
a bond
Q3a
OH


3115
CH
NH
Q1x
a bond
H
a bond
NH
S
a bond
Q3b
OH


3116
CH
NH
Q1x
a bond
H
a bond
NH
S
a bond
Q3c
OH


3117
CH
NH
Q1x
a bond
H
a bond
NH
O
NH
Q3a
OH


3118
CH
NH
Q1x
a bond
H
a bond
NH
O
NH
Q3b
OH


3119
CH
NH
Q1x
a bond
H
a bond
NH
O
NH
Q3c
OH


3120
CH
NH
Q1x
a bond
H
a bond
NH
O
a bond
Q3a
OH


3121
CH
NH
Q1x
a bond
H
a bond
NH
O
a bond
Q3b
OH


3122
CH
NH
Q1x
a bond
H
a bond
NH
O
a bond
Q3c
OH


3123
CMe
NH
Q1o
a bond
Me
a bond
NH
S
NH
Q3a
OH


3124
CMe
NH
Q1o
a bond
Me
a bond
NH
S
NH
Q3b
OH


3125
CMe
NH
Q1o
a bond
Me
a bond
NH
S
NH
Q3c
OH


3126
CMe
NH
Q1o
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3127
CMe
NH
Q1o
a bond
Me
a bond
NH
S
a bond
Q3b
OH


3128
CMe
NH
Q1o
a bond
Me
a bond
NH
S
a bond
Q3c
OH


3129
CMe
NH
Q1o
a bond
Me
a bond
NH
O
NH
Q3a
OH


3130
CMe
NH
Q1o
a bond
Me
a bond
NH
O
NH
Q3b
OH


3131
CMe
NH
Q1o
a bond
Me
a bond
NH
O
NH
Q3c
OH


3132
CMe
NH
Q1o
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3133
CMe
NH
Q1o
a bond
Me
a bond
NH
O
a bond
Q3b
OH


3134
CMe
NH
Q1o
a bond
Me
a bond
NH
O
a bond
Q3c
OH


3135
CMe
NH
Q1o
a bond
H
a bond
NH
S
NH
Q3a
OH


3136
CMe
NH
Q1o
a bond
H
a bond
NH
S
NH
Q3b
OH


3137
CMe
NH
Q1o
a bond
H
a bond
NH
S
NH
Q3c
OH


3138
CMe
NH
Q1o
a bond
H
a bond
NH
S
a bond
Q3a
OH


3139
CMe
NH
Q1o
a bond
H
a bond
NH
S
a bond
Q3b
OH


3140
CMe
NH
Q1o
a bond
H
a bond
NH
S
a bond
Q3c
OH


3141
CMe
NH
Q1o
a bond
H
a bond
NH
O
NH
Q3a
OH


3142
CMe
NH
Q1o
a bond
H
a bond
NH
O
NH
Q3b
OH


3143
CMe
NH
Q1o
a bond
H
a bond
NH
O
NH
Q3c
OH


3144
CMe
NH
Q1o
a bond
H
a bond
NH
O
a bond
Q3a
OH


3145
CMe
NH
Q1o
a bond
H
a bond
NH
O
a bond
Q3b
OH


3146
CMe
NH
Q1o
a bond
H
a bond
NH
O
a bond
Q3c
OH


3147
CMe
NH
Q1p
a bond
Me
a bond
NH
S
NH
Q3a
OH


3148
CMe
NH
Q1p
a bond
Me
a bond
NH
S
NH
Q3b
OH


3149
CMe
NH
Q1p
a bond
Me
a bond
NH
S
NH
Q3c
OH


3150
CMe
NH
Q1p
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3151
CMe
NH
Q1p
a bond
Me
a bond
NH
S
a bond
Q3b
OH


3152
CMe
NH
Q1p
a bond
Me
a bond
NH
S
a bond
Q3c
OH


3153
CMe
NH
Q1p
a bond
Me
a bond
NH
O
NH
Q3a
OH


3154
CMe
NH
Q1p
a bond
Me
a bond
NH
O
NH
Q3b
OH


3155
CMe
NH
Q1p
a bond
Me
a bond
NH
O
NH
Q3c
OH


3156
CMe
NH
Q1p
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3157
CMe
NH
Q1p
a bond
Me
a bond
NH
O
a bond
Q3b
OH


3158
CMe
NH
Q1p
a bond
Me
a bond
NH
O
a bond
Q3c
OH


3159
CMe
NH
Q1p
a bond
H
a bond
NH
S
NH
Q3a
OH


3160
CMe
NH
Q1p
a bond
H
a bond
NH
S
NH
Q3b
OH


3161
CMe
NH
Q1p
a bond
H
a bond
NH
S
NH
Q3c
OH


3162
CMe
NH
Q1p
a bond
H
a bond
NH
S
a bond
Q3a
OH


3163
CMe
NH
Q1p
a bond
H
a bond
NH
S
a bond
Q3b
OH


3164
CMe
NH
Q1p
a bond
H
a bond
NH
S
a bond
Q3c
OH


3165
CMe
NH
Q1p
a bond
H
a bond
NH
O
NH
Q3a
OH


3166
CMe
NH
Q1p
a bond
H
a bond
NH
O
NH
Q3b
OH


3167
CMe
NH
Q1p
a bond
H
a bond
NH
O
NH
Q3c
OH


3168
CMe
NH
Q1p
a bond
H
a bond
NH
O
a bond
Q3a
OH


3169
CMe
NH
Q1p
a bond
H
a bond
NH
O
a bond
Q3b
OH


3170
CMe
NH
Q1p
a bond
H
a bond
NH
O
a bond
Q3c
OH


3171
CMe
NH
Q1q
a bond
Me
a bond
NH
S
NH
Q3a
OH


3172
CMe
NH
Q1q
a bond
Me
a bond
NH
S
NH
Q3b
OH


3173
CMe
NH
Q1q
a bond
Me
a bond
NH
S
NH
Q3c
OH


3174
CMe
NH
Q1q
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3175
CMe
NH
Q1q
a bond
Me
a bond
NH
S
a bond
Q3b
OH


3176
CMe
NH
Q1q
a bond
Me
a bond
NH
S
a bond
Q3c
OH


3177
CMe
NH
Q1q
a bond
Me
a bond
NH
O
NH
Q3a
OH


3178
CMe
NH
Q1q
a bond
Me
a bond
NH
O
NH
Q3b
OH


3179
CMe
NH
Q1q
a bond
Me
a bond
NH
O
NH
Q3c
OH


3180
CMe
NH
Q1q
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3181
CMe
NH
Q1q
a bond
Me
a bond
NH
O
a bond
Q3b
OH


3182
CMe
NH
Q1p
a bond
Me
a bond
NH
O
a bond
Q3c
OH


3183
CMe
NH
Q1q
a bond
H
a bond
NH
S
NH
Q3a
OH


3184
CMe
NH
Q1q
a bond
H
a bond
NH
S
NH
Q3b
OH


3185
CMe
NH
Q1q
a bond
H
a bond
NH
S
NH
Q3c
OH


3186
CMe
NH
Q1q
a bond
H
a bond
NH
S
a bond
Q3a
OH


3187
CMe
NH
Q1q
a bond
H
a bond
NH
S
a bond
Q3b
OH


3188
CMe
NH
Q1q
a bond
H
a bond
NH
S
a bond
Q3c
OH


3189
CMe
NH
Q1q
a bond
H
a bond
NH
O
NH
Q3a
OH


3190
CMe
NH
Q1q
a bond
H
a bond
NH
O
NH
Q3b
OH


3191
CMe
NH
Q1q
a bond
H
a bond
NH
O
NH
Q3c
OH


3192
CMe
NH
Q1q
a bond
H
a bond
NH
O
a bond
Q3a
OH


3193
CMe
NH
Q1q
a bond
H
a bond
NH
O
a bond
Q3b
OH


3194
CMe
NH
Q1q
a bond
H
a bond
NH
O
a bond
Q3c
OH


3195
CMe
NH
Q1r
a bond
Me
a bond
NH
S
NH
Q3a
OH


3196
CMe
NH
Q1r
a bond
Me
a bond
NH
S
NH
Q3b
OH


3197
CMe
NH
Q1r
a bond
Me
a bond
NH
S
NH
Q3c
OH


3198
CMe
NH
Q1r
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3199
CMe
NH
Q1r
a bond
Me
a bond
NH
S
a bond
Q3b
OH


3200
CMe
NH
Q1r
a bond
Me
a bond
NH
S
a bond
Q3c
OH


3201
CMe
NH
Q1r
a bond
Me
a bond
NH
O
NH
Q3a
OH


3202
CMe
NH
Q1r
a bond
Me
a bond
NH
O
NH
Q3b
OH


3203
CMe
NH
Q1r
a bond
Me
a bond
NH
O
NH
Q3c
OH


3204
CMe
NH
Q1r
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3205
CMe
NH
Q1r
a bond
Me
a bond
NH
O
a bond
Q3b
OH


3206
CMe
NH
Q1r
a bond
Me
a bond
NH
O
a bond
Q3c
OH


3207
CMe
NH
Q1r
a bond
H
a bond
NH
S
NH
Q3a
OH


3208
CMe
NH
Q1r
a bond
H
a bond
NH
S
NH
Q3b
OH


3209
CMe
NH
Q1r
a bond
H
a bond
NH
S
NH
Q3c
OH


3210
CMe
NH
Q1r
a bond
H
a bond
NH
S
a bond
Q3a
OH


3211
CMe
NH
Q1r
a bond
H
a bond
NH
S
a bond
Q3b
OH


3212
CMe
NH
Q1r
a bond
H
a bond
NH
S
a bond
Q3c
OH


3213
CMe
NH
Q1r
a bond
H
a bond
NH
O
NH
Q3a
OH


3214
CMe
NH
Q1r
a bond
H
a bond
NH
O
NH
Q3b
OH


3215
CMe
NH
Q1r
a bond
H
a bond
NH
O
NH
Q3c
OH


3216
CMe
NH
Q1r
a bond
H
a bond
NH
O
a bond
Q3a
OH


3217
CMe
NH
Q1r
a bond
H
a bond
NH
O
a bond
Q3b
OH


3218
CMe
NH
Q1r
a bond
H
a bond
NH
O
a bond
Q3c
OH


3219
CMe
NH
Q1s
a bond
Me
a bond
NH
S
NH
Q3a
OH


3220
CMe
NH
Q1s
a bond
Me
a bond
NH
S
NH
Q3b
OH


3221
CMe
NH
Q1s
a bond
Me
a bond
NH
S
NH
Q3c
OH


3222
CMe
NH
Q1s
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3223
CMe
NH
Q1s
a bond
Me
a bond
NH
S
a bond
Q3b
OH


3224
CMe
NH
Q1s
a bond
Me
a bond
NH
S
a bond
Q3c
OH


3225
CMe
NH
Q1s
a bond
Me
a bond
NH
O
NH
Q3a
OH


3226
CMe
NH
Q1s
a bond
Me
a bond
NH
O
NH
Q3b
OH


3227
CMe
NH
Q1s
a bond
Me
a bond
NH
O
NH
Q3c
OH


3228
CMe
NH
Q1s
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3229
CMe
NH
Q1s
a bond
Me
a bond
NH
O
a bond
Q3b
OH


3230
CMe
NH
Q1s
a bond
Me
a bond
NH
O
a bond
Q3c
OH


3231
CMe
NH
Q1s
a bond
H
a bond
NH
S
NH
Q3a
OH


3232
CMe
NH
Q1s
a bond
H
a bond
NH
S
NH
Q3b
OH


3233
CMe
NH
Q1s
a bond
H
a bond
NH
S
NH
Q3c
OH


3234
CMe
NH
Q1s
a bond
H
a bond
NH
S
a bond
Q3a
OH


3235
CMe
NH
Q1s
a bond
H
a bond
NH
S
a bond
Q3b
OH


3236
CMe
NH
Q1s
a bond
H
a bond
NH
S
a bond
Q3c
OH


3237
CMe
NH
Q1s
a bond
H
a bond
NH
O
NH
Q3a
OH


3238
CMe
NH
Q1s
a bond
H
a bond
NH
O
NH
Q3b
OH


3239
CMe
NH
Q1s
a bond
H
a bond
NH
O
NH
Q3c
OH


3240
CMe
NH
Q1s
a bond
H
a bond
NH
O
a bond
Q3a
OH


3241
CMe
NH
Q1s
a bond
H
a bond
NH
O
a bond
Q3b
OH


3242
CMe
NH
Q1s
a bond
H
a bond
NH
O
a bond
Q3c
OH


3243
CMe
NH
Q1t
a bond
Me
a bond
NH
S
NH
Q3a
OH


3244
CMe
NH
Q1t
a bond
Me
a bond
NH
S
NH
Q3b
OH


3245
CMe
NH
Q1t
a bond
Me
a bond
NH
S
NH
Q3c
OH


3246
CMe
NH
Q1t
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3247
CMe
NH
Q1t
a bond
Me
a bond
NH
S
a bond
Q3b
OH


3248
CMe
NH
Q1t
a bond
Me
a bond
NH
S
a bond
Q3c
OH


3249
CMe
NH
Q1t
a bond
Me
a bond
NH
O
NH
Q3a
OH


3250
CMe
NH
Q1t
a bond
Me
a bond
NH
O
NH
Q3b
OH


3251
CMe
NH
Q1t
a bond
Me
a bond
NH
O
NH
Q3c
OH


3252
CMe
NH
Q1t
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3253
CMe
NH
Q1t
a bond
Me
a bond
NH
O
a bond
Q3b
OH


3254
CMe
NH
Q1t
a bond
Me
a bond
NH
O
a bond
Q3c
OH


3255
CMe
NH
Q1t
a bond
H
a bond
NH
S
NH
Q3a
OH


3256
CMe
NH
Q1t
a bond
H
a bond
NH
S
NH
Q3b
OH


3257
CMe
NH
Q1t
a bond
H
a bond
NH
S
NH
Q3c
OH


3258
CMe
NH
Q1t
a bond
H
a bond
NH
S
a bond
Q3a
OH


3259
CMe
NH
Q1t
a bond
H
a bond
NH
S
a bond
Q3b
OH


3260
CMe
NH
Q1t
a bond
H
a bond
NH
S
a bond
Q3c
OH


3261
CMe
NH
Q1t
a bond
H
a bond
NH
O
NH
Q3a
OH


3262
CMe
NH
Q1t
a bond
H
a bond
NH
O
NH
Q3b
OH


3263
CMe
NH
Q1t
a bond
H
a bond
NH
O
NH
Q3c
OH


3264
CMe
NH
Q1t
a bond
H
a bond
NH
O
a bond
Q3a
OH


3265
CMe
NH
Q1t
a bond
H
a bond
NH
O
a bond
Q3b
OH


3266
CMe
NH
Q1t
a bond
H
a bond
NH
O
a bond
Q3c
OH


3267
CMe
NH
Q1u
a bond
Me
a bond
NH
S
NH
Q3a
OH


3268
CMe
NH
Q1u
a bond
Me
a bond
NH
S
NH
Q3b
OH


3269
CMe
NH
Q1u
a bond
Me
a bond
NH
S
NH
Q3c
OH


3270
CMe
NH
Q1u
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3271
CMe
NH
Q1u
a bond
Me
a bond
NH
S
a bond
Q3b
OH


3272
CMe
NH
Q1u
a bond
Me
a bond
NH
S
a bond
Q3c
OH


3273
CMe
NH
Q1u
a bond
Me
a bond
NH
O
NH
Q3a
OH


3274
CMe
NH
Q1u
a bond
Me
a bond
NH
O
NH
Q3b
OH


3275
CMe
NH
Q1u
a bond
Me
a bond
NH
O
NH
Q3c
OH


3276
CMe
NH
Q1u
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3277
CMe
NH
Q1u
a bond
Me
a bond
NH
O
a bond
Q3b
OH


3278
CMe
NH
Q1u
a bond
Me
a bond
NH
O
a bond
Q3c
OH


3279
CMe
NH
Q1u
a bond
H
a bond
NH
S
NH
Q3a
OH


3280
CMe
NH
Q1u
a bond
H
a bond
NH
S
NH
Q3b
OH


3281
CMe
NH
Q1u
a bond
H
a bond
NH
S
NH
Q3c
OH


3282
CMe
NH
Q1u
a bond
H
a bond
NH
S
a bond
Q3a
OH


3283
CMe
NH
Q1u
a bond
H
a bond
NH
S
a bond
Q3b
OH


3284
CMe
NH
Q1u
a bond
H
a bond
NH
S
a bond
Q3c
OH


3285
CMe
NH
Q1u
a bond
H
a bond
NH
O
NH
Q3a
OH


3286
CMe
NH
Q1u
a bond
H
a bond
NH
O
NH
Q3b
OH


3287
CMe
NH
Q1u
a bond
H
a bond
NH
O
NH
Q3c
OH


3288
CMe
NH
Q1u
a bond
H
a bond
NH
O
a bond
Q3a
OH


3289
CMe
NH
Q1u
a bond
H
a bond
NH
O
a bond
Q3b
OH


3290
CMe
NH
Q1u
a bond
H
a bond
NH
O
a bond
Q3c
OH


3291
CMe
NH
Q1v
a bond
Me
a bond
NH
S
NH
Q3a
OH


3292
CMe
NH
Q1v
a bond
Me
a bond
NH
S
NH
Q3b
OH


3293
CMe
NH
Q1v
a bond
Me
a bond
NH
S
NH
Q3c
OH


3294
CMe
NH
Q1v
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3295
CMe
NH
Q1v
a bond
Me
a bond
NH
S
a bond
Q3b
OH


3296
CMe
NH
Q1v
a bond
Me
a bond
NH
S
a bond
Q3c
OH


3297
CMe
NH
Q1v
a bond
Me
a bond
NH
O
NH
Q3a
OH


3298
CMe
NH
Q1v
a bond
Me
a bond
NH
O
NH
Q3b
OH


3299
CMe
NH
Q1v
a bond
Me
a bond
NH
O
NH
Q3c
OH


3300
CMe
NH
Q1v
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3301
CMe
NH
Q1v
a bond
Me
a bond
NH
O
a bond
Q3b
OH


3302
CMe
NH
Q1v
a bond
Me
a bond
NH
O
a bond
Q3c
OH


3303
CMe
NH
Q1v
a bond
H
a bond
NH
S
NH
Q3a
OH


3304
CMe
NH
Q1v
a bond
H
a bond
NH
S
NH
Q3b
OH


3305
CMe
NH
Q1v
a bond
H
a bond
NH
S
NH
Q3c
OH


3306
CMe
NH
Q1v
a bond
H
a bond
NH
S
a bond
Q3a
OH


3307
CMe
NH
Q1v
a bond
H
a bond
NH
S
a bond
Q3b
OH


3308
CMe
NH
Q1v
a bond
H
a bond
NH
S
a bond
Q3c
OH


3309
CMe
NH
Q1v
a bond
H
a bond
NH
O
NH
Q3a
OH


3310
CMe
NH
Q1v
a bond
H
a bond
NH
O
NH
Q3b
OH


3311
CMe
NH
Q1v
a bond
H
a bond
NH
O
NH
Q3c
OH


3312
CMe
NH
Q1v
a bond
H
a bond
NH
O
a bond
Q3a
OH


3313
CMe
NH
Q1v
a bond
H
a bond
NH
O
a bond
Q3b
OH


3314
CMe
NH
Q1v
a bond
H
a bond
NH
O
a bond
Q3c
OH


3315
CMe
NH
Q1w
a bond
Me
a bond
NH
S
NH
Q3a
OH


3316
CMe
NH
Q1w
a bond
Me
a bond
NH
S
NH
Q3b
OH


3317
CMe
NH
Q1w
a bond
Me
a bond
NH
S
NH
Q3c
OH


3318
CMe
NH
Q1w
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3319
CMe
NH
Q1w
a bond
Me
a bond
NH
S
a bond
Q3b
OH


3320
CMe
NH
Q1w
a bond
Me
a bond
NH
S
a bond
Q3c
OH


3321
CMe
NH
Q1w
a bond
Me
a bond
NH
O
NH
Q3a
OH


3322
CMe
NH
Q1w
a bond
Me
a bond
NH
O
NH
Q3b
OH


3323
CMe
NH
Q1w
a bond
Me
a bond
NH
O
NH
Q3c
OH


3324
CMe
NH
Q1w
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3325
CMe
NH
Q1w
a bond
Me
a bond
NH
O
a bond
Q3b
OH


3326
CMe
NH
Q1w
a bond
Me
a bond
NH
O
a bond
Q3c
OH


3327
CMe
NH
Q1w
a bond
H
a bond
NH
S
NH
Q3a
OH


3328
CMe
NH
Q1w
a bond
H
a bond
NH
S
NH
Q3b
OH


3329
CMe
NH
Q1w
a bond
H
a bond
NH
S
NH
Q3c
OH


3330
CMe
NH
Q1w
a bond
H
a bond
NH
S
a bond
Q3a
OH


3331
CMe
NH
Q1w
a bond
H
a bond
NH
S
a bond
Q3b
OH


3332
CMe
NH
Q1w
a bond
H
a bond
NH
S
a bond
Q3c
OH


3333
CMe
NH
Q1w
a bond
H
a bond
NH
O
NH
Q3a
OH


3334
CMe
NH
Q1w
a bond
H
a bond
NH
O
NH
Q3b
OH


3335
CMe
NH
Q1w
a bond
H
a bond
NH
O
NH
Q3c
OH


3336
CMe
NH
Q1w
a bond
H
a bond
NH
O
a bond
Q3a
OH


3337
CMe
NH
Q1w
a bond
H
a bond
NH
O
a bond
Q3b
OH


3338
CMe
NH
Q1w
a bond
H
a bond
NH
O
a bond
Q3c
OH


3339
CMe
NH
Q1x
a bond
Me
a bond
NH
S
NH
Q3a
OH


3340
CMe
NH
Q1x
a bond
Me
a bond
NH
S
NH
Q3b
OH


3341
CMe
NH
Q1x
a bond
Me
a bond
NH
S
NH
Q3c
OH


3342
CMe
NH
Q1x
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3343
CMe
NH
Q1x
a bond
Me
a bond
NH
S
a bond
Q3b
OH


3344
CMe
NH
Q1x
a bond
Me
a bond
NH
S
a bond
Q3c
OH


3345
CMe
NH
Q1x
a bond
Me
a bond
NH
O
NH
Q3a
OH


3346
CMe
NH
Q1x
a bond
Me
a bond
NH
O
NH
Q3b
OH


3347
CMe
NH
Q1x
a bond
Me
a bond
NH
O
NH
Q3c
OH


3348
CMe
NH
Q1x
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3349
CMe
NH
Q1x
a bond
Me
a bond
NH
O
a bond
Q3b
OH


3350
CMe
NH
Q1x
a bond
Me
a bond
NH
O
a bond
Q3c
OH


3351
CMe
NH
Q1x
a bond
H
a bond
NH
S
NH
Q3a
OH


3352
CMe
NH
Q1x
a bond
H
a bond
NH
S
NH
Q3b
OH


3353
CMe
NH
Q1x
a bond
H
a bond
NH
S
NH
Q3c
OH


3354
CMe
NH
Q1x
a bond
H
a bond
NH
S
a bond
Q3a
OH


3355
CMe
NH
Q1x
a bond
H
a bond
NH
S
a bond
Q3b
OH


3356
CMe
NH
Q1x
a bond
H
a bond
NH
S
a bond
Q3c
OH


3357
CMe
NH
Q1x
a bond
H
a bond
NH
O
NH
Q3a
OH


3358
CMe
NH
Q1x
a bond
H
a bond
NH
O
NH
Q3b
OH


3359
CMe
NH
Q1x
a bond
H
a bond
NH
O
NH
Q3c
OH


3360
CMe
NH
Q1x
a bond
H
a bond
NH
O
a bond
Q3a
OH


3361
CMe
NH
Q1x
a bond
H
a bond
NH
O
a bond
Q3b
OH


3362
CMe
NH
Q1x
a bond
H
a bond
NH
O
a bond
Q3c
OH








































































































70) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 3, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. The symbols in Table 3 denote the flowing substituents.


















TABLE 3





No
A
B
R1
L1
R2
L2
L3
Y
L4
R3
X


























1
N
NMe
Q1a
NH
Me
a bond
NH
S
NH
Q3a
OH


2
N
NMe
Q1a
NH
Me
a bond
NH
S
a bond
Q3a
OH


3
N
NMe
Q1a
NH
Me
a bond
NH
O
NH
Q3a
OH


4
N
NMe
Q1a
NH
Me
a bond
NH
O
a bond
Q3a
OH


5
N
NMe
Q1a
NH
H
a bond
NH
S
NH
Q3a
OH


6
N
NMe
Q1a
NH
H
a bond
NH
S
a bond
Q3a
OH


7
N
NMe
Q1a
NH
H
a bond
NH
O
NH
Q3a
OH


8
N
NMe
Q1a
NH
H
a bond
NH
O
a bond
Q3a
OH


9
N
NMe
Q1b
NH
Me
a bond
NH
S
NH
Q3a
OH


10
N
NMe
Q1b
NH
Me
a bond
NH
S
a bond
Q3a
OH


11
N
NMe
Q1b
NH
Me
a bond
NH
O
NH
Q3a
OH


12
N
NMe
Q1b
NH
Me
a bond
NH
O
a bond
Q3a
OH


13
N
NMe
Q1b
NH
H
a bond
NH
S
NH
Q3a
OH


14
N
NMe
Q1b
NH
H
a bond
NH
S
a bond
Q3a
OH


15
N
NMe
Q1b
NH
H
a bond
NH
O
NH
Q3a
OH


16
N
NMe
Q1b
NH
H
a bond
NH
O
a bond
Q3a
OH


17
N
S
Q1a
NH
Me
a bond
NH
S
NH
Q3a
OH


18
N
S
Q1a
NH
Me
a bond
NH
S
a bond
Q3a
OH


19
N
S
Q1a
NH
Me
a bond
NH
O
NH
Q3a
OH


20
N
S
Q1a
NH
Me
a bond
NH
O
a bond
Q3a
OH


21
N
S
Q1a
NH
H
a bond
NH
S
NH
Q3a
OH


22
N
S
Q1a
NH
H
a bond
NH
S
a bond
Q3a
OH


23
N
S
Q1a
NH
H
a bond
NH
O
NH
Q3a
OH


24
N
S
Q1a
NH
H
a bond
NH
O
a bond
Q3a
OH


25
N
S
Q1b
NH
Me
a bond
NH
S
NH
Q3a
OH


26
N
S
Q1b
NH
Me
a bond
NH
S
a bond
Q3a
OH


27
N
S
Q1b
NH
Me
a bond
NH
O
NH
Q3a
OH


28
N
S
Q1b
NH
Me
a bond
NH
O
a bond
Q3a
OH


29
N
S
Q1b
NH
H
a bond
NH
S
NH
Q3a
OH


30
N
S
Q1b
NH
H
a bond
NH
S
a bond
Q3a
OH


31
N
S
Q1b
NH
H
a bond
NH
O
NH
Q3a
OH


32
N
S
Q1b
NH
H
a bond
NH
O
a bond
Q3a
OH


33
N
O
Q1a
NH
Me
a bond
NH
S
NH
Q3a
OH


34
N
O
Q1a
NH
Me
a bond
NH
S
a bond
Q3a
OH


35
N
O
Q1a
NH
Me
a bond
NH
O
NH
Q3a
OH


36
N
O
Q1a
NH
Me
a bond
NH
O
a bond
Q3a
OH


37
N
O
Q1a
NH
H
a bond
NH
S
NH
Q3a
OH


38
N
O
Q1a
NH
H
a bond
NH
S
a bond
Q3a
OH


39
N
O
Q1a
NH
H
a bond
NH
O
NH
Q3a
OH


40
N
O
Q1a
NH
H
a bond
NH
O
a bond
Q3a
OH


41
N
O
Q1b
NH
Me
a bond
NH
S
NH
Q3a
OH


42
N
O
Q1b
NH
Me
a bond
NH
S
a bond
Q3a
OH


43
N
O
Q1b
NH
Me
a bond
NH
O
NH
Q3a
OH


44
N
O
Q1b
NH
Me
a bond
NH
O
a bond
Q3a
OH


45
N
O
Q1b
NH
H
a bond
NH
S
NH
Q3a
OH


46
N
O
Q1b
NH
H
a bond
NH
S
a bond
Q3a
OH


47
N
O
Q1b
NH
H
a bond
NH
O
NH
Q3a
OH


48
N
O
Q1b
NH
H
a bond
NH
O
a bond
Q3a
OH


49
CH
NMe
Q1a
NH
Me
a bond
NH
S
NH
Q3a
OH


50
CH
NMe
Q1a
NH
Me
a bond
NH
S
a bond
Q3a
OH


51
CH
NMe
Q1a
NH
Me
a bond
NH
O
NH
Q3a
OH


52
CH
NMe
Q1a
NH
Me
a bond
NH
O
a bond
Q3a
OH


53
CH
NMe
Q1a
NH
H
a bond
NH
S
NH
Q3a
OH


54
CH
NMe
Q1a
NH
H
a bond
NH
S
a bond
Q3a
OH


55
CH
NMe
Q1a
NH
H
a bond
NH
O
NH
Q3a
OH


56
CH
NMe
Q1a
NH
H
a bond
NH
O
a bond
Q3a
OH


57
CH
NMe
Q1b
NH
Me
a bond
NH
S
NH
Q3a
OH


58
CH
NMe
Q1b
NH
Me
a bond
NH
S
a bond
Q3a
OH


59
CH
NMe
Q1b
NH
Me
a bond
NH
O
NH
Q3a
OH


60
CH
NMe
Q1b
NH
Me
a bond
NH
O
a bond
Q3a
OH


61
CH
NMe
Q1b
NH
H
a bond
NH
S
NH
Q3a
OH


62
CH
NMe
Q1b
NH
H
a bond
NH
S
a bond
Q3a
OH


63
CH
NMe
Q1b
NH
H
a bond
NH
O
NH
Q3a
OH


64
CH
NMe
Q1b
NH
H
a bond
NH
O
a bond
Q3a
OH


65
CH
S
Q1a
NH
Me
a bond
NH
S
NH
Q3a
OH


66
CH
S
Q1a
NH
Me
a bond
NH
S
a bond
Q3a
OH


67
CH
S
Q1a
NH
Me
a bond
NH
O
NH
Q3a
OH


68
CH
S
Q1a
NH
Me
a bond
NH
O
a bond
Q3a
OH


69
CH
S
Q1a
NH
H
a bond
NH
S
NH
Q3a
OH


70
CH
S
Q1a
NH
H
a bond
NH
S
a bond
Q3a
OH


71
CH
S
Q1a
NH
H
a bond
NH
O
NH
Q3a
OH


72
CH
S
Q1a
NH
H
a bond
NH
O
a bond
Q3a
OH


73
CH
S
Q1b
NH
Me
a bond
NH
S
NH
Q3a
OH


74
CH
S
Q1b
NH
Me
a bond
NH
S
a bond
Q3a
OH


75
CH
S
Q1b
NH
Me
a bond
NH
O
NH
Q3a
OH


76
CH
S
Q1b
NH
Me
a bond
NH
O
a bond
Q3a
OH


77
CH
S
Q1b
NH
H
a bond
NH
S
NH
Q3a
OH


78
CH
S
Q1b
NH
H
a bond
NH
S
a bond
Q3a
OH


79
CH
S
Q1b
NH
H
a bond
NH
O
NH
Q3a
OH


80
CH
S
Q1b
NH
H
a bond
NH
O
a bond
Q3a
OH


81
CH
O
Q1a
NH
Me
a bond
NH
S
NH
Q3a
OH


82
CH
O
Q1a
NH
Me
a bond
NH
S
a bond
Q3a
OH


83
CH
O
Q1a
NH
Me
a bond
NH
O
NH
Q3a
OH


84
CH
O
Q1a
NH
Me
a bond
NH
O
a bond
Q3a
OH


85
CH
O
Q1a
NH
H
a bond
NH
S
NH
Q3a
OH


86
CH
O
Q1a
NH
H
a bond
NH
S
a bond
Q3a
OH


87
CH
O
Q1a
NH
H
a bond
NH
O
NH
Q3a
OH


88
CH
O
Q1a
NH
H
a bond
NH
O
a bond
Q3a
OH


89
CH
O
Q1b
NH
Me
a bond
NH
S
NH
Q3a
OH


90
CH
O
Q1b
NH
Me
a bond
NH
S
abond
Q3a
OH


91
CH
O
Q1b
NH
Me
a bond
NH
O
NH
Q3a
OH


92
CH
O
Q1b
NH
Me
a bond
NH
O
a bond
Q3a
OH


93
CH
O
Q1b
NH
H
a bond
NH
S
NH
Q3a
OH


94
CH
O
Q1b
NH
H
a bond
NH
S
a bond
Q3a
OH


95
CH
O
Qib
NH
H
a bond
NH
O
NH
Q3a
OH


96
CH
O
Qib
NH
H
a bond
NH
O
a bond
Q3a
OH


97
CMe
NMe
Q1a
NH
Me
a bond
NH
S
NH
Q3a
OH


98
CMe
NMe
Q1a
NH
Me
a bond
NH
S
a bond
Q3a
OH


99
CMe
NMe
Q1a
NH
Me
a bond
NH
O
NH
Q3a
OH


100
CMe
NMe
Q1a
NH
Me
a bond
NH
O
a bond
Q3a
OH


101
CMe
NMe
Q1a
NH
H
a bond
NH
S
NH
Q3a
OH


102
CMe
NMe
Q1a
NH
H
a bond
NH
S
a bond
Q3a
OH


103
CMe
NMe
Q1a
NH
H
a bond
NH
O
NH
Q3a
OH


104
CMe
NMe
Q1a
NH
H
a bond
NH
O
a bond
Q3a
OH


105
CMe
NMe
Q1b
NH
Me
a bond
NH
S
NH
Q3a
OH


106
CMe
NMe
Q1b
NH
Me
a bond
NH
S
a bond
Q3a
OH


107
CMe
NMe
Q1b
NH
Me
a bond
NH
O
NH
Q3a
OH


108
CMe
NMe
Q1b
NH
Me
a bond
NH
O
a bond
Q3a
OH


109
CMe
NMe
Q1b
NH
H
a bond
NH
S
NH
Q3a
OH


110
CMe
NMe
Q1b
NH
H
a bond
NH
S
a bond
Q3a
OH


111
CMe
NMe
Q1b
NH
H
a bond
NH
O
NH
Q3a
OH


112
CMe
NMe
Q1b
NH
H
a bond
NH
O
a bond
Q3a
OH


113
CMe
S
Q1a
NH
Me
a bond
NH
S
NH
Q3a
OH


114
CMe
S
Q1a
NH
Me
a bond
NH
S
a bond
Q3a
OH


115
CMe
S
Q1a
NH
Me
a bond
NH
O
NH
Q3a
OH


116
CMe
S
Q1a
NH
Me
a bond
NH
O
a bond
Q3a
OH


117
CMe
S
Q1a
NH
H
a bond
NH
S
NH
Q3a
OH


118
CMe
S
Q1a
NH
H
a bond
NH
S
a bond
Q3a
OH


119
CMe
S
Q1a
NH
H
a bond
NH
O
NH
Q3a
OH


120
CMe
S
Q1a
NH
H
a bond
NH
O
a bond
Q3a
OH


121
CMe
S
Q1b
NH
Me
a bond
NH
S
NH
Q3a
OH


122
CMe
S
Q1b
NH
Me
a bond
NH
S
a bond
Q3a
OH


123
CMe
S
Q1b
NH
Me
a bond
NH
O
NH
Q3a
OH


124
CMe
S
Q1b
NH
Me
a bond
NH
O
a bond
Q3a
OH


125
CMe
S
Q1b
NH
H
a bond
NH
S
NH
Q3a
OH


126
CMe
S
Q1b
NH
H
a bond
NH
S
a bond
Q3a
OH


127
CMe
S
Q1b
NH
H
a bond
NH
O
NH
Q3a
OH


128
CMe
S
Q1b
NH
H
a bond
NH
O
a bond
Q3a
OH


129
CMe
O
Q1a
NH
Me
a bond
NH
S
NH
Q3a
OH


130
CMe
O
Q1a
NH
Me
a bond
NH
S
a bond
Q3a
OH


131
CMe
O
Q1a
NH
Me
a bond
NH
O
NH
Q3a
OH


132
CMe
O
Q1a
NH
Me
a bond
NH
O
a bond
Q3a
OH


133
CMe
O
Q1a
NH
H
a bond
NH
S
NH
Q3a
OH


134
CMe
O
Q1a
NH
H
a bond
NH
S
a bond
Q3a
OH


135
CMe
O
Q1a
NH
H
a bond
NH
O
NH
Q3a
OH


136
CMe
O
Q1a
NH
H
a bond
NH
O
a bond
Q3a
OH


137
CMe
O
Q1b
NH
Me
a bond
NH
S
NH
Q3a
OH


138
CMe
O
Q1b
NH
Me
a bond
NH
S
a bond
Q3a
OH


139
CMe
O
Q1b
NH
Me
a bond
NH
O
NH
Q3a
OH


140
CMe
O
Q1b
NH
Me
a bond
NH
O
a bond
Q3a
OH


141
CMe
O
Q1b
NH
H
a bond
NH
S
NH
Q3a
OH


142
CMe
O
Q1b
NH
H
a bond
NH
S
a bond
Q3a
OH


143
CMe
O
Q1b
NH
H
a bond
NH
O
NH
Q3a
OH


144
CMe
O
Q1b
NH
H
a bond
NH
O
a bond
Q3a
OH


145
N
NMe
Q1a
O
Me
a bond
NH
S
NH
Q3a
OH


146
N
NMe
Q1a
O
Me
a bond
NH
S
a bond
Q3a
OH


147
N
NMe
Q1a
O
Me
a bond
NH
O
NH
Q3a
OH


148
N
NMe
Q1a
O
Me
a bond
NH
O
a bond
Q3a
OH


149
N
NMe
Q1a
O
H
a bond
NH
S
NH
Q3a
OH


150
N
NMe
Q1a
O
H
a bond
NH
S
a bond
Q3a
OH


151
N
NMe
Q1a
O
H
a bond
NH
O
NH
Q3a
OH


152
N
NMe
Q1a
O
H
a bond
NH
O
a bond
Q3a
OH


153
N
NMe
Q1b
O
Me
a bond
NH
S
NH
Q3a
OH


154
N
NMe
Q1b
O
Me
a bond
NH
S
a bond
Q3a
OH


155
N
NMe
Q1b
O
Me
a bond
NH
O
NH
Q3a
OH


156
N
NMe
Q1b
O
Me
a bond
NH
O
a bond
Q3a
OH


157
N
NMe
Q1b
O
H
a bond
NH
S
NH
Q3a
OH


158
N
NMe
Q1b
O
H
a bond
NH
S
a bond
Q3a
OH


159
N
NMe
Q1b
O
H
a bond
NH
O
NH
Q3a
OH


160
N
NMe
Q1b
O
H
a bond
NH
O
a bond
Q3a
OH


161
N
S
Q1a
O
Me
a bond
NH
S
NH
Q3a
OH


162
N
S
Q1a
O
Me
a bond
NH
S
a bond
Q3a
OH


163
N
S
Q1a
O
Me
a bond
NH
O
NH
Q3a
OH


164
N
S
Q1a
O
Me
a bond
NH
O
a bond
Q3a
OH


165
N
S
Q1a
O
H
a bond
NH
S
NH
Q3a
OH


166
N
S
Q1a
O
H
a bond
NH
S
a bond
Q3a
OH


167
N
S
Q1a
O
H
a bond
NH
O
NH
Q3a
OH


168
N
S
Q1a
O
H
a bond
NH
O
a bond
Q3a
OH


169
N
S
Q1b
O
Me
a bond
NH
S
NH
Q3a
OH


170
N
S
Q1b
O
Me
a bond
NH
S
a bond
Q3a
OH


171
N
S
Q1b
O
Me
a bond
NH
O
NH
Q3a
OH


172
N
S
Q1b
O
Me
a bond
NH
O
a bond
Q3a
OH


173
N
S
Q1b
O
H
a bond
NH
S
NH
Q3a
OH


174
N
S
Q1b
O
H
a bond
NH
S
a bond
Q3a
OH


175
N
S
Q1b
O
H
a bond
NH
O
NH
Q3a
OH


176
N
S
Q1b
O
H
a bond
NH
O
a bond
Q3a
OH


177
N
O
Q1a
O
Me
a bond
NH
S
NH
Q3a
OH


178
N
O
Q1a
O
Me
a bond
NH
S
a bond
Q3a
OH


179
N
O
Q1a
O
Me
a bond
NH
O
NH
Q3a
OH


180
N
O
Q1a
O
Me
a bond
NH
O
a bond
Q3a
OH


181
N
O
Q1a
O
H
a bond
NH
S
NH
Q3a
OH


182
N
O
Q1a
O
H
a bond
NH
S
a bond
Q3a
OH


183
N
O
Q1a
O
H
a bond
NH
O
NH
Q3a
OH


184
N
O
Q1a
O
H
a bond
NH
O
a bond
Q3a
OH


185
N
O
Q1b
O
Me
a bond
NH
S
NH
Q3a
OH


186
N
O
Q1b
O
Me
a bond
NH
S
a bond
Q3a
OH


187
N
O
Q1b
O
Me
a bond
NH
O
NH
Q3a
OH


188
N
O
Q1b
O
Me
a bond
NH
O
a bond
Q3a
OH


189
N
O
Q1b
O
H
a bond
NH
S
NH
Q3a
OH


190
N
O
Q1b
O
H
a bond
NH
S
a bond
Q3a
OH


191
N
O
Q1b
O
H
a bond
NH
O
NH
Q3a
OH


192
N
O
Q1b
O
H
a bond
NH
O
a bond
Q3a
OH


193
CH
NMe
Q1a
O
Me
a bond
NH
S
NH
Q3a
OH


194
CH
NMe
Q1a
O
Me
a bond
NH
S
a bond
Q3a
OH


195
CH
NMe
Q1a
O
Me
a bond
NH
O
NH
Q3a
OH


196
CH
NMe
Q1a
O
Me
a bond
NH
O
a bond
Q3a
OH


197
CH
NMe
Q1a
O
H
a bond
NH
S
NH
Q3a
OH


198
CH
NMe
Q1a
O
H
a bond
NH
S
a bond
Q3a
OH


199
CH
NMe
Q1a
O
H
a bond
NH
O
NH
Q3a
OH


200
CH
NMe
Q1a
O
H
a bond
NH
O
a bond
Q3a
OH


201
CH
NMe
Q1b
O
Me
a bond
NH
S
NH
Q3a
OH


202
CH
NMe
Q1b
O
Me
a bond
NH
S
a bond
Q3a
OH


203
CH
NMe
Q1b
O
Me
a bond
NH
O
NH
Q3a
OH


204
CH
NMe
Q1b
O
Me
a bond
NH
O
a bond
Q3a
OH


205
CH
NMe
Q1b
O
H
a bond
NH
S
NH
Q3a
OH


206
CH
NMe
Q1b
O
H
a bond
NH
S
a bond
Q3a
OH


207
CH
NMe
Q1b
O
H
a bond
NH
O
NH
Q3a
OH


208
CH
NMe
Q1b
O
H
a bond
NH
O
a bond
Q3a
OH


209
CH
S
Q1a
O
Me
a bond
NH
S
NH
Q3a
OH


210
CH
S
Q1a
O
Me
a bond
NH
S
a bond
Q3a
OH


211
CH
S
Q1a
O
Me
a bond
NH
O
NH
Q3a
OH


212
CH
S
Q1a
O
Me
a bond
NH
O
a bond
Q3a
OH


213
CH
S
Q1a
O
H
a bond
NH
S
NH
Q3a
OH


214
CH
S
Q1a
O
H
a bond
NH
S
a bond
Q3a
OH


215
CH
S
Q1a
O
H
a bond
NH
O
NH
Q3a
OH


216
CH
S
Q1a
O
H
a bond
NH
O
a bond
Q3a
OH


217
CH
S
Q1b
O
Me
a bond
NH
S
NH
Q3a
OH


218
CH
S
Q1b
O
Me
a bond
NH
S
a bond
Q3a
OH


219
CH
S
Q1b
O
Me
a bond
NH
O
NH
Q3a
OH


220
CH
S
Q1b
O
Me
a bond
NH
O
a bond
Q3a
OH


221
CH
S
Q1b
O
H
a bond
NH
S
NH
Q3a
OH


222
CH
S
Q1b
O
H
a bond
NH
S
a bond
Q3a
OH


223
CH
S
Q1b
O
H
a bond
NH
O
NH
Q3a
OH


224
CH
S
Q1b
O
H
a bond
NH
O
a bond
Q3a
OH


225
CH
O
Q1a
O
Me
a bond
NH
S
NH
Q3a
OH


226
CH
O
Q1a
O
Me
a bond
NH
S
a bond
Q3a
OH


227
CH
O
Q1a
O
Me
a bond
NH
O
NH
Q3a
OH


228
CH
O
Q1a
O
Me
a bond
NH
O
a bond
Q3a
OH


229
CH
O
Q1a
O
H
a bond
NH
S
NH
Q3a
OH


230
CH
O
Q1a
O
H
a bond
NH
S
a bond
Q3a
OH


231
CH
O
Q1a
O
H
a bond
NH
O
NH
Q3a
OH


232
CH
O
Q1a
O
H
a bond
NH
O
a bond
Q3a
OH


233
CH
O
Q1b
O
Me
a bond
NH
S
NH
Q3a
OH


234
CH
O
Q1b
O
Me
a bond
NH
S
a bond
Q3a
OH


235
CH
O
Q1b
O
Me
a bond
NH
O
NH
Q3a
OH


236
CH
O
Q1b
O
Me
a bond
NH
O
a bond
Q3a
OH


237
CH
O
Q1b
O
H
a bond
NH
S
NH
Q3a
OH


238
CH
O
Q1b
O
H
a bond
NH
S
a bond
Q3a
OH


239
CH
O
Q1b
O
H
a bond
NH
O
NH
Q3a
OH


240
CH
O
Q1b
O
H
a bond
NH
O
a bond
Q3a
OH


241
CMe
NMe
Q1a
O
Me
a bond
NH
S
NH
Q3a
OH


242
CMe
NMe
Q1a
O
Me
a bond
NH
S
a bond
Q3a
OH


243
CMe
NMe
Q1a
O
Me
a bond
NH
O
NH
Q3a
OH


244
CMe
NMe
Q1a
O
Me
a bond
NH
O
a bond
Q3a
OH


245
CMe
NMe
Q1a
O
H
a bond
NH
S
NH
Q3a
OH


246
CMe
NMe
Q1a
O
H
a bond
NH
S
a bond
Q3a
OH


247
CMe
NMe
Q1a
O
H
a bond
NH
O
NH
Q3a
OH


248
CMe
NMe
Q1a
O
H
a bond
NH
O
a bond
Q3a
OH


249
CMe
NMe
Q1b
O
Me
a bond
NH
S
NH
Q3a
OH


250
CMe
NMe
Q1b
O
Me
a bond
NH
S
a bond
Q3a
OH


251
CMe
NMe
Q1b
O
Me
a bond
NH
O
NH
Q3a
OH


252
CMe
NMe
Q1b
O
Me
a bond
NH
O
a bond
Q3a
OH


253
CMe
NMe
Q1b
O
H
a bond
NH
S
NH
Q3a
OH


254
CMe
NMe
Q1b
O
H
a bond
NH
S
a bond
Q3a
OH


255
CMe
NMe
Q1b
O
H
a bond
NH
O
NH
Q3a
OH


256
CMe
NMe
Q1b
O
H
a bond
NH
O
a bond
Q3a
OH


257
CMe
S
Q1a
O
Me
a bond
NH
S
NH
Q3a
OH


258
CMe
S
Q1a
O
Me
a bond
NH
S
a bond
Q3a
OH


259
CMe
S
Q1a
O
Me
a bond
NH
O
NH
Q3a
OH


260
CMe
S
Q1a
O
Me
a bond
NH
O
a bond
Q3a
OH


261
CMe
S
Q1a
O
H
a bond
NH
S
NH
Q3a
OH


262
CMe
S
Q1a
O
H
a bond
NH
S
a bond
Q3a
OH


263
CMe
S
Q1a
O
H
a bond
NH
O
NH
Q3a
OH


264
CMe
S
Q1a
O
H
a bond
NH
O
a bond
Q3a
OH


265
CMe
S
Q1b
O
Me
a bond
NH
S
NH
Q3a
OH


266
CMe
S
Q1b
O
Me
a bond
NH
S
a bond
Q3a
OH


267
CMe
S
Q1b
O
Me
a bond
NH
O
NH
Q3a
OH


268
CMe
S
Q1b
O
Me
a bond
NH
O
a bond
Q3a
OH


269
CMe
S
Q1b
O
H
a bond
NH
S
NH
Q3a
OH


270
CMe
S
Q1b
O
H
a bond
NH
S
a bond
Q3a
OH


271
CMe
S
Q1b
O
H
a bond
NH
O
NH
Q3a
OH


272
CMe
S
Q1b
O
H
a bond
NH
O
a bond
Q3a
OH


273
CMe
O
Q1a
O
Me
a bond
NH
S
NH
Q3a
OH


274
CMe
O
Q1a
O
Me
a bond
NH
S
a bond
Q3a
OH


275
CMe
O
Q1a
O
Me
a bond
NH
O
NH
Q3a
OH


276
CMe
O
Q1a
O
Me
a bond
NH
O
a bond
Q3a
OH


277
CMe
O
Q1a
O
H
a bond
NH
S
NH
Q3a
OH


278
CMe
O
Q1a
O
H
a bond
NH
S
a bond
Q3a
OH


279
CMe
O
Q1a
O
H
a bond
NH
O
NH
Q3a
OH


280
CMe
O
Q1a
O
H
a bond
NH
O
a bond
Q3a
OH


281
CMe
O
Q1b
O
Me
a bond
NH
S
NH
Q3a
OH


282
CMe
O
Q1b
O
Me
a bond
NH
S
a bond
Q3a
OH


283
CMe
O
Q1b
O
Me
a bond
NH
O
NH
Q3a
OH


284
CMe
O
Q1b
O
Me
a bond
NH
O
a bond
Q3a
OH


285
CMe
O
Q1b
O
H
a bond
NH
S
NH
Q3a
OH


286
CMe
O
Q1b
O
H
a bond
NH
S
a bond
Q3a
OH


287
CMe
O
Q1b
O
H
a bond
NH
O
NH
Q3a
OH


288
CMe
O
Q1b
O
H
a bond
NH
O
a bond
Q3a
OH


289
N
NMe
Q1a
CH2
Me
a bond
NH
S
NH
Q3a
OH


290
N
NMe
Q1a
CH2
Me
a bond
NH
S
a bond
Q3a
OH


291
N
NMe
Q1a
CH2
Me
a bond
NH
O
NH
Q3a
OH


292
N
NMe
Q1a
CH2
Me
a bond
NH
O
a bond
Q3a
OH


293
N
NMe
Q1a
CH2
H
a bond
NH
S
NH
Q3a
OH


294
N
NMe
Q1a
CH2
H
a bond
NH
S
a bond
Q3a
OH


295
N
NMe
Q1a
CH2
H
a bond
NH
O
NH
Q3a
OH


296
N
NMe
Q1a
CH2
H
a bond
NH
O
a bond
Q3a
OH


297
N
NMe
Q1b
CH2
Me
a bond
NH
S
NH
Q3a
OH


298
N
NMe
Q1b
CH2
Me
a bond
NH
S
a bond
Q3a
OH


299
N
NMe
Q1b
CH2
Me
a bond
NH
O
NH
Q3a
OH


300
N
NMe
Q1b
CH2
Me
a bond
NH
O
a bond
Q3a
OH


301
N
NMe
Q1b
CH2
H
a bond
NH
S
NH
Q3a
OH


302
N
NMe
Q1b
CH2
H
a bond
NH
S
a bond
Q3a
OH


303
N
NMe
Q1b
CH2
H
a bond
NH
O
NH
Q3a
OH


304
N
NMe
Q1b
CH2
H
a bond
NH
O
a bond
Q3a
OH


305
N
S
Q1a
CH2
Me
a bond
NH
S
NH
Q3a
OH


306
N
S
Q1a
CH2
Me
a bond
NH
S
a bond
Q3a
OH


307
N
S
Q1a
CH2
Me
a bond
NH
O
NH
Q3a
OH


308
N
S
Q1a
CH2
Me
a bond
NH
O
a bond
Q3a
OH


309
N
S
Q1a
CH2
H
a bond
NH
S
NH
Q3a
OH


310
N
S
Q1a
CH2
H
a bond
NH
S
a bond
Q3a
OH


311
N
S
Q1a
CH2
H
a bond
NH
O
NH
Q3a
OH


312
N
S
Q1a
CH2
H
a bond
NH
O
a bond
Q3a
OH


313
N
S
Q1b
CH2
Me
a bond
NH
S
NH
Q3a
OH


314
N
S
Q1b
CH2
Me
a bond
NH
S
a bond
Q3a
OH


315
N
S
Q1b
CH2
Me
a bond
NH
O
NH
Q3a
OH


316
N
S
Q1b
CH2
Me
a bond
NH
O
a bond
Q3a
OH


317
N
S
Q1b
CH2
H
a bond
NH
S
NH
Q3a
OH


318
N
S
Q1b
CH2
H
a bond
NH
S
a bond
Q3a
OH


319
N
S
Q1b
CH2
H
a bond
NH
O
NH
Q3a
OH


320
N
S
Q1b
CH2
H
a bond
NH
O
a bond
Q3a
OH


321
N
O
Q1a
CH2
Me
a bond
NH
S
NH
Q3a
OH


322
N
O
Q1a
CH2
Me
a bond
NH
S
a bond
Q3a
OH


323
N
O
Q1a
CH2
Me
a bond
NH
O
NH
Q3a
OH


324
N
O
Q1a
CH2
Me
a bond
NH
O
a bond
Q3a
OH


325
N
O
Q1a
CH2
H
a bond
NH
S
NH
Q3a
OH


326
N
O
Q1a
CH2
H
a bond
NH
S
a bond
Q3a
OH


327
N
O
Q1a
CH2
H
a bond
NH
O
NH
Q3a
OH


328
N
O
Q1a
CH2
H
a bond
NH
O
a bond
Q3a
OH


329
N
O
Q1b
CH2
Me
a bond
NH
S
NH
Q3a
OH


330
N
O
Q1b
CH2
Me
a bond
NH
S
a bond
Q3a
OH


331
N
O
Q1b
CH2
Me
a bond
NH
O
NH
Q3a
OH


332
N
O
Q1b
CH2
Me
a bond
NH
O
a bond
Q3a
OH


333
N
O
Q1b
CH2
H
a bond
NH
S
NH
Q3a
OH


334
N
O
Q1b
CH2
H
a bond
NH
S
a bond
Q3a
OH


335
N
O
Q1b
CH2
H
a bond
NH
O
NH
Q3a
OH


336
N
O
Q1b
CH2
H
a bond
NH
O
a bond
Q3a
OH


337
CH
NMe
Q1a
CH2
Me
a bond
NH
S
NH
Q3a
OH


338
CH
NMe
Q1a
CH2
Me
a bond
NH
S
a bond
Q3a
OH


339
CH
NMe
Q1a
CH2
Me
a bond
NH
O
NH
Q3
OH


340
CH
NMe
Q1a
CH2
Me
a bond
NH
O
a bond
Q3a
OH


341
CH
NMe
Q1a
CH2
H
a bond
NH
S
NH
Q3a
OH


342
CH
NMe
Q1a
CH2
H
a bond
NH
S
a bond
Q3a
OH


343
CH
NMe
Q1a
CH2
H
a bond
NH
O
NH
Q3a
OH


344
CH
NMe
Q1a
CH2
H
a bond
NH
O
a bond
3aOH


345
CH
NMe
Q1b
CH2
Me
a bond
NH
S
NH
Q3a
OH


346
CH
NMe
Q1b
CH2
Me
a bond
NH
S
a bond
Q3a
OH


347
CH
NMe
Q1b
CH2
Me
a bond
NH
O
NH
Q3a
OH


348
CH
NMe
Q1b
CH2
Me
a bond
NH
O
a bond
Q3a
OH


349
CH
NMe
Q1b
CH2
H
a bond
NH
S
NH
Q3a
OH


350
CH
NMe
Q1b
CH2
H
a bond
NH
S
a bond
Q3a
OH


351
CH
NNe
Q1b
CH2
H
a bond
NH
O
NH
Q3a
OH


352
CH
NMe
Q1b
CH2
H
a bond
NH
O
a bond
Q3a
OH


353
CH
S
Q1a
CH2
Me
a bond
NH
S
NH
Q3a
OH


354
CH
S
Q1a
CH2
Me
a bond
NH
S
a bond
Q3a
OH


355
CH
S
Q1a
CH2
Me
a bond
NH
O
NH
Q3a
OH


356
CH
S
Q1a
CH2
Me
a bond
NH
O
a bond
Q3a
OH


357
CH
S
Q1a
CH2
H
a bond
NH
S
NH
Q3a
OH


358
CH
S
Q1a
CH2
H
a bond
NH
S
a bond
Q3a
OH


359
CH
S
Q1a
CH2
H
a bond
NH
O
NH
Q3a
OH


360
CH
S
Q1a
CH2
H
a bond
NH
O
a bond
Q3a
OH


361
CH
S
Q1b
CH2
Me
a bond
NH
S
NH
Q3a
OH


362
CH
S
Q1b
CH2
Me
a bond
NH
S
a bond
Q3a
OH


363
CH
S
Q1b
CH2
Me
a bond
NH
O
NH
Q3a
OH


364
CH
S
Q1b
CH2
Me
a bond
NH
O
a bond
Q3a
OH


365
CH
S
Q1b
CH2
H
a bond
NH
S
NH
Q3a
OH


366
CH
S
Q1b
CH2
H
a bond
NH
S
a bond
Q3a
OH


367
CH
S
Q1b
CH2
H
a bond
NH
O
NH
Q3a
OH


368
CH
S
Q1b
CH2
H
a bond
NH
O
a bond
Q3a
OH


369
CH
O
Q1a
CH2
Me
a bond
NH
S
NH
Q3a
OH


370
CH
O
Q1a
CH2
Me
a bond
NH
S
a bond
Q3a
OH


371
CH
O
Q1a
CH2
Me
a bond
NH
O
NH
Q3a
OH


372
CH
O
Q1a
CH2
Me
a bond
NH
O
a bond
Q3a
OH


373
CH
O
Q1a
CH2
H
a bond
NH
S
NH
Q3a
OH


374
CH
O
Q1a
CH2
H
a bond
NH
S
a bond
Q3a
OH


375
CH
O
Q1a
CH2
H
a bond
NH
O
NH
Q3a
OH


376
CH
O
Q1a
CH2
H
a bond
NH
O
a bond
Q3a
OH


377
CH
O
Q1b
CH2
Me
a bond
NH
S
NH
Q3a
OH


378
CH
O
Q1b
CH2
Me
a bond
NH
S
a bond
Q3a
OH


379
CH
O
Q1b
CH2
Me
a bond
NH
O
NH
Q3a
OH


380
CH
O
Q1b
CH2
Me
a bond
NH
O
a bond
Q3a
OH


381
CH
O
Q1b
CH2
H
a bond
NH
S
NH
Q3a
OH


382
CH
O
Q1b
CH2
H
a bond
NH
S
a bond
Q3a
OH


383
CH
O
Q1b
CH2
H
a bond
NH
O
NH
Q3a
OH


384
CH
O
Q1b
CH2
H
a bond
NH
O
a bond
Q3a
OH


385
CMe
NMe
Q1a
CH2
Me
a bond
NH
S
NH
Q3a
OH


386
CMe
NMe
Q1a
CH2
Me
a bond
NH
S
a bond
Q3a
OH


387
CMe
NMe
Q1a
CH2
Me
a bond
NH
O
NH
Q3a
OH


388
CMe
NMe
Q1a
CH2
Me
a bond
NH
O
a bond
Q3a
OH


389
CMe
NMe
Q1a
CH2
H
a bond
NH
S
NH
Q3a
OH


390
CMe
NMe
Q1a
CH2
H
a bond
NH
S
a bond
Q3a
OH


391
CMe
NMe
Q1a
CH2
H
a bond
NH
O
NH
Q3a
OH


392
CMe
NMe
Q1a
CH2
H
a bond
NH
O
a bond
Q3a
OH


393
CMe
NMe
Q1b
CH2
Me
a bond
NH
S
NH
Q3a
OH


394
CMe
NMe
Q1b
CH2
Me
a bond
NH
S
a bond
Q3a
OH


395
CMe
NMe
Q1b
CH2
Me
a bond
NH
O
NH
Q3a
OH


396
CMe
NMe
Q1b
CH2
Me
a bond
NH
O
a bond
Q3a
OH


397
CMe
NMe
Q1b
CH2
H
a bond
NH
S
NH
Q3a
OH


398
CMe
NMe
Q1b
CH2
H
a bond
NH
S
a bond
Q3a
OH


399
CMe
NMe
Q1b
CH2
H
a bond
NH
O
NH
Q3a
OH


400
CMe
NMe
Q1b
CH2
H
a bond
NH
O
a bond
Q3a
OH


401
CMe
S
Q1a
CH2
Me
a bond
NH
S
NH
Q3a
OH


402
CMe
S
Q1a
CH2
Me
a bond
NH
S
a bond
Q3a
OH


403
CMe
S
Q1a
CH2
Me
a bond
NH
O
NH
Q3a
OH


404
CMe
S
Q1a
CH2
Me
a bond
NH
O
a bond
Q3a
OH


405
CMe
S
Q1a
CH2
H
a bond
NH
S
NH
Q3a
OH


406
CMe
S
Q1a
CH2
H
a bond
NH
S
a bond
Q3a
OH


407
CMe
S
Q1a
CH2
H
a bond
NH
O
NH
Q3a
OH


408
CMe
S
Q1a
CH2
H
a bond
NH
O
a bond
Q3a
OH


409
CMe
S
Q1b
CH2
Me
a bond
NH
S
NH
Q3a
OH


410
CMe
S
Q1b
CH2
Me
a bond
NH
S
a bond
Q3a
OH


411
CMe
S
Q1b
CH2
Me
a bond
NH
O
NH
Q3a
OH


412
CMe
S
Q1b
CH2
Me
a bond
NH
O
a bond
Q3a
OH


413
CMe
S
Q1b
CH2
H
a bond
NH
S
NH
Q3a
OH


414
CMe
S
Q1b
CH2
H
a bond
NH
S
a bond
Q3a
OH


415
CMe
S
Q1b
CH2
H
a bond
NH
O
NH
Q3a
OH


416
CMe
S
Q1b
CH2
H
a bond
NH
O
a bond
Q3a
OH


417
CMe
O
Q1a
CH2
Me
a bond
NH
S
NH
Q3a
OH


418
CMe
O
Q1a
CH2
Me
a bond
NH
S
a bond
Q3a
OH


419
CMe
O
Q1a
CH2
Me
a bond
NH
O
NH
Q3a
OH


420
CMe
O
Q1a
CH2
Me
a bond
NH
O
a bond
Q3a
OH


421
CMe
O
Q1a
CH2
H
a bond
NH
S
NH
Q3a
OH


422
CMe
O
Q1a
CH2
H
a bond
NH
S
a bond
Q3a
OH


423
CMe
O
Q1a
CH2
H
a bond
NH
O
NH
Q3a
OH


424
CMe
O
Q1a
CH2
H
a bond
NH
O
a bond
Q3a
OH


425
CMe
O
Q1b
CH2
Me
a bond
NH
S
NH
Q3a
OH


426
CMe
O
Q1b
CH2
Me
a bond
NH
S
a bond
Q3a
OH


427
CMe
O
Q1b
CH2
Me
a bond
NH
O
NH
Q3a
OH


428
CMe
O
Q1b
CH2
Me
a bond
NH
O
a bond
Q3a
OH


429
CMe
O
Q1b
CH2
H
a bond
NH
S
NH
Q3a
OH


430
CMe
O
Q1b
CH2
H
a bond
NH
S
a bond
Q3a
OH


431
CMe
O
Q1b
CH2
H
a bond
NH
O
NH
Q3a
OH


432
CMe
O
Q1b
CH2
H
a bond
NH
O
a bond
Q3a
OH


433
N
NMe
Q1a
a bond
Me
a bond
NH
S
CH2
Q3a
OH


434
N
NMe
Q1a
a bond
Me
a bond
NH
O
CH2
Q3a
OH


435
N
NMe
Q1a
a bond
H
a bond
NH
S
CH2
Q3a
OH


436
N
NMe
Q1a
a bond
H
a bond
NH
O
CH2
Q3a
OH


437
N
NMe
Q1b
a bond
Me
a bond
NH
S
CH2
Q3a
OH


438
N
NMe
Q1b
a bond
Me
a bond
NH
O
CH2
Q3a
OH


439
N
NMe
Q1b
a bond
H
a bond
NH
S
CH2
Q3a
OH


440
N
NMe
Q1b
a bond
H
a bond
NH
O
CH2
Q3a
OH


441
N
S
Q1a
a bond
Me
a bond
NH
S
CH2
Q3a
OH


442
N
S
Q1a
a bond
Me
a bond
NH
O
CH2
Q3a
OH


443
N
S
Q1a
a bond
H
a bond
NH
S
CH2
Q3a
OH


444
N
S
Q1a
a bond
H
a bond
NH
O
CH2
Q3a
OH


445
N
S
Q1b
a bond
Me
a bond
NH
S
CH2
Q3a
OH


446
N
S
Q1b
a bond
Me
a bond
NH
O
CH2
Q3a
OH


447
N
S
Q1b
a bond
H
a bond
NH
S
CH2
Q3a
OH


448
N
S
Q1b
a bond
H
a bond
NH
O
CH2
Q3a
OH


449
N
O
Q1a
a bond
Me
a bond
NH
S
CH2
Q3a
OH


450
N
O
Q1a
a bond
Me
a bond
NH
O
CH2
Q3a
OH


451
N
O
Q1a
a bond
H
a bond
NH
S
CH2
Q3a
OH


452
N
O
Q1a
a bond
H
a bond
NH
O
CH2
Q3a
OH


453
N
O
Q1b
a bond
Me
a bond
NH
S
CH2
Q3a
OH


454
N
O
Q1b
a bond
Me
a bond
NH
O
CH2
Q3a
OH


455
N
O
Q1b
a bond
H
a bond
NH
S
CH2
Q3a
OH


456
N
O
Q1b
a bond
H
a bond
NH
O
CH2
Q3a
OH


457
CH
NMe
Q1a
a bond
Me
a bond
NH
S
CH2
Q3a
OH


458
CH
NMe
Q1a
a bond
Me
a bond
NH
O
CH2
Q3a
OH


459
CH
NMe
Q1a
a bond
H
a bond
NH
S
CH2
Q3a
OH


460
CH
NMe
Q1a
a bond
H
a bond
NH
O
CH2
Q3a
OH


461
CH
NMe
Q1b
a bond
Me
a bond
NH
S
CH2
Q3a
OH


462
CH
NMe
Q1b
a bond
Me
a bond
NH
O
CH2
Q3a
OH


463
CH
NMe
Q1b
a bond
H
a bond
NH
S
CH2
Q3a
OH


464
CH
NMe
Q1b
a bond
H
a bond
NH
O
CH2
Q3a
OH


465
CH
S
Q1a
a bond
Me
a bond
NH
S
CH2
Q3a
OH


466
CH
S
Q1a
a bond
Me
a bond
NH
O
CH2
Q3a
OH


467
CH
S
Q1a
a bond
H
a bond
NH
S
CH2
Q3a
OH


468
CH
S
Q1a
a bond
H
a bond
NH
O
CH2
Q3a
OH


469
CH
S
Q1b
a bond
Me
a bond
NH
S
CH2
Q3a
OH


470
CH
S
Q1b
a bond
Me
a bond
NH
O
CH2
Q3a
OH


471
CH
S
Q1b
a bond
H
a bond
NH
S
CH2
Q3a
OH


472
CH
S
Q1b
a bond
H
a bond
NH
O
CH2
Q3a
OH


473
CH
O
Q1a
a bond
Me
a bond
NH
S
CH2
Q3a
OH


474
CH
O
Q1a
a bond
Me
a bond
NH
O
CH2
Q3a
OH


475
CH
O
Q1a
a bond
H
a bond
NH
S
CH2
Q3a
OH


476
CH
O
Q1a
a bond
H
a bond
NH
O
CH2
Q3a
OH


477
CH
O
Q1b
a bond
Me
a bond
NH
S
CH2
Q3a
OH


478
CH
O
Q1b
a bond
Me
a bond
NH
O
CH2
Q3a
OH


479
CH
O
Q1b
a bond
H
a bond
NH
S
CH2
Q3a
OH


480
CH
O
Q1b
a bond
H
a bond
NH
O
CH2
Q3a
OH


481
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
CH2
Q3a
OH


482
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
CH2
Q3a
OH


483
CMe
NMe
Q1a
a bond
H
a bond
NH
S
CH2
Q3a
OH


484
CMe
NMe
Q1a
a bond
H
a bond
NH
O
CH2
Q3a
OH


485
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
CH2
Q3a
OH


486
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
CH2
Q3a
OH


487
CMe
NMe
Q1b
a bond
H
a bond
NH
S
CH2
Q3a
OH


488
CMe
NMe
Q1b
a bond
H
a bond
NH
O
CH2
Q3a
OH


489
CMe
S
Q1a
a bond
Me
a bond
NH
S
CH2
Q3a
OH


490
CMe
S
Q1a
a bond
Me
a bond
NH
O
CH2
Q3a
OH


491
CMe
S
Q1a
a bond
H
a bond
NH
S
CH2
Q3a
OH


492
CMe
S
Q1a
a bond
H
a bond
NH
O
CH2
Q3a
OH


493
CMe
S
Q1b
a bond
Me
a bond
NH
S
CH2
Q3a
OH


494
CMe
S
Q1b
a bond
Me
a bond
NH
O
CH2
Q3a
OH


495
CMe
S
Q1b
a bond
H
a bond
NH
S
CH2
Q3a
OH


496
CMe
S
Q1b
a bond
H
a bond
NH
O
CH2
Q3a
OH


497
CMe
O
Q1a
a bond
Me
a bond
NH
S
CH2
Q3a
OH


498
CMe
O
Q1a
a bond
Me
a bond
NH
O
CH2
Q3a
OH


499
CMe
O
Q1a
a bond
H
a bond
NH
S
CH2
Q3a
OH


500
CMe
O
Q1a
a bond
H
a bond
NH
O
CH2
Q3a
OH


501
CMe
O
Q1b
a bond
Me
a bond
NH
S
CH2
Q3a
OH


502
CMe
O
Q1b
a bond
Me
a bond
NH
O
CH2
Q3a
OH


503
CMe
O
Q1b
a bond
H
a bond
NH
S
CH2
Q3a
OH


504
CMe
O
Q1b
a bond
H
a bond
NH
O
CH2
Q3a
OH


505
N
NMe
Q1a
a bond
Me
a bond
CH2
S
a bond
Q3a
OH


506
N
NMe
Q1a
a bond
Me
a bond
CH2
S
NH
Q3a
OH


507
N
NMe
Q1a
a bond
Me
a bond
CH2
O
a bond
Q3a
OH


508
N
NMe
Q1a
a bond
Me
a bond
CH2
O
NH
Q3a
OH


509
N
NMe
Q1a
a bond
H
a bond
CH2
S
a bond
Q3a
OH


510
N
NMe
Q1a
a bond
H
a bond
CH2
S
NH
Q3a
OH


511
N
NMe
Q1a
a bond
H
a bond
CH2
O
a bond
Q3a
OH


512
N
NMe
Q1a
a bond
H
a bond
CH2
O
NH
Q3a
OH


513
N
NMe
Q1b
a bond
Me
a bond
CH2
S
a bond
Q3a
OH


514
N
NMe
Q1b
a bond
Me
a bond
CH2
S
NH
Q3a
OH


515
N
NMe
Q1b
a bond
Me
a bond
CH2
O
a bond
Q3a
OH


516
N
NMe
Q1b
a bond
Me
a bond
CH2
O
NH
Q3a
OH


517
N
NMe
Q1b
a bond
H
a bond
CH2
S
a bond
Q3a
OH


518
N
NMe
Q1b
a bond
H
a bond
CH2
S
NH
Q3a
OH


519
N
NMe
Q1b
a bond
H
a bond
CH2
O
a bond
Q3a
OH


520
N
NMe
Q1b
a bond
H
a bond
CH2
O
NH
Q3a
OH


521
N
S
Q1a
a bond
Me
a bond
CH2
S
a bond
Q3a
OH


522
N
S
Q1a
a bond
Me
a bond
CH2
S
NH
Q3a
OH


523
N
S
Q1a
a bond
Me
a bond
CH2
O
a bond
Q3a
OH


524
N
S
Q1a
a bond
Me
a bond
CH2
O
NH
Q3a
OH


525
N
S
Q1a
a bond
H
a bond
CH2
S
a bond
Q3a
OH


526
N
S
Q1a
a bond
H
a bond
CH2
S
NH
Q3a
OH


527
N
S
Q1a
a bond
H
a bond
CH2
O
a bond
Q3a
OH


528
N
S
Q1a
a bond
H
a bond
CH2
O
NH
Q3a
OH


529
N
S
Q1b
a bond
Me
a bond
CH2
S
a bond
Q3a
OH


530
N
S
Q1b
a bond
Me
a bond
CH2
S
NH
Q3a
OH


531
N
S
Q1b
a bond
Me
a bond
CH2
O
a bond
Q3a
OH


532
N
S
Q1b
a bond
Me
a bond
CH2
O
NH
Q3a
OH


533
N
S
Q1b
a bond
H
a bond
CH2
S
a bond
Q3a
OH


534
N
S
Q1b
a bond
H
a bond
CH2
S
NH
Q3a
OH


535
N
S
Q1b
a bond
H
a bond
CH2
O
a bond
Q3a
OH


536
N
S
Q1b
a bond
H
a bond
CH2
O
NH
Q3a
OH


537
N
O
Q1a
a bond
Me
a bond
CH2
S
a bond
Q3a
OH


538
N
O
Q1a
a bond
Me
a bond
CH2
S
NH
Q3a
OH


539
N
O
Q1a
a bond
Me
a bond
CH2
O
a bond
Q3a
OH


540
N
O
Q1a
a bond
Me
a bond
CH2
O
NH
Q3a
OH


541
N
O
Q1a
a bond
H
a bond
CH2
S
a bond
Q3a
OH


542
N
O
Q1a
a bond
H
a bond
CH2
S
NH
Q3a
OH


543
N
O
Q1a
a bond
H
a bond
CH2
O
a bond
Q3a
OH


544
N
O
Q1a
a bond
H
a bond
CH2
O
NH
Q3a
OH


545
N
O
Q1b
a bond
Me
a bond
CH2
S
a bond
Q3a
OH


546
N
O
Q1b
a bond
Me
a bond
CH2
S
NH
Q3a
OH


547
N
O
Q1b
a bond
Me
a bond
CH2
O
a bond
Q3a
OH


548
N
O
Q1b
a bond
Me
a bond
CH2
O
NH
Q3a
OH


549
N
O
Q1b
a bond
H
a bond
CH2
S
a bond
Q3a
OH


550
N
O
Q1b
a bond
H
a bond
CH2
S
NH
Q3a
OH


551
N
O
Q1b
a bond
H
a bond
CH2
O
a bond
Q3a
OH


552
N
O
Q1b
a bond
H
a bond
CH2
O
NH
Q3a
OH


553
CH
NMe
Q1a
a bond
Me
a bond
CH2
S
a bond
Q3a
OH


554
CH
NMe
Q1a
a bond
Me
a bond
CH2
S
NH
Q3a
OH


555
CH
NMe
Q1a
a bond
Me
a bond
CH2
O
a bond
Q3a
OH


556
CH
NMe
Q1a
a bond
Me
a bond
CH2
O
NH
Q3a
OH


557
CH
NMe
Q1a
a bond
H
a bond
CH2
S
a bond
Q3a
OH


558
CH
NMe
Q1a
a bond
H
a bond
CH2
S
NH
Q3a
OH


559
CH
NMe
Q1a
a bond
H
a bond
CH2
O
a bond
Q3a
OH


560
CH
NMe
Q1a
a bond
H
a bond
CH2
O
NH
Q3a
OH


561
CH
NMe
Q1b
a bond
Me
a bond
CH2
S
a bond
Q3a
OH


562
CH
NMe
Q1b
a bond
Me
a bond
CH2
S
NH
Q3a
OH


563
CH
NMe
Q1b
a bond
Me
a bond
CH2
O
a bond
Q3a
OH


564
CH
NMe
Q1b
a bond
Me
a bond
CH2
O
NH
Q3a
OH


565
CH
NMe
Q1b
a bond
H
a bond
CH2
S
a bond
Q3a
OH


566
CH
NMe
Q1b
a bond
H
a bond
CH2
S
NH
Q3a
OH


567
CH
NMe
Q1b
a bond
H
a bond
CH2
O
a bond
Q3a
OH


568
CH
NMe
Q1b
a bond
H
a bond
CH2
O
NH
Q3a
OH


569
CH
S
Q1a
a bond
Me
a bond
CH2
S
a bond
Q3a
OH


570
CH
S
Q1a
a bond
Me
a bond
CH2
S
NH
Q3a
OH


571
CH
S
Q1a
a bond
Me
a bond
CH2
O
a bond
Q3a
OH


572
CH
S
Q1a
a bond
Me
a bond
CH2
O
NH
Q3a
OH


573
CH
S
Q1a
a bond
H
a bond
CH2
S
a bond
Q3a
OH


574
CH
S
Q1a
a bond
H
a bond
CH2
S
NH
Q3a
OH


575
CH
S
Q1a
a bond
H
a bond
CH2
O
a bond
Q3a
OH


576
CH
S
Q1a
a bond
H
a bond
CH2
O
NH
Q3a
OH


577
CH
S
Q1b
a bond
Me
a bond
CH2
S
a bond
Q3a
OH


578
CH
S
Q1b
a bond
Me
a bond
CH2
S
NH
Q3a
OH


579
CH
S
Q1b
a bond
Me
a bond
CH2
O
a bond
Q3a
OH


580
CH
S
Q1b
a bond
Me
a bond
CH2
O
NH
Q3a
OH


581
CH
S
Q1b
a bond
H
a bond
CH2
S
a bond
Q3a
OH


582
CH
S
Q1b
a bond
H
a bond
CH2
S
NH
Q3a
OH


583
CH
S
Q1b
a bond
H
a bond
CH2
O
a bond
Q3a
OH


584
CH
S
Q1b
a bond
H
a bond
CH2
O
NH
Q3a
OH


585
CH
O
Q1a
a bond
Me
a bond
CH2
S
a bond
Q3a
OH


586
CH
O
Q1a
a bond
Me
a bond
CH2
S
NH
Q3a
OH


587
CH
O
Q1a
a bond
Me
a bond
CH2
O
a bond
Q3a
OH


588
CH
O
Q1a
a bond
Me
a bond
CH2
O
NH
Q3a
OH


589
CH
O
Q1a
a bond
H
a bond
CH2
S
a bond
Q3a
OH


590
CH
O
Q1a
a bond
H
a bond
CH2
S
NH
Q3a
OH


591
CH
O
Q1a
a bond
H
a bond
CH2
O
a bond
Q3a
OH


592
CH
O
Q1a
a bond
H
a bond
CH2
O
NH
Q3a
OH


593
CH
O
Q1b
a bond
Me
a bond
CH2
S
a bond
Q3a
OH


594
CH
O
Q1b
a bond
Me
a bond
CH2
S
NH
Q3a
OH


595
CH
O
Q1b
a bond
Me
a bond
CH2
O
a bond
Q3a
OH


596
CH
O
Q1b
a bond
Me
a bond
CH2
O
NH
Q3a
OH


597
CH
O
Q1b
a bond
H
a bond
CH2
S
a bond
Q3a
OH


598
CH
O
Q1b
a bond
H
a bond
CH2
S
NH
Q3a
OH


599
CH
O
Q1b
a bond
H
a bond
CH2
O
a bond
Q3a
OH


600
CH
O
Q1b
a bond
H
a bond
CH2
O
NH
Q3a
OH


601
CMe
NMe
Q1a
a bond
Me
a bond
CH2
S
a bond
Q3a
OH


602
CMe
NMe
Q1a
a bond
Me
a bond
CH2
S
NH
Q3a
OH


603
CMe
NMe
Q1a
a bond
Me
a bond
CH2
O
a bond
Q3a
OH


604
CMe
NMe
Q1a
a bond
Me
a bond
CH2
O
NH
Q3a
OH


605
CMe
NMe
Q1a
a bond
H
a bond
CH2
S
a bond
Q3a
OH


606
CMe
NMe
Q1a
a bond
H
a bond
CH2
S
NH
Q3a
OH


607
CMe
NMe
Q1a
a bond
H
a bond
CH2
O
a bond
Q3a
OH


6O8
CMe
NMe
Q1a
a bond
H
a bond
CH2
O
NH
Q3a
OH


609
CMe
NMe
Q1b
a bond
Me
a bond
CH2
S
a bond
Q3a
OH


610
CMe
NMe
Q1b
a bond
Me
a bond
CH2
S
NH
Q3a
OH


611
CMe
NMe
Q1b
a bond
Me
a bond
CH2
O
a bond
Q3a
OH


612
CMe
NMe
Q1b
a bond
Me
a bond
CH2
O
NH
Q3a
OH


613
CMe
NMe
Q1b
a bond
H
a bond
CH2
S
a bond
Q3a
OH


614
CMe
NMe
Q1b
a bond
H
a bond
CH2
S
NH
Q3a
OH


615
CMe
NMe
Q1b
a bond
H
a bond
CH2
O
a bond
Q3a
OH


616
CMe
NMe
Q1b
a bond
H
a bond
CH2
O
NH
Q3a
OH


617
CMe
S
Q1a
a bond
Me
a bond
CH2
S
a bond
Q3a
OH


618
CMe
S
Q1a
a bond
Me
a bond
CH2
S
NH
Q3a
OH


619
CMe
S
Q1a
a bond
Me
a bond
CH2
O
a bond
Q3a
OH


620
CMe
S
Q1a
a bond
Me
a bond
CH2
O
NH
Q3a
OH


621
CMe
S
Q1a
a bond
H
a bond
CH2
S
a bond
Q3a
OH


622
CMe
S
Q1a
a bond
H
a bond
CH2
S
NH
Q3a
OH


623
CMe
S
Q1a
a bond
H
a bond
CH2
O
a bond
Q3a
OH


624
CMe
S
Q1a
a bond
H
a bond
CH2
O
NH
Q3a
OH


625
CMe
S
Q1b
a bond
Me
a bond
CH2
S
a bond
Q3a
OH


626
CMe
S
Q1b
a bond
Me
a bond
CH2
S
NH
Q3a
OH


627
CMe
S
Q1b
a bond
Me
a bond
CH2
O
a bond
Q3a
OH


628
CMe
S
Q1b
a bond
Me
a bond
CH2
O
NH
Q3a
OH


629
CMe
S
Q1b
a bond
H
a bond
CH2
S
a bond
Q3a
OH


630
CMe
S
Q1b
a bond
H
a bond
CH2
S
NH
Q3a
OH


631
CMe
S
Q1b
a bond
H
a bond
CH2
O
a bond
Q3a
OH


632
CMe
S
Q1b
a bond
H
a bond
CH2
O
NH
Q3a
OH


633
CMe
O
Q1a
a bond
Me
a bond
CH2
S
a bond
Q3a
OH


634
CMe
O
Q1a
a bond
Me
a bond
CH2
S
NH
Q3a
OH


635
CMe
O
Q1a
a bond
Me
a bond
CH2
O
a bond
Q3a
OH


636
CMe
O
Q1a
a bond
Me
a bond
CH2
O
NH
Q3a
OH


637
CMe
O
Q1a
a bond
H
a bond
CH2
S
a bond
Q3a
OH


638
CMe
O
Q1a
a bond
H
a bond
CH2
S
NH
Q3a
OH


639
CMe
O
Q1a
a bond
H
a bond
CH2
O
a bond
Q3a
OH


640
CMe
O
Q1a
a bond
H
a bond
CH2
O
NH
Q3a
OH


641
CMe
O
Q1b
a bond
Me
a bond
CH2
S
a bond
Q3a
OH


642
CMe
O
Q1b
a bond
Me
a bond
CH2
S
NH
Q3a
OH


643
CMe
O
Q1b
a bond
Me
a bond
CH2
O
a bond
Q3a
OH


644
CMe
O
Q1b
a bond
Me
a bond
CH2
O
NH
Q3a
OH


645
CMe
O
Q1b
a bond
H
a bond
CH2
S
a bond
Q3a
OH


646
CMe
O
Q1b
a bond
H
a bond
CH2
S
NH
Q3a
OH


647
CMe
O
Q1b
a bond
H
a bond
CH2
O
a bond
Q3a
OH


648
CMe
O
Q1b
a bond
H
a bond
CH2
O
NH
Q3a
OH


649
CMe
NH
Q1a
NH
Me
a bond
NH
S
NH
Q3a
OH


650
CMe
NH
Q1a
NH
Me
a bond
NH
S
a bond
Q3a
OH


651
CMe
NH
Q1a
NH
Me
a bond
NH
O
NH
Q3a
OH


652
CMe
NH
Q1a
NH
Me
a bond
NH
O
a bond
Q3a
OH


653
CMe
NH
Q1a
NH
H
a bond
NH
S
NH
Q3a
OH


654
CMe
NH
Q1a
NH
H
a bond
NH
S
a bond
Q3a
OH


655
CMe
NH
Q1a
NH
H
a bond
NH
O
NH
Q3a
OH


656
CMe
NH
Q1a
NH
H
a bond
NH
O
a bond
Q3a
OH


657
CMe
NH
Q1b
NH
Me
a bond
NH
S
NH
Q3a
OH


658
CMe
NH
Q1b
NH
Me
a bond
NH
S
a bond
Q3a
OH


659
CMe
NH
Q1b
NH
Me
a bond
NH
O
NH
Q3a
OH


660
CMe
NH
Q1b
NH
Me
a bond
NH
O
a bond
Q3a
OH


661
CMe
NH
Q1b
NH
H
a bond
NH
S
NH
Q3a
OH


662
CMe
NH
Q1b
NH
H
a bond
NH
S
a bond
Q3a
OH


663
CMe
NH
Q1b
NH
H
a bond
NH
O
NH
Q3a
OH


664
CMe
NH
Q1b
NH
H
a bond
NH
O
a bond
Q3a
OH


665
CMe
NH
Q1a
O
Me
a bond
NH
S
NH
Q3a
OH


666
CMe
NH
Q1a
O
Me
a bond
NH
S
a bond
Q3a
OH


667
CMe
NH
Q1a
O
Me
a bond
NH
O
NH
Q3a
OH


668
CMe
NH
Q1a
O
Me
a bond
NH
O
a bond
Q3a
OH


669
CMe
NH
Q1a
O
H
a bond
NH
S
NH
Q3a
OH


670
CMe
NH
Q1a
O
H
a bond
NH
S
a bond
Q3a
OH


671
CMe
NH
Q1a
O
H
a bond
NH
O
NH
Q3a
OH


672
CMe
NH
Q1a
O
H
a bond
NH
O
a bond
Q3a
OH


673
CMe
NH
Q1b
O
Me
a bond
NH
S
NH
Q3a
OH


674
CMe
NH
Q1b
O
Me
a bond
NH
S
a bond
Q3a
OH


675
CMe
NH
Q1b
O
Me
a bond
NH
O
NH
Q3a
OH


676
CMe
NH
Q1b
O
Me
a bond
NH
O
a bond
Q3a
OH


677
CMe
NH
Q1b
O
H
a bond
NH
S
NH
Q3a
OH


678
CMe
NH
Q1b
O
H
a bond
NH
S
a bond
Q3a
OH


679
CMe
NH
Q1b
O
H
a bond
NH
O
NH
Q3a
OH


680
CMe
NH
Q1b
O
H
a bond
NH
O
a bond
Q3a
OH


681
CMe
NH
Q1a
CH2
Me
a bond
NH
S
NH
Q3a
OH


682
CMe
NH
Q1a
CH2
Me
a bond
NH
S
a bond
Q3a
OH


683
CMe
NH
Q1a
CH2
Me
a bond
NH
O
NH
Q3a
OH


684
CMe
NH
Q1a
CH2
Me
a bond
NH
O
a bond
Q3a
OH


685
CMe
NH
Q1a
CH2
H
a bond
NH
S
NH
Q3a
OH


686
CMe
NH
Q1a
CH2
H
a bond
NH
S
a bond
Q3a
OH


687
CMe
NH
Q1a
CH2
H
a bond
NH
O
NH
Q3a
OH


688
CMe
NH
Q1a
CH2
H
a bond
NH
O
a bond
Q3a
OH


689
CMe
NH
Q1b
CH2
Me
a bond
NH
S
NH
Q3a
OH


690
CMe
NH
Q1b
CH2
Me
a bond
NH
S
a bond
Q3a
OH


691
CMe
NH
Q1b
CH2
Me
a bond
NH
O
NH
Q3a
OH


692
CMe
NH
Q1b
CH2
Me
a bond
NH
O
a bond
Q3a
OH


693
CMe
NH
Q1b
CH2
H
a bond
NH
S
NH
Q3a
OH


694
CMe
NH
Q1b
CH2
H
a bond
NH
S
a bond
Q3a
OH


695
CMe
NH
Q1b
CH2
H
a bond
NH
O
NH
Q3a
OH


696
CMe
NH
Q1b
CH2
H
a bond
NH
O
a bond
Q3a
OH


697
CMe
NH
Q1a
a bond
Me
a bond
NH
S
CH2
Q3a
OH


698
CMe
NH
Q1a
a bond
Me
a bond
NH
O
CH2
Q3a
OH


699
CMe
NH
Q1a
a bond
H
a bond
NH
S
CH2
Q3a
OH


700
CMe
NH
Q1a
a bond
H
a bond
NH
O
CH2
Q3a
OH


701
CMe
NH
Q1b
a bond
Me
a bond
NH
S
CH2
Q3a
OH


702
CMe
NH
Q1b
a bond
Me
a bond
NH
O
CH2
Q3a
OH


703
CMe
NH
Q1b
a bond
H
a bond
NH
S
CH2
Q3a
OH


704
CMe
NH
Q1b
a bond
H
a bond
NH
O
CH2
Q3a
OH


705
CMe
NH
Q1a
a bond
Me
a bond
CH2
S
a bond
Q3a
OH


706
CMe
NH
Q1a
a bond
Me
a bond
CH2
S
NH
Q3a
OH


707
CMe
NH
Q1a
a bond
Me
a bond
CR2
O
a bond
Q3a
OH


708
CMe
NH
Q1a
a bond
Me
a bond
CH2
O
NH
Q3a
OH


709
CMe
NH
Q1a
a bond
H
a bond
CH2
S
a bond
Q3a
OH


710
CMe
NH
Q1a
a bond
H
a bond
CH2
S
NH
Q3a
OH


711
CMe
NH
Q1a
a bond
H
a bond
CH2
O
a bond
Q3a
OH


712
CMe
NH
Q1a
a bond
H
a bond
CH2
O
NH
Q3a
OH


713
CMe
NH
Q1b
a bond
Me
a bond
CH2
S
a bond
Q3a
OH


714
CMe
NH
Q1b
a bond
Me
a bond
CH2
S
NH
Q3a
OH


715
CMe
NH
Q1b
a bond
Me
a bond
CH2
O
a bond
Q3a
OH


716
CMe
NH
Q1b
a bond
Me
a bond
CH2
O
NH
Q3a
OH


717
CMe
NH
Q1b
a bond
H
a bond
CH2
S
a bond
Q3a
OH


718
CMe
NH
Q1b
a bond
H
a bond
CH2
S
NH
Q3a
OH


719
CMe
NH
Q1b
a bond
H
a bond
CH2
O
a bond
Q3a
OH


720
CMe
NH
Q1b
a bond
H
a bond
CH2
O
NH
Q3a
OH
































71) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 4, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. The symbols in Table 4 denote the flowing substituents.


















TABLE 4





No
A
B
R1
L1
R2
L2
L3
Y
L4
R3
X


























1
N
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3i
OH


2
N
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3j
OH


3
N
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3i
OH


4
N
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3j
OH


5
N
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3i
OH


6
N
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3j
OH


7
N
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3i
OH


8
N
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3j
OH


9
N
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3i
OH


10
N
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3j
OH


11
N
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3i
OH


12
N
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3j
OH


13
N
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3i
OH


14
N
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3j
OH


15
N
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3i
OH


16
N
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3j
OH


17
N
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3i
OH


18
N
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3j
OH


19
N
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3i
OH


20
N
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3j
OH


21
N
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3i
OH


22
N
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3j
OH


23
N
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3i
OH


24
N
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3j
OH


25
CH
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3i
OH


26
CH
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3j
OH


27
CH
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3i
OH


28
CH
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3j
OH


29
CH
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3i
OH


30
CH
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3j
OH


31
CH
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3i
OH


32
CH
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3j
OH


33
CH
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3i
OH


34
CH
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3j
OH


35
CH
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3i
OH


36
CH
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3j
OH


37
CH
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3i
OH


38
CH
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3j
OH


39
CH
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3i
OH


40
CH
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3j
OH


41
CH
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3i
OH


42
CH
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3j
OH


43
CH
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3i
OH


44
CH
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3j
OH


45
CH
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3i
OH


46
CH
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3j
OH


47
CH
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3i
OH


48
CH
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3j
OH


49
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3i
OH


50
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
NH
Q3j
OH


51
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3i
OH


52
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
NH
Q3j
OH


53
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3i
OH


54
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
NH
Q3j
OH


55
CMe
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3i
OH


56
CMe
NEt
Q1a
a bond
Me
a bond
NH
S
NH
Q3j
OH


57
CMe
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3i
OH


58
CMe
NEt
Q1b
a bond
Me
a bond
NH
S
NH
Q3j
OH


59
CMe
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3i
OH


60
CMe
NEt
Q1c
a bond
Me
a bond
NH
S
NH
Q3j
OH


61
CMe
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3i
OH


62
CMe
S
Q1a
a bond
Me
a bond
NH
S
NH
Q3j
OH


63
CMe
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3i
OH


64
CMe
S
Q1b
a bond
Me
a bond
NH
S
NH
Q3j
OH


65
CMe
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3i
OH


66
CMe
S
Q1c
a bond
Me
a bond
NH
S
NH
Q3j
OH


67
CMe
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3i
OH


68
CMe
O
Q1a
a bond
Me
a bond
NH
S
NH
Q3j
OH


69
CMe
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3i
OH


70
CMe
O
Q1b
a bond
Me
a bond
NH
S
NH
Q3j
OH


71
CMe
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3i
OH


72
CMe
O
Q1c
a bond
Me
a bond
NH
S
NH
Q3j
OH


73
N
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3i
OH


74
N
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3j
OH


75
N
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3i
OH


76
N
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3j
OH


77
N
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
Q3i
OH


78
N
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
Q3j
OH


79
N
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3i
OH


80
N
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3j
OH


81
N
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3i
OH


82
N
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3j
OH


83
N
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3i
OH


84
N
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3j
OH


85
N
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3i
OH


86
N
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3j
OH


87
N
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3i
OH


88
N
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3j
OH


89
N
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3i
OH


90
N
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3j
OH


91
N
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3i
OH


92
N
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3j
OH


93
N
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3i
OH


94
N
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3j
OH


95
N
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3i
OH


96
N
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3j
OH


97
CH
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3i
OH


98
CH
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3j
OH


99
CH
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3i
OH


100
CH
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3j
OH


101
CH
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
Q3i
OH


102
CH
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
Q3j
OH


103
CH
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3i
OH


104
CH
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3j
OH


105
CH
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3i
OH


106
CH
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3j
OH


107
CH
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3i
OH


108
CH
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3j
OH


109
CH
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3i
OH


110
CH
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3j
OH


111
CH
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3i
OH


112
CH
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3j
OH


113
CH
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3i
OH


114
CH
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3j
OH


115
CH
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3i
OH


116
CH
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3j
OH


117
CH
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3i
OH


118
CH
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3j
OH


119
CH
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3i
OH


120
CH
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3j
OH


121
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3i
OH


122
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
Q3j
OH


123
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3i
OH


124
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
Q3j
OH


125
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
Q3i
OH


126
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
Q3j
OH


127
CMe
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3i
OH


128
CMe
NEt
Q1a
a bond
Me
a bond
NH
O
a bond
Q3j
OH


129
CMe
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3i
OH


130
CMe
NEt
Q1b
a bond
Me
a bond
NH
O
a bond
Q3j
OH


131
CMe
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3i
OH


132
CMe
NEt
Q1c
a bond
Me
a bond
NH
O
a bond
Q3j
OH


133
CMe
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3i
OH


134
CMe
S
Q1a
a bond
Me
a bond
NH
O
a bond
Q3j
OH


135
CMe
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3i
OH


136
CMe
S
Q1b
a bond
Me
a bond
NH
O
a bond
Q3j
OH


137
CMe
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3i
OH


138
CMe
S
Q1c
a bond
Me
a bond
NH
O
a bond
Q3j
OH


139
CMe
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3i
OH


140
CMe
O
Q1a
a bond
Me
a bond
NH
O
a bond
Q3j
OH


141
CMe
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3i
OH


142
CMe
O
Q1b
a bond
Me
a bond
NH
O
a bond
Q3j
OH


143
CMe
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3i
OH


144
CMe
O
Q1c
a bond
Me
a bond
NH
O
a bond
Q3j
OH


145
CMe
NH
Q1a
a bond
Me
a bond
NH
S
NH
Q3i
OH


146
CMe
NH
Q1a
a bond
Me
a bond
NH
S
NH
Q3j
OH


147
CMe
NH
Q1b
a bond
Me
a bond
NH
S
NH
Q3i
OH


148
CMe
NH
Q1b
a bond
Me
a bond
NH
S
NH
Q3j
OH


149
CMe
NH
Q1c
a bond
Me
a bond
NH
S
NH
Q3i
OH


150
CMe
NH
Q1c
a bond
Me
a bond
NH
S
NH
Q3j
OH


151
CH
NH
Q1a
a bond
Me
a bond
NH
O
a bond
Q3i
OH


152
CH
NH
Q1a
a bond
Me
a bond
NH
O
a bond
Q3j
OH


153
CH
NH
Q1b
a bond
Me
a bond
NH
O
a bond
Q3i
OH


154
CH
NH
Q1b
a bond
Me
a bond
NH
O
a bond
Q3j
OH


155
CH
NH
Q1c
a bond
Me
a bond
NH
O
a bond
Q3i
OH


156
CH
NH
Q1c
a bond
Me
a bond
NH
O
a bond
Q3i
OH












































72) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 5, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. The symbols in Table 5 denote the flowing substituents.


















TABLE 5





No
A
B
R1
L1
R2
L2
L3
Y
L4
R3
X


























1
CMe
NH
Q1k
a bond
Me
a bond
NH
O
a bond
Q3a
OH


2
CMe
NH
Q1k
a bond
Me
a bond
NH
O
a bond
Q3d
OH


3
CMe
NH
Q1k
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4
CMe
NH
Q1k
a bond
Me
a bond
NH
O
a bond
Q3f
OH


5
CMe
NH
Q1k
a bond
Me
a bond
NH
O
NH
Q3a
OH


6
CMe
NH
Q1k
a bond
Me
a bond
NH
O
NH
Q3d
OH


7
CMe
NH
Q1k
a bond
Me
a bond
NH
O
NH
Q3e
OH


8
CMe
NH
Q1k
a bond
Me
a bond
NH
O
NH
Q3f
OH


9
CMe
NH
Q1k
a bond
Me
a bond
NH
S
a bond
Q3a
OH


10
CMe
NH
Q1k
a bond
Me
a bond
NH
S
a bond
Q3d
OH


11
CMe
NH
Q1k
a bond
Me
a bond
NH
S
a bond
Q3e
OH


12
CMe
NH
Q1k
a bond
Me
a bond
NH
S
a bond
Q3f
OH


13
CMe
NH
Q1k
a bond
Me
a bond
NH
S
NH
Q3a
OH


14
CMe
NH
Q1k
a bond
Me
a bond
NH
S
NH
Q3d
OH


15
CMe
NH
Q1k
a bond
Me
a bond
NH
S
NH
Q3e
OH


16
CMe
NH
Q1k
a bond
Me
a bond
NH
S
NH
Q3f
OH


17
CMe
NH
Q1l
a bond
Me
a bond
NH
0
a bond
Q3a
OH


18
CMe
NH
Q1l
a bond
Me
a bond
NH
O
a bond
Q3d
OH


19
CMe
NH
Q1l
a bond
Me
a bond
NH
O
a bond
Q3e
OH


20
CMe
NH
Q1l
a bond
Me
a bond
NH
O
a bond
Q3f
OH


21
CMe
NH
Q1l
a bond
Me
a bond
NH
O
NH
Q3a
OH


22
CMe
NH
Q1l
a bond
Me
a bond
NH
O
NH
Q3d
OH


23
CMe
NH
Q1l
a bond
Me
a bond
NH
O
NH
Q3e
OH


24
CMe
NH
Q1l
a bond
Me
a bond
NH
O
NH
Q3f
OH


25
CMe
NH
Q1l
a bond
Me
a bond
NH
S
a bond
Q3a
OH


26
CMe
NH
Q1l
a bond
Me
a bond
NH
S
a bond
Q3d
OH


27
CMe
NH
Q1l
a bond
Me
a bond
NH
S
a bond
Q3e
OH


28
CMe
NH
Q1l
a bond
Me
a bond
NH
S
a bond
Q3f
OH


29
CMe
NH
Q1l
a bond
Me
a bond
NH
S
NH
Q3a
OH


30
CMe
NH
Q1l
a bond
Me
a bond
NH
S
NH
Q3d
OH


31
CMe
NH
Q1l
a bond
Me
a bond
NH
S
NH
Q3e
OH


32
CMe
NH
Q1l
a bond
Me
a bond
NH
S
NH
Q3f
OH


33
CMe
NH
Q1m
a bond
Me
a bond
NH
O
a bond
Q3a
OH


34
CMe
NH
Q1m
a bond
Me
a bond
NH
O
a bond
Q3d
OH


35
CMe
NH
Q1m
a bond
Me
a bond
NH
O
a bond
Q3e
OH


36
CMe
NH
Q1m
a bond
Me
a bond
NH
O
a bond
Q3f
OH


37
CMe
NH
Q1m
a bond
Me
a bond
NH
O
NH
Q3a
OH


38
CMe
NH
Q1m
a bond
Me
a bond
NH
O
NH
Q3d
OH


39
CMe
NH
Q1m
a bond
Me
a bond
NH
O
NH
Q3e
OH


40
CMe
NH
Q1m
a bond
Me
a bond
NH
O
NH
Q3f
OH


41
CMe
NH
Q1m
a bond
Me
a bond
NH
S
a bond
Q3a
OH


42
CMe
NH
Q1m
a bond
Me
a bond
NH
S
a bond
Q3d
OH


43
CMe
NH
Q1m
a bond
Me
a bond
NH
S
a bond
Q3e
OH


44
CMe
NH
Q1m
a bond
Me
a bond
NH
S
a bond
Q3f
OH


45
CMe
NH
Q1m
a bond
Me
a bond
NH
S
NH
Q3a
OH


46
CMe
NH
Q1m
a bond
Me
a bond
NH
S
NH
Q3d
OH


47
CMe
NH
Q1m
a bond
Me
a bond
NH
S
NH
Q3e
OH


48
CMe
NH
Q1m
a bond
Me
a bond
NH
S
NH
Q3f
OH


49
CMe
NH
Q1n
a bond
Me
a bond
NH
O
a bond
Q3a
OH


50
CMe
NH
Q1n
a bond
Me
a bond
NH
O
a bond
Q3d
OH


51
CMe
NH
Q1n
a bond
Me
a bond
NH
O
a bond
Q3e
OH


52
CMe
NH
Q1n
a bond
Me
a bond
NH
O
a bond
Q3f
OH


53
CMe
NH
Q1n
a bond
Me
a bond
NH
O
NH
Q3a
OH


54
CMe
NH
Q1n
a bond
Me
a bond
NH
O
NH
Q3d
OH


55
CMe
NH
Q1n
a bond
Me
a bond
NH
O
NH
Q3e
OH


56
CMe
NH
Q1n
a bond
Me
a bond
NH
O
NH
Q3f
OH


57
CMe
NH
Q1n
a bond
Me
a bond
NH
S
a bond
Q3a
OH


58
CMe
NH
Q1n
a bond
Me
a bond
NH
S
a bond
Q3d
OH


59
CMe
NH
Q1n
a bond
Me
a bond
NH
S
a bond
Q3e
OH


60
CMe
NH
Q1n
a bond
Me
a bond
NH
S
a bond
Q3f
OH


61
CMe
NH
Q1n
a bond
Me
a bond
NH
S
NH
Q3a
OH


62
CMe
NH
Q1n
a bond
Me
a bond
NH
S
NH
Q3d
OH


63
CMe
NH
Q1n
a bond
Me
a bond
NH
S
NH
Q3e
OH


64
CMe
NH
Q1n
a bond
Me
a bond
NH
S
NH
Q3f
OH


65
CMe
NH
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


66
CMe
NH
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


67
CMe
NH
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


68
CMe
NH
Q1k′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


69
CMe
NH
Q1k′
a bond
Me
a bond
NH
O
NH
Q3a
OH


70
CMe
NH
Q1k′
a bond
Me
a bond
NH
O
NH
Q3d
OH


71
CMe
NH
Q1k′
a bond
Me
a bond
NH
O
NH
Q3e
OH


72
CMe
NH
Q1k′
a bond
Me
a bond
NH
O
NH
Q3f
OH


73
CMe
NH
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


74
CMe
NH
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


75
CMe
NH
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


76
CMe
NH
Q1k′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


77
CMe
NH
Q1k′
a bond
Me
a bond
NH
S
NH
Q3a
OH


78
CMe
NH
Q1k′
a bond
Me
a bond
NH
S
NH
Q3d
OH


79
CMe
NH
Q1k′
a bond
Me
a bond
NH
S
NH
Q3e
OH


80
CMe
NH
Q1k′
a bond
Me
a bond
NH
S
NH
Q3f
OH


81
CMe
NH
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


82
CMe
NH
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


83
CMe
NH
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


84
CMe
NH
Q1l′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


85
CMe
NH
Q1l′
a bond
Me
a bond
NH
O
NH
Q3a
OH


86
CMe
NH
Q1l′
a bond
Me
a bond
NH
O
NH
Q3d
OH


87
CMe
NH
Q1l′
a bond
Me
a bond
NH
O
NH
Q3e
OH


88
CMe
NH
Q1l′
a bond
Me
a bond
NH
O
NH
Q3f
OH


89
CMe
NH
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


90
CMe
NH
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


91
CMe
NH
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


92
CMe
NH
Q1l′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


93
CMe
NH
Q1l′
a bond
Me
a bond
NH
S
NH
Q3a
OH


94
CMe
NH
Q1l′
a bond
Me
a bond
NH
S
NH
Q3d
OH


95
CMe
NH
Q1l′
a bond
Me
a bond
NH
S
NH
Q3e
OH


96
CMe
NH
Q1l′
a bond
Me
a bond
NH
S
NH
Q3f
OH


97
CMe
NH
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


98
CMe
NH
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


99
CMe
NH
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


100
CMe
NH
Q1m′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


101
CMe
NH
Q1m′
a bond
Me
a bond
NH
O
NH
Q3a
OH


102
CMe
NH
Q1m′
a bond
Me
a bond
NH
O
NH
Q3d
OH


103
CMe
NH
Q1m′
a bond
Me
a bond
NH
O
NH
Q3e
OH


104
CMe
NH
Q1m′
a bond
Me
a bond
NH
O
NH
Q3f
OH


105
CMe
NH
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


106
CMe
NH
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


107
CMe
NH
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


108
CMe
NH
Q1m′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


109
CMe
NH
Q1m′
a bond
Me
a bond
NH
S
NH
Q3a
OH


110
CMe
NH
Q1m′
a bond
Me
a bond
NH
S
NH
Q3d
OH


111
CMe
NH
Q1m′
a bond
Me
a bond
NH
S
NH
Q3e
OH


112
CMe
NH
Q1m′
a bond
Me
a bond
NH
S
NH
Q3f
OH


113
CMe
NH
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


114
CMe
NH
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3d
OH


115
CMe
NH
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


116
CMe
NH
Q1n′
a bond
Me
a bond
NH
O
a bond
Q3f
OH


117
CMe
NH
Q1n′
a bond
Me
a bond
NH
O
NH
Q3a
OH


118
CMe
NH
Q1n′
a bond
Me
a bond
NH
O
NH
Q3d
OH


119
CMe
NH
Q1n′
a bond
Me
a bond
NH
O
NH
Q3e
OH


120
CMe
NH
Q1n′
a bond
Me
a bond
NH
O
NH
Q3f
OH


121
CMe
NH
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


122
CMe
NH
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3d
OH


123
CMe
NH
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


124
CMe
NH
Q1n′
a bond
Me
a bond
NH
S
a bond
Q3f
OH


125
CMe
NH
Q1n′
a bond
Me
a bond
NH
S
NH
Q3a
OH


126
CMe
NH
Q1n′
a bond
Me
a bond
NH
S
NH
Q3d
OH


127
CMe
NH
Q1n′
a bond
Me
a bond
NH
S
NH
Q3e
OH


128
CMe
NH
Q1n′
a bond
Me
a bond
NH
S
NH
Q3f
OH


129
CMe
NH
Q1a
a bond
Me
a bond
NH
O
a bond
Q3d
OH


130
CMe
NH
Q1a
a bond
Me
a bond
NH
O
a bond
Q3e
OH


131
CMe
NH
Q1a
a bond
Me
a bond
NH
O
a bond
Q3f
OH


132
CMe
NH
Q1a
a bond
Me
a bond
NH
O
NH
Q3d
OH


133
CMe
NH
Q1a
a bond
Me
a bond
NH
O
NH
Q3e
OH


134
CMe
NH
Q1a
a bond
Me
a bond
NH
O
NH
Q3f
OH


135
CMe
NH
Q1a
a bond
Me
a bond
NH
S
a bond
Q3d
OH


136
CMe
NH
Q1a
a bond
Me
a bond
NH
S
a bond
Q3e
OH


137
CMe
NH
Q1a
a bond
Me
a bond
NH
S
a bond
Q3f
OH


138
CMe
NH
Q1a
a bond
Me
a bond
NH
S
NH
Q3d
OH


139
CMe
NH
Q1a
a bond
Me
a bond
NH
S
NH
Q3e
OH


140
CMe
NH
Q1a
a bond
Me
a bond
NH
S
NH
Q3f
OH


141
CMe
NH
Q1b
a bond
Me
a bond
NH
O
a bond
Q3d
OH


142
CMe
NH
Q1b
a bond
Me
a bond
NH
O
a bond
Q3e
OH


143
CMe
NH
Q1b
a bond
Me
a bond
NH
O
a bond
Q3f
OH


144
CMe
NH
Q1b
a bond
Me
a bond
NH
O
NH
Q3d
OH


145
CMe
NH
Q1b
a bond
Me
a bond
NH
O
NH
Q3e
OH


146
CMe
NH
Q1b
a bond
Me
a bond
NH
O
NH
Q3f
OH


147
CMe
NH
Q1b
a bond
Me
a bond
NH
S
a bond
Q3d
OH


148
CMe
NH
Q1b
a bond
Me
a bond
NH
S
a bond
Q3e
OH


149
CMe
NH
Q1b
a bond
Me
a bond
NH
S
a bond
Q3f
OH


150
CMe
NH
Q1b
a bond
Me
a bond
NH
S
NH
Q3d
OH


151
CMe
NH
Q1b
a bond
Me
a bond
NH
S
NH
Q3e
OH


152
CMe
NH
Q1b
a bond
Me
a bond
NH
S
NH
Q3f
OH


153
CMe
NH
Q1c
a bond
Me
a bond
NH
O
a bond
Q3d
OH


154
CMe
NH
Q1c
a bond
Me
a bond
NH
O
a bond
Q3e
OH


155
CMe
NH
Q1c
a bond
Me
a bond
NH
O
a bond
Q3f
OH


156
CMe
NH
Q1c
a bond
Me
a bond
NH
O
NH
Q3d
OH


157
CMe
NH
Q1c
a bond
Me
a bond
NH
O
NH
Q3e
OH


158
CMe
NH
Q1c
a bond
Me
a bond
NH
O
NH
Q3f
OH


159
CMe
NH
Q1c
a bond
Me
a bond
NH
S
a bond
Q3d
OH


160
CMe
NH
Q1c
a bond
Me
a bond
NH
S
a bond
Q3e
OH


161
CMe
NH
Q1c
a bond
Me
a bond
NH
S
a bond
Q3f
OH


162
CMe
NH
Q1c
a bond
Me
a bond
NH
S
NH
Q3d
OH


163
CMe
NH
Q1c
a bond
Me
a bond
NH
S
NH
Q3e
OH


164
CMe
NH
Q1a
a bond
Me
a bond
NH
S
NH
Q3g
OH


165
CMe
NH
Q1a
a bond
Me
a bond
NH
S
NH
Q3h
OH


166
CMe
NH
Q1b
a bond
Me
a bond
NH
S
NH
Q3g
OH


167
CMe
NH
Q1b
a bond
Me
a bond
NH
S
NH
Q3h
OH


168
CMe
NH
Q1c
a bond
Me
a bond
NH
S
NH
Q3g
OH


169
CMe
NH
Q1c
a bond
Me
a bond
NH
S
NH
Q3h
OH


170
CMe
NH
Q1a
a bond
Me
a bond
NH
O
a bond
Q3g
OH


171
CMe
NH
Q1a
a bond
Me
a bond
NH
O
a bond
Q3h
OH


172
CMe
NH
Q1b
a bond
Me
a bond
NH
O
a bond
Q3g
OH


173
CMe
NH
Q1b
a bond
Me
a bond
NH
O
a bond
Q3h
OH


174
CMe
NH
Q1c
a bond
Me
a bond
NH
S
a bond
Q3g
OH


175
CMe
NH
Q1c
a bond
Me
a bond
NH
S
a bond
Q3h
OH


176
CMe
NH
Q1c
a bond
Me
a bond
NH
S
NH
Q3f
OH




















































































































73) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 6, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. The symbols in Table 6 denote the following substituents.


















TABLE 6





No
A
B
R1
L1
R2
L2
L3
Y
L4
R3
X


























1
N
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3a
OH


2
N
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3b
OH


3
N
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3c
OH


4
N
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3d
OH


5
N
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3e
OH


6
N
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3f
OH


7
N
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3g
OH


8
N
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3h
OH


9
N
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3i
OH


10
N
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3j
OH


11
N
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3a
OH


12
N
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3b
OH


13
N
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3c
OH


14
N
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3d
OH


15
N
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3e
OH


16
N
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3f
OH


17
N
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3g
OH


18
N
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3h
OH


19
N
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3i
OH


20
N
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3j
OH


21
N
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3a
OH


22
N
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3b
OH


23
N
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3c
OH


24
N
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3d
OH


25
N
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3e
OH


26
N
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3f
OH


27
N
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3g
OH


28
N
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3h
OH


29
N
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3i
OH


30
N
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3j
OH


31
N
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3a
OH


32
N
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3b
OH


33
N
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3c
OH


34
N
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3d
OH


35
N
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3e
OH


36
N
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3f
OH


37
N
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3g
OH


38
N
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3h
OH


39
N
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3i
OH


40
N
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3j
OH


41
N
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3a
OH


42
N
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3b
OH


43
N
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3c
OH


44
N
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3d
OH


45
N
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3e
OH


46
N
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3f
OH


47
N
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3g
OH


48
N
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3h
OH


49
N
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3i
OH


50
N
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3j
OH


51
N
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3a
OH


52
N
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3b
OH


53
N
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3c
OH


54
N
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3d
OH


55
N
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3e
OH


56
N
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3f
OH


57
N
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3g
OH


58
N
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3h
OH


59
N
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3i
OH


60
N
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3j
OH


61
N
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3a
OH


62
N
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3b
OH


63
N
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3c
OH


64
N
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3d
OH


65
N
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3e
OH


66
N
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3f
OH


67
N
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3g
OH


68
N
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3h
OH


69
N
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3i
OH


70
N
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3j
OH


71
N
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3a
OH


72
N
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3b
OH


73
N
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3c
OH


74
N
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3d
OH


75
N
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3e
OH


76
N
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3f
OH


77
N
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3g
OH


78
N
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3h
OH


79
N
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3i
OH


80
N
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3j
OH


81
N
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3a
OH


82
N
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3b
OH


83
N
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3c
OH


84
N
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3d
OH


85
N
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3e
OH


86
N
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3f
OH


87
N
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3g
OH


88
N
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3h
OH


89
N
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3i
OH


90
N
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3j
OH


91
N
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3a
OH


92
N
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3b
OH


93
N
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3c
OH


94
N
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3d
OH


95
N
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3e
OH


96
N
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3f
OH


97
N
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3g
OH


98
N
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3h
OH


99
N
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3i
OH


100
N
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3j
OH


101
N
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3a
OH


102
N
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3b
OH


103
N
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3c
OH


104
N
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3d
OH


105
N
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3e
OH


106
N
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3f
OH


107
N
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3g
OH


108
N
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3h
OH


109
N
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3i
OH


110
N
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3j
OH


111
N
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3a
OH


112
N
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3b
OH


113
N
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3c
OH


114
N
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3d
OH


115
N
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3e
OH


116
N
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3f
OH


117
N
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3g
OH


118
N
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3h
OH


119
N
NNe
Q1b
a bond
Me
a bond
NH
O
a bond
T3i
OH


120
N
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3j
OH


121
N
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3a
OH


122
N
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3b
OH


123
N
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3c
OH


124
N
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3d
OH


125
N
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3e
OH


126
N
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3f
OH


127
N
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3g
OH


128
N
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3h
OH


129
N
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3i
OH


130
N
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3j
OH


131
N
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3a
OH


132
N
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3b
OH


133
N
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3c
OH


134
N
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3d
OH


135
N
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3e
OH


136
N
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3f
OH


137
N
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3g
OH


138
N
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3h
OH


139
N
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3i
OH


140
N
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3j
OH


141
N
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3a
OH


142
N
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3b
OH


143
N
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3c
OH


144
N
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3d
OH


145
N
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3e
OH


146
N
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3f
OH


147
N
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3g
OH


148
N
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3h
OH


149
N
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3i
OH


150
N
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3j
OH


151
N
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3a
OH


152
N
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3b
OH


153
N
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3c
OH


154
N
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3d
OH


155
N
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3e
OH


156
N
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3f
OH


157
N
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3g
OH


158
N
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3h
OH


159
N
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3i
OH


160
N
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3j
OH


161
N
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3a
OH


162
N
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3b
OH


163
N
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3c
OH


164
N
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3d
OH


165
N
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3e
OH


166
N
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3f
OH


167
N
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3g
OH


168
N
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3h
OH


169
N
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3i
OH


170
N
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3j
OH


171
N
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3a
OH


172
N
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3b
OH


173
N
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3c
OH


174
N
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3d
OH


175
N
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3e
OH


176
N
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3f
OH


177
N
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3g
OH


178
N
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3h
OH


179
N
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3i
OH


180
N
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3j
OH


181
N
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3a
OH


182
N
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3b
OH


183
N
NNe
Q1c
a bond
Me
a bond
NH
O
NH
T3c
OH


184
N
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3d
OH


185
N
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3e
OH


186
N
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3f
OH


187
N
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3g
OH


188
N
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3h
OH


189
N
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3i
OH


190
N
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3j
OH


191
N
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3a
OH


192
N
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3b
OH


193
N
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3c
OH


194
N
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3d
OH


195
N
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3e
OH


196
N
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3f
OH


197
N
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3g
OH


198
N
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3h
OH


199
N
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3i
OH


200
N
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3j
OH


201
N
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3a
OH


202
N
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3b
OH


203
N
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3c
OH


204
N
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3d
OH


205
N
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3e
OH


206
N
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3f
OH


207
N
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3g
OH


208
N
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3h
OH


209
N
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3i
OH


210
N
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3j
OH


211
N
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3a
OH


212
N
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3b
OH


213
N
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3c
OH


214
N
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3d
OH


215
N
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3e
OH


216
N
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3f
OH


217
N
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3g
OH


218
N
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3h
OH


219
N
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3i
OH


220
N
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3j
OH


221
N
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3a
OH


222
N
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3b
OH


223
N
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3c
OH


224
N
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3d
OH


225
N
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3e
OH


226
N
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3f
OH


227
N
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3g
OH


228
N
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3h
OH


229
N
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3i
OH


230
N
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3j
OH


231
N
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3a
OH


232
N
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3b
OH


233
N
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3c
OH


234
N
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3d
OH


235
N
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3e
OH


236
N
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3f
OH


237
N
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3g
OH


238
N
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3h
OH


239
N
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3i
OH


240
N
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3j
OH


241
N
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3a
OH


242
N
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3b
OH


243
N
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3c
OH


244
N
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3d
OH


245
N
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3e
OH


246
N
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3f
OH


247
N
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3g
OH


248
N
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3h
OH


249
N
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3i
OH


250
N
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3j
OH


251
N
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3a
OH


252
N
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3b
OH


253
N
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3c
OH


254
N
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3d
OH


255
N
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3e
OH


256
N
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3f
OH


257
N
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3g
OH


258
N
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3h
OH


259
N
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3i
OH


260
N
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3j
OH


261
N
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3a
OH


262
N
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3b
OH


263
N
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3c
OH


264
N
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3d
OH


265
N
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3e
OH


266
N
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3f
OH


267
N
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3g
OH


268
N
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3h
OH


269
N
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3i
OH


270
N
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3j
OH


271
N
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3a
OH


272
N
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3b
OH


273
N
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3c
OH


274
N
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3d
OH


275
N
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3e
OH


276
N
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3f
OH


277
N
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3g
OH


278
N
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3h
OH


279
N
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3i
OH


280
N
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3j
OH


281
N
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3a
OH


282
N
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3b
OH


283
N
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3c
OH


284
N
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3d
OH


285
N
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3e
OH


286
N
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3f
OH


287
N
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3g
OH


288
N
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3h
OH


289
N
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3i
OH


290
N
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3j
OH


291
N
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3a
OH


292
N
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3b
OH


293
N
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3c
OH


294
N
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3d
OH


295
N
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3e
OH


296
N
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3f
OH


297
N
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3g
OH


298
N
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3h
OH


299
N
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3i
OH


300
N
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3j
OH


301
N
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3a
OH


302
N
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3b
OH


303
N
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3c
OH


304
N
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3d
OH


305
N
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3e
OH


306
N
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3f
OH


307
N
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3g
OH


308
N
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3h
OH


309
N
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3i
OH


310
N
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3j
OH


311
N
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3a
OH


312
N
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3b
OH


313
N
NNe
Q1i
a bond
H
a bond
NH
O
a bond
T3c
OH


314
N
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3d
OH


315
N
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3e
OH


316
N
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3f
OH


317
N
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3g
OH


318
N
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3h
OH


319
N
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3i
OH


320
N
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3j
OH


321
N
NMe
Q1j
a bond
Me
a bond
NH
S
NH
T3a
OH


322
N
NMe
Q1j
a bond
Me
a bond
NH
S
NH
T3b
OH


323
N
NMe
Q1j
a bond
Me
a bond
NH
S
NH
T3c
OH


324
N
NMe
Q1j
a bond
Me
a bond
NH
S
NH
T3d
OH


325
N
NMe
Q1j
a bond
Me
a bond
NH
S
NH
T3e
OH


326
N
NMe
Q1j
a bond
Me
a bond
NH
S
NH
T3f
OH


327
N
NMe
Q1j
a bond
Me
a bond
NH
S
NH
T3g
OH


328
N
NMe
Q1j
a bond
Me
a bond
NH
S
NH
T3h
OH


329
N
NMe
Q1j
a bond
Me
a bond
NH
S
NH
T3i
OH


330
N
NMe
Q1j
a bond
Me
a bond
NH
S
NH
T3j
OH


331
N
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3a
OH


332
N
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3b
OH


333
N
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3c
OH


334
N
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3d
OH


335
N
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3e
OH


336
N
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3f
OH


337
N
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3g
OH


338
N
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3h
OH


339
N
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3i
OH


340
N
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3j
OH


341
N
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3a
OH


342
N
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3b
OH


343
N
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3c
OH


344
N
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3d
OH


345
N
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3e
OH


346
N
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3f
OH


347
N
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3g
OH


348
N
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3h
OH


349
N
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3i
OH


350
N
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3j
OH


351
N
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3a
OH


352
N
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3b
OH


353
N
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3c
OH


354
N
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3d
OH


355
N
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3e
OH


356
N
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3f
OH


357
N
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3g
OH


358
N
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3h
OH


359
N
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3i
OH


360
N
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3j
OH


361
N
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3a
OH


362
N
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3b
OH


363
N
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3c
OH


364
N
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3d
OH


365
N
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3e
OH


366
N
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3f
OH


367
N
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3g
OH


368
N
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3h
OH


369
N
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3i
OH


370
N
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3j
OH


371
N
NNe
Q1j
a bond
H
a bond
NH
S
a bond
T3a
OH


372
N
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3b
OH


373
N
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3c
OH


374
N
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3d
OH


375
N
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3e
OH


376
N
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3f
OH


377
N
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3g
OH


378
N
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3h
OH


379
N
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3i
OH


380
N
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3j
OH


381
N
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3a
OH


382
N
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3b
OH


383
N
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3c
OH


384
N
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3d
OH


385
N
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3e
OH


386
N
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3f
OH


387
N
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3g
OH


388
N
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3h
OH


389
N
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3i
OH


390
N
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3j
OH


391
N
NMe
Q1j
abond
H
a bond
NH
O
a bond
T3a
OH


392
N
NMe
Q1j
a bond
H
a bond
NH
O
a bond
T3b
OH


393
N
NMe
Q1j
a bond
H
a bond
NH
O
a bond
T3c
OH


394
N
NMe
Q1j
a bond
H
a bond
NH
O
a bond
T3d
OH


395
N
NMe
Q1j
a bond
H
a bond
NH
O
a bond
T3e
OH


396
N
NMe
Q1j
a bond
H
a bond
NH
O
a bond
T3f
OH


397
N
NMe
Q1j
a bond
H
a bond
NH
O
a bond
T3g
OH


398
N
NMe
Q1j
a bond
H
a bond
NH
O
a bond
T3h
OH


399
N
NMe
Q1j
a bond
H
a bond
NH
O
a bond
T3i
OH


400
N
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3j
OH


401
N
S
Q1a
a bond
Me
a bond
NH
S
NH
T3a
OH


402
N
S
Q1a
a bond
Me
a bond
NH
S
NH
T3b
OH


403
N
S
Q1a
a bond
Me
a bond
NH
S
NH
T3c
OH


404
N
S
Q1a
a bond
Me
a bond
NH
S
NH
T3d
OH


405
N
S
Q1a
a bond
Me
a bond
NH
S
NH
T3e
OH


406
N
S
Q1a
a bond
Me
a bond
NH
S
NH
T3f
OH


407
N
S
Q1a
a bond
Me
a bond
NH
S
NH
T3g
OH


408
N
S
Q1a
a bond
Me
a bond
NH
S
NH
T3h
OH


409
N
S
Q1a
a bond
Me
a bond
NH
S
NH
T3i
OH


410
N
S
Q1a
a bond
Me
a bond
NH
S
NH
T3j
OH


411
N
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3a
OH


412
N
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3b
OH


413
N
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3c
OH


414
N
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3d
OH


415
N
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3e
OH


416
N
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3f
OH


417
N
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3g
OH


418
N
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3h
OH


419
N
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3i
OH


420
N
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3j
OH


421
N
S
Q1a
a bond
Me
a bond
NH
O
NH
T3a
OH


422
N
S
Q1a
a bond
Me
a bond
NH
O
NH
T3b
OH


423
N
S
Q1a
a bond
Me
a bond
NH
O
NH
T3c
OH


424
N
S
Q1a
a bond
Me
a bond
NH
O
NH
T3d
OH


425
N
S
Q1a
a bond
Me
a bond
NH
O
NH
T3e
OH


426
N
S
Q1a
a bond
Me
a bond
NH
O
NH
T3f
OH


427
N
S
Q1a
a bond
Me
a bond
NH
O
NH
T3g
OH


428
N
S
Q1a
a bond
Me
a bond
NH
O
NH
T3h
OH


429
N
S
Q1a
a bond
Me
a bond
NH
O
NH
T3i
OH


430
N
S
Q1a
a bond
Me
a bond
NH
O
NH
T3j
OH


431
N
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3a
OH


432
N
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3b
OH


433
N
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3c
OH


434
N
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3d
OH


435
N
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3e
OH


436
N
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3f
OH


437
N
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3g
OH


438
N
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3h
OH


439
N
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3i
OH


440
N
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3j
OH


441
N
S
Q1a
a bond
H
a bond
NH
S
NH
T3a
OH


442
N
S
Q1a
a bond
H
a bond
NH
S
NH
T3b
OH


443
N
S
Q1a
a bond
H
a bond
NH
S
NH
T3c
OH


444
N
S
Q1a
a bond
H
a bond
NH
S
NH
T3d
OH


445
N
S
Q1a
a bond
H
a bond
NH
S
NH
T3e
OH


446
N
S
Q1a
a bond
H
a bond
NH
S
NH
T3f
OH


447
N
S
Q1a
a bond
H
a bond
NH
S
NH
T3g
OH


448
N
S
Q1a
a bond
H
a bond
NH
S
NH
T3h
OH


449
N
S
Q1a
a bond
H
a bond
NH
S
NH
T3i
OH


450
N
S
Q1a
a bond
H
a bond
NH
S
NH
T3j
OH


451
N
S
Q1a
a bond
H
a bond
NH
S
a bond
T3a
OH


452
N
S
Q1a
a bond
H
a bond
NH
S
a bond
T3b
OH


453
N
S
Q1a
a bond
H
a bond
NH
S
a bond
T3c
OH


454
N
S
Q1a
a bond
H
a bond
NH
S
a bond
T3d
OH


455
N
S
Q1a
a bond
H
a bond
NH
S
a bond
T3e
OH


456
N
S
Q1a
a bond
H
a bond
NH
S
a bond
T3f
OH


457
N
S
Q1a
a bond
H
a bond
NH
S
a bond
T3g
OH


458
N
S
Q1a
a bond
H
a bond
NH
S
a bond
T3h
OH


459
N
S
Q1a
a bond
H
a bond
NH
S
a bond
T3i
OH


460
N
S
Q1a
a bond
H
a bond
NH
S
a bond
T3j
OH


461
N
S
Q1a
a bond
H
a bond
NH
O
NH
T3a
OH


462
N
S
Q1a
a bond
H
a bond
NH
O
NH
T3b
OH


463
N
S
Q1a
a bond
H
a bond
NH
O
NH
T3c
OH


464
N
S
Q1a
a bond
H
a bond
NH
O
NH
T3d
OH


465
N
S
Q1a
a bond
H
a bond
NH
O
NH
T3e
OH


466
N
S
Q1a
a bond
H
a bond
NH
O
NH
T3f
OH


467
N
S
Q1a
a bond
H
a bond
NH
O
NH
T3g
OH


468
N
S
Q1a
a bond
H
a bond
NH
O
NH
T3h
OH


469
N
S
Q1a
a bond
H
a bond
NH
O
NH
T3i
OH


470
N
S
Q1a
a bond
H
a bond
NH
O
NH
T3j
OH


471
N
S
Q1a
a bond
H
a bond
NH
O
a bond
T3a
OH


472
N
S
Q1a
a bond
H
a bond
NH
O
a bond
T3b
OH


473
N
S
Q1a
a bond
H
a bond
NH
O
a bond
T3c
OH


474
N
S
Q1a
a bond
H
a bond
NH
O
a bond
T3d
OH


475
N
S
Q1a
a bond
H
a bond
NH
O
a bond
T3e
OH


476
N
S
Q1a
a bond
H
a bond
NH
O
a bond
T3f
OH


477
N
S
Q1a
a bond
H
a bond
NH
O
a bond
T3g
OH


478
N
S
Q1a
a bond
H
a bond
NH
O
a bond
T3h
OH


479
N
S
Q1a
a bond
H
a bond
NH
O
a bond
T3i
OH


480
N
S
Q1a
a bond
H
a bond
NH
O
a bond
T3j
OH


481
N
S
Q1b
a bond
Me
a bond
NH
S
NH
T3a
OH


482
N
S
Q1b
a bond
Me
a bond
NH
S
NH
T3b
OH


483
N
S
Q1b
a bond
Me
a bond
NH
S
NH
T3c
OH


484
N
S
Q1b
a bond
Me
a bond
NH
S
NH
T3d
OH


485
N
S
Q1b
a bond
Me
a bond
NH
S
NH
T3e
OH


486
N
S
Q1b
a bond
Me
a bond
NH
S
NH
T3f
OH


487
N
S
Q1b
a bond
Me
a bond
NH
S
NH
T3g
OH


488
N
S
Q1b
a bond
Me
a bond
NH
S
NH
T3h
OH


489
N
S
Q1b
a bond
Me
a bond
NH
S
NH
T3i
OH


490
N
S
Q1b
a bond
Me
a bond
NH
S
NH
T3j
OH


491
N
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3a
OH


492
N
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3b
OH


493
N
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3c
OH


494
N
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3d
OH


495
N
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3e
OH


496
N
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3f
OH


497
N
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3g
OH


498
N
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3h
OH


499
N
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3i
OH


500
N
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3j
OH


501
N
S
Q1b
a bond
Me
a bond
NH
O
NH
T3a
OH


502
N
S
Q1b
a bond
Me
a bond
NH
O
NH
T3b
OH


503
N
S
Q1b
a bond
Me
a bond
NH
O
NH
T3c
OH


504
N
S
Q1b
a bond
Me
a bond
NH
O
NH
T3d
OH


505
N
S
Q1b
a bond
Me
a bond
NH
O
NH
T3e
OH


506
N
S
Q1b
a bond
Me
a bond
NH
O
NH
T3f
OH


507
N
S
Q1b
a bond
Me
a bond
NH
O
NH
T3g
OH


508
N
S
Q1b
a bond
Me
a bond
NH
O
NH
T3h
OH


509
N
S
Q1b
a bond
Me
a bond
NH
O
NH
T3i
OH


510
N
S
Q1b
a bond
Me
a bond
NH
O
NH
T3j
OH


511
N
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3a
OH


512
N
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3b
OH


513
N
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3c
OH


514
N
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3d
OH


515
N
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3e
OH


516
N
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3f
OH


517
N
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3g
OH


518
N
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3h
OH


519
N
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3i
OH


520
N
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3j
OH


521
N
S
Q1b
a bond
H
a bond
NH
S
NH
T3a
OH


522
N
S
Q1b
a bond
H
a bond
NH
S
NH
T3b
OH


523
N
S
Q1b
a bond
H
a bond
NH
S
NH
T3c
OH


524
N
S
Q1b
a bond
H
a bond
NH
S
NH
T3d
OH


525
N
S
Q1b
a bond
H
a bond
NH
S
NH
T3e
OH


526
N
S
Q1b
a bond
H
a bond
NH
S
NH
T3f
OH


527
N
S
Q1b
a bond
H
a bond
NH
S
NH
T3g
OH


528
N
S
Q1b
a bond
H
a bond
NH
S
NH
T3h
OH


529
N
S
Q1b
a bond
H
a bond
NH
S
NH
T3i
OH


530
N
S
Q1b
a bond
H
a bond
NH
S
NH
T3j
OH


531
N
S
Q1b
a bond
H
a bond
NH
S
a bond
T3a
OH


532
N
S
Q1b
a bond
H
a bond
NH
S
a bond
T3b
OH


533
N
S
Q1b
a bond
H
a bond
NH
S
a bond
T3c
OH


534
N
S
Q1b
a bond
H
a bond
NH
S
a bond
T3d
OH


535
N
S
Q1b
a bond
H
a bond
NH
S
a bond
T3e
OH


536
N
S
Q1b
a bond
H
a bond
NH
S
a bond
T3f
OH


537
N
S
Q1b
a bond
H
a bond
NH
S
a bond
T3g
OH


538
N
S
Q1b
a bond
H
a bond
NH
S
a bond
T3h
OH


539
N
S
Q1b
a bond
H
a bond
NH
S
a bond
T3i
OH


540
N
S
Q1b
a bond
H
a bond
NH
S
a bond
T3j
OH


541
N
S
Q1b
a bond
H
a bond
NH
O
NH
T3a
OH


542
N
S
Q1b
a bond
H
a bond
NH
O
NH
T3b
OH


543
N
S
Q1b
a bond
H
a bond
NH
O
NH
T3c
OH


544
N
S
Q1b
a bond
H
a bond
NH
O
NH
T3d
OH


545
N
S
Q1b
a bond
H
a bond
NH
O
NH
T3e
OH


546
N
S
Q1b
a bond
H
a bond
NH
O
NH
T3f
OH


547
N
S
Q1b
a bond
H
a bond
NH
O
NH
T3g
OH


548
N
S
Q1b
a bond
H
a bond
NH
O
NH
T3h
OH


549
N
S
Q1b
a bond
H
a bond
NH
O
NH
T3i
OH


550
N
S
Q1b
a bond
H
a bond
NH
O
NH
T3j
OH


551
N
S
Q1b
a bond
H
a bond
NH
O
a bond
T3a
OH


552
N
S
Q1b
a bond
H
a bond
NH
O
a bond
T3b
OH


553
N
S
Q1b
a bond
H
a bond
NH
O
a bond
T3c
OH


554
N
S
Q1b
a bond
H
a bond
NH
O
a bond
T3d
OH


555
N
S
Q1b
a bond
H
a bond
NH
O
a bond
T3e
OH


556
N
S
Q1b
a bond
H
a bond
NH
O
a bond
T3f
OH


557
N
S
Q1b
a bond
H
a bond
NH
O
a bond
T3g
OH


558
N
S
Q1b
a bond
H
a bond
NH
O
a bond
T3h
OH


559
N
S
Q1b
a bond
H
a bond
NH
O
a bond
T3i
OH


560
N
S
Q1b
a bond
H
a bond
NH
O
a bond
T3j
OH


561
N
S
Q1c
a bond
Me
a bond
NH
S
NH
T3a
OH


562
N
S
Q1c
a bond
Me
a bond
NH
S
NH
T3b
OH


563
N
S
Q1c
a bond
Me
a bond
NH
S
NH
T3c
OH


564
N
S
Q1c
a bond
Me
a bond
NH
S
NH
T3d
OH


565
N
S
Q1c
a bond
Me
a bond
NH
S
NH
T3e
OH


566
N
S
Q1c
a bond
Me
a bond
NH
S
NH
T3f
OH


567
N
S
Q1c
a bond
Me
a bond
NH
S
NH
T3g
OH


568
N
S
Q1c
a bond
Me
a bond
NH
S
NH
T3h
OH


569
N
S
Q1c
a bond
Me
a bond
NH
S
NH
T3i
OH


570
N
S
Q1c
a bond
Me
a bond
NH
S
NH
T3j
OH


571
N
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3a
OH


572
N
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3b
OH


573
N
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3c
OH


574
N
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3d
OH


575
N
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3e
OH


576
N
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3f
OH


577
N
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3g
OH


578
N
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3h
OH


579
N
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3i
OH


580
N
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3j
OH


581
N
S
Q1c
a bond
Me
a bond
NH
O
NH
T3a
OH


582
N
S
Q1c
a bond
Me
a bond
NH
O
NH
T3b
OH


583
N
S
Q1c
a bond
Me
a bond
NH
O
NH
T3c
OH


584
N
S
Q1c
a bond
Me
a bond
NH
O
NH
T3d
OH


585
N
S
Q1c
a bond
Me
a bond
NH
O
NH
T3e
OH


586
N
S
Q1c
a bond
Me
a bond
NH
O
NH
T3f
OH


587
N
S
Q1c
a bond
Me
a bond
NH
O
NH
T3g
OH


588
N
S
Q1c
a bond
Me
a bond
NH
O
NH
T3h
OH


589
N
S
Q1c
a bond
Me
a bond
NH
O
NH
T3i
OH


590
N
S
Q1c
a bond
Me
a bond
NH
O
NH
T3j
OH


591
N
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3a
OH


592
N
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3b
OH


593
N
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3c
OH


594
N
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3d
OH


595
N
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3e
OH


596
N
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3f
OH


597
N
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3g
OH


598
N
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3h
OH


599
N
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3i
OH


600
N
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3j
OH


601
N
S
Q1c
a bond
H
a bond
NH
S
NH
T3a
OH


602
N
S
Q1c
a bond
H
a bond
NH
S
NH
T3b
OH


603
N
S
Q1c
a bond
H
a bond
NH
S
NH
T3c
OH


604
N
S
Q1c
a bond
H
a bond
NH
S
NH
T3d
OH


605
N
S
Q1c
a bond
H
a bond
NH
S
NH
T3e
OH


606
N
S
Q1c
a bond
H
a bond
NH
S
NH
T3f
OH


607
N
S
Q1c
a bond
H
a bond
NH
S
NH
T3g
OH


608
N
S
Q1c
a bond
H
a bond
NH
S
NH
T3h
OH


609
N
S
Q1c
a bond
H
a bond
NH
S
NH
T3i
OH


610
N
S
Q1c
a bond
H
a bond
NH
S
NH
T3j
OH


611
N
S
Q1c
a bond
H
a bond
NH
S
a bond
T3a
OH


612
N
S
Q1c
a bond
H
a bond
NH
S
a bond
T3b
OH


613
N
S
Q1c
a bond
H
a bond
NH
S
a bond
T3c
OH


614
N
S
Q1c
a bond
H
a bond
NH
S
a bond
T3d
OH


615
N
S
Q1c
a bond
H
a bond
NH
S
a bond
T3e
OH


616
N
S
Q1c
a bond
H
a bond
NH
S
a bond
T3f
OH


617
N
S
Q1c
a bond
H
a bond
NH
S
a bond
T3g
OH


618
N
S
Q1c
a bond
H
a bond
NH
S
a bond
T3h
OH


619
N
S
Q1c
a bond
H
a bond
NH
S
a bond
T3i
OH


620
N
S
Q1c
a bond
H
a bond
NH
S
a bond
T3j
OH


621
N
S
Q1c
a bond
H
a bond
NH
O
NH
T3a
OH


622
N
S
Q1c
a bond
H
a bond
NH
O
NH
T3b
OH


623
N
S
Q1c
a bond
H
a bond
NH
O
NH
T3c
OH


624
N
S
Q1c
a bond
H
a bond
NH
O
NH
T3d
OH


625
N
S
Q1c
a bond
H
a bond
NH
O
NH
T3e
OH


626
N
S
Q1c
a bond
H
a bond
NH
O
NH
T3f
OH


627
N
S
Q1c
a bond
H
a bond
NH
O
NH
T3g
OH


628
N
S
Q1c
a bond
H
a bond
NH
O
NH
T3h
OH


629
N
S
Q1c
a bond
H
a bond
NH
O
NH
T3i
OH


630
N
S
Q1c
a bond
H
a bond
NH
O
NH
T3j
OH


631
N
S
Q1c
a bond
H
a bond
NH
O
a bond
T3a
OH


632
N
S
Q1c
a bond
H
a bond
NH
O
a bond
T3b
OH


633
N
S
Q1c
a bond
H
a bond
NH
O
a bond
T3c
OH


634
N
S
Q1c
a bond
H
a bond
NH
O
a bond
T3d
OH


635
N
S
Q1c
a bond
H
a bond
NH
O
a bond
T3e
OH


636
N
S
Q1c
a bond
H
a bond
NH
O
a bond
T3f
OH


637
N
S
Q1c
a bond
H
a bond
NH
O
a bond
T3g
OH


638
N
S
Q1c
a bond
H
a bond
NH
O
a bond
T3h
OH


639
N
S
Q1c
a bond
H
a bond
NH
O
a bond
T3i
OH


640
N
S
Q1c
a bond
H
a bond
NH
O
a bond
T3j
OH


641
N
S
Q1i
a bond
Me
a bond
NH
S
NH
T3a
OH


642
N
S
Q1i
a bond
Me
a bond
NH
S
NH
T3b
OH


643
N
S
Q1i
a bond
Me
a bond
NH
S
NH
T3c
OH


644
N
S
Q1i
a bond
Me
a bond
NH
S
NH
T3d
OH


645
N
S
Q1i
a bond
Me
a bond
NH
S
NH
T3e
OH


646
N
S
Q1i
a bond
Me
a bond
NH
S
NH
T3f
OH


647
N
S
Q1i
a bond
Me
a bond
NH
S
NH
T3g
OH


648
N
S
Q1i
a bond
Me
a bond
NH
S
NH
T3h
OH


649
N
S
Q1i
abond
Me
a bond
NH
S
NH
T3i
OH


650
N
S
Q1i
a bond
Me
a bond
NH
S
NH
T3j
OH


651
N
S
Q1i
abond
Me
a bond
NH
S
a bond
T3a
OH


652
N
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3b
OH


653
N
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3c
OH


654
N
S
Q1i
abond
Me
a bond
NH
S
a bond
T3d
OH


655
N
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3e
OH


656
N
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3f
OH


657
N
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3g
OH


658
N
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3h
OH


659
N
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3i
OH


660
N
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3j
OH


661
N
S
Q1i
a bond
Me
a bond
NH
O
NH
T3a
OH


662
N
S
Q1i
a bond
Me
a bond
NH
O
NH
T3b
OH


663
N
S
Q1i
a bond
Me
a bond
NH
O
NH
T3c
OH


664
N
S
Q1i
a bond
Me
a bond
NH
O
NH
T3d
OH


665
N
S
Q1i
a bond
Me
a bond
NH
O
NH
T3e
OH


666
N
S
Q1i
a bond
Me
a bond
NH
O
NH
T3f
OH


667
N
S
Q1i
a bond
Me
a bond
NH
O
NH
T3g
OH


668
N
S
Q1i
a bond
Me
a bond
NH
O
NH
T3h
OH


669
N
S
Q1i
a bond
Me
a bond
NH
O
NH
T3i
OH


670
N
S
Q1i
a bond
Me
a bond
NH
O
NH
T3j
OH


671
N
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3a
OH


672
N
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3b
OH


673
N
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3c
OH


674
N
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3d
OH


675
N
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3e
OH


676
N
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3f
OH


677
N
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3g
OH


678
N
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3h
OH


679
N
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3i
OH


680
N
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3j
OH


681
N
S
Q1i
a bond
H
a bond
NH
S
NH
T3a
OH


682
N
S
Q1i
a bond
H
a bond
NH
S
NH
T3b
OH


683
N
S
Q1i
a bond
H
a bond
NH
S
NH
T3c
OH


684
N
S
Q1i
a bond
H
a bond
NH
S
NH
T3d
OH


685
N
S
Q1i
a bond
H
a bond
NH
S
NH
T3e
OH


686
N
S
Q1i
a bond
H
a bond
NH
S
NH
T3f
OH


687
N
S
Q1i
a bond
H
a bond
NH
S
NH
T3g
OH


688
N
S
Q1i
a bond
H
a bond
NH
S
NH
T3h
OH


689
N
S
Q1i
a bond
H
a bond
NH
S
NH
T3i
OH


690
N
S
Q1i
a bond
H
a bond
NH
S
NH
T3j
OH


691
N
S
Q1i
a bond
H
a bond
NH
S
a bond
T3a
OH


692
N
S
Q1i
a bond
H
a bond
NH
S
a bond
T3b
OH


693
N
S
Q1i
a bond
H
a bond
NH
S
a bond
T3c
OH


694
N
S
Q1i
a bond
H
a bond
NH
S
a bond
T3d
OH


695
N
S
Q1i
a bond
H
a bond
NH
S
a bond
T3e
OH


696
N
S
Q1i
a bond
H
a bond
NH
S
a bond
T3f
OH


697
N
S
Q1i
a bond
H
a bond
NH
S
a bond
T3g
OH


698
N
S
Q1i
a bond
H
a bond
NH
S
a bond
T3h
OH


699
N
S
Q1i
a bond
H
a bond
NH
S
a bond
T3i
OH


700
N
S
Q1i
a bond
H
a bond
NH
S
a bond
T3j
OH


701
N
S
Q1i
a bond
H
a bond
NH
O
NH
T3a
OH


702
N
S
Q1i
a bond
H
a bond
NH
O
NH
T3b
OH


703
N
S
Q1i
a bond
H
a bond
NH
O
NH
T3c
OH


704
N
S
Q1i
a bond
H
a bond
NH
O
NH
T3d
OH


705
N
S
Q1i
a bond
H
a bond
NH
O
NH
T3e
OH


706
N
S
Q1i
a bond
H
a bond
NH
O
NH
T3f
OH


707
N
S
Q1i
a bond
H
a bond
NH
O
NH
T3g
OH


708
N
S
Q1i
a bond
H
a bond
NH
O
NH
T3h
OH


709
N
S
Q1i
a bond
H
a bond
NH
O
NH
T3i
OH


710
N
S
Q1i
a bond
H
a bond
NH
O
NH
T3j
OH


711
N
S
Q1i
a bond
H
a bond
NH
O
a bond
T3a
OH


712
N
S
Q1i
a bond
H
a bond
NH
O
a bond
T3b
OH


713
N
S
Q1i
a bond
H
a bond
NH
O
a bond
T3c
OH


714
N
S
Q1i
a bond
H
a bond
NH
O
a bond
T3d
OH


715
N
S
Q1i
a bond
H
a bond
NH
O
a bond
T3e
OH


716
N
S
Q1i
a bond
H
a bond
NH
O
a bond
T3f
OH


717
N
S
Q1i
a bond
H
a bond
NH
O
a bond
T3g
OH


718
N
S
Q1i
a bond
H
a bond
NH
O
a bond
T3h
OH


719
N
S
Q1i
a bond
H
a bond
NH
O
a bond
T3i
OH


720
N
S
Q1i
a bond
H
a bond
NH
O
a bond
T3j
OH


721
N
S
Q1j
a bond
Me
a bond
NH
S
NH
T3a
OH


722
N
S
Q1j
a bond
Me
a bond
NH
S
NH
T3b
OH


723
N
S
Q1j
a bond
Me
a bond
NH
S
NH
T3c
OH


724
N
S
Q1j
a bond
Me
a bond
NH
S
NH
T3d
OH


725
N
S
Q1j
a bond
Me
a bond
NH
S
NH
T3e
OH


726
N
S
Q1j
a bond
Me
a bond
NH
S
NH
T3f
OH


727
N
S
Q1j
a bond
Me
a bond
NH
S
NH
T3g
OH


728
N
S
Q1j
a bond
Me
a bond
NH
S
NH
T3h
OH


729
N
S
Q1j
a bond
Me
a bond
NH
S
NH
T3i
OH


730
N
S
Q1j
a bond
Me
a bond
NH
S
NH
T3j
OH


731
N
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3a
OH


732
N
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3b
OH


733
N
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3c
OH


734
N
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3d
OH


735
N
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3e
OH


736
N
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3f
OH


737
N
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3g
OH


738
N
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3h
OH


739
N
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3i
OH


740
N
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3j
OH


741
N
S
Q1j
a bond
Me
a bond
NH
O
NH
T3a
OH


742
N
S
Q1j
a bond
Me
a bond
NH
O
NH
T3b
OH


743
N
S
Q1j
a bond
Me
a bond
NH
O
NH
T3c
OH


744
N
S
Q1j
a bond
Me
a bond
NH
O
NH
T3d
OH


745
N
S
Q1j
a bond
Me
a bond
NH
O
NH
T3e
OH


746
N
S
Q1j
a bond
Me
a bond
NH
O
NH
T3f
OH


747
N
S
Q1j
a bond
Me
a bond
NH
O
NH
T3g
OH


748
N
S
Q1j
a bond
Me
a bond
NH
O
NH
T3h
OH


749
N
S
Q1j
a bond
Me
a bond
NH
O
NH
T3i
OH


750
N
S
Q1j
a bond
Me
a bond
NH
O
NH
T3j
OH


751
N
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3a
OH


752
N
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3b
OH


753
N
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3c
OH


754
N
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3d
OH


755
N
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3e
OH


756
N
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3f
OH


757
N
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3g
OH


758
N
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3h
OH


759
N
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3i
OH


760
N
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3j
OH


761
N
S
Q1j
a bond
H
a bond
NH
S
NH
T3a
OH


762
N
S
Q1j
a bond
H
a bond
NH
S
NH
T3b
OH


763
N
S
Q1j
a bond
H
a bond
NH
S
NH
T3c
OH


764
N
S
Q1i
a bond
H
a bond
NH
S
NH
T3d
OH


765
N
S
Q1j
a bond
H
a bond
NH
S
NH
T3e
OH


766
N
S
Q1j
a bond
H
a bond
NH
S
NH
T3f
OH


767
N
S
Q1j
a bond
H
a bond
NH
S
NH
T3g
OH


768
N
S
Q1j
a bond
H
a bond
NH
S
NH
T3h
OH


769
N
S
Q1j
a bond
H
a bond
NH
S
NH
T3i
OH


770
N
S
Q1j
a bond
H
a bond
NH
S
NH
T3j
OH


771
N
S
Q1j
a bond
H
a bond
NH
S
a bond
T3a
OH


772
N
S
Q1j
a bond
H
a bond
NH
S
a bond
T3b
OH


773
N
S
Q1i
a bond
H
a bond
NH
S
a bond
T3c
OH


774
N
S
Q1i
a bond
H
a bond
NH
S
a bond
T3d
OH


775
N
S
Q1j
a bond
H
a bond
NH
S
a bond
T3e
OH


776
N
S
Q1j
a bond
H
a bond
NH
S
a bond
T3f
OH


777
N
S
Q1j
a bond
H
a bond
NH
S
a bond
T3g
OH


778
N
S
Q1j
a bond
H
a bond
NH
S
a bond
T3h
OH


779
N
S
Q1j
a bond
H
a bond
NH
S
a bond
T3i
OH


780
N
S
Q1j
a bond
H
a bond
NH
S
a bond
T3j
OH


781
N
S
Q1j
a bond
H
a bond
NH
O
NH
T3a
OH


782
N
S
Q1i
a bond
H
a bond
NH
O
NH
T3b
OH


783
N
S
Q1j
a bond
H
a bond
NH
O
NH
T3c
OH


784
N
S
Q1j
a bond
H
a bond
NH
O
NH
T3d
OH


785
N
S
Q1j
a bond
H
a bond
NH
O
NH
T3e
OH


786
N
S
Q1j
a bond
H
a bond
NH
O
NH
T3f
OH


787
N
S
Q1j
a bond
H
a bond
NH
O
NH
T3g
OH


788
N
S
Q1j
a bond
H
a bond
NH
O
NH
T3h
OH


789
N
S
Q1j
a bond
H
a bond
NH
O
NH
T3i
OH


790
N
S
Q1j
a bond
H
a bond
NH
O
NH
T3j
OH


791
N
S
Q1j
a bond
H
a bond
NH
O
a bond
T3a
OH


792
N
S
Q1j
a bond
H
a bond
NH
O
a bond
T3b
OH


793
N
S
Q1j
a bond
H
a bond
NH
O
a bond
T3c
OH


794
N
S
Q1j
a bond
H
a bond
NH
O
a bond
T3d
OH


795
N
S
Q1j
a bond
H
a bond
NH
O
a bond
T3e
OH


796
N
S
Q1j
a bond
H
a bond
NH
O
a bond
T3f
OH


797
N
S
Q1j
a bond
H
a bond
NH
O
a bond
T3g
OH


798
N
S
Q1j
a bond
H
a bond
NH
O
a bond
T3h
OH


799
N
S
Q1j
a bond
H
a bond
NH
O
a bond
T3i
OH


800
N
S
Q1j
a bond
H
a bond
NH
O
a bond
T3j
OH


801
N
O
Q1a
a bond
Me
a bond
NH
S
NH
T3a
OH


802
N
O
Q1a
a bond
Me
a bond
NH
S
NH
T3b
OH


803
N
O
Q1a
a bond
Me
a bond
NH
S
NH
T3c
OH


804
N
O
Q1a
a bond
Me
a bond
NH
S
NH
T3d
OH


805
N
O
Q1a
a bond
Me
a bond
NH
S
NH
T3e
OH


806
N
O
Q1a
a bond
Me
a bond
NH
S
NH
T3f
OH


807
N
O
Q1a
a bond
Me
a bond
NH
S
NH
T3g
OH


808
N
O
Q1a
a bond
Me
a bond
NH
S
NH
T3h
OH


809
N
O
Q1a
a bond
Me
a bond
NH
S
NH
T3i
OH


810
N
O
Q1a
a bond
Me
a bond
NH
S
NH
T3j
OH


811
N
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3a
OH


812
N
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3b
OH


813
N
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3c
OH


814
N
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3d
OH


815
N
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3e
OH


816
N
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3f
OH


817
N
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3g
OH


818
N
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3h
OH


819
N
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3i
OH


820
N
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3j
OH


821
N
O
Q1a
a bond
Me
a bond
NH
O
NH
T3a
OH


822
N
O
Q1a
a bond
Me
a bond
NH
O
NH
T3b
OH


823
N
O
Q1a
a bond
Me
a bond
NH
O
NH
T3c
OH


824
N
O
Q1a
a bond
Me
a bond
NH
O
NH
T3d
OH


825
N
O
Q1a
a bond
Me
a bond
NH
O
NH
T3e
OH


826
N
O
Q1a
a bond
Me
a bond
NH
O
NH
T3f
OH


827
N
O
Q1a
a bond
Me
a bond
NH
O
NH
T3g
OH


828
N
O
Q1a
a bond
Me
a bond
NH
O
NH
T3h
OH


829
N
O
Q1a
a bond
Me
a bond
NH
O
NH
T3i
OH


830
N
O
Q1a
a bond
Me
a bond
NH
O
NH
T3j
OH


831
N
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3a
OH


832
N
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3b
OH


833
N
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3c
OH


834
N
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3d
OH


835
N
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3e
OH


836
N
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3f
OH


837
N
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3g
OH


838
N
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3h
OH


839
N
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3i
OH


840
N
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3j
OH


841
N
O
Q1a
a bond
H
a bond
NH
S
NH
T3a
OH


842
N
O
Q1a
a bond
H
a bond
NH
S
NH
T3b
OH


843
N
O
Q1a
a bond
H
a bond
NH
S
NH
T3c
OH


844
N
O
Q1a
a bond
H
a bond
NH
S
NH
T3d
OH


845
N
O
Q1a
a bond
H
a bond
NH
S
NH
T3e
OH


846
N
O
Q1a
a bond
H
a bond
NH
S
NH
T3f
OH


847
N
O
Q1a
a bond
H
a bond
NH
S
NH
T3g
OH


848
N
O
Q1a
a bond
H
a bond
NH
S
NH
T3h
OH


849
N
O
Q1a
a bond
H
a bond
NH
S
NH
T3i
OH


850
N
O
Q1a
a bond
H
a bond
NH
S
NH
T3i
OH


851
N
O
Q1a
a bond
H
a bond
NH
S
a bond
T3a
OH


852
N
O
Q1a
a bond
H
a bond
NH
S
a bond
T3b
OH


853
N
O
Q1a
a bond
H
a bond
NH
S
a bond
T3c
OH


854
N
O
Q1a
a bond
H
a bond
NH
S
a bond
T3d
OH


855
N
O
Q1a
a bond
H
a bond
NH
S
a bond
T3e
OH


856
N
O
Q1a
a bond
H
a bond
NH
S
a bond
T3f
OH


857
N
O
Q1a
a bond
H
a bond
NH
S
a bond
T3g
OH


858
N
O
Q1a
a bond
H
a bond
NH
S
a bond
T3h
OH


859
N
O
Q1a
a bond
H
a bond
NH
S
a bond
T3i
OH


860
N
O
Q1a
a bond
H
a bond
NH
S
a bond
T3j
OH


861
N
O
Q1a
a bond
H
a bond
NH
O
NH
T3a
OH


862
N
O
Q1a
a bond
H
a bond
NH
O
NH
T3b
OH


863
N
O
Q1a
a bond
H
a bond
NH
O
NH
T3c
OH


864
N
O
Q1a
a bond
H
a bond
NH
O
NH
T3d
OH


865
N
O
Q1a
a bond
H
a bond
NH
O
NH
T3e
OH


866
N
O
Q1a
a bond
H
a bond
NH
O
NH
T3f
OH


867
N
O
Q1a
a bond
H
a bond
NH
O
NH
T3g
OH


868
N
O
Q1a
a bond
H
a bond
NH
O
NH
T3h
OH


869
N
O
Q1a
a bond
H
a bond
NH
O
NH
T3i
OH


870
N
O
Q1a
a bond
H
a bond
NH
O
NH
T3j
OH


871
N
O
Q1a
a bond
H
a bond
NH
O
a bond
T3a
OH


872
N
O
Q1a
a bond
H
a bond
NH
O
a bond
T3b
OH


873
N
O
Q1a
a bond
H
a bond
NH
O
a bond
T3c
OH


874
N
O
Q1a
a bond
H
a bond
NH
O
a bond
T3d
OH


875
N
O
Q1a
a bond
H
a bond
NH
O
a bond
T3e
OH


876
N
O
Q1a
a bond
H
a bond
NH
O
a bond
T3f
OH


877
N
O
Q1a
a bond
H
a bond
NH
O
a bond
T3g
OH


878
N
O
Q1a
a bond
H
a bond
NH
O
a bond
T3h
OH


879
N
O
Q1a
a bond
H
a bond
NH
O
a bond
T3i
OH


880
N
O
Q1a
a bond
H
a bond
NH
O
a bond
T3i
OH


881
N
O
Q1b
a bond
Me
a bond
NH
S
NH
T3a
OH


882
N
O
Q1b
a bond
Me
a bond
NH
S
NH
T3b
OH


883
N
O
Q1b
a bond
Me
a bond
NH
S
NH
T3c
OH


884
N
O
Q1b
a bond
Me
a bond
NH
S
NH
T3d
OH


885
N
O
Q1b
a bond
Me
a bond
NH
S
NH
T3e
OH


886
N
O
Q1b
a bond
Me
a bond
NH
S
NH
T3f
OH


887
N
O
Q1b
a bond
Me
a bond
NH
S
NH
T3g
OH


888
N
O
Q1b
a bond
Me
a bond
NH
S
NH
T3h
OH


889
N
O
Q1b
a bond
Me
a bond
NH
S
NH
T3i
OH


890
N
O
Q1b
a bond
Me
a bond
NH
S
NH
T3j
OH


891
N
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3a
OH


892
N
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3b
OH


893
N
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3c
OH


894
N
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3d
OH


895
N
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3e
OH


896
N
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3f
OH


897
N
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3g
OH


898
N
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3h
OH


899
N
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3i
OH


900
N
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3j
OH


901
N
O
Q1b
a bond
Me
a bond
NH
O
NH
T3a
OH


902
N
O
Q1b
a bond
Me
a bond
NH
O
NH
T3b
OH


903
N
O
Q1b
a bond
Me
a bond
NH
O
NH
T3c
OH


904
N
O
Q1b
a bond
Me
a bond
NH
O
NH
T3d
OH


905
N
O
Q1b
a bond
Me
a bond
NH
O
NH
T3e
OH


906
N
O
Q1b
a bond
Me
a bond
NH
O
NH
T3f
OH


907
N
O
Q1b
a bond
Me
a bond
NH
O
NH
T3g
OH


908
N
O
Q1b
a bond
Me
a bond
NH
O
NH
T3h
OH


909
N
O
Q1b
a bond
Me
a bond
NH
O
NH
T3i
OH


910
N
O
Q1b
a bond
Me
a bond
NH
O
NH
T3j
OH


911
N
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3a
OH


912
N
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3b
OH


913
N
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3c
OH


914
N
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3d
OH


915
N
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3e
OH


916
N
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3f
OH


917
N
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3g
OH


918
N
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3h
OH


919
N
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3i
OH


920
N
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3j
OH


921
N
O
Q1b
a bond
H
a bond
NH
S
NH
T3a
OH


922
N
O
Q1b
a bond
H
a bond
NH
S
NH
T3b
OH


923
N
O
Q1b
a bond
H
a bond
NH
S
NH
T3c
OH


924
N
O
Q1b
a bond
H
a bond
NH
S
NH
T3d
OH


925
N
O
Q1b
a bond
H
a bond
NH
S
NH
T3e
OH


926
N
O
Q1b
a bond
H
a bond
NH
S
NH
T3f
OH


927
N
O
Q1b
a bond
H
a bond
NH
S
NH
T3g
OH


928
N
O
Q1b
a bond
H
a bond
NH
S
NH
T3h
OH


929
N
O
Q1b
a bond
H
a bond
NH
S
NH
T3i
OH


930
N
O
Q1b
a bond
H
a bond
NH
S
NH
T3j
OH


931
N
O
Q1b
a bond
H
a bond
NH
S
a bond
T3a
OH


932
N
O
Q1b
a bond
H
a bond
NH
S
a bond
T3b
OH


933
N
O
Q1b
a bond
H
a bond
NH
S
a bond
T3c
OH


934
N
O
Q1b
a bond
H
a bond
NH
S
a bond
T3d
OH


935
N
O
Q1b
a bond
H
a bond
NH
S
a bond
T3e
OH


936
N
O
Q1b
a bond
H
a bond
NH
S
a bond
T3f
OH


937
N
O
Q1b
a bond
H
a bond
NH
S
a bond
T3g
OH


938
N
O
Q1b
a bond
H
a bond
NH
S
a bond
T3h
OH


939
N
O
Q1b
a bond
H
a bond
NH
S
a bond
T3i
OH


940
N
O
Q1b
a bond
H
a bond
NH
S
a bond
T3j
OH


941
N
O
Q1b
a bond
H
a bond
NH
O
NH
T3a
OH


942
N
O
Q1b
a bond
H
a bond
NH
O
NH
T3b
OH


943
N
O
Q1b
a bond
H
a bond
NH
O
NH
T3c
OH


944
N
O
Q1b
a bond
H
a bond
NH
O
NH
T3d
OH


945
N
O
Q1b
a bond
H
a bond
NH
O
NH
T3e
OH


946
N
O
Q1b
a bond
H
a bond
NH
O
NH
T3f
OH


947
N
O
Q1b
a bond
H
a bond
NH
O
NH
T3g
OH


948
N
O
Q1b
a bond
H
a bond
NH
O
NH
T3h
OH


949
N
O
Q1b
a bond
H
a bond
NH
O
NH
T3i
OH


950
N
O
Q1b
a bond
H
a bond
NH
O
NH
T3j
OH


951
N
O
Q1b
a bond
H
a bond
NH
O
a bond
T3a
OH


952
N
O
Q1b
a bond
H
a bond
NH
O
a bond
T3b
OH


953
N
O
Q1b
a bond
H
a bond
NH
O
a bond
T3c
OH


954
N
O
Q1b
a bond
H
a bond
NH
O
a bond
T3d
OH


955
N
O
Q1b
a bond
H
a bond
NH
O
a bond
T3e
OH


956
N
O
Q1b
a bond
H
a bond
NH
O
a bond
T3f
OH


957
N
O
Q1b
a bond
H
a bond
NH
O
a bond
T3g
OH


958
N
O
Q1b
a bond
H
a bond
NH
O
a bond
T3h
OH


959
N
O
Q1b
a bond
H
a bond
NH
O
a bond
T3i
OH


960
N
O
Q1b
a bond
H
a bond
NH
O
a bond
T3j
OH


961
N
O
Q1c
a bond
Me
a bond
NH
S
NH
T3a
OH


962
N
O
Q1c
a bond
Me
a bond
NH
S
NH
T3b
OH


963
N
O
Q1c
a bond
Me
a bond
NH
S
NH
T3c
OH


964
N
O
Q1c
a bond
Me
a bond
NH
S
NH
T3d
OH


965
N
O
Q1c
a bond
Me
a bond
NH
S
NH
T3e
OH


966
N
O
Q1c
a bond
Me
a bond
NH
S
NH
T3f
OH


967
N
O
Q1c
a bond
Me
a bond
NH
S
NH
T3g
OH


968
N
O
Q1c
a bond
Me
a bond
NH
S
NH
T3h
OH


969
N
O
Q1c
a bond
Me
a bond
NH
S
NH
T3i
OH


970
N
O
Q1c
a bond
Me
a bond
NH
S
NH
T3j
OH


971
N
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3a
OH


972
N
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3b
OH


973
N
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3c
OH


974
N
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3d
OH


975
N
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3e
OH


976
N
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3f
OH


977
N
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3g
OH


978
N
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3h
OH


979
N
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3i
OH


980
N
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3j
OH


981
N
O
Q1c
a bond
Me
a bond
NH
O
NH
T3a
OH


982
N
O
Q1c
a bond
Me
a bond
NH
O
NH
T3b
OH


983
N
O
Q1c
a bond
Me
a bond
NH
O
NH
T3c
OH


984
N
O
Q1c
a bond
Me
a bond
NH
O
NH
T3d
OH


985
N
O
Q1c
a bond
Me
a bond
NH
O
NH
T3e
OH


986
N
O
Q1c
a bond
Me
a bond
NH
O
NH
T3f
OH


987
N
O
Q1c
a bond
Me
a bond
NH
O
NH
T3g
OH


988
N
O
Q1c
a bond
Me
a bond
NH
O
NH
T3h
OH


989
N
O
Q1c
a bond
Me
a bond
NH
O
NH
T3i
OH


990
N
O
Q1c
a bond
Me
a bond
NH
O
NH
T3j
OH


991
N
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3a
OH


992
N
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3b
OH


993
N
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3c
OH


994
N
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3d
OH


995
N
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3e
OH


996
N
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3f
OH


997
N
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3g
OH


998
N
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3h
OH


999
N
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3i
OH


1000
N
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3j
OH


1001
N
O
Q1c
a bond
H
a bond
NH
S
NH
T3a
OH


1002
N
O
Q1c
a bond
H
a bond
NH
S
NH
T3b
OH


1003
N
O
Q1c
a bond
H
a bond
NH
S
NH
T3c
OH


1004
N
O
Q1c
a bond
H
a bond
NH
S
NH
T3d
OH


1005
N
O
Q1c
a bond
H
a bond
NH
S
NH
T3e
OH


1006
N
O
Q1c
a bond
H
a bond
NH
S
NH
T3f
OH


1007
N
O
Q1c
a bond
H
a bond
NH
S
NH
T3g
OH


1008
N
O
Q1c
a bond
H
a bond
NH
S
NH
T3h
OH


1009
N
O
Q1c
a bond
H
a bond
NH
S
NH
T3i
OH


1010
N
O
Q1c
a bond
H
a bond
NH
S
NH
T3j
OH


1011
N
O
Q1c
a bond
H
a bond
NH
S
a bond
T3a
OH


1012
N
O
Q1c
a bond
H
a bond
NH
S
a bond
T3b
OH


1013
N
O
Q1c
a bond
H
a bond
NH
S
a bond
T3c
OH


1014
N
O
Q1c
a bond
H
a bond
NH
S
a bond
T3d
OH


1015
N
O
Q1c
a bond
H
a bond
NH
S
a bond
T3e
OH


1016
N
O
Q1c
a bond
H
a bond
NH
S
a bond
T3f
OH


1017
N
O
Q1c
a bond
H
a bond
NH
S
a bond
T3g
OH


1018
N
O
Q1c
a bond
H
a bond
NH
S
a bond
T3h
OH


1019
N
O
Q1c
a bond
H
a bond
NH
S
a bond
T3i
OH


1020
N
O
Q1c
a bond
H
a bond
NH
S
a bond
T3j
OH


1021
N
O
Q1c
a bond
H
a bond
NH
O
NH
T3a
OH


1022
N
O
Q1c
a bond
H
a bond
NH
O
NH
T3b
OH


1023
N
O
Q1c
a bond
H
a bond
NH
O
NH
T3c
OH


1024
N
O
Q1c
a bond
H
a bond
NH
O
NH
T3d
OH


1025
N
O
Q1c
a bond
H
a bond
NH
O
NH
T3e
OH


1026
N
O
Q1c
a bond
H
a bond
NH
O
NH
T3f
OH


1027
N
O
Q1c
a bond
H
a bond
NH
O
NH
T3g
OH


1028
N
O
Q1c
a bond
H
a bond
NH
O
NH
T3h
OH


1029
N
O
Q1c
a bond
H
a bond
NH
O
NH
T3i
OH


1030
N
O
Q1c
a bond
H
a bond
NH
O
NH
T3j
OH


1031
N
O
Q1c
a bond
H
a bond
NH
O
a bond
T3a
OH


1032
N
O
Q1c
a bond
H
a bond
NH
O
a bond
T3b
OH


1033
N
O
Q1c
a bond
H
a bond
NH
O
a bond
T3c
OH


1034
N
O
Q1c
a bond
H
a bond
NH
O
a bond
T3d
OH


1035
N
O
Q1c
a bond
H
a bond
NH
O
a bond
T3e
OH


1036
N
O
Q1c
a bond
H
a bond
NH
O
a bond
T3f
OH


1037
N
O
Q1c
a bond
H
a bond
NH
O
a bond
T3g
OH


1038
N
O
Q1c
a bond
H
a bond
NH
O
a bond
T3h
OH


1039
N
O
Q1c
a bond
H
a bond
NH
O
a bond
T3i
OH


1040
N
O
Q1c
a bond
H
a bond
NH
O
a bond
T3j
OH


1041
N
O
Q1i
a bond
Me
a bond
NH
S
NH
T3a
OH


1042
N
O
Q1i
a bond
Me
a bond
NH
S
NH
T3b
OH


1043
N
O
Q1i
a bond
Me
a bond
NH
S
NH
T3c
OH


1044
N
O
Q1i
a bond
Me
a bond
NH
S
NH
T3d
OH


1045
N
O
Q1i
a bond
Me
a bond
NH
S
NH
T3e
OH


1046
N
O
Q1i
a bond
Me
a bond
NH
S
NH
T3f
OH


1047
N
O
Q1i
a bond
Me
a bond
NH
S
NH
T3g
OH


1048
N
O
Q1i
a bond
Me
a bond
NH
S
NH
T3h
OH


1049
N
O
Q1i
a bond
Me
a bond
NH
S
NH
T3i
OH


1050
N
O
Q1i
a bond
Me
a bond
NH
S
NH
T3j
OH


1051
N
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3a
OH


1052
N
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3b
OH


1053
N
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3c
OH


1054
N
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3d
OH


1055
N
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3e
OH


1056
N
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3f
OH


1057
N
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3g
OH


1058
N
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3h
OH


1059
N
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3i
OH


1060
N
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3j
OH


1061
N
O
Q1i
a bond
Me
a bond
NH
O
NH
T3a
OH


1062
N
O
Q1i
a bond
Me
a bond
NH
O
NH
T3b
OH


1063
N
O
Q1i
a bond
Me
a bond
NH
O
NH
T3c
OH


1064
N
O
Q1i
a bond
Me
a bond
NH
O
NH
T3d
OH


1065
N
O
Q1i
a bond
Me
a bond
NH
O
NH
T3e
OH


1066
N
O
Q1i
a bond
Me
a bond
NH
O
NH
T3f
OH


1067
N
O
Q1i
a bond
Me
a bond
NH
O
NH
T3g
OH


1068
N
O
Q1i
a bond
Me
a bond
NH
O
NH
T3h
OH


1069
N
O
Q1i
a bond
Me
a bond
NH
O
NH
T3i
OH


1070
N
O
Q1i
a bond
Me
a bond
NH
O
NH
T3j
OH


1071
N
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3a
OH


1072
N
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3b
OH


1073
N
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3c
OH


1074
N
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3d
OH


1075
N
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3e
OH


1076
N
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3f
OH


1077
N
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3g
OH


1078
N
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3h
OH


1079
N
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3i
OH


1080
N
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3j
OH


1081
N
O
Q1i
a bond
H
a bond
NH
S
NH
T3a
OH


1082
N
O
Q1i
a bond
H
a bond
NH
S
NH
T3b
OH


1083
N
O
Q1i
a bond
H
a bond
NH
S
NH
T3c
OH


1084
N
O
Q1i
a bond
H
a bond
NH
S
NH
T3d
OH


1085
N
O
Q1i
a bond
H
a bond
NH
S
NH
T3e
OH


1086
N
O
Q1i
a bond
H
a bond
NH
S
NH
T3f
OH


1087
N
O
Q1i
a bond
H
a bond
NH
S
NH
T3g
OH


1088
N
O
Q1i
a bond
H
a bond
NH
S
NH
T3h
OH


1089
N
O
Q1i
a bond
H
a bond
NH
S
NH
T3i
OH


1090
N
O
Q1i
a bond
H
a bond
NH
S
NH
T3j
OH


1091
N
O
Q1i
a bond
H
a bond
NH
S
a bond
T3a
OH


1092
N
O
Q1i
a bond
H
a bond
NH
S
a bond
T3b
OH


1093
N
O
Q1i
a bond
H
a bond
NH
S
a bond
T3c
OH


1094
N
O
Q1i
a bond
H
a bond
NH
S
a bond
T3d
OH


1095
N
O
Q1i
a bond
H
a bond
NH
S
a bond
T3e
OH


1096
N
O
Q1i
a bond
H
a bond
NH
S
a bond
T3f
OH


1097
N
O
Q1i
a bond
H
a bond
NH
S
a bond
T3g
OH


1098
N
O
Q1i
a bond
H
a bond
NH
S
a bond
T3h
OH


1099
N
O
Q1i
a bond
H
a bond
NH
S
a bond
T3i
OH


1100
N
O
Q1i
a bond
H
a bond
NH
S
a bond
T3j
OH


1101
N
O
Q1i
a bond
H
a bond
NH
O
NH
T3a
OH


1102
N
O
Q1i
a bond
H
a bond
NH
O
NH
T3b
OH


1103
N
O
Q1i
a bond
H
a bond
NH
O
NH
T3c
OH


1104
N
O
Q1i
a bond
H
a bond
NH
O
NH
T3d
OH


1105
N
O
Q1i
a bond
H
a bond
NH
O
NH
T3e
OH


1106
N
O
Q1i
a bond
H
a bond
NH
O
NH
T3f
OH


1107
N
O
Q1i
a bond
H
a bond
NH
O
NH
T3g
OH


1108
N
O
Q1i
a bond
H
a bond
NH
O
NH
T3h
OH


1109
N
O
Q1i
a bond
H
a bond
NH
O
NH
T3i
OH


1110
N
O
Q1i
a bond
H
a bond
NH
O
NH
T3j
OH


1111
N
O
Q1i
a bond
H
a bond
NH
O
a bond
T3a
OH


1112
N
O
Q1i
a bond
H
a bond
NH
O
a bond
T3b
OH


1113
N
O
Q1i
a bond
H
a bond
NH
O
a bond
T3c
OH


1114
N
O
Q1i
a bond
H
a bond
NH
O
a bond
T3d
OH


1115
N
O
Q1i
a bond
H
a bond
NH
O
a bond
T3e
OH


1116
N
O
Q1i
a bond
H
a bond
NH
O
a bond
T3f
OH


1117
N
O
Q1i
a bond
H
a bond
NH
O
a bond
T3g
OH


1118
N
O
Oh
a bond
H
a bond
NH
O
a bond
T3h
OH


1119
N
O
Q1i
a bond
H
a bond
NH
O
a bond
T3i
OH


1120
N
O
Q1i
a bond
H
a bond
NH
O
a bond
T3j
OH


1121
N
O
Q1j
a bond
Me
a bond
NH
S
NH
T3a
OH


1122
N
O
Q1j
a bond
Me
a bond
NH
S
NH
T3b
OH


1123
N
O
Q1j
a bond
Me
a bond
NH
S
NH
T3c
OH


1124
N
O
Q1j
a bond
Me
a bond
NH
S
NH
T3d
OH


1125
N
O
Q1j
a bond
Me
a bond
NH
S
NH
T3e
OH


1126
N
O
Q1j
a bond
Me
a bond
NH
S
NH
T3f
OH


1127
N
O
Q1j
a bond
Me
a bond
NH
S
NH
T3g
OH


1128
N
O
Q1j
a bond
Me
a bond
NH
S
NH
T3h
OH


1129
N
O
Q1j
a bond
Me
a bond
NH
S
NH
T3i
OH


1130
N
O
Q1j
a bond
Me
a bond
NH
S
NH
T3j
OH


1131
N
O
Q1j
a bond
Me
a bond
NH
S
a bond
T3a
OH


1132
N
O
Q1j
a bond
Me
a bond
NH
S
a bond
T3b
OH


1133
N
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3c
OH


1134
N
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3d
OH


1135
N
O
Q1j
a bond
Me
a bond
NH
S
a bond
T3e
OH


1136
N
O
Q1j
a bond
Me
a bond
NH
S
a bond
T3f
OH


1137
N
O
Q1j
a bond
Me
a bond
NH
S
a bond
T3g
OH


1138
N
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3h
OH


1139
N
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3i
OH


1140
N
O
Q1j
a bond
Me
a bond
NH
S
a bond
T3j
OH


1141
N
O
Q1j
a bond
Me
a bond
NH
O
NH
T3a
OH


1142
N
O
Q1j
a bond
Me
a bond
NH
O
NH
T3b
OH


1143
N
O
Q1j
a bond
Me
a bond
NH
O
NH
T3c
OH


1144
N
O
Q1j
a bond
Me
a bond
NH
O
NH
T3d
OH


1145
N
O
Q1j
a bond
Me
a bond
NH
O
NH
T3e
OH


1146
N
O
Q1j
a bond
Me
a bond
NH
O
NH
T3f
OH


1147
N
O
Q1j
a bond
Me
a bond
NH
O
NH
T3g
OH


1148
N
O
Q1j
a bond
Me
a bond
NH
O
NH
T3h
OH


1149
N
O
Q1j
a bond
Me
a bond
NH
O
NH
T3i
OH


1150
N
O
Q1j
a bond
Me
a bond
NH
O
NH
T3j
OH


1151
N
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3a
OH


1152
N
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3b
OH


1153
N
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3c
OH


1154
N
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3d
OH


1155
N
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3e
OH


1156
N
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3f
OH


1157
N
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3g
OH


1158
N
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3h
OH


1159
N
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3i
OH


1160
N
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3j
OH


1161
N
O
Q1j
a bond
H
a bond
NH
S
NH
T3a
OH


1162
N
O
Q1j
a bond
H
a bond
NH
S
NH
T3b
OH


1163
N
O
Q1j
a bond
H
a bond
NH
S
NH
T3c
OH


1164
N
O
Q1j
a bond
H
a bond
NH
S
NH
T3d
OH


1165
N
O
Q1j
a bond
H
a bond
NH
S
NH
T3e
OH


1166
N
O
Q1j
a bond
H
a bond
NH
S
NH
T3f
OH


1167
N
O
Q1j
a bond
H
a bond
NH
S
NH
T3g
OH


1168
N
O
Q1j
a bond
H
a bond
NH
S
NH
T3h
OH


1169
N
O
Q1j
a bond
H
a bond
NH
S
NH
T3i
OH


1170
N
O
Q1j
a bond
H
a bond
NH
S
NH
T35
OH


1171
N
O
Q1i
a bond
H
a bond
NH
S
a bond
T3a
OH


1172
N
O
Q1j
a bond
H
a bond
NH
S
a bond
T3b
OH


1173
N
O
Q1j
a bond
H
a bond
NH
S
a bond
T3c
OH


1174
N
O
Q1j
a bond
H
a bond
NH
S
a bond
T3d
OH


1175
N
O
Q1i
a bond
H
a bond
NH
S
a bond
T3e
OH


1176
N
O
Q1j
a bond
H
a bond
NH
S
a bond
T3f
OH


1177
N
O
Q1j
a bond
H
a bond
NH
S
a bond
T3g
OH


1178
N
O
Q1j
a bond
H
a bond
NH
S
a bond
T3h
OH


1179
N
O
Q1j
a bond
H
a bond
NH
S
a bond
T3i
OH


1180
N
O
Q1j
a bond
H
a bond
NH
S
a bond
T3j
OH


1181
N
O
Q1j
a bond
H
a bond
NH
O
NH
T3a
OH


1182
N
O
Q1j
a bond
H
a bond
NH
O
NH
T3b
OH


1183
N
O
Q1j
a bond
H
a bond
NH
O
NH
T3c
OH


1184
N
O
Q1j
a bond
H
a bond
NH
O
NH
T3d
OH


1185
N
O
Q1j
a bond
H
a bond
NH
O
NH
T3e
OH


1186
N
O
Q1j
a bond
H
a bond
NH
O
NH
T3f
OH


1187
N
O
Q1j
a bond
H
a bond
NH
O
NH
T3g
OH


1188
N
O
Q1j
a bond
H
a bond
NH
O
NH
T3h
OH


1189
N
O
Q1j
a bond
H
a bond
NH
O
NH
T3i
OH


1190
N
O
Q1j
a bond
H
a bond
NH
O
NH
T3j
OH


1191
N
O
Q1j
a bond
H
a bond
NH
O
a bond
T3a
OH


1192
N
O
Q1j
a bond
H
a bond
NH
O
a bond
T3b
OH


1193
N
O
Q1j
a bond
H
a bond
NH
O
a bond
T3c
OH


1194
N
O
Q1j
a bond
H
a bond
NH
O
a bond
T3d
OH


1195
N
O
Q1j
a bond
H
a bond
NH
O
a bond
T3e
OH


1196
N
O
Q1j
a bond
H
a bond
NH
O
a bond
T3f
OH


1197
N
O
Q1j
a bond
H
a bond
NH
O
a bond
T3g
OH


1198
N
O
Q1j
a bond
H
a bond
NH
O
a bond
T3h
OH


1199
N
O
Q1j
a bond
H
a bond
NH
O
a bond
T3i
OH


1200
N
O
Q1j
a bond
H
a bond
NH
O
a bond
T3j
OH


1201
CH
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3a
OH


1202
CH
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3b
OH


1203
CH
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3c
OH


1204
CH
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3d
OH


1205
CH
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3e
OH


1206
CH
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3f
OH


1207
CH
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3g
OH


1208
CH
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3h
OH


1209
CH
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3i
OH


1210
CH
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3j
OH


1211
CH
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3a
OH


1212
CH
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3b
OH


1213
CH
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3c
OH


1214
CH
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3d
OH


1215
CH
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3e
OH


1216
CH
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3f
OH


1217
CH
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3g
OH


1218
CH
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3h
OH


1219
CH
NNe
Q1a
a bond
Me
a bond
NH
S
a bond
T3i
OH


1220
CH
NNe
Q1a
a bond
Me
a bond
NH
S
a bond
T3j
OH


1221
CH
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3a
OH


1222
CH
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3b
OH


1223
CH
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3c
OH


1224
CH
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3d
OH


1225
CH
NNe
Q1a
a bond
Me
a bond
NH
O
NH
T3e
OH


1226
CH
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3f
OH


1227
CH
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3g
OH


1228
CH
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3h
OH


1229
CH
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3i
OH


1230
CH
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3j
OH


1231
CH
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3a
OH


1232
CH
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3b
OH


1233
CH
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3c
OH


1234
CH
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3d
OH


1235
CH
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3e
OH


1236
CH
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3f
OH


1237
CH
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3g
OH


1238
CH
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3h
OH


1239
CH
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3i
OH


1240
CH
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3j
OH


1241
CH
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3a
OH


1242
CH
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3b
OH


1243
CH
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3c
OH


1244
CH
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3d
OH


1245
CH
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3e
OH


1246
CH
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3f
OH


1247
CH
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3g
OH


1248
CH
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3h
OH


1249
CH
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3i
OH


1250
CH
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3j
OH


1251
CH
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3a
OH


1252
CH
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3b
OH


1253
CH
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3c
OH


1254
CH
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3d
OH


1255
CH
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3e
OH


1256
CH
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3f
OH


1257
CH
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3g
OH


1258
CH
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3h
OH


1259
CH
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3i
OH


1260
CH
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3j
OH


1261
CH
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3a
OH


1262
CH
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3b
OH


1263
CH
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3c
OH


1264
CH
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3d
OH


1265
CH
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3e
OH


1266
CH
MAe
Q1a
a bond
H
a bond
NH
O
NH
T3f
OH


1267
CH
MAe
Q1a
a bond
H
a bond
NH
O
NH
T3g
OH


1268
CH
MAe
Q1a
a bond
H
a bond
NH
O
NH
T3h
OH


1269
CH
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3i
OH


1270
CH
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3j
OH


1271
CH
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3a
OH


1272
CH
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3b
OH


1273
CH
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3c
OH


1274
CH
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3d
OH


1275
CH
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3e
OH


1276
CH
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3f
OH


1277
CH
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3g
OH


1278
CH
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3h
OH


1279
CH
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3i
OH


1280
CH
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3j
OH


1281
CH
MMe
Q1b
a bond
Me
a bond
NH
S
NH
T3a
OH


1282
CH
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3b
OH


1283
CH
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3c
OH


1284
CH
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3d
OH


1285
CH
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3e
OH


1286
CH
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3f
OH


1287
CH
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3g
OH


1288
CH
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3h
OH


1289
CH
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3i
OH


1290
CH
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3j
OH


1291
CH
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3a
OH


1292
CH
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3b
OH


1293
CH
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3c
OH


1294
CH
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3d
OH


1295
CH
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3e
OH


1296
CH
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3f
OH


1297
CH
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3g
OH


1298
CH
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3h
OH


1299
CH
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3i
OH


1300
CH
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3j
OH


1301
CH
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3a
OH


1302
CH
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3b
OH


1303
CH
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3c
OH


1304
CH
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3d
OH


1305
CH
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3e
OH


1306
CH
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3f
OH


1307
CH
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3g
OH


1308
CH
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3h
OH


1309
CH
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3i
OH


1310
CH
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3j
OH


1311
CH
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3a
OH


1312
CH
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3b
OH


1313
CH
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3c
OH


1314
CH
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3d
OH


1315
CH
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3e
OH


1316
CH
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3f
OH


1317
CH
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3g
OH


1318
CH
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3h
OH


1319
CH
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3i
OH


1320
CH
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3j
OH


1321
CH
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3a
OH


1322
CH
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3b
OH


1323
CH
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3c
OH


1324
CH
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3d
OH


1325
CH
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3e
OH


1326
CH
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3f
OH


1327
CH
NNe
Q1b
a bond
H
a bond
NH
S
NH
T3g
OH


1328
CH
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3h
OH


1329
CH
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3i
OH


1330
CH
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3j
OH


1331
CH
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3a
OH


1332
CH
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3b
OH


1333
CH
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3c
OH


1334
CH
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3d
OR


1335
CH
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3e
OH


1336
CH
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3f
OH


1337
CH
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3g
OR


1338
CH
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3h
OR


1339
CH
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3i
OH


1340
CH
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3j
OR


1341
CH
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3a
OH


1342
CH
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3b
OR


1343
CH
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3c
OH


1344
CH
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3d
OH


1345
CH
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3e
OH


1346
CH
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3f
OH


1347
CH
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3g
OH


1348
CH
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3h
OH


1349
CH
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3i
OH


1350
CH
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3j
OH


1351
CH
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3a
OH


1352
CH
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3b
OH


1353
CH
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3c
OH


1354
CH
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3d
OH


1355
CH
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3e
OH


1356
CH
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3f
OH


1357
CH
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3g
OH


1358
CH
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3h
OH


1359
CH
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3i
OH


1360
CH
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3j
OH


1361
CH
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3a
OH


1362
CH
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3b
OH


1363
CH
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3c
OH


1364
CH
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3d
OH


1365
CH
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3e
OH


1366
CH
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3f
OH


1367
CH
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3g
OH


1368
CH
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3h
OH


1369
CH
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3i
OH


1370
CH
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3j
OH


1371
CH
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3a
OH


1372
CH
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3b
OH


1373
CH
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3c
OH


1374
CH
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3d
OH


1375
CH
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3e
OH


1376
CH
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3f
OH


1377
CH
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3g
OH


1378
CH
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3h
OH


1379
CH
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3i
OH


1380
CH
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3j
OH


1381
CH
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3a
OH


1382
CH
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3b
OH


1383
CH
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3c
OH


1384
CH
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3d
OH


1385
CH
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3e
OH


1386
CH
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3f
OH


1387
CH
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3g
OH


1388
CH
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3h
OH


1389
CH
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3i
OH


1390
CH
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3j
OH


1391
CH
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3a
OH


1392
CH
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3b
OH


1393
CH
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3c
OH


1394
CH
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3d
OH


1395
CH
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3e
OH


1396
CH
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3f
OH


1397
CH
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3g
OH


1398
CH
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3h
OH


1399
CH
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3i
OH


1400
CH
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T35
OH


1401
CH
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3a
OH


1402
CH
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3b
OH


1403
CH
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3c
OH


1404
CH
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3d
OH


1405
CH
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3e
OH


1406
CH
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3f
OH


1407
CH
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3g
OH


1408
CH
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3h
OH


1409
CH
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3i
OH


1410
CH
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3j
OH


1411
CH
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3a
OH


1412
CH
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3b
OH


1413
CH
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3c
OH


1414
CH
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3d
OH


1415
CH
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3e
OH


1416
CH
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3f
OH


1417
CH
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3g
OH


1418
CH
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3h
OH


1419
CH
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3i
OH


1420
CH
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3j
OH


1421
CH
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3a
OH


1422
CH
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3b
OH


1423
CH
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3c
OH


1424
CH
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3d
OH


1425
CH
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3e
OH


1426
CH
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3f
OH


1427
CH
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3g
OH


1428
CH
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3h
OH


1429
CH
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3i
OH


1430
CH
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3j
OH


1431
CH
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3a
OH


1432
CH
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3b
OH


1433
CH
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3c
OH


1434
CH
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3d
OH


1435
CH
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3e
OH


1436
CH
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3f
OH


1437
CH
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3g
OH


1438
CH
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3h
OH


1439
CH
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3i
OH


1440
CH
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3j
OH


1441
CH
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3a
OH


1442
CH
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3b
OH


1443
CH
NNe
Q1i
a bond
Me
a bond
NH
S
NH
T3c
OH


1444
CH
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3d
OH


1445
CH
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3e
OH


1446
CH
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3f
OH


1447
CH
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3g
OH


1448
CH
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3h
OH


1449
CH
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3i
OH


1450
CH
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3j
OH


1451
CH
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3a
OH


1452
CH
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3b
OH


1453
CH
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3c
OH


1454
CH
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3d
OH


1455
CH
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3e
OH


1456
CH
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3f
OH


1457
CH
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3g
OH


1458
CH
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3h
OH


1459
CH
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3i
OH


1460
CH
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3j
OH


1461
CH
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3a
OH


1462
CH
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3b
OH


1463
CH
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3c
OH


1464
CH
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3d
OH


1465
CH
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3e
OH


1466
CH
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3f
OH


1467
CH
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3g
OH


1468
CH
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3h
OH


1469
CH
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3i
OH


1470
CH
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T35
OH


1471
CH
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3a
OH


1472
CH
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3b
OH


1473
CH
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3c
OH


1474
CH
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3d
OH


1475
CH
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3e
OH


1476
CH
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3f
OH


1477
CH
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3g
OH


1478
CH
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3h
OH


1479
CH
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3i
OH


1480
CH
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3j
OH


1481
CH
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3a
OH


1482
CH
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3b
OH


1483
CH
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3c
OH


1484
CH
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3d
OH


1485
CH
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3e
OH


1486
CH
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3f
OH


1487
CH
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3g
OH


1488
CH
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3h
OH


1489
CH
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3i
OH


1490
CH
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3j
OH


1491
CH
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3a
OH


1492
CH
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3b
OH


1493
CH
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3c
OH


1494
CH
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3d
OH


1495
CH
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3e
OH


1496
CH
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3f
OH


1497
CH
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3g
OH


1498
CH
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3h
OH


1499
CH
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3i
OH


1500
CH
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3j
OH


1501
CH
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3a
OH


1502
CH
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3b
OH


1503
CH
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3c
OH


1504
CH
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3d
OH


1505
CH
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3e
OH


1506
CH
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3f
OH


1507
CH
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3g
OH


1508
CH
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3h
OH


1509
CH
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3i
OH


1510
CH
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3j
OH


1511
CH
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3a
OH


1512
CH
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3b
OH


1513
CH
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3c
OH


1514
CH
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3d
OH


1515
CH
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3e
OH


1516
CH
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3f
OH


1517
CH
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3g
OH


1518
CH
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3h
OH


1519
CH
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3i
OH


1520
CH
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3j
OH


1521
CH
NMe
Q1j
a bond
Me
a bond
NH
S
NH
T3a
OH


1522
CH
NMe
Q1j
a bond
Me
a bond
NH
S
NH
T3b
OH


1523
CH
NMe
Q1j
a bond
Me
a bond
NH
S
NH
T3c
OH


1524
CH
NMe
Q1j
a bond
Me
a bond
NH
S
NH
T3d
OH


1525
CH
NMe
Q1j
a bond
Me
a bond
NH
S
NH
T3e
OH


1526
CH
NMe
Q1j
a bond
Me
a bond
NH
S
NH
T3f
OH


1527
CH
NMe
Q1j
a bond
Me
a bond
NH
S
NH
T3g
OH


1528
CH
NMe
Q1j
a bond
Me
a bond
NH
S
NH
T3h
OH


1529
CH
NMe
Q1j
a bond
Me
a bond
NH
S
NH
T3i
OH


1530
CH
NMe
Q1j
a bond
Me
a bond
NH
S
NH
T3j
OH


1531
CH
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3a
OH


1532
CH
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3b
OH


1533
CH
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3c
OH


1534
CH
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3d
OH


1535
CH
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3e
OH


1536
CH
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3f
OH


1537
CH
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3g
OH


1538
CH
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3h
OH


1539
CH
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3i
OH


1540
CH
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3j
OH


1541
CH
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3a
OH


1542
CH
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3b
OH


1543
CH
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3c
OH


1544
CH
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3d
OH


1545
CH
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3e
OH


1546
CH
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3f
OH


1547
CH
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3g
OH


1548
CH
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3h
OH


1549
CH
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3i
OH


1550
CH
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3j
OH


1551
CH
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3a
OH


1552
CH
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3b
OH


1553
CH
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3c
OH


1554
CH
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3d
OH


1555
CH
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3e
OH


1556
CH
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3f
OH


1557
CH
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3g
OH


1558
CH
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3h
OH


1559
CH
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3i
OH


1560
CH
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3j
OH


1561
CH
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3a
OH


1562
CH
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3b
OH


1563
CH
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3c
OH


1564
CH
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3d
OH


1565
CH
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3e
OH


1566
CH
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3f
OH


1567
CH
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3g
OH


1568
CH
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3h
OH


1569
CH
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3i
OH


1570
CH
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3j
OH


1571
CH
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3a
OH


1572
CH
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3b
OH


1573
CH
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3c
OH


1574
CH
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3d
OH


1575
CH
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3e
OH


1576
CH
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3f
OH


1577
CH
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3g
OH


1578
CH
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3h
OH


1579
CH
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3i
OH


1580
CH
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3j
OH


1581
CH
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3a
OH


1582
CH
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3b
OH


1583
CH
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3c
OH


1584
CH
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3d
OH


1585
CH
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3e
OH


1586
CH
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3f
OH


1587
CH
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3g
OH


1588
CH
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3h
OH


1589
CH
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3i
OH


1590
CH
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3j
OH


1591
CH
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3a
OH


1592
CH
NMe
Q1j
a bond
H
a bond
NH
O
a bond
T3b
OH


1593
CH
NMe
Q1j
a bond
H
a bond
NH
O
a bond
T3c
OH


1594
CH
NMe
Q1j
a bond
H
a bond
NH
O
a bond
T3d
OH


1595
CH
NMe
Q1j
a bond
H
a bond
NH
O
a bond
T3e
OH


1596
CH
NMe
Q1j
a bond
H
a bond
NH
O
a bond
T3f
OH


1597
CH
NMe
Q1j
a bond
H
a bond
NH
O
a bond
T3g
OH


1598
CH
NMe
Q1j
a bond
H
a bond
NH
O
a bond
T3h
OH


1599
CH
NMe
Q1j
a bond
H
a bond
NH
O
a bond
T3i
OH


1600
CH
NMe
Q1j
a bond
H
a bond
NH
O
a bond
T3j
OH


1601
CH
S
Q1a
a bond
Me
a bond
NH
S
NH
T3a
OH


1602
CH
S
Q1a
a bond
Me
a bond
NH
S
NH
T3b
OH


1603
CH
S
Q1a
a bond
Me
a bond
NH
S
NH
T3c
OH


1604
CH
S
Q1a
a bond
Me
a bond
NH
S
NH
T3d
OH


1605
CH
S
Q1a
a bond
Me
a bond
NH
S
NH
T3e
OH


1606
CH
S
Q1a
a bond
Me
a bond
NH
S
NH
T3f
OH


1607
CH
S
Q1a
a bond
Me
a bond
NH
S
NH
T3g
OH


1608
CH
S
Q1a
a bond
Me
a bond
NH
S
NH
T3h
OH


1609
CH
S
Q1a
a bond
Me
a bond
NH
S
NH
T3i
OH


1610
CH
S
Q1a
a bond
Me
a bond
NH
S
NH
T3j
OH


1611
CH
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3a
OH


1612
CH
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3b
OH


1613
CH
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3c
OH


1614
CH
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3d
OH


1615
CH
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3e
OH


1616
CH
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3f
OH


1617
CH
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3g
OH


1618
CH
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3h
OH


1619
CH
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3i
OH


1620
CH
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3j
OH


1621
CH
S
Q1a
a bond
Me
a bond
NH
O
NH
T3a
OH


1622
CH
S
Q1a
a bond
Me
a bond
NH
O
NH
T3b
OH


1623
CH
S
Q1a
a bond
Me
a bond
NH
O
NH
T3c
OH


1624
CH
S
Q1a
a bond
Me
a bond
NH
O
NH
T3d
OH


1625
CH
S
Q1a
a bond
Me
a bond
NH
O
NH
T3e
OH


1626
CH
S
Q1a
a bond
Me
a bond
NH
O
NH
T3f
OH


1627
CH
S
Q1a
a bond
Me
a bond
NH
O
NH
T3g
OH


1628
CH
S
Q1a
a bond
Me
a bond
NH
O
NH
T3h
OH


1629
CH
S
Q1a
a bond
Me
a bond
NH
O
NH
T3i
OH


1630
CH
S
Q1a
a bond
Me
a bond
NH
O
NH
T3j
OH


1631
CH
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3a
OH


1632
CH
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3b
OH


1633
CH
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3c
OH


1634
CH
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3d
OH


1635
CH
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3e
OH


1636
CH
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3f
OH


1637
CH
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3g
OH


1638
CH
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3h
OH


1639
CH
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3i
OH


1640
CH
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3j
OH


1641
CH
S
Q1a
a bond
H
a bond
NH
S
NH
T3a
OH


1642
CH
S
Q1a
a bond
H
a bond
NH
S
NH
T3b
OH


1643
CH
S
Q1a
a bond
H
a bond
NH
S
NH
T3c
OH


1644
CH
S
Q1a
a bond
H
a bond
NH
S
NH
T3d
OH


1645
CH
S
Q1a
a bond
H
a bond
NH
S
NH
T3e
OH


1646
CH
S
Q1a
a bond
H
a bond
NH
S
NH
T3f
OH


1647
CH
S
Q1a
a bond
H
a bond
NH
S
NH
T3g
OH


1648
CH
S
Q1a
a bond
H
a bond
NH
S
NH
T3h
OH


1649
CH
S
Q1a
a bond
H
a bond
NH
S
NH
T3i
OH


1650
CH
S
Q1a
a bond
H
a bond
NH
S
NH
T3j
OH


1651
CH
S
Q1a
a bond
H
a bond
NH
S
a bond
T3a
OH


1652
CH
S
Q1a
a bond
H
a bond
NH
S
a bond
T3b
OH


1653
CH
S
Q1a
a bond
H
a bond
NH
S
a bond
T3c
OH


1654
CH
S
Q1a
a bond
H
a bond
NH
S
a bond
T3d
OH


1655
CH
S
Q1a
a bond
H
a bond
NH
S
a bond
T3e
OH


1656
CH
S
Q1a
a bond
H
a bond
NH
S
a bond
T3f
OH


1657
CH
S
Q1a
a bond
H
a bond
NH
S
a bond
T3g
OH


1658
CH
S
Q1a
a bond
H
a bond
NH
S
a bond
T3h
OH


1659
CH
S
Q1a
a bond
H
a bond
NH
S
a bond
T3i
OH


1660
CH
S
Q1a
a bond
H
a bond
NH
S
a bond
T3j
OH


1661
CH
S
Q1a
a bond
H
a bond
NH
O
NH
T3a
OH


1662
CH
S
Q1a
a bond
H
a bond
NH
O
NH
T3b
OH


1663
CH
S
Q1a
a bond
H
a bond
NH
O
NH
T3c
OH


1664
CH
S
Q1a
a bond
H
a bond
NH
O
NH
T3d
OH


1665
CH
S
Q1a
a bond
H
a bond
NH
O
NH
T3e
OH


1666
CH
S
Q1a
a bond
H
a bond
NH
O
NH
T3f
OH


1667
CH
S
Q1a
a bond
H
a bond
NH
O
NH
T3g
OH


1668
CH
S
Q1a
a bond
H
a bond
NH
O
NH
T3h
OH


1669
CH
S
Q1a
a bond
H
a bond
NH
O
NH
T3i
OH


1670
CH
S
Q1a
a bond
H
a bond
NH
O
NH
T3j
OH


1671
CH
S
Q1a
a bond
H
a bond
NH
O
a bond
T3a
OH


1672
CH
S
Q1a
a bond
H
a bond
NH
O
a bond
T3b
OH


1673
CH
S
Q1a
a bond
H
a bond
NH
O
a bond
T3c
OH


1674
CH
S
Q1a
a bond
H
a bond
NH
O
a bond
T3d
OH


1675
CH
S
Q1a
a bond
H
a bond
NH
O
a bond
T3e
OH


1676
CH
S
Q1a
a bond
H
a bond
NH
O
a bond
T3f
OH


1677
CH
S
Q1a
a bond
H
a bond
NH
O
a bond
T3g
OH


1678
CH
S
Q1a
a bond
H
a bond
NH
O
a bond
T3h
OH


1679
CH
S
Q1a
a bond
H
a bond
NH
O
a bond
T3i
OH


1680
CH
S
Q1a
a bond
H
a bond
NH
O
a bond
T3j
OH


1681
CH
S
Q1b
a bond
Me
a bond
NH
S
NH
T3a
OH


1682
CH
S
Q1b
a bond
Me
a bond
NH
S
NH
T3b
OH


1683
CH
S
Q1b
a bond
Me
a bond
NH
S
NH
T3c
OH


1684
CH
S
Q1b
a bond
Me
a bond
NH
S
NH
T3d
OH


1685
CH
S
Q1b
a bond
Me
a bond
NH
S
NH
T3e
OH


1686
CH
S
Q1b
a bond
Me
a bond
NH
S
NH
T3f
OH


1687
CH
S
Q1b
a bond
Me
a bond
NH
S
NH
T3g
OH


1688
CH
S
Q1b
a bond
Me
a bond
NH
S
NH
T3h
OH


1689
CH
S
Q1b
a bond
Me
a bond
NH
S
NH
T3i
OH


1690
CH
S
Q1b
a bond
Me
a bond
NH
S
NH
T3j
OH


1691
CH
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3a
OH


1692
CH
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3b
OH


1693
CH
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3c
OH


1694
CH
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3d
OH


1695
CH
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3e
OH


1696
CH
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3f
OH


1697
CH
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3g
OH


1698
CH
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3h
OH


1699
CH
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3i
OH


1700
CH
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3j
OH


1701
CH
S
Q1b
a bond
Me
a bond
NH
O
NH
T3a
OH


1702
CH
S
Q1b
a bond
Me
a bond
NH
O
NH
T3b
OH


1703
CH
S
Q1b
a bond
Me
a bond
NH
O
NH
T3c
OH


1704
CH
S
Q1b
a bond
Me
a bond
NH
O
NH
T3d
OH


1705
CH
S
Q1b
a bond
Me
a bond
NH
O
NH
T3e
OH


1706
CH
S
Q1b
a bond
Me
a bond
NH
O
NH
T3f
OH


1707
CH
S
Q1b
a bond
Me
a bond
NH
O
NH
T3g
OH


1708
CH
S
Q1b
a bond
Me
a bond
NH
O
NH
T3h
OH


1709
CH
S
Q1b
a bond
Me
a bond
NH
O
NH
T3i
OH


1710
CH
S
Q1b
a bond
Me
a bond
NH
O
NH
T3j
OH


1711
CH
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3a
OH


1712
CH
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3b
OH


1713
CH
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3c
OH


1714
CH
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3d
OH


1715
CH
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3e
OH


1716
CH
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3f
OH


1717
CH
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3g
OH


1718
CH
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3h
OH


1719
CH
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3i
OH


1720
CH
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3i
OH


1721
CH
S
Q1b
a bond
H
a bond
NH
S
NH
T3a
OH


1722
CH
S
Q1b
a bond
H
a bond
NH
S
NH
T3b
OH


1723
CH
S
Q1b
a bond
H
a bond
NH
S
NH
T3c
OH


1724
CH
S
Q1b
a bond
H
a bond
NH
S
NH
T3d
OH


1725
CH
S
Q1b
a bond
H
a bond
NH
S
NH
T3e
OH


1726
CH
S
Q1b
a bond
H
a bond
NH
S
NH
T3f
OH


1727
CH
S
Q1b
a bond
H
a bond
NH
S
NH
T3g
OH


1728
CH
S
Q1b
a bond
H
a bond
NH
S
NH
T3h
OH


1729
CH
S
Q1b
a bond
H
a bond
NH
S
NH
T3i
OH


1730
CH
S
Q1b
a bond
H
a bond
NH
S
NH
T3j
OH


1731
CH
S
Q1b
a bond
H
a bond
NH
S
a bond
T3a
OH


1732
CH
S
Q1b
a bond
H
a bond
NH
S
a bond
T3b
OH


1733
CH
S
Q1b
a bond
H
a bond
NH
S
a bond
T3c
OH


1734
CH
S
Q1b
a bond
H
a bond
NH
S
a bond
T3d
OH


1735
CH
S
Q1b
a bond
H
a bond
NH
S
a bond
T3e
OH


1736
CH
S
Q1b
a bond
H
a bond
NH
S
a bond
T3f
OH


1737
CH
S
Q1b
a bond
H
a bond
NH
S
a bond
T3g
OH


1738
CH
S
Q1b
a bond
H
a bond
NH
S
a bond
T3h
OH


1739
CH
S
Q1b
a bond
H
a bond
NH
S
a bond
T3i
OH


1740
CH
S
Q1b
a bond
H
a bond
NH
S
a bond
T3j
OH


1741
CH
S
Q1b
a bond
H
a bond
NH
O
NH
T3a
OH


1742
CH
S
Q1b
a bond
H
a bond
NH
O
NH
T3b
OH


1743
CH
S
Q1b
a bond
H
a bond
NH
O
NH
T3c
OH


1744
CH
S
Q1b
a bond
H
a bond
NH
O
NH
T3d
OH


1745
CH
S
Q1b
a bond
H
a bond
NH
O
NH
T3e
OH


1746
CH
S
Q1b
a bond
H
a bond
NH
O
NH
T3f
OH


1747
CH
S
Q1b
a bond
H
a bond
NH
O
NH
T3g
OH


1748
CH
S
Q1b
a bond
H
a bond
NH
O
NH
T3h
OH


1749
CH
S
Q1b
a bond
H
a bond
NH
O
NH
T3i
OH


1750
CH
S
Q1b
a bond
H
a bond
NH
O
NH
T3j
OH


1751
CH
S
Q1b
a bond
H
a bond
NH
O
a bond
T3a
OH


1752
CH
S
Q1b
a bond
H
a bond
NH
O
a bond
T3b
OH


1753
CH
S
Q1b
a bond
H
a bond
NH
O
a bond
T3c
OH


1754
CH
S
Q1b
a bond
H
a bond
NH
O
a bond
T3d
OH


1755
CH
S
Q1b
a bond
H
a bond
NH
O
a bond
T3e
OH


1756
CH
S
Q1b
a bond
H
a bond
NH
O
a bond
T3f
OH


1757
CH
S
Q1b
a bond
H
a bond
NH
O
a bond
T3g
OH


1758
CH
S
Q1b
a bond
H
a bond
NH
O
a bond
T3h
OH


1759
CH
S
Q1b
a bond
H
a bond
NH
O
a bond
T3i
OH


1760
CH
S
Q1b
a bond
H
a bond
NH
O
a bond
T3j
OH


1761
CH
S
Q1c
a bond
Me
a bond
NH
S
NH
T3a
OH


1762
CH
S
Q1c
a bond
Me
a bond
NH
S
NH
T3b
OH


1763
CH
S
Q1c
a bond
Me
a bond
NH
S
NH
T3c
OH


1764
CH
S
Q1c
a bond
Me
a bond
NH
S
NH
T3d
OH


1765
CH
S
Q1c
a bond
Me
a bond
NH
S
NH
T3e
OH


1766
CH
S
Q1c
a bond
Me
a bond
NH
S
NH
T3f
OH


1767
CH
S
Q1c
a bond
Me
a bond
NH
S
NH
T3g
OH


1768
CH
S
Q1c
a bond
Me
a bond
NH
S
NH
T3h
OH


1769
CH
S
Q1c
a bond
Me
a bond
NH
S
NH
T3i
OH


1770
CH
S
Q1c
a bond
Me
a bond
NH
S
NH
T3j
OH


1771
CH
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3a
OH


1772
CH
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3b
OH


1773
CH
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3c
OH


1774
CH
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3d
OH


1775
CH
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3e
OH


1776
CH
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3f
OH


1777
CH
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3g
OH


1778
CH
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3h
OH


1779
CH
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3i
OH


1780
CH
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3j
OH


1781
CH
S
Q1c
a bond
Me
a bond
NH
O
NH
T3a
OH


1782
CH
S
Q1c
a bond
Me
a bond
NH
O
NH
T3b
OH


1783
CH
S
Q1c
a bond
Me
a bond
NH
O
NH
T3c
OH


1784
CH
S
Q1c
a bond
Me
a bond
NH
O
NH
T3d
OH


1785
CH
S
Q1c
a bond
Me
a bond
NH
O
NH
T3e
OH


1786
CH
S
Q1c
a bond
Me
a bond
NH
O
NH
T3f
OH


1787
CH
S
Q1c
a bond
Me
a bond
NH
O
NH
T3g
OH


1788
CH
S
Q1c
a bond
Me
a bond
NH
O
NH
T3h
OH


1789
CH
S
Q1c
a bond
Me
a bond
NH
O
NH
T3i
OH


1790
CH
S
Q1c
a bond
Me
a bond
NH
O
NH
T3j
OH


1791
CH
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3a
OH


1792
CH
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3b
OH


1793
CH
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3c
OH


1794
CH
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3d
OH


1795
CH
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3e
OH


1796
CH
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3f
OH


1797
CH
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3g
OH


1798
CH
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3h
OH


1799
CH
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3i
OH


1800
CH
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3j
OH


1801
CH
S
Q1c
a bond
H
a bond
NH
S
NH
T3a
OH


1802
CH
S
Q1c
a bond
H
a bond
NH
S
NH
T3b
OH


1803
CH
S
Q1c
a bond
H
a bond
NH
S
NH
T3c
OH


1804
CH
S
Q1c
a bond
H
a bond
NH
S
NH
T3d
OH


1805
CH
S
Q1c
a bond
R
a bond
NH
S
NH
T3e
OH


1806
CH
S
Q1c
a bond
H
a bond
NH
S
NH
T3f
OH


1807
CH
S
Q1c
a bond
H
a bond
NH
S
NH
T3g
OH


1808
CH
S
Q1c
a bond
H
a bond
NH
S
NH
T3h
OH


1809
CH
S
Q1c
a bond
H
a bond
NH
S
NH
T3i
OH


1810
CH
S
Q1c
a bond
H
a bond
NH
S
NH
T3j
OH


1811
CH
S
Q1c
a bond
H
a bond
NH
S
a bond
T3a
OH


1812
CH
S
Q1c
a bond
H
a bond
NH
S
a bond
T3b
OH


1813
CH
S
Q1c
a bond
H
a bond
NH
S
a bond
T3c
OH


1814
CH
S
Q1c
a bond
H
a bond
NH
S
a bond
T3d
OH


1815
CH
S
Q1c
a bond
H
a bond
NH
S
a bond
T3e
OH


1816
CH
S
Q1c
a bond
H
a bond
NH
S
a bond
T3f
OH


1817
CH
S
Q1c
a bond
H
a bond
NH
S
a bond
T3g
OH


1818
CH
S
Q1c
a bond
H
a bond
NH
S
a bond
T3h
OH


1819
CH
S
Q1c
a bond
H
a bond
NH
S
a bond
T3i
OH


1820
CH
S
Q1c
a bond
H
a bond
NH
S
a bond
T3j
OH


1821
CH
S
Q1c
a bond
H
a bond
NH
O
NH
T3a
OH


1822
CH
S
Q1c
a bond
H
a bond
NH
O
NH
T3b
OH


1823
CH
S
Q1c
a bond
H
a bond
NH
O
NH
T3c
OH


1824
CH
S
Q1c
a bond
H
a bond
NH
O
NH
T3d
OH


1825
CH
S
Q1c
a bond
H
a bond
NH
O
NH
T3e
OH


1826
CH
S
Q1c
a bond
H
a bond
NH
O
NH
T3f
OH


1827
CH
S
Q1c
a bond
H
a bond
NH
O
NH
T3g
OH


1828
CH
S
Q1c
a bond
H
a bond
NH
O
NH
T3h
OH


1829
CH
S
Q1c
a bond
H
a bond
NH
O
NH
T3i
OH


1830
CH
S
Q1c
a bond
H
a bond
NH
O
NH
T3j
OH


1831
CH
S
Q1c
a bond
H
a bond
NH
O
a bond
T3a
OH


1832
CH
S
Q1c
a bond
H
a bond
NH
O
a bond
T3b
OH


1833
CH
S
Q1c
a bond
H
a bond
NH
O
a bond
T3c
OH


1834
CH
S
Q1c
a bond
H
a bond
NH
O
a bond
T3d
OH


1835
CH
S
Q1c
a bond
H
a bond
NH
O
a bond
T3e
OH


1836
CH
S
Q1c
a bond
H
a bond
NH
O
a bond
T3f
OH


1837
CH
S
Q1c
a bond
H
a bond
NH
O
a bond
T3g
OH


1838
CH
S
Q1c
a bond
H
a bond
NH
O
a bond
T3h
OH


1839
CH
S
Q1c
a bond
H
a bond
NH
O
a bond
T3i
OH


1840
CH
S
Q1c
a bond
H
a bond
NH
O
a bond
T3j
OH


1841
CH
S
Q1i
a bond
Me
a bond
NH
S
NH
T3a
OH


1842
CH
S
Q1i
a bond
Me
a bond
NH
S
NH
T3b
OH


1843
CH
S
Q1i
a bond
Me
a bond
NH
S
NH
T3c
OH


1844
CH
S
Q1i
a bond
Me
a bond
NH
S
NH
T3d
OH


1845
CH
S
Q1i
a bond
Me
a bond
NH
S
NH
T3e
OH


1846
CH
S
Q1i
a bond
Me
a bond
NH
S
NH
T3f
OH


1847
CH
S
Q1i
a bond
Me
a bond
NH
S
NH
T3g
OH


1848
CH
S
Q1i
a bond
Me
a bond
NH
S
NH
T3h
OH


1849
CH
S
Q1i
a bond
Me
a bond
NH
S
NH
T3i
OH


1850
CH
S
Q1i
a bond
Me
a bond
NH
S
NH
T3j
OH


1851
CH
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3a
OH


1852
CH
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3b
OH


1853
CH
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3c
OH


1854
CH
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3d
OH


1855
CH
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3e
OH


1856
CH
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3f
OH


1857
CH
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3g
OH


1858
CH
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3h
OH


1859
CH
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3i
OH


1860
CH
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3j
OH


1861
CH
S
Q1i
a bond
Me
a bond
NH
O
NH
T3a
OH


1862
CH
S
Q1i
a bond
Me
a bond
NH
O
NH
T3b
OH


1863
CH
S
Q1i
a bond
Me
a bond
NH
O
NH
T3c
OH


1864
CH
S
Q1i
a bond
Me
a bond
NH
O
NH
T3d
OH


1865
CH
S
Q1i
a bond
Me
a bond
NH
O
NH
T3e
OH


1866
CH
S
Q1i
a bond
Me
a bond
NH
O
NH
T3f
OH


1867
CH
S
Q1i
a bond
Me
a bond
NH
O
NH
T3g
OH


1868
CH
S
Q1i
a bond
Me
a bond
NH
O
NH
T3h
OH


1869
CH
S
Q1i
a bond
Me
a bond
NH
O
NH
T3i
OH


1870
CH
S
Q1i
a bond
Me
a bond
NH
O
NH
T3j
OH


1871
CH
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3a
OH


1872
CH
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3b
OH


1873
CH
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3c
OH


1874
CH
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3d
OH


1875
CH
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3e
OH


1876
CH
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3f
OH


1877
CH
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3g
OH


1878
CH
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3h
OH


1879
CH
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3i
OH


1880
CH
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3j
OH


1881
CH
S
Q1i
a bond
H
a bond
NH
S
NH
T3a
OH


1882
CH
S
Q1i
a bond
H
a bond
NH
S
NH
T3b
OH


1883
CH
S
Q1i
a bond
H
a bond
NH
S
NH
T3c
OH


1884
CH
S
Q1i
a bond
H
a bond
NH
S
NH
T3d
OH


1885
CH
S
Q1i
a bond
H
a bond
NH
S
NH
T3e
OH


1886
CH
S
Q1i
a bond
H
a bond
NH
S
NH
T3f
OH


1887
CH
S
Q1i
a bond
H
a bond
NH
S
NH
T3g
OH


1888
CH
S
Q1i
a bond
H
a bond
NH
S
NH
T3h
OH


1889
CH
S
Q1i
a bond
H
a bond
NH
S
NH
T3i
OH


1890
CH
S
Q1i
a bond
H
a bond
NH
S
NH
T3j
OH


1891
CH
S
Q1i
a bond
H
a bond
NH
S
a bond
T3a
OH


1892
CH
S
Q1i
a bond
H
a bond
NH
S
a bond
T3b
OH


1893
CH
S
Q1i
a bond
H
a bond
NH
S
a bond
T3c
OH


1894
CH
S
Q1i
a bond
H
a bond
NH
S
a bond
T3d
OH


1895
CH
S
Q1i
a bond
H
a bond
NH
S
a bond
T3e
OH


1896
CH
S
Q1i
a bond
H
a bond
NH
S
a bond
T3f
OH


1897
CH
S
Q1i
a bond
H
a bond
NH
S
a bond
T3g
OH


1898
CH
S
Q1i
a bond
H
a bond
NH
S
a bond
T3h
OH


1899
CH
S
Q1i
a bond
H
a bond
NH
S
a bond
T3i
OH


1900
CH
S
Q1i
a bond
H
a bond
NH
S
a bond
T3j
OH


1901
CH
S
Q1i
a bond
H
a bond
NH
O
NH
T3a
OH


1902
CH
S
Q1i
a bond
H
a bond
NH
O
NH
T3b
OH


1903
CH
S
Q1i
a bond
H
a bond
NH
O
NH
T3c
OH


1904
CH
S
Q1i
a bond
H
a bond
NH
O
NH
T3d
OH


1905
CH
S
Q1i
a bond
H
a bond
NH
O
NH
T3e
OH


1906
CH
S
Q1i
a bond
H
a bond
NH
O
NH
T3f
OH


1907
CH
S
Q1i
a bond
H
a bond
NH
O
NH
T3g
OH


1908
CH
S
Q1i
a bond
H
a bond
NH
O
NH
T3h
OH


1909
CH
S
Q1i
a bond
H
a bond
NH
O
NH
T3i
OH


1910
CH
S
Q1i
a bond
H
a bond
NH
O
NH
T3j
OH


1911
CH
S
Q1i
a bond
H
a bond
NH
O
a bond
T3a
OH


1912
CH
S
Q1i
a bond
H
a bond
NH
O
a bond
T3b
OH


1913
CH
S
Q1i
a bond
H
a bond
NH
O
a bond
T3c
OH


1914
CH
S
Q1i
a bond
H
a bond
NH
O
a bond
T3d
OH


1915
CH
S
Q1i
a bond
H
a bond
NH
O
a bond
T3e
OH


1916
CH
S
Q1i
a bond
H
a bond
NH
O
a bond
T3f
OH


1917
CH
S
Q1i
a bond
H
a bond
NH
O
a bond
T3g
OH


1918
CH
S
Q1i
a bond
H
a bond
NH
O
a bond
T3h
OH


1919
CH
S
Q1i
a bond
H
a bond
NH
O
a bond
T3i
OH


1920
CH
S
Q1i
a bond
H
a bond
NH
O
a bond
T3j0H


1921
CH
S
Q1j
a bond
Me
a bond
NH
S
NH
T3a
OH


1922
CH
S
Q1j
a bond
Me
a bond
NH
S
NH
T3b
OH


1923
CH
S
Q1j
a bond
Me
a bond
NH
S
NH
T3c
OH


1924
CH
S
Q1j
a bond
Me
a bond
NH
S
NH
T3d
OH


1925
CH
S
Q1j
a bond
Me
a bond
NH
S
NH
T3e
OH


1926
CH
S
Q1j
a bond
Me
a bond
NH
S
NH
T3f
OH


1927
CH
S
Q1j
a bond
Me
a bond
NH
S
NH
T3g
OH


1928
CH
S
Q1j
a bond
Me
a bond
NH
S
NH
T3h
OH


1929
CH
S
Q1j
a bond
Me
a bond
NH
S
NH
T3i
OH


1930
CH
S
Q1j
a bond
Me
a bond
NH
S
NH
T3j
OH


1931
CH
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3a
OH


1932
CH
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3b
OH


1933
CH
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3c
OH


1934
CH
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3d
OH


1935
CH
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3e
OH


1936
CH
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3f
OH


1937
CH
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3g
OH


1938
CH
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3h
OH


1939
CH
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3i
OH


1940
CH
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3j
OH


1941
CH
S
Q1j
a bond
Me
a bond
NH
O
NH
T3a
OH


1942
CH
S
Q1j
a bond
Me
a bond
NH
O
NH
T3b
OH


1943
CH
S
Q1j
a bond
Me
a bond
NH
O
NH
T3c
OH


1944
CH
S
Q1j
a bond
Me
a bond
NH
O
NH
T3d
OH


1945
CH
S
Q1j
a bond
Me
a bond
NH
O
NH
T3e
OH


1946
CH
S
Q1j
a bond
Me
a bond
NH
O
NH
T3f
OH


1947
CH
S
Q1j
a bond
Me
a bond
NH
O
NH
T3g
OH


1948
CH
S
Q1j
a bond
Me
a bond
NH
O
NH
T3h
OH


1949
CH
S
Q1j
a bond
Me
a bond
NH
O
NH
T3i
OH


1950
CH
S
Q1j
a bond
Me
a bond
NH
O
NH
T3j
OH


1951
CH
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3a
OH


1952
CH
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3b
OH


1953
CH
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3c
OH


1954
CH
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3d
OH


1955
CH
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3e
OH


1956
CH
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3f
OH


1957
CH
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3g
OH


1958
CH
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3h
OH


1959
CH
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3i
OH


1960
CH
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3j
OH


1961
CH
S
Q1j
a bond
H
a bond
NH
S
NH
T3a
OH


1962
CH
S
Q1j
a bond
H
a bond
NH
S
NH
T3b
OH


1963
CH
S
Q1j
a bond
H
a bond
NH
S
NH
T3c
OH


1964
CH
S
Q1j
a bond
H
a bond
NH
S
NH
T3d
OH


1965
CH
S
Q1j
a bond
H
a bond
NH
S
NH
T3e
OH


1966
CH
S
Q1j
a bond
H
a bond
NH
S
NH
T3f
OH


1967
CH
S
Q1j
a bond
H
a bond
NH
S
NH
T3g
OH


1968
CH
S
Q1j
a bond
H
a bond
NH
S
NH
T3h
OH


1969
CH
S
Q1j
a bond
H
a bond
NH
S
NH
T3i
OH


1970
CH
S
Q1j
a bond
H
a bond
NH
S
NH
T3j
OH


1971
CH
S
Q1j
a bond
H
a bond
NH
S
a bond
T3a
OH


1972
CH
S
Q1j
a bond
H
a bond
NH
S
a bond
T3b
OH


1973
CH
S
Q1j
a bond
H
a bond
NH
S
a bond
T3c
OH


1974
CH
S
Q1j
a bond
H
a bond
NH
S
a bond
T3d
OH


1975
CH
S
Q1j
a bond
H
a bond
NH
S
a bond
T3e
OH


1976
CH
S
Q1j
a bond
H
a bond
NH
S
a bond
T3f
OH


1977
CH
S
Q1j
a bond
H
a bond
NH
S
a bond
T3g
OH


1978
CH
S
Q1j
a bond
H
a bond
NH
S
a bond
T3h
OH


1979
CH
S
Q1j
a bond
H
a bond
NH
S
a bond
T3i
OH


1980
CH
S
Q1j
a bond
H
a bond
NH
S
a bond
T3j
OH


1981
CH
S
Q1j
a bond
H
a bond
NH
O
NH
T3a
OH


1982
CH
S
Q1j
a bond
H
a bond
NH
O
NH
T3b
OH


1983
CH
S
Q1j
a bond
H
a bond
NH
O
NH
T3c
OH


1984
CH
S
Q1j
a bond
H
a bond
NH
O
NH
T3d
OH


1985
CH
S
Q1j
a bond
H
a bond
NH
O
NH
T3e
OH


1986
CH
S
Q1j
a bond
H
a bond
NH
O
NH
T3f
OH


1987
CH
S
Q1j
a bond
H
a bond
NH
O
NH
T3g
OH


1988
CH
S
Q1j
a bond
H
a bond
NH
O
NH
T3h
OH


1989
CH
S
Q1j
a bond
H
a bond
NH
O
NH
T3i
OH


1990
CH
S
Q1j
a bond
H
a bond
NH
O
NH
T3j
OH


1991
CH
S
Q1j
a bond
H
a bond
NH
O
a bond
T3a
OH


1992
CH
S
Q1j
a bond
H
a bond
NH
O
a bond
T3b
OH


1993
CH
S
Q1j
a bond
H
a bond
NH
O
a bond
T3c
OH


1994
CH
S
Q1j
a bond
H
a bond
NH
O
a bond
T3d
OH


1995
CH
S
Q1j
a bond
H
a bond
NH
O
a bond
T3e
OH


1996
CH
S
Q1j
a bond
H
a bond
NH
O
a bond
T3f
OH


1997
CH
S
Q1j
a bond
H
a bond
NH
O
a bond
T3g
OH


1998
CH
S
Q1j
a bond
H
a bond
NH
O
a bond
T3h
OH


1999
CH
S
Q1j
a bond
H
a bond
NH
O
a bond
T3i
OH


2000
CH
S
Q1j
a bond
H
a bond
NH
O
a bond
T3j
OH


2001
CH
O
Q1a
a bond
Me
a bond
NH
S
NH
T3a
OH


2002
CH
O
Q1a
a bond
Me
a bond
NH
S
NH
T3b
OH


2003
CH
O
Q1a
a bond
Me
a bond
NH
S
NH
T3c
OH


2004
CH
O
Q1a
a bond
Me
a bond
NH
S
NH
T3d
OH


2005
CH
O
Q1a
a bond
Me
a bond
NH
S
NH
T3e
OH


2006
CH
O
Q1a
a bond
Me
a bond
NH
S
NH
T3f
OH


2007
CH
O
Q1a
a bond
Me
a bond
NH
S
NH
T3g
OH


2008
CH
O
Q1a
a bond
Me
a bond
NH
S
NH
T3h
OH


2009
CH
O
Q1a
a bond
Me
a bond
NH
S
NH
T3i
OH


2010
CH
O
Q1a
a bond
Me
a bond
NH
S
NH
T3j
OH


2011
CH
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3a
OH


2012
CH
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3b
OH


2013
CH
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3c
OH


2014
CH
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3d
OH


2015
CH
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3e
OH


2016
CH
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3f
OH


2017
CH
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3g
OH


2018
CH
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3h
OH


2019
CH
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3i
OH


2020
CH
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3j
OH


2021
CH
O
Q1a
a bond
Me
a bond
NH
O
NH
T3a
OH


2022
CH
O
Q1a
a bond
Me
a bond
NH
O
NH
T3b
OH


2023
CH
O
Q1a
a bond
Me
a bond
NH
O
NH
T3c
OH


2024
CH
O
Q1a
a bond
Me
a bond
NH
O
NH
T3d
OH


2025
CH
O
Q1a
a bond
Me
a bond
NH
O
NH
T3e
OH


2026
CH
O
Q1a
a bond
Me
a bond
NH
O
NH
T3f
OH


2027
CH
O
Q1a
a bond
Me
a bond
NH
O
NH
T3g
OH


2028
CH
O
Q1a
a bond
Me
a bond
NH
O
NH
T3h
OH


2029
CH
O
Q1a
a bond
Me
a bond
NH
O
NH
T3i
OH


2030
CH
O
Q1a
a bond
Me
a bond
NH
O
NH
T3j
OH


2031
CH
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3a
OH


2032
CH
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3b
OH


2033
CH
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3c
OH


2034
CH
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3d
OH


2035
CH
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3e
OH


2036
CH
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3f
OH


2037
CH
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3g
OH


2038
CH
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3h
OH


2039
CH
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3i
Oli


2040
CH
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3j
OH


2041
CH
O
Q1a
a bond
H
a bond
NH
S
NH
T3a
OH


2042
CH
O
Q1a
a bond
H
a bond
NH
S
NH
T3b
OH


2043
CH
O
Q1a
a bond
H
a bond
NH
S
NH
T3c
OH


2044
CH
O
Q1a
a bond
H
a bond
NH
S
NH
T3d
OH


2045
CH
O
Q1a
a bond
H
a bond
NH
S
NH
T3e
OH


2046
CH
O
Q1a
a bond
H
a bond
NH
S
NH
T3f
OH


2047
CH
O
Q1a
a bond
H
a bond
NH
S
NH
T3g
OH


2048
CH
O
Q1a
a bond
H
a bond
NH
S
NH
T3h
OH


2049
CH
O
Q1a
a bond
H
a bond
NH
S
NH
T3i
OH


2050
CH
O
Q1a
a bond
H
a bond
NH
S
NH
T3j
OH


2051
CH
O
Q1a
a bond
H
a bond
NH
S
a bond
T3a
OH


2052
CH
O
Q1a
a bond
H
a bond
NH
S
a bond
T3b
OH


2053
CH
O
Q1a
a bond
H
a bond
NH
S
a bond
T3c
OH


2054
CH
O
Q1a
a bond
H
a bond
NH
S
a bond
T3d
OH


2055
CH
O
Q1a
a bond
H
a bond
NH
S
a bond
T3e
OH


2056
CH
O
Q1a
a bond
H
a bond
NH
S
a bond
T3f
OH


2057
CH
O
Q1a
a bond
H
a bond
NH
S
a bond
T3g
OH


2058
CH
O
Q1a
a bond
H
a bond
NH
S
a bond
T3h
OH


2059
CH
O
Q1a
a bond
H
a bond
NH
S
a bond
T3i
OH


2060
CH
O
Q1a
a bond
H
a bond
NH
S
a bond
T3j
OH


2061
CH
O
Q1a
a bond
H
a bond
NH
O
NH
T3a
OH


2062
CH
O
Q1a
a bond
H
a bond
NH
O
NH
T3b
OH


2063
CH
O
Q1a
a bond
H
a bond
NH
O
NH
T3c
OH


2064
CH
O
Q1a
a bond
H
a bond
NH
O
NH
T3d
OH


2065
CH
O
Q1a
a bond
H
a bond
NH
O
NH
T3e
OH


2066
CH
O
Q1a
a bond
H
a bond
NH
O
NH
T3f
OH


2067
CH
O
Q1a
a bond
H
a bond
NH
O
NH
T3g
OH


2068
CH
O
Q1a
a bond
H
a bond
NH
O
NH
T3h
OH


2069
CH
O
Q1a
a bond
H
a bond
NH
O
NH
T3i
OH


2070
CH
O
Q1a
a bond
H
a bond
NH
O
NH
T3j
OH


2071
CH
O
Q1a
a bond
H
a bond
NH
O
a bond
T3a
OH


2072
CH
O
Q1a
a bond
H
a bond
NH
O
a bond
T3b
OH


2073
CH
O
Q1a
a bond
H
a bond
NH
O
a bond
T3c
OH


2074
CH
O
Q1a
a bond
H
a bond
NH
O
a bond
T3d
OH


2075
CH
O
Q1a
a bond
H
a bond
NH
O
a bond
T3e
OH


2076
CH
O
Q1a
a bond
H
a bond
NH
O
a bond
T3f
OH


2077
CH
O
Q1a
a bond
H
a bond
NH
O
a bond
T3g
OH


2078
CH
O
Q1a
a bond
H
a bond
NH
O
a bond
T3h
OH


2079
CH
O
Q1a
a bond
H
a bond
NH
O
a bond
T3i
OH


2080
CH
O
Q1a
a bond
H
a bond
NH
O
a bond
T3j
OH


2081
CH
O
Q1b
a bond
Me
a bond
NH
S
NH
T3a
OH


2082
CH
O
Q1b
a bond
Me
a bond
NH
S
NH
T3b
OH


2083
CH
O
Q1b
a bond
Me
a bond
NH
S
NH
T3c
OH


2084
CH
O
Q1b
a bond
Me
a bond
NH
S
NH
T3d
OH


2085
CH
O
Q1b
a bond
Me
a bond
NH
S
NH
T3e
OH


2086
CH
O
Q1b
a bond
Me
a bond
NH
S
NH
T3f
OH


2087
CH
O
Q1b
a bond
Me
a bond
NH
S
NH
T3g
OH


2088
CH
O
Q1b
a bond
Me
a bond
NH
S
NH
T3h
OH


2089
CH
O
Q1b
a bond
Me
a bond
NH
S
NH
T3i
OH


2090
CH
O
Q1b
a bond
Me
a bond
NH
S
NH
T3j
OH


2091
CH
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3a
OH


2092
CH
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3b
OH


2093
CH
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3c
OH


2094
CH
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3d
OH


2095
CH
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3e
OH


2096
CH
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3f
OH


2097
CH
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3g
OH


2098
CH
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3h
OH


2099
CH
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3i
OH


2100
CH
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3j
OH


2101
CH
O
Q1b
a bond
Me
a bond
NH
O
NH
T3a
OH


2102
CH
O
Q1b
a bond
Me
a bond
NH
O
NH
T3b
OH


2103
CH
O
Q1b
a bond
Me
a bond
NH
O
NH
T3c
OH


2104
CH
O
Q1b
a bond
Me
a bond
NH
O
NH
T3d
OH


2105
CH
O
Q1b
a bond
Me
a bond
NH
O
NH
T3e
OH


2106
CH
O
Q1b
a bond
Me
a bond
NH
O
NH
T3f
OH


2107
CH
O
Q1b
a bond
Me
a bond
NH
O
NH
T3g
OH


2108
CH
O
Q1b
a bond
Me
a bond
NH
O
NH
T3h
OH


2109
CH
O
Q1b
a bond
Me
a bond
NH
O
NH
T3i
OH


2110
CH
O
Q1b
a bond
Me
a bond
NH
O
NH
T3j
OH


2111
CH
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3a
OH


2112
CH
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3b
OH


2113
CH
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3c
OH


2114
CH
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3d
OH


2115
CH
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3e
OH


2116
CH
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3f
OH


2117
CH
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3g
OH


2118
CH
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3h
OH


2119
CH
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3i
OH


2120
CH
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3j
OH


2121
CH
O
Q1b
a bond
H
a bond
NH
S
NH
T3a
OH


2122
CH
O
Q1b
a bond
H
a bond
NH
S
NH
T3b
OH


2123
CH
O
Q1b
a bond
H
a bond
NH
S
NH
T3c
OH


2124
CH
O
Q1b
a bond
H
a bond
NH
S
NH
T3d
OH


2125
CH
O
Q1b
a bond
H
a bond
NH
S
NH
T3e
OH


2126
CH
O
Q1b
a bond
H
a bond
NH
S
NH
T3f
OH


2127
CH
O
Q1b
a bond
H
a bond
NH
S
NH
T3g
OH


2128
CH
O
Q1b
a bond
H
a bond
NH
S
NH
T3h
OH


2129
CH
O
Q1b
a bond
H
a bond
NH
S
NH
T3i
OH


2130
CH
O
Q1b
a bond
H
a bond
NH
S
NH
T3j
OH


2131
CH
O
Q1b
a bond
H
a bond
NH
S
a bond
T3a
OH


2132
CH
O
Q1b
a bond
H
a bond
NH
S
a bond
T3b
OH


2133
CH
O
Q1b
a bond
H
a bond
NH
S
a bond
T3c
OH


2134
CH
O
Q1b
a bond
H
a bond
NH
S
a bond
T3d
OH


2135
CH
O
Q1b
a bond
H
a bond
NH
S
a bond
T3e
OH


2136
CH
O
Q1b
a bond
H
a bond
NH
S
a bond
T3f
OH


2137
CH
O
Q1b
a bond
H
a bond
NH
S
a bond
T3g
OH


2138
CH
O
Q1b
a bond
H
a bond
NH
S
a bond
T3h
OH


2139
CH
O
Q1b
a bond
H
a bond
NH
S
a bond
T3i
OH


2140
CH
O
Q1b
a bond
H
a bond
NH
S
a bond
T3j
OH


2141
CH
O
Q1b
a bond
H
a bond
NH
O
NH
T3a
OH


2142
CH
O
Q1b
a bond
H
a bond
NH
O
NH
T3b
OH


2143
CH
O
Q1b
a bond
H
a bond
NH
O
NH
T3c
OH


2144
CH
O
Q1b
a bond
H
a bond
NH
O
NH
T3d
OH


2145
CH
O
Q1b
a bond
H
a bond
NH
O
NH
T3e
OH


2146
CH
O
Q1b
a bond
H
a bond
NH
O
NH
T3f
OH


2147
CH
O
Q1b
a bond
H
a bond
NH
O
NH
T3g
OH


2148
CH
O
Q1b
a bond
H
a bond
NH
O
NH
T3h
OH


2149
CH
O
Q1b
a bond
H
a bond
NH
O
NH
T3i
OH


2150
CH
O
Q1b
a bond
H
a bond
NH
O
NH
T3j
OH


2151
CH
O
Q1b
a bond
H
a bond
NH
O
a bond
T3a
OH


2152
CH
O
Q1b
a bond
H
a bond
NH
O
a bond
T3b
OH


2153
CH
O
Q1b
a bond
H
a bond
NH
O
a bond
T3c
OH


2154
CH
O
Q1b
a bond
H
a bond
NH
O
a bond
T3d
OH


2155
CH
O
Q1b
a bond
H
a bond
NH
O
a bond
T3e
OH


2156
CH
O
Q1b
a bond
H
a bond
NH
O
a bond
T3f
OH


2157
CH
O
Q1b
a bond
H
a bond
NH
O
a bond
T3g
OH


2158
CH
O
Q1b
a bond
H
a bond
NH
O
a bond
T3h
OH


2159
CH
O
Q1b
a bond
H
a bond
NH
O
a bond
T3i
OH


2160
CH
O
Q1b
a bond
H
a bond
NH
O
a bond
T3j
OH


2161
CH
O
Q1c
a bond
Me
a bond
NH
S
NH
T3a
OH


2162
CH
O
Q1c
a bond
Me
a bond
NH
S
NH
T3b
OH


2163
CH
O
Q1c
a bond
Me
a bond
NH
S
NH
T3c
OH


2164
CH
O
Q1c
a bond
Me
a bond
NH
S
NH
T3d
OH


2165
CH
O
Q1c
a bond
Me
a bond
NH
S
NH
T3e
OH


2166
CH
O
Q1c
a bond
Me
a bond
NH
S
NH
T3f
OH


2167
CH
O
Q1c
a bond
Me
a bond
NH
S
NH
T3g
OH


2168
CH
O
Q1c
a bond
Me
a bond
NH
S
NH
T3h
OH


2169
CH
O
Q1c
a bond
Me
a bond
NH
S
NH
T3i
OH


2170
CH
O
Q1c
a bond
Me
a bond
NH
S
NH
T3j
OH


2171
CH
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3a
OH


2172
CH
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3b
OH


2173
CH
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3c
OH


2174
CH
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3d
OH


2175
CH
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3e
OH


2176
CH
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3f
OH


2177
CH
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3g
OH


2178
CH
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3h
OH


2179
CH
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3i
OH


2180
CH
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3j
OH


2181
CH
O
Q1c
a bond
Me
a bond
NH
O
NH
T3a
OH


2182
CH
O
Q1c
a bond
Me
a bond
NH
O
NH
T3b
OH


2183
CH
O
Q1c
a bond
Me
a bond
NH
O
NH
T3c
OH


2184
CH
O
Q1c
a bond
Me
a bond
NH
O
NH
T3d
OH


2185
CH
O
Q1c
a bond
Me
a bond
NH
O
NH
T3e
OH


2186
CH
O
Q1c
a bond
Me
a bond
NH
O
NH
T3f
OH


2187
CH
O
Q1c
a bond
Me
a bond
NH
O
NH
T3g
OH


2188
CH
O
Q1c
a bond
Me
a bond
NH
O
NH
T3h
OH


2189
CH
O
Q1c
a bond
Me
a bond
NH
O
NH
T3i
OH


2190
CH
O
Q1c
a bond
Me
a bond
NH
O
NH
T3j
OH


2191
CH
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3a
OH


2192
CH
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3b
OH


2193
CH
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3c
OH


2194
CH
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3d
OH


2195
CH
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3e
OH


2196
CH
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3f
OH


2197
CH
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3g
OH


2198
CH
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3h
OH


2199
CH
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3i
OH


2200
CH
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3j
OH


2201
CH
O
Q1c
a bond
H
a bond
NH
S
NH
T3a
OH


2202
CH
O
Q1c
a bond
H
a bond
NH
S
NH
T3b
OH


2203
CH
O
Q1c
a bond
H
a bond
NH
S
NH
T3c
OH


2204
CH
O
Q1c
a bond
H
a bond
NH
S
NH
T3d
OH


2205
CH
O
Q1c
a bond
H
a bond
NH
S
NH
T3e
OH


2206
CH
O
Q1c
a bond
H
a bond
NH
S
NH
T3f
OH


2207
CH
O
Q1c
a bond
H
a bond
NH
S
NH
T3g
OH


2208
CH
O
Q1c
a bond
H
a bond
NH
S
NH
T3h
OH


2209
CH
O
Q1c
a bond
H
a bond
NH
S
NH
T3i
OH


2210
CH
O
Q1c
a bond
H
a bond
NH
S
NH
T3j
OH


2211
CH
O
Q1c
a bond
H
a bond
NH
S
a bond
T3a
OH


2212
CH
O
Q1c
a bond
H
a bond
NH
S
a bond
T3b
OH


2213
CH
O
Q1c
a bond
H
a bond
NH
S
a bond
T3c
OH


2214
CH
O
Q1c
a bond
H
a bond
NH
S
a bond
T3d
OH


2215
CH
O
Q1c
a bond
H
a bond
NH
S
a bond
T3e
OH


2216
CH
O
Q1c
a bond
H
a bond
NH
S
a bond
T3f
OH


2217
CH
O
Q1c
a bond
H
a bond
NH
S
a bond
T3g
OH


2218
CH
O
Q1c
a bond
H
a bond
NH
S
a bond
T3h
OH


2219
CH
O
Q1c
a bond
H
a bond
NH
S
a bond
T3i
OH


2220
CH
O
Q1c
a bond
H
a bond
NH
S
a bond
T3j
OH


2221
CH
O
Q1c
a bond
H
a bond
NH
O
NH
T3a
OH


2222
CH
O
Q1c
a bond
H
a bond
NH
O
NH
T3b
OH


2223
CH
O
Q1c
a bond
H
a bond
NH
O
NH
T3c
OH


2224
CH
O
Q1c
a bond
H
a bond
NH
O
NH
T3d
OH


2225
CH
O
Q1c
a bond
H
a bond
NH
O
NH
T3e
OH


2226
CH
O
Q1c
a bond
H
a bond
NH
O
NH
T3f
OH


2227
CH
O
Q1c
a bond
H
a bond
NH
O
NH
T3g
OH


2228
CH
O
Q1c
a bond
H
a bond
NH
O
NH
T3h
OH


2229
CH
O
Q1c
a bond
H
a bond
NH
O
NH
T3i
OH


2230
CH
O
Q1c
a bond
H
a bond
NH
O
NH
T3j
OH


2231
CH
O
Q1c
a bond
H
a bond
NH
O
a bond
T3a
OH


2232
CH
O
Q1c
a bond
H
a bond
NH
O
a bond
T3b
OH


2233
CH
O
Q1c
a bond
H
a bond
NH
O
a bond
T3c
OH


2234
CH
O
Q1c
a bond
H
a bond
NH
O
a bond
T3d
OH


2235
CH
O
Q1c
a bond
H
a bond
NH
O
a bond
T3e
OH


2236
CH
O
Q1c
a bond
H
a bond
NH
O
a bond
T3f
OH


2237
CH
O
Q1c
a bond
H
a bond
NH
O
a bond
T3g
OH


2238
CH
O
Q1c
a bond
H
a bond
NH
O
a bond
T3h
OH


2239
CH
O
Q1c
a bond
H
a bond
NH
O
a bond
T3i
OH


2240
CH
O
Q1c
a bond
H
a bond
NH
O
a bond
T3j
OH


2241
CH
O
Q1i
a bond
Me
a bond
NH
S
NH
T3a
OH


2242
CH
O
Q1i
a bond
Me
a bond
NH
S
NH
T3b
OH


2243
CH
O
Q1i
a bond
Me
a bond
NH
S
NH
T3c
OH


2244
CH
O
Q1i
a bond
Me
a bond
NH
S
NH
T3d
OH


2245
CH
O
Q1i
a bond
Me
a bond
NH
S
NH
T3e
OH


2246
CH
O
Q1i
a bond
Me
a bond
NH
S
NH
T3f
OH


2247
CH
O
Q1i
a bond
Me
a bond
NH
S
NH
T3g
OH


2248
CH
O
Q1i
a bond
Me
a bond
NH
S
NH
T3h
OH


2249
CH
O
Q1i
a bond
Me
a bond
NH
S
NH
T3i
OH


2250
CH
O
Q1i
a bond
Me
a bond
NH
S
NH
T3j
OH


2251
CH
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3a
OH


2252
CH
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3b
OH


2253
CH
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3c
OH


2254
CH
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3d
OH


2255
CH
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3e
OH


2256
CH
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3f
OH


2257
CH
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3g
OH


2258
CH
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3h
OH


2259
CH
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3i
OH


2260
CH
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3j
OH


2261
CH
O
Q1i
a bond
Me
a bond
NH
O
NH
T3a
OH


2262
CH
O
Q1i
a bond
Me
a bond
NH
O
NH
T3b
OH


2263
CH
O
Q1i
a bond
Me
a bond
NH
O
NH
T3c
OH


2264
CH
O
Q1i
a bond
Me
a bond
NH
O
NH
T3d
OH


2265
CH
O
Q1i
a bond
Me
a bond
NH
O
NH
T3e
OH


2266
CH
O
Q1i
a bond
Me
a bond
NH
O
NH
T3f
OH


2267
CH
O
Q1i
a bond
Me
a bond
NH
O
NH
T3g
OH


2268
CH
O
Q1i
a bond
Me
a bond
NH
O
NH
T3h
OH


2269
CH
O
Q1i
a bond
Me
a bond
NH
O
NH
T3i
OH


2270
CH
O
Q1i
a bond
Me
a bond
NH
O
NH
T3j
OH


2271
CH
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3a
OH


2272
CH
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3b
OH


2273
CH
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3c
OH


2274
CH
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3d
OH


2275
CH
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3e
OH


2276
CH
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3f
OH


2277
CH
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3g
OH


2278
CH
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3h
OH


2279
CH
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3i
OH


2280
CH
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3j
OH


2281
CH
O
Q1i
a bond
H
a bond
NH
S
NH
T3a
OH


2282
CH
O
Q1i
a bond
H
a bond
NH
S
NH
T3b
OH


2283
CH
O
Q1i
a bond
H
a bond
NH
S
NH
T3c
OH


2284
CH
O
Q1i
a bond
H
a bond
NH
S
NH
T3d
OH


2285
CH
O
Q1i
a bond
H
a bond
NH
S
NH
T3e
OH


2286
CH
O
Q1i
a bond
H
a bond
NH
S
NH
T3f
OH


2287
CH
O
Q1i
a bond
H
a bond
NH
S
NH
T3g
OH


2288
CH
O
Q1i
a bond
H
a bond
NH
S
NH
T3h
OH


2289
CH
O
Q1i
a bond
H
a bond
NH
S
NH
T3i
OH


2290
CH
O
Q1i
a bond
H
a bond
NH
S
NH
T3j
OH


2291
CH
O
Q1i
a bond
H
a bond
NH
S
a bond
T3a
OH


2292
CH
O
Q1i
a bond
H
a bond
NH
S
a bond
T3b
OH


2293
CH
O
Q1i
a bond
H
a bond
NH
S
a bond
T3c
OH


2294
CH
O
Q1i
a bond
H
a bond
NH
S
a bond
T3d
OH


2295
CH
O
Q1i
a bond
H
a bond
NH
S
a bond
T3e
OH


2296
CH
O
Q1i
a bond
H
a bond
NH
S
a bond
T3f
OH


2297
CH
O
Q1i
a bond
H
a bond
NH
S
a bond
T3g
OH


2298
CH
O
Q1i
a bond
H
a bond
NH
S
a bond
T3h
OH


2299
CH
O
Q1i
a bond
H
a bond
NH
S
a bond
T3i
OH


2300
CH
O
Q1i
a bond
H
a bond
NH
S
a bond
T3j
OH


2301
CH
O
Q1i
a bond
H
a bond
NH
O
NH
T3a
OH


2302
CH
O
Q1i
a bond
H
a bond
NH
O
NH
T3b
OH


2303
CH
O
Q1i
a bond
H
a bond
NH
O
NH
T3c
OH


2304
CH
O
Q1i
a bond
H
a bond
NH
O
NH
T3d
OH


2305
CH
O
Q1i
a bond
H
a bond
NH
O
NH
T3e
OH


2306
CH
O
Q1i
a bond
H
a bond
NH
O
NH
T3f
OH


2307
CH
O
Q1i
a bond
H
a bond
NH
O
NH
T3g
OH


2308
CH
O
Q1i
a bond
H
a bond
NH
O
NH
T3h
OH


2309
CH
O
Q1i
a bond
H
a bond
NH
O
NH
T3i
OH


2310
CH
O
Q1i
a bond
H
a bond
NH
O
NH
T3j
OH


2311
CH
O
Q1i
a bond
H
a bond
NH
O
a bond
T3a
OH


2312
CH
O
Q1i
a bond
H
a bond
NH
O
a bond
T3b
OH


2313
CH
O
Q1i
a bond
H
a bond
NH
O
a bond
T3c
OH


2314
CH
O
Q1i
a bond
H
a bond
NH
O
a bond
T3d
OH


2315
CH
O
Q1i
a bond
H
a bond
NH
O
a bond
T3e
OH


2316
CH
O
Q1i
a bond
H
a bond
NH
O
a bond
T3f
OH


2317
CH
O
Q1i
a bond
H
a bond
NH
O
a bond
T3g
OH


2318
CH
O
Q1i
a bond
H
a bond
NH
O
a bond
T3h
OH


2319
CH
O
Q1i
a bond
H
a bond
NH
O
a bond
T3i
OH


2320
CH
O
Q1i
a bond
H
a bond
NH
O
a bond
T3j
OH


2321
CH
O
Q1j
a bond
Me
a bond
NH
S
NH
T3a
OH


2322
CH
O
Q1j
a bond
Me
a bond
NH
S
NH
T3b
OH


2323
CH
O
Q1j
a bond
Me
a bond
NH
S
NH
T3c
OH


2324
CH
O
Q1j
a bond
Me
a bond
NH
S
NH
T3d
OH


2325
CH
O
Q1j
a bond
Me
a bond
NH
S
NH
T3e
OH


2326
CH
O
Q1j
a bond
Me
a bond
NH
S
NH
T3f
OH


2327
CH
O
Q1j
a bond
Me
a bond
NH
S
NH
T3g
OH


2328
CH
O
Q1j
a bond
Me
a bond
NH
S
NH
T3h
OH


2329
CH
O
Q1j
a bond
Me
a bond
NH
S
NH
T3i
OH


2330
CH
O
Q1j
a bond
Me
a bond
NH
S
NH
T3j
OH


2331
CH
O
Q1j
a bond
Me
a bond
NH
S
a bond
T3a
OH


2332
CH
O
Q1j
a bond
Me
a bond
NH
S
a bond
T3b
OH


2333
CH
O
Q1j
a bond
Me
a bond
NH
S
a bond
T3c
OH


2334
CH
O
Q1j
a bond
Me
a bond
NH
S
a bond
T3d
OH


2335
CH
O
Q1j
a bond
Me
a bond
NH
S
a bond
T3e
OH


2336
CH
O
Q1j
a bond
Me
a bond
NH
S
a bond
T3f
OH


2337
CH
O
Q1j
a bond
Me
a bond
NH
S
a bond
T3g
OH


2338
CH
O
Q1j
a bond
Me
a bond
NH
S
a bond
T3h
OH


2339
CH
O
Q1j
a bond
Me
a bond
NH
S
a bond
T3i
OH


2340
CH
O
Q1j
a bond
Me
a bond
NH
S
a bond
T3j
OH


2341
CH
O
Q1j
a bond
Me
a bond
NH
O
NH
T3a
OH


2342
CH
O
Q1j
a bond
Me
a bond
NH
O
NH
T3b
OH


2343
CH
O
Q1j
a bond
Me
a bond
NH
O
NH
T3c
OH


2344
CH
O
Q1j
a bond
Me
a bond
NH
O
NH
T3d
OH


2345
CH
O
Q1j
a bond
Me
a bond
NH
O
NH
T3e
OH


2346
CH
O
Q1j
a bond
Me
a bond
NH
O
NH
T3f
OH


2347
CH
O
Q1j
a bond
Me
a bond
NH
O
NH
T3g
OH


2348
CH
O
Q1j
a bond
Me
a bond
NH
O
NH
T3h
OH


2349
CH
O
Q1j
a bond
Me
a bond
NH
O
NH
T3i
OH


2350
CH
O
Q1j
a bond
Me
a bond
NH
O
NH
T3j
OH


2351
CH
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3a
OH


2352
CH
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3b
OH


2353
CH
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3c
OH


2354
CH
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3d
OH


2355
CH
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3e
OH


2356
CH
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3f
OH


2357
CH
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3g
OH


2358
CH
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3h
OH


2359
CH
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3i
OH


2360
CH
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3j
OH


2361
CH
O
Q1j
a bond
H
a bond
NH
S
NH
T3a
OH


2362
CH
O
Q1j
a bond
H
a bond
NH
S
NH
T3b
OH


2363
CH
O
Q1j
a bond
H
a bond
NH
S
NH
T3c
OH


2364
CH
O
Q1j
a bond
H
a bond
NH
S
NH
T3d
OH


2365
CH
O
Q1j
a bond
H
a bond
NH
S
NH
T3e
OH


2366
CH
O
Q1j
a bond
H
a bond
NH
S
NH
T3f
OH


2367
CH
O
Q1j
a bond
H
a bond
NH
S
NH
T3g
OH


2368
CH
O
Q1j
a bond
H
a bond
NH
S
NH
T3h
OH


2369
CH
O
Q1j
a bond
H
a bond
NH
S
NH
T3i
OH


2370
CH
O
Q1j
a bond
H
a bond
NH
S
NH
T3j
OH


2371
CH
O
Q1j
a bond
H
a bond
NH
S
a bond
T3a
OH


2372
CH
O
Q1j
a bond
H
a bond
NH
S
a bond
T3b
OH


2373
CH
O
Q1j
a bond
H
a bond
NH
S
a bond
T3c
OH


2374
CH
O
Q1j
a bond
H
a bond
NH
S
a bond
T3d
OH


2375
CH
O
Q1j
a bond
H
a bond
NH
S
a bond
T3e
OH


2376
CH
O
Q1j
a bond
H
a bond
NH
S
a bond
T3f
OH


2377
CH
O
Q1j
a bond
H
a bond
NH
S
a bond
T3g
OH


2378
CH
O
Q1j
a bond
H
a bond
NH
S
a bond
T3h
OH


2379
CH
O
Q1j
a bond
H
a bond
NH
S
a bond
T3i
OH


2380
CH
O
Q1j
a bond
H
a bond
NH
S
a bond
T3j
OH


2381
CH
O
Q1j
a bond
H
a bond
NH
O
NH
T3a
OH


2382
CH
O
Q1j
a bond
H
a bond
NH
O
NH
T3b
OH


2383
CH
O
Q1j
a bond
H
a bond
NH
O
NH
T3c
OH


2384
CH
O
Q1j
a bond
H
a bond
NH
O
NH
T3d
OH


2385
CH
O
Q1j
a bond
H
a bond
NH
O
NH
T3e
OH


2386
CH
O
Q1i
a bond
H
a bond
NH
O
NH
T3f
OH


2387
CH
O
Q1i
a bond
H
a bond
NH
O
NH
T3g
OH


2388
CH
O
Q1j
a bond
H
a bond
NH
O
NH
T3h
OH


2389
CH
O
Q1j
a bond
H
a bond
NH
O
NH
T3i
OH


2390
CH
O
Q1j
a bond
H
a bond
NH
O
NH
T3j
OH


2391
CH
O
Q1j
a bond
H
a bond
NH
O
a bond
T3a
OH


2392
CH
O
Q1j
a bond
H
a bond
NH
O
a bond
T3b
OH


2393
CH
O
Q1j
a bond
H
a bond
NH
O
a bond
T3c
OH


2394
CH
O
Q1j
a bond
H
a bond
NH
O
a bond
T3d
OH


2395
CH
O
Q1j
a bond
H
a bond
NH
O
a bond
T3e
OH


2396
CH
O
Q1j
a bond
H
a bond
NH
O
a bond
T3f
OH


2397
CH
O
Q1j
a bond
H
a bond
NH
O
a bond
T3g
OH


2398
CH
O
Q1j
a bond
H
a bond
NH
O
a bond
T3h
OH


2399
CH
O
Q1j
a bond
H
a bond
NH
O
a bond
T3i
OH


2400
CH
O
Q1j
a bond
H
a bond
NH
O
a bond
T3j
OH


2401
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3a
OH


2402
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3b
OH


2403
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3c
OH


2404
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3d
OH


2405
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3e
OH


2406
CMe
NNe
Q1a
a bond
Me
a bond
NH
S
NH
T3f
OH


2407
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3g
OH


2408
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3h
OH


2409
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3i
OH


2410
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
NH
T3j
OH


2411
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3a
OH


2412
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3b
OH


2413
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3c
OH


2414
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3d
OH


2415
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3e
OH


2416
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3f
OH


2417
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3g
OH


2418
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3h
OH


2419
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3i
OH


2420
CMe
NMe
Q1a
a bond
Me
a bond
NH
S
a bond
T3j
OH


2421
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3a
OH


2422
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3b
OH


2423
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3c
OH


2424
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3d
OH


2425
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3e
OH


2426
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3f
OH


2427
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3g
OH


2428
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3h
OH


2429
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3i
OH


2430
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
NH
T3j
OH


2431
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3a
OH


2432
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3b
OH


2433
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3c
OH


2434
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3d
OH


2435
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3e
OH


2436
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3f
OH


2437
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3g
OH


2438
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3h
OH


2439
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3i
OH


2440
CMe
NMe
Q1a
a bond
Me
a bond
NH
O
a bond
T3j
OH


2441
CMe
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3a
OH


2442
CMe
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3b
OH


2443
CMe
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3c
OH


2444
CMe
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3d
OH


2445
CMe
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3e
OH


2446
CMe
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3f
OH


2447
CMe
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3g
OH


2448
CMe
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3h
OH


2449
CMe
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3i
OH


2450
CMe
NMe
Q1a
a bond
H
a bond
NH
S
NH
T3j
OH


2451
CMe
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3a
OH


2452
CMe
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3b
OH


2453
CMe
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3c
OH


2454
CMe
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3d
OH


2455
CMe
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3e
OH


2456
CMe
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3f
OH


2457
CMe
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3g
OH


2458
CMe
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3h
OH


2459
CMe
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3i
OH


2460
CMe
NMe
Q1a
a bond
H
a bond
NH
S
a bond
T3j
OH


2461
CMe
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3a
OH


2462
CMe
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3b
OH


2463
CMe
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3c
OH


2464
CMe
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3d
OH


2465
CMe
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3e
OH


2466
CMe
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3f
OH


2467
CMe
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3g
OH


2468
CMe
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3h
OH


2469
CMe
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3i
OH


2470
CMe
NMe
Q1a
a bond
H
a bond
NH
O
NH
T3j
OH


2471
CMe
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3a
OH


2472
CMe
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3b
OH


2473
CMe
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3c
OH


2474
CMe
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3d
OH


2475
CMe
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3e
OH


2476
CMe
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3f
OH


2477
CMe
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3g
OH


2478
CMe
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3h
OH


2479
CMe
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3i
OH


2480
CMe
NMe
Q1a
a bond
H
a bond
NH
O
a bond
T3j
OH


2481
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3a
OH


2482
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3b
OH


2483
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3c
OH


2484
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3d
OH


2485
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3e
OH


2486
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3f
OH


2487
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3g
OH


2488
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3h
OH


2489
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3i
OH


2490
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
NH
T3j
OH


2491
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3a
OH


2492
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3b
OH


2493
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3c
OH


2494
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3d
OH


2495
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3e
OH


2496
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3f
OH


2497
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3g
OH


2498
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3h
OH


2499
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3i
OH


2500
CMe
NMe
Q1b
a bond
Me
a bond
NH
S
a bond
T3j
OH


2501
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3a
OH


2502
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3b
OH


2503
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3c
OH


2504
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3d
OH


2505
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3e
OH


2506
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3f
OH


2507
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3g
OH


2508
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3h
OH


2509
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3i
OH


2510
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
NH
T3j
OH


2511
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3a
OH


2512
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3b
OH


2513
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3c
OH


2514
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3d
OH


2515
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3e
OH


2516
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3f
OH


2517
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3g
OH


2518
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3h
OH


2519
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3i
OH


2520
CMe
NMe
Q1b
a bond
Me
a bond
NH
O
a bond
T3j
OH


2521
CMe
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3a
OH


2522
CMe
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3b
OH


2523
CMe
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3c
OH


2524
CMe
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3d
OH


2525
CMe
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3e
OH


2526
CMe
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3f
OH


2527
CMe
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3g
OH


2528
CMe
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3h
OH


2529
CMe
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3i
OH


2530
CMe
NMe
Q1b
a bond
H
a bond
NH
S
NH
T3j
OH


2531
CMe
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3a
OH


2532
CMe
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3b
OH


2533
CMe
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3c
OH


2534
CMe
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3d
OH


2535
CMe
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3e
OH


2536
CMe
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3f
OH


2537
CMe
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3g
OH


2538
CMe
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3h
OH


2539
CMe
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3i
OH


2540
CMe
NMe
Q1b
a bond
H
a bond
NH
S
a bond
T3j
OH


2541
CMe
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3a
OH


2542
CMe
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3b
OH


2543
CMe
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3c
OH


2544
CMe
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3d
OH


2545
CMe
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3e
OH


2546
CMe
NNe
Q1b
a bond
H
a bond
NH
O
NH
T3f
OH


2547
CMe
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3g
OH


2548
CMe
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3h
OH


2549
CMe
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3i
OH


2550
CMe
NMe
Q1b
a bond
H
a bond
NH
O
NH
T3j
OH


2551
CMe
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3a
OH


2552
CMe
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3b
OH


2553
CMe
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3c
OH


2554
CMe
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3d
OH


2555
CMe
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3e
OH


2556
CMe
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3f
OH


2557
CMe
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3g
OH


2558
CMe
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3h
OH


2559
CMe
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T3i
OH


2560
CMe
NMe
Q1b
a bond
H
a bond
NH
O
a bond
T31
OH


2561
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3a
OH


2562
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3b
OH


2563
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3c
OH


2564
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3d
OH


2565
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3e
OH


2566
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3f
OH


2567
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3g
OH


2568
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3h
OH


2569
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3i
OH


2570
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
NH
T3j
OH


2571
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3a
OH


2572
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3b
OH


2573
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3c
OH


2574
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3d
OH


2575
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3e
OH


2576
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3f
OH


2577
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3g
OH


2578
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3h
OH


2579
CMe
NMe
Q1c
a bond
Me
a bond
NH
S
a bond
T3i
OH


2580
CMe
NNe
Q1c
a bond
Me
a bond
NH
S
a bond
T3j
OH


2581
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3a
OH


2582
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3b
OH


2583
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3c
OH


2584
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3d
OH


2585
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3e
OH


2586
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3f
OH


2587
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3g
OH


2588
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3h
OH


2589
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3i
OH


2590
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
NH
T3j
OH


2591
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3a
OH


2592
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3b
OH


2593
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3c
OH


2594
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3d
OH


2595
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3e
OH


2596
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3f
OH


2597
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3g
OH


2598
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3h
OH


2599
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3i
OH


2600
CMe
NMe
Q1c
a bond
Me
a bond
NH
O
a bond
T3j
OH


2601
CMe
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3a
OH


2602
CMe
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3b
OH


2603
CMe
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3c
OH


2604
CMe
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3d
OH


2605
CMe
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3e
OH


2606
CMe
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3f
OH


2607
CMe
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3g
OH


2608
CMe
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3h
OH


2609
CMe
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3i
OH


2610
CMe
NMe
Q1c
a bond
H
a bond
NH
S
NH
T3j
OH


2611
CMe
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3a
OH


2612
CMe
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3b
OH


2613
CMe
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3c
OH


2614
CMe
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3d
OH


2615
CMe
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3e
OH


2616
CMe
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3f
OH


2617
CMe
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3g
OH


2618
CMe
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3h
OH


2619
CMe
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3i
OH


2620
CMe
NMe
Q1c
a bond
H
a bond
NH
S
a bond
T3j
OH


2621
CMe
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3a
OH


2622
CMe
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3b
OH


2623
CMe
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3c
OH


2624
CMe
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3d
OH


2625
CMe
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3e
OH


2626
CMe
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3f
OH


2627
CMe
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3g
OH


2628
CMe
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3h
OH


2629
CMe
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3i
OH


2630
CMe
NMe
Q1c
a bond
H
a bond
NH
O
NH
T3j
OH


2631
CMe
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3a
OH


2632
CMe
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3b
OH


2633
CMe
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3c
OH


2634
CMe
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3d
OH


2635
CMe
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3e
OH


2636
CMe
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3f
OH


2637
CMe
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3g
OH


2638
CMe
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3h
OH


2639
CMe
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3i
OH


2640
CMe
NMe
Q1c
a bond
H
a bond
NH
O
a bond
T3j
OH


2641
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3a
OH


2642
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3b
OH


2643
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3c
OH


2644
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3d
OH


2645
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3e
OH


2646
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3f
OH


2647
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3g
OH


2648
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3h
OH


2649
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3i
OH


2650
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3j
OH


2651
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3a
OH


2652
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3b
OH


2653
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3c
OH


2654
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3d
OH


2655
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3e
OH


2656
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3f
OH


2657
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3g
OH


2658
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3h
OH


2659
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
T3i
OH


2660
CMe
NNe
Q1i
a bond
Me
a bond
NH
S
a bond
T3j
OH


2661
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3a
OH


2662
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3b
OH


2663
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3c
OH


2664
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3d
OH


2665
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3e
OH


2666
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3f
OH


2667
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3g
OH


2668
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3h
OH


2669
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3i
OH


2670
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3j
OH


2671
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3a
OH


2672
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3b
OH


2673
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3c
OH


2674
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3d
OH


2675
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3e
OH


2676
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3f
OH


2677
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3g
OH


2678
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3h
OH


2679
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3i
OH


2680
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
T3j
OH


2681
CMe
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3a
OH


2682
CMe
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3b
OH


2683
CMe
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3c
OH


2684
CMe
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3d
OH


2685
CMe
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3e
OH


2686
CMe
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3f
OH


2687
CMe
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3g
OH


2688
CMe
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3h
OH


2689
CMe
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3i
OH


2690
CMe
NMe
Q1i
a bond
H
a bond
NH
S
NH
T3j
OH


2691
CMe
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3a
OH


2692
CMe
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3b
OH


2693
CMe
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3c
OH


2694
CMe
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3d
OH


2695
CMe
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3e
OH


2696
CMe
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3f
OH


2697
CMe
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3g
OH


2698
CMe
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3h
OH


2699
CMe
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3i
OH


2700
CMe
NMe
Q1i
a bond
H
a bond
NH
S
a bond
T3j
OH


2701
CMe
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3a
OH


2702
CMe
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3b
OH


2703
CMe
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3c
OH


2704
CMe
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3d
OH


2705
CMe
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3e
OH


2706
CMe
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3f
OH


2707
CMe
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3g
OH


2708
CMe
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3h
OH


2709
CMe
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3i
OH


2710
CMe
NMe
Q1i
a bond
H
a bond
NH
O
NH
T3j
OH


2711
CMe
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3a
OH


2712
CMe
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3b
OH


2713
CMe
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3c
OH


2714
CMe
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3d
OH


2715
CMe
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3e
OH


2716
CMe
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3f
OH


2717
CMe
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3g
OH


2718
CMe
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3h
OH


2719
CMe
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3i
OH


2720
CMe
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3j
OH


2721
CMe
NMe
Q1j
a bond
Me
a bond
NH
S
NH
T3a
OH


2722
CMe
NMe
Q1j
a bond
Me
a bond
NH
S
NH
T3b
OH


2723
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3c
OH


2724
CMe
NMe
Q1j
a bond
Me
a bond
NH
S
NH
T3d
OH


2725
CMe
NMe
Q1j
a bond
Me
a bond
NH
S
NH
T3e
OH


2726
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3f
OH


2727
CMe
NMe
Q1j
a bond
Me
a bond
NH
S
NH
T3g
OH


2728
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3h
OH


2729
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
NH
T3i
OH


2730
CMe
NMe
Q1j
a bond
Me
a bond
NH
S
NH
T3j
OH


2731
CMe
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3a
OH


2732
CMe
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3b
OH


2733
CMe
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3c
OH


2734
CMe
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3d
OH


2735
CMe
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3e
OH


2736
CMe
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3f
OH


2737
CMe
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3g
OH


2738
CMe
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3h
OH


2739
CMe
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3i
OH


2740
CMe
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
T3j
OH


2741
CMe
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3a
OH


2742
CMe
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3b
OH


2743
CMe
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3c
OH


2744
CMe
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3d
OH


2745
CMe
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3e
OH


2746
CMe
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3f
OH


2747
CMe
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3g
OH


2748
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
NH
T3h
OH


2749
CMe
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3i
OH


2750
CMe
NMe
Q1j
a bond
Me
a bond
NH
O
NH
T3j
OH


2751
CMe
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3a
OH


2752
CMe
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3b
OH


2753
CMe
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3c
OH


2754
CMe
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3d
OH


2755
CMe
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3e
OH


2756
CMe
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3f
OH


2757
CMe
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3g
OH


2758
CMe
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3h
OH


2759
CMe
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3i
OH


2760
CMe
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
T3j
OH


2761
CMe
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3a
OH


2762
CMe
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3b
OH


2763
CMe
NMe
Qij
a bond
H
a bond
NH
S
NH
T3c
OH


2764
CMe
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3d
OH


2765
CMe
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3e
OH


2766
CMe
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3f
OH


2767
CMe
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3g
OH


2768
CMe
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3h
OH


2769
CMe
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3i
OH


2770
CMe
NMe
Q1j
a bond
H
a bond
NH
S
NH
T3j
OH


2771
CMe
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3a
OH


2772
CMe
NNe
Q1j
a bond
H
a bond
NH
S
a bond
T3b
OH


2773
CMe
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3c
OH


2774
CMe
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3d
OH


2775
CMe
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3e
OH


2776
CMe
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3f
OH


2777
CMe
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3g
OH


2778
CMe
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3h
OH


2779
CMe
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3i
OH


2780
CMe
NMe
Q1j
a bond
H
a bond
NH
S
a bond
T3j
OH


2781
CMe
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3a
OH


2782
CMe
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3b
OH


2783
CMe
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3c
OH


2784
CMe
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3d
OH


2785
CMe
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3e
OH


2786
CMe
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3f
OH


2787
CMe
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3g
OH


2788
CMe
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3h
OH


2789
CMe
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3i
OH


2790
CMe
NMe
Q1j
a bond
H
a bond
NH
O
NH
T3j
OH


2791
CMe
NMe
Q1j
a bond
H
a bond
NH
O
a bond
T3a
OH


2792
CMe
NMe
Q1j
a bond
H
a bond
NH
O
a bond
T3b
OH


2793
CMe
NMe
Q1j
a bond
H
a bond
NH
O
a bond
T3c
OH


2794
CMe
NMe
Q1j
a bond
H
a bond
NH
O
a bond
T3d
OH


2795
CMe
NMe
Q1i
a bond
H
a bond
NH
O
a bond
T3e
OH


2796
CMe
NMe
Q1j
a bond
H
a bond
NH
O
a bond
T3f
OH


2797
CMe
NMe
Q1j
a bond
H
a bond
NH
O
a bond
T3g
OH


2798
CMe
NMe
Q1j
a bond
H
a bond
NH
O
a bond
T3h
OH


2799
CMe
NMe
Q1j
a bond
H
a bond
NH
O
a bond
T3i
OH


2800
CMe
NMe
Q1j
a bond
H
a bond
NH
O
a bond
T3j
OH


2801
CMe
S
Q1a
a bond
Me
a bond
NH
S
NH
T3a
OH


2802
CMe
S
Q1a
a bond
Me
a bond
NH
S
NH
T3b
OH


2803
CMe
S
Q1a
a bond
Me
a bond
NH
S
NH
T3c
OH


2804
CMe
S
Q1a
a bond
Me
a bond
NH
S
NH
T3d
OH


2805
CMe
S
Q1a
a bond
Me
a bond
NH
S
NH
T3e
OH


2806
CMe
S
Q1a
a bond
Me
a bond
NH
S
NH
T3f
OH


2807
CMe
S
Q1a
a bond
Me
a bond
NH
S
NH
T3g
OH


2808
CMe
S
Q1a
a bond
Me
a bond
NH
S
NH
T3h
OH


2809
CMe
S
Q1a
a bond
Me
a bond
NH
S
NH
T3i
OH


2810
CMe
S
Q1a
a bond
Me
a bond
NH
S
NH
T3j
OH


2811
CMe
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3a
OH


2812
CMe
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3b
OH


2813
CMe
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3c
OH


2814
CMe
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3d
OH


2815
CMe
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3e
OH


2816
CMe
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3f
OH


2817
CMe
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3g
OH


2818
CMe
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3h
OH


2819
CMe
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3i
OH


2820
CMe
S
Q1a
a bond
Me
a bond
NH
S
a bond
T3j
OH


2821
CMe
S
Q1a
a bond
Me
a bond
NH
O
NH
T3a
OH


2822
CMe
S
Q1a
a bond
Me
a bond
NH
O
NH
T3b
OH


2823
CMe
S
Q1a
a bond
Me
a bond
NH
O
NH
T3c
OH


2824
CMe
S
Q1a
a bond
Me
a bond
NH
O
NH
T3d
OH


2825
CMe
S
Q1a
a bond
Me
a bond
NH
O
NH
T3e
OH


2826
CMe
S
Q1a
a bond
Me
a bond
NH
O
NH
T3f
OH


2827
CMe
S
Q1a
a bond
Me
a bond
NH
O
NH
T3g
OH


2828
CMe
S
Q1a
a bond
Me
a bond
NH
O
NH
T3h
OH


2829
CMe
S
Q1a
a bond
Me
a bond
NH
O
NH
T3i
OH


2830
CMe
S
Q1a
a bond
Me
a bond
NH
O
NH
T3j
OH


2831
CMe
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3a
OH


2832
CMe
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3b
OH


2833
CMe
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3c
OH


2834
CMe
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3d
OH


2835
CMe
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3e
OH


2836
CMe
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3f
OH


2837
CMe
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3g
OH


2838
CMe
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3h
OH


2839
CMe
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3i
OH


2840
CMe
S
Q1a
a bond
Me
a bond
NH
O
a bond
T3j
OH


2841
CMe
S
Q1a
a bond
H
a bond
NH
S
NH
T3a
OH


2842
CMe
S
Q1a
a bond
H
a bond
NH
S
NH
T3b
OH


2843
CMe
S
Q1a
a bond
H
a bond
NH
S
NH
T3c
OH


2844
CMe
S
Q1a
a bond
H
a bond
NH
S
NH
T3d
OH


2845
CMe
S
Q1a
a bond
H
a bond
NH
S
NH
T3e
OH


2846
CMe
S
Q1a
a bond
H
a bond
NH
S
NH
T3f
OH


2847
CMe
S
Q1a
a bond
H
a bond
NH
S
NH
T3g
OH


2848
CMe
S
Q1a
a bond
H
a bond
NH
S
NH
T3h
OH


2849
CMe
S
Q1a
a bond
H
a bond
NH
S
NH
T3i
OH


2850
CMe
S
Q1a
a bond
H
a bond
NH
S
NH
T3j
OH


2851
CMe
S
Q1a
a bond
H
a bond
NH
S
a bond
T3a
OH


2852
CMe
S
Q1a
a bond
H
a bond
NH
S
a bond
T3b
OH


2853
CMe
S
Q1a
a bond
H
a bond
NH
S
a bond
T3c
OH


2854
CMe
S
Q1a
a bond
H
a bond
NH
S
a bond
T3d
OH


2855
CMe
S
Q1a
a bond
H
a bond
NH
S
a bond
T3e
OH


2856
CMe
S
Q1a
a bond
H
a bond
NH
S
a bond
T3f
OH


2857
CMe
S
Q1a
a bond
H
a bond
NH
S
a bond
T3g
OH


2858
CMe
S
Q1a
a bond
H
a bond
NH
S
a bond
T3h
OH


2859
CMe
S
Q1a
a bond
H
a bond
NH
S
a bond
T3i
OH


2860
CMe
S
Q1a
a bond
H
a bond
NH
S
a bond
T3j
OH


2861
CMe
S
Q1a
a bond
H
a bond
NH
O
NH
T3a
OH


2862
CMe
S
Q1a
a bond
H
a bond
NH
O
NH
T3b
OH


2863
CMe
S
Q1a
a bond
H
a bond
NH
O
NH
T3c
OH


2864
CMe
S
Q1a
a bond
H
a bond
NH
O
NH
T3d
OH


2865
CMe
S
Q1a
a bond
H
a bond
NH
O
NH
T3e
OH


2866
CMe
S
Q1a
a bond
H
a bond
NH
O
NH
T3f
OH


2867
CMe
S
Q1a
a bond
H
a bond
NH
O
NH
T3g
OH


2868
CMe
S
Q1a
a bond
H
a bond
NH
O
NH
T3h
OH


2869
CMe
S
Q1a
a bond
H
a bond
NH
O
NH
T3i
OH


2870
CMe
S
Q1a
a bond
H
a bond
NH
O
NH
T3j
OH


2871
CMe
S
Q1a
a bond
H
a bond
NH
O
a bond
T3a
OH


2872
CMe
S
Q1a
a bond
H
a bond
NH
O
a bond
T3b
OH


2873
CMe
S
Q1a
a bond
H
a bond
NH
O
a bond
T3c
OH


2874
CMe
S
Q1a
a bond
H
a bond
NH
O
a bond
T3d
OH


2875
CMe
S
Q1a
a bond
H
a bond
NH
O
a bond
T3e
OH


2876
CMe
S
Q1a
a bond
H
a bond
NH
O
a bond
T3f
OH


2877
CMe
S
Q1a
a bond
H
a bond
NH
O
a bond
T3g
OH


2878
CMe
S
Q1a
a bond
H
a bond
NH
O
a bond
T3h
OH


2879
CMe
S
Q1a
a bond
H
a bond
NH
O
a bond
T3i
OH


2880
CMe
S
Q1a
a bond
H
a bond
NH
O
a bond
T3j
OH


2881
CMe
S
Q1b
a bond
Me
a bond
NH
S
NH
T3a
OH


2882
CMe
S
Q1b
a bond
Me
a bond
NH
S
NH
T3b
OH


2883
CMe
S
Q1b
a bond
Me
a bond
NH
S
NH
T3c
OH


2884
CMe
S
Q1b
a bond
Me
a bond
NH
S
NH
T3d
OH


2885
CMe
S
Q1b
a bond
Me
a bond
NH
S
NH
T3e
OH


2886
CMe
S
Q1b
a bond
Me
a bond
NH
S
NH
T3f
OH


2887
CMe
S
Q1b
a bond
Me
a bond
NH
S
NH
T3g
OH


2888
CMe
S
Q1b
a bond
Me
a bond
NH
S
NH
T3h
OH


2889
CMe
S
Q1b
a bond
Me
a bond
NH
S
NH
T3i
OH


2890
CMe
S
Q1b
a bond
Me
a bond
NH
S
NH
T3j
OH


2891
CMe
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3a
OH


2892
CMe
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3b
OH


2893
CMe
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3c
OH


2894
CMe
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3d
OH


2895
CMe
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3e
OH


2896
CMe
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3f
OH


2897
CMe
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3g
OH


2898
CMe
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3h
OH


2899
CMe
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3i
OH


2900
CMe
S
Q1b
a bond
Me
a bond
NH
S
a bond
T3j
OH


2901
CMe
S
Q1b
a bond
Me
a bond
NH
O
NH
T3a
OH


2902
CMe
S
Q1b
a bond
Me
a bond
NH
O
NH
T3b
OH


2903
CMe
S
Q1b
a bond
Me
a bond
NH
O
NH
T3c
OH


2904
CMe
S
Q1b
a bond
Me
a bond
NH
O
NH
T3d
OH


2905
CMe
S
Q1b
a bond
Me
a bond
NH
O
NH
T3e
OH


2906
CMe
S
Q1b
a bond
Me
a bond
NH
O
NH
T3f
OH


2907
CMe
S
Q1b
a bond
Me
a bond
NH
O
NH
T3g
OH


2908
CMe
S
Q1b
a bond
Me
a bond
NH
O
NH
T3h
OH


2909
CMe
S
Q1b
a bond
Me
a bond
NH
O
NH
T3i
OH


2910
CMe
S
Q1b
a bond
Me
a bond
NH
O
NH
T3j
OH


2911
CMe
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3a
OH


2912
CMe
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3b
OH


2913
CMe
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3c
OH


2914
CMe
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3d
OH


2915
CMe
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3e
OH


2916
CMe
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3f
OH


2917
CMe
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3g
OH


2918
CMe
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3h
OH


2919
CMe
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3i
OH


2920
CMe
S
Q1b
a bond
Me
a bond
NH
O
a bond
T3j
OH


2921
CMe
S
Q1b
a bond
H
a bond
NH
S
NH
T3a
OH


2922
CMe
S
Q1b
a bond
H
a bond
NH
S
NH
T3b
OH


2923
CMe
S
Q1b
a bond
H
a bond
NH
S
NH
T3c
OH


2924
CMe
S
Q1b
a bond
H
a bond
NH
S
NH
T3d
OH


2925
CMe
S
Q1b
a bond
H
a bond
NH
S
NH
T3e
OH


2926
CMe
S
Q1b
a bond
H
a bond
NH
S
NH
T3f
OH


2927
CMe
S
Q1b
a bond
H
a bond
NH
S
NH
T3g
OH


2928
CMe
S
Q1b
a bond
H
a bond
NH
S
NH
T3h
OH


2929
CMe
S
Q1b
a bond
H
a bond
NH
S
NH
T3i
OH


2930
CMe
S
Q1b
a bond
H
a bond
NH
S
NH
T3j
OH


2931
CMe
S
Q1b
a bond
H
a bond
NH
S
a bond
T3a
OH


2932
CMe
S
Q1b
a bond
H
a bond
NH
S
a bond
T3b
OH


2933
CMe
S
Q1b
a bond
H
a bond
NH
S
a bond
T3c
OH


2934
CMe
S
Q1b
a bond
H
a bond
NH
S
a bond
T3d
OH


2935
CMe
S
Q1b
a bond
H
a bond
NH
S
a bond
T3e
OH


2936
CMe
S
Q1b
a bond
H
a bond
NH
S
a bond
T3f
OH


2937
CMe
S
Q1b
a bond
H
a bond
NH
S
a bond
T3g
OH


2938
CMe
S
Q1b
a bond
H
a bond
NH
S
a bond
T3h
OH


2939
CMe
S
Q1b
a bond
H
a bond
NH
S
a bond
T3i
OH


2940
CMe
S
Q1b
a bond
H
a bond
NH
S
a bond
T3j
OH


2941
CMe
S
Q1b
a bond
H
a bond
NH
O
NH
T3a
OH


2942
CMe
S
Q1b
a bond
H
a bond
NH
O
NH
T3b
OH


2943
CMe
S
Q1b
a bond
H
a bond
NH
O
NH
T3c
OH


2944
CMe
S
Q1b
a bond
H
a bond
NH
O
NH
T3d
OH


2945
CMe
S
Q1b
a bond
H
a bond
NH
O
NH
T3e
OH


2946
CMe
S
Q1b
a bond
H
a bond
NH
O
NH
T3f
OH


2947
CMe
S
Q1b
a bond
H
a bond
NH
O
NH
T3g
OH


2948
CMe
S
Q1b
a bond
H
a bond
NH
O
NH
T3h
OH


2949
CMe
S
Q1b
a bond
H
a bond
NH
O
NH
T3i
OH


2950
CMe
S
Q1b
a bond
H
a bond
NH
O
NH
T3j
OH


2951
CMe
S
Q1b
a bond
H
a bond
NH
O
a bond
T3a
OH


2952
CMe
S
Q1b
a bond
H
a bond
NH
O
a bond
T3b
OH


2953
CMe
S
Q1b
a bond
H
a bond
NH
O
a bond
T3c
OH


2954
CMe
S
Q1b
a bond
H
a bond
NH
O
a bond
T3d
OH


2955
CMe
S
Q1b
a bond
H
a bond
NH
O
a bond
T3e
OH


2956
CMe
S
Q1b
a bond
H
a bond
NH
O
a bond
T3f
OH


2957
CMe
S
Q1b
a bond
H
a bond
NH
O
a bond
T3g
OH


2958
CMe
S
Q1b
a bond
H
a bond
NH
O
a bond
T3h
OH


2959
CMe
S
Q1b
a bond
H
a bond
NH
O
a bond
T3i
OH


2960
CMe
S
Q1b
a bond
H
a bond
NH
O
a bond
T3j
OH


2961
CMe
S
Q1c
a bond
Me
a bond
NH
S
NH
T3a
OH


2962
CMe
S
Q1c
a bond
Me
a bond
NH
S
NH
T3b
OH


2963
CMe
S
Q1c
a bond
Me
a bond
NH
S
NH
T3c
OH


2964
CMe
S
Q1c
a bond
Me
a bond
NH
S
NH
T3d
OH


2965
CMe
S
Q1c
a bond
Me
a bond
NH
S
NH
T3e
OH


2966
CMe
S
Q1c
a bond
Me
a bond
NH
S
NH
T3f
OH


2967
CMe
S
Q1c
a bond
Me
a bond
NH
S
NH
T3g
OH


2968
CMe
S
Q1c
a bond
Me
a bond
NH
S
NH
T3h
OH


2969
CMe
S
Q1c
a bond
Me
a bond
NH
S
NH
T3i
OH


2970
CMe
S
Q1c
a bond
Me
a bond
NH
S
NH
T3j
OH


2971
CMe
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3a
OH


2972
CMe
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3b
OH


2973
CMe
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3c
OH


2974
CMe
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3d
OH


2975
CMe
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3e
OH


2976
CMe
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3f
OH


2977
CMe
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3g
OH


2978
CMe
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3h
OH


2979
CMe
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3i
OH


2980
CMe
S
Q1c
a bond
Me
a bond
NH
S
a bond
T3j
OH


2981
CMe
S
Q1c
a bond
Me
a bond
NH
O
NH
T3a
OH


2982
CMe
S
Q1c
a bond
Me
a bond
NH
O
NH
T3b
OH


2983
CMe
S
Q1c
a bond
Me
a bond
NH
O
NH
T3c
OH


2984
CMe
S
Q1c
a bond
Me
a bond
NH
O
NH
T3d
OH


2985
CMe
S
Q1c
a bond
Me
a bond
NH
O
NH
T3e
OH


2986
CMe
S
Q1c
a bond
Me
a bond
NH
O
NH
T3f
OH


2987
CMe
S
Q1c
a bond
Me
a bond
NH
O
NH
T3g
OH


2988
CMe
S
Q1c
a bond
Me
a bond
NH
O
NH
T3h
OH


2989
CMe
S
Q1c
a bond
Me
a bond
NH
O
NH
T3i
OH


2990
CMe
S
Q1c
a bond
Me
a bond
NH
O
NH
T3j
OH


2991
CMe
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3a
OH


2992
CMe
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3b
OH


2993
CMe
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3c
OH


2994
CMe
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3d
OH


2995
CMe
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3e
OH


2996
CMe
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3f
OH


2997
CMe
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3g
OH


2998
CMe
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3h
OH


2999
CMe
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3i
OH


3000
CMe
S
Q1c
a bond
Me
a bond
NH
O
a bond
T3j
OH


3001
CMe
S
Q1c
a bond
H
a bond
NH
S
NH
T3a
OH


3002
CMe
S
Q1c
a bond
H
a bond
NH
S
NH
T3b
OH


3003
CMe
S
Q1c
a bond
H
a bond
NH
S
NH
T3c
OH


3004
CMe
S
Q1c
a bond
H
a bond
NH
S
NH
T3d
OH


3005
CMe
S
Q1c
a bond
H
a bond
NH
S
NH
T3e
OH


3006
CMe
S
Q1c
a bond
H
a bond
NH
S
NH
T3f
OH


3007
CMe
S
Q1c
a bond
H
a bond
NH
S
NH
T3g
OH


3008
CMe
S
Q1c
a bond
H
a bond
NH
S
NH
T3h
OH


3009
CMe
S
Q1c
a bond
H
a bond
NH
S
NH
T3i
OH


3010
CMe
S
Q1c
a bond
H
a bond
NH
S
NH
T3j
OH


3011
CMe
S
Q1c
a bond
H
a bond
NH
S
a bond
T3a
OH


3012
CMe
S
Q1c
a bond
H
a bond
NH
S
a bond
T3b
OH


3013
CMe
S
Q1c
a bond
H
a bond
NH
S
a bond
T3c
OH


3014
CMe
S
Q1c
a bond
H
a bond
NH
S
a bond
T3d
OH


3015
CMe
S
Q1c
a bond
H
a bond
NH
S
a bond
T3e
OH


3016
CMe
S
Q1c
a bond
H
a bond
NH
S
a bond
T3f
OH


3017
CMe
S
Q1c
a bond
H
a bond
NH
S
a bond
T3g
OH


3018
CMe
S
Q1c
a bond
H
a bond
NH
S
a bond
T3h
OH


3019
CMe
S
Q1c
a bond
H
a bond
NH
S
a bond
T3i
OH


3020
CMe
S
Q1c
a bond
H
a bond
NH
S
a bond
T3j
OH


3021
CMe
S
Q1c
a bond
H
a bond
NH
O
NH
T3a
OH


3022
CMe
S
Q1c
a bond
H
a bond
NH
O
NH
T3b
OH


3023
CMe
S
Q1c
a bond
H
a bond
NH
O
NH
T3c
OH


3024
CMe
S
Q1c
a bond
H
a bond
NH
O
NH
T3d
OH


3025
CMe
S
Q1c
a bond
H
a bond
NH
O
NH
T3e
OH


3026
CMe
S
Q1c
a bond
H
a bond
NH
O
NH
T3f
OH


3027
CMe
S
Q1c
a bond
H
a bond
NH
O
NH
T3g
OH


3028
CMe
S
Q1c
a bond
H
a bond
NH
O
NH
T3h
OH


3029
CMe
S
Q1c
a bond
H
a bond
NH
O
NH
T3i
OH


3030
CMe
S
Q1c
a bond
H
a bond
NH
O
NH
T3j
OH


3031
CMe
S
Q1c
a bond
H
a bond
NH
O
a bond
T3a
OH


3032
CMe
S
Q1c
a bond
H
a bond
NH
O
a bond
T3b
OH


3033
CMe
S
Q1c
a bond
H
a bond
NH
O
a bond
T3c
OH


3034
CMe
S
Q1c
a bond
H
a bond
NH
O
a bond
T3d
OH


3035
CMe
S
Q1c
a bond
H
a bond
NH
O
a bond
T3e
OH


3036
CMe
S
Q1c
a bond
H
a bond
NH
O
a bond
T3f
OH


3037
CMe
S
Q1c
a bond
H
a bond
NH
O
a bond
T3g
OH


3038
CMe
S
Q1c
a bond
H
a bond
NH
O
a bond
T3h
OH


3039
CMe
S
Q1c
a bond
H
a bond
NH
O
a bond
T3i
OH


3040
CMe
S
Q1c
a bond
H
a bond
NH
O
a bond
T3j
OH


3041
CMe
S
Q1i
a bond
Me
a bond
NH
S
NH
T3a
OH


3042
CMe
S
Q1i
a bond
Me
a bond
NH
S
NH
T3b
OH


3043
CMe
S
Q1i
a bond
Me
a bond
NH
S
NH
T3c
OH


3044
CMe
S
Q1i
a bond
Me
a bond
NH
S
NH
T3d
OH


3045
CMe
S
Q1i
a bond
Me
a bond
NH
S
NH
T3e
OH


3046
CMe
S
Q1i
a bond
Me
a bond
NH
S
NH
T3f
OH


3047
CMe
S
Q1i
a bond
Me
a bond
NH
S
NH
T3g
OH


3048
CMe
S
Q1i
a bond
Me
a bond
NH
S
NH
T3h
OH


3049
CMe
S
Q1i
a bond
Me
a bond
NH
S
NH
T3i
OH


3050
CMe
S
Q1i
a bond
Me
a bond
NH
S
NH
T3j
OH


3051
CMe
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3a
OH


3052
CMe
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3b
OH


3053
CMe
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3c
OH


3054
CMe
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3d
OH


3055
CMe
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3e
OH


3056
CMe
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3f
OH


3057
CMe
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3g
OH


3058
CMe
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3h
OH


3059
CMe
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3i
OH


3060
CMe
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3j
OH


3061
CMe
S
Q1i
a bond
Me
a bond
NH
O
NH
T3a
OH


3062
CMe
S
Q1i
a bond
Me
a bond
NH
O
NH
T3b
OH


3063
CMe
S
Q1i
a bond
Me
a bond
NH
O
NH
T3c
OH


3064
CMe
S
Q1i
a bond
Me
a bond
NH
O
NH
T3d
OH


3065
CMe
S
Q1i
a bond
Me
a bond
NH
O
NH
T3e
OH


3066
CMe
S
Q1i
a bond
Me
a bond
NH
O
NH
T3f
OH


3067
CMe
S
Q1i
a bond
Me
a bond
NH
O
NH
T3g
OH


3068
CMe
S
Q1i
a bond
Me
a bond
NH
O
NH
T3h
OH


3069
CMe
S
Q1i
a bond
Me
a bond
NH
O
NH
T3i
OH


3070
CMe
S
Q1i
a bond
Me
a bond
NH
O
NH
T3j
OH


3071
CMe
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3a
OH


3072
CMe
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3b
OH


3073
CMe
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3c
OH


3074
CMe
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3d
OH


3075
CMe
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3e
OH


3076
CMe
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3f
OH


3077
CMe
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3g
OH


3078
CMe
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3h
OH


3079
CMe
S
Q1i
a bond
Me
a bond
NH
O
a bond
T3i
OH


3080
CMe
S
Q1i
a bond
Me
a bond
NH
O
a bond
T31
OH


3081
CMe
S
Q1i
a bond
H
a bond
NH
S
NH
T3a
OH


3082
CMe
S
Q1i
a bond
H
a bond
NH
S
NH
T3b
OH


3083
CMe
S
Q1i
a bond
H
a bond
NH
S
NH
T3c
OH


3084
CMe
S
Q1i
a bond
H
a bond
NH
S
NH
T3d
OH


3085
CMe
S
Q1i
a bond
H
a bond
NH
S
NH
T3e
OH


3086
CMe
S
Q1i
a bond
H
a bond
NH
S
NH
T3f
OH


3087
CMe
S
Q1i
a bond
H
a bond
NH
S
NH
T3g
OH


3088
CMe
S
Q1i
a bond
H
a bond
NH
S
NH
T3h
OH


3089
CMe
S
Q1i
a bond
H
a bond
NH
S
NH
T3i
OH


3090
CMe
S
Q1i
a bond
H
a bond
NH
S
NH
T3j
OH


3091
CMe
S
Q1i
a bond
H
a bond
NH
S
a bond
T3a
OH


3092
CMe
S
Q1i
a bond
H
a bond
NH
S
a bond
T3b
OH


3093
CMe
S
Q1i
a bond
H
a bond
NH
S
a bond
T3c
OH


3094
CMe
S
Q1i
a bond
H
a bond
NH
S
a bond
T3d
OH


3095
CMe
S
Q1i
a bond
H
a bond
NH
S
a bond
T3e
OH


3096
CMe
S
Q1i
a bond
H
a bond
NH
S
a bond
T3f
OH


3097
CMe
S
Q1i
a bond
H
a bond
NH
S
a bond
T3g
OH


3098
CMe
S
Q1i
a bond
H
a bond
NH
S
a bond
T3h
OH


3099
CMe
S
Q1i
a bond
H
a bond
NH
S
a bond
T3i
OH


3100
CMe
S
Q1i
a bond
H
a bond
NH
S
a bond
T3j
OH


3101
CMe
S
Q1i
a bond
H
a bond
NH
O
NH
T3a
OH


3102
CMe
S
Q1i
a bond
H
a bond
NH
O
NH
T3b
OH


3103
CMe
S
Q1i
a bond
H
a bond
NH
O
NH
T3c
OH


3104
CMe
S
Q1i
a bond
H
a bond
NH
O
NH
T3d
OH


3105
CMe
S
Q1i
a bond
H
a bond
NH
O
NH
T3e
OH


3106
CMe
S
Q1i
a bond
H
a bond
NH
O
NH
T3f
OH


3107
CMe
S
Q1i
a bond
H
a bond
NH
O
NH
T3g
OH


3108
CMe
S
Q1i
a bond
H
a bond
NH
O
NH
T3h
OH


3109
CMe
S
Q1i
a bond
H
a bond
NH
O
NH
T3i
OH


3110
CMe
S
Q1i
a bond
H
a bond
NH
O
NH
T3j
OH


3111
CMe
S
Q1i
a bond
H
a bond
NH
O
a bond
T3a
OH


3112
CMe
S
Q1i
a bond
H
a bond
NH
O
a bond
T3b
OH


3113
CMe
S
Q1i
a bond
H
a bond
NH
O
a bond
T3c
OH


3114
CMe
S
Q1i
a bond
H
a bond
NH
O
a bond
T3d
OH


3115
CMe
S
Q1i
a bond
H
a bond
NH
O
a bond
T3e
OH


3116
CMe
S
Q1i
a bond
H
a bond
NH
O
a bond
T3f
OH


3117
CMe
S
Q1i
a bond
H
a bond
NH
O
a bond
T3g
OH


3118
CMe
S
Q1i
a bond
H
a bond
NH
O
a bond
T3h
OH


3119
CMe
S
Q1i
a bond
H
a bond
NH
O
a bond
T3i
OH


3120
CMe
S
Q1i
a bond
H
a bond
NH
O
a bond
T3j
OH


3121
CMe
S
Q1j
a bond
Me
a bond
NH
S
NH
T3a
OH


3122
CMe
S
Q1j
a bond
Me
a bond
NH
S
NH
T3b
OH


3123
CMe
S
Q1j
a bond
Me
a bond
NH
S
NH
T3c
OH


3124
CMe
S
Q1j
a bond
Me
a bond
NH
S
NH
T3d
OH


3125
CMe
S
Q1j
a bond
Me
a bond
NH
S
NH
T3e
OH


3126
CMe
S
Q1j
a bond
Me
a bond
NH
S
NH
T3f
OH


3127
CMe
S
Q1j
a bond
Me
a bond
NH
S
NH
T3g
OH


3128
CMe
S
Q1j
a bond
Me
a bond
NH
S
NH
T3h
OH


3129
CMe
S
Q1j
a bond
Me
a bond
NH
S
NH
T3i
OH


3130
CMe
S
Q1j
a bond
Me
a bond
NH
S
NH
T3j
OH


3131
CMe
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3a
OH


3132
CMe
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3b
OH


3133
CMe
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3c
OH


3134
CMe
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3d
OH


3135
CMe
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3e
OH


3136
CMe
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3f
OH


3137
CMe
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3g
OH


3138
CMe
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3h
OH


3139
CMe
S
Q1i
a bond
Me
a bond
NH
S
a bond
T3i
OH


3140
CMe
S
Q1j
a bond
Me
a bond
NH
S
a bond
T3j
OH


3141
CMe
S
Q1j
a bond
Me
a bond
NH
O
NH
T3a
OH


3142
CMe
S
Q1j
a bond
Me
a bond
NH
O
NH
T3b
OH


3143
CMe
S
Q1j
a bond
Me
a bond
NH
O
NH
T3c
OH


3144
CMe
S
Q1j
a bond
Me
a bond
NH
O
NH
T3d
OH


3145
CMe
S
Q1j
a bond
Me
a bond
NH
O
NH
T3e
OH


3146
CMe
S
Q1j
a bond
Me
a bond
NH
O
NH
T3f
OH


3147
CMe
S
Q1j
a bond
Me
a bond
NH
O
NH
T3g
OH


3148
CMe
S
Q1j
a bond
Me
a bond
NH
O
NH
T3h
OH


3149
CMe
S
Q1j
a bond
Me
a bond
NH
O
NH
T3i
OH


3150
CMe
S
Q1j
a bond
Me
a bond
NH
O
NH
T3j
OH


3151
CMe
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3a
OH


3152
CMe
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3b
OH


3153
CMe
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3c
OH


3154
CMe
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3d
OH


3155
CMe
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3e
OH


3156
CMe
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3f
OH


3157
CMe
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3g
OH


3158
CMe
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3h
OH


3159
CMe
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3i
OH


3160
CMe
S
Q1j
a bond
Me
a bond
NH
O
a bond
T3j
OH


3161
CMe
S
Q1j
a bond
H
a bond
NH
S
NH
T3a
OH


3162
CMe
S
Q1j
a bond
H
a bond
NH
S
NH
T3b
OH


3163
CMe
S
Q1j
a bond
H
a bond
NH
S
NH
T3c
OH


3164
CMe
S
Q1j
a bond
H
a bond
NH
S
NH
T3d
OH


3165
CMe
S
Q1j
a bond
H
a bond
NH
S
NH
T3e
OH


3166
CMe
S
Q1j
a bond
H
a bond
NH
S
NH
T3f
OH


3167
CMe
S
Q1j
a bond
H
a bond
NH
S
NH
T3g
OH


3168
CMe
S
Q1j
a bond
H
a bond
NH
S
NH
T3h
OH


3169
CMe
S
Q1j
a bond
H
a bond
NH
S
NH
T3i
OH


3170
CMe
S
Q1j
a bond
H
a bond
NH
S
NH
T3j
OH


3171
CMe
S
Q1j
a bond
H
a bond
NH
S
a bond
T3a
OH


3172
CMe
S
Q1j
a bond
H
a bond
NH
S
a bond
T3b
OH


3173
CMe
S
Q1j
a bond
H
a bond
NH
S
a bond
T3c
OH


3174
CMe
S
Q1j
a bond
H
a bond
NH
S
a bond
T3d
OH


3175
CMe
S
Q1j
a bond
H
a bond
NH
S
a bond
T3e
OH


3176
CMe
S
Q1j
a bond
H
a bond
NH
S
a bond
T3f
OH


3177
CMe
S
Q1j
a bond
H
a bond
NH
S
a bond
T3g
OH


3178
CMe
S
Q1j
a bond
H
a bond
NH
S
a bond
T3h
OH


3179
CMe
S
Q1j
a bond
H
a bond
NH
S
a bond
T3i
OH


3180
CMe
S
Q1j
a bond
H
a bond
NH
S
a bond
T3j
OH


3181
CMe
S
Q1i
a bond
H
a bond
NH
O
NH
T3a
OH


3182
CMe
S
Q1i
a bond
H
a bond
NH
O
NH
T3b
OH


3183
CMe
S
Q1j
a bond
H
a bond
NH
O
NH
T3c
OH


3184
CMe
S
Q1j
a bond
H
a bond
NH
O
NH
T3d
OH


3185
CMe
S
Q1j
a bond
H
a bond
NH
O
NH
T3e
OH


3186
CMe
S
Q1j
a bond
H
a bond
NH
O
NH
T3f
OH


3187
CMe
S
Q1j
a bond
H
a bond
NH
O
NH
T3g
OH


3188
CMe
S
Q1j
a bond
H
a bond
NH
O
NH
T3h
OH


3189
CMe
S
Q1j
a bond
H
a bond
NH
O
NH
T3i
OH


3190
CMe
S
Q1j
a bond
H
a bond
NH
O
NH
T3j
OH


3191
CMe
S
Q1j
a bond
H
a bond
NH
O
a bond
T3a
OH


3192
CMe
S
Q1j
a bond
H
a bond
NH
O
a bond
T3b
OH


3193
CMe
S
Q1j
a bond
H
a bond
NH
O
a bond
T3c
OH


3194
CMe
S
Q1j
a bond
H
a bond
NH
O
a bond
T3d
OH


3195
CMe
S
Q1j
a bond
H
a bond
NH
O
a bond
T3e
OH


3196
CMe
S
Q1j
a bond
H
a bond
NH
O
a bond
T3f
OH


3197
CMe
S
Q1j
a bond
H
a bond
NH
O
a bond
T3g
OH


3198
CMe
S
Q1j
a bond
H
a bond
NH
O
a bond
T3h
OH


3199
CMe
S
Q1j
a bond
H
a bond
NH
O
a bond
T3i
OH


3200
CMe
S
Q1j
a bond
H
a bond
NH
O
a bond
T3j
OH


3201
CMe
O
Q1a
a bond
Me
a bond
NH
S
NH
T3a
OH


3202
CMe
O
Q1a
a bond
Me
a bond
NH
S
NH
T3b
OH


3203
CMe
O
Q1a
a bond
Me
a bond
NH
S
NH
T3c
OH


3204
CMe
O
Q1a
a bond
Me
a bond
NH
S
NH
T3d
OH


3205
CMe
O
Q1a
a bond
Me
a bond
NH
S
NH
T3e
OH


3206
CMe
O
Q1a
a bond
Me
a bond
NH
S
NH
T3f
OH


3207
CMe
O
Q1a
a bond
Me
a bond
NH
S
NH
T3g
OH


3208
CMe
O
Q1a
a bond
Me
a bond
NH
S
NH
T3h
OH


3209
CMe
O
Q1a
a bond
Me
a bond
NH
S
NH
T3i
OH


3210
CMe
O
Q1a
a bond
Me
a bond
NH
S
NH
T3j
OH


3211
CMe
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3a
OH


3212
CMe
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3b
OH


3213
CMe
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3c
OH


3214
CMe
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3d
OH


3215
CMe
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3e
OH


3216
CMe
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3f
OH


3217
CMe
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3g
OH


3218
CMe
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3h
OH


3219
CMe
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3i
OH


3220
CMe
O
Q1a
a bond
Me
a bond
NH
S
a bond
T3j
OH


3221
CMe
O
Q1a
a bond
Me
a bond
NH
O
NH
T3a
OH


3222
CMe
O
Q1a
a bond
Me
a bond
NH
O
NH
T3b
OH


3223
CMe
O
Q1a
a bond
Me
a bond
NH
O
NH
T3c
OH


3224
CMe
O
Q1a
a bond
Me
a bond
NH
O
NH
T3d
OH


3225
CMe
O
Q1a
a bond
Me
a bond
NH
O
NH
T3e
OH


3226
CMe
O
Q1a
a bond
Me
a bond
NH
O
NH
T3f
OH


3227
CMe
O
Q1a
a bond
Me
a bond
NH
O
NH
T3g
OH


3228
CMe
O
Q1a
a bond
Me
a bond
NH
O
NH
T3h
OH


3229
CMe
O
Q1a
a bond
Me
a bond
NH
O
NH
T3i
OH


3230
CMe
O
Q1a
a bond
Me
a bond
NH
O
NH
T3j
OH


3231
CMe
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3a
OH


3232
CMe
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3b
OH


3233
CMe
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3c
OH


3234
CMe
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3d
OH


3235
CMe
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3e
OH


3236
CMe
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3f
OH


3237
CMe
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3g
OH


3238
CMe
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3h
OH


3239
CMe
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3i
OH


3240
CMe
O
Q1a
a bond
Me
a bond
NH
O
a bond
T3j
OH


3241
CMe
O
Q1a
a bond
H
a bond
NH
S
NH
T3a
OH


3242
CMe
O
Q1a
a bond
H
a bond
NH
S
NH
T3b
OH


3243
CMe
O
Q1a
a bond
H
a bond
NH
S
NH
T3c
OH


3244
CMe
O
Q1a
a bond
H
a bond
NH
S
NH
T3d
OH


3245
CMe
O
Q1a
a bond
H
a bond
NH
S
NH
T3e
OH


3246
CMe
O
Q1a
a bond
H
a bond
NH
S
NH
T3f
OH


3247
CMe
O
Q1a
a bond
H
a bond
NH
S
NH
T3g
OH


3248
CMe
O
Q1a
a bond
H
a bond
NH
S
NH
T3h
OH


3249
CMe
O
Q1a
a bond
H
a bond
NH
S
NH
T3i
OH


3250
CMe
O
Q1a
a bond
H
a bond
NH
S
NH
T3j
OH


3251
CMe
O
Q1a
a bond
H
a bond
NH
S
a bond
T3a
OH


3252
CMe
O
Q1a
a bond
H
a bond
NH
S
a bond
T3b
OH


3253
CMe
O
Q1a
a bond
H
a bond
NH
S
a bond
T3c
OH


3254
CMe
O
Q1a
a bond
H
a bond
NH
S
a bond
T3d
OH


3255
CMe
O
Q1a
a bond
H
a bond
NH
S
a bond
T3e
OH


3256
CMe
O
Q1a
a bond
H
a bond
NH
S
a bond
T3f
OH


3257
CMe
O
Q1a
a bond
H
a bond
NH
S
a bond
T3g
OH


3258
CMe
O
Q1a
a bond
H
a bond
NH
S
a bond
T3h
OH


3259
CMe
O
Q1a
a bond
H
a bond
NH
S
a bond
T3i
OH


3260
CMe
O
Q1a
a bond
H
a bond
NH
S
a bond
T3j
OH


3261
CMe
O
Q1a
a bond
H
a bond
NH
O
NH
T3a
OH


3262
CMe
O
Q1a
a bond
H
a bond
NH
O
NH
T3b
OH


3263
CMe
O
Q1a
a bond
H
a bond
NH
O
NH
T3c
OH


3264
CMe
O
Q1a
a bond
H
a bond
NH
O
NH
T3d
OH


3265
CMe
O
Q1a
a bond
H
a bond
NH
O
NH
T3e
OH


3266
CMe
O
Q1a
a bond
H
a bond
NH
O
NH
T3f
OH


3267
CMe
O
Q1a
a bond
H
a bond
NH
O
NH
T3g
OH


3268
CMe
O
Q1a
a bond
H
a bond
NH
O
NH
T3h
OH


3269
CMe
O
Q1a
a bond
H
a bond
NH
O
NH
T3i
OH


3270
CMe
O
Q1a
a bond
H
a bond
NH
O
NH
T3j
OH


3271
CMe
O
Q1a
a bond
H
a bond
NH
O
a bond
T3a
OH


3272
CMe
O
Q1a
a bond
H
a bond
NH
O
a bond
T3b
OH


3273
CMe
O
Q1a
a bond
H
a bond
NH
O
a bond
T3c
OH


3274
CMe
O
Q1a
a bond
H
a bond
NH
O
a bond
T3d
OH


3275
CMe
O
Q1a
a bond
H
a bond
NH
O
a bond
T3e
OH


3276
CMe
O
Q1a
a bond
H
a bond
NH
O
a bond
T3f
OH


3277
CMe
O
Q1a
a bond
H
a bond
NH
O
a bond
T3g
OH


3278
CMe
O
Q1a
a bond
H
a bond
NH
O
a bond
T3h
OH


3279
CMe
O
Q1a
a bond
H
a bond
NH
O
a bond
T3i
OH


3280
CMe
O
Q1a
a bond
H
a bond
NH
O
a bond
T3j
OH


3281
CMe
O
Q1b
a bond
Me
a bond
NH
S
NH
T3a
OH


3282
CMe
O
Q1b
a bond
Me
a bond
NH
S
NH
T3b
OH


3283
CMe
O
Q1b
a bond
Me
a bond
NH
S
NH
T3c
OH


3284
CMe
O
Q1b
a bond
Me
a bond
NH
S
NH
T3d
OH


3285
CMe
O
Q1b
a bond
Me
a bond
NH
S
NH
T3e
OH


3286
CMe
O
Q1b
a bond
Me
a bond
NH
S
NH
T3f
OH


3287
CMe
O
Q1b
a bond
Me
a bond
NH
S
NH
T3g
OH


3288
CMe
O
Q1b
a bond
Me
a bond
NH
S
NH
T3h
OH


3289
CMe
O
Q1b
a bond
Me
a bond
NH
S
NH
T3i
OH


3290
CMe
O
Q1b
a bond
Me
a bond
NH
S
NH
T3j
OH


3291
CMe
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3a
OH


3292
CMe
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3b
OH


3293
CMe
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3c
OH


3294
CMe
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3d
OH


3295
CMe
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3e
OH


3296
CMe
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3f
OH


3297
CMe
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3g
OH


3298
CMe
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3h
OH


3299
CMe
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3i
OH


3300
CMe
O
Q1b
a bond
Me
a bond
NH
S
a bond
T3j
OH


3301
CMe
O
Q1b
a bond
Me
a bond
NH
O
NH
T3a
OH


3302
CMe
O
Q1b
a bond
Me
a bond
NH
O
NH
T3b
OH


3303
CMe
O
Q1b
a bond
Me
a bond
NH
O
NH
T3c
OH


3304
CMe
O
Q1b
a bond
Me
a bond
NH
O
NH
T3d
OH


3305
CMe
O
Q1b
a bond
Me
a bond
NH
O
NH
T3e
OH


3306
CMe
O
Q1b
a bond
Me
a bond
NH
O
NH
T3f
OH


3307
CMe
O
Q1b
a bond
Me
a bond
NH
O
NH
T3g
OH


3308
CMe
O
Q1b
a bond
Me
a bond
NH
O
NH
T3h
OH


3309
CMe
O
Q1b
a bond
Me
a bond
NH
O
NH
T3i
OH


3310
CMe
O
Q1b
a bond
Me
a bond
NH
O
NH
T3j
OH


3311
CMe
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3a
OH


3312
CMe
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3b
OH


3313
CMe
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3c
OH


3314
CMe
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3d
OH


3315
CMe
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3e
OH


3316
CMe
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3f
OH


3317
CMe
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3g
OH


3318
CMe
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3h
OH


3319
CMe
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3i
OH


3320
CMe
O
Q1b
a bond
Me
a bond
NH
O
a bond
T3j
OH


3321
CMe
O
Q1b
a bond
H
a bond
NH
S
NH
T3a
OH


3322
CMe
O
Q1b
a bond
H
a bond
NH
S
NH
T3b
OH


3323
CMe
O
Q1b
a bond
H
a bond
NH
S
NH
T3c
OH


3324
CMe
O
Q1b
a bond
H
a bond
NH
S
NH
T3d
OH


3325
CMe
O
Q1b
a bond
H
a bond
NH
S
NH
T3e
OH


3326
CMe
O
Q1b
a bond
H
a bond
NH
S
NH
T3f
OH


3327
CMe
O
Q1b
a bond
H
a bond
NH
S
NH
T3g
OH


3328
CMe
O
Q1b
a bond
H
a bond
NH
S
NH
T3h
OH


3329
CMe
O
Q1b
a bond
H
a bond
NH
S
NH
T3i
OH


3330
CMe
O
Q1b
a bond
H
a bond
NH
S
NH
T3j
OH


3331
CMe
O
Q1b
a bond
H
a bond
NH
S
a bond
T3a
OH


3332
CMe
O
Q1b
a bond
H
a bond
NH
S
a bond
T3b
OH


3333
CMe
O
Q1b
a bond
H
a bond
NH
S
a bond
T3c
OH


3334
CMe
O
Q1b
a bond
H
a bond
NH
S
a bond
T3d
OH


3335
CMe
O
Q1b
a bond
H
a bond
NH
S
a bond
T3e
OH


3336
CMe
O
Q1b
a bond
H
a bond
NH
S
a bond
T3f
OH


3337
CMe
O
Q1b
a bond
H
a bond
NH
S
a bond
T3g
OH


3338
CMe
O
Q1b
a bond
H
a bond
NH
S
a bond
T3h
OH


3339
CMe
O
Q1b
a bond
H
a bond
NH
S
a bond
T3i
OH


3340
CMe
O
Q1b
a bond
H
a bond
NH
S
a bond
T3j
OH


3341
CMe
O
Q1b
a bond
H
a bond
NH
O
NH
T3a
OH


3342
CMe
O
Q1b
a bond
H
a bond
NH
O
NH
T3b
OH


3343
CMe
O
Q1b
a bond
H
a bond
NH
O
NH
T3c
OH


3344
CMe
O
Q1b
a bond
H
a bond
NH
O
NH
T3d
OH


3345
CMe
O
Q1b
a bond
H
a bond
NH
O
NH
T3e
OH


3346
CMe
O
Q1b
a bond
H
a bond
NH
O
NH
T3f
OH


3347
CMe
O
Q1b
a bond
H
a bond
NH
O
NH
T3g
OH


3348
CMe
O
Q1b
a bond
H
a bond
NH
O
NH
T3h
OH


3349
CMe
O
Q1b
a bond
H
a bond
NH
O
NH
T3i
OH


3350
CMe
O
Q1b
a bond
H
a bond
NH
O
NH
T3j
OH


3351
CMe
O
Q1b
a bond
H
a bond
NH
O
a bond
T3a
OH


3352
CMe
O
Q1b
a bond
H
a bond
NH
O
a bond
T3b
OH


3353
CMe
O
Q1b
a bond
H
a bond
NH
O
a bond
T3c
OH


3354
CMe
O
Q1b
a bond
H
a bond
NH
O
a bond
T3d
OH


3355
CMe
O
Q1b
a bond
H
a bond
NH
O
a bond
T3e
OH


3356
CMe
O
Q1b
a bond
H
a bond
NH
O
a bond
T3f
OH


3357
CMe
O
Q1b
a bond
H
a bond
NH
O
a bond
T3g
OH


3358
CMe
O
Q1b
a bond
H
a bond
NH
O
a bond
T3h
OH


3359
CMe
O
Q1b
a bond
H
a bond
NH
O
a bond
T3i
OH


3360
CMe
O
Q1b
a bond
H
a bond
NH
O
a bond
T3j
OH


3361
CMe
O
Q1c
a bond
Me
a bond
NH
S
NH
T3a
OH


3362
CMe
O
Q1c
a bond
Me
a bond
NH
S
NH
T3b
OH


3363
CMe
O
Q1c
a bond
Me
a bond
NH
S
NH
T3c
OH


3364
CMe
O
Q1c
a bond
Me
a bond
NH
S
NH
T3d
OH


3365
CMe
O
Q1c
a bond
Me
a bond
NH
S
NH
T3e
OH


3366
CMe
O
Q1c
a bond
Me
a bond
NH
S
NH
T3f
OH


3367
CMe
O
Q1c
a bond
Me
a bond
NH
S
NH
T3g
OH


3368
CMe
O
Q1c
a bond
Me
a bond
NH
S
NH
T3h
OH


3369
CMe
O
Q1c
a bond
Me
a bond
NH
S
NH
T3i
OH


3370
CMe
O
Q1c
a bond
Me
a bond
NH
S
NH
T3j
OH


3371
CMe
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3a
OH


3372
CMe
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3b
OH


3373
CMe
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3c
OH


3374
CMe
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3d
OH


3375
CMe
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3e
OH


3376
CMe
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3f
OH


3377
CMe
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3g
OH


3378
CMe
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3h
OH


3379
CMe
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3i
OH


3380
CMe
O
Q1c
a bond
Me
a bond
NH
S
a bond
T3j
OH


3381
CMe
O
Q1c
a bond
Me
a bond
NH
O
NH
T3a
OH


3382
CMe
O
Q1c
a bond
Me
a bond
NH
O
NH
T3b
OH


3383
CMe
O
Q1c
a bond
Me
a bond
NH
O
NH
T3c
OH


3384
CMe
O
Q1c
a bond
Me
a bond
NH
O
NH
T3d
OH


3385
CMe
O
Q1c
a bond
Me
a bond
NH
O
NH
T3e
OH


3386
CMe
O
Q1c
a bond
Me
a bond
NH
O
NH
T3f
OH


3387
CMe
O
Q1c
a bond
Me
a bond
NH
O
NH
T3g
OH


3388
CMe
O
Q1c
a bond
Me
a bond
NH
O
NH
T3h
OH


3389
CMe
O
Q1c
a bond
Me
a bond
NH
O
NH
T3i
OH


3390
CMe
O
Q1c
a bond
Me
a bond
NH
O
NH
T3j
OH


3391
CMe
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3a
OH


3392
CMe
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3b
OH


3393
CMe
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3c
OH


3394
CMe
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3d
OH


3395
CMe
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3e
OH


3396
CMe
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3f
OH


3397
CMe
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3g
OH


3398
CMe
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3h
OH


3399
CMe
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3i
OH


3400
CMe
O
Q1c
a bond
Me
a bond
NH
O
a bond
T3j
OH


3401
CMe
O
Q1c
a bond
H
a bond
NH
S
NH
T3a
OH


3402
CMe
O
Q1c
a bond
H
a bond
NH
S
NH
T3b
OH


3403
CMe
O
Q1c
a bond
H
a bond
NH
S
NH
T3c
OH


3404
CMe
O
Q1c
a bond
H
a bond
NH
S
NH
T3d
OH


3405
CMe
O
Q1c
a bond
H
a bond
NH
S
NH
T3e
OH


3406
CMe
O
Q1c
a bond
H
a bond
NH
S
NH
T3f
OH


3407
CMe
O
Q1c
a bond
H
a bond
NH
S
NH
T3g
OH


3408
CMe
O
Q1c
a bond
H
a bond
NH
S
NH
T3h
OH


3409
CMe
O
Q1c
a bond
H
a bond
NH
S
NH
T3i
OH


3410
CMe
O
Q1c
a bond
H
a bond
NH
S
NH
T3j
OH


3411
CMe
O
Q1c
a bond
H
a bond
NH
S
a bond
T3a
OH


3412
CMe
O
Q1c
a bond
H
a bond
NH
S
a bond
T3b
OH


3413
CMe
O
Q1c
a bond
H
a bond
NH
S
a bond
T3c
OH


3414
CMe
O
Q1c
a bond
H
a bond
NH
S
a bond
T3d
OH


3415
CMe
O
Q1c
a bond
H
a bond
NH
S
a bond
T3e
OH


3416
CMe
O
Q1c
a bond
H
a bond
NH
S
a bond
T3f
OH


3417
CMe
O
Q1c
a bond
H
a bond
NH
S
a bond
T3g
OH


3418
CMe
O
Q1c
a bond
H
a bond
NH
S
a bond
T3h
OH


3419
CMe
O
Q1c
a bond
H
a bond
NH
S
a bond
T3i
OH


3420
CMe
O
Q1c
a bond
H
a bond
NH
S
a bond
T3j
OH


3421
CMe
O
Q1c
a bond
H
a bond
NH
O
NH
T3a
OH


3422
CMe
O
Q1c
a bond
H
a bond
NH
O
NH
T3b
OH


3423
CMe
O
Q1c
a bond
H
a bond
NH
O
NH
T3c
OH


3424
CMe
O
Q1c
a bond
H
a bond
NH
O
NH
T3d
OH


3425
CMe
O
Q1c
a bond
H
a bond
NH
O
NH
T3e
OH


3426
CMe
O
Q1c
a bond
H
a bond
NH
O
NH
T3f
OH


3427
CMe
O
Q1c
a bond
H
a bond
NH
O
NH
T3g
OH


3428
CMe
O
Q1c
a bond
H
a bond
NH
O
NH
T3h
OH


3429
CMe
O
Q1c
a bond
H
a bond
NH
O
NH
T3i
OH


3430
CMe
O
Q1c
a bond
H
a bond
NH
O
NH
T3j
OH


3431
CMe
O
Q1c
a bond
H
a bond
NH
O
a bond
T3a
OH


3432
CMe
O
Q1c
a bond
H
a bond
NH
O
a bond
T3b
OH


3433
CMe
O
Q1c
a bond
H
a bond
NH
O
a bond
T3c
OH


3434
CMe
O
Q1c
a bond
H
a bond
NH
O
a bond
T3d
OH


3435
CMe
O
Q1c
a bond
H
a bond
NH
O
a bond
T3e
OH


3436
CMe
O
Q1c
a bond
H
a bond
NH
O
a bond
T3f
OH


3437
CMe
O
Q1c
a bond
H
a bond
NH
O
a bond
T3g
OH


3438
CMe
O
Q1c
a bond
H
a bond
NH
O
a bond
T3h
OH


3439
CMe
O
Q1c
a bond
H
a bond
NH
O
a bond
T3i
OH


3440
CMe
O
Q1c
a bond
H
a bond
NH
O
a bond
T3j
OH


3441
CMe
O
Q1i
a bond
Me
a bond
NH
S
NH
T3a
OH


3442
CMe
O
Q1i
a bond
Me
a bond
NH
S
NH
T3b
OH


3443
CMe
O
Q1i
a bond
Me
a bond
NH
S
NH
T3c
OH


3444
CMe
O
Q1i
a bond
Me
a bond
NH
S
NH
T3d
OH


3445
CMe
O
Q1i
a bond
Me
a bond
NH
S
NH
T3e
OH


3446
CMe
O
Q1i
a bond
Me
a bond
NH
S
NH
T3f
OH


3447
CMe
O
Q1i
a bond
Me
a bond
NH
S
NH
T3g
OH


3448
CMe
O
Q1i
a bond
Me
a bond
NH
S
NH
T3h
OH


3449
CMe
O
Q1i
a bond
Me
a bond
NH
S
NH
T3i
OH


3450
CMe
O
Q1i
a bond
Me
a bond
NH
S
NH
T3j
OH


3451
CMe
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3a
OH


3452
CMe
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3b
OH


3453
CMe
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3c
OH


3454
CMe
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3d
OH


3455
CMe
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3e
OH


3456
CMe
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3f
OH


3457
CMe
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3g
OH


3458
CMe
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3h
OH


3459
CMe
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3i
OH


3460
CMe
O
Q1i
a bond
Me
a bond
NH
S
a bond
T3j
OH


3461
CMe
O
Q1i
a bond
Me
a bond
NH
O
NH
T3a
OH


3462
CMe
O
Q1i
a bond
Me
a bond
NH
O
NH
T3b
OH


3463
CMe
O
Q1i
a bond
Me
a bond
NH
O
NH
T3c
OH


3464
CMe
O
Q1i
a bond
Me
a bond
NH
O
NH
T3d
OH


3465
CMe
O
Q1i
a bond
Me
a bond
NH
O
NH
T3e
OH


3466
CMe
O
Q1i
a bond
Me
a bond
NH
O
NH
T3f
OH


3467
CMe
O
Q1i
a bond
Me
a bond
NH
O
NH
T3g
OH


3468
CMe
O
Q1i
a bond
Me
a bond
NH
O
NH
T3h
OH


3469
CMe
O
Q1i
a bond
Me
a bond
NH
O
NH
T3i
OH


3470
CMe
O
Q1i
a bond
Me
a bond
NH
O
NH
T3j
OH


3471
CMe
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3a
OH


3472
CMe
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3b
OH


3473
CMe
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3c
OH


3474
CMe
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3d
OH


3475
CMe
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3e
OH


3476
CMe
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3f
OH


3477
CMe
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3g
OH


3478
CMe
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3h
OH


3479
CMe
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3i
OH


3480
CMe
O
Q1i
a bond
Me
a bond
NH
O
a bond
T3j
OH


3481
CMe
O
Q1i
a bond
H
a bond
NH
S
NH
T3a
OH


3482
CMe
O
Q1i
a bond
H
a bond
NH
S
NH
T3b
OH


3483
CMe
O
Q1i
a bond
H
a bond
NH
S
NH
T3c
OH


3484
CMe
O
Q1i
a bond
H
a bond
NH
S
NH
T3d
OH


3485
CMe
O
Q1i
a bond
H
a bond
NH
S
NH
T3e
OH


3486
CMe
O
Q1i
a bond
H
a bond
NH
S
NH
T3f
OH


3487
CMe
O
Q1i
a bond
H
a bond
NH
S
NH
T3g
OH


3488
CMe
O
Q1i
a bond
H
a bond
NH
S
NH
T3h
OH


3489
CMe
O
Q1i
a bond
H
a bond
NH
S
NH
T3i
OH


3490
CMe
O
Q1i
a bond
H
a bond
NH
S
NH
T3j
OH


3491
CMe
O
Q1i
a bond
H
a bond
NH
S
a bond
T3a
OH


3492
CMe
O
Q1i
a bond
H
a bond
NH
S
a bond
T3b
OH


3493
CMe
O
Q1i
a bond
H
a bond
NH
S
a bond
T3c
OH


3494
CMe
O
Q1i
a bond
H
a bond
NH
S
a bond
T3d
OH


3495
CMe
O
Q1i
a bond
H
a bond
NH
S
a bond
T3e
OH


3496
CMe
O
Q1i
a bond
H
a bond
NH
S
a bond
T3f
OH


3497
CMe
O
Q1i
a bond
H
a bond
NH
S
a bond
T3g
OH


3498
CMe
O
Q1i
a bond
H
a bond
NH
S
a bond
T3h
OH


3499
CMe
O
Q1i
a bond
H
a bond
NH
S
a bond
T3i
OH


3500
CMe
O
Q1i
a bond
H
a bond
NH
S
a bond
T3j
OH


3501
CMe
O
Q1i
a bond
H
a bond
NH
O
NH
T3a
OH


3502
CMe
O
Q1i
a bond
H
a bond
NH
O
NH
T3b
OH


3503
CMe
O
Q1i
a bond
H
a bond
NH
O
NH
T3c
OH


3504
CMe
O
Q1i
a bond
H
a bond
NH
O
NH
T3d
OH


3505
CMe
O
Q1i
a bond
H
a bond
NH
O
NH
T3e
OH


3506
CMe
O
Q1i
a bond
H
a bond
NH
O
NH
T3f
OH


3507
CMe
O
Q1i
a bond
H
a bond
NH
O
NH
T3g
OH


3508
CMe
O
Q1i
a bond
H
a bond
NH
O
NH
T3h
OH


3509
CMe
O
Q1i
a bond
H
a bond
NH
O
NH
T3i
OH


3510
CMe
O
Q1i
a bond
H
a bond
NH
O
NH
T3j
OH


3511
CMe
O
Q1i
a bond
H
a bond
NH
O
a bond
T3a
OH


3512
CMe
O
Q1i
a bond
H
a bond
NH
O
a bond
T3b
OH


3513
CMe
O
Q1i
a bond
H
a bond
NH
O
a bond
T3c
OH


3514
CMe
O
Q1i
a bond
H
a bond
NH
O
a bond
T3d
OH


3515
CMe
O
Q1i
a bond
H
a bond
NH
O
a bond
T3e
OH


3516
CMe
O
Q1i
a bond
H
a bond
NH
O
a bond
T3f
OH


3517
CMe
O
Q1i
a bond
H
a bond
NH
O
a bond
T3g
OH


3518
CMe
O
Q1i
a bond
H
a bond
NH
O
a bond
T3h
OH


3519
CMe
O
Q1i
a bond
H
a bond
NH
O
a bond
T3i
OH


3520
CMe
O
Q1i
a bond
H
a bond
NH
O
a bond
T3j
OH


3521
CMe
O
Q1j
a bond
Me
a bond
NH
S
NH
T3a
OH


3522
CMe
O
Q1j
a bond
Me
a bond
NH
S
NH
T3b
OH


3523
CMe
O
Q1j
a bond
Me
a bond
NH
S
NH
T3c
OH


3524
CMe
O
Q1j
a bond
Me
a bond
NH
S
NH
T3d
OH


3525
CMe
O
Q1j
a bond
Me
a bond
NH
S
NH
T3e
OH


3526
CMe
O
Q1j
a bond
Me
a bond
NH
S
NH
T3f
OH


3527
CMe
O
Q1j
a bond
Me
a bond
NH
S
NH
T3g
OH


3528
CMe
O
Q1j
a bond
Me
a bond
NH
S
NH
T3h
OH


3529
CMe
O
Q1j
a bond
Me
a bond
NH
S
NH
T3i
OH


3530
CMe
O
Q1j
a bond
Me
a bond
NH
S
NH
T3j
OH


3531
CMe
O
Q1j
a bond
Me
a bond
NH
S
a bond
T3a
OH


3532
CMe
O
Q1j
a bond
Me
a bond
NH
S
a bond
T3b
OH


3533
CMe
O
Q1j
a bond
Me
a bond
NH
S
a bond
T3c
OH


3534
CMe
O
Q1j
a bond
Me
a bond
NH
S
a bond
T3d
OH


3535
CMe
O
Q1j
a bond
Me
a bond
NH
S
a bond
T3e
OH


3536
CMe
O
Q1j
a bond
Me
a bond
NH
S
a bond
T3f
OH


3537
CMe
O
Q1j
a bond
Me
a bond
NH
S
a bond
T3g
OH


3538
CMe
O
Q1j
a bond
Me
a bond
NH
S
a bond
T3h
OH


3539
CMe
O
Q1j
a bond
Me
a bond
NH
S
a bond
T3i
OH


3540
CMe
O
Q1j
a bond
Me
a bond
NH
S
a bond
T3j
OH


3541
CMe
O
Q1j
a bond
Me
a bond
NH
O
NH
T3a
OH


3542
CMe
O
Q1j
a bond
Me
a bond
NH
O
NH
T3b
OH


3543
CMe
O
Q1i
a bond
Me
a bond
NH
O
NH
T3c
OH


3544
CMe
O
Q1j
a bond
Me
a bond
NH
O
NH
T3d
OH


3545
CMe
O
Q1j
a bond
Me
a bond
NH
O
NH
T3e
OH


3546
CMe
O
Q1j
a bond
Me
a bond
NH
O
NH
T3f
OH


3547
CMe
O
Q1j
a bond
Me
a bond
NH
O
NH
T3g
OH


3548
CMe
O
Q1j
a bond
Me
a bond
NH
O
NH
T3h
OH


3549
CMe
O
Q1j
a bond
Me
a bond
NH
O
NH
T3i
OH


3550
CMe
O
Q1j
a bond
Me
a bond
NH
O
NH
T3.j
OH


3551
CMe
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3a
OH


3552
CMe
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3b
OH


3553
CMe
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3c
OH


3554
CMe
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3d
OH


3555
CMe
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3e
OH


3556
CMe
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3f
OH


3557
CMe
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3g
OH


3558
CMe
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3h
OH


3559
CMe
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3i
OH


3560
CMe
O
Q1j
a bond
Me
a bond
NH
O
a bond
T3j
OH


3561
CMe
O
Q1j
a bond
H
a bond
NH
S
NH
T3a
OH


3562
CMe
O
Q1j
a bond
H
a bond
NH
S
NH
T3b
OH


3563
CMe
O
Q1j
a bond
H
a bond
NH
S
NH
T3c
OH


3564
CMe
O
Q1j
a bond
H
a bond
NH
S
NH
T3d
OH


3565
CMe
O
Q1j
a bond
H
a bond
NH
S
NH
T3e
OH


3566
CMe
O
Q1j
a bond
H
a bond
NH
S
NH
T3f
OH


3567
CMe
O
Q1j
a bond
H
a bond
NH
S
NH
T3g
OH


3568
CMe
O
Q1j
a bond
H
a bond
NH
S
NH
T3h
OH


3569
CMe
O
Q1j
a bond
H
a bond
NH
S
NH
T3i
OH


3570
CMe
O
Q1j
a bond
H
a bond
NH
S
NH
T3j
OH


3571
CMe
O
Q1j
a bond
H
a bond
NH
S
a bond
T3a
OH


3572
CMe
O
Q1j
a bond
H
a bond
NH
S
a bond
T3b
OH


3573
CMe
O
Q1j
a bond
H
a bond
NH
S
a bond
T3c
OH


3574
CMe
O
Q1j
a bond
H
a bond
NH
S
a bond
T3d
OH


3575
CMe
O
Q1j
a bond
H
a bond
NH
S
a bond
T3e
OH


3576
CMe
O
Q1j
a bond
H
a bond
NH
S
a bond
T3f
OH


3577
CMe
O
Q1j
a bond
H
a bond
NH
S
a bond
T3g
OH


3578
CMe
O
Q1j
a bond
H
a bond
NH
S
a bond
T3h
OH


3579
CMe
O
Q1j
a bond
H
a bond
NH
S
a bond
T3i
OH


3580
CMe
O
Q1j
a bond
H
a bond
NH
S
a bond
T3j
OH


3581
CMe
O
Q1j
a bond
H
a bond
NH
O
NH
T3a
OH


3582
CMe
O
Q1j
a bond
H
a bond
NH
O
NH
T3b
OH


3583
CMe
O
Q1j
a bond
H
a bond
NH
O
NH
T3c
OH


3584
CMe
O
Q1i
a bond
H
a bond
NH
O
NH
T3d
OH


3585
CMe
O
Q1j
a bond
H
a bond
NH
O
NH
T3e
OH


3586
CMe
O
Q1j
a bond
H
a bond
NH
O
NH
T3f
OH


3587
CMe
O
Q1j
a bond
H
a bond
NH
O
NH
T3g
OH


3588
CMe
O
Q1j
a bond
H
a bond
NH
O
NH
T3h
OH


3589
CMe
O
Q1j
a bond
H
a bond
NH
O
NH
T3i
OH


3590
CMe
O
Q1i
a bond
H
a bond
NH
O
NH
T3j
OH


3591
CMe
O
Q1i
a bond
H
a bond
NH
O
a bond
T3a
OH


3592
CMe
O
Q1j
a bond
H
a bond
NH
O
a bond
T3b
OH


3593
CMe
O
Q1j
a bond
H
a bond
NH
O
a bond
T3c
OH


3594
CMe
O
Q1j
a bond
H
a bond
NH
O
a bond
T3d
OH


3595
CMe
O
Q1j
a bond
H
a bond
NH
O
a bond
T3e
OH


3596
CMe
O
Q1j
a bond
H
a bond
NH
O
a bond
T3f
OH


3597
CMe
O
Q1j
a bond
H
a bond
NH
O
a bond
T3g
OH


3598
CMe
O
Q1j
a bond
H
a bond
NH
O
a bond
T3h
OH


3599
CMe
O
Q1j
a bond
H
a bond
NH
O
a bond
T3i
OH


3600
CMe
O
Q1j
a bond
H
a bond
NH
O
a bond
T3j
OH


3601
N
NMe
Q1i
a bond
Me
a bond
NH
S
NH
Q3e
OH


3602
N
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3603
N
NMe
Q1i
a bond
Me
a bond
NH
O
NH
Q3e
OH


3604
N
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3605
N
NMe
Q1i
a bond
H
a bond
NH
S
NH
Q3e
OH


3606
N
NMe
Q1i
a bond
H
a bond
NH
S
a bond
Q3e
OH


3607
N
NMe
Q1i
a bond
H
a bond
NH
O
NH
Q3e
OH


3608
N
NMe
Q1i
a bond
H
a bond
NH
O
a bond
Q3e
OH


3609
N
NMe
Q1j
a bond
Me
a bond
NH
S
NH
Q3e
OH


3610
N
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3611
N
NMe
Q1j
a bond
Me
a bond
NH
O
NH
Q3e
OH


3612
N
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3613
N
NMe
Q1j
a bond
H
a bond
NH
S
NH
Q3e
OH


3614
N
NMe
Q1j
a bond
H
a bond
NH
S
a bond
Q3e
OH


3615
N
NMe
Q1j
a bond
H
a bond
NH
O
NH
Q3e
OH


3616
N
NMe
Q1j
a bond
H
a bond
NH
O
a bond
Q3e
OH


3617
N
S
Q1i
a bond
Me
a bond
NH
S
NH
Q3e
OH


3618
N
S
Q1i
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3619
N
S
Q1i
a bond
Me
a bond
NH
O
NH
Q3e
OH


3620
N
S
Q1i
a bond
Me
a bond
NH
O
a bondQ3eOH


3621
N
S
Q1i
a bond
H
a bond
NH
S
NH
Q3e
OH


3622
N
S
Q1i
a bond
H
a bond
NH
S
a bond
Q3e
OH


3623
N
S
Q1i
a bond
H
a bond
NH
O
NH
Q3e
OH


3624
N
S
Q1i
a bond
H
a bond
NH
O
a bond
Q3e
OH


3625
N
S
Q1j
a bond
Me
a bond
NH
S
NH
Q3e
OH


3626
N
S
Q1j
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3627
N
S
Q1j
a bond
Me
a bond
NH
O
NH
Q3e
OH


3628
N
S
Q1j
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3629
N
S
Q1j
a bond
H
a bond
NH
S
NH
Q3e
OH


3630
N
S
Q1j
a bond
H
a bond
NH
S
a bond
Q3e
OH


3631
N
S
Q1j
a bond
H
a bond
NH
O
NH
Q3e
OH


3632
N
S
Q1j
a bond
H
a bond
NH
O
a bond
Q3e
OH


3633
N
O
Q1i
a bond
Me
a bond
NH
S
NH
Q3e
OH


3634
N
O
Q1i
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3635
N
O
Q1i
a bond
Me
a bond
NH
O
NH
Q3e
OH


3636
N
O
Q1i
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3637
N
O
Q1i
a bond
H
a bond
NH
S
NH
Q3e
OH


3638
N
O
Q1i
a bond
H
a bond
NH
S
a bond
Q3e
OH


3639
N
O
Q1i
a bond
H
a bond
NH
O
NH
Q3e
OH


3640
N
O
Q1i
a bond
H
a bond
NH
O
a bond
Q3e
OH


3641
N
O
Q1j
a bond
Me
a bond
NH
S
NH
Q3e
OH


3642
N
O
Q1j
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3643
N
O
Q1j
a bond
Me
a bond
NH
O
NH
Q3e
OH


3644
N
O
Q1j
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3645
N
O
Q1j
a bond
H
a bond
NH
S
NH
Q3e
OH


3646
N
O
Q1j
a bond
H
a bond
NH
S
a bond
Q3e
OH


3647
N
O
Q1j
a bond
H
a bond
NH
O
NH
Q3e
OH


3648
N
O
Q1i
a bond
H
a bond
NH
O
a bond
Q3e
OH


3649
CH
NMe
Q1i
a bond
Me
a bond
NH
S
NH
Q3e
OH


3650
CH
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3651
CH
NMe
Q1i
a bond
Me
a bond
NH
O
NH
Q3e
OH


3652
CH
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3653
CH
NMe
Q1i
a bond
H
a bond
NH
S
NH
Q3e
OH


3654
CH
NMe
Q1i
a bond
H
a bond
NH
S
a bond
Q3e
OH


3655
CH
NMe
Q1i
a bond
H
a bond
NH
O
NH
Q3e
OH


3656
CH
NMe
Q1i
a bond
H
a bond
NH
O
a bond
Q3e
OH


3657
CH
NMe
Q1j
a bond
Me
a bond
NH
S
NH
Q3e
OH


3658
CH
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3659
CH
NMe
Q1j
a bond
Me
a bond
NH
O
NH
Q3e
OH


3660
CH
NMe
Q1j
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3661
CH
NMe
Q1j
a bond
H
a bond
NH
S
NH
Q3e
OH


3662
CH
NMe
Q1j
a bond
H
a bond
NH
S
a bond
Q3e
OH


3663
CH
NMe
Q1j
a bond
H
a bond
NH
O
NH
Q3e
OH


3664
CH
NMe
Q1j
a bond
H
a bond
NH
O
a bond
Q3e
OH


3665
CH
S
Q1i
a bond
Me
a bond
NH
S
NH
Q3e
OH


3666
CH
S
Q1i
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3667
CH
S
Q1i
a bond
Me
a bond
NH
O
NH
Q3e
OH


3668
CH
S
Q1i
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3669
CH
S
Q1i
a bond
H
a bond
NH
S
NH
Q3e
OH


3670
CH
S
Q1i
a bond
H
a bond
NH
S
a bond
Q3e
OH


3671
CH
S
Q1i
a bond
H
a bond
NH
O
NH
Q3e
OH


3672
CH
S
Q1i
a bond
H
a bond
NH
O
a bond
Q3e
OH


3673
CH
S
Q1j
a bond
Me
a bond
NH
S
NH
Q3e
OH


3674
CH
S
Q1j
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3675
CH
S
Q1j
a bond
Me
a bond
NH
O
NH
Q3e
OH


3676
CH
S
Q1j
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3677
CH
S
Q1j
a bond
H
a bond
NH
S
NH
Q3e
OH


3678
CH
S
Q1j
a bond
H
a bond
NH
S
a bond
Q3e
OH


3679
CH
S
Q1j
a bond
H
a bond
NH
O
NH
Q3e
OH


3680
CH
S
Q1j
a bond
H
a bond
NH
O
a bond
Q3e
OH


3681
CH
O
Q1i
a bond
Me
a bond
NH
S
NH
Q3e
OH


3682
CH
O
Q1i
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3683
CH
O
Q1i
a bond
Me
a bond
NH
O
NH
Q3e
OH


3684
CH
O
Q1i
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3685
CH
O
Q1i
a bond
H
a bond
NH
S
NH
Q3e
OH


3686
CH
O
Q1i
a bond
H
a bond
NH
S
a bond
Q3e
OH


3687
CH
O
Q1i
a bond
H
a bond
NH
O
NH
Q3e
OH


3688
CH
O
Q1i
a bond
H
a bond
NH
O
a bond
Q3e
OH


3689
CH
O
Q1j
a bond
Me
a bond
NH
S
NH
Q3e
OH


3690
CH
O
Q1j
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3691
CH
O
Q1j
a bond
Me
a bond
NH
O
NH
Q3e
OH


3692
CH
O
Q1j
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3693
CH
O
Q1j
a bond
H
a bond
NH
S
NH
Q3e
OH


3694
CH
O
Q1j
a bond
H
a bond
NH
S
a bond
Q3e
OH


3695
CH
O
Q1j
a bond
H
a bond
NH
O
NH
Q3e
OH


3696
CH
O
Q1j
a bond
H
a bond
NH
O
a bond
Q3e
OH


3697
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
NH
Q3e
OH


3698
CMe
NMe
Q1i
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3699
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
NH
Q3e
OH


3700
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3701
CMe
NMe
Q1i
a bond
H
a bond
NH
S
NH
Q3e
OH


3702
CMe
NMe
Q1i
a bond
H
a bond
NH
S
a bond
Q3e
OH


3703
CMe
NMe
Q1i
a bond
H
a bond
NH
O
NH
Q3e
OH


3704
CMe
NMe
Q1i
a bond
H
a bond
NH
O
a bond
Q3e
OH


3705
CMe
NMe
Q1j
a bond
Me
a bond
NH
S
NH
Q3e
OH


3706
CMe
NMe
Q1j
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3707
CMe
NMe
Q1j
a bond
Me
a bond
NH
O
NH
Q3e
OH


3708
CMe
NMe
Q1i
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3709
CMe
NMe
Q1i
a bond
H
a bond
NH
S
NH
Q3e
OH


3710
CMe
NMe
Q1j
a bond
H
a bond
NH
S
a bond
Q3e
OH


3711
CMe
NMe
Q1j
a bond
H
a bond
NH
O
NH
Q3e
OH


3712
CMe
NMe
Q1j
a bond
H
a bond
NH
O
a bond
Q3e
OH


3713
CMe
S
Q1i
a bond
Me
a bond
NH
S
NH
Q3e
OH


3714
CMe
S
Q1i
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3715
CMe
S
Q1i
a bond
Me
a bond
NH
O
NH
Q3e
OH


3716
CMe
S
Q1i
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3717
CMe
S
Q1i
a bond
H
a bond
NH
S
NH
Q3e
OH


3718
CMe
S
Q1i
a bond
H
a bond
NH
S
a bond
Q3e
OH


3719
CMe
S
Q1i
a bond
H
a bond
NH
O
NH
Q3e
OH


3720
CMe
S
Q1i
a bond
H
a bond
NH
O
a bond
Q3e
OH


3721
CMe
S
Q1j
a bond
Me
a bond
NH
S
NH
Q3e
OH


3722
CMe
S
Q1j
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3723
CMe
S
Q1j
a bond
Me
a bond
NH
O
NH
Q3e
OH


3724
CMe
S
Q1j
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3725
CMe
S
Q1j
a bond
H
a bond
NH
S
NH
Q3e
OH


3726
CMe
S
Q1j
a bond
H
a bond
NH
S
a bond
Q3e
OH


3727
CMe
S
Q1j
a bond
H
a bond
NH
O
NH
Q3e
OH


3728
CMe
S
Q1j
a bond
H
a bond
NH
O
a bond
Q3e
OH


3729
CMe
O
Q1j
a bond
Me
a bond
NH
S
NH
Q3e
OH


3730
CMe
O
Q1j
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3731
CMe
O
Q1i
a bond
Me
a bond
NH
O
NH
Q3e
OH


3732
CMe
O
Q1i
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3733
CMe
O
Q1i
a bond
H
a bond
NH
S
NH
Q3e
OH


3734
CMe
O
Q1i
a bond
H
a bond
NH
S
a bond
Q3e
OH


3735
CMe
O
Q1i
a bond
H
a bond
NH
O
NH
Q3e
OH


3736
CMe
O
Q1i
a bond
H
a bond
NH
O
a bond
Q3e
OH


3737
CMe
O
Q1j
a bond
Me
a bond
NH
S
NH
Q3e
OH


3738
CMe
O
Q1j
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3739
CMe
O
Q1j
a bond
Me
a bond
NH
O
NH
Q3e
OH


3740
CMe
O
Q1j
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3741
CMe
O
Q1j
a bond
H
a bond
NH
S
NH
Q3e
OH


3742
CMe
O
Q1j
a bond
H
a bond
NH
S
a bond
Q3e
OH


3743
CMe
O
Q1j
a bond
H
a bond
NH
O
NH
Q3e
OH


3744
CMe
O
Q1j
a bond
H
a bond
NH
O
a bond
Q3e
OH


3745
N
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
Q3a
OH


3746
N
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
Q3e
OH


3747
N
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3a
OH


3748
N
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3b
OH


3749
N
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3c
OH


3750
N
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3d
OH


3751
N
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3e
OH


3752
N
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3f
OH


3753
N
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3g
OH


3754
N
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3h
OH


3755
N
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3i
OH


3756
N
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3j
OH


3757
N
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3758
N
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3759
N
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3a
OH


3760
N
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3b
OH


3761
N
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3c
OH


3762
N
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3d
OH


3763
N
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3e
OH


3764
N
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3f
OH


3765
N
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3g
OH


3766
N
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3h
OH


3767
N
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3i
OH


3768
N
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3j
OH


3769
N
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
Q3a
OH


3770
N
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
Q3e
OH


3771
N
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3a
OH


3772
N
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3b
OH


3773
N
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3c
OH


3774
N
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3d
OH


3775
N
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3e
OH


3776
N
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3f
OH


3777
N
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3g
OH


3778
N
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3h
OH


3779
N
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3i
OH


3780
N
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3j
OH


3781
N
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3782
N
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3783
N
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3a
OH


3784
N
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3b
OH


3785
N
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3c
OH


3786
N
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3d
OH


3787
N
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3e
OH


3788
N
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3f
OH


3789
N
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3g
OH


3790
N
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3h
OH


3791
N
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3i
OH


3792
N
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3j
OH


3793
N
NMe
Q1o′
a bond
H
a bond
NH
S
NH
Q3a
OH


3794
N
NMe
Q1o′
a bond
H
a bond
NH
S
NH
Q3e
OH


3795
N
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3a
OH


3796
N
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3b
OH


3797
N
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3c
OH


3798
N
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3d
OH


3799
N
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3e
OH


3800
N
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3f
OH


3801
N
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3g
OH


3802
N
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3h
OH


3803
N
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3i
OH


3804
N
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3j
OH


3805
N
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
Q3a
OH


3806
N
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
Q3e
OH


3807
N
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3a
OH


3808
N
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3b
OH


3809
N
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3c
OH


3810
N
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3d
OH


3811
N
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3e
OH


3812
N
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3f
OH


3813
N
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3g
OH


3814
N
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3h
OH


3815
N
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3i
OH


3816
N
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3j
OH


3817
N
NMe
Q1o′
a bond
H
a bond
NH
O
NH
Q3a
OH


3818
N
NNe
Q1o′
a bond
H
a bond
NH
O
NH
Q3e
OH


3819
N
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3a
OH


3820
N
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3b
OH


3821
N
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3c
OH


3822
N
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3d
OH


3823
N
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3e
OH


3824
N
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3f
OH


3825
N
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3g
OH


3826
N
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3h
OH


3827
N
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3i
OH


3828
N
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3j
OH


3829
N
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
Q3a
OH


3830
N
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
Q3e
OH


3831
N
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3a
OH


3832
N
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3b
OH


3833
N
NMe
Q1a′
a bond
H
a bond
NH
O
a bond
T3c
OH


3834
N
NMe
Q1a′
a bond
H
a bond
NH
O
a bond
T3d
OH


3835
N
NMe
Q1a′
a bond
H
a bond
NH
O
a bond
T3e
OH


3836
N
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3f
OH


3837
N
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3g
OH


3838
N
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3h
OH


3839
N
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3i
OH


3840
N
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3j
OH


3841
N
S
Q1a′
a bond
Me
a bond
NH
S
NH
Q3a
OH


3842
N
S
Q1o′
a bond
Me
a bond
NH
S
NH
Q3e
OH


3843
N
S
Q1a′
a bond
Me
a bond
NH
S
NH
T3a
OH


3844
N
S
Q1a′
a bond
Me
a bond
NH
S
NH
T3b
OH


3845
N
S
Q1o′
a bond
Me
a bond
NH
S
NH
T3c
OH


3846
N
S
Q1a′
a bond
Me
a bond
NH
S
NH
T3d
OH


3847
N
S
Q1o′
a bond
Me
a bond
NH
S
NH
T3e
OH


3848
N
S
Q1a′
a bond
Me
a bond
NH
S
NH
T3f
OH


3849
N
S
Q1a′
a bond
Me
a bond
NH
S
NH
T3g
OH


3850
N
S
Q1o′
a bond
Me
a bond
NH
S
NH
T3h
OH


3851
N
S
Q1o′
a bond
Me
a bond
NH
S
NH
T3i
OH


3852
N
S
Q1o′
a bond
Me
a bond
NH
S
NH
T3j
OH


3853
N
S
Q1o′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3854
N
S
Q1o′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3855
N
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3a
OH


3856
N
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3b
OH


3857
N
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3c
OH


3858
N
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3d
OH


3859
N
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3e
OH


3860
N
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3f
OH


3861
N
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3g
OH


3862
N
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3h
OH


3863
N
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3i
OH


3864
N
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3j
OH


3865
N
S
Q1o′
a bond
Me
a bond
NH
O
NH
Q3a
OH


3866
N
S
Q1o′
a bond
Me
a bond
NH
O
NH
Q3e
OH


3867
N
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3a
OH


3868
N
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3b
OH


3869
N
S
Q1a′
a bond
Me
a bond
NH
O
NH
T3c
OH


3870
N
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3d
OH


3871
N
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3e
OH


3872
N
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3f
OH


3873
N
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3g
OH


3874
N
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3h
OH


3875
N
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3i
OH


3876
N
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3j
OH


3877
N
S
Q1o′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3878
N
S
Q1o′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3879
N
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3a
OH


3880
N
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3b
OH


3881
N
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3c
OH


3882
N
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3d
OH


3883
N
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3e
OH


3884
N
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3f
OH


3885
N
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3g
OH


3886
N
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3h
OH


3887
N
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3i
OH


3888
N
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3j
OH


3889
N
S
Q1o′
a bond
H
a bond
NH
S
NH
Q3a
OH


3890
N
S
Q1o′
a bond
H
a bond
NH
S
NH
Q3e
OH


3891
N
S
Q1o′
a bond
H
a bond
NH
S
NH
T3a
OH


3892
N
S
Q1o′
a bond
H
a bond
NH
S
NH
T3b
OH


3893
N
S
Q1o′
a bond
H
a bond
NH
S
NH
T3c
OH


3894
N
S
Q1o′
a bond
H
a bond
NH
S
NH
T3d
OH


3895
N
S
Q1o′
a bond
H
a bond
NH
S
NH
T3e
OH


3896
N
S
Q1o′
a bond
H
a bond
NH
S
NH
T3f
OH


3897
N
S
Q1o′
a bond
H
a bond
NH
S
NH
T3g
OH


3898
N
S
Q1o′
a bond
H
a bond
NH
S
NH
T3h
OH


3899
N
S
Q1o′
a bond
H
a bond
NH
S
NH
T3i
OH


3900
N
S
Q1o′
a bond
H
a bond
NH
S
NH
T3j
OH


3901
N
S
Q1o′
a bond
H
a bond
NH
S
a bond
Q3a
OH


3902
N
S
Q1o′
a bond
H
a bond
NH
S
a bond
Q3e
OH


3903
N
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3a
OH


3904
N
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3b
OH


3905
N
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3c
OH


3906
N
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3d
OH


3907
N
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3e
OH


3908
N
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3f
OH


3909
N
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3g
OH


3910
N
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3h
OH


3911
N
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3i
OH


3912
N
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3j
OH


3913
N
S
Q1o′
a bond
H
a bond
NH
O
NH
Q3a
OH


3914
N
S
Q1o′
a bond
H
a bond
NH
O
NH
Q3e
OH


3915
N
S
Q1o′
a bond
H
a bond
NH
O
NH
T3a
OH


3916
N
S
Q1o′
a bond
H
a bond
NH
O
NH
T3b
OH


3917
N
S
Q1o′
a bond
H
a bond
NH
O
NH
T3c
OH


3918
N
S
Q1o′
a bond
H
a bond
NH
O
NH
T3d
OH


3919
N
S
Q1o′
a bond
H
a bond
NH
O
NH
T3e
OH


3920
N
S
Q1o′
a bond
H
a bond
NH
O
NH
T3f
OH


3921
N
S
Q1o′
a bond
H
a bond
NH
O
NH
T3g
OH


3922
N
S
Q1o′
a bond
H
a bond
NH
O
NH
T3h
OH


3923
N
S
Q1o′
a bond
H
a bond
NH
O
NH
T3i
OH


3924
N
S
Q1o′
a bond
H
a bond
NH
O
NH
T3j
OH


3925
N
S
Q1o′
a bond
H
a bond
NH
O
a bond
Q3a
OH


3926
N
S
Q1o′
a bond
H
a bond
NH
O
a bond
Q3e
OH


3927
N
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3a
OH


3928
N
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3b
OH


3929
N
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3c
OH


3930
N
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3d
OH


3931
N
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3e
OH


3932
N
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3f
OH


3933
N
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3g
OH


3934
N
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3h
OH


3935
N
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3i
OH


3936
N
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3j
OH


3937
N
O
Q1o′
a bond
Me
a bond
NH
S
NH
Q3a
OH


3938
N
O
Q1o′
a bond
Me
a bond
NH
S
NH
Q3e
OH


3939
N
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3a
OH


3940
N
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3b
OH


3941
N
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3c
OH


3942
N
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3d
OH


3943
N
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3e
OH


3944
N
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3f
OH


3945
N
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3g
OH


3946
N
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3h
OH


3947
N
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3i
OH


3948
N
O
Q1o′
a bond
Me
a bond
NH
S
NH
T31
OH


3949
N
O
Q1o′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


3950
N
O
Q1o′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


3951
N
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3a
OH


3952
N
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3b
OH


3953
N
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3c
OH


3954
N
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3d
OH


3955
N
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3e
OH


3956
N
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3f
OH


3957
N
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3g
OH


3958
N
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3h
OH


3959
N
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3i
OH


3960
N
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3j
OH


3961
N
O
Q1o′
a bond
Me
a bond
NH
O
NH
Q3a
OH


3962
N
O
Q1o′
a bond
Me
a bond
NH
O
NH
Q3e
OH


3963
N
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3a
OH


3964
N
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3b
OH


3965
N
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3c
OH


3966
N
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3d
OH


3967
N
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3e
OH


3968
N
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3f
OH


3969
N
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3g
OH


3970
N
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3h
OH


3971
N
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3i
OH


3972
N
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3j
OH


3973
N
O
Q1o′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


3974
N
O
Q1a′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


3975
N
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3a
OH


3976
N
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3b
OH


3977
N
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3c
OH


3978
N
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3d
OH


3979
N
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3e
OH


3980
N
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3f
OH


3981
N
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3g
OH


3982
N
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3h
OH


3983
N
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3i
OH


3984
N
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3j
OH


3985
N
O
Q1o′
a bond
H
a bond
NH
S
NH
Q3a
OH


3986
N
O
Q1o′
a bond
H
a bond
NH
S
NH
Q3e
OH


3987
N
O
Q1o′
a bond
H
a bond
NH
S
NH
T3a
OH


3988
N
O
Q1o′
a bond
H
a bond
NH
S
NH
T3b
OH


3989
N
O
Q1o′
a bond
H
a bond
NH
S
NH
T3c
OH


3990
N
O
Q1o′
a bond
H
a bond
NH
S
NH
T3d
OH


3991
N
O
Q1o′
a bond
H
a bond
NH
S
NH
T3e
OH


3992
N
O
Q1o′
a bond
H
a bond
NH
S
NH
T3f
OH


3993
N
O
Q1o′
a bond
H
a bond
NH
S
NH
T3g
OH


3994
N
O
Q1o′
a bond
H
a bond
NH
S
NH
T3h
OH


3995
N
O
Q1o′
a bond
H
a bond
NH
S
NH
T3i
OH


3996
N
O
Q1o′
a bond
H
a bond
NH
S
NH
T3j
OH


3997
N
O
Q1o′
a bond
H
a bond
NH
S
a bond
Q3a
OH


3998
N
O
Q1o′
a bond
H
a bond
NH
S
a bond
Q3e
OH


3999
N
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3a
OH


4000
N
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3b
OH


4001
N
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3c
OH


4002
N
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3d
OH


4003
N
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3e
OH


4004
N
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3f
OH


4005
N
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3g
OH


4006
N
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3h
OH


4007
N
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3i
OH


4008
N
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3j
OH


4009
N
O
Q1o′
a bond
H
a bond
NH
O
NH
Q3a
OH


4010
N
O
Q1o′
a bond
H
a bond
NH
O
NH
Q3e
OH


4011
N
O
Q1o′
a bond
H
a bond
NH
O
NH
T3a
OH


4012
N
O
Q1o′
a bond
H
a bond
NH
O
NH
T3b
OH


4013
N
O
Q1o′
a bond
H
a bond
NH
O
NH
T3c
OH


4014
N
O
Q1o′
a bond
H
a bond
NH
O
NH
T3d
OH


4015
N
O
Q1o′
a bond
H
a bond
NH
O
NH
T3e
OH


4016
N
O
Q1o′
a bond
H
a bond
NH
O
NH
T3f
OH


4017
N
O
Q1o′
a bond
H
a bond
NH
O
NH
T3g
OH


4018
N
O
Q1o′
a bond
H
a bond
NH
O
NH
T3h
OH


4019
N
O
Q1o′
a bond
H
a bond
NH
O
NH
T3i
OH


4020
N
O
Q1o′
a bond
H
a bond
NH
O
NH
T3j
OH


4021
N
O
Q1o′
a bond
H
a bond
NH
O
a bond
Q3a
OH


4022
N
O
Q1o′
a bond
H
a bond
NH
O
a bond
Q3e
OH


4023
N
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3a
OH


4024
N
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3b
OH


4025
N
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3c
OH


4026
N
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3d
OH


4027
N
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3e
OH


4028
N
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3f
OH


4029
N
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3g
OH


4030
N
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3h
OH


4031
N
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3i
OH


4032
N
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3j
OH


4033
CH
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4034
CH
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4035
CH
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3a
OH


4036
CH
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3b
OH


4037
CH
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3c
OH


4038
CH
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3d
OH


4039
CH
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3e
OH


4040
CH
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3f
OH


4041
CH
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3g
OH


4042
CH
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3h
OH


4043
CH
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3i
OH


4044
CH
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3j
OH


4045
CH
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4046
CH
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4047
CH
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3a
OH


4048
CH
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3b
OH


4049
CH
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3c
OH


4050
CH
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3d
OH


4051
CH
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3e
OH


4052
CH
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3f
OH


4053
CH
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3g
OH


4054
CH
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3h
OH


4055
CH
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3i
OH


4056
CH
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3j
OH


4057
CH
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4058
CH
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4059
CH
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3a
OH


4060
CH
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3b
OH


4061
CH
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3c
OH


4062
CH
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3d
OH


4063
CH
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3e
OH


4064
CH
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3f
OH


4065
CH
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3g
OH


4066
CH
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3h
OH


4067
CH
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3i
OH


4068
CH
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3j
OH


4069
CH
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4070
CH
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4071
CH
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3a
OH


4072
CH
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3b
OH


4073
CH
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3c
OH


4074
CH
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3d
OH


4075
CH
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3e
OH


4076
CH
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3f
OH


4077
CH
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3g
OH


4078
CH
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3h
OH


4079
CH
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3i
OH


4080
CH
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3j
OH


4081
CH
NMe
Q1o′
a bond
H
a bond
NH
S
NH
Q3a
OH


4082
CH
NMe
Q1o′
a bond
H
a bond
NH
S
NH
Q3e
OH


4083
CH
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3a
OH


4084
CH
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3b
OH


4085
CH
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3c
OH


4086
CH
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3d
OH


4087
CH
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3e
OH


4088
CH
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3f
OH


4089
CH
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3g
OH


4090
CH
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3h
OH


4091
CH
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3i
OH


4092
CH
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3j
OH


4093
CH
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
Q3a
OH


4094
CH
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
Q3e
OH


4095
CH
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3a
OH


4096
CH
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3b
OH


4097
CH
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3c
OH


4098
CH
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3d
OH


4099
CH
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3e
OH


4100
CH
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3f
OH


4101
CH
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3g
OH


4102
CH
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3h
OH


4103
CH
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3i
OH


4104
CH
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3j
OH


4105
CH
NMe
Q1o′
a bond
H
a bond
NH
O
NH
Q3a
OH


4106
CH
NMe
Q1o′
a bond
H
a bond
NH
O
NH
Q3e
OH


4107
CH
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3a
OH


4108
CH
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3b
OH


4109
CH
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3c
OH


4110
CH
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3d
OH


4111
CH
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3e
OH


4112
CH
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3f
OH


4113
CH
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3g
OH


4114
CH
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3h
OH


4115
CH
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3i
OH


4116
CH
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3j
OH


4117
CH
NNe
Q1o′
a bond
H
a bond
NH
O
a bond
Q3a
OH


4118
CH
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
Q3e
OH


4119
CH
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3a
OH


4120
CH
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3b
OH


4121
CH
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3c
OH


4122
CH
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3d
OH


4123
CH
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3e
OH


4124
CH
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3f
OH


4125
CH
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3g
OH


4126
CH
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3h
OH


4127
CH
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3i
OH


4128
CH
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3j
OH


4129
CH
S
Q1o′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4130
CH
S
Q1o′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4131
CH
S
Q1o′
a bond
Me
a bond
NH
S
NH
T3a
OH


4132
CH
S
Q1o′
a bond
Me
a bond
NH
S
NH
T3b
OH


4133
CH
S
Q1o′
a bond
Me
a bond
NH
S
NH
T3c
OH


4134
CH
S
Q1o′
a bond
Me
a bond
NH
S
NH
T3d
OH


4135
CH
S
Q1o′
a bond
Me
a bond
NH
S
NH
T3e
OH


4136
CH
S
Q1o′
a bond
Me
a bond
NH
S
NH
T3f
OH


4137
CH
S
Q1o′
a bond
Me
a bond
NH
S
NH
T3g
OH


4138
CH
S
Q1o′
a bond
Me
a bond
NH
S
NH
T3h
OH


4139
CH
S
Q1o′
a bond
Me
a bond
NH
S
NH
T3i
OH


4140
CH
S
Q1o′
a bond
Me
a bond
NH
S
NH
T3j
OH


4141
CH
S
Q1o′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4142
CH
S
Q1o′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4143
CH
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3a
OH


4144
CH
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3b
OH


4145
CH
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3c
OH


4146
CH
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3d
OH


4147
CH
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3e
OH


4148
CH
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3f
OH


4149
CH
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3g
OH


4150
CH
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3h
OH


4151
CH
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3i
OH


4152
CH
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3j
OH


4153
CH
S
Q1o′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4154
CH
S
Q1o′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4155
CH
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3a
OH


4156
CH
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3b
OH


4157
CH
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3c
OH


4158
CH
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3d
OH


4159
CH
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3e
OH


4160
CH
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3f
OH


4161
CH
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3g
OH


4162
CH
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3h
OH


4163
CH
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3i
OH


4164
CH
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3j
OH


4165
CH
S
Q1o′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4166
CH
S
Q1o′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4167
CH
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3a
OH


4168
CH
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3b
OH


4169
CH
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3c
OH


4170
CH
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3d
OH


4171
CH
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3e
OH


4172
CH
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3f
OH


4173
CH
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3g
OH


4174
CH
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3h
OH


4175
CH
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3i
OH


4176
CH
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3j
OH


4177
CH
S
Q1o′
a bond
H
a bond
NH
S
NH
Q3a
OH


4178
CH
S
Q1o′
a bond
H
a bond
NH
S
NH
Q3e
OH


4179
CH
S
Q1o′
a bond
H
a bond
NH
S
NH
T3a
OH


4180
CH
S
Q1o′
a bond
H
a bond
NH
S
NH
T3b
OH


4181
CH
S
Q1o′
a bond
H
a bond
NH
S
NH
T3c
OH


4182
CH
S
Q1o′
a bond
H
a bond
NH
S
NH
T3d
OH


4183
CH
S
Q1o′
a bond
H
a bond
NH
S
NH
T3e
OH


4184
CH
S
Q1o′
a bond
H
a bond
NH
S
NH
T3f
OH


4185
CH
S
Q1o′
a bond
H
a bond
NH
S
NH
T3g
OH


4186
CH
S
Q1o′
a bond
H
a bond
NH
S
NH
T3h
OH


4187
CH
S
Q1o′
a bond
H
a bond
NH
S
NH
T3i
OH


4188
CH
S
Q1o′
a bond
H
a bond
NH
S
NH
T3j
OH


4189
CH
S
Q1o′
a bond
H
a bond
NH
S
a bond
Q3a
OH


4190
CH
S
Q1o′
a bond
H
a bond
NH
S
a bond
Q3e
OH


4191
CH
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3a
OH


4192
CH
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3b
OH


4193
CH
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3c
OH


4194
CH
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3d
OH


4195
CH
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3e
OH


4196
CH
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3f
OH


4197
CH
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3g
OH


4198
CH
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3h
OH


4199
CH
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3i
OH


4200
CH
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3j
OH


4201
CH
S
Q1o′
a bond
H
a bond
NH
O
NH
Q3a
OH


4202
CH
S
Q1o′
a bond
H
a bond
NH
O
NH
Q3e
OH


4203
CH
S
Q1o′
a bond
H
a bond
NH
O
NH
T3a
OH


4204
CH
S
Q1o′
a bond
H
a bond
NH
O
NH
T3b
OH


4205
CH
S
Q1o′
a bond
H
a bond
NH
O
NH
T3c
OH


4206
CH
S
Q1o′
a bond
H
a bond
NH
O
NH
T3d
OH


4207
CH
S
Q1o′
a bond
H
a bond
NH
O
NH
T3e
OH


4208
CH
S
Q1o′
a bond
H
a bond
NH
O
NH
T3f
OH


4209
CH
S
Q1o′
a bond
H
a bond
NH
O
NH
T3g
OH


4210
CH
S
Q1o′
a bond
H
a bond
NH
O
NH
T3h
OH


4211
CH
S
Q1o′
a bond
H
a bond
NH
O
NH
T3i
OH


4212
CH
S
Q1o′
a bond
H
a bond
NH
O
NH
T3j
OH


4213
CH
S
Q1o′
a bond
H
a bond
NH
O
a bond
Q3a
OH


4214
CH
S
Q1o′
a bond
H
a bond
NH
O
a bond
Q3e
OH


4215
CH
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3a
OH


4216
CH
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3b
OH


4217
CH
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3c
OH


4218
CH
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3d
OH


4219
CH
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3e
OH


4220
CH
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3f
OH


4221
CH
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3g
OH


4222
CH
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3h
OH


4223
CH
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3i
OH


4224
CH
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3j
OH


4225
CH
O
Q1o′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4226
CH
O
Q1o′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4227
CH
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3a
OH


4228
CH
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3b
OH


4229
CH
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3c
OH


4230
CH
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3d
OH


4231
CH
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3e
OH


4232
CH
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3f
OH


4233
CH
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3g
OH


4234
CH
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3h
OH


4235
CH
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3i
OH


4236
CH
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3j
OH


4237
CH
O
Q1o′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4238
CH
O
Q1o′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4239
CH
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3a
OH


4240
CH
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3b
OH


4241
CH
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3c
OH


4242
CH
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3d
OH


4243
CH
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3e
OH


4244
CH
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3f
OH


4245
CH
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3g
OH


4246
CH
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3h
OH


4247
CH
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3i
OH


4248
CH
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3j
OH


4249
CH
O
Q1o′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4250
CH
O
Q1o′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4251
CH
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3a
OH


4252
CH
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3b
OH


4253
CH
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3c
OH


4254
CH
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3d
OH


4255
CH
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3e
OH


4256
CH
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3f
OH


4257
CH
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3g
OH


4258
CH
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3h
OH


4259
CH
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3i
OH


4260
CH
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3j
OH


4261
CH
O
Q1o′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4262
CH
O
Q1o′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4263
CH
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3a
OH


4264
CH
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3b
OH


4265
CH
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3c
OH


4266
CH
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3d
OH


4267
CH
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3e
OH


4268
CH
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3f
OH


4269
CH
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3g
OH


4270
CH
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3h
OH


4271
CH
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3i
OH


4272
CH
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3j
OH


4273
CH
O
Q1o′
a bond
H
a bond
NH
S
NH
Q3a
OH


4274
CH
O
Q1o′
a bond
H
a bond
NH
S
NH
Q3e
OH


4275
CH
O
Q1o′
a bond
H
a bond
NH
S
NH
T3a
OH


4276
CH
O
Q1o′
a bond
H
a bond
NH
S
NH
T3b
OH


4277
CH
O
Q1o′
a bond
H
a bond
NH
S
NH
T3c
OH


4278
CH
O
Q1o′
a bond
H
a bond
NH
S
NH
T3d
OH


4279
CH
O
Q1o′
a bond
H
a bond
NH
S
NH
T3e
OH


4280
CH
O
Q1o′
a bond
H
a bond
NH
S
NH
T3f
OH


4281
CH
O
Q1o′
a bond
H
a bond
NH
S
NH
T3g
OH


4282
CH
O
Q1o′
a bond
H
a bond
NH
S
NH
T3h
OH


4283
CH
O
Q1o′
a bond
H
a bond
NH
S
NH
T3i
OH


4284
CH
O
Q1o′
a bond
H
a bond
NH
S
NH
T3j
OH


4285
CH
O
Q1o′
a bond
H
a bond
NH
S
a bond
Q3a
OH


4286
CH
O
Q1o′
a bond
H
a bond
NH
S
a bond
Q3e
OH


4287
CH
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3a
OH


4288
CH
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3b
OH


4289
CH
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3c
OH


4290
CH
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3d
OH


4291
CH
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3e
OH


4292
CH
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3f
OH


4293
CH
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3g
OH


4294
CH
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3h
OH


4295
CH
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3i
OH


4296
CH
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3j
OH


4297
CH
O
Q1o′
a bond
H
a bond
NH
O
NH
Q3a
OH


4298
CH
O
Q1o′
a bond
H
a bond
NH
O
NH
Q3e
OH


4299
CH
O
Q1o′
a bond
H
a bond
NH
O
NH
T3a
OH


4300
CH
O
Q1o′
a bond
H
a bond
NH
O
NH
T3b
OH


4301
CH
O
Q1o′
a bond
H
a bond
NH
O
NH
T3c
OH


4302
CH
O
Q1o′
a bond
H
a bond
NH
O
NH
T3d
OH


4303
CH
O
Q1o′
a bond
H
a bond
NH
O
NH
T3e
OH


4304
CH
O
Q1o′
a bond
H
a bond
NH
O
NH
T3f
OH


4305
CH
O
Q1o′
a bond
H
a bond
NH
O
NH
T3g
OH


4306
CH
O
Q1o′
a bond
H
a bond
NH
O
NH
T3h
OH


4307
CH
O
Q1a′
a bond
H
a bond
NH
O
NH
T3i
OH


4308
CH
O
Q1o′
a bond
H
a bond
NH
O
NH
T3j
OH


4309
CH
O
Q1o′
a bond
H
a bond
NH
O
a bond
Q3a
OH


4310
CH
O
Q1a′
a bond
H
a bond
NH
O
a bond
Q3e
OH


4311
CH
O
Q1a′
a bond
H
a bond
NH
O
a bond
T3a
OH


4312
CH
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3b
OH


4313
CH
O
Q1a′
a bond
H
a bond
NH
O
a bond
T3c
OH


4314
CH
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3d
OH


4315
CH
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3e
OH


4316
CH
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3f
OH


4317
CH
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3g
OH


4318
CH
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3h
OH


4319
CH
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3i
OH


4320
CH
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3j
OH


4321
CMe
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4322
CMe
NMe
Q1a′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4323
CMe
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3a
OH


4324
CMe
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3b
OH


4325
CMe
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3c
OH


4326
CMe
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3d
OH


4327
CMe
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3e
OH


4328
CMe
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3f
OH


4329
CMe
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3g
OH


4330
CMe
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3h
OH


4331
CMe
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3i
OH


4332
CMe
NMe
Q1o′
a bond
Me
a bond
NH
S
NH
T3j
OH


4333
CMe
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4334
CMe
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4335
CMe
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3a
OH


4336
CMe
NMe
Q1a′
a bond
Me
a bond
NH
S
a bond
T3b
OH


4337
CMe
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3c
OH


4338
CMe
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3d
OH


4339
CMe
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3e
OH


4340
CMe
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3f
OH


4341
CMe
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3g
OH


4342
CMe
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3h
OH


4343
CMe
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3i
OH


4344
CMe
NMe
Q1o′
a bond
Me
a bond
NH
S
a bond
T3j
OH


4345
CMe
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4346
CMe
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4347
CMe
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3a
OH


4348
CMe
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3b
OH


4349
CMe
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3c
OH


4350
CMe
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3d
OH


4351
CMe
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3e
OH


4352
CMe
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3f
OH


4353
CMe
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3g
OH


4354
CMe
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3h
OH


4355
CMe
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3i
OH


4356
CMe
NMe
Q1o′
a bond
Me
a bond
NH
O
NH
T3j
OH


4357
CMe
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4358
CMe
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4359
CMe
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3a
OH


4360
CMe
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3b
OH


4361
CMe
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3c
OH


4362
CMe
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3d
OH


4363
CMe
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3e
OH


4364
CMe
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3f
OH


4365
CMe
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3g
OH


4366
CMe
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3h
OH


4367
CMe
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T3i
OH


4368
CMe
NMe
Q1o′
a bond
Me
a bond
NH
O
a bond
T31
OH


4369
CMe
NMe
Q1o′
a bond
H
a bond
NH
S
NH
Q3a
OH


4370
CMe
NMe
Q1o′
a bond
H
a bond
NH
S
NH
Q3e
OH


4371
CMe
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3a
OH


4372
CMe
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3b
OH


4373
CMe
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3c
OH


4374
CMe
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3d
OH


4375
CMe
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3e
OH


4376
CMe
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3f
OH


4377
CMe
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3g
OH


4378
CMe
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3h
OH


4379
CMe
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3i
OH


4380
CMe
NMe
Q1o′
a bond
H
a bond
NH
S
NH
T3j
OH


4381
CMe
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
Q3a
OH


4382
CMe
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
Q3e
OH


4383
CMe
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3a
OH


4384
CMe
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3b
OH


4385
CMe
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3c
OH


4386
CMe
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3d
OH


4387
CMe
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3e
OH


4388
CMe
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3f
OH


4389
CMe
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3g
OH


4390
CMe
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3h
OH


4391
CMe
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3i
OH


4392
CMe
NMe
Q1o′
a bond
H
a bond
NH
S
a bond
T3j
OH


4393
CMe
NMe
Q1o′
a bond
H
a bond
NH
O
NH
Q3a
OH


4394
CMe
NMe
Q1o′
a bond
H
a bond
NH
O
NH
Q3e
OH


4395
CMe
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3a
OH


4396
CMe
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3b
OH


4397
CMe
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3c
OH


4398
CMe
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3d
OH


4399
CMe
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3e
OH


4400
CMe
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3f
OH


4401
CMe
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3g
OH


4402
CMe
NNe
Q1o′
a bond
H
a bond
NH
O
NH
T3h
OH


4403
CMe
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3i
OH


4404
CMe
NMe
Q1o′
a bond
H
a bond
NH
O
NH
T3j
OH


4405
CMe
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
Q3a
OH


4406
CMe
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
Q3e
OH


4407
CMe
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3a
OH


4408
CMe
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3b
OH


4409
CMe
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3c
OH


4410
CMe
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3d
OH


4411
CMe
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3e
OH


4412
CMe
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3f
OH


4413
CMe
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3g
OH


4414
CMe
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3h
OH


4415
CMe
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3i
OH


4416
CMe
NMe
Q1o′
a bond
H
a bond
NH
O
a bond
T3j
OH


4417
CMe
S
Q1o′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4418
CMe
S
Q1o′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4419
CMe
S
Q1o′
a bond
Me
a bond
NH
S
NH
T3a
OH


4420
CMe
S
Q1o′
a bond
Me
a bond
NH
S
NH
T3b
OH


4421
CMe
S
Q1o′
a bond
Me
a bond
NH
S
NH
T3c
OH


4422
CMe
S
Q1o′
a bond
Me
a bond
NH
S
NH
T3d
OH


4423
CMe
S
Q1o′
a bond
Me
a bond
NH
S
NH
T3e
OH


4424
CMe
S
Q1o′
a bond
Me
a bond
NH
S
NH
T3f
OH


4425
CMe
S
Q1o′
a bond
Me
a bond
NH
S
NH
T3g
OH


4426
CMe
S
Q1o′
a bond
Me
a bond
NH
S
NH
T3h
OH


4427
CMe
S
Q1o′
a bond
Me
a bond
NH
S
NH
T3i
OH


4428
CMe
S
Q1o′
a bond
Me
a bond
NH
S
NH
T3j
OH


4429
CMe
S
Q1o′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4430
CMe
S
Q1o′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4431
CMe
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3a
OH


4432
CMe
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3b
OH


4433
CMe
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3c
OH


4434
CMe
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3d
OH


4435
CMe
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3e
OH


4436
CMe
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3f
OH


4437
CMe
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3g
OH


4438
CMe
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3h
OH


4439
CMe
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3i
OH


4440
CMe
S
Q1o′
a bond
Me
a bond
NH
S
a bond
T3j
OH


4441
CMe
S
Q1o′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4442
CMe
S
Q1o′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4443
CMe
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3a
OH


4444
CMe
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3b
OH


4445
CMe
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3c
OH


4446
CMe
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3d
OH


4447
CMe
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3e
OH


4448
CMe
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3f
OH


4449
CMe
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3g
OH


4450
CMe
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3h
OH


4451
CMe
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3i
OH


4452
CMe
S
Q1o′
a bond
Me
a bond
NH
O
NH
T3j
OH


4453
CMe
S
Q1o′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4454
CMe
S
Q1o′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4455
CMe
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3a
OH


4456
CMe
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3b
OH


4457
CMe
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3c
OH


4458
CMe
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3d
OH


4459
CMe
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3e
OH


4460
CMe
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3f
OH


4461
CMe
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3g
OH


4462
CMe
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3h
OH


4463
CMe
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3i
OH


4464
CMe
S
Q1o′
a bond
Me
a bond
NH
O
a bond
T3j
OH


4465
CMe
S
Q1o′
a bond
H
a bond
NH
S
NH
Q3a
OH


4466
CMe
S
Q1o′
a bond
H
a bond
NH
S
NH
Q3e
OH


4467
CMe
S
Q1o′
a bond
H
a bond
NH
S
NH
T3a
OH


4468
CMe
S
Q1o′
a bond
H
a bond
NH
S
NH
T3b
OH


4469
CMe
S
Q1o′
a bond
H
a bond
NH
S
NH
T3c
OH


4470
CMe
S
Q1o′
a bond
H
a bond
NH
S
NH
T3d
OH


4471
CMe
S
Q1o′
a bond
H
a bond
NH
S
NH
T3e
OH


4472
CMe
S
Q1o′
a bond
H
a bond
NH
S
NH
T3f
OH


4473
CMe
S
Q1a′
a bond
H
a bond
NH
S
NH
T3g
OH


4474
CMe
S
Q1o′
a bond
H
a bond
NH
S
NH
T3h
OH


4475
CMe
S
Q1o′
a bond
H
a bond
NH
S
NH
T3i
OH


4476
CMe
S
Q1o′
a bond
H
a bond
NH
S
NH
T3j
OH


4477
CMe
S
Q1o′
a bond
H
a bond
NH
S
a bond
Q3a
OH


4478
CMe
S
Q1o′
a bond
H
a bond
NH
S
a bond
Q3e
OH


4479
CMe
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3a
OH


4480
CMe
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3b
OH


4481
CMe
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3c
OH


4482
CMe
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3d
OH


4483
CMe
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3e
OH


4484
CMe
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3f
OH


4485
CMe
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3g
OH


4486
CMe
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3h
OH


4487
CMe
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3i
OH


4488
CMe
S
Q1o′
a bond
H
a bond
NH
S
a bond
T3j
OH


4489
CMe
S
Q1o′
a bond
H
a bond
NH
O
NH
Q3a
OH


4490
CMe
S
Q1o′
a bond
H
a bond
NH
O
NH
Q3e
OH


4491
CMe
S
Q1o′
a bond
H
a bond
NH
O
NH
T3a
OH


4492
CMe
S
Q1o′
a bond
H
a bond
NH
O
NH
T3b
OH


4493
CMe
S
Q1o′
a bond
H
a bond
NH
O
NH
T3c
OH


4494
CMe
S
Q1o′
a bond
H
a bond
NH
O
NH
T3d
OH


4495
CMe
S
Q1o′
a bond
H
a bond
NH
O
NH
T3e
OH


4496
CMe
S
Q1o′
a bond
H
a bond
NH
O
NH
T3f
OH


4497
CMe
S
Q1o′
a bond
H
a bond
NH
O
NH
T3g
OH


4498
CMe
S
Q1o′
a bond
H
a bond
NH
O
NH
T3h
OH


4499
CMe
S
Q1o′
a bond
H
a bond
NH
O
NH
T3i
OH


4500
CMe
S
Q1o′
a bond
H
a bond
NH
O
NH
T3j
OH


4501
CMe
S
Q1o′
a bond
H
a bond
NH
O
a bond
Q3a
OH


4502
CMe
S
Q1o′
a bond
H
a bond
NH
O
a bond
Q3e
OH


4503
CMe
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3a
OH


4504
CMe
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3b
OH


4505
CMe
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3c
OH


4506
CMe
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3d
OH


4507
CMe
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3e
OH


4508
CMe
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3f
OH


4509
CMe
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3g
OH


4510
CMe
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3h
OH


4511
CMe
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3i
OH


4512
CMe
S
Q1o′
a bond
H
a bond
NH
O
a bond
T3j
OH


4513
CMe
O
Q1o′
a bond
Me
a bond
NH
S
NH
Q3a
OH


4514
CMe
O
Q1o′
a bond
Me
a bond
NH
S
NH
Q3e
OH


4515
CMe
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3a
OH


4516
CMe
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3b
OH


4517
CMe
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3c
OH


4518
CMe
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3d
OH


4519
CMe
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3e
OH


4520
CMe
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3f
OH


4521
CMe
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3g
OH


4522
CMe
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3h
OH


4523
CMe
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3i
OH


4524
CMe
O
Q1o′
a bond
Me
a bond
NH
S
NH
T3j
OH


4525
CMe
O
Q1o′
a bond
Me
a bond
NH
S
a bond
Q3a
OH


4526
CMe
O
Q1o′
a bond
Me
a bond
NH
S
a bond
Q3e
OH


4527
CMe
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3a
OH


4528
CMe
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3b
OH


4529
CMe
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3c
OH


4530
CMe
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3d
OH


4531
CMe
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3e
OH


4532
CMe
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3f
OH


4533
CMe
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3g
OH


4534
CMe
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3h
OH


4535
CMe
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3i
OH


4536
CMe
O
Q1o′
a bond
Me
a bond
NH
S
a bond
T3j
OH


4537
CMe
O
Q1o′
a bond
Me
a bond
NH
O
NH
Q3a
OH


4538
CMe
O
Q1o′
a bond
Me
a bond
NH
O
NH
Q3e
OH


4539
CMe
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3a
OH


4540
CMe
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3b
OH


4541
CMe
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3c
OH


4542
CMe
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3d
OH


4543
CMe
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3e
OH


4544
CMe
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3f
OH


4545
CMe
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3g
OH


4546
CMe
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3h
OH


4547
CMe
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3i
OH


4548
CMe
O
Q1o′
a bond
Me
a bond
NH
O
NH
T3j
OH


4549
CMe
O
Q1o′
a bond
Me
a bond
NH
O
a bond
Q3a
OH


4550
CMe
O
Q1o′
a bond
Me
a bond
NH
O
a bond
Q3e
OH


4551
CMe
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3a
OH


4552
CMe
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3b
OH


4553
CMe
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3c
OH


4554
CMe
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3d
OH


4555
CMe
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3e
OH


4556
CMe
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3f
OH


4557
CMe
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3g
OH


4558
CMe
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3h
OH


4559
CMe
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3i
OH


4560
CMe
O
Q1o′
a bond
Me
a bond
NH
O
a bond
T3j
OH


4561
CMe
O
Q1o′
a bond
H
a bond
NH
S
NH
Q3a
OH


4562
CMe
O
Q1o′
a bond
H
a bond
NH
S
NH
Q3e
OH


4563
CMe
O
Q1o′
a bond
H
a bond
NH
S
NH
T3a
OH


4564
CMe
O
Q1o′
a bond
H
a bond
NH
S
NH
T3b
OH


4565
CMe
O
Q1o′
a bond
H
a bond
NH
S
NH
T3c
OH


4566
CMe
O
Q1o′
a bond
H
a bond
NH
S
NH
T3d
OH


4567
CMe
O
Q1o′
a bond
H
a bond
NH
S
NH
T3e
OH


4568
CMe
O
Q1o′
a bond
H
a bond
NH
S
NH
T3f
OH


4569
CMe
O
Q1o′
a bond
H
a bond
NH
S
NH
T3g
OH


4570
CMe
O
Q1o′
a bond
H
a bond
NH
S
NH
T3h
OH


4571
CMe
O
Q1o′
a bond
H
a bond
NH
S
NH
T3i
OH


4572
CMe
O
Q1o′
a bond
H
a bond
NH
S
NH
T3j
OH


4573
CMe
O
Q1o′
a bond
H
a bond
NH
S
a bond
Q3a
OH


4574
CMe
O
Q1o′
a bond
H
a bond
NH
S
a bond
Q3e
OH


4575
CMe
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3a
OH


4576
CMe
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3b
OH


4577
CMe
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3c
OH


4578
CMe
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3d
OH


4579
CMe
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3e
OH


4580
CMe
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3f
OH


4581
CMe
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3g
OH


4582
CMe
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3h
OH


4583
CMe
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3i
OH


4584
CMe
O
Q1o′
a bond
H
a bond
NH
S
a bond
T3j
OH


4585
CMe
O
Q1o′
a bond
H
a bond
NH
O
NH
Q3a
OH


4586
CMe
O
Q1o′
a bond
H
a bond
NH
O
NH
Q3e
OH


4587
CMe
O
Q1o′
a bond
H
a bond
NH
O
NH
T3a
OH


4588
CMe
O
Q1o′
a bond
H
a bond
NH
O
NH
T3b
OH


4589
CMe
O
Q1o′
a bond
H
a bond
NH
O
NH
T3c
OH


4590
CMe
O
Q1o′
a bond
H
a bond
NH
O
NH
T3d
OH


4591
CMe
O
Q1o′
a bond
H
a bond
NH
O
NH
T3e
OH


4592
CMe
O
Q1o′
a bond
H
a bond
NH
O
NH
T3f
OH


4593
CMe
O
Q1o′
a bond
H
a bond
NH
O
NH
T3g
OH


4594
CMe
O
Q1o′
a bond
H
a bond
NH
O
NH
T3h
OH


4595
CMe
O
Q1o′
a bond
H
a bond
NH
O
NH
T3i
OH


4596
CMe
O
Q1o′
a bond
H
a bond
NH
O
NH
T3j
OH


4597
CMe
O
Q1o′
a bond
H
a bond
NH
O
a bond
Q3a
OH


4598
CMe
O
Q1o′
a bond
H
a bond
NH
O
a bond
Q3e
OH


4599
CMe
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3a
OH


4600
CMe
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3b
OH


4601
CMe
O
O1o′
a bond
H
a bond
NH
O
a bond
T3c
OH


4602
CMe
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3d
OH


4603
CMe
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3e
OH


4604
CMe
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3f
OH


4605
CMe
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3g
OH


4606
CMe
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3h
OH


4607
CMe
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3i
OH


4608
CMe
O
Q1o′
a bond
H
a bond
NH
O
a bond
T3j
OH


























































































































74) The compounds in Table 6 wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 6, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 74), Q1a, Q1b, Q1c, Q1i, Q1j, Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 6 denote the following substituents).







75) The compounds in Table 6 wherein A, B, R1, L2, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 6, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 75), Q1a, Q1b, Q1c, Q1i, Q1j, Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 6 denote the following substituents).







76) The compounds in Table 6 wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 6, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 76), Q1a, Q1b, Q1c, Q1i, Q1j, Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 6 denote the following substituents).







77) The compounds in Table 6 wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 6, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 77), Q1a, Q1b, Q1c, Q1i, Q1j, Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 6 denote the following substituents).







78) The compounds in Table 6 wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 6, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 78), Q1a, Q1b, Q1c, Q1i, Q1j, Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 6 denote the following substituents).







79) The compounds in Table 6 wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 6, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 79), Q1a, Q1b, Q1c, Q1i, Q1j, Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 6 denote the following substituents).







80) The compounds in Table 6 wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 6, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 80), Q1a, Q1b, Q1c, Q1i, Q1j, Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 6 denote the following substituents).







81) The compounds in Table 6 wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 6, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 81), Q1a, Q1b, Q1c, Q1i, Q1j, Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 6 denote the following substituents).







82) The compounds in Table 6 wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 6, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 82), Q1a, Q1b, Q1c, Q1i, Q1j, Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 6 denote the following substituents).







83) The compounds in Table 6 wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 6, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 83), Q1a, Q1b, Q1c, Q1i, Q1j, Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 6 denote the following substituents).







84) The compound represented by any of 68) to 83) wherein X is converted to SH, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
85) The compound represented by any of 68) to 83) wherein X is converted to NH2, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
86) The compound represented by any of 68) to 83) wherein X is converted to OAc, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
87) The thrombopoietin receptor activators represented by any of 1) to 86).
88) Preventive, therapeutic and improving agents for diseases against which activation of the thrombopoietin receptor is effective which contain the thrombopoietin receptor activators represented by 87) or the formula (1), tautomers, prodrugs or pharmaceutically acceptable salts of the activators or solvates thereof, as an active ingredient.
89) Platelet increasing agents containing the thrombopoietin receptor activators represented by 87) or the formula (1), tautomers, prodrugs or pharmaceutically acceptable salts of the activators or solvates thereof, as an active ingredient.
90) Medicaments containing the compounds represented by any of 1) to 86) or the formula (1), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof, as an active ingredient.
In the present invention, the compounds of the present invention represented by the formula (1) may be present in the form of tautomers or geometrical isomers which undergo endocyclic or exocyclic isomerization, mixtures of tautomers or geometric isomers or mixtures of thereof. When the compounds of the present invention have an asymmetric center, whether or not resulting from an isomerization, the compounds of the present invention may be in the form of resolved optical isomers or in the form of mixtures containing them in certain ratios.
For example, furan compounds, thiophene compounds and pyrrole compounds of the present invention may be present in the form of tetronic acid (4-hydroxy-2(5H)-furanone) analogues, thiotetronic acid (4-hydroxy-2(5H)-thiophenone) analogues and tetraminic acid (4-hydroxy-3-pyrrolin-2-one) analogues as shown below by the formulae (2), (3) and (4), mixtures thereof or mixtures of isomers thereof.




The compounds of the present invention represented by the formula (1) or pharmaceutically acceptable salts thereof may be in the form of arbitrary crystals or arbitrary hydrates, depending on the production conditions. The present invention covers these crystals, hydrates and mixtures. They may be in the form of solvates with organic solvents such as acetone, ethanol and tetrahydrofuran, and the present invention covers any of these forms.
The compounds of the present invention represented by the formula (1) may be converted to pharmaceutically acceptable salts or may be liberated from the resulting salts, if necessary. The pharmaceutically acceptable salts of the present invention may be, for example, salts with alkali metals (such as lithium, sodium and potassium), alkaline earth metals (such as magnesium and calcium), ammonium, organic bases and amino acids. They may be salts with inorganic acids (such as hydrochloric acid, hydrobromic acid, phosphoric acid and sulfuric acid) and organic acids (such as acetic acid, citric acid, maleic acid, fumaric acid, benzenesulfonic acid and p-toluenesulfonic acid).
The compounds which serve as prodrugs are derivatives of the present invention having chemically or metabolically degradable groups which give pharmacologically active compounds of the present invention upon solvolysis or under physiological conditions in vivo. Methods for selecting or producing appropriate prodrugs are disclosed, for example, in Design of Prodrug (Elsevier, Amsterdam 1985). In the present invention, when the compound has a hydroxyl group, acyloxy derivatives obtained by reacting the compound with appropriate acyl halides or appropriate acid anhydrides may, for example, be mentioned as prodrugs. Acyloxys particularly preferred as prodrugs include —OCOC2H5, —OCO(t-Bu), —OCOC15H31, —OCO(m-CO2Na-Ph), —OCOCH2CH2CO2Na, —OCOCH(NH2)CH3, —OCOCH2N(CH3)2 and the like. When the compound of the present invention has an amino group, amide derivatives obtained by reacting the compound having an amino group with appropriate acid halides or appropriate mixed acid anhydrides may, for example, be mentioned as prodrugs. Amides particularly preferred as prodrugs include —NHCO(CH2)20OCH3, —NHCOCH(NH2)CH3 and the like. When the compound of the present invention has a carboxyl group, carboxylic acid esters with aliphatic alcohols or carboxylic acid esters obtained by the reaction with an alcoholic free hydroxyl group of 1,2- or 1,3-digylcerides may, for example, be mentioned as prodrugs. Particularly preferred prodrugs are methyl esters and ethyl esters.
The preventive, therapeutic and improving agents for diseases against which activation of the thrombopoietin receptor is effective or platelet increasing agents which contain the thrombopoietin receptor activators of the present invention, tautomers, prodrugs or pharmaceutically acceptable salts of the activators or solvates thereof as an active ingredient may usually be administered as oral medicines such as tablets, capsules, powder, granules, pills and syrup, as rectal medicines, percutaneous medicines or injections. The agents of the present invention may be administered as a single therapeutic agent or as a mixture with other therapeutic agents. Though they may be administered as they are, they are usually administered in the form of medical compositions. These pharmaceutical preparations can be obtained by adding pharmacologically and pharmaceutically acceptable additives by conventional methods. Namely, for oral medicines, ordinary excipients, lubricants, binders, disintegrants, humectants, plasticizers and coating agents may be used. Oral liquid preparations may be in the form of aqueous or oily suspensions, solutions, emulsions, syrups or elixirs or may be supplied as dry syrups to be mixed with water or other appropriate solvents before use. Such liquid preparations may contain ordinary additives such as suspending agents, perfumes, diluents and emulsifiers. In the case of rectal administration, they may be administered as suppositories. Suppositories may use an appropriate substance such as cacao butter, laurin tallow, Macrogol, glycerogelatin, Witepsol, sodium stearate and mixtures thereof as the base and may, if necessary, contain an emulsifier, a suspending agent, a preservative and the like. For injections, pharmaceutical ingredients such as distilled water for injection, physiological saline, 5% glucose solution, propylene glycol and other solvents or solubilizing agents, a pH regulator, an isotonizing agent and a stabilizer may be used to form aqueous dosage forms or dosage forms which need dissolution before use.
The dose of the agents of the present invention for administration to human is usually about from 0.1 to 1000 mg/human/day in the case of oral drugs or rectal administration and about from 0.05 mg to 500 mg/human/day in the case of injections, though it depends on the age and conditions of the patient. The above-mentioned ranges are mere examples, and the dose should be determined from the conditions of the patient.
The present invention is used when the use of compounds which have thrombopoietin receptor affinity and act as thrombopoietin receptor agonists are expected to improve pathological conditions. For example, hematological disorders accompanied by abnormal platelet count may be mentioned. Specifically, it is effective for therapy or prevention of human and mammalian diseases caused by abnormal megakaryopoiesis, especially those accompanied by thrombocytopenia. Examples of such diseases include thrombocytopenia accompanying chemotherapy or radiotherapy of cancer, thrombocytopenia accompanying antiviral therapy for diseases such as hepatitis C, thrombocytopenia caused by bone marrow transplantation, surgery and serious infections, or gastrointestinal bleeding, but such diseases are not restricted to those mentioned. Typical thrombocytopenias such as aplastic anemia, idiopathic thrombocytopenic purpura, myelodysplastic syndrome, hepatic disease, HIV infection and thrombopoietin deficiency are also targets of the agents of the present invention. The present invention may be used as a peripheral stem cell mobilizer, a megakaryoblastic or megakaryocytic leukemia cell differentiation inducer and a platelet increasing agent for platelet donors. In addition, potential applications include therapeutic angiogenesis based on differentiation and proliferation of vascular endothelial cells and endothelial progenitor cells, prevention and therapy of arteriosclerosis, myocardial infarction, unstable angina, peripheral artery occlusive disease, but there is no restriction.
The compounds represented by the formula (1) are prepared by the process represented by the formula (5) illustrated below.




The reaction of the compound (I) with a —NH2 compound (II) in a solvent, if necessary in the presence of a catalyst, under heating with stirring gives a desired compound or its precursor. The precursor may be, if necessary, hydrolyzed, deprotected, reduced or oxidized to a desired compound. The compounds of the present invention usually can be purified by column chromatography, thin layer chromatography, high performance liquid chromatography (HPLC) or high performance liquid chromatography-mass spectrometry (LC-MS) and, if necessary, they may be obtained with high purity by recrystallization or washing with solvents.
For the syntheses of the intermediates (I), syntheses of the following heterocyclic compounds may be referred to.

    1) Pyrazole (the formula (6))
    J. Chem. Soc. Perkin. TransI, p. 81, (1985)
    2) Isothiazole (the formula (7))
    Liebigs. Annalen. der. Chemie., 10, 1534-1546 (1979)
    3) Isoxazole (the formula (8))
    Synthesis, 10, 664-665 (1975)
    4) Thiophene (the formula (9))
    JP-A-48-026755
    5) Furan (the formula (10))
    J. Org. Chem., 21, 1492-1509 (1956)
    6) Pyrrole (the formula (11))
    J. Heterocyclic Chem., 30, 1253 (1993) and Tetrahedron, 50(26), 7849-56 (1994)
    7) Tetronic acid (4-hydroxy-2(5H)-furanone) analogue (the formula (12))
    Synthesis, 7, 564-566 (1988) and Yakugaku Zasshi, 96(4), 536-543 (1976)
    8) Tetraminic acid (4-hydroxy-3-pyrrolin-2-one) analogue (the formula (13))
    Synthesis, 2, 190-192 (1987) and Agric. Biol. Chem., 43(8), 1641-1646 (1979)















For synthesis of the —NH2 compounds (II), for example, when L3=NH, the following may be referred to.

    1) L4=a bond, Y═O
    Synthetic Commun., 28(7), 1223-1231 (1998), J. Chem. Soc., 1225 (1948) and J. Chem. Soc., 2831 (1952)
    2) L4=NH, Y═O
    J. Am. Chem. Soc., 46, 2813 (1924) and J. Chem. Soc., 2654 (1952)
    3) L4=NH, Y═S
    Can. J. Chem., 35, 834 (1957)
    4) L4=CH2, Y═O
    J. Org. Chem., 30, 2487 (1965)
    5) L4=O, Y═O
    Bull. Soc. Chim. Belg., 68, 409, (1959)


EXAMPLES
Now, the present invention will be described in further detail with reference to Reference Synthetic Examples, Synthetic Examples, Assay Examples and Formulation Examples. However, it should be understood that the present invention is by no means restricted by these specific Examples.
The 1H-NMR analysis was carried out at 300 MHz.
In the REFERENCE SYNTHETIC EXAMPLE 59-75 and the SYNTHETIC EXAMPLE 124-240, LC/MS was measured on the following conditions.
LC/MS condition 1


    column: Waters SunFire C18(3.5 μm, 4.6×30 mm)
    elute: MeCN/0.1% aq.HCOOH (10/90 to 30/70)

LC/MS condition 2

    column: Waters SunFire C18(3.5 μm, 4.6×30 mm)
    elute: MeCN/0.1% aq.HCOOH (10/90 to 60/40)

LC/MS condition 3

    column: Waters SunFire C18(3.5 μm, 4.6×30 mm)
    elute: MeCN/0.1% aq.HCOOH (10/90 to 85/15)

LC/MS condition 4

    column: Waters Xterra MSC18(5 μm, 4.6×50 mm)
    elute: MeCN/0.1% aq.HCOOH (10/90 to 30/70)

LC/MS condition 5

    column: Waters Xterra MSC18(5 μm, 4.6×50 mm)
    elute: MeCN/0.1% aq.HCOOH (10/90 to 60/40)

LC/MS condition 6

    column: Waters Xterra MSC18(5 μm, 4.6×50 mm)
    elute: MeCN/0.1% aq.HCOOH (10/90 to 85/15)

LC/MS condition 7

    column: Waters Xterra MSC18(5 μm, 4.6×50 mm)
    elute: MeCN/0.1% aq.HCOOH (20/80 to 100/0)

LC/MS condition 8

    column: Waters Xterra MSC18(3.5 μm, 2.1×20 mm)
    elute: MeCN/0.2% aq.HCOOH (20/80 to 90/10)

LC/MS condition 9

    column: Waters SunFire C18(3.5 μm, 4.6×30 mm)
    elute: MeCN/0.1% aq.HCOOH (20/80 to 100/0)


Reference Synthetic Example 1
Synthesis of 2-oxopropanal methylhydrazone
A mixed solution of methylhydrazine (8.34 mL, 158.22 mmol) in acetic acid (15 mL) and water (60 mL) was added to 10% methylglyoxal aqueous solution (92.5 mL, 151.21 mmol), and the mixture was stirred at room temperature for about 24 hours. The reaction solution was extracted with chloroform three times, and the extract was dried, filtered and concentrated. Purification of the resulting black solution by vacuum distillation gave the desired product as a yellow solid (5.357 g, yield 35%).
1H-NMR (ppm in CDCl3) δ 6.86 (s, 1H), 6.59 (br.s, 1H), 2.98 (d, J=4.2 Hz, 3H), 2.30 (s, 3H) LC-MS (ESI) 100 (M+)
Reference Synthetic Example 2
Synthesis of 2-oxopropanal ethylhydrazone
Ethylhydrazine (8.46 mmol, 556 mg) was dissolved in methanol (4 mL), and the reactor was cooled to 0° C. Methylglyoxal (40% in H2O, 9.3 mmol, 1.42 mL) was added, and the mixture was stirred for 15 minutes at the same temperature and then for 2.5 hours at room temperature. After addition of water, it was extracted with chloroform three times. The resulting organic layer was dried over anhydrous magnesium sulfate and filtered, and the solvent was evaporated with an evaporator. The residue was dried by means of a vacuum pump to give the desired product as an orange liquid (0.955 g (crude), yield 99%).
1H-NMR (ppm in CDCl3) δ 9.29 (s, 1H), 6.32 (br.s, 1H), 3.58 (q, J=7.1 Hz, 1H), 3.57 (q, J=7.1 Hz, 1H), 1.79 (s, 3H), 1.29 (t, J=7.1 Hz, 3H)
Reference Synthetic Example 3
Synthesis of (3,4-dichlorophenyl)(oxo)acetaldehyde
3,4-dichloroacetophenone (5.39 mmol, 1.02 g) was dissolved in dimethyl sulfoxide (13 mL), and 48% hydrobromic acid (1.83 mL) was gradually added at room temperature. The mixture was stirred overnight at 60° C., and then the reactor was cooled to room temperature. The reaction solution was poured into water (50 mL) at 0° C. and stirred for about 1 hour. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the desired product as a pale yellow solid (0.780 g, yield 71%).
1H-NMR (ppm in DMSO-d6) δ 8.26 (d, J=2.0 Hz, 1H), 8.01 (dd, J=2.0, 8.6 Hz, 1H), 7.82 (d, J=8.6 Hz, 1H), 7.01 (d, J=6.6 Hz, 2H, H2O), 5.61 (br.s, 1H)
MS (EI) 173 (M+—CHO)
Reference Synthetic Example 4
Synthesis of (4-t-butylphenyl)(oxo)acetaldehyde
4-t-Butylacetophenone (100 mmol, 18.74 mL) was dissolved in dimethyl sulfoxide (104 mL), then the reactor was cooled to 0° C., and 48% hydrobromic acid (34 mL) was gradually added. After 18 hours of stirring at 70° C., the reaction solution was poured into water (400 mL) and stirred for 24 hours. The precipitated yellow solid was recovered by filtration, washed with n-hexane several times and dried by means of a vacuum pump to give the desired product as a pale yellow solid (13.89 g, yield 73%).
1H-NMR (ppm in DMSO-d6) δ 8.01 (ABq, J=8.4 Hz, 2H), 7.51 (ABq, J=8.4 Hz, 2H), 6.01 (s, 1H), 1.30 (s, 9H) LC-MS (ESI) 190 (M+)
Reference Synthetic Example 5
Synthesis of (3,4-dimethylphenyl)(oxo)acetaldehyde
3,4-dimethylacetophenone (13.52 mmol, 2.0 g) was dissolved in dimethyl sulfoxide (13 mL), and 48% hydrobromic acid (5.4 mL) was gradually added at room temperature. After 16 hours of stirring at 70° C., the reactor was cooled to room temperature. The reaction solution was poured into water and stirred for about 16 hours. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the desired product as a white solid (1.234 g, yield 57%).
1H-NMR (ppm in DMSO-d6) δ 7.83-7.80 (multi, 2H), 7.33 (br.s, 2H, H2O), 7.26 (d, J=7.5 Hz, 1H), 5.96 (br.s, 1H), 2.28 (s, 3H), 2.22 (s, 3H)
Reference Synthetic Example 6
Synthesis of (4-n-pentylphenyl)(oxo)acetaldehyde
4-n-Pentylacetophenone (10.66 mmol, 2.028 g) was dissolved in dimethyl sulfoxide (13 mL), and 48% hydrobromic acid (5.4 mL) was gradually added at room temperature. After 9.5 hours of stirring at 70° C., the reactor was cooled to room temperature. The reaction solution was poured into water and stirred for about 16 hours. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the desired product as a pale yellow solid (2.1784 g (crude), 100%).
1H-NMR (ppm in DMSO-d6) δ 7.99 (ABq, J=8.3 Hz, 2H), 7.33 (ABq, J=8.3 Hz, 2H), 6.67 (br.s, 2H, H2O), 5.67 (br.s, 1H), 2.69-2.61 (multi, 2H), 1.66-1.50 (multi, 2H), 1.36-1.20 (multi, 4H), 0.88-0.83 (multi, 3H).
Reference Synthetic Example 7
Synthesis of (4-trifluoromethylphenyl)(oxo)acetaldehyde
4-Trifluoromethylacetophenone (11.14 mmol, 2.096 g) was dissolved in dimethyl sulfoxide (13 mL), and 48% hydrobromic acid (5.4 mL) was gradually added at room temperature. After 9.5 hours of stirring at 70° C., the reactor was cooled to room temperature. The reaction solution was poured into water and stirred for about 16 hours. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the desired product as a yellow solid (1.3116 g, yield 59%).
1H-NMR (ppm in DMSO-d6) δ 8.27 (ABq, J=8.3 Hz, 2H), 7.90 (ABq, J=8.3 Hz, 2H), 6.97 (br.s, 2H, H2O), 5.68 (br.s, 1H)
Reference Synthetic Example 8
Synthesis of oxo [3-(trifluoromethyl)phenyl]acetaldehyde
3-Trifluoromethylacetophenone (11.80 mmol, 2.22 g) was dissolved in dimethyl sulfoxide (13 mL), and 48% hydrobromic acid (5.4 mL) was gradually added at room temperature. After overnight stirring at 70° C., the reactor was cooled to room temperature. After addition of water, the reaction solution was extracted with chloroform, and the extract was dried and filtered, and the solvent was evaporated to give the desired product as a yellow liquid (3.04 g (crude), yield 128%).
Reference Synthetic Example 9
Synthesis of (3-bromo-4-fluorophenyl)(oxo)acetaldehyde
From 3-bromo-4-fluoroacetophenone, the desired product was obtained in the same manner as in Reference Synthetic Example 8 as a yellow liquid (crude, yield 114%).
Reference Synthetic Example 10
Synthesis of (3,5-dimethylphenyl)(oxo)acetaldehyde
From 3,5-dimethylacetophenone, the desired product was obtained in the same manner as in Reference Synthetic Example 8 as a yellow solid (crude, yield 104%).
Reference Synthetic Example 11
Synthesis of (4-ethylphenyl)(oxo)acetaldehyde
4-Ethylacetophenone (26.72 mmol, 4 mL) was dissolved in dimethyl sulfoxide (27 mL), and 48% hydrobromic acid (11 mL) was gradually added at room temperature. After overnight stirring at 70° C., the reactor was cooled to room temperature. The reaction solution was poured into water (50 mL) and stirred for about 1 hour. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the desired product as a white solid (2.44 g, yield 56%).
Reference Synthetic Example 12
Synthesis of (4-isopropylphenyl)(oxo)acetaldehyde
From 4-isopropylacetophenone, the desired product was obtained in the same manner as in Reference Synthetic Example 8 as a yellow solid (crude, yield 103%).
Reference Synthetic Example 13
Synthesis of oxo(4-n-propylphenyl)acetaldehyde
From 4-n-propylacetophenone, the desired product was obtained in the same manner as in Reference Synthetic Example 11 as a yellow liquid (crude, yield 92%).
Reference Synthetic Example 14
Synthesis of (4-n-hexylphenyl)(oxo)acetaldehyde
From 4-n-hexylacetophenone, the desired product was obtained in the same manner as in Reference Synthetic Example 11 as a yellow solid (crude, yield 131%).
Reference Synthetic Example 15
Synthesis of (4-isobutylphenyl)(oxo)acetaldehyde
From 4-isobutylacetophenone, the desired product was obtained in the same manner as in Reference Synthetic Example 8 as a yellow liquid (crude, yield 108%).
Reference Synthetic Example 16
Synthesis of 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-ethoxycarbonylthiophene
60% Sodium hydride (28 mg, 0.69 mmol) was added to a solution of 2-(4-t-butylphenyl)-3-hydroxy-4-ethoxycarbonylthiophene (0.20 g, 0.66 mmol) obtained in accordance with JP-A-48-26755 in dimethylformamide (1.0 mL) at room temperature, and the reaction solution was stirred at 60° C. for 15 minutes. After the reaction solution was cooled to room temperature, chloromethyl methyl ether (0.055 mL, 0.73 mmol) was added dropwise, and the reaction solution was stirred at room temperature for another 5 hours. After addition of saturated aqueous ammonium chloride, the reaction solution was extracted with ethyl acetate, and the organic layer was washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate. The organic layer was concentrated and purified by silica gel column chromatography (chloroform) to give the desired product as a colorless oil (212 mg, yield 91%).
1H-NMR (ppm in CDCl3) δ 1.34 (s, 9H), 1.38 (t, J=7.2 Hz, 3H), 3.23 (s, 3H), 4.34 (q, J=7.2 Hz, 2H), 5.00 (s, 2H), 7.41-7.44 (m, 2H), 7.60-7.63 (m, 2H), 7.97 (s, 1H). LC/MS (ES+) 371 (Na+ adduct).
Reference Synthetic Example 17
Synthesis of 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-ethoxycarbonylthiophene
From 2-(3,4-dichlorophenyl)-3-hydroxy-4-ethoxycarbonylthiophene (7.7 g, 24 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 16 as a colorless oil (5.4 g, yield 62%).
1H-NMR (ppm in CDCl3) δ 1.38 (t, J=7.2 Hz, 3H), 3.27 (s, 3H), 4.34 (q, J=7.2 Hz, 2H), 5.06 (s, 2H), 7.46-7.54 (m, 2H), 7.86 (d,J=1.9 Hz, 1H), 8.04 (s, 1H).
Reference Synthetic Example 18
Synthesis of 2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-ethoxycarbonylthiophene
From 2-(4-trifluoromethylphenyl)-3-hydroxy-4-ethoxycarbonylthiophene (1.6 g, 5.2 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 16 as a brown oil (1.8 g, yield 95%).
1H-NMR (ppm in CDCl3) δ 1.39 (t, J=7.2 Hz, 3H), 3.21 (s, 3H), 4.35 (q, J=7.2 Hz, 2H), 5.05 (s, 2H), 7.67 (d, J=8.3 Hz, 2H), 7.83 (d, J=8.3 Hz, 2H), 8.07 (s, 1H).
Reference Synthetic Example 19
Synthesis of 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-hydroxymethylthiophene
To lithium aluminium hydride (27 mg, 0.72 mmol) in THF (0.86 mL), 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-ethoxycarbonylthiophene (0.21 g, 0.60 mmol) in THF (0.86 mL) was added dropwise under cooling with ice, and the reaction solution was stirred under cooling with ice for 1 hour. After addition of saturated aqueous ammonium chloride, the reaction solution was extracted with ethyl acetate, and the organic layer was washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate, concentrated and purified by silica gel column chromatography (n-hexane/ethyl acetate=3/1) to give the desired product as a colorless oil (87 mg, yield 47%).
1H-NMR (ppm in CDCl3) δ 1.25 (s, 9H), 3.05 (bs, 1H), 3.40 (s, 3H), 4.46 (d, J=5.8 Hz, 2H), 4.81 (s, 2H), 7.02 (s, 1H), 7.30-7.34 (m, 2H), 7.47-7.50 (m, 2H). LC/MS (ES+) 329 (Na+ adduct).
Reference Synthetic Example 20
Synthesis of 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-hydroxymethylthiophene
From 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-ethoxycarbonylthiophene (5.0 g, 14 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 19 as a colorless oil (4.3 g, 98%).
1H-NMR (ppm in CDCl3) δ 3.51 (s, 3H), 4.56 (d, J=5.8 Hz, 2H), 4.91 (s, 2H) 7.21 (s, 1H), 7.43-7.51 (m, 2H), 7.89 (s, 1H). LC/MS (ES+) 340, 342 (Na+ adduct). LC/MS (ES−) 363, 364, 365 (HCO2− adduct).
Reference Synthetic Example 21
Synthesis of 2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-hydroxymethylthiophene
From 2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-ethoxycarbonylthiophene (1.8 g, 4.9 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 19 as a yellow oil (1.4 g, yield 92%).
1H-NMR (ppm in CDCl3) δ 3.50 (s, 3H), 4.57 (s, 2H), 4.91 (s, 2H), 7.24 (s, 1H), 7.64 (d, J=8.4 Hz, 2H), 7.78 (d, J=8.4 Hz, 2H). LC/MS (ES+) 341 (Na+adduct).
Reference Synthetic Example 22
Synthesis of 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-formylthiophene
Dimethyl sulfoxide (0.050 mL, 0.70 mmol) in dichloromethane (0.28 mL) was added to oxalyl chloride (0.049 mL, 0.56 mmol) in dichloromethane (2.8 mL) at −78° C., and after 10 minutes of stirring at −78° C., 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-hydroxymethylthiophene 87 mg, 0.28 mmol) in dichloromethane (0.93 mL) was added dropwise. After the addition, the reaction solution was stirred at −78° C. for 20 minutes and at −40 to −50° C. for 1 hour. Triethylamine (0.28 mL, 2.0 mmol) was added dropwise, and the reaction solution was stirred for another 20 minutes under cooling with ice. After addition of saturated aqueous ammonium chloride, the reaction solution was extracted with chloroform, and the organic layer was washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and concentrated to give the desired product as a brown oil (58 mg, yield 68%).
1H-NMR (ppm in CDCl3) δ 1.25 (s, 9H), 3.24 (s, 3H), 4.91 (s, 2H), 7.34-7.38 (m, 2H), 7.50-7.54 (m, 2H), 7.91 (s, 1H), 9.82 (s, 1H). LC/MS (ES+) 305.
Reference Synthetic Example 23
Synthesis of 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-formylthiophene
From 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-hydroxymethylthiophene (4.3 g, 14 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 22 as a colorless oil (5.2 g, yield 122%).
1H-NMR (ppm in CDCl3) δ 3.50 (s, 3H), 5.04 (s, 2H), 7.48-7.54 (m, 2H), 7.84 (d, J=1.7 Hz, 1H), 8.04 (s, 1H), 9.88 (s, 1H).
Reference Synthetic Example 24
Synthesis of 2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-formylthiophene
2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-hydroxymethylthiophene (1.4 g, 4.3 mmol) in chloroform (22 ml) was stirred with manganese dioxide (3.7 g, 43 mmol) at room temperature for 20 hours and at 50° C. for 3 hours. The reaction solution was filtered, and the filtrate was concentrated and purified by silica gel column chromatography (n-hexane/ethyl acetate=3/1) to give the desired product as a colorless oil (0.79 g, yield 57%).
1H-NMR (ppm in CDCl3) δ 3.29 (s, 3H), 5.03 (s, 2H), 7.68 (d, J=8.5 Hz, 2H), 7.82 (d, J=8.5 Hz, 2H), 8.08 (s, 1H), 9.91 (s, 1H). LC/MS (ES+) 339 (Na+ adduct).
Reference Synthetic Example 25
Synthesis of 2-(4-t-butylphenyl)-3-hydroxy-4-formylthiophene
To 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-formylthiophene (0.20 g, 0.66 mmol) in 1,4-dioxane (1.3 mL), 1 M hydrochloric acid (0.66 mL, 0.66 mmol) was added dropwise, and the reaction solution was stirred at 65° C. for 1 hour and at 80° C. for 1 hour. After addition of water, the reaction solution was extracted with ethyl acetate, and the organic layer was washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate, concentrated and purified by silica gel column chromatography (chloroform) to give the desired product as a reddish brown oil (0.12 g, yield 68%).
1H-NMR (ppm in CDCl3) δ 1.38 (s, 9H), 7.43 (d, J=8.4 Hz, 2H), 7.70 (d, J=8.4 Hz, 2H), 7.88 (s, 1H), 9.24 (s, 1H), 9.85 (s, 1H).
Reference Synthetic Example 26
Synthesis of 2-(3,4-dichlorophenyl)-3-hydroxy-4-formylthiophene
From 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-formylthiophene (1.7 g, 5.4 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 25 as a brown oil (1.2 g, yield 83%).
1H-NMR (ppm in DMSO-d6) δ 7.68 (s, 2H), 7.80 (s, 1H), 8.48 (s, 1H), 9.89 (s, 1H), 10.07 (s, 1H). LC/MS (ES−) 271, 273.
Reference Synthetic Example 27
Synthesis of 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-(1-hydroxyethyl)thiophene
3.0 M Ethyl ether solution (2.0 mL, 6.0 mmol) of methylmagnesium bromide was added dropwise to 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-formylthiophene (0.77 g, 2.5 mmol) in THF (2.5 mL) under cooling with ice, and the reaction solution was stirred for 1 hour under cooling with ice. After addition of saturated aqueous ammonium chloride, the reaction solution was extracted with ethyl acetate, and the organic layer was washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate, concentrated and purified by silica gel column chromatography (n-hexane/ethyl acetate=9/1) to give the desired product as a pale yellow oil (0.64 g, yield 80%).
1H-NMR (ppm in CDCl3) δ 1.34 (s, 9H), 1.58-1.60 (m, 3H), 3.24 (bs, 1H), 3.48 (S, 3H), 4.83-4.85 (m, 1H), 4.92-4.95 (m, 2H), 7.08 (s, 1H), 7.38-7.42 (m, 2H), 7.54-7.57 (m, 2H). LC/MS (ES+) 343 (Na+ adduct).
Reference Synthetic Example 28
Synthesis of 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-(1-hydroxyethyl)thiophene
From 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-formylthiophene (0.75 g, 2.4 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 27 as a pale yellow oil (0.76 g, yield 95%).
1H-NMR (ppm in CDCl3) δ 1.57-1.62 (m, 3H), 3.05 (bs, 1H), 3.50 (s, 3H), 4.82-4.85 (m, 1H), 4.90-4.95 (m, 2H), 7.17 (d, J=2.5 Hz, 1H), 7.53-7.59 (m, 2H), 7.77 (s, 1H).
Reference Synthetic Example 29
Synthesis of 2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-(1-hydroxyethyl)thiophene
From 2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-formylthiophene (0.79 g, 2.5 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 27 as a yellow oil (0.76 g, yield 92%).
1H-NMR (ppm in CDCl3) δ 1.59 (d, J=6.3 Hz, 3H), 3.09 (bs, 1H), 3.48 (s, 3H), 4.83 (d, J=6.3 Hz, 1H), 4.92 (s, 2H), 7.20 (s, 1H), 7.64 (d, J=8.4 Hz, 2H), 7.76 (d, J=8.4 Hz, 2H).
Reference Synthetic Example 30
Synthesis of 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-methylcarbonylthiophene
2-(4-t-Butylphenyl)-3-methoxymethyloxy-4-(1-hydroxyethyl)thiophene (0.64 g, 2.0 mmol) in dichloromethane (13 mL) was stirred with celite (2.0 g) and pyridinium chlorochromate (0.86 g, 4.0 mmol) at room temperature for 1 hour. The reaction solution was filtered through celite, and the filtrate was concentrated and purified by silica gel column chromatography (n-hexane/ethyl acetate=1/1) to give the desired product as a brown solid (0.53 g, yield 83%).
1H-NMR (ppm in CDCl3) δ 1.34 (s, 9H), 2.57 (s, 3H), 3.23 (s, 3H), 4.93 (s, 2H), 7.41-7.44 (m, 2H), 7.57-7.61 (m, 2H), 7.88 (s, 1H).
Reference Synthetic Example 31
Synthesis of 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-methylcarbonylthiophene
From 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-(1-hydroxyethyl)thiophene (0.76 g, 2.3 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 30 as a colorless solid (0.62 g, yield 81%).
1H-NMR (ppm in CDCl3) δ 2.56 (s, 3H), 3.27 (s, 3H), 4.98 (s, 2H), 7.46-7.54 (m, 2H), 7.84 (d, J=1.9 Hz, 1H), 7.95 (s, 1H).
Reference Synthetic Example 32
Synthesis of 2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-methylcarbonylthiophene
From 2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-(1-hydroxyethyl)thiophene (0.76 g, 2.3 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 30 as a yellow oil (0.64 g, yield 84%).
1H-NMR (ppm in CDCl3) δ 2.57 (s, 3H), 3.20 (s, 3H), 4.96 (s, 2H), 7.67 (d, J=8.6 Hz, 2H), 7.82 (d, J=8.6 Hz, 2H), 7.98 (s, 1H).
Reference Synthetic Example 33
Synthesis of 2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene
From 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-methylcarbonylthiophene (0.53 g, 1.7 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 25 as a yellow solid (0.38 g, yield 80%).
1H-NMR (ppm in CDCl3) δ 1.33 (s, 9H), 2.56 (s, 3H), 7.40-7.44 (m, 2H), 7.69-7.74 (m, 2H), 7.85 (s, 1H), 10.28 (s, 1H). LC/MS (ES+) 275.
Reference Synthetic Example 34
Synthesis of 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene
From 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-methylcarbonylthiophene (0.62 g, 1.9 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 25 as a yellow solid (0.31 g, yield 57%).
1H-NMR (ppm in DMSO-d6) δ 2.58 (s, 3H), 7.65-7.66 (m, 2H), 7.97 (d, J=1.0 Hz, 1H), 8.71 (s, 1H), 10.59 (s, 1H).
Reference Synthetic Example 35
Synthesis of 2-(4-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene
From 2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-methylcarbonylthiophene (0.64 g, 1.9 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 25 as a yellow solid (0.47 g, yield 86%).
1H-NMR (ppm in CDCl3) δ 2.59 (s, 3H), 7.63 (d, J=8.3 Hz, 2H), 7.91 (d, J=8.3 Hz, 2H), 7.96 (s, 1H), 10.57 (s, 1H). LC/MS (ES+) 287.
Reference Synthetic Example 36
Synthesis of oxo(phenyl)acetaldehyde methylhydrazone
A mixed solution of methylhydrazine (0.554 mL, 10.5 mmol)/acetic acid (1 mL)/water (7.6 mL) was added to phenylglyoxal (1.34 g, 10 mmol) in water (130 mL), and the mixture was stirred at room temperature for 20 hours. The reaction solution was extracted with chloroform, and the extract was dried, filtered, evaporated and dried by means of a vacuum pump to give oxo(phenyl)acetaldehyde methylhydrazone (1.44 g (crude), yield 89%) as a yellow solid.
Reference Synthetic Example 37
Synthesis of 4-hydrazinocarbonylmethyl benzoate
The known procedure disclosed in the literature (Synthetic Communications, 28(7), 1223-1231, (1998)) was followed using monomethyl terephthalate and tetramethylfluoroformamidinium hexafluorophosphate to give 1.36 g of the desired product as a colorless solid (yield 70%).
1H-NMR (ppm in DMSO-d6) δ 3.86 (s, 3H), 4.56 (s, 2H), 7.93 (d, J=8.3 Hz, 2H), 8.02 (d, J=8.3 Hz, 2H), 9.96 (bs, 1H).
Reference Synthetic Example 38
Synthesis of 5-methoxycarbonyl-2-thiophenecarboxylic acid
Thiophene-2,5-dicarboxylic acid (1.72 g, 10 mmol) and sodium carbonate (3.18 g, 30 mmol) suspended in dimethylformamide (25 mL) were stirred with methyl iodide (623 μL) at room temperature overnight. The sodium salt of the desired product was extracted with water, and 12 M hydrochloric acid was added to the combined aqueous layer. The desired product was extracted with ethyl acetate, and the combined organic layer was washed with saturated aqueous ammonium chloride, dried over anhydrous magnesium sulfate and purified by silica gel column chromatography to give 0.49 g of the desired product as a colorless solid (yield 28%).
1H-NMR (ppm in CDCl3) δ 3.93 (s, 3H), 7.77 (d, J=4.2 Hz, 1H), 7.83 (d, J=5 4.2 Hz, 1H). LC/MS(ESI) 186(M+).
Reference Synthetic Example 39
Synthesis of methyl 5-hydrazinocarbonyl-2-thiophenecarboxylate
The known procedure disclosed in the literature (J. Heterocyclic Chem., 28, 17, (1991).) was followed using 5-methoxycarbonyl-2-thiophenecarboxylic acid synthesized in Reference Synthetic Example 38, thionyl chloride and hydrazine monohydrate to give 144 mg of the desired product as a white solid (yield 72%).
1H-NMR (ppm in DMSO-d6) δ 3.84 (s, 3H), 4.57 (brs, 2H), 7.72 (d, J=4.2 Hz, 1H), 7.79 (d, J=4.2 Hz, 1H), 10.06 (brs, 1H). LC/MS(ESI) 200(M+).
Reference Synthetic Example 40
Synthesis of methyl 2-nitro-4-hydrazinocarbonylbenzoate
From 4-methoxycarbonyl-3-nitrobenzoic acid, thionyl chloride and hydrazine monohydrate, 758 mg of the desired product was obtained in the same manner as in Reference Synthetic Example 39 as a white solid (yield 79%).
1H-NMR (ppm in DMSO-d6) δ 3.88 (s, 3H), 4.67 (brs, 2H), 7.96 (d, J=7.8 Hz, 1H), 8.24 (dd, J=1.8, 7.8 Hz, 1H), 8.44 (d, J=1.8 Hz, 1H). LC/MS (ESI) 239(M+).
Reference Synthetic Example 41
Synthesis of methyl 2-chloro-4-hydrazinocarbonylbenzoate
1) Synthesis of 3-chloro-4-methoxycarbonylbenzoic acid
To 3-amino-4-methoxycarbonylbenzoic acid (0.98 g, 5 mmol) suspended in 12 M hydrochloric acid (25 mL) and acetic acid (25 mL), an aqueous solution (10 mL) of sodium nitrite (0.35 g, 5 mmol) was added at −10° C., and the resulting solution was stirred for 30 minutes. The solution was added to copper chloride (I) (0.99 g, 10 mmol) in 12 M hydrochloric acid (25 mL) at −10° C., and the resulting reaction mixture was stirred at room temperature for 1 hour. After addition of ethyl acetate, the reaction mixture was washed with water, dried over magnesium sulfate, filtered through celite and purified by silica gel column chromatography to give 0.44 g of the desired product as a colorless solid (yield 39%).
1H-NMR (ppm in DMSO-d6) δ 3.98 (s, 3H), 7.89 (d, J=8.1 Hz, 1H), 8.02 (dd, J=1.5, 8.1 Hz, 1H), 8.17 (d, J=1.5 Hz, 1H). LC/MS (ESI) 214 (M+ 35Cl), 216 (M+ 37Cl).
2) Synthesis of methyl 2-chloro-4-hydrazinocarbonylbenzoate
From 3-chloro-4-methoxycarbonylbenzoic acid, thionyl chloride and hydrazine monohydrate, 423 mg of the desired product was obtained in the same manner as in Reference Synthesis Example 39 as a while solid (yield 93%).
1H-NMR (ppm in DMSO-6) δ 3.88 (s, 3H), 4.63 (brs, 2H), 7.87-7.96 (m, 3H), 10.05 (brs, 1H). LC/MS (ESI) 228 (M+ 35Cl), 230 (M+ 37Cl).
Reference Synthetic Example 42
Synthesis of methyl 2-bromo-4-hydrazinocarbonylbenzoate
1) Synthesis of 3-bromo-4-methoxycarbonylbenzoic acid
To 3-amino-4-methoxycarbonylbenzoic acid (1.95 g, 10 mmol) suspended in 48% hydrobromic acid (50 mL) and acetic acid (50 mL), an aqueous solution (20 mL) of sodium nitrite (0.69 g, 10 mmol) was added at −10° C., and the resulting solution was stirred for 30 minutes. The solution was added to copper bromide (I) (1.44 g, 10 mmol) in 48% hydrobromic acid (50 mL) at −10° C., and the resulting reaction mixture was stirred at room temperature for 1 hour. After addition of ethyl acetate, the reaction mixture was washed with water, dried over magnesium sulfate, filtered through celite and purified by silica gel column chromatography to give 1.70 g of the desired product as a colorless solid (yield 59%).
1H-NMR (ppm in DMSO-6) δ 3.97 (s, 3H), 7.84 (d, J=8.1 Hz, 1H), 8.07 (dd, J=1.5, 8.1 Hz, 1H), 8.37 (d, J=1.5 Hz, 1H). LC/MS (ESI) 258 (M+ 79Br), 260 (M+ 81Br).
2) Synthesis of methyl 2-bromo-4-hydrazinocarbonylbenzoate
From 3-bromo-4-methoxycarbonylbenzoic acid, thionyl chloride and hydrazine monohydrate, 489 mg of the desired product was obtained in the same manner as in Reference Synthesis Example 39 as a while solid (yield 90%).
1H-NMR (ppm in DMSO-6) δ 3.88 (s, 3H), 4.60 (brs, 2H), 7.83 (d, J=8.1 Hz, 1H), 7.90 (dd, J=1.5, 8.1 Hz, 1H), 8.13 (d, J=1.5 Hz, 1H), 10.04 (brs, 1H). LC/MS (ESI) 272 (M+ 79Br), 274 (M+ 81Br).
Reference Synthetic Example 43
Synthesis of methyl 4-hydrazinocarbonyl-2-hydroxybenzoate
1) Synthesis of 3-hydroxy-4-methoxycarbonylbenzoic acid
To 3-amino-4-methoxycarbonylbenzoic acid (1.95 g, 10 mmol) suspended in 3 M hydrochloric acid (12.5 mL) and acetic acid (20 mL), an aqueous solution (20 mL) of sodium nitrite (0.69 g, 10 mmol) was added at −10° C., and the resulting solution was stirred for 30 minutes. The solution was added to 10% aqueous sulfuric acid (30 mL) at 0° C., and the resulting reaction mixture was heated with reflux for 1 hour. The desired product was extracted with ethyl acetate, and the extract was dried over magnesium sulfate and purified by silica gel column chromatography to give 1.04 g of the desired product as a white solid (yield 53%).
1H-NMR (ppm in DMSO-6) δ 3.86 (s, 3H), 7.43 (d, J=8.1 Hz, 1H), 7.49 (s, 1H), 7.75 (d, J=8.1 Hz, 1H), 10.55 (brs, 1H). LC/MS (ESI) 196 (M+).
2) Synthesis of methyl 4-hydrazinocarbonyl-2-hydroxybenzoate
From 3-hydroxy-4-methoxycarbonylbenzoic acid, thionyl chloride and hydrazine monohydrate, 241 mg of the desired product was obtained in the same manner as in Reference Synthesis Example 39 as a while solid (yield 57%).
1H-NMR (ppm in DMSO-6) δ 3.90 (s, 3H), 4.55 (brs, 2H), 7.34 (dd, J=1.5, 8.1 Hz, 1H), 7.38 (d, J=1.5 Hz, 1H), 7.82 (d, J=8.1 Hz, 1H), 9.91 (brs, 1H), 10.52 (brs, 1H). LC/MS (ESI) 210 (M+).
Reference Synthetic Example 44
Synthesis of 2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-ethoxycarbonylthiophene
From 2-(3-trifluoromethylphenyl)-3-hydroxy-4-ethoxycarbonylthiophene (1.2 g, 3.9 mmol), the desired product was obtained in the same manner as in Reference Synthesis Example 16 as a brown oil (1.2 g, yield 88%).
1H-NMR (ppm in CDCl3) δ 1.36-1.42 (m, 3H), 3.19 (s, 3H), 4.33-4.37 (m, 2H), 5.05 (s, 2H), 7.53-7.56 (m, 2H), 7.83-7.85 (m, 1H), 8.02-8.07 (m, 2H). LC/MS (ES+) 383 (Na+ adduct).
Reference Synthetic Example 45
Synthesis of 2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-hydroxymethylthiophene
From 2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-ethoxycarbonylthiophene (1.2 g, 3.4 mmol), the desired product was obtained in the same manner as in Reference Synthesis Example 19 as a pale yellow oil (1.0 g, yield 95%).
1H-NMR (ppm in CDCl3) δ 3.50 (s, 3H), 4.57 (d, J=5.2 Hz, 2H), 4.91 (s, 2H), 7.23 (s, 1H), 7.48-7.56 (m, 2H), 7.80-7.82 (m, 1H), 7.96 (s, 1H). LC/MS (ES+) 341 (Na+ adduct).
Reference Synthetic Example 46
Synthesis of 2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-formylthiophene
From 2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-hydroxymethylthiophene (1.0 g, 3.2 mmol), the desired product was obtained in the same manner as in Reference Synthesis Example 24 as a brown oil (0.97 g, yield 96%).
1H-NMR (ppm in CDCl3) δ 3.29 (s, 3H), 5.03 (s, 2H), 7.53-7.62 (m, 2H), 7.83-8.06 (m, 3H), 9.91 (s, 1H). LC/MS (ES+) 339 (Na+ adduct).
Reference Synthetic Example 47
Synthesis of 2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-(1-hydroxyethyl)thiophene
From 2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-formylthiophene (0.97 g, 3.1 mmol), the desired product was obtained in the same manner as in Reference Synthesis Example 27 as a brown oil (0.97 g, yield 96%).
1H-NMR (ppm in CDCl3) δ 1.59-1.62 (m, 3H), 3.47 (s, 3H), 4.82-4.94 (m, 3H), 7.19 (s, 1H), 7.48-7.56 (m, 2H), 7.79-7.81 (m, 1H), 7.94 (s, 1H). LC/MS (ES+) 355 (Na+ adduct).
Reference Synthetic Example 48
Synthesis of 2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-methylcarbonylthiophene
From 2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-(1-hydroxyethyl)thiophene (0.99 g, 2.3 mmol), the desired product was obtained in the same manner as in Reference Synthesis Example 30 as a brown oil (0.76 g, yield 77%).
1H-NMR (ppm in CDCl3) δ 2.57 (s, 3H), 3.19 (s, 3H), 4.97 (s, 2H), 7.54-7.58 (m, 2H), 7.83-8.01 (m, 3H). LC/MS (ES+) 353 (Na+ adduct).
Reference Synthetic Example 49
Synthesis of 2-(3-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene
From 2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-methylcarbonylthiophene (0.76 g, 2.3 mmol), the desired product was obtained in the same manner as in Reference Synthesis Example 25 as a pale brown solid (0.59 g, yield 90%).
1H-NMR (ppm in CDCl3) δ 2.58 (s, 3H), 7.48-7.52 (m, 2H), 7.94-8.05 (m, 3H), 10.52 (s, 1H). LC/MS (ES+) 287.
Reference Synthetic Example 50
Synthesis of methyl 2-acetamino-4-hydrazinocarbonylbenzoate
1) Synthesis of 3-acetamino-4-methoxycarbonylbenzoic acid
Acetic anhydride (1.89 mL, 20 mmol) was added to a suspension of 3-amino-4-methoxycarbonylbenzoic acid (1.95 g, 10 mmol) in acetic acid (10 mL), and the mixture was heated with reflux for 6 hours. After cooling, the precipitated solid was filtered to obtain 2.12 g of the desired product as a colorless solid (yield 89%).
1H-NMR (ppm in DMSO-6) δ 2.13 (s, 3H), 3.87 (s, 3H), 7.71 (d, 1H, J=8.4 Hz), 7.96 (d, 1H, J=8.4 Hz), 8.68 (s, 1H), 10.51 (brs, 1H). LC/MS (ESI) 237 (M+).
2) Synthesis of methyl 2-acetamino-4-hydrazinocarbonylbenzoate
1-Hydroxybenzotriazole (HOBt) (270 mg, 2 mmol) and 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride (WSC) (498 mg, 2.6 mmol) were added to a solution of 3-acetamino-4-methoxycarbonylbenzoic acid (474 mg, 2 mmol) in dimethylformamide (10 mL), and the mixture was stirred at room temperature for 3 hours. Hydrazine monohydrate (485 μL, 10 mmol) was further added at 0° C., and the mixture was stirred overnight at room temperature. The precipitated solid was filtered, and then washed with water to obtain 400 mg of the desired product as a white solid (yield 80%).
1H-NMR (ppm in DMSO-d6) δ 2.12 (s, 3H), 3.85 (s, 3H), 4.55 (brs, 2H), 7.55 (d, 1H, J=8.1 Hz), 7.90 (d, 1H, J=8.1 Hz), 8.49 (s, 1H), 9.92 (brs, 1H), 10.48 (brs, 1H). LC/MS (ESI) 251 (M+).
Reference Synthetic Example 51
Synthesis of methyl 2-fluoro-4-hydrazinocarbonylbenzoate
1) Synthesis of methyl 4-bromo-2-fluorobenzoate
Methyl iodide (1.49 mL, 24 mmol) was added to a suspension of 4-bromo-2-fluorobenzoic acid (4.38 g, 20 mmol) and sodium carbonate (6.36 g, 60 mmol) in dimethylformamide (50 mL), and the mixture was stirred overnight at room temperature. After completion of the reaction, ethyl acetate was added, and the mixture was washed with water and a saturated ammonium chloride aqueous solution. After drying over magnesium sulfate, concentration was carried out to obtain 4.50 g of the desired product as a colorless solid (yield 97%).
1H-NMR (ppm in CDCl3) δ 3.93 (s, 3H), 7.33-7.38 (m, 2H), 7.80-7.85 (m, 1H).
2) Synthesis of methyl 4-benzyloxycarbonyl-2-fluorobenzoate
Palladium diacetate (4.5 mg, 0.02 mmol), 1,4-(bisdiphenylphosphino)butane (8.5 mg, 0.02 mmol), triethylamine (55.8 μL, 0.4 mmol) and benzyl alcohol (1 mL) were added to a solution of methyl 4-bromo-2-fluorobenzoate (46.6 mg, 0.2 mmol) in dimethylformamide (1 mL). In this solution, bubbling was carried out for a few minutes with carbon monoxide, and then this solution was heated at 120° C. for 12 hours under carbon monoxide atmosphere. After completion of the reaction, ethyl acetate was added, and the resultant product was washed with a saturated ammonium chloride aqueous solution, and purified with a silica gel column chromatography (hexane/ethyl acetate=19/1) to obtain 35.4 mg of the desired product as a yellow viscous liquid (yield 61%).
1H-NMR (ppm in CDCl3) δ 3.95 (s, 3H), 5.38 (s, 2H), 7.35-7.46 (m, 5H), 7.79-8.02 (m, 3H).
3) Synthesis of 3-fluoro-4-methoxycarbonylbenzoic acid
Catalytic amount of 10 wt % palladium carbon was added to a solution of methyl 4-benzyloxycarbonyl-2-fluorobenzoate (35.4 mg, 0.123 mmol) in ethanol (2 mL), and the mixture was stirred overnight at room temperature under hydrogen atmosphere. After completion of the reaction, the mixture was filtered through celite and the filtrate was concentrated to obtain 26.0 mg of the desired product as a colorless solid (yield 100%).
1H-NMR (ppm in CDCl3) δ 3.97 (s, 3H), 7.83-8.06 (m, 3H). LC/MS (ESI) 198 (M+).
4) Synthesis of methyl 2-fluoro-4-hydrazinocarbonylbenzoate
From 3-fluoro-4-methoxycarbonylbenzoic acid (198 mg, 1 mmol), 1-hydroxybenzotriazole (HOBt) (135 mg, 1 mmol), 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride (WSC) (249 mg, 1.3 mmol) and hydrazine monohydrate (73 μL, 1.5 mmol), 45.6 mg of the desired product was obtained in the same manner as in Reference Synthesis Example 50 as a white solid (yield 22%).
1H-NMR (ppm in DMSO-6) δ 3.87 (s, 3H), 4.60 (brs, 2H), 7.71-7.77 (m, 2H), 7.94-7.99 (m, 1H), 10.06 (brs, 1H). LC/MS (ESI) 212 (M+).
Reference Synthetic Example 52
Synthesis of 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-(1-hydroxyisobutyl)thiophene
To a solution of 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-formylthiophene (3.0 g, 10 mmol) in THF (2.5 mL), 2.0 M ethyl ether solution (6.0 mL, 12 mmol) of isopropylmagnesium bromide was added dropwise under cooling with ice, followed by stirring for 2.5 hours under cooling with ice. A saturated ammonium chloride aqueous solution was added to the reaction solution, and then extraction was carried out with ethyl acetate, and the organic layer was washed with a saturated sodium chloride solution and then dried over anhydrous sodium sulfate. The obtained organic layer was concentrated, and then purification was carried out with a silica gel column chromatography (n-hexane/ethyl acetate=3/1) to obtain the desired product as a pale yellow oil (1.18 g, yield 34%).
1H-NMR (ppm in CDCl3) δ 0.91 (d, J=6.6 Hz, 3H), 1.10 (d, J=6.6 Hz, 3H), 1.34 (s, 9H), 2.15-2.25 (m, 1H), 3.46 (s, 3H), 4.35 (d, J=8.0 Hz, 1H), 4.86 (s, 2H), 7.04 (s, 1H), 7.39 (d, J=8.8 Hz, 2H), 7.56 (d, J=8.8 Hz, 2H). LC/MS (ES−) 303.
Reference Synthetic Example 53
Synthesis of 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-isopropylcarbonylthiophene
Using 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-(1-hydroxyisobutyl)thiophene (1.07 g, 3.07 mmol) as the starting material, the desired product was obtained in the same manner as in Reference Synthetic Example 30 as a brown oil (0.85 g, yield 80%).
1H-NMR (ppm in CDCl3) δ 1.20 (s, 3H), 1.23 (s, 3H), 1.34 (s, 9H), 3.21 (s, 3H), 3.39-3.45 (m, 1H), 4.92 (s, 2H), 7.42 (d, J=8.7 Hz, 2H), 7.61 (d, J=8.7 Hz, 2H), 7.83 (s, 1H). LC/MS (ES+) 369 (Na+ adduct).
Reference Synthetic Example 54
Synthesis of 2-(4-t-butylphenyl)-3-hydroxy-4-isopropylcarbonylthiophene
Using 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-(isopropylcarbonyl)thiophene (0.85 g, 2.5 mmol) as the starting material, the desired product was obtained in the same manner as in Reference Synthetic Example 25 as a pale brown solid (0.42 g, yield 56%).
1H-NMR (ppm in CDCl3) δ 1.26 (s, 3H), 1.28 (s, 3H), 1.34 (s, 9H), 3.36-3.41 (m, 1H), 7.42 (d, J=8.8 Hz, 2H), 7.72 (d, J=8.8 Hz, 2H) 7.89 (s, 1H), 10.50 (s, 1H). LC/MS (ES+) 303.
Reference Synthetic Example 55
Synthesis of 2-bromo-5-(4-t-butylphenyl)-4-hydroxy-3-methylcarbonylthiophene
2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (2.66 g, 9.7 mmol), N-bromosuccinimide (1.73 g, 9.7 mmol) and benzoyl peroxide (153 mg, 0.63 mmol) were heated with reflux for 2 hours in 65 ml of chloroform. Water was added, and the reaction solution was extracted three times with chloroform, and the organic layer was washed with a saturated aqueous sodium chloride solution, and then dried over anhydrous sodium sulfate. The obtained organic layer was concentrated, and then purified with a silica gel column chromatography (n-hexane/chloroform=3/2) to obtain the desired product as a yellow solid (2.93 g, yield 86%).
1H-NMR (ppm in CDCl3) δ =1.33 (s, 9H), 2.79 (s, 3H), 7.39-7.43 (m, 2H), 7.62-7.66 (m, 2H), 10.91 (s, 1H). LC/MS (ES−) 351, 353.
Reference Synthetic Example 56
Synthesis of methyl 4-hydrazinocarbonothioylamino-2-nitrobenzoate
1) Synthesis of methyl 4-amino-2-nitrobenzoate
To a suspension of 4-amino-2-nitrobenzoic acid (200 mg, 1.10 mmol) synthesized in accordance with the synthesis method described in WO96/35666 and sodium carbonate (349 mg, 3.29 mmol) in dimethylformamide (5.5 mL), methyl iodide (0.21 ml) was added, and the mixture was stirred overnight at room temperature. Water was added to the reaction solution, and extraction was carried out with ethyl acetate, and the combined organic layer was washed with a saturated ammonium chloride aqueous solution and a saturated sodium chloride aqueous solution, followed by drying over anhydrous sodium sulfate. By concentrating the obtained organic layer, 216 mg of the desired product was obtained as a yellow solid (yield 100%).
1H-NMR (ppm in CDCl3) δ 7.69 (d, J=8.5 Hz, 1H), 6.85 (d, J=2.4 Hz, 1H), 6.77 (dd, J=2.4, 8.5 Hz, 1H), 4.31 (bs, 2H), 3.84 (s, 3H). LC/MS (ESI) 196.
2) Synthesis of 4-methoxycarbonyl-3-nitrophenyl isothiocyanate
A solution of the above synthesized methyl 4-amino-2-nitrobenzoate (50 mg, 0.25 mmol) and 1,1′-thiocarbonyldi-2(1H)-pyridone (59 mg, 0.25 mmol) in dichloromethane (4.2 ml) was stirred at room temperature for 3 hours. After completion of the reaction, the solvent was evaporated, followed by purification with a silica gel column chromatography to obtain 42 mg of the desired product as a colorless oil (yield 69%).
1H-NMR (ppm in CDCl3) δ 7.79 (d, J=8.3 Hz, 1H), 7.66 (d, J=2.1 Hz, 1H), 7.47 (dd, J=2.1, 8.3 Hz, 1H), 3.92 (s, 3H). LC/MS (ES−) 224 (M+—CH2).
3) Synthesis of methyl 4-hydrazinocarbonothioylamino-2-nitrobenzoate
A solution of the above synthesized 4-methoxycarbonyl-3-nitrophenyl isothiocyanate (149 mg, 0.62 mmol) in tetrahydrofuran (2.2 ml) was added dropwise to a solution of hydrazine monohydrate (94 mg, 1.87 mmol) in tetrahydrofuran (4.0 ml) at 0° C. over 20 minutes. After stirring at 0° C. for further 40 minutes, water was added, and the precipitated solid was filtered to obtain 142 mg of the desired product as a colorless solid (yield 85%).
1H-NMR (ppm in DMSO) δ 9.67 (bs, 1H), 8.71 (bs, 1H), 8.18-8.21 (m, 1H), 7.76-7.83 (m, 2H), 3.82 (s, 3H). LC/MS (ESI) 270.
Reference Synthetic Example 57
Synthesis of methyl 5-hydrazinocarbonothioylamino-2-thiophenecarboxylate
1) Synthesis of methyl 5-nitro-2-thiophenecarboxylate
From 5-nitrothiophene-2-carboxylic acid (3 g, 17.3 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 56 as a pale pink solid (2.97 g, yield 92%).
1H-NMR (ppm in CDCl3) δ 7.88 (d, J=4.3 Hz, 1H), 7.70 (d, J=4.3 Hz, 1H), 3.96 (s, 3H).
2) Synthesis of 5-methoxycarbonyl-2-thiophene isothiocyanate
To a solution of the above synthesized methyl 5-nitro-2-thiophenecarboxylate (2.67 g, 14.3 mmol) and iron (2.63 g, 47.1 mmol) in ethanol (50 ml) and water (9.9 ml), concentrated hydrochloric acid (0.12 ml, 1.43 mmol) was added at 90° C. And the mixture was stirred at 90° C. for 30 minutes. After completion of the reaction, 1 M sodium hydroxide aqueous solution (1.43 ml, 1.43 mmol) was added thereto. The insolubles were filtered off, and the filtrate was concentrated and extracted with ethyl acetate, then dried over anhydrous sodium sulfate. The obtained organic layer was concentrated and dried by means of a vacuum pump. From the resulting crude solid, the desired product was obtained in the same manner as in Reference Synthetic Example 56 as a pale yellow oil (904 mg, yield 32%).
1H-NMR (ppm in CDCl3) δ 7.56 (d, J=4.0 Hz, 1H), 6.83 (d, J=4.0 Hz, 1H), 3.88 (S, 3H). LC/MS (ES+) 199.
3) Synthesis of methyl 5-hydrazinocarbonothioylamino-2-thiophenecarboxylate
From the above synthesized methyl 5-methoxycarbonyl-2-thiophene isothiocyanate (484 mg, 2.43 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 56 as a colorless solid (435 mg, yield 77%).
1H-NMR (ppm in DMSO) δ 9.63 (bs, 1H), 7.55-7.57 (m, 1H), 7.12 (bs, 1H), 6.95 (bs, 1H), 3.76 (s, 3H). LC/MS (ESI) 231.
Reference Synthetic Example 58
Synthesis of methyl 4-hydrazinocarbonothioylamino-2-chlorobenzoate
1) Synthesis of methyl 4-amino-2-chlorobenzoate
From 4-amino-2-chlorobenzoic acid (500 mg, 2.91 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 56 as a pale brown solid (535 mg, yield 99%).
1H-NMR (ppm in CDCl3) δ 7.78 (d, J=8.5 Hz, 1H), 6.70 (d, J=2.2 Hz, 1H), 6.53 (dd, J=2.2 Hz, 8.5 Hz, 1H), 4.07 (bs, 2H), 3.86 (s, 3H). LC/MS (ES+) 185.
2) Synthesis of 4-methoxycarbonyl-3-chlorophenyl isothiocyanate
From the above synthesized methyl 4-amino-2-chlorobenzoate (505 mg, 2.72 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 56 as a colorless solid (424 mg, yield 69%).
1H-NMR (ppm in CDCl3) δ 7.87 (d, J=8.3 Hz, 1H), 7.31 (d, J=2.0 Hz, 1H), 7.15 (dd, J=2.0 Hz, 8.3 Hz, 1H), 3.93 (s, 3H). LC/MS (ES+) 227.
3) Synthesis of methyl 4-hydrazinocarbonothioylamino-2-chlorobenzoate
From the above synthesized 4-methoxycarbonyl-3-chlorophenyl isothiocyanate (420 mg, 1.85 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 56 as a colorless solid (364 mg, yield 76%).
1H-NMR (ppm in DMSO) δ 9.54 (bs, 1H), 8.24 (bs, 1H), 7.77-7.84 (m, 3H), 3.83 (s, 3H). LC/MS (ESI) 259.
Reference Synthetic Example 59-66
Table 15 shows the number of the synthetic examples (S.E.) obtained in the similar manner as described in the reference synthetic example (R.S.E.) 33, yields, shapes, LC/MS conditions (L.C.), LC/MS observed peaks (O.P.) and retention times (R.T.).












TABLE 15









yields

O.P.
R.T.













R.S.E.
(%)
shapes
L.C.
ESI+
ESI−
(min)





59
48
pale brown solid
2
297/299
295/297
4.54


60
73
yellow solid


61
83
yellow solid
9
303
301
3.34


62
93
brown solid
5
255
253
4.49


63
50
yellow solid
9
237
235
2.99


64
44
green solid
2
237
235
4.22


65
53
yellow solid
2
247
245
4.52


66
55
pale green solid
2
253/255
251/253
4.49









Reference Synthetic Example 67
Synthesis of 2-(3,4-dichlorophenyl)-4-(1-hydorazonoethyl)thiophen-3-ol
To a suspension of 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (300 mg, 1.05 mmol) in isopropanol (20 mL) was added hydrazine monohydrate (61 μL, 1.25 mmol). The reaction mixture was refluxed for 1.5 hours, stirred at room temperature for 0.5 hour and at 0° C. for 1 hour. The precipitated solid was collected by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (yield 100%).
1H-NMR (DMSO-d6) δ(ppm): 2.10(s, 3H), 6.63(br s, 2H), 7.58(s, 2H), 7.61 (s, 1H), 7.98 (s, 1H), 12.88(s, 1H). LC/MS: condition 8, retention time 4.95(min) LC/MS (ESI+)m/z; 301, 303 [M+1]+LC/MS (ESI−)m/z; 299, 301 [M−1]−
Reference Synthetic Example 68-75
Table 16 shows the number of the synthetic examples (S.E.) obtained in the similar manner as described in the reference synthetic example (R.S.E.) 67, yields, shapes, LC/MS conditions (L.C.), LC/MS observed peaks (O.P.) and retention times (R.T.).












TABLE 16









yields

O.P.
R.T.













R.S.E.
(%)
shapes
L.C.
ESI+
ESI−
(min)
















68
50
pale yellow solid
3
267/269
265/267
3.52


69
89
pale yellow solid
2
299
297
3.49


70
72
pale yellow solid


71
100
pale yellow solid


72
100
yellow solid
9
263
261
4.85


73
100
pale yellow solid
3
311/313
309/311
3.57


74
93
yellow solid
3
317
315
3.62


75
79
pale yellow solid
3
261
259
3.50









The structural formulae of the compounds obtained in the Reference Synthetic Example 59-75 are given below.













REFERENCE SYNTHETIC EX.59








 


REFERENCE SYNTHETIC EX.60








 


REFERENCE SYNTHETIC EX.61








 


REFERENCE SYNTHETIC EX.62








 


REFERENCE SYNTHETIC EX.63








 


REFERENCE SYNTHETIC EX.64








 


REFERENCE SYNTHETIC EX.65








 


REFERENCE SYNTHETIC EX.66








 


REFERENCE SYNTHETIC EX.67








 


REFERENCE SYNTHETIC EX.68








 


REFERENCE SYNTHETIC EX.69








 


REFERENCE SYNTHETIC EX.70








 


REFERENCE SYNTHETIC EX.71








 


REFERENCE SYNTHETIC EX.72








 


REFERENCE SYNTHETIC EX.73








 


REFERENCE SYNTHETIC EX.74








 


REFERENCE SYNTHETIC EX.75















Synthetic Example 1
Synthesis of 4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
1) Synthesis of 1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone
2-Oxopropanal methylhydrazone (1.525 mmol, 152.7 mg) synthesized in Reference Synthetic Example 1 and (3,4-dichlorophenyl)(oxo)acetaldehyde (1.525 mmol, 310 mg) synthesized in Reference Synthetic Example 3 were dissolved in acetic acid (10 mL) and stirred at 110° C. for 1.5 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump, resolved by silica gel thin layer chromatography (n-hexane/AcOEt=3/2) and purified by silica gel thin layer chromatography (n-hexane/AcOEt=2/1) to give the desired product as a yellow solid (57.8 mg, yield 13%).
1H-NMR (ppm in CDCl3) δ 8.25 (s, 1H), 7.58 (br.s, 1H), 7.55 (br.s, 1H), 7.33 (br.dd, 1H), 3.92 (s, 3H), 2.58 (s, 3H).
13C-NMR (ppm in CDCl3) δ 198.1, 143.8, 135.6, 133.2, 132.7, 130.9, 130.4, 127.8, 127.6, 125.8, 39.3, 25.6. LC-MS (ESI) 284 (M+).
2) Synthesis of 4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]methyl benzoate
1-[5-(3,4-Dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.1336 mmol, 38 mg), 4-hydrazinocarbonylmethyl benzoate (0.1336 mmol, 26 mg) and p-tosylic acid monohydrate (30 mol %, 6.9 mg) were dissolved in isopropyl alcohol (2.5 mL) and stirred at 100° C. for 3.5 hours. Then, the reactor was cooled to 0° C., and the precipitated solid was recovered by filtration and dried by means of a vacuum pump to give the desired product as a white solid (30.5 mg, yield 50%).
1H-NMR (ppm in DMSO-d6) δ 11.46 (s, 1H), 9.95 (s, 1H), 8.10 (ABq, J=8.3 Hz, 2H), 8.04 (ABq, J=8.3 Hz, 2H), 7.86 (d, J=2.0 Hz, 1H), 7.80 (d, J=8.3 Hz, 1H), 7.61 (dd, J=2.0, 8.3 Hz, 1H), 3.90 (s, 3H), 3.90 (s, 3H), 2.45 (s, 3H). LC-MS (ESI) 460 (M+).
3) Synthesis of 4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
To 4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]methyl benzoate (0.0518 mmol, 23.9 mg), methanol (3 mL) was added, and 1 M aqueous sodium hydroxide (0.259 mmol, 0.259 mL) was added at room temperature. After 20 minutes of stirring at room temperature and 2 hours of stirring at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (0.259 mmol, 0.259 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the desired product as a yellow solid (8.7 mg, yield 37%).
1H-NMR (ppm in DMSO-d6) δ 11.43 (s, 1H), 9.96 (s, 1H), 8.13-7.98 (multi, 4H), 7.86-7.78 (multi, 2H), 7.62-7.51 (multi, 1H), 3.90-3.87 (multi, 3H), 2.46-2.45 (multi, 3H). LC-MS (ESI) 446 (M+).
Synthetic Example 2
Synthesis of 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
1-[5-(3,4-Dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.139 mmol, 39.7 mg) synthesized in Synthetic Example 1 and 4-hydrazinocarbonothioylaminobenzoic acid (0.139 mmol, 29.4 mg) were stirred with dimethylformamide (4 mL) and two drops of concentrated hydrochloric acid at room temperature for 22 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting solid was stirred with chloroform/n-hexane for a while, then recovered by filtration and dried by means of a vacuum pump to give the desired product as a yellow solid (39.5 mg, yield 59%).
1H-NMR (ppm in DMSO-d6) δ 10.36 (s, 1H), 10.33 (s, 1H), 9.15 (s, 1H), 7.93 (ABq, J=8.6 Hz, 2H), 7.85-7.83 (multi, 2H), 7.79 (ABq, J=8.6 Hz, 2H), 7.58 (d, J=8.4 Hz, 1H), 3.85 (s, 3H), 2.39 (s, 3H). LC-MS (ESI) 477 (M+).
Synthetic Example 3
Synthesis of 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
1) Synthesis of 1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone
2-Oxopropanal methylhydrazone (46.375 mmol, 4.64 g) synthesized in Reference Synthetic Example 1 and (4-tert-butylphenyl)(oxo)acetaldehyde synthesized in Reference Synthetic Example 4 (46.375 mmol, 8.82 g) were dissolved in acetic acid (140 mL) and stirred at 100° C. for 2 hours. The reactor was cooled to room temperature, and after addition of water (100 mL) and saturated aqueous sodium chloride (50 mL), it was extracted with chloroform three times. The resulting organic layer was dried and filtered, and the solvent was evaporated. The residue was purified by silica gel column chromatography (n-hexane/ethyl acetate=4/1) to give the desired product as a yellow solid (5.79 g, yield 46%).
1H-NMR (ppm in CDCl3) δ 8.16 (s, 1H, exchangeable with D2O), 7.51 (ABq, J=8.4 Hz, 2H), 7.40 (ABq, J=8.4 Hz, 2H), 3.91 (s, 3H), 2.58 (s, 3H), 1.35 (s, 9H).
1H-NMR (ppm in DMSO-d6) δ 8.50 (s, 1H), 7.53 (ABq, J=8.6 Hz, 2H), 7.44 (ABq, J=8.6 Hz, 2H), 3.83 (s, 3H), 2.46 (s, 3H), 1.32 (s, 9H).
13C-NMR (ppm in CDCl3) δ 198.2, 151.6, 143.4, 135.6, 128.5, 128.3, 125.8, 124.7, 39.1, 34.7, 31.2, 25.6. LC-MS (ESI) 272 (M+).
2) Synthesis of 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]methyl benzoate
1-[5-(4-tert-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.441 mmol, 120.0 mg), 4-hydrazinocarbonylmethyl benzoate (0.441 mmol, 85.6 mg) and p-tosylic acid monohydrate (30 mol %, 22.8 mg) were dissolved in isopropyl alcohol (10 mL) and stirred at 100° C. for about 3 hours and then at 50° C. overnight. The reactor was cooled to 0° C., and the reaction solution was filtered and dried by means of a vacuum pump to give the desired product as a white solid (145.1 mg, yield 73%).
1H-NMR (ppm in CDCl3) δ 8.98 (s, 1H), 8.78 (br.s, 1H), 8.16-8.13 (multi, 2H), 7.92-7.80 (multi, 2H), 7.51-7.32 (multi, 4H), 3.95-3.88 (multi, 6H), 2.54 and 2.44 (sx2, 3H), 1.35 (s, 9H). LC-MS (ESI) 448 (M+).
3) Synthesis of 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
To 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]methyl benzoate (0.0816 mmol, 36.6 mg), methanol (2.5 mL) was added, and then 1 M aqueous sodium hydroxide (0.408 mmol. 0.408 mL) was added. After 22 hours of stirring at room temperature, 1 M hydrochloric acid (0.408 mmol, 0.408 mL) and water were added. The precipitated solid was recovered by filtration, washed with water, dried by means of a vacuum pump and purified by silica gel thin layer chromatography (chloroform/methanol=5/1) to give the desired product as a yellow solid (35.0 mg, yield 99%).
1H-NMR (ppm in DMSO-d6) δ 8.13-7.98 (multi, 4H), 7.59-7.43 (multi, 4H), 3.88 and 3.84 (sx2, 3H), 2.46 and 2.45 (sx2, 3H), 1.34 and 1.32 (sx2, 9H). LC-MS (ESI) 434 (M+).
Synthetic Example 4
Synthesis of 3-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonyl]methyl benzoate
1-[5-(4-tert-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.192 mmol, 52.2 mg) synthesized in Synthetic Example 3,3-hydrazinocarbonylmethyl benzoate (0.192 mmol, 37.2 mg) and p-tosylic acid monohydrate (30 mol %, 9.9 mg) were dissolved in isopropyl alcohol (7 mL) and stirred at 100° C. for about 15 hours. Then, the reactor was cooled to room temperature, and the reaction solution was filtered and dried by means of a vacuum pump to give the desired product as a white solid (65.3 mg, yield 76%).
1H-NMR (ppm in DMSO-d6) δ 11.42 (s, 1H), 9.70 (s, 1H), 8.47 (s, 1H), 8.19 (br.t, 2H), 7.71 (t, J=7.7 Hz, 1H), 7.55 (ABq, J=8.7 Hz, 2H), 7.51 (ABq, J=8.7 Hz, 2H), 3.92 (s, 3H), 3.85 (s, 3H), 2.46 (s, 3H), 1.34 (s, 9H). LC-MS (ESI) 448 (M+).
Synthetic Example 5
Synthesis of 3-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
To 3-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]methyl benzoate (0.119 mmol, 53.4 mg), methanol (2.5 mL) was added, and then 1 M aqueous sodium hydroxide (0.595 mmol, 0.595 mL) was added. After 1 hour of stirring at room temperature and 1 hour of stirring at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (0.595 mmol, 0.595 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting mixture was resolved by silica gel thin layer chromatography (CHCl3/MeOH=10/1) to give the desired product as a pale yellow solid (34 mg, yield 66%).
1H-NMR (ppm in DMSO-d6) δ 11.41 (s, 1H), 9.72 (s, 1H), 8.55 and 8.46 (sx2, 1H), 8.16-8.14 (multi, 2H), 7.71-7.63 (multi, 1H), 7.58-7.50 (multi, 4H), 3.94 and 3.85 (sx2, 3H), 2.46 (s, 3H), 1.34 (s, 9H). LC-MS (ESI) 434 (M+).
Synthetic Example 6
Synthesis of 4-{[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
1-[5-(4-tert-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.163 mmol, 44.4 mg) synthesized in Synthetic Example 3 and 4-hydrazinocarbonothioylaminobenzoic acid (0.163 mmol, 34.4 mg) were stirred with dimethylformamide (3 mL) and two drops of concentrated hydrochloric acid at room temperature for 20 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting solid was stirred with chloroform/n-hexane for a while, then recovered by filtration and dried by means of a vacuum pump to give the desired product as a yellow solid (37 mg, yield 48%).
1H-NMR (ppm in DMSO-d6) δ 10.88 (s, 1H), 10.34 (s, 1H), 8.86 (s, 1H), 7.95-7.84 (multi, 4H), 7.59-7.47 (multi, 4H), 3.83 and 3.81 (sx2, 3H), 2.46 and 2.39 (sx2, 3H), 1.34 and 1.33 (sx2, 9H). LC-MS (ESI) 465 (M+).
Synthetic Example 7
Synthesis of 4-{[(2-{1-[5-(4-tert-butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}benzoic acid
1) Synthesis of 1-[5-(4-tert-butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethanone
2-Oxopropanal ethylhydrazone (4.736 mmol, 540.6 mg) synthesized in Reference Synthetic Example 2 and (4-tert-butylphenyl)(oxo)acetaldehyde (4.736 mmol, 901.0 mg) synthesized in Reference Synthetic Example 4 were dissolved in acetic acid (20 mL) and stirred at 100° C. for about 3.5 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and purified by silica gel thin layer chromatography (n-hexane/AcOEt=1/2, 3/1 and 4/1) to give the desired product as an orange liquid(212 mg, yield 16%).
1H-NMR (ppm in CDCl3) δ 8.12 (s, 1H), 7.50 (ABq, J=8.6 Hz, 2H), 7.36 (ABq, J=8.6 Hz, 2H), 4.19 (q, J=7.2 Hz, 2H), 2.59 (s, 3H), 1.42 (t, J=7.2 Hz, 3H), 1.36 (s, 9H). LC-MS (ESI) 286 (M+).
2) Synthesis of 4-{[(2-{1-[5-(4-tert-butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}benzoic acid
1-[5-(4-tert-Butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethanone (0.1718 mmol, 49.2 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.1718 mmol, 36.3 mg) were stirred with dimethylformamide (3 mL) and two drops of concentrated hydrochloric acid at room temperature for 21 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting solid was stirred with chloroform/n-hexane for a while, then recovered by filtration and dried by means of a vacuum pump to give the desired product as a yellow solid (59 mg, yield 72%).
1H-NMR (ppm in DMSO-d6) δ 10.89 (s, 1H), 10.33 (s, 1H), 8.77 (s, 1H), 7.94-7.84 (multi, 4H), 7.60-7.41 (multi, 4H), 4.08 (q, J=7.2 Hz, 2H), 2.47 and 2.41 (sx2, 3H), 1.34 and 1.33 (sx2, 9H), 1.27 (t, J=7.2 Hz, 3H). LC-MS (ESI) 479 (M+).
Synthetic Example 8
Synthesis of 4-{[(2-{1-[5-(4-tert-butylphenyl)-1-benzyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}benzoic acid
1) Synthesis of 1-[5-(4-tert-butylphenyl)-1-benzyl-4-hydroxy-1H-pyrazol-3-yl]ethanone
2-Oxopropanal benzylhydrazone (2.314 mmol, 408 mg) synthesized in the same manner as in Reference Synthetic Examples 1 and 2 and (4-tert-butylphenyl)(oxo)acetaldehyde (1.929 mmol, 366.9 mg) synthesized in Reference Synthetic Example 4 were dissolved in acetic acid (9 mL) and stirred at 100° C. for about 6 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and purified by silica gel column chromatography (n-hexane/AcOEt=3/1, and 4/1) to give the desired product as a yellow solid (74.1 mg, yield 11%).
1H-NMR (ppm in CDCl3) δ 8.15 (s, 1H), 7.43-7.40 (multi, 2H), 7.30-7.25 (multi, 5H), 7.06-7.03 (multi, 2H), 5.34 (s, 2H), 2.60 (s, 3H), 1.32 (s, 9H). LC-MS (ESI) 348 (M+).
2) Synthesis of 4-{[(2-{1-[5-(4-tert-butylphenyl)-1-benzyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
1-[5-(4-tert-Butylphenyl)-1-benzyl-4-hydroxy-1H-pyrazol-3-yl]ethanone (0.218 mmol, 76 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.218 mmol, 46 mg) were stirred with dimethylformamide (3.5 mL) and three drops of concentrated hydrochloric acid at room temperature for 22 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting solid was stirred with chloroform/n-hexane for a while, then recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (83 mg, yield 70%).
1H-NMR (ppm in DMSO-d6) δ 10.94 (br.s, 1H), 10.36-10.34 (br.s, 1H), 8.90 (s, 1H), 7.94-7.85 (multi, 4H), 7.56-7.47 (multi, 2H), 7.39-7.21 (multi, 5H), 7.09-6.95 (multi, 2H), 5.34 and 5.29 (sx2, 2H), 2.47 and 2.40 (sx2, 3H), 1.33 and 1.30 (sx2, 9H). LC-MS (ESI) 541 (M+).
Synthetic Example 9
Synthesis of 4-{[(2-{1-[5-(3,4-dimethylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
1) Synthesis of 1-[5-(3,4-dimethylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethanone
2-Oxopropanal methylhydrazone (8.18 mmol, 819 mg) synthesized in Reference Synthetic Example 1 and (3,4-dimethylphenyl)(oxo)acetaldehyde (7.57 mmol, 1.227 g) synthesized in Reference Synthetic Example 5 were dissolved in acetic acid (30 mL) and stirred at 100° C. for about 5 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and subjected to silica gel column chromatography (n-hexane/AcOEt=2/1, and 4/1) to give the crude product. The crude product was stirred with CHCl3/n-hexane for a while, and then recovered by filtration. The filtered solid was combined with a solid obtained by silica gel thin layer chromatography purification (n-hexane/AcOEt=4/1) of the filtrate to give the desired product as an orange solid (237.5 mg, yield 13%).
1H-NMR (ppm in CDCl3) δ 8.13 (br.s, 1H), 7.23-7.15 (multi, 3H), 3.88 (s, 3H), 2.58 (s, 3H), 2.34-2.31 (multi, 6H). LC-MS (ESI) 244 (M+).
2) Synthesis of 4-{[(2-{1-[5-(3,4-dimethylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
1-[5-(3,4-Dimethylphenyl)-i-methyl-4-hydroxy-1H-pyrazol-3-yl]ethanone (0.2423 mmol, HPLC purity 84.3%, 70.2 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.2423 mmol, 51.2 mg) were stirred with dimethylformamide (3 mL) and three drops of concentrated hydrochloric acid at room temperature for 8.5 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting solid was stirred with chloroform/n-hexane for a while, then recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (72.3 mg, yield 68%).
1H-NMR (ppm in DMSO-d6) δ 10.84 (br.s, 1H), 10.33 (s, 1H), 8.82 and 8.32 (sx2, 1H), 7.94-7.83 (multi, 4H), 7.32-7.23 (multi, 3H), 3.81 and 3.79 (sx2, 3H), 2.46 and 2.39 (sx2, 3H), 2.30-2.29 (multi, 6H). LC-MS (ESI) 437 (M+).
Synthetic Example 10
Synthesis of 4-{[(2-{1-[5-(4-n-pentylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
1) Synthesis of 1-[5-(4-n-pentylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethanone
2-Oxopropanal methylhydrazone (8.6 mmol, 861 mg) synthesized in Reference Synthetic Example 1 and (4-n-pentylphenyl)(oxo)acetaldehyde (8.6 mmol, 1.757 g) synthesized in Reference Synthetic Example 6 were dissolved in acetic acid (30 mL) and stirred at 100° C. for about 5 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and purified by silica gel column chromatography (n-hexane/AcOEt=2/1, and 4/1) to give the desired product as an orange solid (252.5 mg, yield 10.3%, crude).
1H-NMR (ppm in CDCl3) δ 8.16 (br.s, 1H), 7.37 (ABq, J=8.3 Hz, 2H), 7.29 (ABq, J=8.3 Hz, 2H), 3.90 (s, 3H), 2.70-2.62 (multi, 2H), 2.58 (S, 3H), 1.70-1.60 (multi, 2H), 1.39-1.32 (multi, 4H), 0.93-0.87 (multi, 3H). LC-MS (ESI) 286 (M+).
2) Synthesis of 4-{[(2-{1-[5-(4-n-pentylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
1-[5-(4-n-Pentylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethanone (0.2381 mmol, HPLC purity 86.3%, 79.0 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.2381 mmol, 50.3 mg) were stirred with dimethylformamide (3 mL) and three drops of concentrated hydrochloric acid at room temperature for 8.5 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting solid was stirred with chloroform/n-hexane for a while, then recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (86.4 mg, yield 76%).
1H-NMR (ppm in DMSO-d6) δ 10.90 (br.s, 1H), 10.34 (s, 1H), 8.85 (s, 1H), 7.94-7.84 (multi, 4H), 7.48-7.32 (multi, 4H), 3.82 and 3.80 (sx2, 3H), 2.65-2.60 (multi, 2H), 2.46 and 2.39 (sx2, 3H), 1.64-1.57 (multi, 2H), 1.34-1.30 (multi, 4H), 0.90-0.86 (multi, 3H). LC-MS (ESI) 479 (M+).
Synthetic Example 11
Synthesis of 4-{[(2-{1-[5-(4-trifluoromethylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
1) Synthesis of 1-[5-(4-trifluoromethylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethanone
2-Oxopropanal methylhydrazone (8.540 mmol, 855 mg) synthesized in Reference Synthetic Example 1 and (4-trifluoromethylphenyl)(oxo)acetaldehyde (6.432 mmol, 1.3 g) synthesized in Reference Synthetic Example 7 were dissolved in acetic acid (30 mL) and stirred at 100° C. for about 5 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and purified by silica gel column chromatography (n-hexane/AcOEt=2/1, and 4/1) to give the desired product as an orange solid (157.3 mg, yield 8.6%).
1H-NMR (ppm in CDCl3) δ 8.28 (s, 1H), 7.75 (ABq, J=8.3 Hz, 2H), 7.62 (ABq, J=8.3 Hz, 2H), 3.95 (s, 3H), 2.59 (s, 3H). LC-MS (ESI) 284 (M+).
2) Synthesis of 4-{[(2-{1-[5-(4-trifluoromethylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
1-[5-(4-trifluoromethylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethanone (0.1694 mmol, HPLC purity 80%, 60.2 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.1694 mmol, 35.8 mg) were stirred with dimethylformamide (3 mL) and three drops of concentrated hydrochloric acid at room temperature for 8.5 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. Chloroform/n-hexane was added to the resulting solid, and the precipitated solid was recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (72.2 mg, yield 89%).
1H-NMR (ppm in DMSO-d6) δ 10.93 (br.s, 1H), 10.36 and 10.35 (br.sx2, 1H), 9.14 (s, 1H), 7.95-7.80 (multi, 8H), 3.88 (s, 3H), 2.47 and 2.41 (sx2, 3H). LC-MS (ESI) 477 (M+).
Synthetic Example 12
Synthesis of 4-[(2-{1-[5-(3,4-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonyl]benzoic acid
1) Synthesis of methyl 4-[(2-{1-[5-(3,4-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate
1-[5-(3,4-Dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.365 mmol, 105.8 mg), 4-hydrazinocarbonylmethyl benzoate (0.365 mmol, 70.9 mg) and p-tosylic acid monohydrate (30 mol %, 18.9 mg) were dissolved in isopropyl alcohol (12 mL) and stirred at 100° C. for about 19 hours. The reactor was cooled to room temperature, and the precipitated solid was recovered by filtration, dried by means of a vacuum pump and purified by silica gel thin layer chromatography (chloroform/methanol=10/1) to give the desired product as a white solid (21.7 mg, yield 14%).
1H-NMR (ppm in DMSO-d6) δ 11.39 (br.s, 1H), 9.66 (br.s, 1H), 8.10 (ABq, J=8.3 Hz, 2H), 8.04 (ABq, J=8.3 Hz, 2H), 7.34 (br.s, 1H), 7.28 (br.s, 2H), 3.90 (s, 3H), 3.83 (s, 3H), 2.45 (s, 3H), 2.30 (s, 3H), 2.28 (s, 3H). LC-MS (ESI) 420 (M+).
2) Synthesis of 4-[(2-{1-[5-(3,4-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
To methyl 4-[(2-{1-[5-(3,4-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate (0.051 mmol,
21.6 mg), methanol (2.0 mL) was added, and 1 M aqueous sodium hydroxide (5 eq., 0.257 mL) was added at room temperature. After 30 minutes of stirring at room temperature and 1.5 hours of stirring at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (5 eq., 0.257 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the desired product as a yellow solid (17.5 mg, yield 84%).
1H-NMR (ppm in DMSO-d6) δ 11.35 (br.s, 1H), 9.69 (br.s, 1H), 8.07-7.96 (multi, 4H), 7.88-7.26 (multi, 3H), 3.82 (s, 3H), 2.45 (s, 3H), 2.30 (s, 3H), 2.28 (s, 3H). LC-MS (ESI) 406 (M+).
Synthetic Example 13
Synthesis of 4-[(2-{1-[4-hydroxy-1-methyl-5-(4-n-pentylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
1) Synthesis of methyl 4-[(2-{1-[4-hydroxy-1-methyl-5-(4-n-pentylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate
1-[4-Hydroxy-1-methyl-5-(4-n-pentylphenyl)-1H-pyrazol-3-yl]ethanone (0.309 mmol, 102.4 mg), 4-hydrazinocarbonylmethyl benzoate (0.309 mmol, 59.9 mg) and p-tosylic acid monohydrate (30 mol %, 15.9 mg) were dissolved in isopropyl alcohol (12 mL) and stirred at 100° C. for about 20 hours. The reactor was cooled to room temperature, and the precipitated solid was recovered by filtration and dried by means of a vacuum pump to give the desired product as a white solid (87.9 mg, yield 62%).
1H-NMR (ppm in DMSO-d6) δ 11.27 (br.s, 1H), 9.94 (br.s, 1H), 8.10-8.05 (multi, is 4H), 7.48 (ABq, J=8.1 Hz, 2H), 7.34 (ABq, J=8.1 Hz, 2H), 3.90 (s, 3H), 3.84 (s, 3H), 2.63 (t, J=7.1 Hz, 2H), 2.44 (s, 3H), 1.62 (multi, 2H), 1.33-1.32 (multi, 4H), 0.88 (t, J=7.1 Hz, 3H). LC-MS (ESI) 462 (M+).
2) Synthesis of 4-[(2-{1-[4-hydroxy-1-methyl-5-(4-n-pentylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
To methyl 4-[(2-{1-[4-hydroxy-1-methyl-5-(4-n-pentylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate (0.121 mmol, 66.5 mg), methanol (3.5 mL) was added, and 1 M aqueous sodium hydroxide (5 eq., 0.605 mL) was added at room temperature. After 30 minutes of stirring at room temperature and 1.5 hours of stirring at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (5 eq., 0.605 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the desired product as a yellow solid (40.4 mg, yield 74%).
1H-NMR (ppm in DMSO-d6) δ 11.36 (br.s, 1H), 9.69 (br.s, 1H), 8.07 (ABq, J=8.3 Hz, 2H), 8.01 (ABq, J=8.3 Hz, 2H), 7.48 (ABq, J=8.0 Hz, 2H), 7.34 (ABq, J=8.0 Hz, 2H), 3.84 (s, 3H), 2.63 (t, J=7.7 Hz, 2H), 2.45 (s, 3H), 1.62 (multi, 2H), 1.33-1.32 (multi, 4H), 0.88 (t, J=6.8 Hz, 3H). LC-MS (ESI) 448 (M+).
Synthetic Example 14
Synthesis of 4-{[2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}benzoic acid
1) Synthesis of methyl 4-{[2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}benzoate
1-[4-Hydroxy-1-methyl-5-(4-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethanone (0.231 mmol, 82.1 mg), 4-hydrazinocarbonylmethyl benzoate (0.231 mmol, 44.9 mg) and p-tosylic acid monohydrate (30 mol %, 11.9 mg) were dissolved in isopropyl alcohol (12 mL) and stirred at 100° C. for about 20 hours. The reactor was cooled to room temperature, and the precipitated solid was recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (66.5 mg, yield 63%).
1H-NMR (ppm in DMSO-d6) δ 11.46 (br.s, 1H), 9.97 (br.s, 1H), 8.11 (ABq, J=8.6 Hz, 2H), 8.04 (ABq, J=8.6 Hz, 2H), 7.89 (ABq, J=8.6 Hz, 2H), 7.84 (ABq, J=8.6 Hz, 2H), 3.92 (s, 3H), 3.90 (s, 3H), 2.47 (s, 3H). LC-MS (ESI) 460 (M+).
2) Synthesis of 4-{[2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}benzoic acid
To methyl 4-{[2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}benzoate (0.116 mmol, 53.4 mg), methanol (2 mL) was added, and 1 M aqueous sodium hydroxide (5 eq., 0.580 mL) was added at room temperature. After 30 minutes of stirring at room temperature and 1 hour of stirring at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (5 eq., 0.580 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the desired product as a yellow solid (37.7 mg, yield 73%).
1H-NMR (ppm in DMSO-d6) δ 11.43 (br.s, 1H), 9.98 (br.s, 1H), 8.07 (ABq, J=8.4 Hz, 2H), 8.01 (ABq, J=8.4 Hz, 2H), 7.89 (ABq, J=8.3 Hz, 2H), 7.84 (ABq, J=8.3 Hz, 2H), 3.92 (s, 3H), 2.47 and 2.42 (sx2, 3H). LC-MS (ESI) 446 (M+).
Synthetic Example 15
Synthesis of 4-{[2-(1-{4-hydroxy-1-methyl-5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}benzoic acid
1) Synthesis of 1-[4-hydroxy-1-methyl-5-(3-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethanone
2-Oxopropanal methylhydrazone (7.49 mmol, 750 mg) and (oxo) [3-trifluoromethylphenyl]acetaldehyde (7.0 mmol, 1.42 g) synthesized in Reference Synthetic Example 8 were dissolved in acetic acid (20 mL) and stirred at 100° C. for 4 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and purified by silica gel column chromatography (n-hexane/ethyl acetate=2/1) and then by silica gel thin layer chromatography (chloroform/methanol=30/1) to give the desired product as a reddish yellow liquid (221 mg, yield 11%).
1H-NMR (ppm in CDCl3) δ 8.26 (s, 1H), 7.70-7.60 (multi, 4H), 3.93 (s, 3H), 2.59 (s, 3H). LC-MS (ESI) 284 (M+).
2) Synthesis of methyl 4-{[2-(1-{4-hydroxy-1-methyl-5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}benzoate
1-[4-Hydroxy-1-methyl-5-(3-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethanone (0.502 mmol, 142.7 mg), 4-hydrazinocarbonylmethyl benzoate (0.502 mmol, 97.5 mg) and p-tosylic acid monohydrate (30 mol %, 26.0 mg) were dissolved in isopropyl alcohol (13 mL) and stirred at 100° C. for about 11 hours. The reactor was cooled to room temperature, and the precipitated solid was recovered by filtration, dried by means of a vacuum pump and purified by silica gel thin layer chromatography (chloroform/methanol=10/1) and then by silica gel thin layer chromatography (n-hexane/ethyl acetate=1/2) to give the desired product as a yellow solid (36.7 mg, yield 16%).
1H-NMR (ppm in DMSO-d6) δ 11.46 (br.s, 1H), 9.94 (br.s, 1H), 8.10 (ABq, J=8.1 Hz, 2H), 8.05 (ABq, J=8.1 Hz, 2H), 7.95-7.90 (multi, 2H), 7.81-7.77 (multi, 2H), 3.91 (br.s, 6H), 2.47 (s, 3H). LC-MS (ESI) 460 (M+).
3) Synthesis of 4-{[2-(1-{4-hydroxy-1-methyl-5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}benzoic acid
To methyl 4-{[2-(1-{4-hydroxy-1-methyl-5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}benzoate (0.072 mmol, 33.1 mg), methanol (2 mL) was added, and 1 M aqueous sodium hydroxide (5 eq., 0.360 mL) was added at room temperature. After 30 minutes of stirring at room temperature and 1.5 hours of stirring at 60° C., the reactor was cooled to 0° C., and 1 M hydrochloric acid (5 eq., 0.360 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the desired product as a yellow solid (17.6 mg, yield 55%).
1H-NMR (ppm in DMSO-d6) δ 11.40 (br.s, 1H), 9.99 (br.s, 1H), 8.06-7.69 (multi, 8H), 3.91 and 3.89 (br.sx2, 3H), 2.47 and 2.39 (br.sx2, 3H). LC-MS (ESI) 446 (M+).
Synthetic Example 16
Synthesis of 4-[(2-{1-[5-(3,5-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
1) Synthesis of 1-[5-(3,5-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone
2-Oxopropanal methylhydrazone (7.29 mmol, 730 mg) and (3,5-dimethylphenyl)(oxo)acetaldehyde (7.29 mmol, 1.18 g) synthesized in Reference Synthetic Example 10 were dissolved in acetic acid (25 mL) and stirred at 100° C. for 5 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and purified by silica gel column chromatography (n-hexane/ethyl acetate=3/1) and then by silica gel thin layer chromatography (n-hexane/ethyl acetate=3/1) to give the desired product as an orange liquid (93 mg, yield 5%).
1H-NMR (ppm in CDCl3) δ 8.15 (s, 1H), 7.05 (br.s, 3H), 3.88 (s, 3H), 2.58 (s, 3H), 2.37 (s, 6H). LC-MS (ESI) 244 (M+).
2) Synthesis of methyl 4-[(2-{1-[5-(3,5-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate
1-[5-(3,5-Dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.120 mmol, 29.3 mg) and 4-hydrazinocarbonylmethyl benzoate (0.120 mmol, 23.3 mg) were dissolved in dimethylformamide (5 mL) and stirred at 110° C. for 23 hours. Then, the reactor was cooled to room temperature, and the solvent was evaporated with a centrifugal evaporator. The residue was dried and purified by silica gel thin layer chromatography (chloroform/methanol=10/1) to give the desired product as a yellow solid (23.4 mg, yield 46%). LC-MS (ESI) 420 (M+).
3) Synthesis of 4-[(2-{1-[5-(3,5-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
To methyl 4-[(2-{1-[5-(3,5-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate (0.015 mmol, 6.5 mg), methanol (1 mL) was added, and 1 M aqueous sodium hydroxide (5 eq., 0.077 mL) was added at room temperature. After 20 minutes of stirring at room temperature and 1.5 hours of stirring at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (5 eq., 0.077 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump, and the residue was further purified by silica gel thin layer chromatography (chloroform/methanol=10/1). After addition of chloroform/n-hexane, the precipitated solid was recovered by filtration and dried to give the desired product as a yellow solid (1.7 mg, yield 27%). LC-MS (MSI) 406 (M+).
Synthetic Example 17
Synthesis of 4-[(2-{1-[4-hydroxy-5-(4-isopropylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
1) Synthesis of 1-[5-(4-isopropylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone
2-Oxopropanal methylhydrazone (10.44 mmol, 1.05 g) and (4-isopropylphenyl)(oxo)acetaldehyde (10.44 mmol, 1.84 g) synthesized in Reference Synthetic Example 12 were dissolved in acetic acid (37 mL) and stirred at 100° C. for 4.5 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and purified by silica gel column chromatography (n-hexane/ethyl acetate=3/1) and then by silica gel thin layer chromatography (n-hexane/ethyl acetate=3/1) to give the desired product as an orange solid (113 mg, yield 4%).
1H-NMR (ppm in CDCl3) δ 8.15 (s, 1H), 7.39 (ABq, J=8.3 Hz, 2H), 7.34 (ABq, J=8.3 Hz, 2H), 3.90 (s, 3H), 2.96 (sept, J=6.9 Hz, 1H), 2.58 (s, 3H), 1.28 (d, J=6.9 Hz, 6H). LC-MS (ESI) 258 (M+).
2) Synthesis of methyl 4-[(2-{1-[4-hydroxy-5-(4-isopropylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate
1-[5-(4-Isopropylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.170 mmol, 44.0 mg) and 4-hydrazinocarbonylmethyl benzoate (0.170 mmol, 33.1 mg) were dissolved in dimethylformamide (5.5 mL) and stirred at 110° C. for 23 hours. Then, the reactor was cooled to room temperature, and the solvent was evaporated with a centrifugal evaporator. The residue was dried, and chloroform was added. The precipitated solid was recovered by filtration to give the desired product as a yellow solid (39.1 mg, yield 53%). LC-MS (ESI) 434 (M+).
3) Synthesis of 4-[(2-{1-[4-hydroxy-5-(4-isopropylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
To methyl 4-[(2-{1-[4-hydroxy-5-(4-isopropylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate (0.037 mmol, 16.0 mg), methanol (3 mL) was added, and 1 M aqueous sodium hydroxide (5 eq., 0.184 mL) was added at room temperature. After 15 minutes of stirring at room temperature and 1.5 hours of stirring at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (5 eq., 0.184 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump, and the residue was further purified by silica gel thin layer chromatography (chloroform/methanol=10/1). After addition of chloroform/n-hexane, the precipitated solid was dried to give the desired product as a yellow solid (6.8 mg, yield 44%).
1H-NMR (ppm in DMSO-d6) δ 11.33 (br.s, 1H), 9.70 (br.s, 1H), 8.09-7.93 (multi, 4H), 7.51-7.38 (multi, 4H), 3.86 and 3.84 (sx2, 3H), 2.99-2.94 (multi, 1H), 2.45 and 2.43 (sx2, 3H), 1.26 (d, J=6.9 Hz, 6H). LC-MS (ESI) 420 (M+).
Synthetic Example 18
Synthesis of 4-[(2-{1-[4-hydroxy-5-(4-isobutylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
1) Synthesis of 1-[4-hydroxy-5-(4-isobutylphenyl)-1-methyl-1H-pyrazol-3-yl]ethanone
2-Oxopropanal methylhydrazone (11.60 mmol, 1.16 g) and (4-isobutylphenyl)(oxo)acetaldehyde (11.60 mmol, 2.21 g) synthesized in Reference Synthetic Example 15 were dissolved in acetic acid (38 mL) and stirred at 100° C. for 4.5 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and purified by silica gel column chromatography (n-hexane/ethyl acetate=3/1), then by silica gel thin layer chromatography (chloroform) and by silica gel thin layer chromatography (n-hexane/ethyl acetate=3/1) to give the desired product as a brown solid (154 mg, yield 5%).
1H-NMR (ppm in CDCl3) δ 8.17 (s, 1H), 7.37 (ABq, J=8.3 Hz, 2H), 7.26 (ABq, J=8.3 Hz, 2H), 3.90 (s, 3H), 2.58 (s, 3H), 2.52 (d, J=6.9 Hz, 2H), 1.91 (sept, J=6.9 Hz, 1H), 0.94 (d, J=6.9 Hz, is 6H). LC-MS (ESI) 272 (M+).
2) Synthesis of methyl 4-[(2-{1-[4-hydroxy-5-(4-isobutylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate
1-[4-Hydroxy-5-(4-isobutylphenyl)-1-methyl-1H-pyrazol-3-yl]ethanone (0.353 mmol, 96.0 mg) and 4-hydrazinocarbonylmethyl benzoate (0.353 mmol, 68.5 mg) were dissolved in dimethylformamide (7 mL) and stirred at 110° C. for 23 hours. Then, the reactor was cooled to room temperature, and the solvent was evaporated with a centrifugal evaporator. The residue was dried, and chloroform was added. The precipitated solid was recovered by filtration to give the desired product as a yellow solid (93.2 mg, yield 59%).
LC-MS (ESI) 448 (M+).
3) Synthesis of 4-[(2-{1-[4-hydroxy-5-(4-isobutylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
To methyl 4-[(2-{1-[4-hydroxy-5-(4-isobutylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate (0.129 mmol, 57.7 mg), methanol (2.5 mL) was added, and 1 M aqueous sodium hydroxide (5 eq., 0.643 mL) was added at room temperature. After 15 minutes of stirring at room temperature and 1.5 hours of stirring at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (5 eq., 0.643 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump, and the residue was further purified by silica gel thin layer chromatography (chloroform/methanol=10/1). After addition of chloroform/n-hexane, the precipitated solid was dried to give the desired product as a yellow solid (25.6 mg, yield 46%).
1H-NMR (ppm in DMSO-d6) δ 11.34 (s, 1H), 9.72 (s, 1H), 8.10-7.95 (multi, 4H), 7.S0-7.46 (multi, 2H), 7.34-7.30 (multi, 2H), 3.87 and 3.84 (sx2, 3H), 2.45 (s, 3H), 1.90 (sept, J=6.8 Hz, 1H), 0.91 (d, J=6.8 Hz, 6H). LC-MS (ESI) 434 (M+).
Synthetic Example 19
Synthesis of 4-[(2-{1-[5-(3-bromo-4-fluorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
1) Synthesis of 1-[5-(3-bromo-4-fluorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone
2-Oxopropanal methylhydrazone (10.56 mmol, 1.06 g) and (3-bromo-4-fluorophenyl)(oxo)acetaldehyde (10.56 mmol, 2.44 g) synthesized in Reference Synthetic Example 9 were dissolved in acetic acid (37 mL) and stirred at 100° C. for 4.5 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and purified by silica gel column chromatography (n-hexane/ethyl acetate=3/1), then by silica gel thin layer chromatography (chloroform) and by silica gel thin layer chromatography (n-hexane/ethyl acetate=3/1) to give the desired product as a brown solid (160 mg, yield 5%).
1H-NMR (ppm in CDCl3) δ 8.21 (s, 1H), 7.69-7.66 (multi, 1H), 7.41-7.37 (multi, 1H), 7.27-7.22 (multi, 1H), 3.89 (s, 3H), 2.58 (s, 3H). LC-MS (ESI) 312, 314 (M+).
2) Synthesis of methyl 4-[(2-{1-[5-(3-bromo-4-fluorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate
1-[5-(3-Bromo-4-fluorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.269 mmol, 84.1 mg) and 4-hydrazinocarbonylmethyl benzoate (0.269 mmol, 52.2 mg) were dissolved in dimethylformamide (7 mL) and stirred at 110° C. for 23 hours. Then, the reactor was cooled to room temperature, and the solvent was evaporated with a centrifugal evaporator. The residue was dried, and chloroform was added. The precipitated solid was recovered by filtration to give the desired product as a yellow solid (60.1 mg, yield 46%).
LC-MS (ESI) 488 (M+).
3) Synthesis of 4-[(2-{1-[5-(3-bromo-4-fluorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
To methyl 4-[(2-{1-[5-(3-bromo-4-fluorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate (0.051 mmol, 24.9 mg), methanol (2.5 mL) was added, and 1 M aqueous sodium hydroxide (5 eq., 0.255 mL) was added at room temperature. After 10 minutes of stirring at room temperature and 1.5 hours of stirring at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (5 eq., 0.255 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump, and the residue was further purified by silica gel thin layer chromatography (chloroform/methanol=10/1). After addition of chloroform/n-hexane, the precipitated solid was dried to give the desired product as a yellow solid (9.0 mg, yield 37%).
1H-NMR (ppm in DMSO-d6) δ 11.40 (s, 1H), 9.87 (s, 1H), 8.12-7.91 (multi, 5H), 7.62-7.52 (multi, 2H), 3.86 (s, 3H), 2.45 and 2.43 (sx2, 3H). LC-MS (ESI) 474 (M+).
Synthetic Example 20
Synthesis of 4-[(2-{1-[5-(4-ethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
1) Synthesis of 1-[5-(4-ethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone
2-Oxopropanal methylhydrazone (13.7 mmol, 1.37 g) and (4-ethylphenyl)(oxo)acetaldehyde (13.5 mmol, 2.19 g) synthesized in Reference Synthetic Example 11 were dissolved in-acetic acid (30 mL) and stirred at 100° C. for 6 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and purified by silica gel column chromatography (n-hexane/ethyl acetate=3/1), then by silica gel thin layer chromatography (chloroform) and by silica gel thin layer chromatography (n-hexane/ethyl acetate=7/2) to give the desired product as a brown solid (255 mg, yield 8%).
1H-NMR (ppm in CDCl3) δ 8.15 (s, 1H), 7.38 (ABq, J=8.4 Hz, 2H), 7.32 (ABq, J=8.4 Hz, 2H), 3.90 (s, 3H), 2.70 (q, J=7.8 Hz, 2H), 2.58 (s, 3H), 1.28 (t, J=7.8 Hz, 3H). LC-MS (ESI) 244 (M+).
2) Synthesis of methyl 4-[(2-{1-[5-(4-ethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate
1-[5-(4-Ethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.459 mmol, 112.1 mg) and 4-hydrazinocarbonylmethyl benzoate (0.459 mmol, 89.1 mg) were dissolved in dimethylformamide (9 mL) and stirred at 110° C. for 23 hours. Then, the reactor was cooled to room temperature, and the solvent was evaporated with a centrifugal evaporator. The residue was dried, and chloroform was added. The precipitated solid was recovered by filtration to give the desired product as a yellow solid (130.5 mg, yield 68%).
LC-MS (ESI) 420 (M+).
3) Synthesis of 4-[(2-{1-[5-(4-ethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
To methyl 4-[(2-{1-[5-(4-ethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate (0.172 mmol, 72.4 mg), methanol (4 mL) was added, and 1 M aqueous sodium hydroxide (5 eq., 0.861 mL) was added at room temperature. After 10 minutes of stirring at room temperature and 2 hours of stirring at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (5 eq., 0.861 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump, and the residue was further purified by silica gel thin layer chromatography (chloroform/methanol=10/1). After addition of chloroform/n-hexane, the precipitated solid was dried to give the desired product as a yellow solid (29.1 mg, yield 42%).
1H-NMR (ppm in DMSO-d6) δ 11.36 (s, 1H), 9.68 (s, 1H), 8.13-7.96 (multi, 4H), 7.50-7.35 (multi, 4H), 3.87 and 3.84 (sx2, 3H), 2.72-2.64 (multi, 2H), 2.45 (s, 3H), 1.26-1.21 (multi, 3H). LC-MS (ESI) 406 (M+).
Synthetic Example 21
Synthesis of 4-[(2-{1-[4-hydroxy-1-methyl-5-(4-n-propylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
1) Synthesis of 1-[5-(4-n-propylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone
2-Oxopropanal methylhydrazone (19.36 mmol, 1.94 g) and oxo(4-n-propylphenyl)acetaldehyde (19.0 mmol, 3.35 g) synthesized in Reference Synthetic Example 13 were dissolved in acetic acid (42 mL) and stirred at 100° C. for 6 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and purified by silica gel column chromatography (n-hexane/ethyl acetate=3/1), then by silica gel thin layer chromatography (chloroform) and by silica gel thin layer chromatography (n-hexane/ethyl acetate=7/2) to give the desired product as a brown solid (304 mg, yield 6%).
1H-NMR (ppm in CDCl3) δ 8.15 (s, 1H), 7.37 (ABq, J=8.3 Hz, 2H), 7.29 (ABq, J=8.3 Hz, 2H), 3.90 (s, 3H), 2.64 (t, J=7.5 Hz, 2H), 2.58 (s, 3H), 1.68 (q, J=7.2 Hz, 2H), 0.97 (t, J=7.2 Hz, 3H). LC-MS (ESI) 258 (M+).
2) Synthesis of methyl 4-[(2-{1-[4-hydroxy-1-methyl-5-(4-n-propylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate
1-[4-Hydroxy-1-methyl-5-(4-n-propylphenyl)-1H-pyrazol-3-yl]ethanone (0.445 mmol, 115.0 mg) and 4-hydrazinocarbonylmethyl benzoate (0.445 mmol, 86.5 mg) were dissolved in dimethylformamide (9 mL) and stirred at 110° C. for 23 hours. Then, the reactor was cooled to room temperature, and the solvent was evaporated with a centrifugal evaporator. The residue was dried, and chloroform was added. The precipitated solid was recovered by filtration to give the desired product as a yellow solid (143.3 mg, yield 74%).
LC-MS (ESI) 434 (M+).
3) Synthesis of 4-[(2-{1-[4-hydroxy-1-methyl-5-(4-n-propylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
To methyl 4-[(2-{1-[4-hydroxy-1-methyl-5-(4-n-propylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate (0.166 mmol, 72.2 mg), methanol was added, and 1 M aqueous sodium hydroxide (5 eq., 0.831 mL) was added at room temperature. After 10 minutes of stirring at room temperature and 2 hours of stirring at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (5 eq., 0.831 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump, and the residue was further purified by silica gel thin layer chromatography (chloroform/methanol=10/1). After addition of chloroform/n-hexane, the precipitated solid was recovered by filtration and dried to give the desired product as a yellow solid (47.1 mg, yield 67%).
1H-NMR (ppm in DMSO-d6) δ 11.36 (s, 1H), 9.69 (s, 1H), 8.12-7.96 (multi, 4H), 7.50-7.45 (multi, 2H), 7.39-7.33 (multi, 2H), 3.87 and 3.84 (sx2, 3H), 2.66-2.59 (multi, 2H), 2.45 (s, 3H), 1.71-1.58 (multi, 2H), 0.96-0.91 (multi, 3H). LC-MS (ESI) 420 (M+).
Synthetic Example 22
Synthesis of 4-[(2-{1-[5-(4-n-hexylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
1) Synthesis of 1-[5-(4-n-hexylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone
2-Oxopropanal methylhydrazone (16.1 mmol, 1.62 g) and (4-n-hexylphenyl)(oxo)acetaldehyde (16 mmol, 4.57 g) synthesized in Reference Synthetic Example 14 were dissolved in acetic acid (35 mL) and stirred at 100° C. for 6 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and purified by silica gel column chromatography (n-hexane/ethyl acetate=3/1), then by silica gel thin layer chromatography (chloroform) and by silica gel thin layer chromatography (n-hexane/ethyl acetate=7/2) to give the desired product as a brown solid (308 mg, yield 6%).
1H-NMR (ppm in CDCl3) δ 8.16 (s, 1H), 7.37 (ABq, J=8.1 Hz, 2H), 7.29 (ABq, J=8.1 Hz, 2H), 3.90 (s, 3H), 2.65 (t, J=7.8 Hz, 2H), 2.58 (s, 3H), 1.64-1.62 (multi, 2H), 1.41-1.28 (multi, 6H), 0.92-0.87 (multi, 3H). LC-MS (ESI) 300 (M+).
2) Synthesis of methyl 4-[(2-{1-[5-(4-n-hexylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate
1-[5-(4-n-hexylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.431 mmol, 129.6 mg) and 4-hydrazinocarbonylmethyl benzoate (0.431 mmol, 83.8 mg) were dissolved in dimethylformamide (8 mL) and stirred at 110° C. for 23 hours. Then, the reactor was cooled to room temperature, and the solvent was evaporated with a centrifugal evaporator. The residue was dried, and chloroform was added. The precipitated solid was recovered by filtration to give the desired product as a yellow solid (125.1 mg, yield 61%).
LC-MS (ESI) 476 (M+).
3) Synthesis of 4-[(2-{1-[5-(4-n-hexylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
To methyl 4-[(2-{1-[5-(4-n-hexylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate (0.158 mmol, 75.2 mg), methanol was added, and 1 M aqueous sodium hydroxide (5 eq., 0.789 mL) was added at room temperature. After 10 minutes of stirring at room temperature and 2 hours of stirring at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (5 eq., 0.789 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump, and the residue was further purified by silica gel thin layer chromatography (chloroform/methanol=10/1). After addition of chloroform/n-hexane, the precipitated solid was dried to give the desired product as a yellow solid (29.4 mg, yield 40%).
1H-NMR (ppm in DMSO-d6) δ 11.36 (s, 1H), 9.69 (s, 1H), 8.13-7.95 (multi, 4H), 7.49-7.45 (multi, 2H), 7.38-7.33 (multi, 2H), 3.87 and 3.84 (sx2, 3H), 2.67-2.61 (multi, 2H), 2.45 (s, 3H), 1.66-1.56 (multi, 2H), 1.36-1.24 (multi, 6H), 0.89-0.85 (multi, 3H). LC-MS (ESI) 462 (M+).
Synthetic Example 23
Synthesis of 4-({[2-(1-{4-hydroxy-1-methyl-5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonothioyl}amino)benzoic acid
1-[4-Hydroxy-1-methyl-5-(3-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethanone (0.229 mmol, 65.0 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.229 mmol, 48.3 mg) were stirred with dimethylformamide (2.5 mL) and three drops of concentrated hydrochloric acid at room temperature for 24 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. Chloroform/n-hexane was added to the resulting solid, and the precipitated solid was recovered by filtration and dried by means of a vacuum pump to give the desired product as a yellow solid (74.7 mg, yield 68%).
1H-NMR (ppm in DMSO-d6) δ 10.36 and 10.33 (br.sx2, 1H), 9.12 (s, 1H), 7.95-7.77 (multi, 8H), 3.86 (s, 3H), 2.41 (s, 3H). LC-MS (ESI) 477 (M+).
Synthetic Example 24
Synthesis of 4-{[(2-{1-[5-(3,5-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
1-[5-(3,5-Dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.122 mmol, 29.9 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.122 mmol, 25.9 mg) were stirred with dimethylformamide (2 mL) and two drops of concentrated hydrochloric acid at room temperature for 24 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting solid was stirred with chloroform/n-hexane for a while, then recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (34.7 mg, yield 65%).
1H-NMR (ppm in DMSO-d6) δ 10.87 (br.s, 1H), 10.33 and 10.32 (br.sx2, 1H), 8.84 (s, 1H), 7.93 (ABq, J=8.1 Hz, 2H), 7.84 (ABq, J=8.1 Hz, 2H), 7.16-7.14 (multi, 2H), 7.06 (br.s, 1H), 3.81 and 3.79 (sx2, 3H), 2.46 and 2.39 (sx2, 3H), 2.35-2.31 (multi, 6H). LC-MS (ESI) 437 (M+).
Synthetic Example 25
Synthesis of 4-{[(2-{1-[4-hydroxy-5-(4-isopropylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
1-[4-Hydroxy-5-(4-isopropylphenyl)-1-methyl-1H-pyrazol-3-yl]ethanone (0.116 mmol, 29.9 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.116 mmol, 24.5 mg) were stirred with dimethylformamide (2 mL) and two drops of concentrated hydrochloric acid at room temperature for 24 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting solid was stirred with chloroform/n-hexane for a while, then recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (37.7 mg, yield 72%).
1H-NMR (ppm in DMSO-d6) δ 10.90 (br.s, 1H), 10.35 and 10.33 (br.sx2, 1H), 8.85 (s, 1H), 7.93 (ABq, J=8.6 Hz, 2H), 7.85 (ABq, J=8.6 Hz, 2H), 7.47 (ABq, J=8.1 Hz, 2H), 7.39 (ABq, J=8.1 Hz, 2H), 3.83 and 3.81 (sx2, 3H), 2.95 (sept, J=6.9 Hz, 1H), 2.46 and 2.39 (sx2, 3H), 1.27-1.24 (multi, 6H). LC-MS (ESI) 451 (M+).
Synthetic Example 26
Synthesis of 4-{[(2-{1-[4-hydroxy-5-(4-isobutylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
1-[4-Hydroxy-5-(4-isobutylphenyl)-1-methyl-1H-pyrazol-3-yl]ethanone (0.179 mmol, 48.8 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.179 mmol, 37.9 mg) were stirred with dimethylformamide (2.5 mL) and three drops of concentrated hydrochloric acid at room temperature for 24.5 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting solid was stirred with chloroform/n-hexane for a while, then recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (62.6 mg, yield 75%).
1H-NMR (ppm in DMSO-d6) δ 10.87 (br.s, 1H), 10.34 (br.s, 1H), 8.85 (s, 1H), 7.93 (ABq, J=8.6 Hz, 2H), 7.85 (ABq, J=8.6 Hz, 2H), 7.46 (ABq, J=8.3 Hz, 2H), 7.30 (ABq, J=8.3 Hz, 2H), 3.83 and 3.81 (sx2, 3H), 2.54-2.51 (multi, 2H), 2.46 and 2.39 (sx2, 3H), 1.89 (sept, J=6.8 Hz, 1H), 0.92-0.89 (multi, 6H). LC-MS (ESI) 465 (M+).
Synthetic Example 27
Synthesis of 4-{[(2-{1-[5-(3-bromo-4-fluorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
1-[5-(3-Bromo-4-fluorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.139 mmol, 43.6 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.139 mmol, 29.4 mg) were stirred with dimethylformamide (2.5 mL) and three drops of concentrated hydrochloric acid at room temperature for 24.5 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting solid was stirred with chloroform/n-hexane for a while, then recovered by filtration and dried by means of a vacuum pump to give the desired product as a yellow solid (51.8 mg, yield 74%).
1H-NMR (ppm in DMSO-d6) δ 10.35 and 10.32 (br.sx2, 1H), 9.08 (s, 1H), 7.98-7.79 (multi, 5H), 7.65-7.51 (multi, 2H), 3.83 (s, 3H), 2.46 and 2.39 (sx2, 3H). LC-MS (ESI) 505, 507 (M+).
Synthetic Example 28
Synthesis of 4-{[(2-{1-[5-(4-ethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
1-[5-(4-Ethylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethanone (0.159 mmol, 38.8 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.159 mmol, 33.6 mg) were stirred with dimethylformamide (2.3 mL) and three drops of concentrated hydrochloric acid at room temperature for 23.5 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting solid was stirred with chloroform/n-hexane for a while, then recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (50.6 mg, yield 73%).
1H-NMR (ppm in DMSO-d6) δ 10.87 (br.s, 1H), 10.33 (br.s, 1H), 8.85 (s, 1H), 7.93 (ABq, J=8.7 Hz, 2H), 7.85 (ABq, J=8.7 Hz, 2H), 7.46 (ABq, J=8.1 Hz, 2H), 7.36 (ABq, J=8.1 Hz, 2H), 3.82 and 3.80 (sx2, 3H), 2.67 (q, J=7.S Hz, 2H), 2.46 and 2.39 (sx2, 3H), 1.26-1.20 (multi, 3H). LC-MS (ESI) 437 (M+).
Synthetic Example 29
Synthesis of 4-{[(2-{1-[4-hydroxy-1-methyl-5-(4-n-propylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
1-[4-Hydroxy-1-methyl-5-(4-n-propylphenyl)-1H-pyrazol-3-yl]ethanone (0.157 mmol, 40.5 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.157 mmol, 33.1 mg) were stirred with dimethylformamide (2.3 mL) and three drops of concentrated hydrochloric acid at room temperature for 23.5 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting solid was stirred with chloroform/n-hexane for a while, then recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (56.2 mg, yield 79%).
1H-NMR (ppm in DMSO-d6) δ 10.32 (br.s, 1H), 8.85 (s, 1H), 7.93 (ABq, J=8.7 Hz, 2H), 7.85 (ABq, J=8.7 Hz, 2H), 7.46 (ABq, J=8.1 Hz, 2H), 7.34 (ABq, J=8.1 Hz, 2H), 3.82 and 3.80 (sx2, 3H), 2.62 (t, J=7.7 Hz, 2H), 2.46 and 2.39 (sx2, 3H), 1.70-1.57 (multi, 2H), 0.97-0.91 (multi, 3H). LC-MS (ESI) 451 (M+).
Synthetic Example 30
Synthesis of 4-{[(2-{1-[5-(4-n-hexylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}benzoic acid
1-[5-(4-n-Hexylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethanone (0.117 mmol, 35.1 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.117 mmol, 24.7 mg) were stirred with dimethylformamide (2.3 mL) and three drops of concentrated hydrochloric acid at room temperature for 23.5 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting solid was stirred with chloroform/n-hexane for a while, then recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (46.3 mg, yield 80%).
1H-NMR (ppm in DMSO-d6) δ 10.87 (br.s, 1H), 10.33 (br.s, 1H), 8.84 (s, 1H), 7.93 (ABq, J=8.6 Hz, 2H), 7.84 (ABq, J=8.6 Hz, 2H), 7.45 (ABq, J=8.1 Hz, 2H), 7.33 (ABq, J=8.1 Hz, 2H), 3.82 and 3.80 (sx2, 3H), 2.63 (t, J=7.7 Hz, 2H), 2.46 and 2.39 (sx2, 3H), 1.61 (multi, 2H), 1.30 (multi, 6H), 0.86 (multi, 3H). LC-MS (ESI) 493 (M+).
Synthetic Example 31
Synthesis of 4-[(2-{1-[5-(4-t-butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonyl]benzoic acid
1) Synthesis of methyl 4-[(2-{1-[5-(4-t-butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate
1-[5-(4-t-Butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethanone (0.313 mmol, 89.5 mg), 4-hydrazinocarbonylmethyl benzoate (0.313 mmol, 60.7 mg) and p-tosylic acid monohydrate (30 mol %, 16.1 mg) were dissolved in isopropyl alcohol (16 mL) and stirred at 100° C. for 19 hours. The reactor was cooled to room temperature, and the solvent was evaporated. The resulting crude product was purified by silica gel column chromatography (chloroform/methanol=10/1) and then by silica gel column chromatography (n-hexane/ethyl acetate=1/2) to give the desired product as a yellow solid (16.8 mg, yield 12%).
1H-NMR (ppm in DMSO-d6) δ 11.39 (br.s, 1H), 9.60 (br.s, 1H), 8.10 (ABq, J=8.3 Hz, 2H), 8.04 (ABq, J=8.3 Hz, 2H), 7.55 (ABq, J=8.1 Hz, 2H), 7.44 (ABq, J=8.1 Hz, 2H), 4.12 (q, J=7.2 Hz, 2H), 3.90 (s, 3H), 2.46 (s, 3H), 1.34 (s, 9H), 1.29 (t, J=7.2 Hz, 3H) LC-MS (ESI) 462 (M+).
2) Synthesis of 4-[(2-{1-[5-(4-t-butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
To methyl 4-[(2-{1-[5-(4-t-butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate (0.032 mmol, 15.0 mg), methanol (1.5 mL) was added, and 1 M aqueous sodium hydroxide (0.162 mmol, 0.162 mL) was added at room temperature. After 30 minutes of stirring at room temperature and 1.25 hours of stirring at 60° C., the reactor was cooled to 0° C., and 1 M hydrochloric acid (0.162 mmol, 0.162 mL) and water were added. The precipitated solid was recovered by filtration, washed with water, dried by means of a vacuum pump and purified by silica gel thin layer chromatography (chloroform/methanol=10/1) to give the desired product as a yellow solid (6.4 mg, yield 44%).
1H-NMR (ppm in DMSO-d6) δ 11.33 (br.s, 1H), 9.64 (br.s, 1H), 8.06-7.94 (multi, 4H), 7.58-7.43 (multi, 4H), 4.12 (q, J=7.5 Hz, 2H), 2.46 and 2.44 (sx2, 3H), 1.34 (s, 9H), 1.27 (t, J=7.5 Hz, 3H). LC-MS (ESI) 448 (M+).
Synthetic Example 32
Synthesis of 4-[(2-{1-[1-benzyl-5-(4-t-butylphenyl)-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
1) Synthesis of methyl 4-[(2-{1-[1-benzyl-5-(4-t-butylphenyl)-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate
1-[1-Benzyl-5-(4-t-butylphenyl)-4-hydroxy-1H-pyrazol-3-yl]ethanone (0.610 mmol, 212.6 mg), 4-hydrazinocarbonylmethyl benzoate (0.610 mmol, 118.5 mg) and p-tosylic acid monohydrate (30 mol %, 31.5 mg) were dissolved in isopropyl alcohol (20 mL) and stirred at 100° C. for 18 hours. The reactor was cooled to room temperature, and the solvent was evaporated. The resulting crude product was purified by silica gel column chromatography (chloroform/methanol=10/1) and then by silica gel column chromatography (n-hexane/ethyl acetate=1/2) to give the desired product as a yellow solid (56.6 mg, yield 18%).
1H-NMR (ppm in DMSO-d6) δ 11.44 (br.s, 1H), 9.72 (br.s, 1H), 8.11 (ABq, J=8.1 Hz, 2H), 8.05 (ABq, J=8.1 Hz, 2H), 7.49 (ABq, J=8.3 Hz, 2H), 7.37 (ABq, J=8.3 Hz, 2H), 7.32-7.22 (multi, 3H), 6.99-6.97 (multi, 2H), 5.38 (s, 2H), 3.91 (s, 3H), 2.46 (s, 3H), 1.30 (s, 9H). LC-MS (ESI) 524 (M+).
2) Synthesis of 4-[(2-{1-[1-benzyl-5-(4-t-butylphenyl)-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
To methyl 4-[(2-{1-[1-benzyl-5-(4-t-butylphenyl)-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate (0.045 mmol, 23.5 mg), methanol was added, and 1 M aqueous sodium hydroxide (0.224 mmol, 0.224 mL) was added at room temperature. After 30 minutes of stirring at room temperature and 1.5 hours of stirring at 60° C., the reactor was cooled to 0° C., and 1 M hydrochloric acid (0.224 mmol, 0.224 mL) and water were added. The precipitated solid was recovered by filtration, washed with water, dried by means of a vacuum pump and purified by silica gel thin layer chromatography (chloroform/methanol=10/1) to give the desired product as a yellow solid (15.8 mg, yield 69%).
1H-NMR (ppm in DMSO-d6) δ 11.41 (br.s, 1H), 9.74 (br.s, 1H), 8.06-6.97 (multi, 13H), 5.38 (s, 2H), 2.46 (s, 3H), 1.30 (s, 9H). LC-MS (ESI) 510 (M+).
Synthetic Example 33
Synthesis of methyl 5-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate
1-[5-(4-t-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (38.0 mg, 0.14 mmol) and methyl 5-hydrazinocarbonyl-2-thiophenecarboxylate (27.9 mg, 0.14 mmol) were dissolved in dimethylformamide (2.0 mL) and stirred at 110° C. for 12 hours. After cooling, the solvent was evaporated, and ethyl acetate was added to the resulting crude product. The precipitated solid was recovered by filtration to give 20.0 mg of the desired product as a pale yellow solid (yield 31%).
1H-NMR (ppm in CDCl3) δ 7.78 (d, J=3.6 Hz, 1H), 7.42-7.52 (multi, 5H), 3.92 (s, 3H), 3.88 (s, 3H), 2.45 (s, 3H), 1.36 (s, 9H). LC-MS (ESI) 454 (M+).
Synthetic Example 34
Synthesis of 5-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylic acid
Methyl 5-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate (16.0 mg, 0.035 mmol) in methanol (1.5 mL) was stirred with 1 M aqueous sodium hydroxide (176 μL, 0.176 mmol) at room temperature for 17 hours. After the stirring, 1 M hydrochloric acid (176 μL, 0.176 mmol) was added, and the precipitated solid was recovered by filtration to give 6.2 mg of the desired product as yellow crystals (yield 40%).
1H-NMR (ppm in DMSO-d6) δ 11.36 (br.s, 1H), 9.50 (br.s, 1H), 8.02 (d, J=4.5 Hz, 1H), 7.79 (d, J=4.5 Hz, 1H), 7.48-7.56 (multi, 4H), 3.84 (s, 3H), 2.45 (s, 3H), 1.33 (s, 9H). LC-MS (ESI) 440 (M+).
Synthetic Example 35
Synthesis of methyl 4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate
2-(4-t-Butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (100 mg, 0.36 mmol) synthesized in Reference Synthetic Example 33 and 4-hydrazinocarbonylmethyl benzoate (70 mg, 0.36 mmol) were stirred in dimethylformamide (3.6 mL) at 120° C. overnight. The reaction solution was partitioned between ethyl acetate-saturated aqueous ammonium chloride, and the organic layer was washed with saturated aqueous sodium chloride. The precipitated solid was recovered from the solution by filtration to give the desired product as a pale yellow solid (58 mg, yield 36%).
1H-NMR (ppm in DMSO-6) δ 1.30 (s, 9H), 3.91 (s, 3H), 7.43 (d, J=8.2 Hz, 2H), 7.71 (d, J=8.2 Hz, 2H), 7.99-8.13 (m, 5H), 11.48 (s, 1H), 12.23 (s, 1H). 1H-NMR (ppm in MeOH-d4) δ 1.34 (s, 9H), 2.48 (s, 3H), 3.95 (s, 3H), 7.39-8.16 (m, 9H). LC/MS (ES+) 451.
Synthetic Example 36
Synthesis of methyl 4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate
2-(3,4-Dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (100 mg, 0.35 mmol) synthesized in Reference Synthetic Example 34 and 4-hydrazinocarbonylmethyl benzoate (68 mg, 0.35 mmol) were stirred in dimethylformamide (3.6 mL) at 120° C. under heating overnight. The resulting reaction solution was concentrated, and ethyl acetate/n-hexane was added. The precipitated solid was recovered by filtration to give the desired product as a pale yellow solid (141 mg, yield 87%).
1H-NMR (ppm in DMSO-6) δ 3.91 (s, 3H), 7.64-7.73 (m, 2H), 8.05-8.13 (m, 6H), 11.55 (bs, 1H). LC/MS (ES−) 461, 462, 464.
Synthetic Example 37
Synthesis of methyl 4-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate
From 2-(4-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene (100 mg, 0.35 mmol) synthesized in Reference Synthetic Example 35, the desired product was obtained in the same manner as in Synthetic Example 36 as a pale yellow solid (132 mg, yield 82%).
1H-NMR (ppm in MeOH-d4) δ 2.49 (s, 3H), 3.95 (s, 3H), 7.64-7.67 (m, 2H), 7.88 (s, 1H), 8.03-8.04 (m, 4H), 8.15-8.18 (m, 2H). LC/MS (ES+) 463.
Synthetic Example 38
Synthesis of methyl 2-nitro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}-hydrazino)carbonyl]benzoate
2-(4-t-Butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (80 mg, 0.29 mmol) and methyl 2-nitro-4-hyrazinocarbonylbenzoate (69 mg, 0.29 mmol) were stirred in dimethylformamide (2.9 mL) at 120° C. under heating overnight. The resulting reaction solution was concentrated, and ethyl acetate/n-hexane was added. The precipitated solid was recovered by filtration to give the desired product as a brown solid (92 mg, yield 64%).
1H-NMR (ppm in DMSO-6) δ 1.30 (s, 9H), 3.90 (s, 3H), 7.43 (d, J=8.4 Hz, 2H), 7.71 (d, J=8.4 Hz, 2H), 8.02-8.07 (m, 2H), 8.36 (d, J=7.4 Hz, 1H), 8.59 (s, 1H) LC/MS (ES+) 496.
Synthetic Example 39
Synthesis of methyl 5-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate
2-(4-t-Butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (80 mg, 0.29 mmol) and methyl 5-hydrazinocarbonyl-2-thiophenecarboxylate (58 mg, 0.29 mmol) were stirred in dimethylformamide (2.9 mL) at 120° C. under heating overnight. The resulting reaction solution was concentrated, and chloroform/n-hexane was added. The precipitated solid was recovered by filtration to give the desired product as a yellow solid (79 mg, yield 60%).
1H-NMR (ppm in MeOH-d4) δ 1.34 (s, 9H), 2.48 (s, 3H), 3.91 (s, 3H), 7.38-7.81 (m, 7H). LC/MS (ES+) 457.
Synthetic Example 40
Synthesis of methyl 4-[(2-{[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]methylene}hydrazino)carbonyl]benzoate
2-(4-t-Butylphenyl)-3-hydroxy-4-formylthiophene (100 mg, 0.38 mmol) synthesized in Reference Synthetic Example 25 and 4-hydrazinocarbonylmethyl benzoate (74 mg, 0.38 mmol) were stirred in dimethylformamide (3.8 mL) at room temperature overnight. The reaction solution was partitioned between ethyl acetate-water, and the organic layer was washed with saturated aqueous sodium chloride. The resulting organic layer was concentrated and purified by silica gel column chromatography (chloroform) to give the desired product as a light brown solid (74 mg, yield 46%).
1H-NMR (ppm in DMSO-6) δ 1.30 (s, 9H), 3.91 (s, 3H), 7.44 (d, J=8.4 Hz, 2H), 7.69 (d, J=8.4 Hz, 2H), 7.93-7.95 (m, 2H), 8.06-8.15 (m, 4H), 8.57 (s, 1H), 10.87 (s, 1H), 12.40 (s, 1H). LC/MS (ES+) 437.
Synthetic Example 41
Synthesis of methyl 4-[(2-{[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]methylene}hydrazino)carbonyl]benzoate
2-(3,4-Dichlorophenyl)-3-hydroxy-4-formylthiophene (104 mg, 0.38 mmol) synthesized in Reference Synthetic Example 26 and 4-hydrazinocarbonylmethyl benzoate (74 mg, 0.38 mmol) were stirred in dimethylformamide (3.8 mL) at room temperature overnight. Water was added to the reaction solution, and the precipitated solid was recovered by filtration to give the desired product as a pale yellow solid (175 mg, yield 100%).
1H-NMR (ppm in DMSO-6) δ 3.91 (s, 3H), 7.65-7.72 (m, 2H), 7.96-8.14 (m, 7H), 8.62 (s, 1H), 11.37 (bs, 1H). LC/MS (ES+) 451, 452, 453.
Synthetic Example 42
Synthesis of 4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoic acid
Methyl 4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate (50 mg, 0.11 mmol) synthesized in Synthetic Example 35 was dissolved in methanol (1.1 mL) and stirred with 1 M aqueous sodium hydroxide (0.55 mL, 0.55 mmol) at 45° C. for 1.5 hours. After the stirring, 1 M hydrochloric acid (0.55 mL, 0.55 mmol) was added, and the precipitated pale yellow solid was recovered by filtration. The resulting solid was purified by silica gel chromatography (chloroform:methanol=9:1). The resulting solid was stirred with chloroform at room temperature and recovered by filtration to give the desired product as a pale yellow solid (11 mg, yield 23%).
1H-NMR (ppm in MeOH-d4) δ 1.34 (s, 9H), 2.48 (s, 3H), 7.39-8.08 (m, 9H). LC/MS (ES+)437.
Synthetic Example 43
Synthesis of 4-[(2-{[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]methylene}hydrazino)carbonyl]benzoic acid
From methyl 4-[(2-{[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]methylene}hydrazino)carbonyl]benzoate (62 mg, 0.14 mmol) synthesized in Synthetic Example 40, the desired product was obtained in the same manner as in Synthetic Example 42 as a pale yellow solid (34 mg, yield 57%).
1H-NMR (ppm in DMSO-6) δ 1.30 (s, 9H), 7.44 (d, J=8.4 Hz, 2H), 7.69 (d, J=8.4 Hz, 2H), 7.93 (s, 1H), 8.03-8.09 (m, 4H), 8.58 (s, 1H), 10.88 (s, 1H), 12.38 (bs, 1H) LC/MS (ES+) 423.
Synthetic Example 44
Synthesis of 4-[(2-{[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]methylene}hydrazino)carbonyl]benzoic acid
From methyl 4-[(2-{[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]methylene}hydrazino)carbonyl]benzoate (120 mg, 0.27 mmol) synthesized in Synthetic Example 41, the desired product was obtained in the same manner as in Synthetic Example 42 as a pale yellow solid (44 mg, yield 37%).
1H-NMR (ppm in DMSO-6) δ 7.66-7.72 (m, 2H), 8.03-8.21 (m, 6H), 8.58 (s, 1H), 11.37 (bs, 1H).
Synthetic Example 45
Synthesis of 4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoic acid
From methyl 4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate (100 mg, 0.22 mmol) synthesized in Synthetic Example 36, the desired product was obtained in the same manner as in Synthetic Example 42 as a pale yellow solid (9 mg, yield 9%).
1H-NMR (ppm in DMSO-6) δ 7.64-7.73 (m, 2H), 8.01-8.12 (m, 6H). 1H-NMR (ppm in MeOH-d4) δ 2.47 (s, 3H), 7.47-8.16 (m, 8H). LC/MS (ES+) 449, 450, 451.
Synthetic Example 46
Synthesis of 4-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoic acid
From methyl 4-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate (100 mg, 0.22 mmol) synthesized in Synthetic Example 37, the desired product was obtained in the same manner as in Synthetic Example 42 as a colorless solid (34 mg, yield 34%).
1H-NMR (ppm in DMSO-6) δ 7.75-7.78 (m, 2H), 8.00-8.15 (m, 7H), 11.51 (bs, 1H). LC/MS (ES−) 447.
Synthetic Example 47
Synthesis of 2-nitro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoic acid
From methyl 2-nitro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate (60 mg, 0.12 mmol) synthesized in Synthetic Example 38, the desired product was obtained in the same manner as in Synthetic Example 42 as a yellow solid (10 mg, yield 17%).
1H-NMR (ppm in DMSO-6) δ 1.30 (s, 9H), 7.43 (d, J=8.4 Hz, 2H), 7.71 (d, J=8.4 Hz, 2H), 7.95-8.03 (m, 2H), 8.30 (d, J=8.0 Hz, 1H), 8.51 (s, 1H). 1H-NMR (ppm in MeOH-d4) δ 1.34 (s, 9H), 2.49 (s, 3H), 7.39-8.46 (m, 8H). LC/MS (ES+) 482.
Synthetic Example 48
Synthesis of 5-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylic acid
From methyl 5-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate (72 mg, 0.16 mmol) synthesized in Synthetic Example 39, the desired product was obtained in the same manner as in Synthetic Example 42 as a yellow solid (12 mg, yield 17%).
1H-NMR (ppm in DMSO-6) δ 1.30 (s, 9H), 7.43 (d, J=8.5 Hz, 2H), 7.70 (d, J=8.5 Hz, 2H), 7.81 (d, J=4.1 Hz, 1H), 8.00 (s, 1H), 8.04 (d, J=4.1 Hz, 1H). LC/MS (ES−) 442.
Synthetic Example 49
Synthesis of 4-{[(2-{[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]methylene}hydrazino)carbonothioyl]amino}benzoic acid
2-(4-t-Butylphenyl)-3-hydroxy-4-formylthiophene (50 mg, 0.19 mmol) synthesized in Reference Synthetic Example 25 and 4-hydrazinocarbonothioylaminobenzoic acid (40 mg, 0.19 mmol) were stirred with dimethylformamide (1.9 mL) and concentrated hydrochloric acid (0.1 mL) at room temperature for 12 hours. The reaction solution was partitioned between ethyl acetate and water, and the organic layer was washed with saturated aqueous sodium chloride and dried over anhydrous sodium sulfate. The resulting organic layer was concentrated and purified by silica gel column chromatography (chloroform). Methanol/chloroform was added to the resulting crude product, and the precipitated yellow solid was recovered by filtration to give the desired product as a pale yellow solid (20 mg, yield 23%).
1H-NMR (ppm in DMSO-6) δ 1.30 (s, 9H), 7.43 (d, J=8.5 Hz, 2H), 7.67 (d, J=8.5 Hz, 2H), 7.79 (d, J=8.5 Hz, 2H), 7.93-7.99 (m, 3H), 8.24 (s, 1H), 10.32 (s, 1H), 11.93 (s, 1H). LC/MS (ES+) 454.
Synthetic Example 50
Synthesis of 4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
2-(4-t-Butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (31 mg, 0.11 mmol) synthesized in Reference Synthetic Example 33 and 4-hydrazinocarbonothioylaminobenzoic acid (23 mg, 0.11 mmol) were stirred with dimethylformamide (1.1 mL) and concentrated hydrochloric acid (0.05 mL) at room temperature for 30 hours. The reaction solution was partitioned between ethyl acetate and water, and the organic layer was washed with saturated aqueous sodium chloride and dried over anhydrous sodium sulfate. The resulting organic layer was concentrated and purified by silica gel column chromatography (chloroform) to give the desired product as a light brown solid (27 mg, yield 52%).
1H-NMR (ppm in DMSO-6) δ 1.30 (s, 9H), 2.39 (s, 3H), 7.43 (d, J=8.5 Hz, 2H), 7.69 (d, J=8.5 Hz, 2H), 7.86-7.95 (m, 5H), 10.40 (s, 1H), 11.08 (s, 1H). LC/MS (ES+) 468.
Synthetic Example 51
Synthesis of 4-{[(2-{[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]methylene}hydrazino)carbonothioyl]amino}benzoic acid
2-(3,4-Dichlorophenyl)-3-hydroxy-4-formylthiophene (52 mg, 0.19 mmol) synthesized in Reference Synthetic Example 26 and 4-hydrazinocarbonothioylaminobenzoic acid (40 mg, 0.19 mmol) were stirred with dimethylformamide (1.9 mL) and concentrated hydrochloric acid (0.1 mL) at room temperature for 14 hours. Water was added to the reaction solution, and the precipitated solid was recovered by filtration and dried. The crude product was stirred with chloroform at room temperature and recovered by filtration to give the desired product as a pale yellow solid (58 mg, yield 65%).
1H-NMR (ppm in DMSO-6) δ 7.67-8.10 (m, 8H), 8.25 (s, 1H), 10.34 (s, 1H), 11.95 (s, 1H) LC/MS (ES+) 465, 467, 469.
Synthetic Example 52
Synthesis of 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethyliden}hydrazino)carbonothioyl]amino}benzoic acid
From 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (50 mg, 0.17 mmol) synthesized in Reference Synthetic Example 34, the desired product was obtained in the same manner as in Synthetic Example 51 as a pale yellow solid (23 mg, yield 28%).
LC/MS (ES+) 480, 481, 482, 484.
Synthetic Example 53
Synthesis of 4-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethyliden}hydrazino)carbonothioyl]-amino}benzoic acid
From 2-(4-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene (50 mg, 0.17 mmol) synthesized in Reference Synthetic Example 35, the desired product was obtained in the same manner as in Synthetic Example 51 as a pale yellow solid (48 mg, 59%).
1H-NMR (ppm in DMSO-6) δ 2.41 (s, 3H), 7.74-8.11 (m, 9H), 10.49 (s, 1H), 11.18 (s, 1H). LC/MS (ES+) 480.
Synthetic Example 54
Synthesis of 4-({2-[[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl](phenyl)methylene]hydrazino}carbonyl)benzoic acid
1) Synthesis of [5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl](phenyl)methanone
Oxo(phenyl)acetaldehyde methylhydrazone (5.46 mmol, 886 mg) synthesized in Reference Synthetic Example 36 and (4-t-butylphenyl)(oxo)acetaldehyde (5 mmol, 951 mg) were dissolved in acetic acid (26 mL) and stirred at 100° C. for about 2 hours. Then, the solvent was evaporated, and the residue was recrystallized from chloroform/n-hexane to give the desired product as a yellow solid (993 mg, yield 59%).
1H-NMR (ppm in CDCl3) δ 9.04 (s, 1H), 8.51-8.48 (multi, 2H), 7.61-7.59 (multi, 1H), 7.55-7.44 (multi, 6H), 3.98 (s, 3H), 1.37 (s, 9H). LC-MS (ESI) 334 (M+).
2) Synthesis of methyl 4-({2-[[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl](phenyl)methylene]hydrazino}carbonyl)benzoate
[5-(4-t-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl](phenyl)methanone (0.299 mmol, 99.9 mg), 4-hydrazinocarbonylmethyl benzoate (0.299 mmol, 58.0 mg) and p-tosylic acid monohydrate (30 mol %, 15.4 mg) were dissolved in isopropyl alcohol (12 mL) and stirred at 100° C. for about 24 hours. Then, the reactor was cooled to room temperature, and the precipitated solid was recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (119 mg, yield 78%).
1H-NMR (ppm in DMSO-d6) δ 11.29 (s, 1H), 9.85 (s, 1H), 8.03 (ABq, J=8.3 Hz, 2H), 7.84 (ABq, J=8.3 Hz, 2H), 7.62-7.55 (multi, 9H), 3.90 and 3.87 (sx2, 3H), 3.77 and 3.73 (sx2, 3H), 1.34 and 1.32 (sx2, 9H). LC-MS (ESI) 510 (M+).
3) Synthesis of 4-({2-[[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl](phenyl)methylene]hydrazino}carbonyl)benzoic acid
To methyl 4-({2-[[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl](phenyl)methylene]hydrazino}carbonyl)benzoate (0.196 mmol, 100 mg), methanol (4 mL) was added, and 1 M aqueous sodium hydroxide (0.981 mmol, 0.981 mL) was added at room temperature. After 15 minutes of stirring at room temperature and 1 hour of stirring at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (0.981 mmol, 0.981 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the desired product as a yellow solid (93 mg, yield 95%).
1H-NMR (ppm in DMSO-d6) δ 11.25 (s, 1H), 9.86 (s, 1H), 8.00 (ABq, J=8.3 Hz, 2H), 7.81 (ABq, J=8.3 Hz, 2H), 7.62-7.55 (multi, 9H), 3.77 and 3.73 (sx2, 3H), 1.34 and 1.32 (sx2, 9H). LC-MS (ESI) 496 (M+).
Synthetic Example 55
Synthesis of 4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene]hydrazino}carbonyl)-N-methylbenzenesulfonamide
1-[5-(4-t-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.228 mmol, 62 mg), 4-(hydrazinocarbonyl)-N-methylbenzenesulfonamide (0.228 mmol, 52 mg) and p-tosylic acid monohydrate (30 mol %, 11.8 mg) were dissolved in isopropyl alcohol (6 mL) and stirred at 100° C. for 19 hours. Then, the solvent was evaporated, and the residue was purified by silica gel thin layer chromatography (chloroform/methanol=10/1) to give the desired product as a yellow solid (30.3 mg, yield 28%).
1H-NMR (ppm in DMSO-d6) δ 11.40 (s, 1H), 9.65 (s, 1H), 8.32 (s, 1H), 8.10 (ABq, J=8.4 Hz, 2H), 7.91 (ABq, J=8.4 Hz, 2H), 7.57-7.49 (multi, 4H), 3.89 and 3.85 (sx2, 3H), 2.46 (s, 3H), 2.45 (S, 3H), 1.34 (s, 9H). LC-MS (ESI) 483 (M+).
Synthetic Example 56
Synthesis of 4-({2-[[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl](phenyl)methylene]hydrazino}carbonyl)-N-methylbenzenesulfonamide
[5-(4-t-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl](phenyl)methanone (0.254 mmol, 85 mg), 4-(hydrazinocarbonyl)-N-methylbenzenesulfonamide (0.254 mmol, 58 mg) and p-tosylic acid monohydrate (30 mol %, 13 mg) were dissolved in isopropyl alcohol (8.5 mL) and stirred at 100° C. for 19 hours. Then, the solvent was evaporated, and the residue was purified by silica gel thin layer chromatography (chloroform/methanol=10/1) to give the desired product as a yellow solid (30.3 mg, yield 22%).
1H-NMR (ppm in DMSO-d6) δ 11.69 and 11.32 (sx2, 1H), 9.84 and 8.64 (sx2, 1H), 8.64 (s, 1H), 8.09-7.82 (multi, 4H), 7.69-7.44 (multi, 9H), 3.91-3.73 (multi, 3H), 2.47 and 2.38 (multi, 3H), 1.34-1.33 (sx2, 9H). LC-MS (ESI) 545 (M+).
Synthetic Example 57
Synthesis of N′-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}-4-(1H-tetrazol-5-yl)benzhydrazide
1-[5-(4-t-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.404 mmol, 110 mg) and 4-(1-H-tetrazol-5-yl)benzhydrazide (0.404 mmol, 83 mg) synthesized in accordance with WO03/037328 were dissolved in dimethylformamide (5 mL) and stirred at 100° C. for 26 hours. The insolubles were filtered off and washed with methanol, and the filtrate was concentrated and separated by silica gel thin layer chromatography (chloroform/MeOH=4/1) to give the desired product as a yellow solid (25 mg, yield 13%).
1H-NMR (ppm in DMSO-d6) δ 11.22 (s, 1H), 9.76 (s, 1H), 8.13 (ABq, J=8.3 Hz, 2H), 7.99 (ABq, J=8.3 Hz, 2H), 7.57-7.50 (multi, 4H), 3.91 and 3.85 (sx2, 3H), 2.46 and 2.42 (sx2, 3H), 1.34 (s, 9H). LC-MS (ESI) 458 (M+).
Synthetic Example 58
Synthesis of 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-nitrobenzoic acid
1) Synthesis of methyl 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-nitrobenzoate
1-[5-(4-tert-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (1.149 mmol, 312.9 mg) synthesized in Synthetic Example 3, methyl 2-nitro-4-hydrazinocarbonylbenzoate (1.149 mmol, 274.8 mg) synthesized in Reference Synthetic Example 40 and p-tosylic acid monohydride (30 mol %, 59.4 mg) were dissolved in isopropyl alcohol (30 mL) and stirred under heating with reflux for 6 hours, and the reactor was cooled to 0° C. The reaction solution was filtered and dried by means of a vacuum pump to give the desired product as a yellow solid (470 mg, yield 83%).
1H-NMR (ppm in DMSO-d6) δ 11.54 (s, 1H), 9.57 (s, 1H), 8.57 (s, 1H), 8.33 (d, J=8.0 Hz, 1H), 8.04 (d, J=8.0 Hz, 1H), 7.55 (ABq, J=8.4 Hz, 2H), 7.50 (ABq, J=8.4 Hz, 2H), 3.90 (s, 3H), 3.85 (s, 3H), 2.46 (s, 3H), 1.33 (s, 9H) LC-MS (ESI) 493 (M+)
2) Synthesis of 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-nitrobenzoic acid
To methyl 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-nitrobenzoate (0.945 mmol, 466.2 mg), methanol (33 mL) was added, and 1 M aqueous sodium hydroxide (4.7 mmol, 4.7 mL) was added. After about 26 hours of stirring at room temperature and 3 hours of stirring at 40° C., 1 M hydrochloric acid (4.7 is mmol, 4.7 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting yellow solid (359.5 mg) was dissolved in THF (50 mL) and stirred at room temperature for 2 days. The insolubles were filtered off, and the filtrate was concentrated and dried by means of a vacuum pump. After addition of chloroform, the precipitated solid was recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (260.7 mg, yield 58%).
1H-NMR (ppm in DMSO-d6) δ 11.50 (s, 1H), 9.58 (s, 1H), 8.47 (s, 1H), 8.27 (d, J=8.1 Hz, 1H), 7.99 (d, J=8.1 Hz, 1H), 7.55 (ABq, J=8.4 Hz, 2H), 7.50 (ABq, J=8.4 Hz, 2H), 3.85 (s, 3H), 2.46 (s, 3H), 1.33 (s, 9H) LC-MS (ESI) 479 (M+)
Synthetic Example 59
Synthesis of 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-chlorobenzoic acid
1) Synthesis of methyl 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-chlorobenzoate
1-[5-(4-tert-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.568 mmol, 154.8 mg) synthesized in Synthetic Example 3, methyl 2-chloro-4-hydrazinocarbonylbenzoate (0.568 mmol, 130.0 mg) synthesized in Reference Synthetic Example 41 and p-tosylic acid monohydride (30 mol %, 29.4 mg) were dissolved in isopropyl alcohol (15 mL) and stirred under heating with reflux for 8 hours, and the reactor was cooled to 0° C. The reaction solution was filtered and dried by means of a vacuum pump to give the desired product as a white solid (233.7 mg, yield 85%).
1H-NMR (ppm in DMSO-d6) δ 11.42 (s, 1H), 9.61 (s, 1H), 8.10 (s, 1H), 7.95 (s, 2H), 7.55 (ABq, J=8.6 Hz, 2H), 7.50 (ABq, J=8.6 Hz, 2H), 3.91 (s, 3H), 3.85 (s, 3H), 2.45 (s, 3H), 1.33 (s, 9H) LC-MS (ESI) 482 (M+)
2) Synthesis of 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-chlorobenzoic acid
To methyl 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-chlorobenzoate (0.465 mmol, 224.8 mg), methanol (20 mL) was added, and 1 M aqueous sodium hydroxide (2.3 mmol, 2.3 mL) was added. After 5 hours of stirring at 50° C., 14 hours of stirring at room temperature and 4 hours of stirring at 50° C., 1 M hydrochloric acid (2.3 mmol, 2.3 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the crude desired product as a yellow solid (193.3 mg). Further, 169 mg of the crude desired product was dissolved in THF (35 mL) and stirred at room temperature for 2 days. The insolubles were filtered off, and the filtrate was concentrated and dried by means of a vacuum pump. After addition of chloroform, the precipitated solid was recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (142.3 mg, yield 75%).
1H-NMR (ppm in DMSO-d6) δ 11.40 (s, 1H), 9.63 (s, 1H), 8.06 (s, 1H), 7.93 (d, J=8.1 Hz, 1H), 7.89 (d, J=8.1 Hz, 1H), 7.55 (ABq, J=8.4 Hz, 2H), 7.50 (ABq, J=8.4 Hz, 2H), 3.85 (s, 3H), 2.45 (s, 3H), 1.33 (s, 9H) LC-MS (ESI) 468 (M+)
Synthetic Example 60
Synthesis of 2-bromo-4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
1) Synthesis of methyl 2-bromo-4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate
1-[5-(4-tert-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.554 mmol, 150.9 mg) synthesized in Synthetic Example 3, methyl 2-bromo-4-hydrazinocarbonylbenzoate (0.554 mmol, 150.8 mg) synthesized in Reference Synthetic Example 42 and p-tosylic acid monohydride (30 mol %, 28.6,mg) were dissolved in isopropyl alcohol (15 mL) and stirred under heating with reflux for 8 hours, and the reactor was cooled to 0° C. The reaction solution was filtered and dried by means of a vacuum pump to give the desired product as a white solid (252.3 mg, yield 86%).
1H-NMR (ppm in DMSO-d6) δ 11.42 (s, 1H), 9.61 (s, 1H), 8.25 (d, J=2.7 Hz, 1H), 8.00 (dd, J=2.7, 8.2 Hz, 1H), 7.89 (d, J=8.2 Hz, 1H), 7.55 (ABq, J=8.4 Hz, 2H), 7.50 (ABq, J=8.4 Hz, 2H), 3.90 (s, 3H), 3.85 (s, 3H), 2.45 (s, 3H), 1.33 (s, 9H) LC-MS (ESI) 526 and 528 (M+)
2) Synthesis of 2-bromo-4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
To methyl 2-bromo-4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate (0.455 mmol, 239.8 mg), methanol (20 mL) was added, and 1 M aqueous sodium hydroxide (2.3 mmol, 2.3 mL) was added. After 5 hours of stirring at 50° C., 14 hours of stirring at room temperature and 4 hours of stirring at 50° C., 1 M hydrochloric acid (2.3 mmol, 2.3 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the crude desired product as a yellow solid (203.8 mg). Further, 178 mg of the crude desired product was dissolved in THF (35 mL) and stirred at room temperature for 2 days. The insolubles were filtered off, and the filtrate was concentrated and dried by means of a vacuum pump. After addition of chloroform, the precipitated solid was recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (150.9 mg, yield 74%).
1H-NMR (ppm in DMSO-d6) δ 11.39 (s, 1H), 9.63 (s, 1H), 8.21 (s, 1H), 7.96 (d, J=8.0 Hz, 1H), 7.83 (d, J=8.0 Hz, 1H), 7.55 (ABq, J=8.7 Hz, 2H), 7.50 (ABq, J=8.7 Hz, 2H), 3.85 (s, 3H), 2.45 (s, 3H), 1.33 (s, 9H) LC-MS (ESI) 512 and 514 (M+)
Synthetic Example 61
Synthesis of 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-hydroxybenzoic acid
1) Synthesis of methyl 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-hydroxybenzoate
1-[5-(4-tert-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.578 mmol, 157.5 mg) synthesized in Synthetic Example 3, methyl 4-hydrazinocarbonyl-2-hydroxybenzoate (0.578 mmol, 121.6 mg) synthesized in Reference Synthetic Example 43 and p-tosylic acid monohydride (30 mol %, 30 mg) were dissolved in isopropyl alcohol (15 mL) and stirred under heating with reflux for 8 hours, and the reactor was cooled to 0° C. The reaction solution was filtered and dried by means of a vacuum pump to give the desired product as a white solid (216.6 mg, yield 81%).
1H-NMR (ppm in DMSO-d6) δ 11.33 (s, 1H), 10.61 (s, 1H), 9.65 (s, 1H), 7.89 (d, J=8.1 Hz, 1H), 7.56-7.43 (multi, 6H), 3.92 (s, 3H), 3.85 (S, 3H), 2.45 and 2.44 (sx2, 3H), 1.33 (s, 9H) LC-MS (ESI) 464 (M+)
2) Synthesis of 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-hydroxybenzoic acid
To methyl 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-hydroxybenzoate (0.438 mmol, 203.3 mg), methanol (20 mL) was added, and 1 M aqueous sodium hydroxide (2.2 mmol, 2.2 mL) was added. After 5 hours of stirring at 50° C., 14 hours of stirring at room temperature and 4 hours of stirring at 50° C., 1 M hydrochloric acid (2.2 mmol, 2.2 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the crude desired product as a yellow solid (175.0 mg). It was further dissolved in THF (35 mL) and stirred at room temperature for 2 days. The insolubles were filtered off, and the filtrate was concentrated and dried by means of a vacuum pump. After addition of chloroform, the precipitated solid was recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (151.6 mg, yield 77%).
1H-NMR (ppm in DMSO-d6) δ 11.30 (s, 1H), 10.61 (s, 1H), 9.66 (s, 1H), 7.90 (d, J=8.1 Hz, 1H), 7.56-7.38 (multi, 6H), 3.85 (s, 3H), 2.44 (s, 3H), 1.33 (s, 9H) LC-MS (ESI) 450 (M+)
Synthetic Example 62
Synthesis of methyl 4-[(2-{1-[5-(3-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate
From 2-(3-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene (100 mg, 0.35 mmol) synthesized in Reference Synthetic Example 49, the desired product was obtained in the same manner as in Synthetic Example 36 as a light brown solid (143 mg, yield 91%).
1H-NMR (ppm in DMSO-6) δ 3.91 (s, 3H), 7.57-7.66 (m, 2H), 7.97-8.20 (m, 7H). LC/MS (ES+) 463.
Synthetic Example 63
Synthesis of 4-[(2-{1-[5-(3-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoic acid
From methyl 4-[(2-{1-[5-(3-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate (120 mg, 0.26 mmol) synthesized in Synthetic Example 62, the desired product was obtained in the same manner as in Synthetic Example 42 as a pale yellow solid (50 mg, yield 43%).
1H-NMR (ppm in DMSO-6) δ 7.58-7.68 (m, 2H), 7.97-8.60 (m, 7H). LC/MS (ES−) 447.
Synthetic Example 64
Synthesis of 4-{[(2-{1-[5-(3-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}benzoic acid
From 2-(3-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene (50 mg, 0.17 mmol) synthesized in Reference Synthetic Example 49, the desired product was obtained in the same manner as in Synthetic Example 51 as a light brown solid (38 mg, 47%).
1H-NMR (ppm in DMSO-6) δ 2.41 (s, 3H), 7.57-8.44 (m, 9H). LC/MS (ES+) 480.
Synthetic Example 65
Synthesis of methyl 2-acetamino-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate
To a suspension of 2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (54.8 mg, 0.2 mmol) and methyl 2-acetamino-4-hydrazinocarbonylbenzoate (50.2 mg, 0.2 mmol) in isopropyl alcohol (2 mL), tosylic acid monohydrate (11.4 mg, 0.06 mmol) was added, and the mixture was heated with reflux for 12 hours. The precipitated solid was filtered to obtain 84 mg of the desired product as a pale yellow solid (yield 83%).
1H-NMR (ppm in DMSO-6) δ 1.29 (s, 9H), 2.13 (s, 3H), 2.49 (s, 3H), 3.86 (s, 3H), 7.42 (d, 2H, J=8.4 Hz), 7.68-7.71 (m, 3H), 7.96-7.98 (m, 2H), 8.53 (s, 1H), 10.54 (brs, 1H), 11.48 (brs, 1H), 12.21 (brs, 1H). LC/MS (ESI) 507 (M+).
Synthetic Example 66
Synthesis of 2-acetamino-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoic acid
To a suspension of methyl 2-acetamino-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}-hydrazino)carbonyl]benzoate (50.8 mg, 0.1 mmol) in isopropyl alcohol (1.0 mL), 0.2 M sodium hydroxide aqueous solution (1.1 mL, 0.22 mmol) was added, and the mixture was stirred at room temperature for 6 hours. After completion of the stirring, 1 M hydrochloric acid (220 μL) was added, and the precipitated solid was filtered and then washed with methanol to obtain 17.5 mg of the desired product as a pale yellow solid (yield 35%).
1H-NMR (ppm in DMSO-d6) δ 1.29 (s, 9H), 2.16 (s, 3H), 2.49 (s, 3H), 7.42 (d, 2H, J=8.4 Hz), 7.64 (d, 1H, J=8.1 Hz), 7.70. (d, 2H, J=8.4 Hz), 7.98 (s, 1H), 8.07 (d, 1H, J=8.1 Hz), 8.87 (s, 1H), 11.05 (brs, 1H), 11.47 (brs, 1H), 12.22 (brs, 1H) LC/MS (ESI) 493 (M+).
Synthetic Example 67
Synthesis of methyl 5-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate
From 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (57.4 mg, 0.2 mmol), methyl 5-hydrazinocarbonyl-2-thiophenecarboxylate (40.0 mg, 0.2 mmol) and tosylic acid monohydrate (11.4 mg, 0.06 mmol), 81.2 mg of the desired product was obtained in the same manner as in Synthetic Example 65 as a pale yellow solid (yield 87%).
1H-NMR (ppm in DMSO-6) δ 3.88 (s, 3H), 7.64-7.71 (m, 2H), 7.91 (d, 1H, J=3.6 Hz), 8.05-8.13 (m, 3H), 11.57 (brs, 1H) LC/MS (ESI) 468, 470 (M+).
Synthetic Example 68
Synthesis of 5-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylic acid
From methyl 5-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate (56.3 mg, 0.12 mmol) and 0.2 M sodium hydroxide aqueous solution (1.89 mL, 0.38 mmol), 7.5 mg of the desired product was obtained in the same manner as in Synthetic Example 66 as a pale yellow solid (yield 14%).
1H-NMR (ppm in DMSO-6) δ=7.64-7.72 (m, 2H), 7.91 (d, 1H, J=3.6 Hz), 8.06-8.14 (m, 3H), 11.54 (brs, 1H). LC/MS (ESI) 454, 456 (M+).
Synthetic Example 69
Synthesis of methyl 5-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate
From 2-(4-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene (57.3 mg, 0.2 mmol), methyl 5-hydrazinocarbonyl-2-thiophenecarboxylate (40.0 mg, 0.2 mmol) and tosylic acid monohydrate (11.4 mg, 0.06 mmol), 68.0 mg of the desired product was obtained in the same manner as in Synthetic Example 65 as a pale yellow solid (yield 73%).
1H-NMR (ppm in DMSO-6) δ 3.86 (s, 3H), 7.75 (d, 2H, J=8.4 Hz), 7.90 (d, 1H, J=4.2 Hz), 7.98 (d, 2H, J=8.4 Hz), 8.08 (d, 1H, J=4.2 Hz), 8.15 (s, 1H), 11.56 (brs, 1H). LC/MS (ESI) 468 (M+).
Synthetic Example 70
Synthesis of 5-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylic acid
To a suspension of methyl 5-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate (56.2 mg, 0.12 mmol) in t-butanol (1.2 mL), 0.2 M sodium hydroxide aqueous solution (1.26 mL, 0.25 mmol) was added, and the mixture was stirred at room temperature for 4 hours. After completion of the stirring, 1 M hydrochloric acid (252 μL) was added, and the precipitated solid was filtered and washed with methanol to obtain 14.9 mg of the desired product as an orange solid (yield 27%).
1H-NMR (ppm in DMSO-6) δ 7.76 (d, 2H, J=8.4 Hz), 7.81 (d, 1H, J=3.9 Hz), 8.00 (d, 2H, J=8.4 Hz), 8.06 (d, 1H, J=3.9 Hz), 8.16 (s, 1H), 11.53 (brs, 1H). LC/MS (ESI) 454 (M+).
Synthetic Example 71
Synthesis of methyl 2-nitro-4-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate
From 2-(4-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene (57.3 mg, 0.2 mmol), methyl 4-hydrazinocarbonyl-2-nitrobenzoate (47.8 mg, 0.2 mmol) and tosylic acid monohydrate (11.4 mg, 0.06 mmol), 81.7 mg of the desired product was obtained in the same manner as in Synthetic Example 65 as a pale yellow solid (yield 81%).
1H-NMR (ppm in DMSO-6) δ=3.89 (s, 3H), 7.75 (d, 2H, J=8.4 Hz), 8.00 (d, 2H, J=8.4 Hz), 8.04 (d, 1H, J=7.8 Hz), 8.17 (s, 1H), 8.35 (d, 1H, J=7.8 Hz), 8.58 (s, 1H), 11.69 (brs, 1H) LC/MS (ESI) 507 (M+).
Synthetic Example 72
Synthesis of 2-nitro-4-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoic acid
From methyl 2-nitro-4-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate (60.9 mg (0.12 mmol) and 0.2 M sodium hydroxide aqueous solution (1.26 mL, 0.25 mmol), 38.2 mg of the desired product was obtained in the same manner as in Synthetic Example 70 as a pale yellow solid (yield 65%).
1H-NMR (ppm in DMSO-6) δ 7.76 (d, 2H, J=8.1 Hz), 8.00-8.05 (m, 3H), 8.18 (s, 1H), 8.31 (d, 1H, J=8.1 Hz), 8.52 (s, 1H), 11.68 (brs, 1H). LC/MS (ESI) 493 (M+).
Synthetic Example 73
Synthesis of methyl 2-fluoro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate
From 2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (59.0 mg, 0.215 mmol), methyl 2-fluoro-4-hydrazinocarbonylbenzoate (45.6 mg, 0.215 mmol) and tosylic acid monohydrate (12.3 mg, 0.0645 mmol), 94.9 mg of the desired product was obtained in the same manner as in Synthetic Example 65 as a pale yellow solid (yield 94%).
1H-NMR (ppm in DMSO-6) δ 1.29 (s, 9H), 3.91 (s, 3H), 7.43 (d, 2H, J=8.4 Hz), 7.71 (d, 2H, J=8.4 Hz), 7.85-7.94 (m, 2H), 8.01-8.08 (m, 2H), 11.50 (brs, 1H), 12.17 (brs, 1H). LC/MS (ESI) 468 (M+).
Synthetic Example 74
Synthesis of 2-fluoro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoic acid
From methyl 2-fluoro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate (56.2 mg, 0.12 mmol) and 0.2 M sodium hydroxide aqueous solution (1.26 mL, 0.25 mmol), 46.3 mg of the desired product was obtained in the same manner as in Synthetic Example 70 as a pale yellow solid (yield 85%).
1H-NMR (ppm in DMSO-6) δ 1.29 (s, 9H), 7.43 (d, 2H, J=8.4 Hz), 7.71 (d, 2H, J=8.4 Hz), 7.83-7.94 (m, 2H), 7.99-8.04 (m, 2H), 11.48 (brs, 1H), 12.18 (brs, 1H). LC/MS (ESI) 452 (M+).
Synthetic Example 75
Synthesis of methyl 4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl](isopropyl)methylene}hydrazino)-carbonyl]benzoate
A suspension of 2-(4-t-butylphenyl)-3-hydroxy-4-isopropylcarbonylthiophene (100 mg, 0.33 mmol), 4-hydrazinocarbonylmethylbenzoate (70 mg, 0.36 mmol) and p-tosylic acid monohydrate in isopropyl alcohol, was dehydrated with reflux for 2 days. After completion of the reaction, the reaction solution was cooled to room temperature and filtered to obtain the desired product as a yellow solid (92 mg, yield 58%).
1H-NMR (ppm in DMSO-6) δ 1.30 (s, 9H), 1.38 (s, 3H), 1.41 (s, 3H), 3.91 (s, 3H), 7.43 (d, J=8.3 Hz, 2H), 7.71 (d, J=8.3 Hz, 2H), 8.02-8.13 (m, 5H). LC/MS (ES+) 479.
Synthetic Example 76
Synthesis of 4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl](isopropyl)methylene}hydrazino)carbonyl]benzoic acid
Using methyl 4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl](isopropyl)methylene}-hydrazino)carbonyl]benzoate (80 mg, 0.17 mmol) as the starting material, the desired product was obtained in the same manner as in Synthetic Example 70 as a pale yellow solid (19 mg, yield 24%).
1H-NMR (ppm in DMSO-6) δ 1.30 (s, 9H), 1.39-1.41 (m, 6H), 7.42-7.44 (m, 2H), 7.70-7.73 (m, 2H), 8.00-8.10 (m, 6H). LC/MS (ES+) 465.
Synthetic Example 77
Synthesis of methyl 2-nitro-4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate
Using 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (100 mg, 0.35 mmol) and methyl 2-nitro-4-hydrazinocarbonylbenzoate (93 mg, 0.39 mmol) as the starting materials, the desired product was obtained in the same manner as in Synthetic Example 65 as a yellow solid (147 mg, yield 83%).
1H-NMR (ppm in DMSO-6) δ 3.91 (s, 3H), 7.55-7.75 (m, 2H), 8.05-8.20 (m, 3H), 8.30-8.40 (m, 1H), 8.50-8.65 (m, 1H). LC/MS (ES−) 507.
Synthetic Example 78
Synthesis of 2-nitro-4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoic acid
Using methyl 2-nitro-4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate (137 mg, 0.27 mmol) as the starting material, the desired product was obtained in the same manner as in Synthetic Example 66 as a yellow solid (68 mg, yield 51%).
LC/MS (ES+) 494, 495.
Synthetic Example 79
Synthesis of methyl 2-bromo-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate
Using 2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (55 mg, 0.20 mmol) and methyl 2-bromo-4-hydrazinocarbonylbenzoate (60 mg, 0.22 mmol) as the starting materials, the desired product was obtained in the same manner as in Synthetic Example 65 as a yellow solid (92 mg, yield 87%).
1H-NMR (ppm in DMSO-6) δ 1.30 (s, 9H), 3.91 (s, 3H), 7.43 (d, J=8.5 Hz, 2H), 7.71 (d, J=8.5 Hz, 2H), 7.91 (d, J=8.0 Hz, 1H), 8.01-8.03 (m, 2H), 8.27 (s, 1H). LC/MS (ES−) 528.
Synthetic Example 80
Synthesis of 2-bromo-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoic acid
Using methyl 2-bromo-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate (82 mg, 0.15 mmol) as the starting material, the desired product was obtained in the same manner as in Synthetic Example 66 as a yellow solid (67 mg, yield 87%).
1H-NMR (ppm in DMSO-6) δ 1.31 (s, 9H), 7.43 (d, J=8.4 Hz, 2H), 7.71 (d, J=8.4 Hz, 2H), 7.87-7.89 (m, 1H), 7.97-8.01 (m, 2H), 8.24 (s, 1H). LC/MS (ES+) 517, 519.
Synthetic Example 81
Synthesis of methyl 2-chloro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate
Using 2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (55 mg, 0.20 mmol) and methyl 2-chloro-4-hydrazinocarbonylbenzoate (50 mg, 0.22 mmol) as the starting materials, the desired product was obtained in the same manner as in Synthetic Example 65 as a pale yellow solid (86 mg, yield 89%).
1H-NMR (ppm in DMSO-6) δ 1.30 (s, 9H), 3.91 (s, 3H), 7.43 (d, J=8.4 Hz, 2H), 7.71 (d, J=8.5 Hz, 2H), 7.97-8.01 (m, 3H), 8.12 (s, 1H). LC/MS (ES−) 483, 485.
Synthetic Example 82
Synthesis of 2-chloro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoic acid
Using methyl 2-chloro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonyl]benzoate (76 mg, 0.16 mmol) as the starting material, the desired product was obtained in the same manner as in Synthetic Example 66 as a pale yellow solid (60 mg, yield 80%).
LC/MS (ES+) 471, 473.
Synthetic Example 83
Synthesis of methyl 4-[(2-{1-[2-bromo-5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate
To a suspension of 2-bromo-5-(4-t-butylphenyl)-4-hydroxy-3-methylcarbonylthiophene (1.00 g, 2.83 mmol) synthesized in Reference Synthetic Example 55 and 4-hydrazinocarbonylmethylbenzoate (550 mg, 2.83 mmol) in isopropyl alcohol (28.3 mL), tosylic acid monohydrate (146 mg, 0.85 mmol) was added, and the mixture was heated with reflux for about 1 hour. The reaction solution was concentrated, and then purified with a silica gel column chromatography (chloroform, and then chloroform/ethyl acetate=95/5) to obtain the desired product as a yellow solid (935 mg, yield 62%).
1H-NMR (ppm in DMSO-6) δ 1.29 (s, 9H), 2.61 (s, 3H), 3.91 (s, 3H), 7.44 (d, J=8.4 Hz, 2H), 7.65 (d, J=8.4 Hz, 2H), 8.06-8.14 (m, 4H), 11.69 (s, 1H), 12.29 (s, 1H). LC/MS (ES+) 529, 531.
Synthetic Example 84
Synthesis of methyl 4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-nitrobenzoate
From 1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.70 mmol, 200 mg) synthesized in Synthetic Example 1, methyl 2-nitro-4-hydrazinocarbonylbenzoate (0.70 mmol, 167.8 mg) of Reference Synthetic Example 40 and tosylic acid monohydrate (36.2 mg, 0.21 mmol), 311.1 mg of the desired product was obtained in the same manner as in Synthetic Example 58 as a yellow solid (yield 88%).
1H-NMR (ppm in DMSO-d6) δ 11.61 (s, 1H), 9.85 (s, 1H), 8.58 (d, J=1.4 Hz, 1H), 8.34 (dd, J=1.4, 8.0 Hz, 1H), 8.04 (d, J=8.0 Hz, 1H), 7.86 (d, J=1.9 Hz, 2H), 7.80 (d, J=8.4 Hz, 1H), 7.61 (dd, J=1.9, 8.4 Hz, 1H), 3.90 (s, 6H), 2.46 (s, 3H). LC-MS (ESI) 505 (M+)
Synthetic Example 85
Synthesis of 4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-nitrobenzoic acid
From methyl 4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-nitrobenzoate (0.40 mmol, 200 mg) and 1 M sodium hydroxide aqueous solution (1.98 mL, 1.98 mmol), 130.5 mg of the desired product was obtained in the same manner as in Synthetic Example 58 as a yellow solid (yield 67%).
1H-NMR (ppm in DMSO-d6) δ 11.58 (s, 1H), 9.86 (s, 1H), 8.50 (s, 1H), 8.27-8.32 (m, 1H), 8.01 (d, J=8.0 Hz, 1H), 7.85-7.86 (m, 1H), 7.80 (d, J=8.5 Hz, 1H), 7.60-7.62 (m, 1H), 3.90 (s, 3H), 2.46 (S, 3H). LC-MS (ESI) 491 (M+)
Synthetic Example 86
Synthesis of methyl 4-{[2-(1-[4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl]ethylidene)hydrazino]carbonyl}-2-nitrobenzoate
From 1-[4-hydroxy-1-methyl-5-(4-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethanone (0.70 mmol, 200 mg) synthesized in Synthetic Example 11, methyl 2-nitro-4-hydrazinocarbonylbenzoate (0.70 mmol, 168.3 mg) of Reference Synthetic Example 40 and tosylic acid monohydrate (36.4 mg, 0.21 mmol), 214.7 mg of the desired product was obtained in the same manner as in Synthetic Example 58 as a yellow solid (yield 60%).
1H-NMR (ppm in DMSO-d6) δ 11.62 (s, 1H), 9.88 (s, 1H), 8.58 (d, J=1.5 Hz, 1H), 8.35 (dd, J=1.5, 8.0 Hz, 1H), 8.05 (d, J=8.0 Hz, 1H), 7.90 (ABq, J=8.7 Hz, 2H), 7.84 (ABq, J=8.7 Hz, 2H), 3.93 (s, 3H), 3.90 (s, 3H), 2.48 (s, 3H). LC-MS (ESI) 505 (M+)
Synthetic Example 87
Synthesis of 4-{[2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}-2-nitrobenzoic acid
From methyl 4-{[2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}-2-nitrobenzoate (0.30 mmol, 150 mg) and 1 M sodium hydroxide aqueous solution (1.48 mL, 1.48 mmol), 106.0 mg of the desired product was obtained in the same manner as in Synthetic Example 58 as a pale yellow solid (yield 73%).
1H-NMR (ppm in DMSO-d6) δ 11.59 (s, 1H), 9.88 (s, 1H), 8.50 (s, 1H), 8.28-8.31 (m, 1H), 8.02 (d, J=8.0 Hz, 1H), 7.90 (ABq, J=8.7 Hz, 2H), 7.84 (ABq, J=8.7 Hz, 2H), 3.93 (s, 3H), 2.47 (s, 3H). LC-MS (ESI) 491 (M+).
Synthetic Example 88
Synthesis of methyl 5-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate
From 1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (200 mg, 0.70 mmol) synthesized in Synthetic Example 1, methyl 5-hydrazinocarbonyl-2-thiophenecarboxylate (0.70 mmol, 140.4 mg) of Reference Synthetic Example 39 and tosylic acid monohydrate (36.2 mg, 0.21 mmol), 314.1 mg of the desired product was obtained in the same manner as in Synthetic Example 58 as a yellow solid (yield 96%).
1H-NMR (ppm in DMSO-d6) δ 11.47 (s, 1H), 9.76 (s, 1H), 8.04-8.07 (m, 1H), 7.79-7.91 (m, 3H), 7.56-7.61 (s, 1H), 3.87 (s, 6H), 2.46 (s, 3H). LC-MS (ESI) 466 (M+).
Synthetic Example 89
Synthesis of 5-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylic acid
From methyl 5-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate (200 mg, 0.43 mmol) and 1 M sodium hydroxide aqueous solution (2.13 mL, 2.13 mmol), 153.3 mg of the desired product was obtained in the same manner as in Synthetic Example 58 as a yellow solid (yield 84%).
1H-NMR (ppm in DMSO-d6) δ 11.43 (s, 1H), 9.78 (s, 1H), 8.03-8.32 (m, 1H), 7.79-7.85 (m, 3H), 7.58-7.61 (m, 1H), 3.89 (s, 3H), 2.46 (s, 3H). LC-MS (ESI) 452 (M+).
Synthetic Example 90
Synthesis of methyl 5-{[2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}-2-thiophenecarboxylate
From 1-[4-hydroxy-1-methyl-5-(4-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethanone (200 mg, 0.70 mmol) synthesized in Synthetic Example 11, methyl 5-hydrazinocarbonyl-2-thiophenecarboxylate (0.70 mmol, 140.9 mg) of Reference Synthetic Example 39 and tosylic acid monohydrate (36.4 mg, 0.21 mmol), 188.2 mg of the desired product was obtained in the same manner as in Synthetic Example 58 as a pale yellow solid (yield 57%).
1H-NMR (ppm in DMSO-d6) δ 11.48 (s, 1H), 9.78 (s, 1H), 8.06-8.08 (m, 1H), 7.82-7.91 (m, 5H), 3.92 (s, 3H), 3.87 (s, 3H), 2.47 (s, 3H). LC-MS (ESI) 466 (M+)
Synthetic Example 91
Synthesis of 5-{[2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}-2-thiophenecarboxylic acid
From methyl 5-{[2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}-2-thiophenecarboxylate (150 mg, 0.32 mmol) and 1 M sodium hydroxide aqueous solution (1.60 mL, 1.60 mmol), 89.0 mg of the desired product was obtained in the same manner as in Synthetic Example 58 as a pale yellow solid (yield 61%).
1H-NMR (ppm in DMSO-d6) δ 11.44 (s, 1H), 9.80 (s, 1H), 8.03-8.04 (m, 1H), 7.80-7.91 (m, 5H), 3.92 (s, 3H), 2.47 (s, 3H). LC-MS (ESI) 452 (M+).
Synthetic Example 92
Synthesis of methyl 4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoate
Dimethylformamide (1.3 mL) and conc. hydrochloric acid (1 drop) were added to 2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (71 mg, 0.26 mmol) synthesized in Reference Synthetic Example 33 and methyl 4-hydrazinocarbonothioylamino-2-nitrobenzoate (70 mg, 0.26 mmol) synthesized in Reference Synthetic Example 56, and the mixture was stirred at room temperature for 2 days. The precipitated solid was filtered to obtain 110 mg of the desired product as a pale yellow solid (yield 81%).
1H-NMR (ppm in DMSO-d6) δ 11.29 (bs, 1H), 10.67 (bs, 1H), 8.57 (bs, 1H), 7.87-8.03 (m, 3H), 7.67 (d, J=8.4 Hz, 2H), 7.41 (d, J=8.4 Hz, 2H), 3.83 (s, 3H), 2.40 (s, 3H), 1.28 (s, 9H). LC/MS (ESI) 526.
Synthetic Example 93
Synthesis of 4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-nitrobenzoic acid
Methyl 4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-nitrobenzoate (95 mg, 0.18 mmol) synthesized in Synthetic Example 92 was dissolved in isopropyl alcohol (1.8 mL), and 0.2 M sodium hydroxide aqueous solution (2.0 mL, 0.40 mmol) was added thereto, followed by stirring overnight at room temperature. After completion of the stirring, 1 M hydrochloric acid (0.40 mL, 0.40 mmol) and water were added thereto, and the precipitated solid was filtered to obtain 57 mg of the desired product as a pale yellow solid (yield 61%).
1H-NMR (ppm in DMSO-d6) δ 11.29 (bs, 1H), 10.64 (bs, 1H), 8.50 (bs, 1H), 7.87-8.00 (m, 3H), 7.69 (d, J=8.4 Hz, 2H), 7.43 (d, J=8.4 Hz, 2H), 2.41 (s, 3H), 1.29 (s, 9H). LC/MS (ESI) 512.
Synthetic Example 94
Synthesis of methyl 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoate
From 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (60 mg, 0.21 mmol) synthesized in Reference Synthetic Example 34, the desired product was obtained in the same manner as in Synthetic Example 92 as a yellow solid (88 mg, yield 78%).
1H-NMR (ppm in DMSO) δ 11.35 (bs, 1H), 10.70 (bs, 1H), 8.57 (bs, 1H), 8.14 (s, 1H), 8.01-8.04 (m, 2H), 7.89-7.91 (m, 1H), 7.65-7.74 (m, 2H), 3.84 (s, 3H), 2.42 (s, 3H). LC/MS (ESI) 538.
Synthetic Example 95
Synthesis of 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-nitrobenzoic acid
From methyl 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoate (70 mg, 0.13 mmol) synthesized in Synthetic Example 94, the desired product was obtained in the same manner as in Synthetic Example 93 as a pale yellow solid (43 mg, yield 63%).
1H-NMR (ppm in DMSO) δ 11.32 (bs, 1H), 10.66 (bs, 1H), 8.48 (bs, 1H), 8.13 (s, 1H), 7.87-8.02 (m, 3H), 7.64-7.74 (m, 2H), 2.41 (s, 3H). LC/MS (ESI) 524.
Synthetic Example 96
Synthesis of methyl 4-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-nitrobenzoate
From 2-(4-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene (60 mg, 0.21 mmol) synthesized in Reference Synthetic Example 35, the desired product was obtained in the same manner as in Synthetic Example 92 as a yellow solid (103 mg, yield 91%).
1H-NMR (ppm in DMSO) δ 11.36 (bs, 1H), 10.72 (bs, 1H), 8.58 (bs, 1H), 8.17 (s, 1H), 7.89-8.04 (m, 4H), 7.76 (d, J=8.3 Hz, 2H), 3.84 (s, 3H), 2.43 (s, 3H) LC/MS (ESI) 538.
Synthetic Example 97
Synthesis of 4-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]-amino}-2-nitrobenzoic acid
From methyl 4-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoate (90 mg, 0.17 mmol) synthesized in Synthetic Example 96, the desired product was obtained in the same manner as in Synthetic Example 93 as a pale yellow solid (69 mg, yield 79%).
1H-NMR (ppm in DMSO) δ 11.34 (bs, 1H), 10.65-10.67 (m, 1H), 8.49 (bs, 1H), 8.16 (s, 1H), 7.88-8.01 (m, 4H), 7.76 (d, J=8.5 Hz, 2H), 2.43 (s, 3H). LC/MS (ESI) 524.
Synthetic Example 98
Synthesis of methyl 5-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}-2-thiophenecarboxylate
Dimethylformamide (1.3 ml) and conc. hydrochloric acid (1 drop) were added to 2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (70 mg, 0.26 mmol) synthesized in Reference Synthetic Example 33 and methyl 5-hydrazinocarbonothioylamino-2-thiophenecarboxylate (59 mg, 0.26 mmol) synthesized in Reference Synthetic Example 57, and the mixture was stirred overnight at room temperature. Water was added, and the precipitated solid was filtered. The obtained solid was extracted with chloroform, dried over anhydrous sodium sulfate. The organic layer was concentrated, and purified with a silica gel column chromoatography (chloroform/methanol=95/5) to obtain the desired product as a pale yellow solid (112 mg, yield 90%).
1H-NMR (ppm in DMSO) δ 11.63 (bs, 1H), 11.18 (bs, 1H), 8.01 (bs, 1H), 7.72 (d, J=8.5 Hz, 2H), 7.67 (d, J=4.4 Hz, 1H), 7.46 (d, J=8.5 Hz, 2H), 6.92 (d, J=4.4 Hz, 1H), 3.82 (s, 3H), 2.41 (s, 3H), 1.32 (s, 9H) LC/MS (ESI) 487.
Synthetic Example 99
Synthesis of 5-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-thiophenecarboxylic acid
Methyl S-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-thiophenecarboxylate (85 mg, 0.18 mmol) synthesized in Synthetic Example 98 was dissolved in isopropyl alcohol (1.8 ml), and 0.2 M sodium hydroxide aqueous solution (1.95 ml, 0.39 mmol) was added thereto, following by stirring overnight at room temperature. Then 0.2 M sodium hydroxide aqueous solution (0.96 ml, 0.19 mmol) was added thereto, following by stirring overnight at 45° C. After completion of the stirring, 1 M hydrochloric acid (0.58 ml, 0.58 mmol) was added. The precipitated solid was filtered to obtain 2.7 mg of the desired product as a pale yellow solid (yield 3%).
LC/MS (ESI) 473.
Synthetic Example 100
Synthesis of methyl 4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}-2-chlorobenzoate
From 2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (60 mg, 0.22 mmol) synthesized in Reference Synthetic Example 33, the desired product was obtained in the same manner as in Synthetic Example 92 as a yellow solid (118 mg, yield 100%).
1H-NMR (ppm in DMSO) δ 11.21 (bs, 1H), 10.50 (bs, 1H), 8.21 (bs, 1H), 7.97 (d, J=8.5 Hz, 1H), 7.89 (d, J=8.5 Hz, 1H), 7.68-7.71 (m, 3H), 7.43 (d, J=8.3 Hz, 2H), 3.85 (s, 3H), 2.40 (s, 3H), 1.29 (s, 9H). LC/MS (ESI) 515.
Synthetic Example 101
Synthesis of 4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-chlorobenzoic acid
Methyl 4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-chlorobenzoate (100 mg, 0.19 mmol) synthesized in Synthetic Example 100 was dissolved in isopropyl alcohol (1.9 ml), and 0.2 M sodium hydroxide aqueous solution (2.1 ml, 0.42 mmol) was added thereto, following by stirring overnight at room temperature, then at 45° C. for 1 day. Then 0.2 M sodium hydroxide aqueous solution (1.1 ml, 0.22 mmol) was added thereto, following by stirring at 45° C. for 5.5 hours. After completion of the stirring, 1 M hydrochloric acid (0.64 ml, 0.64 mmol) was added. The precipitated solid was filtered, and purified with a silica gel plate (chloroform/methanol=9/1) to obtain the desired product as a yellow solid (24 mg, yield 25%).
1H-NMR (ppm in DMSO) δ 10.48 (bs, 1H), 8.18 (bs, 1H), 7.84-7.94 (m, 2H), 7.65-7.68 (m, 3H), 7.40-7.43 (m, 2H), 2.41 (s, 3H), 1.29 (s, 9H). LC/MS (ESI) 501.
Synthetic Example 102
Synthesis of methyl 4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}-2-nitrobenzoate
From 1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (63 mg, 0.23 mmol) synthesized in Synthetic Example 3, the desired product was obtained in the same manner as in Synthetic Example 92 as a yellow solid (121 mg, yield 100%).
1H-NMR (ppm in DMSO) δ 10.53 (bs, 1H), 8.60-8.61 (m, 1H), 7.87-8.06 (m, 2H), 7.47-7.60 (m, 4H), 3.84 (s, 3H), 3.82 (s, 3H), 2.41 (s, 3H), 1.33 (s, 9H). LC/MS (ESI) 524.
Synthetic Example 103
Synthesis of 4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoic acid
Methyl 4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoate (100 mg, 0.19 mmol) synthesized in Synthetic Example 102 was dissolved in methanol (6.7 ml), and 1 M sodium hydroxide aqueous solution (0.96 ml, 0.96 mmol) was added thereto, following by stirring overnight at room temperature. After completion of the stirring, the reaction solution was washed with ethyl acetate, and to the aqueous layer, 1 M hydrochloric acid was added. The precipitated solid was filtered to obtain 27 mg of the desired product as a pale yellow solid (yield 28%).
1H-NMR (ppm in DMSO) δ 11.10 (bs, 1H), 10.50 (bs, 1H), 8.49 (bs, 1H), 7.86-7.97 (m, 2H), 7.47-7.59 (m, 4H), 3.82-3.83 (m, 3H), 2.41 (S, 3H), 1.33-1.34 (m, 9H). LC/MS (ESI) 510.
Synthetic Example 104
Synthesis of methyl 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}-hydrazino)carbonothioyl]amino}-2-nitrobenzoate
Dimethylformamide (1 ml) and conc. hydrochloric acid (1 drop) were added to 1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (60 mg, 0.21 mmol) synthesized in Synthetic Example 1 and methyl 4-hydrazinocarbonothioylamino-2-nitrobenzoate (57 mg, 0.21 mmol) synthesized in Reference Synthetic Example 56, and the mixture was stirred at room temperature for 21 hours. Water was added, and the precipitated solid was filtered, purified with a silica gel column chromoatography (n-hexane/ethyl acetate=1/1 then chloroform/methanol=95/5). The obtained solid was extracted with ethyl acetate, washed with a saturated ammonium chloride aqueous solution, saturated sodium chloride aqueous solution. The organic layer was concentrated to obtain the desired product as a pale yellow solid (104 mg, yield 92%).
1H-NMR (ppm in DMSO) δ 8.57 (bs, 1H), 8.03-8.05 (m, 1H), 7.78-7.90 (m, 3H), 7.56-7.59 (m, 1H), 3.86 (s, 3H), 3.84 (s, 3H), 2.41 (s, 3H). LC/MS (ESI) 536.
Synthetic Example 105
Synthesis of 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoic acid
Methyl 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoate (100 mg, 0.19 mmol) synthesized in Synthetic Example 104 was dissolved in methanol (3 ml), and 1 M sodium hydroxide aqueous solution (0.74 ml, 0.74 mmol) was added thereto, following by stirring overnight at room temperature. After completion of the stirring, 1 M hydrochloric acid (0.74 ml, 0.74 mmol) and water were added thereto. The precipitated solid was recovered by filtration, washed with water, isopropyl alcohol, and chloroform. The obtained solid was stirred in chlorororm, and then filtered to obtain 37 mg of the desired product as a yellow solid (yield 48%).
1H-NMR (ppm in DMSO) δ 8.47 (bs, 1H), 7.77-7.93 (m, 4H), 7.56-7.59 (m, 1H), 3.86 (s, 3H), 2.42 (s, 3H) LC/MS (ESI) 522.
Synthetic Example 106
Synthesis of 4-{[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoic acid
From 1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone, synthesized in the same manner as in Synthetic Example 1, the desired product was obtained in the same manner as in Synthetic Examples 102 and 103 as a yellow solid (22.6 mg).
1H-NMR (ppm in DMSO) δ 8.48 (bs, 1H), 7.50-8.00 (m, 6H), 3.88 (s, 3H), 2.42 (s, 3H). LC/MS (ESI) 488
Synthetic Example 107
Synthesis of 4-[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-nitrobenzoic acid
From 1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone synthesized in the same manner as in Synthetic Example 1, the desired product was obtained in the same manner as in Synthetic Example 58 as a pale yellow solid (19.1 mg).
1H-NMR (ppm in DMSO) δ 11.5 (1H, s), 9.73 (1H, s), 8.49 (1H, s), 8.28 (1H, d, J=8 Hz), 8.01 (1H, d, J=8 Hz), 7.65-7.55 (4H, m), 3.87 (3H, s), 2.46 (3H, s). LC/MS (ESI) 457
Synthetic Example 108
Synthesis of 5-[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylic acid
From 1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone synthesized in the same manner as in Synthetic Example 1, the desired product was obtained in the same manner as in Synthetic Examples 33 and 34 as a yellow solid (20.2 mg).
1H-NMR (ppm in DMSO) δ 11.4 (1H, s), 9.64 (1H, s), 8.02 (1H, d, J=3 Hz), 7.80 (1H, d, J=3 Hz), 7.5-7.7 (4H, m), 3.86 (3H, s), 2.45 (3H, s). LC/MS (ESI) 418
Synthetic Example 109
Synthesis of 4-[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
From 1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone synthesized in the same manner as in Synthetic Example 1, the desired product was obtained in the same manner as in Synthetic Example 3 as a yellow solid (47.4 mg).
1H-NMR (ppm in DMSO) δ 11.4 (1H, s), 9.83 (1H, s), 7.90-8.20 (4H, m), 7.50-7.70 (4H, m), 3.86 (3H, s), 2.45 (3H, s). LC/MS (ESI) 412
Synthetic Example 110
Synthesis of 4-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoic acid
From methyl 4-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}-2-nitrobenzoate (70 mg, 0.13 mmol), the desired product was obtained in the same manner as in Synthetic Examples 104 and 105 as a yellow solid (42 mg, yield 62%).
1H-NMR (ppm in DMSO) δ 8.48 (bs, 1H), 7.80-8.00 (m, 6H), 3.88 (s, 3H), 2.42 (s, 3H). LC/MS (ESI) 522.
Synthetic Example 111
Synthesis of 4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-chlorobenzoic acid
From methyl 4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}-2-chlorobenzoate (82 mg, 0.16 mmol), the desired product was obtained in the same manner as in Synthetic Examples 104 and 105 as a brown solid (40 mg, yield 50%).
1H-NMR (ppm in DMSO) δ 8.12-8.26 (m, 1H), 7.50-7.81 (m, 6H), 3.82 (s, 3H), 2.41 (s, 3H), 1.32 (s, 9H). LC/MS (ESI) 499.
Synthetic Example 112
Synthesis of 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-chlorobenzoic acid
From methyl 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}-2-chlorobenzoate (105 mg, 0.20 mmol), the desired product was obtained in the same manner as in Synthetic Examples 104 and 105 as a pale yellow solid (54 mg, yield 52%).
1H-NMR (ppm in DMSO) δ 8.09 (bs, 1H), 7.77-7.85 (m, 3H), 7.65-7.68 (m, 1H), 7.55-7.58 (m, 1H), 3.84 (s, 3H), 2.39 (s, 3H). LC/MS (ESI) 511.
Synthetic Example 113
Synthesis of 4-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-chlorobenzoic acid
From methyl 4-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}-2-chlorobenzoate (60 mg, 0.11 mmol), the desired product was obtained in the same manner as in Synthetic Examples 104 and 105 as a pale yellow solid (25 mg, yield 42%).
1H-NMR (ppm in DMSO) δ 8.11 (bs, 1H), 7.80-7.94 (m, 5H), 7.67-7.70 (m, 1H), 3.88 (s, 3H), 2.41 (s, 3H). LC/MS (ESI) 511.
Synthetic Example 114
Synthesis of 5-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-thiophenecarboxylic acid
1) Synthesis of 5-hydrazinocabonothioylamino-2-thiophenecarboxylic acid
To methyl 5-hydrazinocabonothioylamino-2-thiophenecarboxylate (1.21 mmol, 280 mg) obtained in Reference Synthetic Example 57, methanol (2.4 ml) was added, and 0.2 M aqueous sodium-hydroxide (3 eq, 18.2 ml) was added at room temperature. After stirring of 1.5 hours at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (3 eq, 3.63 ml) was added. The precipitated solid was recovered by filtration, washed with water and chloroform and dried by means of a vacuum pump. The desired product was obtained as a pale yellow solid (230 mg, yield 87.6% (LC purity 90%)).
1H-NMR (ppm in DMSO) δ 9.56 (bs, 1H), 7.47 (d, J=4.1 Hz, 1H), 7.07 (bs, 1H), 6.91 (bs, 1H). LC/MS (ESI) 217.
2) Synthesis of 5-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-thiophenecarboxylic acid
From 1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (40.0 mg, 0.15 mmol) and 5-hydrazinocabonothioylamino-2-thiophenecarboxylic acid (35.5 mg, 0.15 mmol), the desired product was obtained in the same manner as in Synthetic Example 2 as a yellow solid (57.3 mg, yield 83%).
1H-NMR (ppm in DMSO) δ 7.47-7.56 (m, 5H), 6.90 (bs, 1H), 3.82 (s, 3H), 2.39 (S, 3H), 1.34 (s, 9H) LC/MS (ESI) 471.
Synthetic Example 115
Synthesis of 5-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-thiophenecarboxylic acid
From 1-[S-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (40.0 mg, 0.14 mmol) and 5-hydrazinocabonothioylamino-2-thiophenecarboxylic acid (33.9 mg, 0.14 mmol), the desired product was obtained in the same manner as in Synthetic Example 114 as a pale yellow solid (62.2 mg, yield 92%).
1H-NMR (ppm in DMSO) δ 7.84 (d, J=1.7 Hz, 1H), 7.80 (d, J=8.3 Hz, 1H), 7.54-7.60 (m, 2H), 6.90 (bs, 1H), 3.86 (s, 3H), 2.39 (s, 3H). LC/MS (ESI) 483.
Synthetic Example 116
Synthesis of 5-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-thiophenecarboxylic acid
From 1-[5-(4-trifluoromethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (40.0 mg, 0.14 mmol) and 5-hydrazinocabonothioylamino-2-thiophenecarboxylic acid (34.0 mg, 0.14 mmol), the desired product was obtained in the same manner as in Synthetic Example 114 as a pale yellow solid (55.8 mg, yield 82%).
1H-NMR (ppm in DMSO) δ 7.81-7.91 (m, 4H), 7.55 (d, J=4.1 Hz, 1H), 6.90 (bs, 1H), 3.89 (s, 3H), 2.40 (s, 3H). LC/MS (ESI) 483.
Synthetic Example 117
Synthesis of 5-{[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-thiophenecarboxylic acid
From 1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (37.5 mg, 0.15 mmol) and 5-hydrazinocabonothioylamino-2-thiophenecarboxylic acid (33 mg, 0.14 mmol), the desired product was obtained in the same manner as in Synthetic Example 114 as a pale yellow solid (62.0 mg, yield 83%).
1H-NMR (ppm in DMSO) δ 7.45-7.56 (m, 5H), 6.94 (bs, 1H), 3.87 (s, 3H), 2.43 (s, 3H). LC/MS (ESI) 449.
Synthetic Example 118
Synthesis of 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-chlorobenzoic acid
1) Synthesis of 4-hydrazinocabonothioylamino-2-chlorobenzoic acid
To methyl 4-hydrazinocabonothioylamino-2-chlorobenzoate (1.16 mmol, 300 mg) obtained in Reference Synthetic Example 58, methanol (2.3 ml) was added, and 0.2 M aqueous sodium hydroxide (2.1 eq, 12.1 ml) was added at room temperature. After stirring of 1.5 hours at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (2.1 eq, 2.43 ml) was added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump. 4-Hydrazinocabonothioylamino-2-chlorobenzoic acid was obtained as a colorless solid (262.8 mg, yield 92.6%).
1H-NMR (ppm in DMSO) δ 9.48 (bs, 1H), 8.22 (bs, 1H), 7.75-7.77 (m, 3H). LC/MS (ESI) 245.
2) Synthesis of 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}-2-chlorobenzoic acid
From 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (50 mg, 0.17 mmol) and 4-hydrazinocabonothioylamino-2-chlorobenzoic acid (42.8 mg, 0.17 mmol)., the desired product was obtained in the same manner as in Synthetic Example 50 as a pale yellow solid. (61.1 mg, yield 68%).
1H-NMR (ppm in DMSO) δ 11.20 (bs, 1H), 10.46 (bs, 1H), 8.14 (bs, 1H), 8.11 (s, 1H), 8.02 (d, J=1.9 Hz, 1H), 7.87 (d, J=8.5 Hz, 1H), 7.64-7.74 (m, 3H), 2.40 (s, 3H). LC/MS (ESI) 513.
Synthetic Example 119
Synthesis of 4-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}-2-chlorobenzoic acid
From 2-(4-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene (50.0 mg, 0.17 mmol) and 4-hydrazinocabonothioylamino-2-chlorobenzoic acid (42.9 mg, 0.17 mmol), the desired product was obtained in the same manner as in Synthetic Example 118 as a pale yellow solid (58.3 mg, yield 65%).
1H-NMR (ppm in DMSO) δ 11.22 (bs, 1H), 10.47 (bs, 1H), 8.13-8.15 (m, 2H), 8.00 (d, J=8.3 Hz, 2H), 7.87 (d, J=8.5 Hz, 1H), 7.76 (d, J=8.3 Hz, 2H), 7.65-7.68 (m, 1H), 2.41 (s, 3H). LC/MS (ESI) 513.
Synthetic Example 120
Synthesis of 4-{[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-chlorobenzoic acid
From 1-[5-(4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (37.5 mg, 0.15 mmol) and 4-hydrazinocabonothioylamino-2-chlorobenzoic acid (36.9 mg, 0.15 mmol), the desired product was obtained in the same manner as in Synthetic Example 114 as a yellow solid (59.5 mg, yield 92%).
1H-NMR (ppm in DMSO) δ 7.40-8.40 (m, 7H), 3.78-3.84 (m, 3H), 2.40 (s, 3H). LC/MS (ESI) 477.
Synthetic Example 121
Synthesis of 5-{[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-thiophenecarboxylic acid
From 2-(4-chlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (25.3 mg, 0.10 mmol) and 5-hydrazinocabonothioylamino-2-thiophenecarboxylic acid (21.8 mg, 0.10 mmol), the desired product was obtained in the same manner as in Synthetic Example 50 as a pale yellow solid (37.1 mg, yield 82%).
1H-NMR (ppm in DMSO) δ 11.54 (bs, 1H), 11.13 (bs, 1H), 8.04 (s, 1H), 7.80-7.82 (m, 2H), 7.87 (d, J=4.1 Hz, 1H), 7.46-7.50 (m, 2H), 6.86-6.87 (m, 1H), 2.39 (s, 3H). LC/MS (ESI) 451.
Synthetic Example 122
Synthesis of 4-{[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-chlorobenzoic acid
From 2-(4-chlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (25.2 mg, 0.1 mmol) and 4-hydrazinocabonothioylamino-2-chlorobenzoic acid (24.5 mg, 0.1 mmol), the desired product was obtained in the same manner as in Synthetic Example 50 as a pale yellow solid (41.9 mg, yield 88%).
1H-NMR (ppm in DMSO) δ 11.21 (bs, 1H), 10.47 (bs, 1H), 8.15 (s, 1H), 8.05 (s, 1H), 7.87 (d, J=8.3 Hz, 1H), 7.77-7.81 (m, 2H), 7.66 (d, J=8.3 Hz, 1H), 7.46-7.48 (m, 2H), 2.40 (s, 3H ). LC/MS (ESI) 479.
Synthetic Example 123
Synthesis of 4-{[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-nitrobenzoic acid
From 2-(4-chlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (21 mg, 0.083 mmol), the desired product was obtained in the same manner as in Synthetic Examples 92 and 93 as a pale yellow solid (35.2 mg, yield 86%).
1H-NMR (ppm in DMSO) δ 11.32 (bs, 1H), 10.67 (bs, 1H), 8.49 (s, 1H), 8.07 (s, 1H), 7.95-7.98 (m, 1H), 7.89 (d, J=8.4 Hz, 1H), 7.80 (d, J=8.6 Hz, 2H), 7.47 (d, J=8.6 Hz, 2H), 2.41 (s, 3H) LC/MS (ESI) 490.
Synthetic Example 124
Synthesis of 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazine)carbonothioyl]-amino}-benzenesulfonic acid potassium salt
A solution of 2-(3,4-dichlorophenyl)-4-(1-hydorazono-ethyl)thiophen-3-ol (20 mg, 0.066 mmol) and 4-sulfophenyl isothiocyanate sodium salt monohydrate (25 mg, 0.099 mmol) in dimethylformamide (0.2 mL) was stirred at room temperature for 1 hour. To the reaction mixture was added ethanol (2 mL), then the precipitated solid was collected by filtration and dried by means of a vacuum pump to give a pale red solid.
To a solution of the solid in methanol (0.8 mL) was added 0.1M potassium hydroxide methanol solution (0.4 mL), then the reaction mixture was stirred at 40° C. for 10 minutes, evaporated and dried by means of a vacuum pump to give the desired product as a pale red solid. (yield 59.%)
LC/MS: condition 8, retention time 5.32(min) LC/MS (ESI−) m/z; 514, 516 [M−1]−
Synthetic Examples 125-146
Table 17 shows the number of the synthetic examples (S.E.) obtained in the similar manner as described in the synthetic example 124, yields, shapes, LC/MS conditions (L.C.), LC/MS observed peaks (O.P.) and retention times (R.T.).












TABLE 17









yields

O.P.
R.T.













S.E.
(%)
shapes
L.C.
ESI+
ESI−
(min)
















125
65
pale yellow solid
8
515/517
513/515
4.85


126
74
pale yellow solid
3
481/483
479/481
3.38


127
81
white solid
8
480/482
478/480
5.01


128
87
white solid
2
478
476
3.84


129
72
white solid


130
100
pale yellow solid
2
446/448
444/446
4.30


131
87
white solid
2
478/480
476/478
3.87


132
50
pale yellow solid
3
442
440
3.17


133
89
white solid
3
490/492
488/490
3.54


134
94
white solid
3
490/492
488/490
3.54


135
59
white solid
3
496
494
3.55


136
62
white solid
3
440
438
3.47


137
85
pale yellow solid
3
440
438
3.49


138
90
yellow solid
3
475
473
3.40


139
100
white solid
2
513
511
3.74


140
95
white solid
2
513/515
511/513
3.82


141
60
pale yellow solid
3
446/448
444/446
3.45


142
74
pale yellow solid
3
481/483
479/481
3.37


143
81
pale yellow solid
3
525/527
523/525
3.45


144
83
white solid
3
515
513
3.45


145
76
pale yellow solid
8
531
529
4.85


146
83
pale yellow solid
6
503
501
3.60


147

pale yellow solid









Synthetic Example 148
Synthesis of 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazine)carbonothioyl]-amino}-phenol
To a solution of 4-aminophenol (11 mg, 0.099 mmol) in dimethylformamide (0.2 mL) was added N,N′-thiocarbonyl diimidazole (20 mg, 0,112 mmol), and the reaction mixture was stirred at room temperature for 0.5 hour. To the resultant mixture, 2-(3,4-dichlorophenyl)-4-(1-hydorazonoethyl)thiophen-3-ol (20 mg, 0.066 mmol) was added portionwise. The reaction mixture was stirred at 35° C. for 1 hour and quenched with methanol (2 mL) and water (2 mL), and then the precipitated solid was collected by filtration and dried by means of a vacuum pump to give the desired product as a white solid (yield 50%).
LC/MS: condition 8, retention time 5.00 (min) LC/MS (ESI+) m/z; 452, 454 [M+1]+ LC/MS (ESI−) m/z; 450, 452 [M−1]−
Synthetic Examples 149-166
Table 18 shows the number of the synthetic examples (S.E.) obtained in the similar manner as described in the synthetic example 148, yields, shapes, LC/MS conditions (L.C.), LC/MS observed peaks (O.P.) and retention times (R.T.).












TABLE 18









yields

O.P.
R.T.













S.E.
(%)
shapes
L.C.
ESI+
ESI−
(min)
















149
67
white solid
8
466/468
464/466
4.90


150
67
white solid
8
452/454
450/452
4.92


151
85
pale yellow solid
8
479/481
477/479
4.75


152
40
pale yellow solid
8
515/517
513/515
4.85


153
73
white solid
8
528/530
526/528
4.95


154
59
white solid
8
492/494
490/492
4.68


155
34
pale yellow solid
2
474/476
472/474
3.83


156
31
white solid
8
479/481
477/479
4.80


157
26
white solid
3
491
489
3.12


158
62
yellow solid
3
490
488
2.82


159
100
yellow solid
3
527
525
3.19


160
70
pale green solid
3
492
490
2.95


161
38
pink solid
3
491
489
3.13


162
42
yellow solid
2
490/492
488/490
3.45


163
65
pale yellow solid
2
492/494
490/492
3.65


164
92
yellow solid
7
523/525
521/523
2.94


165
14
pale yellow solid


166
40
pale yellow solid
2
598/600
596/598
4.77









Synthetic Example 167
Synthesis of 4-(5-chloro-2-{[(2-{1-[4-hydroxy-1-methyl-5-(4-trifluoromethylphenyl)-1H-pyrazol-3-yl]-ethylidene}-hydrazino)carbonothioyl]amino}-phenoxy)-butyric acid
To a suspension of ethyl 4-(5-chloro-2-{[(2-{1-[4-hydroxy-1-methyl-5-(4-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}-phenoxy)butyrate (74 mg, 0.12 mmol) in ethanol (3.0 mL) was added 1 M aqueous sodium hydroxide (370 μL, 0.37 mmol). After the reaction mixture was stirred at room temperature for 19 hours, 1 M hydrochloric acid (370 μL, 0.37 mmol) was added then the precipitated solid was collected by filtration, washed with chloroform and dried by means of a vacuum pump to give the desired product as a yellow solid (yield 59%).
LC/MS: condition 3, retention time 3.60 (min) LC/MS (ESI+) m/z; 570, 572 [M+1]+ LC/MS (ESI−) m/z; 568, 570 [M−1]−
Synthetic Example 168
Synthesis of 4-(5-chloro-2-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]-ethylidene}hydrazino)carbonothioyl]amino}phenoxy)-butyric acid
This compound was obtained in the similar manner as described in the reference synthetic example 167.
Yield: 50%. Shape: white solid. LC/MS: condition 2, retention time 4.52 (min) LC/MS (ESI+) m/z; 570, 572 [M+1]+ LC/MS (ESI−) m/z; 568, 570 [M−1]−
Synthetic Examples 169-183
Table 19 shows the number of the synthetic examples (S.E.) obtained in the similar manner as described in the synthetic example 31, yields, shapes, LC/MS conditions (L.C.), LC/MS observed peaks (O.P.) and retention times (R.T.).












TABLE 19









yields

O.P.
R.T.













S.E.
(%)
shapes
L.C.
ESI+
ESI−
(min)





169
37
white solid
8
499/501
497/499
5.32


170
79
yellow solid
5
437/439
435/437
5.07


171
87
pale yellow solid


172
91
yellow solid
5
406/408
404/406
4.57


173
33
white solid
8
437/439
435/437
4.78


174
62
white solid
8
406/408
404/406
4.79


175
50
white solid
8
420/422
418/420
4.97


176
51
white solid
5
435/437
433/435
4.29


177
62
white solid
5
420/422
418/420
5.90


178
75
white solid
7
522/524
520/522
3.42


179
89
white solid
5
454/456
452/454
4.47


180
86
pale yellow solid
3
406
404
3.00


181
49
yellow solid
8
495/497
493/495
5.08


182
71
white solid
5
421/423
419/421
4.92


183
67
pale yellow solid


184
80
white solid
3
397
395
3.30









Synthetic Example 185
Synthesis of 4-{1-[4-acetoxy-5-(4-tert-butylphenyl)thiphen-3-yl]ethylidenehydrazinocarbonyl}-2-nitro benzoic acid
1) Synthesis of acetic acid 4-acetyl-2-(4-tert-butylphenyl)thiophen-3-yl ester
To a solution of 2-(4-tert-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (137 mg, 0.5 mmol) in THF (2 mL) is were added triethylamine (105 μL, 0.75 mmol) and acetyl chloride (53.3 μL, 0.75 mmol). The reaction mixture was stirred at room temperature for 0.5 h. After removing solvent, the residue was diluted with AcOEt, washed with a saturated aqueous NH4Cl solution, dried over MgSO4 and concentrated to give product as a brown oil (146 mg, yield 92%).
LC/MS: condition 7, retention time 3.25 (min) LC/MS (ESI+) m/z; 317 [M+1]+
2) Synthesis of 4-{1-[4-Acetoxy-5-(4-tert-butylphenyl)thiphen-3-yl]ethylidenehydrazinocarbonyl}-2-nitro benzoic acid
To a solution of acetic acid 4-acetyl-2-(4-tert-butylphenyl)thiophen-3-yl ester (63.3 mg, 0.2 mmol) and 4-hydrazinocarbonyl-2-nitrobenzoic acid (54.0 mg, 0.24 mmol) in DMF (1 mL) was added 12 M aqueous HCl solution (16.7 μL, 0.2 mmol). The reaction mixture was stirred overnight, and then water was added. The precipitated solid was collected by filtration and washed with water and CHCl3 to give product as a pale yellow solid (29.1 mg, yield 28%).
LC/MS: condition 7, retention time 3.20 (min) LC/MS (ESI+) m/z; 524 [M+1]+ LC/MS (ESI−) m/z; 522 [M−1]−
Synthetic Example 186
Synthesis of 4-{1-[4-acetoxy-5-(3,4-dichlorophenyl)thiphen-3-yl]ethylidenehydrazinocarbonyl}-2-nitrobenzoic acid
1) Synthesis of acetic acid 4-acetyl-2-(3,4-dichlorophenyl)thiophen-3-yl ester
The title compound was prepared from 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (201 mg, 0.7 mmol) following the procedure described in the synthetic example 185.
colorless solid (223 mg, yield 97%).
LC/MS: condition 7, retention time 3.09 (min) LC/MS (ESI+) m/z; 287, 289 [M-Ac]+ LC/MS (ESI−) m/z; 285, 287 [M-Ac]−
2) Synthesis of 4-{1-[4-Acetoxy-5-(3,4-dichlorophenyl)thiphen-3-yl]ethylidenehydrazinocarbonyl}-2-nitrobenzoic acid
The title compound was prepared from acetic acid 4-acetyl-2-(3,4-dichlorophenyl)thiophen-3-yl ester (39.5 mg, 0.12 mmol) and 4-hydrazinocarbonyl-2-nitrobenzoic acid (40.5 mg, 0.18 mmol) following the procedure described in the synthetic example 185.
white solid (17.5 mg, yield 27%). LC/MS: condition 7, retention time 3.07 (min) LC/MS (ESI+) m/z; 536, 538 [M+1]+ LC/MS (ESI−) m/z; 534, 536 [M−1]−
Synthetic Example 187
Synthesis of 4-(2-{1-[4-Acetoxy-5-(3,4-dichlorophenyl)thiphen-3-yl]ethylidene}hydrazinecarbothioamido)-2-chlorobenzoic acid
The title compound was prepared from acetic acid 4-acetyl-2-(3,4-dichlorophenyl)thiophen-3-yl ester (39.5 mg, 0.12 mmol) and 2-chloro-4-(hydrazinecarbothioamido)benzoic acid (40.5 mg, 0.132 mmol) following the procedure described in the synthetic example 185.
pale yellow solid (15.1 mg, yield 23%). LC/MS: condition 7, retention time 3.12 (min) LC/MS (ESI+) m/z; 556, 558 [M+1]+ LC/MS (ESI−) m/z; 554, 556 [M−1]−
Synthetic Examples 188-224
Table 20 shows the number of the synthetic examples (S.E.) obtained in the similar manner as described in the synthetic example 50, yields, shapes, LC/MS conditions (L.C.), LC/MS observed peaks (O.P.) and retention times (R.T.).












TABLE 20









yields

O.P.
R.T.













S.E.
(%)
shapes
L.C.
ESI+
ESI−
(min)
















188
67
pale yellow solid
7
504/506
502/504
3.19


189
72
pale yellow solid
7
524/526
522/524
3.19


190
46
white solid
6
436/438
434/436
3.45


191
44
white solid
6
451/453
449/451
3.77


192
73
pale yellow solid
9
508/510
506/508
3.42


193
67
yellow solid
5
456
454
4.02


194
49
brown solid
5
476/478
474/476
4.17


195
47
pale brown solid
8
510
508
5.03


196
44
brown solid
2
530/532
528/530
4.49


197
31
pale brown solid
2
462
460
4.92


198
29
pale yellow solid
2
403/405
401/403
4.00


199
75
white solid
2
435
433
3.57


200
86
white solid
2
404/406
402/404
3.60


201
60
pale yellow solid
2
394
392
4.40


202
42
white solid


203
88
white solid
2
435/437
433/435
3.62


204
45
pale brown solid
9
444
442
3.82


205
65
pale yellow solid
9
464/466
462/464
2.92


206
53
pale brown solid
9
494/496
492/494
4.14


207
78
pale yellow solid
3
514/516
512/514
3.63


208
70
white solid
2
444
442
4.65


209
97
yellow solid
2
460/462
458/460
4.79


210
74
brown solid
2
480/482
478/480
4.42


211
40
pale yellow solid


212
80
yellow solid
3
454
452
4.25


213
100
yellow solid
3
474/476
472/474
3.60


214
99
pale yellow solid
3
366
364
3.34


215
33
pale yellow solid


216
40
pale yellow solid


217
67
yellow solid
8
430/432
428/430
4.78


218
60
pale yellow solid
8
473/475
471/473
4.92


219
66
pale yellow solid
8
479/481
477/479
5.10


220
84
pale yellow solid
8
489/491
487/489
4.78


221
46
pale yellow solid
8
495/497
493/495
4.82


222
50
white solid
8
465/467
463/465
5.07


223
47
white solid
8
481/483
479/481
4.93


224
57
yellow solid
2
494/496
492/494
4.52









Synthetic Example 225
Synthesis of quinoxaline-6-carboxylic acid {1-[5-(3,4-dichlorophenyl)-4-hydroxy-thiophen-3-yl]-ethylidene}-hydrazide
A solution of 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (25 mg, 0.087 mmol) and quinoxaline-6-carboxylic acid hydrazide (25 mg, 0.087 mmol) in dimethylsulfoxide (0.5 mL) was stirred at 100° C. for 12 hours and the reaction mixture was concentrated under the reduced pressure. To the residue was added chloroform and the precipitated solid was collected by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (yield 10%).
LC/MS: condition 8, retention time 3.77 (min) LC/MS (ESI+) m/z; 457, 459 [M+1]+ LC/MS (ESI−) m/z; 455, 457 [M−1]−
Synthetic Examples 226-233
Table 21 shows the number of the synthetic examples (S.E.) obtained in the similar manner as described in the synthetic example 225, yields, shapes, LC/MS conditions (L.C.), LC/MS observed peaks (O.P.) and retention times (R.T.).












TABLE 21









yields

O.P.
R.T.













S.E.
(%)
shapes
L.C.
ESI+
ESI−
(min)
















226
45
orange solid
5
539/541
537/539
3.70


227
53
orange solid
5
525/527
523/525
3.63


228
84
yellow solid
2
462
460
3.74


229
49
yellow solid
6
480
478
3.54


230
80
white solid
9
464

3.09


231
85
yellow solid
3
430/432
428/430
3.50


232
95
red solid
2
476/478
474/476
4.35


233
71
pale yellow solid
8
424
422
4.78









Synthetic Example 234
Synthesis of 1H-benzoimidazole-5-carboxylic acid {1-[5-(3,4-dichloro-phenyl)-4-hydroxy-thiophen-3-yl]-ethylidene}-hydrazide
To a suspension of 1H-benzoimidazole-5-carboxylic acid (24 mg, 0.15 mmol) in toluene (0.5 mL) was added thionyl chloride (11 μL, 0.15 mmol). The reaction mixture was stirred at 100° C. for 1 hour and concentrated under the reduced pressure. To the residue was added a solution of 2-(3,4-dichlorophenyl)-4-(1-hydorazonoethyl)thiophen-3-ol (30 mg, 0.10 mmol) in dimethylacetamide (0.6 mL) and the reaction mixture was stirred at room temperature for 2 hours. To the reaction mixture was added methanol and water then the precipitated solid was filtrated and dried by means of a vacuum pump to give the desired product as a gray solid (yield 38%).
LC/MS: condition 8, retention time 4.27 (min) LC/MS (ESI+) m/z; 445, 447 [M+1]+ LC/MS (ESI−) m/z; 443, 445 [M−1]−
Synthetic Example 235
Synthesis of N′-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-thiophen-3-yl]ethylidene}-4-methylisoxazole-5-carbohydrazide
This compound was obtained in the similar manner as described in the reference synthetic example 234.
Yield: 46%. Shape: yellow solid. LC/MS: condition 8, retention time 5.02 (min) LC/MS (ESI+) m/z; 410, 412 [M+1]+ LC/MS (ESI−) m/z; 408, 410 [M−1]−
Synthetic Example 236
Synthesis of 2-chloro-N′-{1-[5-(3,4-dichlorophenyl)-4-hydroxythiophen-3-yl]ethylidene}nicotinohydrazide
This compound was obtained in the similar manner as described in the reference synthesis example 234.
Yield: 50%. Shape: pale yellow solid. LC/MS: condition 8, retention time 5.10 (min) LC/MS (ESI+) m/z; 440, 442 [M+1]+ LC/MS (ESI−) m/z; 438, 440 [M−1]−
Synthetic Example 237
Synthesis of 4-hydroxymethyl-3-nitrobenzoic acid {1-[5-(4-tert-butylphenyl)-4-hydroxythiophen-3-yl]ethylidene}-hydrazide
1) Synthesis of 4-hydroxymethyl-3-nitrobenzoic acid
4-Bromomethyl-3-nitrobenzoic acid (3.00 g, 11.5 mmol) and sodium carbonate (6.12 g, 57.7 mmol) were dissolved in water (40 mL) and acetone (40 mL). The reaction mixture was refluxed for 4 hours and then concentrated under reduced pressure to remove acetone. The residue was washed with diethyl ether three times. The aqueous layer was acidified with 6M hydrochloric acid, and then extracted with ethyl acetate three times. The combined organic layer was washed with water and brine, dried with sodium sulfate, filtered, concentrated under the reduced pressure. The residue was dried by means of a vacuum pump to give the desired product as brown solid (2.17 g, yield 95%).
LC/MS: condition 5, retention time 1.59 (min) LC/MS (ESI−) m/z; 196 [M−1]−
2) Synthesis of 4-(tert-butyldimethylsilanyloxymethyl)-3-nitrobenzoic acid
To a solution of 4-hydroxymethyl-3-nitrobenzoic acid (1.50 g, 7.62 mmol) and imidazole (1.55 g, 22.8 mmol) in dimethylformamide (20 mL) was added tert-butyldimethyl-silyl chloride (2.23 g, 14.8 mmol), and then the reaction mixture was stirred at room temperature for 15 hours. To the reaction mixture, saturated ammonium chloride aqueous solution was added and acidified with 1 M hydrochloric acid. The aqueous layer was extracted with ethyl acetate three times. The combined organic layer was washed with saturated ammonium chloride aqueous solution, water and brine, dried with sodium sulfate, filtered, and concentrated under the reduced pressure. The residue was purified by silica gel column chromatography to give the desired product as a white solid (1.73 g, yield 73%).
LC/MS: condition 5, retention time 5.10 (min) LC/MS (ESI−) m/z; 310 [M−1]−
3) Synthesis of 4-(tert-butyldimethylsilanyloxymethyl)-3-nitrobenzoic acid hydrazide
To a solution of 4-(tert-butyl-dimethylsilanyloxy-methyl)-3-nitrobenzoic acid (1.00 g, 3.22 mmol), N,N,N′,N′-tetramethylfluoroformamidinium hexafluoro-phosphate (852 mg, 3.23 mmol) and triethylamine (0.90 mL, 6.44 mmol) in dimethylformamide (13 mL), hydrazine monohydrate (0.31 mL, 6.43 mmol) was added at 0° C., and then the reaction mixture was stirred at 0° C. for 8 hours. To the reaction mixture was added water (10 mL), then the precipitated solid was filtrated and dried by means of a vacuum pump to give the desired product as a pale gray solid (461 mg, yield 44%).
LC/MS: condition 5, retention time 4.14 (min) LC/MS (ESI+) m/z; 326 [M+1]+ LC/MS (ESI−) m/z; 324 [M−1]−
4) Synthesis of 4-hydroxymethyl-3-nitrobenzoic acid {1-[5-(4-tert-butylphenyl)-4-hydroxythiophen-3-yl]-ethylidene}hydrazide
A solution of 2-(4-tert-butylphenyl)-3-hydroxy-4-methyl-carbonylthiophene (27.8 mg, 0.10 mmol), 4-(tert-butyl-dimethylsilanyloxymethyl)-3-nitrobenzoic acid hydrazide (34.9 mg, 0.11 mmol) and p-toluenesulfonic acid monohydrate (5.7 mg, 0.03 mmol) in isopropanol (1.0 mL) was stirred at 95° C. for 7 hours. The precipitated solid was collected by filtration and dried by means of a vacuum pump to give the desired product as yellow solid (34.8 mg, yield 73%).
LC/MS: condition 5, retention time 5.53 (min) LC/MS (ESI+) m/z; 468 [M+1]+ LC/MS (ESI−) m/z; 466 [M−1]−
Synthetic Example 238
Synthesis of N′-[1-{5-(3,4-dichlorophenyl)-4-hydroxy-thiophen-3-yl}ethylidene]-2-oxo-2,3-dihydro-1H-benzo-[d]imidazole-5-carbohydrazide
To a suspension of 3,4-diamino-N′-[1-{5-(3,4-dichlorophenyl)-4-hydroxythiophen-3-yl}ethylidene]-benzohydrazide (30 mg, 0.064 mmol, see the synthetic example 176) in tetrahydrofuran (3.0 mL) was added sodium tert-butoxide (12 mg, 0.13 mmol) and N,N′-carbonyl diimidazole (15 mg, 0.095 mmol). The reaction mixture turned clear orange and was stirred at room temperature for 16 hours, and then N,N′-carbonyl diimidazole (15 mg, 0.095 mmol) was added. The reaction mixture was stirred further for 12 hours, acidified with 1M aqueous HCl solution (0.7 mL) and concentrated under the reduced pressure. To the residue was added water (4 mL), then the precipitated solid was collected by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (yield 97%).
1H-NMR (DMSO-d6) δ (ppm): 2.46 (s, 3H), 7.05 (d, J=8.0 Hz, 1H), 7.51 (s, 1H), 7.57-7.73 (m, 3H), 8.06 (s, 1H), 8.07 (s, 1H), 10.93 (s, 1H), 11.01 (s, 1H), 11.23 (s, 1H), 12.92 (br s, 1H)
Synthetic Example 239
Synthesis of N′-[1-{5-(4-tert-butylphenyl)-4-hydroxythiophen-3-yl}ethylidene]-4-(4-methylpiperazine-1-carbonyl)-3-nitrobenzohydrazide
To a N-methyl-2-pyrrolidinone (1.0 mL) solution of 2-nitro-4-[(2-{1-[S-(4-t-butylphenyl)-4-hydroxy-3-thienyl]-ethylidene}hydrazino)carbonyl]benzoic acid (50 mg, 0.10 mmol, see the synthetic example 47) and triethylamine (16 μL, 0.11 mmol) was added isobutyl chloroformate (26 μL, 0.20 mmol) at 0° C. The reaction mixture was stirred for 2 hours at this temperature, and then N-methyl piperazine (45 μL, 0.40 mmol) was added. After stirring for 1 hour at room temperature, the reaction mixture was acidified with 1M aqueous HCl solution (1.0 mL) and concentrated under the reduced pressure. To the residue was added water, then the precipitate was collected by filtration, washed with water, isopropanol and methanol, then dried by means of a vacuum pump to give the desired product as a pale yellow solid (yield 10%).
LC/MS: condition 6, retention time 2.57 (min) LC/MS (ESI+) m/z; 564 [M+1]+ LC/MS (ESI−) m/z; 562 [M−1]−
Synthetic Example 240
Synthesis of N′-[1-{5-(3,4-dichlorophenyl)-4-hydroxythiophen-3-yl}ethylidene]-2-thioxo-2,3-dihydro-1H-benzo[d]imidazole-5-carbohydrazide
To a suspension of 3,4-diamino-N′-[1-{5-(3,4-dichlorophenyl)-4-hydroxythiophen-3-yl}ethylidene]benzohydrazide (30 mg, 0.064 mmol, see the synthetic example 176) in tetrahydrofuran (3.0 mL) was added sodium tert-butoxide (12 mg, 0.13 mmol) and N,N′-thiocarbonyldiimidazole (23 mg, 0.13 mmol). The reaction mixture turned clear orange and was stirred at room temperature for 16 hours, and then was acidified with 1M aqueous HCl solution (1.0 mL) and concentrated under the reduced pressure. The precipitated solid was collected by filtration, washed with chloroform, washed with methanol and dried by means of a vacuum pump to give the desired product as a pale brown solid (yield 52%).
1H-NMR (DMSO-d6) δ (ppm): 2.5 (s, 3H, overlapped by DMSO-d6), 7.26 (d, J=8.3 Hz, 1H), 7.64 (d, J=8.5 Hz, 1H), 7.69 (dd, J=8.5&1.7 Hz, 1H), 7.71 (s, 1H), 7.77 (d, J=8.3 Hz, 1H), 8.06 (d, J=1.7 Hz, 1H), 8.09 (s, 1H), 11.37 (s, 1H), 14.85 (br s, 1H), 14.87 (br s, 1H).
The structural formulae of the compounds obtained in the Synthetic Examples are given below.












SYNTHETIC EX. 1








 


SYNTHETIC EX. 2








 


SYNTHETIC EX. 3








 


SYNTHETIC EX. 4








 


SYNTHETIC EX. 5








 


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Assay Example 1
Stimulation of Proliferation of a Thrombopoietin (TPO)-dependent Cell Line (1)
The reactivity of the compound of Synthetic Example 3 of the present invention with thrombopoietin (TPO) receptor was assayed using a human leukemic cell line, UT7/EPO-mpl.
(1) Cells and Cell Culture
UT7/EPO-mpl is a stable transformed cell line obtained by introducing into human leukemic cell line UT7/EPO a vector that induces expression of human TPO receptor (c-mp1) under control of a cytomegaloviral promoter by the method of Takatoku et al. (J. Biol. Chem., 272:7259-7263 (1997)). Proliferation of this cell line is stimulated by TPO, while its mother cell line UT7/EPO exhibits no response to TPO. These two cell lines were subcultured in Iscove's modified Dulbecco's medium (IMDM; GIBCO) containing 10% fetal bovine serum (FBS; TRACE SCIENTIFIC, Thermo Electron or BioWest) using a CO2 incubator (5% CO2, 37° C.)
(2) Cell Proliferation Assay
The subcultured cells described above were washed twice with phosphate buffered saline (PBS) and suspended in IMDM containing 10% FBS at a cell density of 6×104 cells/ml. The cell suspension was transferred to a 96-well tissue culture plate (CORNING) in 100-μl aliquots. Then either TPO (PeproTech EC) or the compound of Synthetic Example 3 dissolved in dimethyl sulfoxide (DMSO) was diluted 83-fold with IMDM containing 10% FBS and added to the aforementioned cell suspension in 20-μl aliquots. The suspension was incubated in a CO2 incubator (5%. CO2, 37° C.) for 4 days. Cell proliferation was assayed using WST-8 reagent (Kishida Chemical Co., Ltd.) according to instructions by the manufacturer. A 10-μl aliquot of 5 mM WST-8 reagent solution was added to each well of the tissue culture plate, and the plate was incubated at 37° C. for 4 h. The formazan pigment generated was detected by measuring the absorbance at 450 nm with a 96-well microplate reader (Nihon Molecular Devices, Spectramax 190). FIG. 1 shows the results with UT7/EPO-mpl cells, while FIG. 2 shows data obtained with UT7/EPO cells expressing no TPO receptor.
Assay Example 2
Activity of Signal Transduction Mediated by TPO Receptor
The signal-transducing activity of the compound of Synthetic Example 3 of the present invention mediated by TPO receptor was assayed according to the method of Komatsu et al. (Blood, 87:4552-4560 (1996)). Human leukemic cell line UT7/EPO-mpl was washed three times with PBS and suspended in IMDM containing 10% FBS at a cell density of 9×105 cells/ml. The cell suspension was incubated in a CO2 incubator (5% CO2, 37° C.) for 18 h. To 2 ml of this cell suspension (7×106 cells/ml), either TPO (final concentration, 30 ng/ml) or a DMSO solution of the compound of Synthetic Example 3 (final concentration, 1 μg/ml) was added. After incubating the mixture at 37° C. for 1-15 min, the cells were lysed in 1.4 ml of TNE buffer (20 mM Tris-HCl buffer (pH 7.4) containing 150 mM NaCl, 1 mM EDTA, 1% Triton X-100, 1 mM PMSF, 1 mM Na3VO4, and 1/400-diluted Protease Inhibitor Cocktail (SIGMA)). The cell lysate was centrifuged to collect the supernatant for immunoprecipitation with antibodies against proteins involved in signal transduction (anti-STAT3 (SANTA CRUZ BIOTECHNOLOGY) and anti-STAT5A (UPSTATE BIOTECHNOLOGY)) and protein G Sepharose (PHARMACIA). The immunoprecipitated protein fraction was collected and denatured in a sample buffer for separation by SDS-polyacrylamide gel electrophoresis (7.5%). The separated proteins were transferred onto polyvinylidene difluoride (PVDF) membrane (Atto Corporation, 0.2 μm pore size) at 100 V for 1 h for detection of tyrosine phosphorylation using an alkaline phosphatase-labelled antibody against phosphorylated tyrosine (RC20, TRANSDUCTION LABORATORIES). The antigen-antibody complex formed on the PVDF membrane was visualized with 150 μg/ml NBT (BIO-RAD) and 300 μg/ml BCIP (BIO-RAD). The results are summarized in Table 22.











TABLE 22








SYNTHETIC




DMSO
EXAMPLE 3
TPO





















STAT 3
−
+
+



STAT 5A
−
+
+










FIG. 1 demonstrated that proliferation of TPO-responsive UT7/EPO-mpl cells was stimulated by the compound of Synthetic Example 3 in a concentration-dependent manner, while no effect of this compound on proliferation was observed with UT7/EPO, the mother cell line, as shown in FIG. 2. These results indicate that the compound of Synthetic Example 3 of the present invention acts on the TPO receptor selectively as an activator.
Table 22 shows that the compound of Synthetic Example 3 stimulates phosphorylation of STAT3 and STAT5A in the same manner as TPO does. The results demonstrate that the compound of the present invention shows agonistic action through the same signal transduction as that caused by TPO.
Assay Example 3
The compounds of the following Synthetic Examples were tested according to the method of Assay Example 1 to determine the concentration of each compound that yields a growth rate corresponding to 50% of the growth of human leukemic cell line UT-7/EPO-mpl observed in the presence of 10 ng/ml TPO (EC50). The results are summarized in Table 23.










TABLE 23







Synthetic Example No.
EC50 (ng/ml)



















1
3.5



2
4.5



3
2.7



4
10.5



5
45.0



6
3.5



7
3.8



8
3.7



9
5.9



10
21.3



11
2.9



13
7.8



32
4.3



49
14



76
5.8



89
3.2



97
4.7



107
3.3



113
4.7



124
2.9



126
3.4



127
3.5



136
3.1



154
2.8



155
5.3



157
3.1



161
3.9



164
3.0



167
3.9



169
3.7



176
16



178
3.4



179
3.0



181
2.8



212
0.24



218
2.2



221
2.9



226
2.2



228
0.72



235
13



239
4.2



240
6.0










Assay Example 4
Megakaryocyte Colony Stimulating Activity
The action of the compound of Synthetic Example 2 of the present invention on the proliferation, differentiation and maturation of megakaryocyte cells was measured by the megakaryocyte colony forming method using human bone marrow cells. Human bone marrow CD34+ cells (Cambrex Bio Science Walkersville) were incubated on 2-well chamber slide for 11 days in a CO2 incubator (5% CO2, 37° C.) using MegaCultTM-C (StemCell Technologies) containing 0.1% (v/v) of the compound of Synthetic Example 2 dissolved in DMSO. After dehydration and fixation, the cells were stained with an anti-glycoprotein IIb/IIIa antibody in accordance with the instruction by the manufacturer. The colonies consisting of at least 8 stained megakaryocyte cells in each well was counted under a microscope. The megakaryocyte colony counts of duplicate or more assays were averaged.
The results demonstrate that the compound of the present invention has excellent megakaryocyte colony stimulating activity and increases platelets through the activity.
The results are shown in Table 24.












TABLE 24









Synthetic
Concentration (μg/ml)
0.3
1



Example 2




Megakaryocyte colony
25
48




Count










Formulation Example 1
A granule preparation containing the following ingredients is prepared.













Ingredients




















Compound represented by the formula (1)
10
mg



Lactose
700
mg



Corn Starch
274
mg



HPC-L
16
mg




1000
mg










A compound represented by the formula (1) and lactose are sifted through a 60-mesh sieve. Corn starch is sifted though a 120-mesh sieve. They are mixed in a V-type blender. The powder mixture is kneaded with a low-viscosity hydroxypropylcellulose (HPC-L) aqueous solution, granulated (extrusion granulation, die size 0.5-1 mm) and dried. The resulting dry granules are sifted through a shaking sieve (12/60 mesh) to obtain a granule preparation.
Formulation Example 2
A powder preparation for capsulation containing the following ingredients is prepared.
Ingredients













Ingredients



















Compound represented by the formula (1)
10 mg



Lactose
79 mg



Corn Starch
10 mg



Magnesium Stearate
 1 mg




100 mg 










A compound represented by the formula (1) and lactose are sifted through a 60-mesh sieve. Corn starch is sifted though a 120-mesh sieve. They are mixed with magnesium stearate in a V-type blender. The 10% powder is put in hard capsules No. 5, 100 mg each.
Formulation Example 3
A granule preparation for capsulation containing the following ingredients is prepared.
Ingredients













Ingredients



















Compound represented by the formula (1)
15 mg



Lactose
90 mg



Corn Starch
42 mg



HPC-L
 3 mg




150 mg 










A compound represented by the formula (1) and lactose are sifted through a 60-mesh sieve. Corn starch is sifted though a 120-mesh sieve. They are mixed in a V-type blender. The powder mixture is kneaded with a low-viscosity hydroxypropylcellulose (HPC-L) aqueous solution, granulated and dried. The resulting dry granules are sifted through a shaking sieve (12/60 mesh). The granules are put in hard capsules No. 4, 150 mg each.
Formulation Example 4
A tablet preparation containing the following ingredients is prepared.
Ingredients













Ingredients



















Compound represented by the formula (1)
10 mg



Lactose
90 mg



Microcrystalline cellulose
30 mg



Magnesium Stearate
 5 mg



CMC-Na
15 mg




150 mg 










A compound represented by the formula (1), lactose, microcrystalline cellulose and CMC-Na (carboxymethylcellulose sodium salt) are sifted through a 60-mesh sieve and mixed. The powder mixture is mixed with magnesium stearate to give a bulk powder mixture. The powder mixture is compressed directly into 150 mg tablets.
Formulation Example 5
An intravenous preparation is prepared as follows.

















Compound represented by the formula (1)
100
mg



Saturated Fatty Acid Glyceride
1000
ml










Solutions having the above-mentioned composition are usually administered to a patient intravenously at a rate of 1 ml per 1 minute.
INDUSTRIAL APPLICABILITY
The compounds of the present invention which have affinity for thrombopoietin receptor and act as thrombopoietin receptor agonists are useful as preventive, therapeutic and improving agents for diseases against which activation of the thrombopoietin receptor is effective, especially as drugs for hematological disorders accompanied by abnormal platelet count and as drugs for diseases treated or prevented by stimulating differentiation and proliferation of vascular endothelial cells and endothelial progenitor cells, and are useful as medicines.

## Claims

1. A compound represented by the formula (1)




wherein A is CR4 (wherein R4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C2-6 alkenyl group or a C2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a C1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2-6 alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group, a mono- or di-C1-10 alkylamino group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group, the mono- or di-C1-10 alkylamino group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), or R6 and R7 mean, together with each other, —(CH2)m1-E-(CH2)m2— (wherein E is an oxygen atom, a sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom, a C1-10 alkyl group, a C2-14 aryl group, a C1-10 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR8 (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C2-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), and each of m1 and m2 is independently an integer of from 0 to 5 provided that m1m2 is 3, 4 or 5)))),
B is a sulfur atom,
R1 is a C2-14 aryl group (the C2-14 aryl group may be substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group, OCHO, a cyano group, a hydroxyl group, a protected hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyl group, the C1-10 alkylcarbonyloxy group and the C1-10 alkoxycarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a c2-14 aryl group and a C2-14 aryloxy group), a thiol group and an amino group (the thiol group and the amino group may be optionally substituted with one or two substituents selected from the group consisting of: a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group and a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)))),
L1 is a bond, CR10R11 (where in each of R10 and R11 is independently a hydrogen atom or a C1-6 alkyl group (the C1-6 alkyl group may be substituted with one or more halogen atoms)), an oxygen atom, a sulfur atom or NR12 (wherein R12 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)),
X is OR13, SR13 or NR14R15 (wherein R13 is a hydrogen atom, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), and each of R14 and R15 is independently a hydrogen atom, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)),
R2 is a hydrogen atom, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyloxy group, (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkoxycarbonyl group, the C1-10 alkylcarbonyloxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)
L2 is a bond, CR34R35 (wherein each of R34 and R35 is independently a hydrogen atom or a C1-6 alkyl group (the C1-6alkyl group may be substituted with one or more halogen atoms)), an oxygen atom, a sulfur atom or NR16 (wherein R16 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group))
L3 is a bond, CR17R18 (wherein each of R17 and R18 is independently a hydrogen atom, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), an oxygen atom, a sulfur atom or NR19 (wherein R19 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group))
L4 is a bond, CR20R21 (wherein each of R20 and R21 is independently a hydrogen atom, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), an oxygen atom, a sulfur atom or NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)),
Y is an oxygen atom, a sulfur atom or NR23 (wherein R23 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), and
R3 is a C2-14 aryl group (the C2-14 aryl group may be substituted with one or more substituents independently represented by —W1(CW2W3)mW4 (wherein W1 is (CR24R25)n (wherein each of R24 and R25 is independently a hydrogen atom or a C1-6 alkyl group, (the C1-6 alkyl group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR36 (wherein R36 is a hydrogen atom, a C1-6 alkyl group, a formyl group or a C1-6 alkylcarbonyl group), each of W2 and W3 is independently a hydrogen atom or a C1-3 alkyl group (the C1-3 alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3, and W4 is a hydroxyl group, a thiol group, an amino group, a formyl group, a halogen atom, a nitro group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group, a mono- or di-C1-10 alkylamino group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group and the mono- or di-C1-10 alkylamino group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, a amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a thiol group, a phosphonic acid group, a sulfonic acid group, a tetrazole group, a C2-14 aryl group and a C2-14 aryloxy group), SO2R28, SOR28, COR28 (wherein R28 is a hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group, a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or NR29R30 (wherein each of R29 and R30 is independently a hydrogen atom, a hydroxyl group, a formyl group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), or R29 and R30, together with each other means —(CH2)m3-G-(CH2)m4— (wherein G is an oxygen atom, a sulfur atom, a CR31R32 (where in each of R31 and R32 is independently a hydrogen atom, a C1-10 alkyl group, a C2-14 aryl group, a C1-10 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR33 (wherein R33 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-0 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-0 alkylcarbonyloxy group, the C1-10alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), and each of m3 and m4 is independently an integer of from 0 to 5, provided that m3+m4 is 3, 4 or 5))), a tetrazole group, or a phosphonic acid group)), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

2. The compound according to claim 1, wherein L1 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

3. The compound according to claim 1, wherein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

4. The compound according to claim 2, wherein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

5. The compound according to claim 1, wherein L3 is NR19 (wherein R19 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

6. The compound according to claim 1, wherein L3 is NH, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

7. The compound according to claim 5, wherein L4is NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C2-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

8. The compound according to claim 6, wherein L4 is NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

9. The compound according to claim 5, wherein L4is NH, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

10. The compound according to claim 6, wherein L4 is NH, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

11. The compound according to claim 5, wherein L4is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

12. The compound according to claim 6, wherein L4 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

13. The compound according to claim 7, wherein Y is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

14. The compound according to claim 8, wherein Y is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

15. The compound according to claim 9, wherein Y is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

16. The compound according to claim 10, wherein Y is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

17. The compound according to claim 11, wherein Y is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

18. The compound according to claim 12, wherein Y is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

19. The compound according to claim 7, wherein Y is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

20. The compound according to claim 8, wherein Y is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

21. The compound according to claim 9, wherein Y is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

22. The compound according to claim 10, wherein Y is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

23. The compound according to claim 11, wherein Y is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

24. The compound according to claim 12, wherein Y is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

25. The compound according to claim 13, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

26. The compound according to claim 14, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

27. The compound according to claim 15, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

28. The compound according to claim 16, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

29. The compound according to claim 17, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

30. The compound according to claim 18, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

31. The compound according to claim 19, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

32. The compound according to claim 20, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

33. The compound according to claim 21, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

34. The compound according to claim 22, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

35. The compound according to claim 23, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

36. The compound according to claim 24, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

37. The compound according to claim 13, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

38. The compound according to claim 14, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

39. The compound according to claim 15, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

40. The compound according to claim 16, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

41. The compound according to claim 17, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

42. The compound according to claim 18, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

43. The compound according to claim 25, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

44. The compound according to claim 26, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

45. The compound according to claim 27, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

46. The compound according to claim 28, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

47. The compound according to claim 29, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

48. The compound according to claim 30, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

49. The compound according to claim 19, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

50. The compound according to claim 20, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

51. The compound according to claim 21, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

52. The compound according to claim 22, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

53. The compound according to claim 23, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

54. The compound according to claim 24, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

55. The compound according to claim 31, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

56. The compound according to claim 32, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

57. The compound according to claim 33, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

58. The compound according to claim 34, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

59. The compound according to claim 35, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

60. The compound according to claim 36, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

61. The compound according to claim 13, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

62. The compound according to claim 14, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

63. The compound according to claim 15, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

64. The compound according to claim 16, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

65. The compound according to claim 17, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

66. The compound according to claim 18, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

67. The compound according to claim 25, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

68. The compound according to claim 26, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

69. The compound according to claim 27, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

70. The compound according to claim 28, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

71. The compound according to claim 29, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group),a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

72. The compound according to claim 30, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

73. The compound according to claim 19, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

74. The compound according to claim 20, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

75. The compound according to claim 21, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

76. The compound according to claim 22, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

77. The compound according to claim 23, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

78. The compound according to claim 24, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

79. The compound according to claim 31, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

80. The compound according to claim 32, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

81. The compound according to claim 33, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group),a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

82. The compound according to claim 34, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

83. The compound according to claim 35, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

84. The compound according to claim 36, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

85. The compound according to claim 13, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:
a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
and one or more substituents selected from the group consisting of:
a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

86. The compound according to claim 14, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:
a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
and one or more substituents selected from the group consisting of:

a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

87. The compound according to claim 15, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:
a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
and one or more substituents selected from the group consisting of:

a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

88. The compound according to claim 16, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:
a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
and one or more substituents selected from the group consisting of:

a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

89. The compound according to claim 17, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:
a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
and one or more substituents selected from the group consisting of:

a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

90. The compound according to claim 18, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:
a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
and one or more substituents selected from the group consisting of:

a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

91. The compound according to claim 25, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:
a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
and one or more substituents selected from the group consisting of:

a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

92. The compound according to claim 26, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:
a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
and one or more substituents selected from the group consisting of:

a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

93. The compound according to claim 27, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:
a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
and one or more substituents selected from the group consisting of:

a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

94. The compound according to claim 28, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:
a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
and one or more substituents selected from the group consisting of:

a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

95. The compound according to claim 29, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:
a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
and one or more substituents selected from the group consisting of:

a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

96. The compound according to claim 30, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:
a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
and one or more substituents selected from the group consisting of:

a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

97. The compound according to claim 19, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:
a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
and one or more substituents selected from the group consisting of:
a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

98. The compound according to claim 20, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:
a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
and one or more substituents selected from the group consisting of:

a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

99. The compound according to claim 21, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:
a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
and one or more substituents selected from the group consisting of:

a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

100. The compound according to claim 22, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:
a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
and one or more substituents selected from the group consisting of:

a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

101. The compound according to claim 23, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:
a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
and one or more substituents selected from the group consisting of:

a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

102. The compound according to claim 24, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:
a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
and one or more substituents selected from the group consisting of:

a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

103. The compound according to claim 31, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:
a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
and one or more substituents selected from the group consisting of:

a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

104. The compound according to claim 32, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:
a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
and one or more substituents selected from the group consisting of:

a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

105. The compound according to claim 33, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:
a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
and one or more substituents selected from the group consisting of:

a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

106. The compound according to claim 34, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:
a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
and one or more substituents selected from the group consisting of:

a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

107. The compound according to claim 35, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:
a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
and one or more substituents selected from the group consisting of:

a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

108. The compound according to claim 36, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:
a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
and one or more substituents selected from the group consisting of:

a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

109. A composition comprising at least one compound of claim 1, a tautomer thereof, a prodrug thereof, a pharmaceutically acceptable salt thereof, and/or a solvate thereof; and at least one carrier.

110. A method of treating thrombocytopenia in a patient in need thereof, comprising administering to the patient an effective amount of at least one compound of claim 1, a tautomer thereof, a prodrug thereof, a pharmaceutically acceptable salt thereof, and/or a solvate thereof to treat the thrombocytopenia.

111. A method of increasing platelets, vascular endothelial cells, and/or endothelial progenitor cells, comprising administering to a patient an effective amount of at least one compound of claim 1, a tautomer thereof, a prodrug thereof, a pharmaceutically acceptable salt thereof, and/or a solvate thereof to increase platelets, vascular endothelial cells, and/or endothelial progenitor cells in the patient.