Exhibit 10.27

SECOND AMENDMENT TO THE

BLOOD DONOR CENTER MANAGEMENT

COMMUNITY MOBILE BLOOD COLLECTIONS

SERVICES AGREEMENT

This SECOND AMENDMENT
is entered into by and between USC University Hospital, Inc., doing business as USC University Hospital (“Hospital”),
a medical center located at 1500 San Pablo Street, Los Angeles, California 90033 and HemaCare Corporation (“HemaCare”),
located at 15350 Sherman Way, Suite 350, Van Nuys, California 91406.

RECITALS

A.Hospital and HemaCare are parties to that certain Services Contract (the “Agreement”)
effective May 1, 2004.

B.Hospital and HemaCare desire to amend the terms of the Agreement as set forth herein below.

NOW, THEREFORE,
the parties hereto, based upon the above recitals and the covenants and conditions set forth herein, agree as follows:

1.TERM AND TERMINATION. Section VI, paragraph A of the Agreement shall be amended as
follows:

This
agreement shall commence May 1, 2007 and continue for a term of two (2) years.

2.HEMACARE'S COMPENSATION. For Services rendered pursuant to this Agreement, Hospital
shall pay HemaCare in accordance with the attached revised Fee Schedule, Attachment “I.” HemaCare will provide Hospital
with thirty (30) days written notice of any fee changes. Fees for the second year of the Agreement will be negotiated at the end
of year one.

3.GENERAL. If provisions of this Amendment and the Agreement conflict, the provisions
of this Amendment shall prevail. Except as specifically amended herein, all terms and conditions of the Agreement shall remain
in full force and effect.

THE PARTIES HERETO
have executed this Amendment on the 10th day of April, 2007.

|USC UNIVERSITY HOSPITAL |          | HEMACARE CORPORATION
|----------------------- | -------- | --------------------
|                        |          |                     
|/s/                     | S. Walsh |                     
|By:                     | S. Walsh |                     
|Title:                  | COO      |                     













Attachment I

USC/NORRIS COMPREHENSIVE CANCER CENTER
BLOOD SERVICES FEE SCHEDULE

Hospital Services Direct Order Lines

800-826-7962 or 818-986-3977

|COMPONENT
    Fees Per Unit                                          |      
|-------------------------------------------------------------------- | -----
|Directed Donor Red Blood Cells                                       | $[l]1
|Directed Donor Leukocyte Reduced Red Blood Cells                     | $[l] 
|Directed Donor Leukocyte Reduced Red Blood Cells, Irradiated         | $[l] 
|Directed Donor Single Donor Platelets, Leukocyte Reduced             | $[l] 
|Directed Donor Single Donor Platelets, Leukocyte Reduced, Irradiated | $[l] 
|Autologous Donor Red Blood Cells                                     | $[l] 
|Autologous Donor Red Leukocyte Reduced Red Blood Cells               | $[l] 
|Leukocyte Reduced Single Donor Platelets                             | $[l] 
|Leukocyte Reduced Single Donor Platelets, Pediatric Unit             | $[l] 
|Allogeneic Red Blood Cells*                                          | $[l] 
|Allogeneic Red Blood Cells, Irradiated                               | $[l] 
|Allogeneic Red Blood Cells, Irradiated, CMV-                         | $[l] 
|Allogeneic Leukocyte Reduced Red Blood Cells                         | $[l] 
|Allogeneic Leukocyte Reduced Red Blood Cells, Irradiated             | $[l] 
|Allogeneic Leukocyte Reduced Red Blood Cells, Irradiated, CMV-       | $[l] 
|Fresh Frozen Plasma                                                  | $[l] 
|Cryoprecipitate                                                      | $[l] 










1
Terms represented by this symbol are considered confidential. These confidential terms have been omitted pursuant
to a Confidential Treatment Request filed with the Securities and Exchange Commission (“SEC”) and have been filed separately
with the SEC.















|Cryo-Poor Plasma                                | $[l]2
|----------------------------------------------- | -----
|Therapeutic Phlebotomy                          | $[l] 
|ADDITIONAL SERVICES                             |      
|CMV Negative Screening Per Unit                 | $[l] 
|Irradiation Fee Per Unit                        | $[l] 
|STAT Distribution Fee Per Order                 | [l]  
|Courier Services in Addition to Normal Delivery | $[l] 

(No charge for transfers between USC/Norris Hospitals during
normal business hours)

Subject to terms and conditions in Blood Donor Center
Management Community Mobile Blood Collections Services Agreement. Pricing in effect thru 04-30-08.

Effective 05-01-07








2
Terms represented by this symbol are considered confidential. These confidential terms have been omitted pursuant to a Confidential
Treatment Request filed with the SEC and have been filed separately with the SEC.