EX-10.15






 Exhibit 10.15 

AMENDMENT TO LICENSE AGREEMENT 

This amendment, dated 22 March 2011, is by and between Cytopherx, Inc. (“LICENSEE”) and the Regents of the University of
Michigan (“MICHIGAN”). 
 WHEREAS, Nephrion, Inc., now doing business as Cytopherx, Inc. and MICHIGAN entered into a license
agreement dated 16 October 2007(the “License Agreement”); and 
 WHEREAS, MICHIGAN and LICENSEE desire to modify certain
provisions of the License Agreement as provided herein. 
 NOW THEREFORE, MICHIGAN and LICENSEE hereby agree as follows: 

1. Existing Paragraph 1.6 shall be deleted in its entirety and replaced with the following: 

1.6 “PATENT RIGHTS” means MICHIGAN’s legal rights under the patent laws of the United States or relevant foreign countries for
all of the following: 
 (a) the following United States and foreign patent application(s), 

 

			
	 COUNTRY/REGION
	  	 APPLICATION NO.

	United States	  	60/969,394
	United States	  	12/201,576
	United States	  	12/827,594
	United States	  	12/827,601
	United States	  	12/827,606
	United States	  	12/827,609
	Patent Cooperation Treaty	  	PCT/US08/74804
	Australia	  	2008293431
	Brazil	  	PI0816165-8
	Canada	  	2,697,681
	China	  	200880113549.4
	Europe	  	08828222.3
	Hong Kong	  	10109152.3
	India	  	1411/DELNP/2010
	Israel	  	204175
	Japan	  	2010-523158
	Korea	  	10-2010-7006729
	Mexico	  	MX/a/2010/002351
	New Zealand	  	583591















 ; any and all United States and foreign patents issuing from said patent applications; any and all
divisionals and continuations claiming priority to one or more of said patent applications; and continuations-in-part of said patent applications, but only continuations-in-part that claim priority to one or more of said patent applications and to the extent that claims are directed to subject matter specifically described in
said patent applications: 
 (b) claims in all patent applications and of the resulting patents, which are directed to subject matter
specifically described as of the Effective Date in the MICHIGAN Office of Technology Transfer file 3718; and 
 (c) any reissued and
reexamined patents, and extensions (including supplementary protection certificates or equivalents thereof), of the patents described in (a) and (b) above. 

2. The Parties agree that LICENSEE has met milestones #1 and #2 in Paragraph 5.2 and wish to amend the remaining milestone as follows: 

3) File PMA Application by Q4, 2014 

3. MICHIGAN’S address in Article 13 shall be revised as follows: 

to MICHIGAN: 
 The University of
Michigan 
 Office of Technology Transfer 

1600 Huron Parkway, 2nd Floor 

Ann Arbor, MI 48109-2590 
 Attn:
UM File #3718 
 4. Except as specifically modified and amended above, all other terms and conditions of the License Agreement remain
unchanged and in effect and are hereby ratified and adopted as though fully set forth herein. 
 IN WITNESS WHEREOF, the parties have
entered into this Amendment to the Amended Agreement as of the date and year first above-written. 
  

									
	CYTOPHERX, INC. 	 		  	 THE REGENTS OF THE UNIVERSITY OF MICHIGAN 

					
	By:	 	 /s/ Mark R. Morsfield
	 		  	By:	  	 /s/ Kenneth J. Nisbet

	Title:	 	Chief Financial Officer	 		  	Title:	  	Executive Director, UM Technology


  
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