exv10w48



 





Exhibit 10.48




CIPHERGEN BIOSYSTEMS, INC.




STOCK PURCHASE AGREEMENT



This STOCK PURCHASE AGREEMENT (this “Agreement”), is made and entered into as of November
13, 2006, by and among CIPHERGEN BIOSYSTEMS, INC., a Delaware corporation (the
“Company”), and BIO-RAD LABORATORIES, INC., a Delaware corporation (the
“Purchaser”) (each a “Party” and together the “Parties”).




     1. Authorization of Sale of the Shares.



          1.1 Shares of Common Stock. Subject to the terms and conditions of this Agreement,
the Company has authorized the sale to the Purchaser of that number of shares of Company’s common
stock based on the price calculated in accordance with Section 2.2 below of common stock (the
“Common Stock”) of the Company for an aggregate purchase price of $3,000,000.00 (the
“Shares”).




     2. Agreement to Sell and Purchase the Shares.



          2.1 Purchase and Sale. Subject to the terms and conditions of this Agreement, the
Purchaser agrees to purchase, and the Company agrees to sell and issue to the Purchaser, at the
Closing, the Shares.




          2.2 Purchase Price. The per share purchase price of the Shares to be sold hereunder
shall be equal to the average closing price of the Company’s Common Stock on the five (5) trading
days immediately preceding August 14, 2006.




     3. Delivery of the Shares at Closing.



          3.1 Closing. The completion of the purchase and sale of the Shares (the
“Closing”) shall occur at the offices of Wilson Sonsini Goodrich & Rosati, PC, counsel to
the Company, at 650 Page Mill Road, Palo Alto, California 94304 at 9:00 a.m. local time on the
“Closing Date” as such date is defined in the Asset Purchase Agreement by and between Purchaser and
Company dated as of August 14, 2006, or such other time and date as may be agreed by the parties
(the “Closing Date”).




          3.2 Issuance and Delivery. At the Closing, the Company shall authorize its transfer
agent to issue to the Purchaser one or more stock certificates registered in the name of the
Purchaser, or in such nominee name(s) as designated by the Purchaser in writing, representing the
number of Shares set forth in Section 1.1 above. The stock certificate representing the Shares,
(the “Certificate”), shall each bear the following legend referring to the fact that the
Shares were sold in



 









 







reliance upon the exemption from registration provided by Section 4(2) of the Shares Act of
1933, as amended (the “Shares Act”), and Rule 506 under the Shares Act:




THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE
SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), AND HAVE BEEN ISSUED AND SOLD IN
RELIANCE UPON THE EXEMPTION FROM REGISTRATION PROVIDED BY SECTION 4(2) OF THE ACT
AND RULE 506 PROMULGATED UNDER THE ACT. THESE SECURITIES HAVE BEEN ACQUIRED FOR
INVESTMENT AND NOT WITH A VIEW TO DISTRIBUTION OR RESALE, AND MAY NOT BE TRANSFERRED
WITHOUT AN EFFECTIVE REGISTRATION STATEMENT FOR SUCH SECURITIES UNDER THE SECURITIES
ACE OF 1933, AS AMENDED, OR PURSUANT TO RULE 144 UNDER SUCH ACT OR AN OPINION OF
COUNSEL SATISFACTORY TO THE COMPANY THAT REGISTRATION IS NOT REQUIRED UNDER THE ACT.


The Company will deliver the Certificate in such denomination as requested by the Purchaser against
delivery of payment for the Shares by the Purchaser.




          3.3 Company’s Obligation to Close. The Company’s obligation to complete the purchase
and sale of the Shares shall be subject to the following conditions, any one or more of which may
be waived in writing by the Company:



               (a) receipt by the Company of same-day funds in the full amount of the purchase price for the
Shares being purchased under this Agreement; and



               (b) the accuracy in all material respects of the representations and warranties made by the
Purchaser and the fulfillment in all material respects of those undertakings of the Purchaser to be
fulfilled before the Closing.



          3.4 Purchaser’s Obligation to Close. The Purchaser’s obligations to accept delivery
of such stock certificates and to pay for the Shares shall be subject to the following conditions,
any one or more of which may be waived in writing by the Purchaser:




               (a) the representations and warranties made by the Company in this Agreement shall be accurate
in all material respects and the undertakings of the Company shall have been fulfilled in all
material respects on or before the Closing;



               (b) there shall have been no suspension of trading or listing of the Company’s shares of
Common Stock on the NASDAQ National Market or NASDAQ Capital Market, as applicable;



               (c) the Company shall have delivered to the Purchaser a certificate executed by its Chief
Executive Officer and Chief Financial Officer, dated as of the Closing Date, in substantially the
form attached hereto as Exhibit A, to the effect that the representations and



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warranties of the Company set forth in Section 6 hereof are true and correct in all material
respects as of the date of this Agreement and as of the Closing Date, and that the Company has
complied in all material respects with all the agreements and satisfied all the conditions in this
Agreement on its part to be performed or satisfied on or before the Closing Date; and



               (d) Wilson Sonsini Goodrich & Rosati, PC, counsel to the Company, shall have delivered a
legal
opinion to the Purchaser in substantially the form attached as Exhibit C hereto.



     4. Registration Rights.



          4.1 Piggy-Back Registration.




               (a) If, at any time prior to the date which is two (2) years from the date hereof, the
Company
proposes to file with the SEC a registration statement relating to an offering of any of its
securities for its own account or the account of security holders exercising their demand
registration rights (other than on Form S-4 or Form S-8 or their then equivalents relating to
securities to be issued solely in connection with an acquisition of any entity or business or
equity securities issuable in connection with stock option or other employee benefit plans) (a
“Registration Statement”), the Company shall promptly send to the Purchaser written notice
of the Company’s intention to file such a registration statement and of such Purchaser’s rights
under this Section 4.2 and, if within fifteen (15) days after receipt of such notice, such
Purchaser shall so request in writing, the Company shall include in such registration statement all
or any part of the Shares (such outstanding Shares referred to as the “Registrable
Securities” for purposes of this Section 4) such Purchaser requests to be registered.



               (b) The Company shall bear and pay all expenses incurred in connection with any registration,
filing or qualification of Registrable Securities with respect to the registrations pursuant to
Section 4.1, including all registration, filing, and qualification fees, printers and accounting
fees relating or apportionable thereto, and the reasonable fees and expenses of counsel for
Purchaser.



               (c) If the registration of which the Company gives notice is for a registered public offering
involving an underwriting, the Company shall so indicate in the notice given pursuant to this
Section 4.1. In such event the right of any Purchaser to registration pursuant to this Section 4.1
shall be conditioned upon Purchaser’s agreeing to participate in such underwriting and in the
inclusion of such Purchaser’s Registrable Securities in the underwriting to the extent provided
herein. The Purchaser shall (together with the Company and the other holders distributing their
securities through such underwriting) enter into an underwriting agreement in customary form with
the underwriter or underwriters selected for such underwriting by the Company or by other holders
exercising any demand registration rights. Notwithstanding any other provision of this Section
4.1, if the underwriter determines that marketing factors require a limitation of the number of
shares to be underwritten, the underwriter may exclude some or all Registrable Securities or other
securities from such registration and underwriting (hereinafter an “Underwriter Cutback”).
In the event of an Underwriter Cutback, the Company shall so advise the Purchaser and the other
holders distributing their securities through such underwriting, and the number of Registrable
Securities that



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may be included in the registration and underwriting shall be allocated in proportion, as
nearly as practicable, to the respective amounts of Registrable Securities held by the Purchaser at
the time of filing the registration statement. If the Purchaser disapproves of the terms of any
such underwriting, the Purchaser may elect to withdraw therefrom by written notice to the Company
and the underwriter. Any securities excluded or withdrawn from such underwriting shall be
withdrawn from such registration.



          4.2 Indemnification. In the event any Registrable Securities are included in
Registration Statement under this Section 4:




               (a) To the extent permitted by law, the Company will indemnify and hold harmless the
Purchaser, each of the Purchaser’s officers, directors and agents, each person who participates in
the offering of the Registrable Securities, including underwriters (as defined in the Securities
Act) and each person, if any, who controls the Purchaser (or other participating person) within the
meaning of the Securities Act or the Securities Exchange Act of 1934 (the “Exchange Act”),
against any losses, claims, damages, or liabilities (joint or several) to which they may become
subject under the Securities Act, the Exchange Act, or other federal or state law, insofar as such
losses, claims, damages, or liabilities (or actions in respect thereof) arise out of or are based
upon any of the following statements, omissions or violations (collectively a “Violation”):
(i) any untrue statement or alleged untrue statement of a material fact contained in such
registration statement, including any preliminary prospectus or final prospectus contained therein
or any amendments or supplements thereto, including any information deemed to be a part thereof as
of the time of effectiveness pursuant to paragraph (b) of Rule 430A, or pursuant to Rule 434, of
the Rules and Regulations, or the prospectus, in the form first filed with the SEC pursuant to Rule
424(b) of the Regulations, or filed as part of the Registration Statement at the time of
effectiveness if no Rule 424(b) filing is required (the “Prospectus”), or any amendment or
supplement thereto (ii) the omission or alleged omission to state therein a material fact required
to be stated therein, or necessary to make the statements therein not misleading, or (iii) any
violation or alleged violation by the Company of the Securities Act, the Exchange Act, any state
securities law or any rule or regulation promulgated under the Securities Act, or the Exchange Act,
or any state securities law; and the Company will pay to the Purchaser or controlling person, any
legal or other expenses reasonably incurred by them in connection with investigating or defending
any such loss, claim, damage, liability, or action; provided, however, that the indemnity agreement
contained in this subsection 4.2(a) shall not apply to amounts paid in settlement of any such loss,
claim, damage, liability, or action if such settlement is effected without the consent of the
Company (which consent shall not be unreasonably withheld), nor shall the Company be liable in any
such case for any such loss, claim, damage, liability, or action to the extent that it arises out
of or is based upon the Company’s reliance upon written information furnished expressly for use in
connection with such registration by the Purchaser or an officer, director or agent thereof,



               (b) To the extent permitted by law, the Purchaser will, if Registrable Securities held by such
Purchaser are included in the registration, indemnify and hold harmless the Company, each of its
directors, each of its officers who has signed the registration statement, each person, if any, who
controls the Company within the meaning of the Act, against any losses, claims, damages, or
liabilities (joint or several) to which any of the foregoing persons may become subject, under the
Securities Act, the Exchange Act, or other federal, state law, insofar as such losses, claims,



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damages, or liabilities (or actions in respect thereto) arise out of or are based upon the
Company’s reliance upon written information furnished by the Purchaser expressly for use in
connection with such registration; and the Purchaser will pay, as incurred, any legal or other
expenses reasonably incurred by the Company, in connection with investigating or defending any such
loss, claim, damage, liability, or action; provided however, that the indemnity agreement contained
in this subsection 4.2(b) shall not apply to amounts paid in settlement of any such loss, claim,
damage, liability or action if such settlement is effected without the consent of the Purchaser,
which consent shall not be unreasonably withheld; provided, further, that the amount of the
indemnity shall be limited to the proceeds of sale received by such Purchaser unless such indemnity
obligation arises from a Purchaser’s commission of fraud or intentional misrepresentation.



               (c) Promptly after receipt by an indemnified party under this Section 4.2 of notice of the
commencement of any action (including any governmental action), such indemnified party will, if a
claim in respect thereof is to be made against any indemnifying party under this Section 4.2,
deliver to the indemnifying party a written notice of the commencement thereof and the indemnifying
party shall have the right to participate in, and, to the extent the indemnifying party so desires,
jointly with any other indemnifying party similarly noticed, to assume the defense thereof with
counsel mutually satisfactory to the parties; provided, however, that an indemnified party
(together with all other indemnified parties which may be represented without conflict by one
counsel) shall have the right to retain one separate counsel, with the fees and expenses to be paid
by the indemnifying party, if representation of such indemnified party by the counsel retained by
the indemnifying party would be inappropriate due to actual or potential differing interests
between such indemnified party and any other party represented by such counsel in such proceeding.
The failure to deliver written notice to the indemnifying party within a reasonable time of the
commencement of any such action, if prejudicial to its ability to defend such action, shall relieve
such indemnifying party of any liability to the indemnified party under this Section 4.2, but the
omission so to deliver written notice to the indemnifying party will not relieve it of any
liability that it may have to any indemnified party otherwise than under this Section 4.2.



               (d) If the indemnification provided for in this Section 4.2 is held by a court of
competent
jurisdiction to be unavailable to an indemnified party with respect to any loss, liability, claim,
damage, or expense referred to therein, then the indemnifying party, in lieu of indemnifying such
indemnified party hereunder, shall contribute to the amount paid or payable by such indemnified
party as a result of such loss, liability, claim, damage, or expense in such proportion as is
appropriate to reflect the relative fault of the indemnifying party on the one hand and of the
indemnified party on the other in connection with the statements or omissions that resulted in such
loss, liability, claim, damage, or expense as well as any other relevant equitable considerations.
The relative fault of the indemnifying party and of the indemnified party shall be determined by
reference to, among other things, whether the untrue or alleged untrue statement of a material fact
or the omission to state a material fact relates to information supplied by the indemnifying party
or by the indemnified party and the parties’ relative intent, knowledge, access to information, and
opportunity to correct or prevent such statement or omission.



               (e) The obligations of the Company and Purchaser under this Section 4.2 shall survive the
completion of any offering of Registrable Securities in a registration statement, as applicable,
under this Section 4, and otherwise.



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          4.3 Further Obligations of the Company. Without limiting the generality of the
foregoing or of Section 7.10 hereof, whenever required under this Section 4 to effect the
registration of the Shares, the Company shall, as expeditiously and as reasonably possible:




               (a) Keep the Purchaser advised as to the initiation of each registration, qualification and
compliance and as to the completion thereof and furnish the Purchaser with a copy of each
Registration Statement, or supplement or amendment thereto, filed with the SEC.



               (b) Promptly furnish to the Purchaser a draft Registration Statement, as applicable, and
copies of all such documents proposed to be filed therewith.



               (c) As promptly as practicable after becoming aware of such event, notify the Purchaser in
writing of the happening of any event as a result of which the prospectus included in a
Registration Statement, as then in effect, includes an untrue statement of a material fact or
omission to state a material fact required to be stated therein or necessary to make the statements
therein, in light of the circumstances under which they were made, not misleading, and promptly
prepare a supplement or amendment to such Registration Statement to correct such untrue statement
or omission, and deliver a copy of such supplement or amendment to the Purchaser (or such other
number of copies as the Purchaser may reasonably request). The Company shall also promptly notify
the Purchaser in writing (i) when a prospectus or any prospectus supplement or post-effective
amendment has been filed, and when a Registration Statement or any post-effective amendment has
become effective (notification of such effectiveness shall be delivered to the Purchaser by
facsimile on the same day of such effectiveness and by overnight mail), (ii) of any request by the
SEC for amendments or supplements to a Registration Statement or related prospectus or related
information, and (iii) of the Company’s reasonable determination that a post-effective amendment to
a Registration Statement would be appropriate.



               (d) Notify the Purchaser within a reasonable time upon (i) the receipt by the Company of
any
notification with respect to the issuance by the SEC of any stop order suspending the effectiveness
of such registration statement or prospectus or any amendment or supplement thereto or the
initiation or threatening of any proceeding for that purpose or (ii) the receipt by the Company of
any notification with respect to the suspension of the qualification of the securities covered by
such registration statement, for sale in any jurisdiction or the initiation or threatening of any
proceeding for such purposes.



               (e) Use its best efforts to prevent the issuance of any stop order or other suspension of
effectiveness of a registration statement, or the suspension of the qualification of any of the
Registrable Securities for sale in any jurisdiction and, if such an order or suspension is issued,
to obtain the withdrawal of such order or suspension at the earliest possible moment and to notify
the Purchaser of the issuance of such order and the resolution thereof or its receipt of actual
notice of the initiation or threat of any proceeding for such purpose.



               (f) If requested by the Purchaser, the Company shall (i) immediately incorporate in a
prospectus supplement or post-effective amendment such information as the Purchaser agrees should
be included therein relating to the sale and distribution of Registrable Securities, including,
without limitation, information with respect to the offering of the Registrable



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Securities to be sold in such offering; (ii) make all required filings of such prospectus
supplement or post-effective amendment as soon as notified of the matters to be incorporated in
such prospectus supplement or post-effective amendment; and (iii) supplement or make amendments to
any Registration Statement or the related prospectus if requested by the Purchaser. In the event
of: (1) any request by the SEC or any other federal or state governmental authority during the
period of effectiveness of the Registration Statement for amendments or supplements to a
Registration Statement or related prospectus or for additional information, (2) the issuance by the
SEC or any other federal or state governmental authority of any stop order suspending the
effectiveness of a Registration Statement or the initiation of any proceedings for that purpose,
(3) the receipt by the Company of any notification with respect to the suspension of the
qualification or exemption from qualification of any of the Registrable Securities for sale in any
jurisdiction or the initiation of any proceeding for such purpose, or (4) any event or circumstance
which necessitates the making of any changes in the Registration Statement or Prospectus, or any
document incorporated or deemed to be incorporated therein by reference, so that, in the case of
the Registration Statement, it will not contain any untrue statement of a material fact or any
omission to state a material fact required to be stated therein or necessary to make the statements
therein not misleading, and that in the case of the Prospectus, it will not contain any untrue
statement of a material fact or any omission to state a material fact required to be stated therein
or necessary to make the statements therein, in the light of the circumstances under which they
were made, not misleading, then the Company shall deliver a certificate in writing to the Purchaser
(the “Suspension Notice”) to the effect of the foregoing (which notice will not disclose
the content of any material non-public information and will indicate the date of the beginning and
end of the intended period of suspension, if known), and, upon receipt of such Suspension Notice,
the Purchasers will discontinue disposition of Registrable Securities covered by to the
Registration Statement or Prospectus (a “Suspension”) until the Purchasers’ receipt of
copies of a supplemented or amended Prospectus prepared and filed by the Company, or until the
Purchasers are advised in writing by the Company that the current Prospectus may be used, and have
received copies of any additional or supplemental filings that are incorporated or deemed
incorporated by reference in any such prospectus. In the event of any Suspension, the Company will
use its commercially reasonable efforts to cause the use of the Prospectus so suspended to be
resumed as soon as possible after delivery of a Suspension Notice to the Purchasers. The
Suspension and Suspension Notice described in this Section 4.3(f) shall be held in strictest
confidence and shall not be disclosed by the Purchasers.



               (g) In the event of any underwritten public offering, enter into and perform its obligations
under an underwriting agreement, in usual and customary form, with the managing underwriter of such
offering including, without limitation causing to be furnished to the Purchaser (i) a “cold
comfort” letter of the Company’s independent accountants as of the effective date of the
registration statement as to such matters as customarily are covered in accountant’s letters
delivered to underwriters in underwritten public offerings and (ii) an opinion of counsel to the
Company, as of the date of the closing of such underwritten public offering, in the form
customarily provided by issuer’s counsel in underwritten public offerings of securities. The
Purchaser shall also enter into and perform its obligations under such an agreement.



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               (h) The Company shall otherwise use its best efforts to comply with all applicable rules and
regulations of the SEC in connection with any registration hereunder.



     5. Representations, Warranties and Covenants of the Company. Except as set forth on the
Schedule of Exceptions attached hereto as Exhibit B, the Company hereby represents and
warrants to the Purchaser as follows (which representations and warranties shall be deemed to
apply, where appropriate, to each subsidiary of the Company):



          5.1 Organization and Qualification. The Company has been duly incorporated and is
validly existing as a corporation in good standing under the laws of the State of Delaware. The
Company has the corporate power and authority to own, lease and operate its properties and to
conduct its business as currently conducted and to enter into and perform its obligations under
this Agreement. The Company is duly qualified as a foreign corporation to transact business and is
in good standing in each jurisdiction in which such qualification is required, whether by reason of
the ownership or leasing of property or the conduct of business, except where the failure to so
qualify would not, singly or in the aggregate, have an adverse effect on the condition, financial
or otherwise, or the earnings, assets or business affairs of the Company.




          5.2 Capitalization.




               (a) The authorized capital stock of the Company consists of 80,000,000 shares of Common Stock
and 5,000,000 shares of Preferred Stock.



               (b) As of June 30, 2006, the issued and outstanding capital stock of the Company consists
of
36,075,017 shares of Common Stock. The shares of issued and outstanding capital stock of the
Company have been duly authorized and validly issued, are fully paid and nonassessable and have not
been issued in violation of any state or federal laws, rules or regulations, or in violation of
(and are not otherwise subject to) any preemptive or other similar rights.



               (c) As of June 30, 2006, the Company has reserved 911,519 shares of Common Stock for
issuance
upon the exercise of stock options granted or available for future grant under the Company’s stock
option plan.



               (d) As of June 30, 2006, the Company has reserved 2,200,000 shares of Common Stock for
issuance upon the exercise of warrants held by Quest Diagnostics Incorporated.



               (e) As of June 30, 2006, the Company has reserved 260,612 shares of Common Stock for
purchase
under the Company’s Employee Stock Purchase Plan.



               (f) As of June 30, 2006, the Company has reserved 25,000 shares of Common Stock for
potential
issuance to Gail Page, President and Chief Executive Officer of the Company, contingent upon the
achievement of a specific diagnostic milestone.



               (g) As of June 30, 2006 there are 3,264,987 shares of Common Stock reserved for potential
issuance upon conversion of certain outstanding 4.5% Convertible Senior Notes due September 1,
2008.



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With the exception of the foregoing, there are no outstanding subscriptions, options, warrants,
convertible or exchangeable securities or notes, or other rights granted to or by the Company to
purchase shares of Common Stock or other securities of the Company and there are no commitments, or
agreements to issue any shares of Common Stock or any security convertible into or exchangeable for
Common Stock.




          5.3 Issuance, Sale and Delivery of the Shares.




               (a) The Shares have been duly authorized for issuance and sale to the Purchaser pursuant to
this Agreement and, when issued and delivered by the Company pursuant to this Agreement against
payment of the consideration set forth in this Agreement, will be validly issued, fully paid and
nonassessable, and free and clear of all pledges, liens and encumbrances. The Certificates
evidencing the Shares are in due and proper form under Delaware law.



               (b) The issuance of the Shares is not subject to preemptive or other similar rights. No
further approval or authority of the stockholders or the board of directors of the Company will be
required for the issuance and sale of the Shares to be sold by the Company as contemplated in this
Agreement.



               (c) Subject to the accuracy of the Purchaser’s representations and warranties in
Section 7 of
this Agreement, the offer, sale, and issuance of the Shares in conformity with the terms of this
Agreement constitute transactions exempt from the registration requirements of Section 5 of the
Shares Act and from the registration or qualification requirements of the laws of any applicable
state or United States jurisdiction (including under NASD rules and regulations).



          5.4 No Defaults. The Company is not in violation of its certificate of incorporation
or bylaws or in material default in the performance or observance of any obligation, agreement,
covenant or condition contained in any contract filed as an exhibit to the Company Documents (as
defined below) pursuant to Item 601 of Regulation S-K under the Shares and Exchange Acts, or any
other material contract, indenture, mortgage, loan agreement, deed, trust, note, lease, sublease,
voting agreement, voting trust or other instrument or material agreement to which the Company is a
party or by which it may be bound.



          5.5 Due Execution, Delivery and Performance. This Agreement has been duly executed
and delivered by the Company and constitutes a valid and binding obligation of the Company,
enforceable against the Company in accordance with its terms. The execution, delivery and
performance of this Agreement and the consummation of the transactions contemplated in this
Agreement and the fulfillment of the terms of this Agreement have been duly authorized by all
necessary corporate action and will not conflict with or constitute a breach of, or default under,
or result in the creation or imposition of any lien, charge or encumbrance upon any property or
assets of the Company pursuant to, any contract, indenture, mortgage, loan agreement, deed, trust,
note, lease, sublease, voting agreement, voting trust or other instrument or agreement to which the
Company is a party or by which it may be bound, or to which any of the property or assets of the
Company is subject, and will not trigger anti-dilution rights or other rights to acquire additional
equity securities of the Company, nor will such action result in any violation of the provisions of
the articles of



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incorporation or bylaws of the Company or of any applicable statute, law, rule, regulation,
ordinance, decision, directive or order.



          5.6 Governmental Consents. No registration, authorization, approval, qualification or
consent of any court or governmental authority or agency or self-regulatory organization, including
the National Association of Shares Dealers (the “NASD”), is necessary in connection with the
execution and delivery of this Agreement or the offering, issuance or sale of the Shares under this
Agreement, except exemptive filings under applicable federal and state securities laws.



          5.7 Additional Information. The Company represents and warrants that the information
contained in the following documents (the “Company Documents”) is or will be true and
correct in all material respects as of their respective final dates:



               (a) the Company’s annual report on Form 10-K for the fiscal year ended December 31,
2005;



               (b) the Company’s quarterly report on Form 10-Q for the fiscal quarter ended
March 31, 2006;
and



               (c) all other documents, if any, filed by the Company with the SEC since March 31, 2006
pursuant to the reporting requirements of the Exchange Act.



          5.8 No Change. Since the filing with the SEC of the Company Documents (i) the Company
has not incurred any material liabilities or material obligations, indirect, or contingent, or
entered into any material oral or written agreement or other transaction which is not in the
ordinary course of business and which could reasonably be expected to cause a material adverse
change in the future earnings of the Company; (ii) the Company has not sustained any material loss
or interference with its businesses or properties from fire, flood, windstorm, accident or other
calamity not covered by insurance; (iii) the Company has not paid or declared any dividends or
other distributions with respect to its capital stock and the Company is not in default in the
payment of principal or interest on any outstanding debt obligations; and (iv) there has not been
any change in the capital stock of the Company other than the sale of the Shares hereunder and
shares or options issued pursuant to the Company’s stock option plan or employee stock purchase
plan and any options outstanding as of the date hereof, or indebtedness, liens or claims (other
than in the ordinary course of business).



          5.9 No Actions. Except as disclosed in the Company Documents, there are no legal or
governmental actions, suits or proceedings pending or threatened to which the Company is or may be
a part or of which property owned or leased by the Company is or may be the subject, or related to
environmental or discrimination matters, which actions, suits or proceedings, individually or in
the aggregate, might prevent or might reasonably be expected to materially and adversely affect the
transactions contemplated by this Agreement; and no labor disturbance by the employees of the
Company exists, or is threatened which might reasonably be expected to have a material adverse
effect. Except as disclosed in the Company Documents, the Company is not a party to or subject to
the provisions of any injunction, judgment, decree or order of any court, regulatory body



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administrative agency or other governmental body which could reasonably be expected to cause a
material adverse change in the future earnings of the Company.



          5.10 Compliance. To the Company’s knowledge, it is conducting its business in
compliance with all applicable laws, rules and regulations of the jurisdictions in which it is
conducting business, including, without limitation, all applicable local, state and federal
environmental laws and regulations, the violation of which could reasonably be expected to cause a
material adverse change in the future earnings of the Company.



          5.11 Intellectual Property. Except as disclosed in the Company Documents (i) the
Company believes it has the necessary trademark, trade name rights, patent rights, copyrights,
licenses, trade secret and other intellectual property rights to conduct its business as it is
being conducted as of the date hereof and as specifically described in the Company Documents; and,
(ii) the Company has no knowledge of any infringement by it of trademark, trade name rights, patent
rights, copyrights, trade secret or any other intellectual property rights of third parties, or of
any claim made against the Company regarding such an infringement, that in each case would be
expected to have a material adverse effect on the Company.



          5.12 Investment Company. The Company is not an “investment company” or an “affiliated
person” of, or “promoter” or “principal underwriter” for an investment company, within the meaning
of the Investment Company Act of 1940, as amended.



          5.13 Reporting Company; Listed Shares. The Company is a reporting company and has
filed all reports required to be filed by Sections 13(a), 14(a) or 15(d) of the Exchange Act, as
amended, in a timely manner during the preceding twelve (12) months and has been subject to such
filing requirements for the past twelve (12) months. The Common Stock is quoted on the Nasdaq
National Market System (“NASDAQ”).



     6. Representations, Warranties and Covenants of the Purchaser.



          6.1 Shares Law Representations and Warranties. The Purchaser represents, warrants and
covenants to the Company as follows:




               (a) The Purchaser is knowledgeable, sophisticated and experienced in making, and is qualified
to make, decisions with respect to investments in shares representing an investment decision like
that involved in the purchase of the Shares, and has requested, received, reviewed and considered
all information it deems relevant in making an informed decision to purchase the Shares.



               (b) The Purchaser is acquiring the number of Shares set forth in Section 1 above in the
ordinary course of its business and for its own account for investment only and has no present
intention of distributing any of the Shares nor any arrangement or understanding with any third
parties regarding the distribution of such Shares within the meaning of Section 2(11) of the Shares
Act; provided, however, that in making such representation, such Purchaser does not agree to hold
the Shares for any minimum or specific term and reserves the right to sell, transfer or otherwise



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dispose of the Shares at any time in accordance with the provisions of this Agreement and with
Federal and state securities laws applicable to such sale, transfer or disposition.



               (c) The Purchaser will not, directly or indirectly, offer, sell, pledge, transfer or otherwise
dispose of (or solicit any offers to buy, purchase or otherwise acquire or take a pledge of) any of
the Shares except in compliance with the Shares Act and the rules and regulations promulgated
thereunder.



               (d) The Purchaser has, in connection with its decision to purchase the number of Shares set
forth in Section 2 above, relied solely upon the Company Documents, the representations and
warranties of the Company contained in this Agreement, and the legal opinion rendered by the
Company’s counsel.



               (e) The Purchaser is an “accredited investor” within the meaning of Rule 501 of
Regulation D
promulgated under the Shares Act.



          6.2 Due Execution, Delivery and Performance.




               (a) This Agreement has been duly executed and delivered by the Purchaser and constitutes a
valid and binding obligation of the Purchaser, enforceable against the Purchaser in accordance with
its terms.



               (b) The execution, delivery and performance of this Agreement and the consummation of the
transactions contemplated in this Agreement and the fulfillment of the terms of this Agreement have
been duly authorized by all necessary corporate action.



     7. Miscellaneous.



          7.1 Survival of Representations, Warranties and Agreements. Notwithstanding any
investigation made by any party to this Agreement, all representations and warranties made by the
Company and the Purchaser in this Agreement, in the certificates for the Shares shall survive for
one (1) year from the execution of this Agreement.



          7.2 Notices. All notices, requests, consents and other communications under this
Agreement shall be in writing, shall be mailed by first-class registered or certified airmail,
confirmed facsimile or nationally recognized overnight express courier postage prepaid, and shall
be delivered as addressed as follows:



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(a)     If to the Company, to:


Ciphergen Biosystems, Inc.

6611 Dumbarton Circle

Fremont, California 94555

Attn: President and Chief Executive Officer

Telephone: (510) 505-2100

Facsimile: (510) 505-2101





With a copy to:


Wilson Sonsini Goodrich & Rosati, PC

650 Page Mill Road

Palo Alto, California 94304

Attn: Michael O’Donnell, Esq.

Telephone: (650) 493-9300

Facsimile: (650) 493-6811




     or to such other person at such other place as the Company shall designate to the Purchaser in
writing; and



If to the Purchaser, to:



Bio-Rad Laboratories, Inc.

1000 Alfred Nobel Drive

Hercules, California 94547

Attn: General Counsel

Telephone: (510) 741-6005

Facsimile: (510) 741-5815



Such notice shall be deemed effectively given upon confirmation of receipt by facsimile, two
business days after deposit with such overnight courier.




          7.3 Modification; Amendment. This Agreement may not be modified or amended except
pursuant to an instrument in writing signed by the Company and Purchaser.




          7.4 Headings. The headings of the various sections of this Agreement have been
inserted for convenience of reference only and shall not be deemed to be part of this Agreement.




          7.5 Severability. If any provision contained in this Agreement should be held to be
invalid, illegal or unenforceable in any respect, the validity, legality and enforceability of the
remaining provisions contained in this Agreement shall not in any way be affected or impaired
thereby.




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          7.6 Governing Law. This Agreement shall be governed by and construed in accordance
with the laws of the state of Delaware, without regard to its rules regarding conflicts of law, and
the federal law of the United States of America.




          7.7 Counterparts. This Agreement may be executed in two or more counterparts, each of
which shall constitute an original, but all of which, when taken together, shall constitute but one
instrument, and shall become effective when one or more counterparts have been signed by each party
to this Agreement and delivered to the other party.




          7.8 Entire Agreement. This Agreement constitutes the entire agreement between the
parties hereto with respect to the subject matter hereof. There are no restrictions, promises,
warranties or undertakings other than those set forth or referred to herein. This Agreement
supersedes all prior agreements and understandings between the parties hereto with respect to the
subject matter hereof.




          7.9 Waiver. Failure of either party to exercise any right or remedy under this
Agreement or otherwise, or delay by a party in exercising such right or remedy, shall not operate
as a waiver thereof.




          7.10 Further Assurances. Each party shall do and perform, or cause to be done and
performed, all such further acts and things, and shall execute and deliver all such other
agreements, certificates, instruments and documents, as the other party may reasonably request in
order to carry out the intent and accomplish the purposes of this Agreement and the consummation of
the transactions contemplated hereby.




          7.11 No Broker’s Fee. The Company shall not pay any broker’s or finder’s fee or
commission, and there are no brokers or finders entitled to receive compensation in connection with
the transaction contemplated herein.




     In Witness Whereof, the parties have caused this Agreement to be executed by their authorized
representatives.



	 	 	 	 	 	 	 	 	 	 	 
	BIO-RAD LABORATORIES, INC.	 	 	 	CIPHERGEN BIOSYSTEMS, INC.	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	By: 

Name:

	 	/s/ Norman Schwartz
 

Norman Schwartz
	 	 
	 	By:

Name:
	 	/s/ Debra Young
 

Debra Young
	 	 
	Its:

	 	President
	 	 	 	Its:
	 	Chief Financial Officer and

Vice President of Finance	 	 






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