EX-10.10





 Exhibit 10.10 

AMENDMENT NO. 2 
 TO

 LOAN AND SECURITY AGREEMENT 

THIS AMENDMENT NO. 2 TO LOAN AND SECURITY AGREEMENT (this “No.2 Amendment”) is made and entered into as of November 3,
2021, by and among Heart Test Laboratories, Inc., a Texas corporation, (the “Company”), Front Range Ventures LLC, a Wyoming limited liability company, or its assigns (“FRV”), and John Q. Adams, a Texas resident, or
his assigns, (“JQA”) (FRV and JQA each a “Lender” and together the “Lenders”) as defined in the Original Agreement (as defined below). 

WITNESSETH: 
 WHEREAS, the
Company, the Lenders (collectively, the “Parties”) have previously entered into that certain Loan and Security Agreement dated on or around April 24, 2020 (the “Original Agreement”) and Amendment No. 1 to
the Loan and Security Agreement dated September 30, 2021 (“No.1 Amendment”) (together the “Loan Agreement”); and 

WHEREAS, the Company desires to further extend the Maturity Date as provided in the Loan Agreement to September 30, 2022; and 

WHEREAS, in consideration for Lender’s agreement to further extend the Maturity Date, the Company shall issue to each Lender a warrant as
specifically provided in those certain Warrant Agreements between the Company and each Lender and dated as of the date hereof. 
 NOW,
THEREFORE, in consideration of the foregoing, and the representations, warranties, covenants and conditions set forth herein, the Loan Agreement, and the other Transaction Agreements, the Company and the Lenders, intending to be legally bound,
hereby agree as follows: 
 Section 1. Capitalized Terms. Except as otherwise provided herein, capitalized terms used in this
No.2 Amendment shall have the meaning set forth in the Loan Agreement. 
 Section 2. Amendment. The Section 3.1 of the Loan
Agreement is hereby amended to read, in its entirety, as follows: 
 “3.1 Maturity Date. The outstanding Principal Amount,
together with all Accrued Interest thereon, shall be due and payable on September 30, 2022 (the “Maturity Date”). All payments and other charges due under the Transaction Agreements shall be made in lawful currency of the
United States of America.” 












 Section 3. Release of Claims Against Lenders. 

THE COMPANY, BY SIGNING THIS No.2 AMENDMENT, HEREBY ABSOLUTELY AND UNCONDITIONALLY RELEASES AND FOREVER DISCHARGES LENDERS AND ANY AND ALL OF
THEIR PARENT COMPANIES, SUBSIDIARY COMPANIES, AFFILIATED COMPANIES, INSURERS, INDEMNITORS, SUCCESSORS AND ASSIGNS TOGETHER WITH ALL OF THEIR RESPECTIVE PRESENT AND FORMER MANAGERS, DIRECTORS, OFFICERS, AGENTS AND EMPLOYEES FROM ANY AND ALL CLAIMS,
DEMANDS OR CAUSES OF ACTION OF ANY KIND, NATURE OR DESCRIPTION, WHETHER ARISING IN LAW OR EQUITY OR UPON CONTRACT OR TORT OR UNDER ANY STATE OR FEDERAL LAW OR OTHERWISE, WHICH THE COMPANY HAS HAD, NOW HAS, OR HAS MADE CLAIM TO HAVE AGAINST ANY SUCH
PARTY FOR OR BY REASON OF ANY ACT, OMISSION, MATTER, CAUSE OR THING WHATSOEVER ARISING FROM THE BEGINNING OF TIME TO AND INCLUDING THE DATE OF THIS AMENDMENT, WHETHER SUCH CLAIMS, DEMANDS AND CAUSES OF ACTION ARE MATURED OR UNMATURED OR KNOWN OR
UNKNOWN. 
 Section 4. Execution in Several Counterparts. This No.2 Amendment may be executed in several counterparts or by
separate instruments and by facsimile transmission and all of such counterparts and instruments shall constitute one agreement, binding on all of the Parties hereto. 

Section 5. Headings. The headings in this No.2 Amendment are for convenience of reference only and shall not limit or otherwise
affect the meaning hereof. 
 Section 6. Governing Law. The laws of the State of Texas shall govern this No.2 Amendment without
regard to principles of conflict of laws. 
 Section 7. Original Agreements. Except as expressly amended by this No.2 Amendment,
the Transaction Agreements shall remain in full force and effect and all of the terms of the Transaction Agreements are hereby incorporated into this No.2 Amendment. 

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 IN WITNESS WHEREOF, the undersigned have executed this No.2 Amendment as of the day
and year first above written. 
  

			
	COMPANY:
	
	HEART TEST LABORATORIES, INC.
		
	By:	 	 /s/ Andrew Simpson

	Printed:	 	 Andrew Simpson

	Title:	 	 Chairman

	
	LENDER:
	
	FRONT RANGE VENTURES, LLC.
		
	By:	 	 /s/ Loren J. Richards

	Printed:	 	 Loren J. Richards

	Title:	 	 First Western Trust Bank, Trust Offier

	
	LENDER:
	
	JOHN Q. ADAMS
		
	By:	 	 /s/ John Q. Adams Sr.

	Printed:	 	 John Q. Adams Sr.

	Title: