BUSINESS PROTECTION AGREEMENT
                                  [EXECUTIVES]

In  consideration  of  employment  by  EPITOPE,   INC.,  or  its   subsidiaries,
affiliates,  successors  or assigns  (collectively  referred to as  "Employer"),
William Block ("Employee") agrees as follows:

1.       NEED FOR EMPLOYER PROTECTION.

Employee recognizes and acknowledges that:

         (a)  In the course of performing  his/her  duties for Employer,  he/she
will have access to  Confidential  Information,  the ownership and  confidential
status of which are highly important to the Company.  Employee also acknowledges
that  except as  otherwise  specifically  provided  for in this  Agreement  such
Confidential Information is and shall continue to be the exclusive and permanent
property  of the  Company,  whether  or not  prepared  in  whole  or in  part by
Employee,  and whether or not  disclosed or entrusted to Employee in  connection
with his/her duties for Employer.  Confidential  Information shall not be deemed
disclosed  to the public due to its being  disclosed to Employee or to any past,
present, or potential employees of the Company.

         (b) Employer has a vital and  substantial  interest in maintaining  the
confidentiality  of its Confidential  Information,  in maintaining a stable work
force, in continuing its relationships with its Corporate Contacts, in remaining
in  business,  and in  avoiding  or  minimizing  any  disruption  of,  damage or
impairment to, or interference with its business.

         (c) The Confidential  Information and Corporate  Contacts that Employee
will obtain as a result of his/her employment hereunder is special and unique to
Employer,  and a breach by  Employee of any of the terms and  covenants  of this
Agreement will result in irreparable  and continuing  harm to Employer for which
there will be no  adequate  remedy at law and for which the injury  could not be
adequately compensated by money damages.

2.       CONFIDENTIAL INFORMATION

As used in this Agreement,  the term  "Confidential  Information" shall mean any
information  of  Employer,  (including  any  parent,  subsidiary,   predecessor,
successor,  or otherwise affiliated  corporation,  partnership or other business
enterprise,  hereinafter collectively referred to as the "Company"),  whether or
not in written form,  which has not been  previously  disclosed to the public by
the  Company  and which (1) is either  designated  or treated by the  Company as
confidential  or proprietary or as a trade secret,  (2) the Company is obligated
to keep  confidential  because it has been  provided by third parties or (3) the
Employee knows or should know is  confidential.  Consistent  with the definition
set forth above, the term "Confidential  Information" shall include,  but is not
limited to, the Company's: trade secrets;  proprietary information;  inventions,
discoveries,  or  improvements;  methods of  conducting  or obtaining  business,
including  methods  of  marketing;  non-public  lists of actual  or  prospective
clients,  customers,  suppliers,  vendors or  investors  provided to Employee by
Employer  or  developed  or learned  by  Employee  while  employed  by  Employer
(collectively  "Corporate  Contacts");  corporate  documents,  plans or manuals;
software and data; finances;  legal affairs; labor or other reports;  current or
future  business  opportunities;  current  or  future  products  or  technology;
formulae, processes,  machines, or compositions;  relationships with third party
companies; the terms of Employer's agreements with Corporate Contacts; and other
information marked, designated and/or treated by the Company as confidential.

3.       SCOPE OF EMPLOYER PROTECTION

Employer is a  multi-national  concern  that does  business  all over the United
States as well as in foreign  countries.  In his/her  employment  with Employer,
Employee may perform services in more than one city,  county,  state or country,
and may gain access to  Confidential  Information  that pertains not only to the
specific  area in which  Employee  lives and/or works but also to other  cities,
counties,  states and countries in which  Employer does  business.  The Employer
protections stated herein are intended to protect Employer to the fullest extent
possible in all of the cities, counties, states, and countries in which Employer
does business.

Employer and Employee expressly  acknowledge and agree that each of the Employer
protections  stated herein is intended to be as broad as may be permitted  under
the provisions of applicable law. Employer and Employee further


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acknowledge  and  agree  that  if any  of  the  protections  herein  are  deemed
unenforceable,  the  unenforceability  of any one or more  Employer  protections
stated herein (or any portion thereof),  shall not affect the  enforceability of
any other protection (or portion thereof) stated herein.

4.       NONDISCLOSURE OF CONFIDENTIAL INFORMATION

Employee shall hold all  Confidential  Information  in a fiduciary  capacity and
shall  exercise  the  highest  degree  of  care  in  safeguarding   Confidential
Information against loss, theft, or other inadvertent disclosure, and shall take
all steps reasonably necessary to maintain the confidentiality thereof. Employee
shall not, directly or indirectly,  either during the term of his/her employment
(except as required in the course of the performance of her/his  duties),  or at
any time after her/his employment is terminated for any reason:

         (a) Disclose or furnish to any person, corporation or other entity, use
in his/her own or in any other person's business, any Confidential Information;

         (b)  Utilize any such Confidential Information for the gain, advantage,
or profit of anyone other than Employer; or

         (c)  Take  advantage  of any  business  opportunity  which,  because of
Confidential  Information  obtained in  Employee's  employment  capacity or as a
result of his/her  employment,  Employee  knows the  Company may or is likely to
consider.

If  Employee  is  served  with any  subpoena  or other  compulsory  judicial  or
administrative  process  calling for  production  of  Confidential  Information,
Employee  will  immediately  notify  Employer in order that the Company may take
such action as it deems necessary to protect its interests.

5.       NONCOMPETITION

For one year after  termination  of  employment  employee  shall not directly or
indirectly,  own, operate,  provide financial,  technical or other assistance or
services to, accept any  involvement  with, or be connected  with as an officer,
partner,  proprietor,  consultant,  representative,  agent or stockholder (other
than as an owner of less than 5% of the  stock of a  publicly  held  corporation
whose   stock  is  traded  on  a  national   securities   exchange   or  in  the
over-the-counter  market)  any  organization  which  engages in the  business of
researching, manufacturing, marketing or distributing products for oral specimen
based medical testing or HIV testing.

         (a)  Due to the fact that  Employer  does  business all over the world,
this  covenant not to compete  shall apply  within 50 miles of any  geographical
area in which  Employer  actively  conducted  business or actively  contemplated
doing business during any period of Employee's employment with Employer.

         (b)  During  the  term  of  his/her  employment  and  the  term of this
covenant not to compete,  Employee shall inform any potential employer, prior to
accepting employment, of this covenant not to compete and provide such potential
employer with a copy thereof.

         (c)  The one year  restriction  period set forth in  Paragraph 5A shall
not have the effect of  diminishing  or reducing the  period(s)  of  restriction
contained in any other provision of this BPA.

6.       NON-SOLICITATION OF EMPLOYEES/CONTRACTORS

         (a)  Unless Employee  receives the prior express written consent of the
Employer,  Employee  shall not during the term of Employee's  employment and for
one year after termination of his/her  employment,  induce or attempt to induce,
directly or by assisting  others,  any person who is in the employment of, or is
providing services to, the Employer to leave such employment or engagement.

         (b)  If  Employee  violates  Paragraph  (1)  above,  then  at the  sole
election of Employer, Employee shall pay to Employer $10,000 for each identified
employee. This remedy, if elected by Employer, shall be in addition to any other
remedies provided to Employer under this BPA or by law.

7.       NON-PROVISION OF SERVICES TO CORPORATE CONTACTS


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         (a)  Unless Employee  receives the prior,  express,  written consent of
Employer,  Employee shall not, during the term of Employee's  employment and for
one year after termination of her/his employment,  solicit or accept, or attempt
to solicit or accept,  directly  or by  assisting  others,  any work,  services,
goods, or other business from any of Corporate  Contacts of Employer (as defined
above).

         (b)  If Employee violates this Section above, then at the sole election
of Employer,  Employee  shall pay to Employer  fifty percent (50%) of the actual
fees billed or billable to such Corporate  Contacts  during that period of time.
This remedy, if elected by Employer,  shall be in addition to any other remedies
provided to Employer under this BPA or by law.

8.       WORK FOR HIRE

Employee agrees that all creative work,  including without  limitation  designs,
drawings,  specifications,   techniques,  models,  and  processes,  prepared  or
originated by Employee during or within the scope of employment,  whether or not
subject to protection  under federal  copyright or other law,  constitutes  work
made for hire,  all rights to which are owned by  Employer;  and,  in any event,
employee  hereby assigns to Employer all right,  title and interest,  whether by
way of copyright,  trade secret, or otherwise,  in all such work, whether or not
subject to protection by copyright or other law.

9.       DISCLOSURE OF PRIOR RESTRICTIONS

Employee  understands that Employer is not employing Employee in order to obtain
any  information  that is the  property of any  previous  employers or any other
person or entity for whom Employee has performed  services.  Employee represents
that he/she is not currently  subject to any  restriction  that would prevent or
limit Employee from carrying out his/her duties for Employer.  Employee  further
represents  that he/she will not disclose or provide any information to Employer
(a) relating to any inventions,  discoveries, or improvements excluded from this
Agreement  which  Employer  shall not be free to use without  restriction or (b)
which,  if used by  Employer,  would  cause  Employer to infringe or violate the
rights of any person, including without limitation, Employee.

10.      OTHER LEGAL RIGHTS OF EMPLOYER

The rights and duties of  Employer  and  Employee  under this  Agreement  are in
addition to, and not in lieu of, those rights and duties afforded to and imposed
upon  them by law,  or at  equity.  The  parties  acknowledge  that  although  a
condition of continued employment, this Agreement does not constitute a contract
of employment, nor does it entitle Employee to employment for any specific term.
All of Employer's employees are employees "at-will" unless specifically provided
otherwise by written agreement.

11.      BREACH

In the  event of  breach  of any of the  terms or  covenants  contained  in this
Agreement,  Employee agrees that Employer shall be entitled to temporary  and/or
permanent  injunctive  relief upon a showing that  Employee  has  breached  this
Agreement  without proof of actual damage and without  posting a bond therefore,
against the Employee and any of the Employee's  partners,  agents,  employers or
employees,  or any persons  acting for or with the Employee,  and/or an order of
temporary specific performance enforcing this Agreement, and any other temporary
and/or permanent remedies provided to Employer by applicable law. Such temporary
and/or  permanent  relief  shall remain in effect until the matter in dispute is
permanently resolved.

12.      SEVERABILITY OF PROVISIONS

The provisions of this Agreement are severable,  and if any provision  hereof is
held invalid or  unenforceable  the remaining  provision of this Agreement shall
not be affected thereby.

13.      SUCCESSORS, HEIRS, ASSIGNEES OR NOMINEES

This Agreement  shall inure to the benefit of and be binding upon Employer,  its
successors,  assigns or nominees and also upon Employee,  his/her estate,  heirs
and  assigns.  Employee's  contractual  obligations  under  this  Agreement  are
personal and neither  Employee's  rights or obligations under this Agreement may
be assigned or transferred.  Employer's rights and obligations,  however, may be
assigned or transferred.

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14.      WAIVER

No  provision  of this  Agreement  may be waived by  either  party,  except by a
writing  signed by that party.  The waiver of any portion of this Agreement with
respect to any person or  invention  shall be  construed  narrowly and shall not
affect the right of the party granting the waiver to enforce any other provision
of this  Agreement or to enforce any provision of this Agreement with respect to
any other person or invention.

15.      REFERENCES TO GENDER

Any reference to this Agreement to the masculine  gender shall also be deemed to
refer to the feminine gender.

16.      OREGON LAW TO BE APPLIED

The  interpretation of and performance under this Agreement shall be governed by
the laws of the State of  Oregon,  without  giving  effect to its  choice of law
principles.

17.      ATTORNEY FEES

In the event of a default  under this  Agreement,  the  defaulting  party  shall
reimburse the nondefaulting party for all costs and expenses reasonably incurred
by the  nondefaulting  party in connection with the default,  including  without
limitation,  attorney  fees. In addition,  the  prevailing  party in any suit or
action to enforce  this  Agreement,  or any term  hereof,  shall be  entitled to
recover  all its costs and  expenses  incurred in  connection  with such suit or
action, including,  without limitation,  reasonable attorneys' fees, arbitration
costs, and other legal costs incurred at all levels and proceedings.

18.      VENUE/JURISDICTION

For all disputes under this Agreement, the parties agree that any suit or action
between them shall be instituted  and commenced  exclusively  in the local state
courts in Multnomah County, or the United States District Court for the District
of Oregon,  sitting in  Portland.  Both  parties  waive the right to change such
venue and hereby  consent to the  jurisdiction  of such courts for all potential
claims under this Agreement.

19.      TERM OF THIS AGREEMENT

This Agreement shall continue until no longer applicable.  For example, by their
stated  terms,  the  non-competition,   non-solicitation  and  non-provision  of
services   provisions  apply  for  one  year  after  termination  of  Employee's
employment.  Also,  for example,  the  non-disclosure  obligations  set forth in
Paragraphs 1-4 of this Agreement will continue  beyond the term of employment of
Employee  and  until  the  covered  information  is  released  to the  public by
Employer.



X  William D. Block                                          4/20/99
 -------------------------------------               -----------------------
           Employee Signature                                  Date


X  Maureen Haggerty                                          4/26/99
 -------------------------------------               -----------------------
           Witness Signature                                  Date


Witness's Address: (omitted)
                  --------------------------------------------------------------

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