Exhibit 4.18

       

      Pursuant to 17 CFR 229.601(b)(10)(iv), confidential information (indicated by [***]) has been omitted from this exhibit because it is both not material and would likely cause competitive harm to the
        registrant if publicly disclosed.

       

      EXCLUSIVE DISTRIBUTION AGREEMENT

       

      This Exclusive Distribution Agreement (the “Agreement”) is made as of this 23rd day of June,
        2020 (the “Effective Date”), between Chiasma, Inc., a Delaware corporation, with an address of 140 Kendrick Street, Building C East, Needham, Massachusetts 02494 (“Client”),
        and Cardinal Health 105, Inc., an Ohio corporation, with a place of business at 501 Mason Road, Suite 200, La Vergne, Tennessee, 37086 (“Cardinal Health”) each individually a (“Party”) and collectively (the “Parties”).

       

      RECITALS

       

      A.         Client is, among other things, in the business of developing and marketing pharmaceutical products in the United States, its territories, possessions and commonwealths (“Territory”).

       

      B.            Cardinal Health is, among other things, in the business of distributing pharmaceutical products to wholesalers, specialty distributors, physicians, clinics, hospitals, pharmacies, and
        other health care providers in the Territory, and of providing information systems and other services that support its clients’ use of its distribution capabilities.

       

      C.         Client desires to engage Cardinal Health as its exclusive third-party logistics distribution agent for commercial sales in the Territory of all pharmaceutical Products manufactured
        and/or marketed by Client in all formulations (collectively, “Product”), and to perform certain other services described in this Agreement, all upon the terms and conditions set forth in this Agreement.

       

      THEREFORE, in consideration of the mutual covenants, terms and conditions set forth below, the Parties agree as follows:

       

      ARTICLE 1

      APPOINTMENT/AUTHORIZATION

       

      1.1         Appointment.  Subject to the terms and conditions set forth in this Agreement, during the
        term of this Agreement, Client appoints Cardinal Health as its exclusive third-party logistics distribution agent and as an authorized distributor of record of Product in the Territory to Client’s Customers, including, but not limited to,
        wholesalers, specialty distributors, physicians, clinics, hospitals, pharmacies and other health care providers in the Territory (collectively, “Customers”).

       

      1.2         Acceptance of Appointment.  Subject to the terms and conditions set forth in this
        Agreement, Cardinal Health accepts the appointment to represent Client as its exclusive third-party logistics distribution agent and as an authorized distributor of record of Product to Customers in the Territory.

       

       

      
        
          	
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      ARTICLE 2

      SERVICES

       

      2.1        Services.   Cardinal Health shall provide the services set forth in the Traditional
        3PL Operating Guidelines (“OPG”), which include, without limitation, storage, distribution, returns, customer support, financial support, EDI and system access support (“Services”). 
        The OPG shall be finalized and mutually agreed upon prior to the commercial launch of Product.  Once finalized, a copy of the OPG shall be attached hereto as Exhibit A and incorporated by reference.

       

      2.2        Traditional 3PL Operating Guidelines.  The OPG may be amended from time to time upon the
        mutual written agreement of the Parties; provided, however, that any change, modification or amendment to the OPG may result in an increase in the Fees (as defined in Article 5).

       

      2.3         Compliance to Traditional 3PL Operating Guidelines.  Cardinal Health’s services shall
        comply with the OPG for up to [***] of Client’s Forecast (defined below).  If (i) Client’s shipments of Product to Cardinal Health or (ii) Client’s Customers’ Product orders exceed Client’s Forecast by more than [***], Cardinal Health shall use
        commercially reasonable efforts to meet the requirements of the OPG, provided however, that Client acknowledges that Cardinal Health may not be able to meet all guidelines relating to response and shipping times for those excess shipments and
        orders.

       

      2.4         Product Returns.  All Product returns shall be processed and handled by Cardinal Health in
        accordance with the OPG; and any customization or additional return services requested by Client shall be performed at an additional fee as agreed by the Parties.

       

      2.5        Product Recalls.  Client is solely responsible for all Product recalls, provided however
        that Cardinal Health shall be responsible for Product recalls to the extent arising from Cardinal Health’s gross negligence or willful misconduct, subject to the terms of this Agreement.  In the event Product is subject to recall, or Client, on its
        own initiative, recalls any Product, Cardinal Health shall provide assistance to Client as set forth in the OPG and as mutually agreed upon, provided that Client shall pay to Cardinal Health an amount equal to Cardinal Health’s actual costs
        incurred with any such recall services, except to the extent arising from Cardinal Health’s gross negligence or willful misconduct.  Such cost shall be in addition to the Fees described in Article 5 below.

       

      ARTICLE 3

      PRODUCT SUPPLY/CLIENT RESPONSIBILITIES

       

      3.1        Facility.  Client shall deliver Product to Cardinal Health at Cardinal Health’s facility
        located at 15 Ingram Boulevard, La Vergne, Tennessee 37086 and/or 501 Mason Road, Suite 200, La Vergne, Tennessee 37086, or to such other distribution facility as may be designated by Cardinal Health to Client in writing (“3PL Facility”).

       

      3.2        Delivery and Title.  Client shall be responsible for delivery of Product to and from the 3PL
        Facility, including all costs, expenses and risk of loss associated with such delivery.  Title to Product shall remain with Client at all times, even when Product is stored or warehoused at the 3PL Facility.  Client shall at all times insure the
        Product for damage, loss, destruction, theft or any such other property damage (“Loss”) as further set forth in Article 13 below.  Except for Loss resulting solely from the gross negligence or willful
        misconduct of Cardinal Health, Client shall bear all risk of loss or damage with respect to the Product; provided that Cardinal Health shall use the same degree of care to protect any Product stored or warehoused at the 3PL Facility as it uses to
        protect its own assets and properties, but no less than a reasonable degree of care.

       

      
        
          	
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      3.3         Forecast and Price List.

       

      A.           Forecast.  Client shall provide Cardinal Health with a forecast of the volume of Product to be
          handled by Cardinal Health under this Agreement, not less often than [***] (“Forecast”).  All forecasts, including the Forecast, are used for
          the express purpose of operational planning.  In the event of a significant variance from the Forecast or a change in core business that could reasonably be expected to have a material effect upon the obligations of either Party hereunder, the
          Party so affected may notify the other Party that it wishes to negotiate an appropriate adjustment to the Fees.  The Parties must meet within [***] days of such notification to discuss the merits and implementation of any such adjustment and
          during such meeting, the Parties shall negotiate in good faith.  If the Parties are unable to come to a resolution regarding any such adjustment, the Party originally proposing the adjustment may terminate this Agreement upon [***] prior written
          notice to the other Party.

       

      B.          Price List.  Upon execution of this Agreement, Client shall deliver to Cardinal Health a customer
          list, which sets forth the Product prices (the “Customer Price List”).  Client shall notify Cardinal Health of any change in the Customer Price
          List not less than [***] hours prior to the effective date of any such change.  Cardinal Health shall use commercially reasonably efforts to implement such price change in accordance with Client’s instruction.

       

      3.4        Shipment Inspection.  Cardinal Health shall visually inspect each shipment of Product for
        external damage or loss in transit and promptly (but in any event within [***] business days) notify Client of any such evident damage or loss as provided in the OPG.

       

      ARTICLE 4

      INFORMATION SYSTEM ACCESS

       

      4.1        Access.  During the Term of this Agreement and subject to the terms herein, Client may use
        password(s) and identification number(s) provided by Cardinal Health to remotely access Client’s data maintained on Cardinal Health’s web enabled Operating System Base and certain support services associated therewith, as further set forth in the
        OPG (collectively, the “System”) provided that such access is used solely by Client’s employees and independent contractors and for Client’s own internal business purposes.  Client shall use that access
        solely to access Client’s data and shall not access or attempt to access any other data, systems or software.  Client shall be responsible for all use of the passwords and identification elements by Client’s employees and independent contractors
        and shall ensure that they are used solely to effect the limited access authorized herein.  The limited license to access the System granted herein does not include the right to copy, download or otherwise use any software or non-Client data
        maintained on the System.

       

      4.2      Fees.  The System shall be made available to Client at the fees set forth in the Fee
        Schedule.  If Cardinal Health agrees to perform any custom enhancements to the System requested by Client, such customization services shall be billed separately based on an hourly rate set forth in the Fee Schedule (as defined in Article 5) and
        prior to such performance, Cardinal Health and Client shall agree upon any related increase in the periodic Fees hereunder relative to the ongoing support of the customizations.

       

      
        
          	
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      4.3        Security.   During the term of this Agreement and for so long thereafter as Client’s data
        resides on the System, Cardinal Health shall employ reasonable security measures and policies designed to safeguard the integrity, accessibility, and confidentiality of Client’s data resident on the System and establish and maintain reasonable
        disaster and emergency recovery plans designed to minimize disruption from System operation interruptions.  Such measures shall be no less secure than those utilized by Cardinal Health to protect its own confidential information but shall reflect
        no less than a reasonable degree of care.

       

      4.4        Client Obligations.  Client shall not reverse engineer, reverse assemble, decompile,
        create derivative works, modify, or otherwise attempt to derive the source code of any software on the System or copy, download, modify, or create derivative works of such software.  Also, Client shall not permit access to the System or related
        documentation to any other person or entity other than its employees and independent contractors.  The System and all parts thereof, in all of their tangible and intangible manifestations, all existing or new enhancements, developments, derivative
        works, and other modifications to the System (or any part thereof), and all related proprietary rights, are and shall remain the exclusive property of Cardinal Health.

       

      4.5        Disclaimer.  THE SYSTEM, THE SOFTWARE THEREON AND ANY
          RESULTS OBTAINED THEREFROM ARE PROVIDED ON AN “AS IS” BASIS, WITHOUT WARRANTY OF ANY KIND, WHETHER EXPRESS, IMPLIED, STATUTORY OR OTHERWISE, EXCEPT AS EXPRESSLY SET FORTH IN THIS AGREEMENT.  EXCEPT AS EXPRESSLY SET FORTH IN THIS AGREEMENT,
          CARDINAL HEALTH MAKES NO REPRESENTATIONS OR WARRANTIES, AND HEREBY EXPRESSLY DISCLAIMS ALL REPRESENTATIONS AND WARRANTIES, EXPRESS OR IMPLIED, RELATING DIRECTLY OR INDIRECTLY TO THE SYSTEM OR ANY PART THEREOF INCLUDING WITHOUT LIMITATION
          WARRANTIES OF MERCHANTABILITY, NONINFRINGEMENT AND FITNESS FOR A PARTICULAR PURPOSE.

       

      4.6         System Availability.   Cardinal Health shall use reasonable efforts to make the System
        available for access twenty-four (24) hours a day, seven (7) days a week absent scheduled and emergency maintenance periods as set forth in the OPG.

       

      4.7         Suspension of Access.  Notwithstanding anything to the contrary, in the event of a material
        breach of any term of this Agreement or a threatened breach of the System, Cardinal Health may revoke or suspend any or all passwords and identification numbers provided to Client hereunder, for the period of time reasonably necessary for Cardinal
        Health to resolve the matter, provided that Cardinal Health shall otherwise provide access to Client’s data to Client during such period of revocation or suspension by promptly responding to Client’s request for such data by e-mail or facsimile.

       

      
        
          	
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      ARTICLE 5

      PRICING AND PAYMENT TERMS

       

      5.1        Fees.  As compensation for the Services, Client shall pay to Cardinal Health the fees (“Fees”) set forth on Exhibit B (“Fee Schedule”) attached hereto and incorporated by reference.

       

      5.2        Invoices.  Cardinal Health shall issue an invoice to Client for the Services rendered under
        this Agreement or for any other amounts due on a [***] basis.  Payment is due within [***] days of the invoice date via electronic funds transfer (EFT) or Automated Clearing House (ACH).  If the invoice is not paid within such [***] day period,
        Cardinal Health may, at its option elect to (i) impose a service charge on the unpaid amount calculated at the rate of [***] per month (or the maximum rate permitted by law if such rate is less than [***] per month) until such amount is paid in
        full and/or (ii) suspend any further Services until such invoice is paid in full; provided, however, that this provision shall not apply in the event any unpaid
        portion of the invoice is the subject of an unresolved good faith dispute.  In the event of any good faith dispute with regard to an invoice, Client shall notify Cardinal Health of such dispute within [***] days of the invoice date, and any
        undisputed portion of the invoice shall be paid as provided herein.  The Parties will work together in good faith to resolve any dispute with respect to an invoice.  Any amounts owed to Cardinal Health shall be paid within [***] days of resolution
        of such dispute.

       

      5.3         Fee Adjustment.

       

      A.          The Fees shall be held firm for [***].  Thereafter, Cardinal Health will evaluate the fee schedule and may
          adjust the Fees not more often than [***] per contract year by not more than [***] over the Fees for the prior contract year.

       

      B.         Notwithstanding the terms set forth above in Section 5.3(A), if Cardinal Health can reasonably demonstrate
          that the costs for providing the Services have materially increased, or are likely to materially increase in the coming year due to the adoption of any applicable law or regulation (or any material change in the interpretation or administration
          thereof), or due to unforeseen circumstances beyond Cardinal Health’s reasonable control, then upon notice from Cardinal Health not more often than [***] per contract year, the Parties agree to meet in good faith and negotiate a mutually
          acceptable adjustment to the Fees.

       

      5.4        Taxes.  Client shall pay when due to the appropriate taxing authority all sales, use, gross
        receipts, excise and personal property taxes associated with the Product (excluding any personal property tax associated with Cardinal Health’s equipment used in connection with the Services), and other taxes now or hereafter imposed as a result of
        the transactions contemplated by this Agreement, none of which have been included in the fees payable to Cardinal Health under this Agreement; provided that the amounts payable by Client under this section shall not include taxes based on the net
        income of Cardinal Health.

       

      ARTICLE 6

      TERM AND TERMINATION

       

      6.1        Term.  The Initial Term of this Agreement shall begin on the Effective Date and shall
        continue for a period of [***] years following the first shipment of FDA-approved Product to a commercial customer (“Initial Term”), unless terminated earlier pursuant to this Agreement.  Thereafter, this
        Agreement shall automatically renew for additional terms of one (1) year each (each, a “Renewal Term,” and together with the Initial Term, the “Term”), unless written
        notice of termination is given by either Party at least [***] days prior to the end of the Initial Term or any Renewal Term.

       

      
        
          	
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      6.2         Termination.  Either Party shall have the right to immediately terminate this Agreement
        upon written notice to the other if:

       

      (A)         the other Party files a petition in bankruptcy, or enters into an agreement with its creditors, or applies
          for or consents to the appointment of a receiver or trustee, or makes an assignment for the benefit of creditors, or suffers or permits the entry of any order adjudicating it to be bankrupt or insolvent and such order is not discharged within
          [***] days;

       

      (B)         the other Party materially breaches any of the provisions of this Agreement, and such breach is not cured
          within [***] days after the giving of written notice; provided, however, that (i) in the case of a breach that cannot be cured within [***] days, the Parties agree to meet in good faith and within [***] days after the giving of written notice,
          formulate a mutually agreeable plan to cure such breach within a reasonable period of time; provided further that the non-breaching party may nonetheless terminate this Agreement if such breach is not cured within [***] days after the giving of
          written notice, or if the breaching party fails at any point to diligently implement the agreed-upon plan to cure such breach; and (ii) in the case of a failure of Client to make payments in accordance with the terms of this Agreement, Cardinal
          Health may terminate this Agreement if such payment breach is not cured within [***] days following Cardinal Health’s delivery of a written notice of non-payment to Client; or

       

      (C)          as and when permitted to do so pursuant to the terms of Section 15.15 (Force Maj cure).

       

      In addition, Client shall have the right to terminate this Agreement upon written notice to Cardinal Health in the event of (x) Cardinal Health’s material breach of the OPG in respect of safe handling instructions
        that is not cured within [***] days of the notice, or (y) any Product recall arising from Cardinal Health’s gross negligence or willful misconduct.

       

      6.3        Effect of Termination.  Expiration or termination of this Agreement shall be without
        prejudice to any rights or obligations that accrued to the benefit of either Party prior to such expiration or termination.  Client shall pay Cardinal Health for all Services performed up to the date of termination and shall reimburse Cardinal
        Health for all costs and expenses incurred, and all non-cancelable commitments made, in the performance of Services.  Upon termination or expiration of this Agreement, all Product and all Client funds not otherwise applied to outstanding Fees,
        costs and expenses otherwise payable to Cardinal Health shall be promptly returned to Client or a designee of Client, at Client’s sole cost and expense.

       

      ARTICLE 7

      REGULATORY

       

      7.1        Audits.  No more than [***] per calendar year, Client or its designee has the right during
        normal business hours [i.e., 8:00 a.m. to 5:00 p.m. local 3PL Facility time and not to exceed a total of eight (8) business hours], to conduct a complete quality audit upon [***] business days prior written notice to Cardinal Health.  If the timing
        of such audit falls during “quarter-end” or “year-end” then Cardinal Health will use best efforts to accommodate Client’s request.  Client shall have the right to
        conduct for cause audits immediately if necessary, to ensure Product safety or if otherwise necessary to implement or support a Product recall.

       

      
        
          	
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      7.2        Compliance with Laws.  Each Party shall conduct its activities in connection with this
        Agreement in compliance with all applicable United States laws, rules, regulations and guidelines.

       

      ARTICLE 8

      REPRESENTATIONS AND WARRANTIES

       

      8.1         Cardinal Health.  Cardinal Health represents and warrants to Client that, unless otherwise
        agreed to by the Parties, Cardinal Health shall perform Services in accordance with this Agreement, the OPG, and applicable United States laws, rules, regulations and guidelines.

       

      8.2         Client.  Client represents, warrants and covenants to Cardinal Health that:

       

      A.            Product.  The Product shall not be adulterated or misbranded as provided in the Food, Drug and
          Cosmetic Act, as amended from time to time;

       

      B.          Promotion.  Client’s activities relating to the promotion, sale and distribution of the Product
          shall comply with all applicable laws, rules, regulations and guidelines;

       

      C.           No Infringement.  It has all necessary authority and right, title and interest in and to any
          intellectual property related to each Product or that is otherwise provided by Client under this Agreement; and

       

      D.           Safe Handling Instructions.  It has provided all safe handling instruction, health and
          environmental information and material safety data sheets deemed by Client to be applicable to the Product or to any materials supplied by Client in writing or in electronic or digital media or format in sufficient time for review and training by
          Cardinal Health prior to delivery.

       

      8.3         Mutual.  Each Party represents and warrants to the other Party that:

       

      A.           Existence and Power.  Such Party (i) is duly organized, validly existing and in good standing under
          the laws of the state in which it is organized, (ii) has the power and authority and the legal right to own and operate its property and assets, and to carry on its business as it is now being conducted, and (iii) is in compliance with all
          requirements of applicable laws, except to the extent that any noncompliance would not materially adversely affect such Party’s ability to perform its obligations under the Agreement;

       

      B.            Authorization and Enforcement of Obligations.  Such Party (i) has the power and authority and the
          legal right to enter into this Agreement and to perform its obligations hereunder and (ii) has taken all necessary action on its part to authorize the execution and delivery of this Agreement and the performance of its obligations hereunder;

       

      
        
          	
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      C.           Execution and Delivery.  This Agreement has been duly executed and delivered on behalf of such
          Party, and constitutes a legal, valid, binding obligation, enforceable against such Party in accordance with its terms, except as such enforceability may be limited by bankruptcy, insolvency, reorganization, moratorium or similar laws affecting
          creditors’ rights generally and by general principles of equity (regardless of whether enforcement is sought in a proceeding at law or in equity);

       

      D.           No Consents.  All necessary consents, approvals and authorizations of all regulatory authorities
          and other persons required to be obtained by such Party in connection with the Agreement have been obtained; and

       

      E.            No Conflict.  The execution and delivery of this Agreement and the performance of such Party’s
          obligations hereunder (i) do not conflict with or violate any requirement of applicable laws; and (ii) do not materially conflict with or constitute a material default or require any consent under, any contractual obligation of such Party.

       

      8.4     Limitations.  THE REPRESENTATIONS AND WARRANTIES SET FORTH IN THIS ARTICLE 8 ARE THE SOLE AND
        EXCLUSIVE REPRESENTATIONS AND WARRANTIES MADE BY EACH PARTY TO THE OTHER AND NEITHER PARTY MAKES ANY OTHER REPRESENTATIONS, WARRANTIES OR GUARANTEES OF ANY KIND WHATSOEVER, INCLUDING WITHOUT LIMITATION ANY IMPLIED WARRANTIES OF MERCHANTABILITY,
        NON-INFRINGEMENT OR FITNESS FOR A PARTICULAR PURPOSE.

       

      ARTICLE 9

      TRADEMARKS

       

      Neither Party shall have the right to use the name of the other Party or any Affiliate of the other Party, or the other Party’s or such Affiliates’ trademarks, service marks, logos, or other similar marks (the “Marks”) in any manner except with the prior written approval of that Party; provided that the foregoing shall not prohibit Cardinal Health’s use of Client’s Marks in connection with the performance of the
        Services in a manner consistent with this Agreement; provided further that (i) neither Cardinal Health nor any of its Affiliates shall remove or deface any Client Marks appearing on the Products or on any documentation provided by Client hereunder,
        (ii) upon termination for any reason or expiration of this Agreement, the license set forth in this Section in respect of Client’s Marks shall immediately terminate, (iii) at no time during or after the term of this Agreement shall Cardinal Health
        or any of its Affiliates challenge or assist others to challenge Client’s Marks or use or attempt to register any trademarks, service marks or trade names confusingly similar to those of Client’s Marks in any jurisdiction or country, (iv) all
        representations of Client’s Marks and visual branding that Client authorizes for Cardinal Health or any of its Affiliates to use shall be used only in accordance with Client’s instructions, and (v) neither Cardinal Health nor any of its Affiliates
        shall gain any right or interest in or to the Client Marks other than for the limited license expressly granted in this Section, and all Client Marks shall remain the sole and exclusive property of the Client.  “Affiliate,”

        as used in this Agreement, means any legal entity which, during the Term hereof, controls, is controlled by, or is under common control with, such Party.  For purposes of this definition, an entity shall be deemed to control another entity if it
        owns or controls, directly or indirectly, at least fifty percent (50%) of the voting interest of all equity interests of the other entity (or other such comparable ownership interest for an entity other than a corporation).

       

      
        
          	
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      ARTICLE 10

      CONFIDENTIALITY AND NON-USE

       

      10.1      Mutual Obligation.  Cardinal Health and Client agree that they shall not use the other
        Party’s Confidential Information (defined below) except as necessary for the receiving Party to perform its obligations under this Agreement or disclose the other Party’s Confidential Information to any third party without the prior written consent
        of the other Party except as required by law, regulation or court or administrative order; provided, however, that prior to making any such legally required disclosure, the Party making such disclosure shall give the other Party as much prior
        notice of the requirement for and contents of such disclosure as is practicable under the circumstances so that the other Party may seek, prior to disclosure, and at the other Party’s sole expense, a protective order or other appropriate remedy. 
        If, failing the entry of a protective order hereunder, the Party making such disclosure is, in the advice of its legal counsel, legally compelled to disclose Confidential Information of the other Party, only that portion of such Confidential
        Information that is legally required to be disclosed shall be so disclosed; provided, that the Party making such disclosure shall exercise its commercially reasonable efforts to seek confidential treatment of such Confidential Information. 
        Notwithstanding the foregoing, each Party may disclose the other Party’s Confidential Information to any of its Affiliates that (A) need to know such Confidential Information for the purpose of performing under this Agreement, (B) are advised of
        the contents of this article, and (C) agree to be bound by the terms of this article; provided that such Party shall remain primarily liable for such Affiliate’s breach of such terms.  The receiving Party shall use the same degree of care to
        protect Confidential Information of the other Party as it uses to protect its own Confidential Information, but no less than a reasonable degree of care.

       

      10.2       Definition.  As used in this Agreement, the term “Confidential
          Information” includes all such information furnished by Cardinal Health or Client, or any of their respective representatives or Affiliates, to the other or its representatives or Affiliates in connection with the services or performance
        of this Agreement, whether furnished before, on or after the date of this Agreement and furnished in any form, including but not limited to written, verbal, visual, electronic or in any other media or manner.  Confidential Information includes all
        proprietary technologies, know-how, trade secrets, discoveries, inventions and any other intellectual property (whether or not patented), analyses, compilations, business or technical information and other materials prepared by either Party, or any
        of their respective representatives, containing or based in whole or in part on any such information furnished by the other Party or its representatives.  Confidential Information also includes the existence of this Agreement and its terms.

       

      10.3       Exclusions.  Notwithstanding Section 10.2, Confidential Information does not include
        information that (A) is or becomes generally available to the public other than as a result of a breach of this Agreement, or (B) is already known by the receiving Party at the time of disclosure as evidenced by the receiving Party’s written
        records, or (C) becomes available to the receiving Party on a non-confidential basis from a source that is entitled to disclose it on a non-confidential basis, or (D) was or is independently developed by or for the receiving Party without reference
        to the Confidential Information, as evidenced by the receiving Party’s written records.

       

      10.4       No Implied License.  The receiving Party shall obtain no right of any kind or license under
        any patent application or patent by reason of this Agreement.  All Confidential Information shall remain the sole property of the Party disclosing such information or data.

       

      
        
          	
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      10.5      Return of Confidential Information.   Upon termination or expiration of this
        Agreement, the receiving Party shall, upon request, promptly return within [***] days all such information, including any copies thereof, and cease its use or, at the request of the disclosing Party, shall promptly destroy the same and certify such
        destruction to the disclosing Party; except for a single copy thereof, which may be retained for the sole purpose of determining the scope of the obligations incurred under this Agreement.

       

      10.6       Survival.  The Parties intend for this Article 10 to supersede that certain Confidentiality
        Agreement between the parties dated the 10th day of September, 2019.  The obligations of this Article 10 shall terminate [***] years from the expiration of this Agreement.

       

      ARTICLE 11

      INDEMNIFICATION

       

      11.1     Indemnification by Cardinal Health.  Cardinal Health shall indemnify and hold harmless Client,
        its Affiliates, and their respective directors, officers, employees and agents (“Client Indemnitees”) from and against any and all suits, claims, losses, demands, liabilities, damages, costs and expenses
        (including reasonable attorney’ fees) in connection with any suit, demand or action by any third party (“Liabilities”) arising out of or resulting from (A) any breach of its representations, warranties or
        obligations set forth in this Agreement or (B) any negligence or willful misconduct by Cardinal Health, except to the extent that any of the foregoing arises out of or results from any Client Indemnitee’s negligence, willful misconduct or breach of
        this Agreement.

       

      11.2       Indemnification by Client.  Client shall indemnify and hold harmless Cardinal Health, its
        Affiliates, and their respective directors, officers, employees and agents (“Cardinal Health Indemnitees”) from and against all Liabilities arising out of or resulting
        from (A) any breach of its representations, warranties or obligations set forth in this Agreement; (B) any manufacture, sale, promotion, distribution, or shipping or the use of or exposure to the Product or any materials supplied by Client,
        including, without limitation, product liability or strict liability; (C) Client’s exercise of control over the Services to the extent that Client’s instructions or directions violate applicable law; (D) any actual or alleged infringement or
        violation of any patent, trade secret, copyright, trademark or other proprietary rights concerning the Product or any materials provided by Client; or (E) any negligence or willful misconduct by Client, except to the extent that any of the
        foregoing arises out of or results from any Cardinal Health Indemnitee’s negligence, willful misconduct or breach of this Agreement.

       

      11.3      Indemnification Procedures.  All indemnification obligations in this Agreement are
        conditioned upon the Party seeking indemnification:  (A) promptly notifying the indemnifying Party of any claim or liability of which the Party seeking indemnification becomes aware (including a copy of any related complaint, summons, notice or
        other instrument); provided, however, that failure to provide such notice within a reasonable period of time shall not relieve the indemnifying Party of any of its obligations hereunder except to the extent the indemnifying Party is prejudiced by
        such failure; (B) reasonably cooperating with the indemnifying Party in the defense of any such claim or liability (at the indemnifying Party’s expense); and (C) not compromising or settling any claim or liability without prior written consent of
        the indemnifying Party.

       

      
        
          	
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      ARTICLE 12

      LIMITATIONS OF LIABILITY

       

      12.1      OTHER THAN N RESPECT OF GROSS NEGLIGENCE OR WILLFUL MISCONDUCT, CARDINAL HEALTH’S TOTAL LIABILITY UNDER THIS AGREEMENT, FOR ANY
          AND ALL ACTS, OMISSIONS, BREACH OR NEGLIGENCE (EACH, AN “ACT”) OF CARDINAL HEALTH ARISING IN ANY CONTRACT YEAR, WHETHER IN CONTRACT OR TORT,
          INCLUDING, WITHOUT LIMITATION, ANY OF CARDINAL HEALTH’S INDEMNITY OR OTHER FINANCIAL OBLIGATIONS UNDER ARTICLE 11, SHALL NOT EXCEED THE TOTAL FEES PAID BY CLIENT TO CARDINAL HEALTH DURING THE CONTRACT YEAR (EXCLUDING PASS THROUGH EXPENSES)

      .  FOR PURPOSES OF THIS SECTION, (I) ALL LOSSES, LIABILITIES AND EXPENSES RELATING TO AN ACT (COLLECTIVELY, “LIABILITIES”) SHALL BE DEEMED TO ARISE IN THE
        CONTRACT YEAR IN WHICH CARDINAL HEALTH’S ACT THAT GAVE RISE TO THE LIABILITIES OCCURRED AND NOT WHEN THE LIABILITIES ARE ACTUALLY INCURRED BY CLIENT, AND (II) THE TERM “CONTRACT YEAR” MEANS EACH CONSECUTIVE TWELVE MONTH PERIOD BEGINNING ON THE EFFECTIVE DATE OF THIS AGREEMENT.

       

      12.2      NEITHER PARTY SHALL BE LIABLE TO THE OTHER PARTY FOR INDIRECT, INCIDENTAL, SPECIAL OR CONSEQUENTIAL DAMAGES ARISING OUT OF
          PERFORMANCE UNDER THIS AGREEMENT, INCLUDING WITHOUT LIMITATION, LOSS OF REVENUES, PROFITS OR DATA, WHETHER IN CONTRACT OR TORT, EVEN IF SUCH PARTY HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES.

       

      12.3      NOTWITHSTANDING ANYTHING TO THE CONTRARY HEREIN, THE LIMITATIONS IN THIS ARTICLE 12 SHALL NOT LIMIT CLIENT’S LIABILITY OR
          RESPONSIBILITY RELATING TO A BREACH OF ITS OBLIGATIONS UNDER SECTIONS 4.1, 4.3, AND 4.4.

       

      ARTICLE 13

      INSURANCE

       

      13.1      Insurance Policies.  During the term of this Agreement, Client shall obtain and maintain the
        following insurance with limits not less than those specified below:

       

      A.           Products and Completed Operations Liability Insurance covering the Products included in this Agreement
          with a limit of not less than $[***] per occurrence;

       

      B.            All-Risk Property Insurance, including transit coverage, in an amount equal to full replacement value
          covering Client’s property while it is at the 3PL Facility or in transit to or from the 3PL Facility.  Client’s all-risk property insurance shall apply to all losses and be primary (with respect both to any insurance issued to Cardinal Health and
          to any deductible amount or self-insured amount retained by Cardinal Health) except for losses resulting solely from the gross negligence or willful misconduct of Cardinal Health.

       

      
        
          	
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      In the event that any of the required policies of insurance are written on a claims-made basis, then such policies shall be maintained during the entire term of this Agreement and for a period of not less than [***]
        years following the termination or expiration of this Agreement.

       

      13.2     Waiver.  Client shall obtain a waiver from any insurance carrier with whom Client carries
        Property Insurance releasing its subrogation rights against Cardinal Health except for losses resulting solely from the gross negligence or willful misconduct of Cardinal Health.  Client shall not seek reimbursement for any property claim, or
        portion thereof that is not fully recovered from Client’s property insurance except for losses resulting solely from the gross negligence or willful misconduct of Cardinal Health.

       

      13.3      Additional Insured Status.  Cardinal Health, Inc., and its Affiliates shall be named as
        additional insureds under the Products and Completed Operations Liability insurance policies as respects the Products and completed operations outlined in this Agreement.  Such insurance shall be primary (with respect both to any insurance issued
        to Cardinal Health and to any self-insured amount retained by Cardinal Health) with regard to Cardinal Health’s liability for damage arising out of those products for which they have been added as additional insureds.  Such additional insurance
        status shall continue during the term and, if the policies are written on a claims-made basis, shall continue for not less than [***] years following termination or expiration of this Agreement.

       

      13.4      Certificates.  Client shall furnish certificates of insurance to Cardinal Health evidencing
        the required insurance and additional insured status as soon as practicable after the Effective Date and within [***] days after renewal of such policies.  Such certificates shall state that Client’s insurers will endeavor to provide [***] days
        written notice of any cancellation prior to the policy(ies) expiration date(s).  Each insurance policy that is required under this article shall be obtained from an insurance carrier with an A.M. Best rating of at least [***].

       

      ARTICLE 14

      NOTICES

       

      All notices and other communications hereunder shall be in writing and shall be deemed given:  (A) when delivered personally; (B) when delivered by facsimile transmission (receipt verified); (C) when received or
        refused, if mailed by registered or certified mail (return receipt requested), postage prepaid; or (D) when delivered if sent by express courier service, to the Parties at the following addresses (or at such other address for a Party as shall be
        specified by like notice; provided, that notices of a change of address shall be effective only upon receipt thereof):

       

      
        	
                To Client:

              	
                Chiasma, Inc.

                140 Kendrick Street

                Building C East

                Needham, Massachusetts 02494

                Attn:  VP, Finance

              


      

      

      

      
        
          	
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                With a copy to:

              	
                Chiasma, Inc

                140 Kendrick Street

                Building C East|

                Needham, Massachusetts 02494|

                Atm:  General Counsel

              
	 	 
	
                To Cardinal Health:

              	
                Cardinal Health 105, Inc.

                Third-Party Logistics Services

                501 Mason Road, Suite 200

                La Vergne, TN 37086

                Atm:  VP, Operations

              
	 	 
	
                With a copy to:

              	
                Cardinal Health, Inc.

                7000 Cardinal Place

                Dublin, Ohio 43017

                Attn: Associate General Counsel

                Facsimile:  (624) 757-8919

              


      

       

      ARTICLE 15

      MISCELLANEOUS

       

      15.1      Entire Agreement; Amendments.  This Agreement, the attachments and any amendments thereto
        constitute the entire understanding between the Parties and supersede any contracts, agreements or understanding (oral or written) of the Parties with respect to the subject matter hereof.  No term of this Agreement may be amended except upon
        written agreement of both Parties, unless otherwise provided in this Agreement.

       

      15.2       Captions.  The captions in this Agreement are for convenience only and are not to be
        interpreted or construed as a substantive part of this Agreement.

       

      15.3       Further Assurances.  The Parties agree to execute, acknowledge and deliver such further
        instruments and to take all such other incidental acts as may be reasonably necessary or appropriate to carry out the purpose and intent of this Agreement.

       

      15.4       No Waiver.  Failure by either Party to insist upon strict compliance with any term of
        this Agreement in any one or more instances shall not be deemed to be a waiver of its rights to insist upon such strict compliance with respect to any subsequent failure.

       

      15.5       Severability.  If any term of this Agreement is declared invalid or unenforceable by a court
        or other body of competent jurisdiction, the remaining terms of this Agreement shall continue in full force and effect.

       

      15.6     Independent Contractors.  The relationship of the Parties is that of independent contractors,
        and neither Party shall incur any debts or make any commitments for the other Party except to the extent expressly provided in this Agreement.  Nothing in this Agreement is intended to create or shall be construed as creating between the Parties
        the relationship of joint venturers, co-partners, employer/employee or principal and agent.

       

      
        
          	
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      15.7      Successors and Assigns.  This Agreement shall be binding upon and inure to the benefit of the
        Parties, their successors and permitted assigns.  Neither Party may assign this Agreement, in whole or in part, without the prior written consent of the other Party, except that either Party may, without the other Party’s consent, assign this
        Agreement to an Affiliate or to a successor to substantially all of the business or assets of the assigning company to which this Agreement relates.

       

      15.8       Governing Law.  This Agreement shall be governed by and construed under the laws of the
        State of New York, excluding its conflicts of law provisions.  The United Nations Convention on Contracts for the International Sale of Goods shall not apply to this Agreement.

       

      15.9       Dispute Resolution.  If any dispute, controversy or disagreement arises between the Parties
        (“Dispute”), such Dispute shall be presented to the respective presidents or senior executives of Cardinal Health and Client for their consideration and resolution.  If such Parties cannot reach a resolution
        of the Dispute within [***] days, either Party may submit the Dispute to a court of appropriate jurisdiction.

       

      15.10     Prevailing Party.  In any dispute resolution proceeding between the Parties in connection
        with this Agreement, the prevailing Party shall be entitled to its reasonable attorney’s fees and costs in such proceeding

       

      15.11    Counterparts.  This Agreement may be executed in one or more counterparts, each of which shall
        be deemed an original but all of which together shall constitute one and the same instrument.  Any photocopy, facsimile or electronic reproduction of the executed Agreement shall constitute an original.

       

      15.12     Publicity.  Neither Party shall make any press release or other public disclosure regarding
        this Agreement or the transactions contemplated hereby without the other Party’s express prior written consent, except as required under applicable law or by any governmental agency, in which case the Party required to make the press release or
        public disclosure shall use commercially reasonable efforts to obtain the approval of the other Party as to the form, nature and extent of the press release or public disclosure prior to issuing the press release or making the public disclosure.

       

      15.13    Setoff.  Without limiting Cardinal Health’s rights under law or in equity, Cardinal Health and
        its Affiliates, parent or related entities, collectively or individually, may exercise a right of setoff against any and all amounts due to Cardinal Health from Client.  For purposes of this section, Cardinal Health, its Affiliates, parent or
        related entities shall be deemed to be a single creditor.

       

      15.14     Survival.  The rights and obligations of the Parties shall continue under Articles 9
        (Trademarks), 10 (Confidentiality and Non-Use), to the extent expressly stated therein, 11 (Indemnification), 12 (Limitations of Liability), 13 (Insurance), 14 (Notice) 15 (Miscellaneous), 4.3 (Security) and Section 6.4 (Effect of Termination),
        notwithstanding expiration or termination of this Agreement.

       

      

      
        
          	
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      15.15     Force Majeure.  Except as to payments required under this Agreement, neither Party shall be
        liable in damages for, nor shall this Agreement be terminable or cancelable by reason of, any delay or default in such Party’s performance hereunder if such default or delay is caused by events beyond such Party’s reasonable control including, but
        not limited to, acts of God, regulation or law or other action or failure to act of any government or agency thereof, war or insurrection, civil commotion, destruction of production facilities or materials by earthquake, fire, flood or storm, labor
        disturbances, epidemic, or failure of suppliers, public utilities or common carriers; provided however, that the Party seeking relief hereunder shall immediately notify the other Party of such cause(s) beyond such Party’s reasonable control.  The
        Party that may invoke this section shall use all reasonable endeavors to promptly reinstate its ongoing obligations to the other.  If the cause(s) shall continue unabated for [***] days, then either Party may, upon written notice to the other,
        immediately terminate this Agreement.

       

      IN WITNESS WHEREOF, the undersigned have caused their duly authorized representative to execute this Agreement effective as of the date first written above.

       

      	
              CARDINAL HEALTH 105, INC,

            	 	
              CHIASMA, INC.

              

            
	 	 	 	 	 
	
              By:

            	
              /s/ Joel Wayment          

            	 	
              By:

              

            	
              /s/ Mark Fitzpatrick

            	 


      

      

      	
              Joel Wayment

            	
              Print Name:

              

            	Mark Fitzpatrick


      

      

      	
              VP, Operations

            	
              Title:

              

            	President
	 	 	 
	
              Date:

              

            	Jun 23, 2020	
              Date:

              

            	Jun 23, 2020


       

      < Signature Page to Exclusive Distribution Agreement >

       

      
        
          	
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      EXHIBIT A

       

      TRADITIONAL 3PL OPERATING GUIDELINES

       

      The OPG shall be finalized and mutually agreed upon between the Parties prior to the commercial launch of Product.  Once finalized, a copy of the OPG shall be attached hereto as Exhibit A and incorporated by
        reference.

       

       

      

      
        
          	
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