Exhibit 12.1

Volcano Corporation

Computation of Earnings to Fixed Charges Ratio

(Unauditedin thousands)



|                                                                              |      |                          |        |      |  |   |         |   |  |      |         |   |      |   |         |   |  |   |        |  
|----------------------------------------------------------------------------- | ---- | ------------------------ | ------ | ---- |  | - | ------- | - |  | ---- | ------- | - | ---- | - | ------- | - |  | - | ------ | -
|                                                                              |      | Years Ended December 31, |       
|                                                                              | 2010 |                          |        | 2009 |  |   | 2008    |   |  | 2007 |         |   | 2006 |  
|Earnings (loss)                                                               |      |                          |        |      |  |   |         |   |  |      |         |   |      |   |         |   |  |   |        |  
|Income (loss) before provision for income taxes                               |      | $                        | 7,327  |      |  | $ | (27,767 | ) |  | $    | (13,085 | ) |      | $ | (26,052 | ) |  | $ | (8,305 | )
|Fixed charges                                                                 |      |                          | 4,330  |      |  |   | 1,895   |   |  |      | 1,208   |   |      |   | 996     |   |  |   | 4,595  |  
|                                                                              |      |                          |        |      |  |   |         |   |  |      |         |   |      |   |         |   |  |   |        |  
|Total                                                                         |      |                          | 11,657 |      |  |   | (25,872 | ) |  |      | (11,877 | ) |      |   | (25,056 | ) |  |   | (3,710 | )
|                                                                              |      |                          |        |      |  |   |         |   |  |      |         |   |      |   |         |   |  |   |        |  
|Fixed Charges                                                                 |      |                          |        |      |  |   |         |   |  |      |         |   |      |   |         |   |  |   |        |  
|Interest expense on indebtedness and amortization of deferred financing costs |      | $                        | 2,192  |      |  | $ | 5       |   |  | $    | 113     |   |      | $ | 199     |   |  | $ | 4,013  |  
|Interest component of rentals (1)                                             |      |                          | 2,138  |      |  |   | 1,890   |   |  |      | 1,095   |   |      |   | 797     |   |  |   | 582    |  
|                                                                              |      |                          |        |      |  |   |         |   |  |      |         |   |      |   |         |   |  |   |        |  
|Total                                                                         |      | $                        | 4,330  |      |  | $ | 1,895   |   |  | $    | 1,208   |   |      | $ | 996     |   |  | $ | 4,595  |  
|                                                                              |      |                          |        |      |  |   |         |   |  |      |         |   |      |   |         |   |  |   |        |  
|Excess (deficiency of) earnings available to cover fixed charges              |      | $                        | 7,327  |      |  | $ | (27,767 | ) |  | $    | (13,085 | ) |      | $ | (26,052 | ) |  | $ | (8,305 | )
|                                                                              |      |                          |        |      |  |   |         |   |  |      |         |   |      |   |         |   |  |   |        |  

|(1) | Represents the estimated portion of operating lease rental expense that is considered by us to be representative of interest and amortization of discount related to
indebtedness.
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