Section
      A
      - Solicitation/Contract Form





GOVERNMENT
      CONTACTS


**Contract
      Specialist:**





U.S.
      Army
      Medical Research Acquisition Activity (USAMRAA


ATTM:
      MCMR-AAA-R (Mr. Jeff Ingram)


820
      Chandler Street


Fort
      Detrick, MD 21702-5014





Voice:  (301)
      619-1361


FAX:  (301)
      619-2505


Email:  jeff.ingram@us.army.mil








**Contracting
      Officer (KO)** (Authorized
      official to bind the Government in Contracts)





U.S.
      Army
      Medical Research Acquisition Activity (USAMRAA)


ATTM:
      MCMR-AAA (Ms. Pamela Nevels)


820
      Chandler Street


Fort
      Detrick, MD 21702-5014





Voice:  (301)
      619-8802


FAX:  (301)
      619-6662


Email:  pamela.nevels@amedd.army.mil








**Contracting
      Officer’s Representative (COR)** (Government
      customer/office receiving supplies/services)





USAMRICD


ATTN:
      MCMR-UV-CC (Dr John Graham)


3100 Ricketts Point Road


Aberdeen
      Proving Ground


MD,
      21010-5400


Voice:  (410)
      436-1197


Email:  John.Graham@amedd.army.mil





**RESEARCH
      TITLE** :
      Chemical Casualty Care: Wound Dressings Designed to Speed Wound Closure
      Following Debridement of Cutaneous Vesicant Injuries.





**TERM
      OF CONTRACT** :
      Phase I
      - November 14, 2005 - October 13, 2006 (Research ends May 13, 2005 for base
      period). The additional 5 months are to allow 1 month for submission of final
      report and 4 months to allow for Phase II determination. Phase II may or may
      not
      be awarded.





**TOTAL
      CONTRACT VALUE** :
      $70,000.00





**FUNDING
      PROVIDED TO DATE** :
      $70,000.00





**PROJECT
      MANAGER** :
      Dr.
      Bernd Liesenfeld





**CONTRACT
      TYPE** :
      Firm-Fixed Price





Section
      B
      - Supplies or Services and Prices














ITEM
                NO
            SUPPLIES/SERVICES
            QUANTITY
            UNIT
            UNIT
                PRICE
            AMOUNT0001Funds
                for SBIR Phase 1 awards
              FFP
              The
                contractor shall furnish the necessary equipment, personnel, facilities
                and supplies to conduct the SBIR Phase I research objectives in accordance
                with the Contract Schedule and the contractor's proposal No. A052-131-1765
                Topic A05-131, pages 12-16, wich are incorporated herin by reference.
                See
                Section G for payment instructions.
              PURCHASE
                REQUEST NUMBER: W81XWH-5291-M014NET
                AMT
            $0.00ACRN
                AB Funded Amount
            
            $70,000.00




FOB:
      Destination














ITEM
                NO
            SUPPLIES/SERVICES
            QUANTITY
            UNIT
            UNIT
                PRICE
            AMOUNT0001AA
            
            5
            Months
            $11,666.666
            $58,333.33Phase
                I Monthly Reports
              FFPNET
                AMT
            $58,333.33Funded
                Amount
            
            $0.00




FOB:
      Destination














ITEM
                NO
            SUPPLIES/SERVICES
            QUANTITY
            UNIT
            UNIT
                PRICE
            AMOUNT0001AB
            
            1
            Months
            $11,666.666
            $11,666.67Phase
                I Final Report
              FFPNET
                AMT
            $11,666.67Funded
                Amount
            
            $0.00




FOB:
      Destination














ITEM
                NO
            SUPPLIES/SERVICES
            QUANTITY
            UNIT
            UNIT
                PRICE
            AMOUNT0002
            
            4
            Months
            $10,000.00
            $40,000.00OPTION
            Phase
                I Option Period
              FFP
              The
                contractor shall furnish the necessary equipment, personnel, facilities
                and supplies to conduct the SBIR Phase I research objectives in accordance
                with the Contract Schedule and the contractor's proposal No. A052-131-1765
                Topic A05-131, pages 12-16, wich are incorporated herin by reference.
                See
                Section G for payment instructions.NET
                AMT
            $40,000.00Funded
                Amount
            
            $0.00




FOB:
      Destination














ITEM
                NO
            SUPPLIES/SERVICES
            QUANTITY
            UNIT
            UNIT
                PRICE
            AMOUNT0003
            
            
            
            
            NSPContractor
                Manpower Report (CMR)
              FFP
              Imput
                of the Accounting for Contract Services information in the web site
                operated and maintained by the Assistant Secretary of the Army (Manpower
                & Reserve Affairs). See the "Contractor Manpower Reporting" paragraph
                in Section C for specific reporting information. The Unit Identification
                Code for USAMRICD is: W4D7AANET
                AMTFunded
                Amount
            
            $0.00





FOB:
      Destination







Section
      C
      - Descriptions and Specifications


STATEMENT
      OF WORK


**1.
      STATEMENT OF WORK**





1.
      Background:





The
      U.S.
      Army Medical Research and Materiel Command, in support of the Department of
      Defense Small Business Innovation (SBIR) Program, has taken part in the Program
      Solicitation for FY2004. Objectives of the solicitation included stimulating
      technological innovation in the private sector, strengthening the role of the
      small business in meeting Federal research and development needs, fostering
      and
      encouraging participation by minority and disadvantaged persons in technological
      innovation, increasing the commercial application of DOD-supported research
      results, and improving their return on investment from Federally-funded research
      for economic and social benefits to the Nation. The Federal SBIR Program is
      mandated by Public Laws 97-219, 99-443, 102-564 and 106-554.





2.
      Phased
      Program:





a.
      Phase
      1 is to determine, insofar as possible, the scientific or technical merit and
      feasibility of ideas submitted under the SBIR program. The contractor shall
      concentrate on that research or development which will significantly contribute
      to providing the scientific or technical feasibility of the approach or concept
      and which would be a prerequisite to further DOD support in Phase
      II.





b.
      Phase
      II awards are expected to be made during Fiscal year 2005 to firms with
      approaches that appear sufficiently promising as a result of Phase I. Phase
      II
      awards are expected to typically cover 2 - 5 man-years of effort and to cover
      a
      period generally not to exceed 24 months, subject to negotiation. The number
      of
      Phase II awards will depend upon Phase I results and availability of funds.
      Phase II is the principal research or development effort; it will require a
      more
      comprehensive proposal, outlining the proposal effort.





c.
      Under
      Phase III, it is intended that non-Federal capital be used by the small business
      to pursue commercial applications of the research or development. Also, under
      Phase III, Federal agencies may award non-SBIR funded follow-on contracts for
      products or processes, which meet the mission needs of those
      agencies.





3.
      Contractor Manpower Reporting: Input of the Accounting for Contract services
      information in the web site operated and maintained by the Assistant Secretary
      of the Army (Manpower & Reserve Affairs) is required. See the “Contractor
      Manpower Reporting” paragraph in Section C below for specific reporting
      information.




CLAUSES
      INCORPORATED BY FULL TEXT




Contractor
      Manpower Reporting (CMR) - (Accounting for Contract Services)





The
      Office of the Assistant Secretary of the Army (Manpower & Reserve Affairs)
      operates and maintains a secure Army data collection site where the contractor
      will report ALL contractor manpower (including sub-contractor manpower) required
      for performance of this contract. The contractor is required to completely
      fill
      in all the information in the format using the following web address:
      https://contractormanpower.army.pentagon.mil. The required information includes:
      (l) Contracting Office, Contracting Officer, Contracting Officer's Technical
      Representative; (2) Contract number, including task and delivery order number;
      (3) Beginning and ending dates covered by reporting period; (4) Contractor
      name,
      address, phone number, e-mail address, identity of contractor employee entering
      data; (5) Estimated direct labor hours (including sub-contractors); (6)
      Estimated direct labor dollars paid this reporting period (including
      sub-contractors); (7) Total payments (including sub-contractors); (8)
      Predominant Federal Service Code (FSC) reflecting services provided by
      contractor (and separate predominant FSC for each sub-contractor if different);
      (9) Estimated data collection cost; (10) Organizational title associated with
      the Unit Identification Code (UIC) for the Army Requiring Activity (the Army
      Requiring Activity is responsible for providing the contractor with its UIC
      for
      the purposes of reporting this information); (ll) Locations where contractor
      and
      sub-contractors perform the work (specified by zip code in the United States
      and
      nearest city, country, when in an overseas location, using standardized
      nomenclature provided on website); (l2) Presence of deployment or contingency
      contract language; and (l3) Number of contractor and sub-contractor employees
      deployed in theater this reporting period (by country). As part of its
      submission, the contractor will also provide the estimated total cost (if any)
      incurred to comply with this reporting requirement. Reporting period will be
      the
      period of performance not to exceed 12 months ending 30 September of each
      government fiscal year and must be reported by 31 October of each calendar
      year.
      Contractors may use a direct XML data transfer to the database server or fill
      in
      the fields on the website. The XML direct transfer is a format for transferring
      files from a contractor's system to the secure web site without the need for
      separate data entries for each required data element at the web site. The
      specific formats for the XML direct transfer may be downloaded from the web
      site.




**Log
      number: 06287007**




**PRINCIPAL
      INVESTIGATOR (MAR 1999) (USAMRAA)**





The
      Principal Investigator for this contract is Bernd Liesenfeld. This individual
      shall be continuously responsible for the conduct of the research project.
      The
      contractor shall obtain the Contracting Officer's approval to change the
      Principal Investigator or to continue the research work during a continuous
      period in excess of three months without the participation of an approved
      Principal Investigator. This contract is based on the Principal Investigator
      devoting 360 of effort to the project over the term of the contract. The
      contractor shall advise the Contracting Officer if the Principal Investigator
      will, or plans to, devote substantially less effort to the work than estimated
      in the contractor's proposal. A curriculum vitae shall be provided for
      professional associates added to the research project or substituted during
      the
      course of work.




**INVESTIGATING
      AND REPORTING POSSIBLE SCIENTIFIC MISCONDUCT (MAR 1999)
      (USAMRAA)**





a.
      "Misconduct" or "Misconduct in Science" is defined as fabrication,
      falsification, plagiarism, or other practices that seriously deviate from those
      that are commonly accepted within the scientific community for proposing,
      conducting or reporting research. It does not include honest error or honest
      differences in interpretations or judgments of data.


b.
      Contractors shall foster a research environment that prevents misconduct in
      all
      research and that deals forthrightly with possible misconduct associated with
      research for which U.S. Army Medical Research and Materiel Command funds have
      been provided or requested.


c.
      The
      contractor agrees to:


(1)
      Establish and keep current an administrative process to review, investigate,
      and
      report allegations of misconduct in science in connection with research
      conducted by the contractor;


(2)
      Comply with its own administrative process;


(3)
      Inform its scientific and administrative staff of the policies and procedures
      and the importance of compliance with those policies and
      procedures;


(4)
      Take
      immediate and appropriate action as soon as misconduct on the part of employees
      or persons within the organization's control is suspected or alleged;
      and


(5)
      Report to the Administrative Contracting Officer (ACO)


a
      decision to initiate an investigation into possible scientific
      misconduct.


d.
      The
      contractor is responsible for notifying the ACO of appropriate action taken
      if
      at any stage of an inquiry or investigation any of the following conditions
      exist:


(1)
      An
      immediate health hazard is involved;


(2)
      There
      is an immediate need to protect Federal funds or equipment;


(3)
      A
      probability exists that the alleged incident will be reported publicly;
      or


(4)
      There
      is a reasonable indication of possible criminal violation.









**PROHIBITION
      OF USE OF HUMAN SUBJECTS (APR 2004) (USAMRAA)**





****** **PROHIBITION
      - READ FURTHER FOR DETAILS ****





Research
      under this award using human subjects may not begin until the U.S. Army Surgeon
      General's Human Subjects Research Review Board (HSRRB) approves the
      protocol. **** Written
      approval to begin research or subcontract for the use of human subjects under
      the applicable protocol proposed for this award will be issued from the US
      Army
      Medical Research and Materiel Command, HSRRB, under separate letter to the
      Contractor. A copy of this approval will be provided to the US Army Medical
      Research Acquisition Activity for the official file. Non-compliance with any
      provision of this clause may result in withholding of funds and or the
      termination of the award.



















**PROHIBITION
      OF USE OF LABORATORY ANIMALS (APR 2004) (USAMRAA)**





****** **PROHIBITION
      - READ FURTHER FOR DETAILS ****





Notwithstanding
      any other provisions contained in this award or incorporated by reference
      herein, the Contractor is expressly forbidden to use or subcontract for the
      use
      of laboratory animals in any manner whatsoever without the express written
      approval of the US Army Medical Research and Materiel Command, Animal Care
      and
      Use Office. The Contractor will receive written approval to begin research
      under
      the applicable protocol proposed for this award from the US Army Medical
      Research and Materiel Command, Animal Care and Use Office under separate letter.
      A copy of this approval will be provided to the US Army Medical Research and
      Acquisition Activity for the official file. Non-compliance with any provision
      of
      this clause may result in the termination of the award.




















**PROHIBITION
      OF USE OF HUMAN CADAVERS (APR 2004) (USAMRAA)**





****** **PROHIBITION
      - READ FURTHER FOR DETAILS****





Research
      under this award using human cadavers may not begin until the U.S. Army Surgeon
      General's Human Subjects Research Review Board (HSRRB) approves the
      protocol. **** Written
      approval to begin research or subcontract for the use of human cadavers under
      the applicable protocol proposed for this award will be issued from the US
      Army
      Medical Research and Materiel Command, HSRRB, under separate letter to the
      Contractor. A copy of this approval will be provided to the US Army Medical
      Research Acquisition Activity for the official file. Non-compliance with any
      provision of this clause may result in withholding of funds and or the
      termination of the award.
















**PROHIBITION
      OF USE OF HUMAN ANATOMICAL SUBSTANCES (APR 2004) (USAMRAA)**







****** **PROHIBITION
      - READ FURTHER FOR DETAILS****





Research
      under this award using human anatomical substances may not begin until the
      U.S.
      Army Surgeon General's Human Subjects Research Review Board (HSRRB) approves
      the
      protocol. **** Written
      approval to begin research or subcontract for the use of human anatomical
      substances under the applicable protocol proposed for this award will be issued
      from the US Army Medical Research and Materiel Command, HSRRB, under separate
      letter to the Contractor. A copy of this approval will be provided to the US
      Army Medical Research Acquisition Activity for the official file. Non-compliance
      with any provision of this clause may result in withholding of funds and or
      the
      termination of the award.











Section
      D
      - Packaging and Marking








a.
            Packing
                shall be standard Commercial to ensure acceptance by common carriers
                for
                safest delivery to destination unless otherwise specified in the
                specifications or descriptions of the
                items.


b.
            All
                shipping or mailing containers shall be marked showing Contract No.**W81XWH-06-C-0024**and the destination address shown in Section
                F.





Section
      E
      - Inspection and Acceptance














INSPECTION
      AND ACCEPTANCE TERMS





Supplies/services
      will be inspected/accepted at:





CLIN
            INSPECT
                AT
            INSPECT
                BY
            ACCEPT
                AT
            ACCEPT
                BY0001
            Destination
            Government
            Destination
            Government0001AA
            Destination
            Government
            Destination
            Government0001AB
            Destination
            Government
            Destination
            Government0002
            Destination
            Government
            Destination
            Government0003
            Destination
            Government
            Destination
            Government







CLAUSES
      INCORPORATED BY REFERENCE








52.246-9
            Inspection
                Of Research And Development (Short Form)
            APR
                1984





Section
      F
      - Deliveries or Performance





PERIOD
      OF PERFORMANCE


c.
            Phase
                I - November 14, 2005 - October 13, 2006 (Research ends May 13, 2005
                for
                base period). The additional 5 months are to allow 1 month for submission
                of final report and 4 months to allow for Phase II determination.
                Phase II
                may or may not be awarded.





d.
            The
                period of performance for Option Period I (CLIN 0002) is 14 June
                2006 - 13
                Oct. 2006 if exercised by the
                Government.




















DELIVERY
      INFORMATION





CLIN
            DELIVERY
                DATE
            QUANTITY
            SHIP
                TO ADDRESS
            UIC0001
            POP
                14-NOV-2005 TO
              13-OCT-2006
            N/A
            USA
                MED RESEARCH AND MATERIEL COM
              JUANITA
                LIVINGSTON
              504
                SCOTT STREET
              FORT
                DETRICK MD 21702-5012
              FOB:
                Destination
            W23RYX0001AA
            POP
                14-NOV-2005 TO
              13-OCT-2006
            N/A
            (SAME
                AS PREVIOUS LOCATION)
              FOB:
                Destination
            W23RYX0001AB
            POP
                14-NOV-2005 TO
              13-OCT-2006
            N/A
            (SAME
                AS PREVIOUS LOCATION)
              FOB:
                Destination
            W23RYX0002
            POP
                14-JUN-2006 TO
              13-OCT-2006
            N/A
            (SAME
                AS PREVIOUS LOCATION)
              FOB:
                Destination
            W23RYX0003
            POP
                14-NOV-2005 TO
              13-OCT-2006
            N/A
            (SAME
                AS PREVIOUS LOCATION)
              FOB:
                Destination
            W23RYX







CLAUSES
      INCORPORATED BY FULL TEXT













***FOR
      RESEARCH AND DEVELOPMENT CONTRACT AWARDS WITH******VARIOUS
      REPORTING REQUIREMENTS.***




***Fill
      in appropriate name and address of contract specialist and COR in monthly and
      quarterly reporting clauses. Areas are marked in "Red."***




***DELETE
      AND RENUMBER PARAGRAPHS (and, if applicable, quarterly report format), AS
      APPLICABLE. --- CHOOSE FROM THE FOLLOWING:***




***PARAGRAPH
      1. - MONTHLY TECHNICAL PROGRESS REPORTS - USED PREVIOUSLY FOR PHASE I SBIR
      AWARDS***




***PARAGRAPH
      2. - QUARTERLY REPORTS - USED PREVIOUSLY FOR PHASE II SBIR AWARDS (ensure that
      report format for quarterly reports, following quarterly report initial
      information, is included). The*** **Quarterly
      report should be modified to indicate (per instructions from the COR) if four
      (4) quarterly reports are required or if three (3) quarterly reports are
      required and then have the final report include the quarterly
      information**




**PARAGRAPH
      3 - ANNUAL AND FINAL REPORTS - USED PREVIOUSLY FOR ALL RESEARCH AND DEVELOPMENT
      CONTRACT AWARDS**




***FOR
      RESEARCH AND DEVELOPMENT CONTRACT AWARDS WITH*** ***VARIOUS
      REPORTING REQUIREMENTS.***




***Fill
      in appropriate name and address of contract specialist and COR in monthly and
      quarterly reporting clauses. Areas are marked in "Red."***




***DELETE
      AND RENUMBER PARAGRAPHS (and, if applicable, quarterly report format), AS
      APPLICABLE. --- CHOOSE FROM THE FOLLOWING:***




***PARAGRAPH
      1. - MONTHLY TECHNICAL PROGRESS REPORTS - USED PREVIOUSLY FOR PHASE I SBIR
      AWARDS***




***PARAGRAPH
      2. - QUARTERLY REPORTS - USED PREVIOUSLY FOR PHASE II SBIR AWARDS (ensure that
      report format for quarterly reports, following quarterly report initial
      information, is included). The*** **Quarterly
      report should be modified to indicate (per instructions from the COR) if four
      (4) quarterly reports are required or if three (3) quarterly reports are
      required and then have the final report include the quarterly
      information**




**PARAGRAPH
      3 - FORMAT REQUIREMENTS FOR ANNUAL AND FINAL REPORTS - USED PREVIOUSLY FOR
      ALL
      RESEARCH AND DEVELOPMENT CONTRACT AWARDS**




***FOR
      RESEARCH AND DEVELOPMENT CONTRACT AWARDS WITH*** ***VARIOUS
      REPORTING REQUIREMENTS.***




***Fill
      in appropriate name and address of contract specialist and COR in monthly and
      quarterly reporting clauses. Areas are marked in "Red."***




***DELETE
      AND RENUMBER PARAGRAPHS (and, if applicable, quarterly report format), AS
      APPLICABLE. --- CHOOSE FROM THE FOLLOWING:***




***PARAGRAPH
      1. - MONTHLY TECHNICAL PROGRESS REPORTS - USED PREVIOUSLY FOR PHASE I SBIR
      AWARDS***




***PARAGRAPH
      2. - QUARTERLY REPORTS - USED PREVIOUSLY FOR PHASE II SBIR AWARDS (ensure that
      report format for quarterly reports, following quarterly report initial
      information, is included). The*** **Quarterly
      report should be modified to indicate (per instructions from the COR) if four
      (4) quarterly reports are required or if three (3) quarterly reports are
      required and then have the final report include the quarterly
      information**




**PARAGRAPH
      3 - ANNUAL AND FINAL REPORTS - USED PREVIOUSLY FOR ALL RESEARCH AND DEVELOPMENT
      CONTRACT AWARDS**




**REPORTING
      REQUIREMENTS (MARCH 2005) (USAMRAA)**







**1.** **MONTHLY
      TECHNICAL PROGRESS REPORTS**





**** a **.**  The
      contractor shall submit a Monthly Technical Progress Report covering work
      accomplished during each calendar month of contract performance. It shall be
      brief, factual, and informal, and shall be prepared in accordance with the
      following:




(1)
      Cover
      containing:





(a)
      Contract number and title





(b)
      Type
      of report, sequence number of report, and period of performance being
      reported





(c)
      Contractor's name, address, and telephone number





(d)
      Principal Investigator





(e)
      Date
      of publication





(f)
      Contracting Officer's Representative





(2)
      Section I - A brief introduction covering the purpose and scope of the research
      effort.





(3)
      Section II - A brief description of overall progress to date plus a separate
      description for each task or other logical segment of work on which effort
      was
      expended during the report period. Description shall include pertinent data
      and
      graphs in sufficient detail to explain any significant results
      achieved.





(4)
      Section III - Problem Areas





(a)
      A
      description of current problems that may impede performance along with proposed
      corrective action.





(b)
      A
      description of anticipated problems that have a potential to impede progress
      and
      what corrective action is planned should the problem materialize.





(5)
      Section IV - A description of work to be performed during the next reporting
      period.





(6)
      Section V - Administrative Comments (Optional) - Description of proposed site
      visits and participation in technical meetings, journal manuscripts in
      preparation, coordination with other organizations conducting related work,
      etc.





(7)
      Section VI - A Gantt Chart showing actual progress versus scheduled
      progress.





b.  Monthly
      Technical Progress Reports shall be prepared by the seventh day following the
      month being reported, and shall be received within 10 days of the report month.
      The Monthly Technical Progress Report shall be submitted to the following
      addresses:





One
      Copy:  Director


U.S.
      Army
      Medical Research Acquisition Activity (USAMRAA)


ATTN:
      MCMR-AAA -B


820
      Chandler Street


Fort
      Detrick, MD 21702-5014




One Copy:   USAMRICD


ATTN:
      John Graham


Building
      E3081 Room 231


3100
      Ricketts Point Rd.


Aberdeen
      Proving Ground, MD 21010-5400


Voice:
      (401)-436-1197


Email:
      John.s.graham1@us.army.mil








**2.** **QUARTERLY
      REPORTS** **(Reserved)**











**3.
      FORMAT REQUIREMENTS FOR ANNUAL/FINAL REPORTS**





**** a.
      Reserved




b.
      A
      final report summarizing the entire research effort, citing data in the annual
      reports and appended publications shall be submitted at the end of the award
      performance period. The final report will provide a complete reporting of the
      research findings. Journal publications **can
      be** substituted for detailed descriptions of specific aspects of the research,
      but
      an original copy of each publication **must** be
      attached as an appendix and appropriately referenced in the text. All final
      reports must include a bibliography of all publications and meeting abstracts
      and a list of personnel (not salaries) receiving pay from the research effort.






c.
      Although there is no page limitation for the reports, each report shall be
      of
      sufficient length to provide a thorough description of the accomplishments
      with
      respect to the approved Statement of Work. Submission of the report in
      electronic format (PDF or Word file only) shall be submitted to https://ers.detrick.army.mil .






All
      reports **shall** have the
      following elements, in this order:




**FRONT
      COVER** :
      A
      Sample front cover is provided at https://mrmc.detrick.army.mil/rrpindex.asp .
      The
      Accession Document (AD) Number should remain blank.





**STANDARD
      FORM 298** :
      A
      Sample SF 298 is provided at https://mrmc.detrick.army.mil/rrpindex.asp .
      The
      abstract in Block 13 must state the purpose, scope, major findings and be an
      up-to-date report of the progress in terms of results and significance. Subject
      terms are keywords that may have previously assigned to the proposal abstract
      or
      are keywords that may be significant to the research. The number of pages shall
      include all pages that have printed data (including the front cover, SF 298,
      table of contents, and all appendices). Please count pages carefully to ensure
      legibility and that there are no missing pages as this delays processing of
      reports. Page numbers should be typed: please do not hand number
      pages.





**TABLE
      OF CONTENTS** :
      Sample
      table of contents provided at https://mrmc.detrick.army.mil/rrpindex.asp .





**INTRODUCTION** :
      Narrative that briefly (one paragraph) describes the subject, purpose and scope
      of the research.





**BODY** :
      This
      section of the report shall describe the research accomplishments associated
      with each task outlined in the approved Statement of Work. Data presentation
      shall be comprehensive in providing a complete record of the research findings
      for the period of the report. Provide data explaining the relationship of the
      most recent findings with that of previously reported findings. Appended
      publications and/or presentations may be substituted for detailed descriptions
      of methodology but must be referenced in the body of the report. If applicable,
      for each task outlined in the Statement of Work, reference appended publications
      and/or presentations for details of result findings and tables and/or figures.
      The report shall include negative as well as positive findings. Include problems
      in accomplishing any of the tasks. Statistical tests of significance shall
      be
      applied to all data whenever possible. Figures and graphs referenced in the
      text
      may be embedded in the text or appended. Figures and graphs can also be
      referenced in the text and appended to a publication. Recommended changes or
      future work to better address the research topic may also be included, although
      changes to the original Statement of Work must be approved by the Army
      Contracting Officer's Representative. This approval must be obtained prior
      to
      initiating any change to the original Statement of Work.





**KEY
      RESEARCH ACCOMPLISHMENTS** :
      Bulleted list of key research accomplishments emanating from this
      research.





**REPORTABLE
      OUTCOMES** :
      Provide
      a list of reportable outcomes that have resulted from this research to
      include:





manuscripts,
      abstracts, presentations; patents


and
      licenses applied for and/or issued; degrees


obtained
      that are supported by this award;


development
      of cell lines, tissue or serum


repositories;
      infomatics such as databases and


animal
      models, etc.; funding applied for based


on
      work
      supported by this award; employment


or
      research opportunities applied for and/or


received
      based on experience/training supported


by
      this
      award.





**CONCLUSION** :
      Summarize the results to include the importance and/or implications of the
      completed research and when necessary, recommend changes on future work to
      better address the problem. A "so what section" which evaluates the knowledge
      as
      a scientific or medical product shall also be included in the conclusion of
      the
      report.





**REFERENCES** :
      List
      all references pertinent to the report using a standard journal format (i.e.
      format used in *Science,
      Military Medicine* ,
      etc.).





**APPENDICES** :
      Attach
      all appendices that contain information that supplements, clarifies or supports
      the text. Examples include original copies of journal articles, reprints of
      manuscripts and abstracts, a curriculum vitae, patent applications, study
      questionnaires, and surveys, etc.





Pages
      shall be consecutively numbered throughout the report. DO
      NOT
      RENUMBER PAGES IN THE APPENDICES.





Mark
      all
      pages of the report which contain proprietary or unpublished data that should
      be
      protected by the U.S. Government. REPORTS
      NOT PROPERLY MARKED FOR LIMITATION WILL BE DISTRIBUTED AS APPROVED FOR PUBLIC
      RELEASE .
      It is
      the responsibility of the Principal Investigator to advise the U.S. Army Medical
      Research and Materiel Command when restricted limitation assigned to a document
      can be downgraded to Approved for Public Release. DO
      NOT
      USE THE WORD "CONFIDENTIAL" WHEN MARKING DOCUMENTS .









**REPORTS,
      MANUSCRIPTS AND PUBLIC RELEASES (APR 2004) (USAMRAA)**





a.
      Contractors are encouraged to publish results of research supported by the
      US
      Army Medical Research and Materiel Command (USAMRMC) in appropriate media forum.
      Any publication, report or public release, which may create a statutory bar
      to
      the issuance of a patent on any subject invention, shall be coordinated with
      appropriate patent counsel.





b.
      Manuscripts intended for publication in any media shall be submitted to the
      Contracting Officer and Contracting Officer's Representative (COR),
      simultaneously with submission for publication. Review of such manuscripts
      is
      for comment to the Principal Investigator, not for approval or disapproval.
      Courtesy copies of the reprint shall be forwarded to the Contracting Officer
      and
      COR, even though publication may be subsequent to the expiration of the
      contract.





c.
      The
      Contractor shall notify the Contracting Officer of planned news releases,
      planned publicity, advertising material concerning contract work, and planned
      presentations to scientific meetings, prior to public release. This is not
      intended to restrict dissemination of research information but to allow USAMRMC
      advance notice in order to adequately respond to inquiries.





d.
      Manuscripts, reports, public releases and abstracts, which appear in
      professional journals, media and programs, shall include the following
      statements:





(l)
      "This
      work is supported by the US Army Medical Research and Materiel Command under
      Contract No. W81XWH-06-C-0024."





(2)
      "The
      views, opinions and/or findings contained in this report are those of the
      author(s) and should not be construed as an official Department of the Army
      position, policy or decision unless so designated by other documentation."





(3)
      As
      applicable, if the research involves the use of animals, the Contractor must
      include the following statement: "In conducting research using animals, the
      investigator(s) adhered to the Animal Welfare Act Regulations and other Federal
      statutes relating to animals and experiments involving animals and the
      principles set forth in the Guide for Care and Use of Laboratory Animals,
      National Research Council, 1996."





(4)
      As
      applicable, if the research involves human use, the Contractor must include
      the
      following statement: "In the conduct of research where humans are the subjects,
      the investigator(s) adhered to the policies regarding the protection of human
      subjects as prescribed by Code of Federal Regulations (CFR) Title 45, Volume
      1,
      Part 46; Title 32, Chapter 1, Part 219; and Title 21, Chapter 1, Part 50
      (Protection of Human Subjects)."





(5)
      As
      applicable, if the research involves the use of recombinant DNA, the Contractor
      must include the following statement: "In conducting work involving the use
      of
      recombinant DNA the investigator(s) adhered to the National Institutes of Health
      (NIH) Guidelines for Research Involving Recombinant DNA Molecules; Notice,
      Federal Register, November 19, 2001, Volume 66, Number 223."







Section
      G
      - Contract Administration Data














ACCOUNTING
      AND APPROPRIATION DATA





AB:
            2152040000006N6N7A6655002M400255Y5P66SBMIPR5A6NR4D5666SB5P011071AMOUNT:
            $70,000.00

















ACCOUNTING
      AND APPROPRIATION DATA





AB:
            2152040000006N6N7A6655002M400255Y5P66SBMIPR5A6NR4D5666SB5P011071AMOUNT:
            $70,000.00







CLAUSES
      INCORPORATED BY FULL TEXT








**REPRESENTATIONS
      AND CERTIFICATIONS (MAR 1999) (USAMRAA)**





The
      representations, certifications, and other statements submitted by the
      contractor, dated 14 October 2005, are incorporated herein by
      reference.











**USE
      OF TECHNICAL REFERENCE FACILITY (APR 2005) (USAMRAA)**





The
      contractor agrees to use **,** to
      the
      extent practical **,** the
      technical reference facilities of the Defense Technical Information Center
      (DTIC) for the purpose of surveying existing knowledge and avoiding needless
      duplication of scientific and engineering effort and the expenditure thereby
      represented. The DTIC headquarters office is located at 8725 John J. Kingman
      Road, Fort Belvoir, VA 22060-6218. Information can also be obtained via the
      Internet at http://www.dtic.mil or via the toll-free number for the DTIC help
      desk, 1-800-225-3842. To the extent practical, all other sources, whether or
      not
      Government controlled, should be consulted for the same purpose.














TRAVEL
      (JULY 2005) (USAMRAA)





a.
      Approval of Foreign Travel. The cost of foreign travel is allowable only when
      the specific written approval of the Contracting Officer is obtained prior
      to
      commencing the trip. Approval shall be requested at least 30 calendar
      days before the scheduled departure date in order that all necessary clearances
      may be processed. Each individual trip must be approved separately, even though
      it may have been included in a previously approved budget. Foreign travel under
      this contract is defined as any travel outside of the United States and its
      territories and possessions.





b.
      Costs
      incurred by contractor personnel on official company business, whether foreign
      travel and/or domestic/local travel, are allowable, subject to the limitations
      contained in the Federal Acquisition Regulation (FAR) clause at 52.216-7,
      Allowable Cost and Payment, incorporated into this contract by reference, and
      FAR Part 31.2.




















**PROPERTY
      REPORTING (COMMERCIAL) (MAR 1999) (USAMRAA)**





The
      designated property administrator for Government property acquired for use
      under
      this contract is the Contract Specialist, US Army Medical Research Acquisition
      Activity, Fort Detrick, MD 21702-5014. The contractor shall furnish the
      designated property administrator report, (i.e. DD FORM 1662, DOD Property
      in
      the Custody of Contractors).


a.
      Interim Inventories - Annually, as of 30 September, report due 10 October,
      each
      year.


b.
      Final
      Inventory - When the contract expires.








Section
      I
      - Contract Clauses





CLAUSES
      INCORPORATED BY REFERENCE








52.202-1
            Definitions
            JUL
                200452.203-3
            Gratuities
            APR
                198452.203-5
            Covenant
                Against Contingent Fees
            APR
                198452.203-6
            Restrictions
                On Subcontractor Sales To The Government
            JUL
                199552.203-7
            Anti-Kickback
                Procedures
            JUL
                199552.203-8
            Cancellation,
                Rescission, and Recovery of Funds for Illegal or Improper Activity
            JAN
                199752.203-10
            Price
                Or Fee Adjustment For Illegal Or Improper Activity
            JAN
                199752.203-12
            Limitation
                On Payments To Influence Certain Federal Transactions
            SEP
                200552.204-4
            Printed
                or Copied Double-Sided on Recycled Paper
            AUG
                200052.209-6
            Protecting
                the Government's Interest When Subcontracting With Contractors Debarred,
                Suspended, or Proposed for Debarment
            JAN
                200552.215-2
            Audit
                and Records--Negotiation
            JUN
                199952.215-8
            Order
                of Precedence--Uniform Contract Format
            OCT
                199752.215-10
            Price
                Reduction for Defective Cost or Pricing Data
            OCT
                199752.215-18
            Reversion
                or Adjustment of Plans for Postretirement Benefits (PRB) Other than
                Pensions
            JUL
                200552.215-21
            Requirements
                for Cost or Pricing Data or Information Other Than Cost or Pricing
                Data--Modifications
            OCT
                199752.219-8
            Utilization
                of Small Business Concerns
            MAY
                200452.219-14
            Limitations
                On Subcontracting
            DEC
                199652.222-3
            Convict
                Labor
            JUN
                200352.222-21
            Prohibition
                Of Segregated Facilities
            FEB
                199952.222-26
            Equal
                Opportunity
            APR
                200252.222-35
            Equal
                Opportunity For Special Disabled Veterans, Veterans of the Vietnam
                Era,
                and Other Eligible Veterans
            DEC
                200152.222-36
            Affirmative
                Action For Workers With Disabilities
            JUN
                199852.222-37
            Employment
                Reports On Special Disabled Veterans, Veterans Of The Vietnam Era,
                and
                Other Eligible Veterans
            DEC
                200152.223-14
            Toxic
                Chemical Release Reporting
            AUG
                200352.225-13
            Restrictions
                on Certain Foreign Purchases
            MAR
                200552.225-16
            Sanctioned
                European Union Country Services
            FEB
                200052.226-1
            Utilization
                Of Indian Organizations And Indian-Owned Economic Enterprises
            JUN
                200052.227-1
                Alt I
            Authorization
                And Consent (Jul 1995) - Alternate I
            APR
                198452.227-2
            Notice
                And Assistance Regarding Patent And Copyright Infringement
            AUG
                199652.227-11
            Patent
                Rights--Retention By The Contractor (Short Form)
            JUN
                199752.227-20
            Rights
                in Data - SBIR Program
            MAR
                199452.229-3
            Federal,
                State And Local Taxes
            APR
                200352.232-1
            Payments
            APR
                198452.232-2
            Payments
                Under Fixed-Price Research And Development Contracts
            APR
                198452.232-9
            Limitation
                On Withholding Of Payments
            APR
                198452.232-23
                Alt I
            Assignment
                of Claims (Jan 1986) - Alternate I
            APR
                198452.232-25
            Prompt
                Payment
            OCT
                200352.233-1
            Disputes
            JUL
                200252.233-3
            Protest
                After Award
            AUG
                199652.242-13
            Bankruptcy
            JUL
                199552.243-1
                Alt V
            Changes--Fixed-Price
                (Aug 1987) - Alternate V
            APR
                198452.244-5
            Competition
                In Subcontracting
            DEC
                199652.244-6
            Subcontracts
                for Commercial Items
            DEC
                200452.249-1
            Termination
                For Convenience Of The Government (Fixed Price) (Short Form)
            APR
                198452.249-2
            Termination
                For Convenience Of The Government (Fixed-Price)
            MAY
                200452.249-9
            Default
                (Fixed-Priced Research And Development)
            APR
                198452.253-1
            Computer
                Generated Forms
            JAN
                1991252.201-7000
            Contracting
                Officer's Representative
            DEC
                1991252.203-7001
            Prohibition
                On Persons Convicted of Fraud or Other Defense-Contract-Related Felonies
            DEC
                2004252.204-7000
            Disclosure
                Of Information
            DEC
                1991252.204-7003
            Control
                Of Government Personnel Work Product
            APR
                1992252.205-7000
            Provision
                Of Information To Cooperative Agreement Holders
            DEC
                1991252.209-7004
            Subcontracting
                With Firms That Are Owned or Controlled By The Government of a Terrorist
                Country
            MAR
                1998252.225-7001
            Buy
                American Act And Balance Of Payments Program
            JUN
                2005252.225-7002
            Qualifying
                Country Sources As Subcontractors
            APR
                2003252.225-7012
            Preference
                For Certain Domestic Commodities
            JUN
                2004252.227-7015
            Technical
                Data--Commercial Items
            NOV
                1995252.227-7016
            Rights
                in Bid or Proposal Information
            JUN
                1995252.227-7018
            Rights
                in Noncommercial Technical Data and Computer Software--Small Business
                Innovation Research (SBIR) Program
            JUN
                1995252.227-7019
            Validation
                of Asserted Restrictions--Computer Software
            JUN
                1995252.227-7025
            Limitations
                on the Use or Disclosure of Government-Furnished Information Marked
                with
                Restrictive Legends
            JUN
                1995252.227-7027
            Deferred
                Ordering Of Technical Data Or Computer Software
            APR
                1988252.227-7030
            Technical
                Data--Withholding Of Payment
            MAR
                2000252.227-7034
            Patents--Subcontracts
            APR
                1984252.227-7037
            Validation
                of Restrictive Markings on Technical Data
            SEP
                1999252.227-7039
            Patents--Reporting
                Of Subject Inventions
            APR
                1990252.231-7000
            Supplemental
                Cost Principles
            DEC
                1991252.232-7003
            Electronic
                Submission of Payment Requests
            JAN
                2004252.235-7010
            Acknowledgment
                of Support and Disclaimer
            MAY
                1995252.235-7011
            Final
                Scientific or Technical Report
            NOV
                2004252.243-7001
            Pricing
                Of Contract Modifications
            DEC
                1991252.247-7023
            Transportation
                of Supplies by Sea
            MAY
                2002252.247-7024
            Notification
                Of Transportation Of Supplies By Sea
            MAR
                2000







CLAUSES
      INCORPORATED BY FULL TEXT








EXPORT
      CONTRACT ACT COMPLIANCE





The
      contractor shall assess the work to be performed in this effort to assure that
      all actions are in compliance with the Export Administration Regulations, 15
      CFR
      Part 730 (EAR), of the Export Administration Act of 1979, 50 U.S.C. app.
      2401-2420 (EAA). Technology listed in the Commerce Control List (CCL), 15 CFR
      Part 774, of the EAR shall not be exported or exposed to foreign nationals
      without the written consent of the U.S. Department of Commerce.











52.217-9
      OPTION TO EXTEND THE TERM OF THE CONTRACT (MAR 2000)





(a)
      The
      Government may extend the term of this contract by written notice to the
      Contractor within 7 days; provided that the Government gives the Contractor
      a
      preliminary written notice of its intent to extend at least 30 days before
      the
      contract expires. The preliminary notice does not commit the Government to
      an
      extension.





(b)
      If
      the Government exercises this option, the extended contract shall be considered
      to include this option clause.





(c)
      The
      total duration of this contract, including the exercise of any options under
      this clause, shall not exceed 3
      years .














52.252-2
      CLAUSES INCORPORATED BY REFERENCE (FEB 1998)





This
      contract incorporates one or more clauses by reference, with the same force
      and
      effect as if they were given in full text. Upon request, the Contracting Officer
      will make their full text available. Also, the full text of a clause may be
      accessed electronically at this/these address(es):





www.usamraa.army.mil