# Patent

## Title
Bifunctional phenyl ISO (THIO) cyanates, processes and intermediates for their preparation

## Abstract

A process for preparing phenyl iso(thio)cyanates of the formula I in which a compound of the formula II or its HCl adduct is reacted with a phosgenating agent




where W is oxygen or sulfur and Ar and A are as defined in claim 1 is described.

Moreover, the invention relates to the use of the phenyl iso(thio)cyanates for preparing crop protection agents.

## Background
CROSS REFERENCE TO RELATED APPLICATION
This application is a divisional of U.S. application Ser. No. 10/532,931, filed Apr. 28, 2005, which is a 35 USC §371 National Phase Entry Application from PCT/EP03/012013, filed Oct. 29, 2003, and designating the United States, the disclosure of which is incorporated herein in its entirety by reference.


The invention relates to a process for preparing bifunctional phenyl iso(thio)cyanates of the formula I having an acylsulfonamide group




where the variables are as defined below:

    W is oxygen or sulfur,
    Ar is phenyl which may be mono- or polysubstituted by the following groups: hydrogen, halogen, C1-C4-haloalkyl or cyano,
    A is a radical derived from a primary or secondary amine or is NH2,

by reacting anilines or their hydrochlorides with phosgene derivatives. The invention also relates to bifunctional phenyl iso(thio)cyanates.



Iso(thio)cyanatobenzoylsulfamic acid amides are potential precursors for the preparation of crop protection agents having a triazole-3,5-dion-4-yl group, pyrimidine-2,6-dion-1-yl group or 1,3,5-triazine-2,4,6-trion-1-yl group or their S analogs as described, for example, in WO 01/83459. Owing to their reactivity, it should be easy to convert the iso(thio)cyanato structural unit into other groups such as (thio)urea or urethane groups. However, for the reasons mentioned below, their preparation was thought to be impossible.
In principle, phenyl iso(thio)cyanates can be prepared by reacting primary aromatic amines with phosgene and thiophosgene, respectively (see, for example, Houben-Weyl, Methoden der organischen Chemie [methods of organic chemistry], 4th edition, Vol. IX, pp. 869, 875-877 and Vol. VIII, pp. 120-124). Further general processes are known, for example, from EP 70389, EP 75267 and EP 409 025.
Common to all of the processes described is that the phenyl iso(thio)cyanates used do not carry an acylsulfonamide group. This is because it is known that an iso(thio)cyanato group can react with a sulfonamide group with formation of sulfonylureas. Thus, for example, J. Cervello and T. Sastre describe, in Synthesis 1990, 221-222, the reaction of a sulfonamide with isocyanates according to the equation below:




U.S. Pat. No. 4,309,209 discloses that phenyl isocyanates react with chloromethane-(N-methyl)sulfonamide (=ClCH2SO2NHCH3) with formation of a 1,2,4-thiadiazolidine-1,1,3-trione. P. Schwenkkraus and H.-H. Otto describe, in Arch. Pharm. (Weinheim), 326 (1993), 437-441, the reaction of 3-haloalkyl-β-sultames with phenyl isocyanate with formation of carbamoyl compounds.
DE 3433391 discloses the reaction of saccharin with acyl isocyanates to give N-acylated saccharin derivatives.
In JZV Akad Nauk SSSR, Ser Khim 1990, 2874 (English translation: Bulletin of the Academy of Sciences of the USSR, Division of Chemical Sciences, Vol. 39, (1990), p. 2610), B. A. Arbuzov, N. N. Zobova and N. R. Fedotava describe the N- and O-acylation of saccharin by reaction with a trifluoroacetyl isocyanate.
Against this background, both the preparation of phenyl iso(thio)cyanates which, in the same molecule, also carry a reactive acylsulfonamide function and their isolation—without subsequent intermolecular reactions—have been thought to be impossible. A person skilled in the art would have assumed that, owing to their acidic proton, sulfonamides would react with phenyl iso(thio)cyanates to give sulfonylurea derivatives. Hitherto, no process for the preparation of phenyl iso(thio)cyanates which, as further functional group, carry an acylsulfonamide group has been described.
It is an object of the present invention to provide iso(thio)cyanatobenzoylsulfamic acid amides of the formula I. We have found that this object is achieved, surprisingly, by a process in which an aminobenzoylsulfamic acid amide of the formula II




where the variables Ar and A are as defined above is reacted with phosgene, diphosgene or thiophosgene.

Accordingly, the present invention relates to a process for preparing phenyl iso(thio)cyanates of the formula I which comprises reacting a compound of the formula II or its HCl adduct with phosgene, thiophosgene or diphosgene (see Scheme 1). In Scheme 1, the variables Ar, A and W are as defined above.




The phenyl iso(thio)cyanates I obtainable in high yield by the process according to the invention are useful intermediates for the preparation of crop protection agents, in particular of 3-(triazolidinone)-substituted phenylsulfamoylcarboxamides. Accordingly, the present invention also provides a process for preparing 3-heterocyclyl-substituted phenylsulfamoylcarboxamides starting with phenyl iso(thio)cyanates I. Contrary to expectation, the compounds I according to the invention are stable compounds which are readily prepared, even on an industrial scale. Accordingly, the invention also relates to the phenyl iso(thio)cyanates of the formula I. The stability of the compounds I according to the invention is surprising, since a person skilled in the art would have expected an intermolecular reaction between the iso(thio)cyanato structural unit and the sulfamide grouping to take place.
The organic molecular moieties mentioned in the definition of the substituents are—like the term halogen—collective terms for individual enumerations of the individual group members, where the term Cn-Cm indicates the possible number of carbon atoms in the molecular moiety. All carbon chains, i.e. all alkyl, alkenyl and alkynyl moieties, may be straight-chain or branched. Unless indicated otherwise, halogenated substituents preferably carry one to six identical or different halogen atoms. In each case, the term “halogen” denotes fluorine, chlorine, bromine or iodine.
Examples of other meanings are:

    
    
        C1-C4-alkyl: for example methyl, ethyl, propyl, 1-methylethyl, butyl, 1-methylpropyl, 2-methylpropyl or 1,1-dimethylethyl;
        C1-C10-alkyl: a saturated aliphatic hydrocarbon radical having 1 to 10 carbon atoms, for example C1-C4-alkyl as mentioned above, and also, for example, n-pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, 1-ethylpropyl, hexyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2-trimethylpropyl, 1-ethyl-1-methylpropyl, 1-ethyl-3-methylpropyl, n-heptyl, n-nonyl, n-decyl, 1-methylhexyl, 1-ethylhexyl, 1-methylheptyl, 1-methyloctyl, 1-methylnonyl;
        C2-C10-alkenyl: a monounsaturated olefinic hydrocarbon radical having 2 to 10 carbon atoms, preferably 3 to 6 carbon atoms, for example ethenyl, prop-2-en-1-yl (=allyl), prop-1-en-1-yl, but-1-en-4-yl, but-2-en-1-yl, but-3-en-1-yl, 1-methylprop-2-en-1-yl, 2-methylprop-2-en-1-yl, 1-penten-3-yl, 1-penten-4-yl, 2-penten-4-yl, 1-methylbut-2-en-1-yl, 2-methylbut-2-en-1-yl, 3-methylbut-2-en-1-yl, 1-methylbut-3-en-1-yl, 2-methylbut-3-en-1-yl, 3-methylbut-3-en-1-yl, 1,1-dimethylprop-2-en-1-yl, 1,2-dimethylprop-2-en-1-yl, 1-ethylprop-2-en-1-yl, 1-ethylprop-1-en-2-yl, n-hex-1-en-1-yl, n-hex-2-en-1-yl, hex-3-en-1-yl, hex-4-en-1-yl, hex-5-en-1-yl, 1-methylpent-1-en-1-yl, 2-methylpent-1-en-1-yl, 3-methylpent-1-en-1-yl, 4-methylpent-1-en-1-yl, 1-methylpent-2-en-1-yl, 2-methylpent-2-en-1-yl, 3-methylpent-2-en-1-yl, 4-methylpent-2-en-1-yl, 1-methylpent-3-en-1-yl, 2-methylpent-3-en-1-yl, 3-methylpent-3-en-1-yl, 4-methylpent-3-en-1-yl, 1-methylpent-4-en-1-yl, 2-methylpent-4-en-1-yl, 3-methylpent-4-en-1-yl, 4-methylpent-4-en-1-yl, 1,1-dimethylbut-2-en-1-yl, 1,1-dimethylbut-3-en-1-yl, 1,2-dimethylbut-2-en-1-yl, 1,2-dimethylbut-3-en-1-yl, 1,3-dimethylbut-2-en-1-yl, 1,3-dimethylbut-3-en-1-yl, 2,2-dimethylbut-3-en-1-yl, 2,3-dimethylbut-2-en-1-yl, 2,3-dimethylbut-3-en-1-yl, 3,3-dimethylbut-2-en-1-yl, 1-ethylbut-2-en-1-yl, 1-ethylbut-3-en-1-yl, 2-ethylbut-2-en-1-yl, 2-ethylbut-3-en-1-yl, 1,1,2-trimethylprop-2-en-1-yl, 1-ethyl-1-methylprop-2-en-1-yl, 1-ethyl-2-methylprop-2-en-1-yl, hept-2-en-1-yl, oct-2-en-1-yl, non-2-en-1-yl, dec-2-en-1-yl;
        C2-C10-alkynyl: a hydrocarbon radical having 2 to 10 carbon atoms, preferably 3 to 6 carbon atoms, and one triple bond, for example ethynyl, prop-2-yn-1-yl (=propargyl), prop-1-yn-1-yl, but-1-yn-1-yl, but-1-yn-3-yl, but-1-yn-4-yl, but-2-yn-1-yl, pent-1-yn-1-yl, pent-1-yn-3-yl, pent-1-yn-4-yl, pent-1-yn-5-yl, pent-2-yn-1-yl, pent-2-yn-4-yl, pent-2-yn-5-yl, 3-methylbut-1-yn-3-yl, 3-methylbut-1-yn-4-yl, hex-1-yn-3-yl, hex-1-yn-4-yl, hex-1-yn-5-yl, hex-1-yn-6-yl, hex-2-yn-1-yl, hex-2-yn-4-yl, hex-2-yn-5-yl, hex-2-yn-6-yl, hex-3-yn-1-yl, hex-3-yn-2-yl, 3-methylpent-1-yn-3-yl, 3-methylpent-1-yn-4-yl, 3-methylpent-1-yn-5-yl, 4-methylpent-2-yn-4-yl, 4-methylpent-2-yn-5-yl, hept-2-yn-1-yl, Oct-2-yn-1-yl, non-2-yn-1-yl, dec-2-yn-1-yl;
        C1-C4-haloalkyl: a C1-C4-alkyl radical as mentioned above which is partially or fully substituted by fluorine, chlorine, bromine and/or iodine, i.e., for example, chloromethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlorofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl, 2-fluoroethyl, 2-chloroethyl, 2-bromoethyl, 2-iodoethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro-2,2-difluoroethyl, 2,2-dichloro-2-fluoroethyl, 2,2,2-trichloroethyl, pentafluoroethyl, 2-fluoropropyl, 3-fluoropropyl, 2,2-difluoropropyl, 2,3-difluoropropyl, 2-chloropropyl, 3-chloropropyl, 2,3-dichloropropyl, 2-bromopropyl, 3-bromopropyl, 3,3,3-trifluoropropyl, 3,3,3-trichloropropyl, 2,2,3,3,3-pentafluoropropyl, heptafluoropropyl, 1-(fluoromethyl)-2-fluoroethyl, 1-(chloromethyl)-2-chloroethyl, 1-(bromomethyl)-2-bromoethyl, 4-fluorobutyl, 4-chlorobutyl, 4-bromobutyl or nonafluorobutyl;
        C1-C10-haloalkyl: C1-C10-alkyl as mentioned above in which 1 to 6 hydrogen atoms are substituted by halogen atoms, preferably by fluorine and/or chlorine, for example: C1-C4-haloalkyl as mentioned above, and also 5-fluoropentyl, 5-chloropentyl, 5-bromopentyl, 5-iodopentyl, undecafluoropentyl, 6-fluorohexyl, 6-chlorohexyl, 6-bromohexyl or 6-iodohexyl;
        C2-C10-haloalkenyl: C2-C10-alkenyl as mentioned above in which 1 to 6 hydrogen atoms are substituted by halogen atoms, preferably by fluorine and/or chlorine: for example 2-chloroallyl, 3-chloroallyl, 2,3-dichloroallyl, 3,3-dichloroallyl, 2,3,3-trichloroallyl, 2,3-dichlorobut-2-en-1-yl, 2-bromoallyl, 3-bromoallyl, 2,3-dibromoallyl, 3,3-dibromoallyl, 2,3,3-tribromoallyl or 2,3-dibromobut-2-en-1-yl;
        C2-C10-haloalkynyl: C2-C10-alkynyl as mentioned above in which 1 to 6 hydrogen atoms are substituted by halogen atoms, preferably by fluorine and/or chlorine: for example 1,1-difluoroprop-2-yn-1-yl, 1,1-difluorobut-2-yn-1-yl, 4-fluorobut-2-yn-1-yl, 4-chlorobut-2-yn-1-yl, 5-fluoropent-3-yn-1-yl or 6-fluorohex-4-yn-1-yl;
        C1-C10-cyanoalkyl: C1-C10-alkyl substituted by a CN group, for example cyanomethyl, 1-cyanoethyl, 2-cyanoethyl, 1-cyanopropyl, 2-cyanopropyl, 3-cyanopropyl, 1-cyanoprop-2-yl, 2-cyanoprop-2-yl, 1-cyanobutyl, 2-cyanobutyl, 3-cyanobutyl, 4-cyanobutyl, 1-cyanobut-2-yl, 2-cyanobut-2-yl, 1-cyanobut-3-yl, 2-cyanobut-3-yl, 1-cyano-2-methylprop-3-yl, 2-cyano-2-methylprop-3-yl, 3-cyano-2-methylprop-3-yl, 3-cyano-2,2-dimethylpropyl, 6-cyanohex-1-yl, 7-cyanohept-1-yl, 8-cyanooct-1-yl, 9-cyanonon-1-yl, 10-cyanodec-1-yl;
        C3-C10-cycloalkyl: a cycloaliphatic radical having 3 to 10 carbon atoms: for example cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl or cyclodecyl;
        C3-C10-cycloalkenyl: a cycloaliphatic radical having 3 to 10 carbon atoms and a double bond: for example cyclopropen-1-yl, cyclobuten-1-yl, cyclopenten-1-yl, cyclohexen-1-yl, cyclohepten-1-yl, cycloocten-1-yl, cyclononen-1-yl, cyclodecen-1-yl, cyclopent-2-en-1-yl, cyclohex-2-en-1-yl, cyclohept-2-en-1-yl, cyclooct-2-en-1-yl, cyclonon-2-en-1-yl, cyclodec-2-en-1-yl, cyclohex-3-en-1-yl, cyclohept-3-en-1-yl, cyclooct-3-en-1-yl, cyclooct-4-en-1-yl, cyclonon-3-en-1-yl, cyclonon-4-en-1-yl, cyclodec-4-en-1-yl or cyclodec-3-en-1-yl;
        C1-C4-alkylcarbonyl: an alkyl radical having 1 to 4 carbon atoms which is attached via a carbonyl group, for example acetyl, propionyl, butyryl or isobutyryl;
        (C1-C4-alkylamino)carbonyl: for example methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, 1-methylethylaminocarbonyl, butylaminocarbonyl, 1-methylpropylaminocarbonyl, 2-methylpropylaminocarbonyl or 1,1-dimethylethylaminocarbonyl;
        di-(C1-C4-alkyl)aminocarbonyl: for example N,N-dimethylaminocarbonyl, N,N-diethylaminocarbonyl, N,N-di-(1-methylethyl)aminocarbonyl, N,N-dipropylaminocarbonyl, N,N-dibutylaminocarbonyl, N,N-di-(1-methylpropyl)aminocarbonyl, N,N-di-(2-methylpropyl)aminocarbonyl, N,N-di-(1,1-dimethylethyl)aminocarbonyl, N-ethyl-N-methylaminocarbonyl, N-methyl-N-propylaminocarbonyl, N-methyl-N-(1-methylethyl)aminocarbonyl, N-butyl-N-methylaminocarbonyl, N-methyl-N-(1-methylpropyl)aminocarbonyl, N-methyl-N-(2-methylpropyl)aminocarbonyl, N-(1,1-dimethylethyl)-N-methylaminocarbonyl, N-ethyl-N-propylaminocarbonyl, N-ethyl-N-(1-methylethyl)aminocarbonyl, N-butyl-N-ethylaminocarbonyl, N-ethyl-N-(1-methylpropyl)aminocarbonyl, N-ethyl-N-(2-methylpropyl)aminocarbonyl, N-ethyl-N-(1,1-dimethylethyl)aminocarbonyl, N-(1-methylethyl)-N-propylaminocarbonyl, N-butyl-N-propylaminocarbonyl, N-(1-methylpropyl)-N-propylaminocarbonyl, N-(2-methylpropyl)-N-propylaminocarbonyl, N-(1,1-dimethylethyl)-N-propylaminocarbonyl, N-butyl-N-(1-methylethyl)aminocarbonyl, N-(1-methylethyl)-N-(1-methylpropyl)aminocarbonyl, N-(1-methylethyl)-N-(2-methylpropyl)aminocarbonyl, N-(1,1-dimethylethyl)-N-(1-methylethyl)aminocarbonyl, N-butyl-N-(1-methylpropyl)aminocarbonyl, N-butyl-N-(2-methylpropyl)aminocarbonyl, N-butyl-N-(1,1-dimethylethyl)aminocarbonyl, N-(1-methylpropyl)-N-(2-methylpropyl)aminocarbonyl, N-(1,1-dimethylethyl)-N-(1-methylpropyl)aminocarbonyl or N-(1,1-dimethylethyl)-N-(2-methylpropyl)aminocarbonyl;
        C1-C4-alkoxy: an alkyl radical having 1 to 4 carbon atoms which is attached via an oxygen atom, for example methoxy, ethoxy, propoxy, 1-methylethoxy, butoxy, 1-methylpropoxy, 2-methylpropoxy or 1,1-dimethylethoxy;
        C1-C4-alkoxycarbonyl: an alkoxy radical having 1 to 4 carbon atoms which is attached via a carbonyl group, for example methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, 1-methylethoxycarbonyl, butoxycarbonyl, 1-methylpropoxycarbonyl, 2-methylpropoxycarbonyl or 1,1-dimethylethoxycarbonyl;
        C1-C4-alkylthio (C1-C4-alkylsulfanyl: C1-C4-alkyl-S—): an alkyl radical having 1 to 4 carbon atoms which is attached via a sulfur atom, for example methylthio, ethylthio, propylthio, 1-methylethylthio, butylthio, 1-methylpropylthio, 2-methylpropylthio or 1,1-dimethylethylthio;
        C1-C4-alkylsulfinyl (C1-C4-alkyl-S(═O)—): for example methylsulfinyl, ethylsulfinyl, propylsulfinyl, 1-methylethylsulfinyl, butylsulfinyl, 1-methylpropylsulfinyl, 2-methylpropylsulfinyl or 1,1-dimethylethylsulfinyl;
        C1-C4-alkylsulfonyl (C1-C4-alkyl-S(═O)2—): for example methylsulfonyl, ethylsulfonyl, propylsulfonyl, 1-methylethylsulfonyl, butylsulfonyl, 1-methylpropylsulfonyl, 2-methylpropylsulfonyl or 1,1-dimethylethylsulfonyl;
        3- to 8-membered heterocyclyl: a heterocyclic radical which has 3, 4, 5, 6, 7 or 8 ring members, 1, 2 or 3 of the ring members being heteroatoms selected from the group consisting of oxygen, sulfur, nitrogen and a group NR6 (where R6 is hydrogen, C1-C6-alkyl, C3-C6-alkenyl or C3-C6-alkynyl). Moreover, the heterocycle may optionally have one or two carbonyl groups or thiocarbonyl groups as ring members. The heterocycle may be aromatic (heteroaryl) or partially or fully saturated.
    
    


Examples of saturated heterocycles are:

    
    
        oxiran-1-yl, aziridin-1-yl, oxetan-2-yl, oxetan-3-yl, thietan-2-yl, thietan-3-yl, azetidin-1-yl, azetidin-2-yl, azetidin-3-yl, tetrahydrofuran-2-yl, tetrahydrofuran-3-yl, tetrahydrothiophen-2-yl, tetrahydrothiophen-3-yl, pyrrolidin-1-yl, pyrrolidin-2-yl, pyrrolidin-3-yl, 1,3-dioxolan-2-yl, 1,3-dioxolan-4-yl, 1,3-oxathiolan-2-yl, 1,3-oxathiolan-4-yl, 1,3-oxathiolan-5-yl, 1,3-oxazolidin-2-yl, 1,3-oxazolidin-3-yl, 1,3-oxazolidin-4-yl, 1,3-oxazolidin-5-yl, 1,2-oxazolidin-2-yl, 1,2-oxazolidin-3-yl, 1,2-oxazolidin-4-yl, 1,2-oxazolidin-5-yl, 1,3-dithiolan-2-yl, 1,3-dithiolan-4-yl, pyrrolidin-1-yl, pyrrolidin-2-yl, pyrrolidin-5-yl, tetrahydropyrazol-1-yl, tetrahydropyrazol-3-yl, tetrahydropyrazol-4-yl, tetrahydropyran-2-yl, tetrahydropyran-3-yl, tetrahydropyran-4-yl, tetrahydrothiopyran-2-yl, tetrahydrothiopyran-3-yl, tetrahydropyran-4-yl, piperidin-1-yl, piperidin-2-yl, piperidin-3-yl, piperidin-4-yl, 1,3-dioxan-2-yl, 1,3-dioxan-4-yl, 1,3-dioxan-5-yl, 1,4-dioxan-2-yl, 1,3-oxathian-2-yl, 1,3-oxathian-4-yl, 1,3-oxathian-5-yl, 1,3-oxathian-6-yl, 1,4-oxathian-2-yl, 1,4-oxathian-3-yl, morpholin-2-yl, morpholin-3-yl, morpholin-4-yl, hexahydropyridazin-1-yl, hexahydropyridazin-3-yl, hexahydropyridazin-4-yl, hexahydropyrimidin-1-yl, hexahydropyrimidin-2-yl, hexahydropyrimidin-4-yl, hexahydropyrimidin-5-yl, piperazin-1-yl, piperazin-2-yl, piperazin-3-yl, hexahydro-1,3,5-triazin-1-yl, hexahydro-1,3,5-triazin-2-yl, oxepan-2-yl, oxepan-3-yl, oxepan-4-yl, thiepan-2-yl, thiepan-3-yl, thiepan-4-yl, 1,3-dioxepan-2-yl, 1,3-dioxepan-4-yl, 1,3-dioxepan-5-yl, 1,3-dioxepan-6-yl, 1,3-dithiepan-2-yl, 1,3-dithiepan-4-yl, 1,3-dithiepan-5-yl, 1,3-dithiepan-2-yl, 1,4-dioxepan-2-yl, 1,4-dioxepan-7-yl, hexahydroazepin-1-yl, hexahydroazepin-2-yl, hexahydroazepin-3-yl, hexahydroazepin-4-yl, hexahydro-1,3-diazepin-1-yl, hexahydro-1,3-diazepin-2-yl, hexahydro-1,3-diazepin-4-yl, hexahydro-1,4-diazepin-1-yl and hexahydro-1,4-diazepin-2-yl;
        examples of unsaturated heterocycles are: dihydrofuran-2-yl, 1,2-oxazolin-3-yl, 1,2-oxazolin-5-yl, 1,3-oxazolin-2-yl;
        examples of aromatic heterocyclyl are the 5- and 6-membered aromatic heterocyclic radicals, for example furyl, such as 2-furyl and 3-furyl, thienyl, such as 2-thienyl and 3-thienyl, pyrrolyl, such as 2-pyrrolyl and 3-pyrrolyl, isoxazolyl, such as 3-isoxazolyl, 4-isoxazolyl and 5-isoxazolyl, isothiazolyl, such as 3-isothiazolyl, 4-isothiazolyl and 5-isothiazolyl, pyrazolyl, such as 3-pyrazolyl, 4-pyrazolyl and 5-pyrazolyl, oxazolyl, such as 2-oxazolyl, 4-oxazolyl and 5-oxazolyl, thiazolyl, such as 2-thiazolyl, 4-thiazolyl and 5-thiazolyl, imidazolyl, such as 2-imidazolyl and 4-imidazolyl, oxadiazolyl, such as 1,2,4-oxadiazol-3-yl, 1,2,4-oxadiazol-5-yl and 1,3,4-oxadiazol-2-yl, thiadiazolyl, such as 1,2,4-thiadiazol-3-yl, 1,2,4-thiadiazol-5-yl and 1,3,4-thiadiazol-2-yl, triazolyl, such as 1,2,4-triazol-1-yl, 1,2,4-triazol-3-yl and 1,2,4-triazol-4-yl, pyridinyl, such as 2-pyridinyl, 3-pyridinyl and 4-pyridinyl, pyridazinyl, such as 3-pyridazinyl and 4-pyridazinyl, pyrimidinyl, such as 2-pyrimidinyl, 4-pyrimidinyl and 5-pyrimidinyl, furthermore 2-pyrazinyl, 1,3,5-triazin-2-yl and 1,2,4-triazin-3-yl, in particular pyridyl, furanyl and thienyl.
    
    


The radical A, which is derived from a primary or secondary amine, is generally a group of the formula —NR1R2,
where the variables R1 and R2 are as defined below:


    R1 and R2 independently of one another represent hydrogen, C1-C10-alkyl, C2-C10-alkenyl or C2-C10-alkynyl which may be unsubstituted or substituted by one of the following radicals: C1-C4-alkoxy, C1-C4-alkylthio, CN, NO2, formyl, C1-C4-alkylcarbonyl, C1-C4-alkoxycarbonyl, C1-C4-alkylaminocarbonyl, C1-C4-dialkylaminocarbonyl, C1-C4-alkylsulfinyl, C1-C4-alkylsulfonyl, C3-C10-cycloalkyl, 3- to 8-membered heterocyclyl having one, two or three heteroatoms selected from the group consisting of O, S, N and a group NR6 (where R6 is hydrogen, C1-C8-alkyl, C3-C6-alkenyl or C3-C6-alkynyl), phenyl, which for its part may have 1, 2, 3 or 4 substituents selected from the group consisting of halogen, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-fluoroalkyl, C1-C4-alkyloxycarbonyl, trifluoromethylsulfonyl, C1-C3-alkylamino, C1-C3-dialkylamino, formyl, nitro and cyano,
    
        C1-C10-haloalkyl, C2-C10-haloalkenyl, C2-C10-haloalkynyl, C3-C8-cycloalkyl, C3-C10-cycloalkenyl, 3- to 8-membered heterocyclyl having one to three heteroatoms selected from the group consisting of O, S, N and a group NR6 (where R6 is hydrogen, C1-C8-alkyl, C3-C6-alkenyl or C3-C6-alkynyl), phenyl or naphthyl, where C3-C8-cycloalkyl, C3-C10-cycloalkenyl, 3- to 8-membered heterocyclyl, phenyl and naphthyl may for their part have 1, 2, 3 or 4 substituents selected from the group consisting of halogen, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-fluoroalkyl, C1-C4-alkyloxycarbonyl, trifluoromethylsulfonyl, formyl, C1-C3-alkylamino, C1-C3-dialkylamino, phenoxy, nitro and cyano, or
    
    
    R1 and R2 together form a saturated or partially unsaturated 5- to 8-membered nitrogen heterocycle which for its part may be substituted by C1-C4-alkyl, C1-C4-alkoxy and/or C1-C4-haloalkyl and may have one or two carbonyl groups, thiocarbonyl groups and/or one or two further heteroatoms selected from the group consisting of O, S, N and a group NR6 (where R6 is as defined above) as ring members.


Preferred substituents R1 and R2 are, independently of one another, selected from the group consisting of hydrogen, C1-C6-alkyl, which is unsubstituted or substituted by a substituent selected from the group consisting of halogen, cyano, C1-C4-alkoxy, C1-C4-alkoxycarbonyl, C1-C4-alkylthio, C3-C8-cycloalkyl, phenyl, which for its part is unsubstituted or substituted by halogen or C1-C4-alkoxy, furyl, thienyl, 1,3-dioxolanyl. Preference is furthermore given to C2-C6-alkenyl, C2-C6-alkynyl, C3-C8-cycloalkyl or phenyl, which is unsubstituted or substituted by 1 or 2 substituents selected from the group consisting of halogen, C1-C4-alkyl, C1-C4-fluoroalkyl, C1-C4-alkoxy, C1-C4-alkoxycarbonyl, nitro and C1-C3-dialkylamino, naphthtyl or pyridyl. In a further preferred embodiment, R1 and R2 together form a five-, six- or seven-membered saturated or unsaturated nitrogen heterocycle which may contain a further heteroatom selected from the group consisting of N, a group NR6 (where R6 is as defined above) and O as ring member and/or may be substituted by one, two or three substituents selected from the group consisting of C1-C4-alkyl and C1-C4-haloalkyl.
In particularly preferred embodiment of the invention, one of the radicals R1 or R2 is hydrogen, C1-C6-alkyl, C2-C8-alkenyl or C2-C6-alkynyl and the other radical R1 or R2 is C1-C6-alkyl, C3-C8-cycloalkyl or phenyl.
The group Ar is in particular a group of the formula Ar-1




where

    Ra, Rb, Rc and Rd independently of one another are hydrogen, halogen, C1-C4-haloalkyl or cyano;
    * denotes the point of attachment of Ar to the C(O) group and
    ** denotes the point of attachment of Ar to the nitrogen atom of the amino, nitro or iso(thio)cyanato group.


In a particularly preferred embodiment of the invention, the variables Ra, Rb, Rc and Rd are as defined below, in each case on their own or in combination:

    Ra is halogen or cyano, in particular fluorine, chlorine or cyano;
    Rb is hydrogen;
    Rc is halogen or hydrogen, in particular fluorine, chlorine or hydrogen;
    Rd is hydrogen.


Accordingly, the present invention relates in particular to the preparation of the compounds IA,




where the variables Ra, Rb, Rc, Rd, A and W are as defined above.

In particular, the present invention relates to the preparation of the compounds IA.1 where A is NR1R2. Hereinbelow, these compounds are referred to as compounds IA.1.




The reaction of the compound II with phosgene, thiophosgene or diphosgene, hereinbelow also referred to as phosgenating agent, is usually carried out in an inert organic solvent. Suitable solvents for these reactions are—depending on the temperature range—hydrocarbons, such as pentane, hexane, cyclopentane, cyclohexane, toluene, xylene; chlorinated hydrocarbons, such as methylene chloride, chloroform, 1,2-dichloroethane, 1,1,2,2-tetrachloroethane, chlorobenzene, 1,2-, 1,3- or 1,4-dichlorobenzene, ethers, such as 1,4-dioxane, anisole; glycol ethers, such as dimethyl glycol ether, diethyl glycol ether, diethylene glycol dimethyl ether; esters, such as ethyl acetate, propyl acetate, methyl isobutyrate, isobutyl acetate; carboxamides, such as N,N-dimethylformamide, N-methylpyrrolidone; nitrated hydrocarbons, such as nitrobenzene; tetraalkylureas such as tetraethylurea, tetrabutylurea, dimethylethyleneurea, dimethylpropyleneurea; nitriles, such as acetonitrile, propionitrile, butyronitrile or isobutyronitrile; or else mixtures of individual solvents.
If phosgene is used, preference is given to using a solvent which is substantially free of protic impurities such as water and alcohols. However, in the preparation of the isothiocyanates, it is also possible, similarly to Houben-Weyl, Methoden der organischen Chemie, 4th edition, Vol. IX, p. 875, to carry out the reaction of II with thiophosgene in a two-phase system comprising water and a water-immiscible organic solvent, or else in water.
In general, the compound II is initially charged in a reaction vessel, preferably as a solution or suspension in one of the solvents mentioned above, and the phosgenating agent is then added. The addition of the phosgenating agent is preferably carried out with stirring. The addition preferably takes place over a period of from 10 to 60 minutes. The phosgenating agent can be added as such or as a solution in one of the solvents mentioned above. In the case of phosgene, this is generally introduced into the solution or suspension.
The reaction temperature will generally not exceed 180° C., preferably 120° C. and in particular 100° C., and will generally be at least 40° C. and preferably at least 50° C. Frequently, at least the major part of the phosgenating agent will be added at a low temperature, for example in the range from 0 to 40° C., in particular from 10 to 40° C. and especially from 20 to 30° C., and the mixture will be heated during or after the addition to a temperature in the range from 40 to 180° C., in particular from 50 to 120° C. and especially from 70 to 100° C., until the reaction has gone to completion.
In general, from 0.9 to 2, preferably from 0.95 to 1.5, with particular preference from 0.98 to 1.09, molar equivalents of phosgenating agent are employed per mole of the compound II.
If appropriate, the conversion of II is carried out in the presence of a base. Suitable bases are, for example, basic inorganic compounds, for example alkali metal or alkaline earth metal hydroxides, bicarbonates or carbonates. However, the reaction can also be carried out in the presence of an organic base, for example a tertiary amine, such as triethylamine, tri-n-propylamine, N-ethyldiisopropylamine, pyridine, α-, β-, γ-picoline, 2,4-, 2,6-lutidine, N-methylpyrrolidine, dimethylaniline, N,N-dimethylcyclohexylamine, quinoline or acridine. The base (calculated as base equivalent) can be employed in substoichiometric, superstoichiometric or equimolar amounts, based on the compound II. In general, from 0.01 to 6 mol, preferably from 0.1 to 3 mol, of base are employed per mole of the compound II.
In another embodiment of the process according to the invention, the reaction is carried out in the presence of hydrogen chloride. In this case, the amount of hydrogen chloride is usually from 0.9 to 5.0 mol, preferably from 1.0 to 2.5 mol and in particular from 1.0 to 1.2 mol, of hydrogen chloride per mole of the compound II. The procedure usually adopted here is that the above-mentioned amount of gaseous hydrogen chloride is initially introduced into or a solution of hydrogen chloride in a solvent is initially added to a solution or suspension of the compound II in one of the abovementioned solvents, the phosgenating agent is then added in the manner described above and the reaction is then continued in the manner described above. The introduction of hydrogen chloride is usually carried out at temperatures from 10° C. to 60° C., preferably from 20° C. to 30° C.
If the process is carried out in the presence of hydrogen chloride, it is possible to use activated carbon as the catalyst. The amount of activated carbon is expediently from 1 to 10% by weight, preferably from 1 to 3% by weight, based on the weight of the compound II.
The reaction can be carried out at atmospheric pressure or under superatmospheric pressure, continuously or batch-wise. In general, the reaction of the compound II with a phosgenating agent will be carried out with exclusion of water. If appropriate, it may be advantageous to carry out the reaction under a protective atmosphere.
Work-up to isolate the target product can be carried out using the methods customary for this purpose. If the phosgenating agent used is phosgene, in general unreacted phosgene will initially be removed, for example by introducing a stream of nitrogen into the reaction mixture. The solvent is then removed by customary processes, for example by distillation. For further purification, it is possible to employ processes such as crystallization or chromatography, for example on silica gel. If appropriate, the residue can also be purified by trituration with a solvent, for example an aromatic hydrocarbon, such as benzene, toluene or xylene, or an aliphatic hydrocarbon, such as petroleum ether, hexane, cyclohexane, pentane, an ether, such as diethyl ether, etc., and mixtures of these.
The compounds of the formula II required as starting materials for carrying out the process according to the invention are likewise novel and, as interesting precursors, of importance for the process according to the invention. In the formula II, the variables Ar and A preferably denote those radicals which have already been mentioned in connection with the description of the compounds I according to the invention as being preferred for these substituents.
The compounds of the formula II can be obtained analogously to known processes for preparing anilines. The aniline compounds of the formula II can be prepared, for example, in accordance with Scheme 2 by initially reacting an aroyl compound of the formula III with a sulfamic acid amide IV in a condensation reaction to give an N-aroylsulfamic acid amide of the formula V, followed by reduction of the resulting N-aroylsulfamic acid amide V to give the compound II.




In Scheme 2, the variables A and Ar have the meanings given above, in particular the meanings given as being preferred. X is halogen, preferably chlorine, hydroxyl or a C1-C4-alkoxy group. The condensation of aroyl compounds of the formula III with sulfamic acid amides of the formula IV to give the corresponding benzoylsulfamides of the formula V is carried out similarly to known processes, for example as described in WO 01/83459, pp. 31-35, in the not yet published German patent application DE 102 21 910.0, the disclosure of which is hereby incorporated by way of reference.
The first reaction step is illustrated in more detail below:
If X in the formula III is hydroxyl, the carboxylic acid III is preferably initially activated by reaction with a coupling agent. The activated carboxylic acid III is then, generally without prior isolation, reacted with the sulfamic acid amide IV. Suitable coupling agents are, for example, N,N′-carbonyldiimidazole or carbodiimides, such as dicyclohexylcarbodiimide. These are generally employed in at least equimolar amount and up to a four-fold excess, based on the carboxylic acid III. If appropriate, the resulting reaction mixture of carboxylic acid III and coupling agent is heated and then allowed to cool to room temperature. The reaction is usually carried out in a solvent. Suitable solvents are, for example, chlorinated hydrocarbons, such as methylene chloride, 1,2-dichloroethane; ethers, for example dialkyl ethers, such as diethyl ether or methyl tert-butyl ether, or cyclic ethers, such as tetrahydrofuran or dioxane; carboxamides, such as dimethylformamide; N-methyllactams, such as N-methylpyrrolidone; nitriles, such as acetonitrile; aromatic hydrocarbons, such as toluene; aromatic amines, such as pyridine; or mixtures of these. This is followed by addition of the sulfamic acid amide IV. In general, the sulfamide IV is dissolved in the same solvent that is used for activating the carboxylic acid.
If X in the formula III is C1-C4-alkoxy, the esters can initially be converted according to known processes by hydrolysis in an acidic medium using strong mineral acids, such as concentrated hydrochloric acid or sulfuric acid, or organic acids, such as glacial acetic acid, or mixtures of these, into the corresponding carboxylic acids III. Alternatively, esters can also be hydrolyzed under alkaline conditions using bases such as alkali metal hydroxide, for example sodium hydroxide or potassium hydroxide, in the presence of water.
The carboxylic acids III (X=OH) can then be reacted in the manner described above or initially be converted into the acid chlorides (X=Cl) using a chlorinating agent, such as thionyl chloride or phosgene, followed by reaction of the acid chlorides with IV in the manner described below. The acid chlorides are prepared similarly to known processes, for example as described in EP 1 176 133 and WO 01/087872.
However, it is also possible to react the carboxylic acid ester of the formula III in which X is C1-C4-alkoxy directly with a sulfamic acid amide IV or a metal salt thereof in an amidation reaction with cleavage of the ester radical. The reaction is carried out similarly to the procedure described in Houben-Weyl, 4th edition, Vol. VIII, pp. 658-659.
If X in formula III is halogen, the aroyl compound III, preferably diluted in an inert solvent, will generally be added to the sulfamic acid amide of the formula IV, preferably likewise diluted in an inert solvent. It is, of course, also possible to initially charge the aroyl compound III and to add the sulfamic acid amide IV.
The molar ratios in which the starting materials III and IV are reacted with one another are generally from 0.9 to 1.2, preferably from 0.95 to 1.1, particularly preferably from 0.98 to 1.04, for the ratio of aroyl compound III to sulfamic acid amide IV.
The reaction is usually carried out at temperatures in the range from −30 to 100° C., preferably from −10 to 80° C., particularly preferably from 0 to 60° C.
The first reaction step is advantageously carried out under neutral conditions. If an acidic reaction product, for example hydrogen chloride (if X in formula III is halogen) is formed during the reaction, this is removed by addition of a basic compound. Suitable basic compounds include inorganic and organic bases. Suitable inorganic basic compounds are, for example, alkali metal or alkaline earth metal hydroxides, bicarbonates or carbonates. However, the reaction can also be carried out in the presence of an organic base, for example triethylamine, tri-n-propylamine, N-ethyldiisopropylamine, pyridine, α-, β-, γ-picoline, 2,4-, 2,6-lutidine, N-methylpyrrolidine, dimethylaniline, N,N-dimethylcyclohexylamine, quinoline or acridine. In general, an excess of base is employed, based on the compound III. The molar amount of base is from 1.0 to 2 mol, preferably from 1.02 to 1.3 mol, of base (calculated as base equivalent) per mole of the compound III. If appropriate, the reaction mixture contains pyridine or a pyridine compound, for example a 4-dialkylaminopyridine such as 4-dimethylaminopyridine, as catalyst. The added quantity of catalyst is about 0.1-10%, based on the compound III.
The reaction of the aroyl compounds III with the compounds of the formula IV is advantageously carried out in the presence of a solvent. Suitable solvents for these reactions are—depending on the temperature range—hydrocarbons, such as pentane, hexane, cyclopentane, cyclohexane, toluene, xylene, chlorinated hydrocarbons, such as methylene chloride, chloroform, 1,2-dichloroethane, 1,1,2,2-tetrachloroethane, chlorobenzene, 1,2-, 1,3- or 1,4-dichlorobenzene; ethers, such as 1,4-dioxane, anisole, glycol ethers, such as dimethyl glycol ether, diethyl glycol ether, diethylene glycol dimethyl ether; esters, such as ethyl acetate, propyl acetate, methyl isobutyrate, isobutyl acetate; carboxamides, such as N,N-dimethylformamide, N-methylpyrrolidone, nitrated hydrocarbons, such as nitrobenzene; tetraalkylureas, such as tetraethylurea, tetrabutylurea, dimethyl ethyleneurea, dimethylpropyleneurea; sulfoxides, such as dimethyl sulfoxide; sulfones, such as dimethyl sulfone, diethyl sulfone, tetramethylene sulfone; nitriles, such as acetonitrile, propionitrile, butyronitrile or isobutyronitrile; water; or else mixtures of individual solvents.
It is furthermore possible to carry out the reaction in an aqueous two-phase system, preferably in the presence of phase-transfer catalysts such as quaternary ammonium or phosphonium salts. Suitable reaction conditions for the two-phase reaction are those described in EP-A 556737.
Suitable for use as phase-transfer catalysts are quaternary ammonium or phosphonium salts. Suitable compounds which may be mentioned are the following: tetraalkyl-(C1-C18)-ammonium chlorides, bromides or fluorides, N-benzyltrialkyl-(C1-C18)-ammonium chlorides, bromides or fluorides, tetraalkyl-(C1-C18)-phosphonium chlorides or bromides, tetraphenylphosphonium chloride or bromide, (phenyl)o(C1-C18-alkyl)p-phosphonium chlorides or bromides, where o=1 to 3, p=3 to 1 and o+p=4. Particular preference is given to tetraethylammonium chloride and N-benzyltriethylammonium chloride. The amount of phase-transfer catalyst is generally up to 20% by weight, preferably from 1 to 15% by weight and particularly preferably from 2 to 8% by weight, based on the starting material IV.
The aroyl compound III is advantageously added over a period of from 0.25 to 2 hours to a mixture of the sulfamic acid amide IV and, if appropriate, the base in one of the above-mentioned solvents, and the mixture is stirred for another 0.5 to 16 hours, preferably 2 to 8 hours, until the reaction has gone to completion. The reaction temperature is generally from 0° C. to 60° C.
If an aqueous two-phase system is used, the starting materials III and IV can be added in any order with stirring to a mixture of the phase-transfer catalyst in the two phases, and the reaction can then be completed in the indicated temperature range by adding a base.
The reaction can be carried out continuously or batch-wise, at atmospheric pressure or under elevated pressure.
For work-up, the organic phase is extracted with dilute mineral acid such as hydrochloric acid, the organic phase is dried and the solvent is removed under reduced pressure. If appropriate, the residue can also be purified further by trituration with a solvent or solvent mixture, for example an aromatic hydrocarbon, such as benzene, xylene or toluene, or an aliphatic or cycloaliphatic hydrocarbon, such as petroleum ether, pentane, hexane or cyclohexane, an ether such as diethyl ether, etc., and mixtures of these, filtration with suction and drying.
The 2nd reaction step, i.e. the reduction of the nitro compound V to the compound II, is illustrated in more detail below.
The reduction of the compound V to the compound II can be effected, for example, using nascent hydrogen. To this end, the nitro compound is reacted with an acid in the presence of a base metal. According to their nature, base metals are dissolved by a Brönsted acid with evolution of hydrogen. Such metals generally have a normal potential of <0 V and in particular of ≦−0.1 V, for example in the range of from −0.1 to −1.0 V (in acidic aqueous solution at 15° C. and 1 bar). Examples of suitable metals are Zn, Fe and Sn, in particular Fe. Acids suitable for this purpose are both inorganic mineral acids, for example hydrochloric acid or dilute sulfuric acid, or mixtures of inorganic acid or one of the solvents mentioned above, for example gaseous HCl in an ether or an alcohol or a mixture thereof, and organic carboxylic acids, expediently acetic acid, propionic acid or butyric acid.
The reaction conditions correspond substantially to the reaction conditions used for reducing aliphatic or aromatic nitro groups to aliphatic or aromatic amino groups with nascent hydrogen (see, for example, H. Koopman, Rec. Trav. 80 (1961), 1075; see also N. Kornblum, L. Fischbein, J. Am. Chem. Soc. 77, (1955) 6266).
Depending on the type of metal and acid, the reaction temperature is generally in the range of from −20 to +120° C., with temperatures in the range of from 50 to 100° C. being preferred if alkanoic acids such as acetic acid are used. The reaction time can be from a few minutes to a number of hours, for example from about 20 minutes to 5 hours. Preferably, the compound V to be reduced is initially charged to the reaction vessel and the metal in question is then, preferably in finely divided form, in particular as a powder, added with mixing to the reaction mixture. The addition is preferably carried out over a period of from 10 minutes to 2 hours. It is, of course, also possible to initially charge the metal and the acid and to add the compound V, if appropriate together with an inert solvent. Frequently, the reaction mixture is allowed some extra reaction time at reaction temperature, for example from 10 minutes to 4 hours.
The reduction of V to II is preferably carried out using iron powder in dilute acid. Suitable acids are mineral acids, such as hydrochloric acid, or organic acids, such as formic acid, acetic acid, propionic acid, butyric acid. Preference is given to using acetic acid. The amount of iron powder is preferably from 2 to 5 mol, in particular from 2.5 to 4 mol, per mole of the compound V. The amount of acid is generally not critical. It is expedient to use an at least equimolar amount of acid, based on the nitro compound V, to reduce the starting material as completely as possible. The reaction can be carried out continuously or batch-wise. In this case, the reaction temperatures are in the range of from 50 to 100° C., preferably from 65 to 75° C. In one embodiment, for example, the iron powder is initially charged in acetic acid and the compound V is then added to the reaction vessel. The addition is preferably carried out over a period of from 20 to 60 minutes, with mixing of the components, for example by stirring. After the addition has ended, the mixture is allowed to react at reaction temperature for another 0.5 to 2 hours, preferably for about 1 hour. However, it is also possible to add the iron powder with stirring to the mixture of the compound V in glacial acetic acid and to bring the reaction to completion as described above.
Work-up for the isolation of the target product can be carried out by processes customary for this purpose. In general, the solvent is initially removed, for example by distillation. For further purification, it is possible to employ customary processes such as crystallization, chromatography, for example on silica gel, trituration with a solvent, for example an aromatic hydrocarbon, such as benzene, toluene or xylene, or an aliphatic hydrocarbon, such as petroleum ether, hexane, cyclohexane, pentane, a carboxylic ester, such as ethyl acetate, etc., and mixtures of these.
Suitable reducing agents are furthermore also metal hydrides and semimetal hydrides, such as aluminum hydride and hydrides derived therefrom, such as lithium aluminum hydride, diisobutylaluminum hydride; borohydrides, such as diborane and boranates derived therefrom, such as sodium borohydride or lithium borohydride. To this end, the nitro compound V is, in an inert solvent, brought into contact with the complex metal hydride at 10-65° C., advantageously at 20-50° C. The reaction time is preferably from 2 to 10 hours, advantageously from 3 to 6 hours. Reaction is preferably carried out in an organic solvent which is inert to the reducing agent. Suitable solvents are—depending on the chosen reducing agent—for example alcohols, e.g. C1-C4-alcohols, such as methanol, ethanol, n-propanol, isopropanol or n-butanol, and their mixtures with water, or ethers, such as diisopropyl ether, methyl tert-butyl ether, ethylene glycol dimethyl ether, dioxane or tetrahydrofuran.
In general, from 0.5 to 3, advantageously from 0.75 to 2.5, mol of metal hydride, semimetal hydride, borohydride or boranate are employed per mole of nitro compound V. The process follows the procedure described in Organikum, VEB Deutscher Verlag der Wissenschaften, Berlin 1976, 15th edition, pp. 612-616.
A further reducing agent suitable for converting the compound V into the compound II is hydrogen in the presence of catalytic amounts of transition metals or transition metal compounds, in particular those of the 8th transition group. Preferred transition metals are, for example, nickel, palladium, platinum, ruthenium or rhodium. The transition metals can be employed as such or in supported form. Examples of supports are activated carbon, alumina, ZrO2, TiO2, SiO2, carbonates and the like. The transition metals can also be employed in the form of activated metals such as Raney nickel. The transition metals can also be used in the form of compounds. Suitable transition metal compounds are, for example, palladium oxide and platinum oxide. The catalysts are generally employed in an amount of from 0.05 to 10.0 mol % (calculated as metal), based on the compound V to be reduced. The reaction is carried out either in the absence of a solvent or in an inert solvent or diluent. Solvents or diluents suitable for the reaction are, depending on the solubility of the substrate to be hydrated and the chosen reducing agent, for example carboxylic acids, such as acetic acid, or aqueous solutions of organic acids, such as acetic acid and water, carboxylic acid esters, such as ethyl acetate, C1-C4-alcohols, such as methanol, ethanol, n-propanol, isopropanol, n-butanol or aromatic hydrocarbons, such as toluene. Following removal of the catalyst, the reaction solution can be worked up in a customary manner to afford the product. The hydration can be carried out at atmospheric pressure or under an elevated hydrogen pressure, for example at a hydrogen pressure of from 0.01 to 50 bar, preferably from 0.1 to 40 bar. For the catalytic hydration of aromatic nitro compounds, see, for example, Rylander in “Catalytic Hydrogenation over Platinum Metals”, Academic Press, New York, 1967, 168-202; Furst et al., Chem. Rev. 65 (1965), 52; Tepko et al., J. Org. Chem. 45, (1980), 4992.
In the case of chlorine-containing benzoylsulfamides, the hydration is, depending on the sensitivity of the substituents, carried out at from 20 to 170° C., expediently at from 20 to 140° C., advantageously at from 20 to 80° C. In the case of reactive halogen substituents, it is furthermore recommended to carry out the hydration in neutral solution, preferably at only slightly elevated pressure, using small amounts of nickel, platinum or else rhodium catalysts; also suitable are noble metal sulfides, such as platinum sulfide. The process is described in detail in Houben-Weyl, “Methoden der organischen Chemie”, Vol. IV/1C, pp. 520-526.
The reduction of the compound V to the compound II can also be carried out using sodium sulfide, advantageously in aqueous ammonia solution, in the presence of ammonium chloride, in accordance with the process described in Org. Syn., Coll. Vol., 3 (1955), 82. The reaction temperature is generally from 40 to 90° C., preferably from 60 to 80° C. Expediently, from 3 to 4 mol of sodium sulfide are employed per mol of nitro compound V.
The aroyl compounds III used in Scheme 2 can be obtained by processes known in the prior art or be prepared similarly to known processes, for example in accordance with U.S. Pat. No. 6,251,829, EP 415 641, EP 908 457, EP 1176133 and WO 01/087872.
The sulfamic acid amides IV are known in the prior art or can be prepared by known processes, for example in accordance with the German patent application DE 102 21 910.0 by reaction of ammonia with sulfamic acid halides. The disclosure of this publication is hereby incorporated by way of reference.
The sulfamic acid amides IV are preferably prepared by the process described in the not yet published German patent application DE 102 21 910.0. This process comprises the following steps: (i) reaction of a primary or secondary amine with an at least equimolar amount of SO3 or an SO3 source in the presence of at least equimolar amounts of a tertiary amine, based in each case on the primary or secondary amine, giving an amidosulfonic acid ammonium salt; (ii) reaction of the amidosulfonic acid ammonium salt with an at least stoichiometric amount of a phosphorus halide, giving a sulfamic acid halide, and (iii) reaction of the sulfamic acid halide obtained in step ii) with ammonia, giving the sulfamic acid amide V.
The process according to the invention allows, for the first time, the preparation of iso(thio)cyanatobenzoylsulfamic acid amides of the formula I. The compounds I are novel and also form part of the subject-matter of the present invention.
Among the iso(thio)cyanatobenzoylsulfamic acid amides of the formula I, preference is given to those of the formula IA, where the variables Ra, Rb, Rc, Rd are as defined above.
Very particular preference is given to the compounds of the formula IA.1,




where the variables R1, R2, Ra, Rb, Rc, Rd are as defined above.

Among the iso(thio)cyanatobenzoylsulfamic acid amides of the formula IA.1, particular preference is given to those in which the variables R1, R2, Ra, Rb, Rc, Rd independently of one another, but preferably in combination, are as defined below:

    Ra is cyano or halogen, in particular cyano, fluorine or chlorine;
    Rb is hydrogen;
    Rc is hydrogen or halogen, in particular hydrogen, fluorine or chlorine;
    Rd is hydrogen;
    R1 and R2 independently of one another are hydrogen, C1-C6-alkyl which is optionally substituted by a substituent selected from the group consisting of halogen, cyano, C1-C4-alkoxy, C1-C4-alkoxycarbonyl, C1-C4-alkylthio, C3-C8-cycloalkyl, furyl, thienyl, 1,3-dioxolanyl, phenyl which for its part is optionally substituted by halogen or C1-C4-alkoxy,
    
        C2-C6-alkenyl, C2-C6-alkynyl, C3-C8-cycloalkyl or phenyl which is optionally substituted by 1 or 2 substituents selected from the group consisting of halogen, C1-C4-alkyl, C1-C4-fluoroalkyl, C1-C4-alkoxy, C1-C4-alkoxycarbonyl, nitro and C1-C3-dialkylamino, naphthtyl or pyridyl or
    
    
    R1 and R2 together form a five-, six- or seven-membered saturated or unsaturated nitrogen heterocycle which may optionally contain a further heteroatom selected from the group consisting of N, a group NR6 (where R6 is as defined above) and O as ring member and/or which may be substituted by one, two or three substituents selected from the group consisting of C1-C4-alkyl and C1-C4-halogenalkyl.


In particular, one of the radicals R1 or R2 is hydrogen, C1-C6-alkyl, C2-C6-alkenyl or C2-C6-alkynyl and the other radical R1 or R2 is C1-C6-alkyl, C3-C8-cycloalkyl or phenyl.
Very particular preference is given to the isocyanatobenzoylsulfamic acid amides of the formula IA.1-a (≡I where W=oxygen, Ar=Ar-1 where Ra=Cl and Rb=Rd=hydrogen and Rc=F, A=NR1R2), where R1, R2 have the meanings mentioned above, and in particular the meanings mentioned as being preferred. Examples of such compounds are the compounds IA.1-a.1 to IA.1-a.495 in which the variables R1, R2 together have the meanings given in one row of Table 1.








TABLE 1








(IA.1-a)













 









No.
R1
R2












1
H
CH3


2
H
C2H5


3
H
CH2CH2—Cl


4
H
CH2CH2—CN


5
H
CH2—CO—OCH3


6
H
CH2—CO—OC2H5


7
H
CH(CH3)—CO—OCH3


8
H
CH2CH2—OCH3


9
H
CH2—C2H5


10
H
CH2CH2—C2H5


11
H
CH(CH3)2


12
H
CH(CH3)—C2H5


13
H
CH2—CH(CH3)2


14
H
C(CH3)3


15
H
CH(CH3)—CH2—C2H5


16
H
CH2—CH(CH3)—C2H5


17
H
CH2CH2—CH(CH3)2


18
H
CH2—CH═CH2


19
H
CH(CH3)═CH2


20
H
CH2═CH—CH3


21
H
CH2—C≡CH


22
H
CH(CH3)—C≡CH


23
H
cyclopropyl


24
H
CH2-cyclopropyl


25
H
cyclopentyl


26
H
CH2-cyclopentyl


27
H
CH2-(1,3-dioxolan-2-yl)


28
H
CH2-(2-furyl)


29
H
CH2-(3-furyl)


30
H
CH2-(2-thienyl)


31
H
CH2-(3-thienyl)


32
H
phenyl


33
H
2-chlorophenyl


34
H
3-chlorophenyl


35
H
4-chlorophenyl


36
H
2-fluorophenyl


37
H
3-fluorophenyl


38
H
4-fluorophenyl


39
H
2-methylphenyl


40
H
3-methylphenyl


41
H
4-methylphenyl


42
H
2-methoxyphenyl


43
H
3-methoxyphenyl


44
H
4-methoxyphenyl


45
H
2-(methoxycarbonyl)phenyl


46
H
3-(methoxycarbonyl)phenyl


47
H
4-(methoxycarbonyl)phenyl


48
H
2-nitrophenyl


49
H
3-nitrophenyl


50
H
4-nitrophenyl


51
H
2-(dimethylamino)phenyl


52
H
3-(dimethylamino)phenyl


53
H
4-(dimethylamino)phenyl


54
H
2-(trifluoromethyl)phenyl


55
H
3-(trifluoromethyl)phenyl


56
H
4-(trifluoromethyl)phenyl


57
H
3-(phenoxy)phenyl


58
H
4-(phenoxy)phenyl


59
H
2,4-difluorophenyl


60
H
2,4-dichlorophenyl


61
H
3,4-difluorophenyl


62
H
3,4-dichlorophenyl


63
H
3,5-difluorophenyl


64
H
3,5-dichlorophenyl


65
H
2-pyridyl


66
H
3-pyridyl


67
H
4-pyridyl


68
H
α-naphthyl


69
H
benzyl


70
H
2-chlorobenzyl


71
H
3-chlorobenzyl


72
H
4-chlorobenzyl


73
H
2-methoxybenzyl


74
H
3-methoxybenzyl


75
H
4-methoxybenzyl


76
CH3
CH3


77
CH3
C2H5


78
CH3
CH2CH2—Cl


79
CH3
CH2CH2—CN


80
CH3
CH2—CO—OCH3


81
CH3
CH2—CO—OC2H5


82
CH3
CH(CH3)—CO—OCH3


83
CH3
CH2CH2—OCH3


84
CH3
CH2—C2H5


85
CH3
CH2CH2—C2H5


86
CH3
CH(CH3)2


87
CH3
CH(CH3)—C2H5


88
CH3
CH2—CH(CH3)2


89
CH3
C(CH3)3


90
CH3
CH(CH3)—CH2—C2H5


91
CH3
CH2—CH(CH3)—C2H5


92
CH3
CH2CH2—CH(CH3)2


93
CH3
CH2—CH═CH2


94
CH3
CH(CH3)═CH2


95
CH3
CH2═CH—CH3


96
CH3
CH2—C≡CH


97
CH3
CH(CH3)—C≡CH


98
CH3
cyclopropyl


99
CH3
CH2-cyclopropyl


100
CH3
cyclopentyl


101
CH3
CH2-cyclopentyl


102
CH3
CH2-(1,3-dioxolan-2-yl)


103
CH3
CH2-(2-furyl)


104
CH3
CH2-(3-furyl)


105
CH3
CH2-(2-thienyl)


106
CH3
CH2-(3-thienyl


107
CH3
phenyl


108
CH3
2-chlorophenyl


109
CH3
3-chlorophenyl


110
CH3
4-chlorophenyl


111
CH3
2-fluorophenyl


112
CH3
3-fluorophenyl


113
CH3
4-fluorophenyl


114
CH3
2-methylphenyl


115
CH3
3-methylphenyl


116
CH3
4-methylphenyl


117
CH3
2-methoxyphenyl


118
CH3
3-methoxyphenyl


119
CH3
4-methoxyphenyl


120
CH3
2-(methoxycarbonyl)phenyl


121
CH3
3-(methoxycarbonyl)phenyl


122
CH3
4-(methoxycarbonyl)phenyl


123
CH3
2-nitrophenyl


124
CH3
3-nitrophenyl


125
CH3
4-nitrophenyl


126
CH3
2-(dimethylamino)phenyl


127
CH3
3-(dimethylamino)phenyl


128
CH3
4-(dimethylamino)phenyl


129
CH3
2-(trifluoromethyl)phenyl


130
CH3
3-(trifluoromethyl)phenyl


131
CH3
4-(trifluoromethyl)phenyl


132
CH3
3-(phenoxy)phenyl


133
CH3
4-(phenoxy)phenyl


134
CH3
2,4-difluorophenyl


135
CH3
2,4-dichlorophenyl


136
CH3
3,4-difluorophenyl


137
CH3
3,4-dichlorophenyl


138
CH3
3,5-difluorophenyl


139
CH3
3,5-dichlorophenyl


140
CH3
2-pyridyl


141
CH3
3-pyridyl


142
CH3
4-pyridyl


143
CH3
α-naphthyl


144
CH3
benzyl


145
CH3
2-chlorobenzyl


146
CH3
3-chlorobenzyl


147
CH3
4-chlorobenzyl


148
CH3
2-methoxybenzyl


149
CH3
3-methoxybenzyl


150
CH3
4-methoxybenzyl


151
C2H5
C2H5


152
C2H5
CH2CH2—Cl


153
C2H5
CH2CH2—CN


154
C2H5
CH2—CO—OCH3


155
C2H5
CH2—CO—OC2H5


156
C2H5
CH(CH3)—CO—OCH3


157
C2H5
CH2CH2—OCH3


158
C2H5
CH2—C2H5


159
C2H5
CH2CH2—C2H5


160
C2H5
CH(CH3)2


161
C2H5
CH(CH3)—C2H5


162
C2H5
CH2—CH(CH3)2


163
C2H5
C(CH3)3


164
C2H5
CH(CH3)—CH2—C2H5


165
C2H5
CH2—CH(CH3)—C2H5


166
C2H5
CH2CH2—CH(CH3)2


167
C2H5
CH2—CH═CH2


168
C2H5
CH(CH3)═CH2


169
C2H5
CH2═CH—CH3


170
C2H5
CH2—C≡CH


171
C2H5
CH(CH3)—C≡CH


172
C2H5
cyclopropyl


173
C2H5
CH2-cyclopropyl


174
C2H5
cyclopentyl


175
C2H5
CH2-cyclopentyl


176
C2H5
CH2-(1,3-dioxolan-2-yl)


177
C2H5
CH2-(2-furyl)


178
C2H5
CH2-(3-furyl)


179
C2H5
CH2-(2-thienyl)


180
C2H5
CH2-(3-thienyl)


181
C2H5
phenyl


182
C2H5
2-chlorophenyl


183
C2H5
3-chlorophenyl


184
C2H5
4-chlorophenyl


185
C2H5
2-fluorophenyl


186
C2H5
3-fluorophenyl


187
C2H5
4-fluorophenyl


188
C2H5
2-methylphenyl


189
C2H5
3-methylphenyl


190
C2H5
4-methylphenyl


191
C2H5
2-methoxyphenyl


192
C2H5
3-methoxyphenyl


193
C2H5
4-methoxyphenyl


194
C2H5
2-(methoxycarbonyl)phenyl


195
C2H5
3-(methoxycarbonyl)phenyl


196
C2H5
4-(methoxycarbonyl)phenyl


197
C2H5
2-nitrophenyl


198
C2H5
3-nitrophenyl


199
C2H5
4-nitrophenyl


200
C2H5
2-(dimethylamino)phenyl


201
C2H5
3-(dimethylamino)phenyl


202
C2H5
4-(dimethylamino)phenyl


203
C2H5
2-(trifluoromethyl)phenyl


204
C2H5
3-(trifluoromethyl)phenyl


205
C2H5
4-(trifluoromethyl)phenyl


206
C2H5
3-(phenoxy)phenyl


207
C2H5
4-(phenoxy)phenyl


208
C2H5
2,4-difluorophenyl


209
C2H5
2,4-dichlorophenyl


210
C2H5
3,4-difluorophenyl


211
C2H5
3,4-dichlorophenyl


212
C2H5
3,5-difluorophenyl


213
C2H5
3,5-dichlorophenyl


214
C2H5
2-pyridyl


215
C2H5
3-pyridyl


216
C2H5
4-pyridyl


217
C2H5
α-naphthyl


218
C2H5
benzyl


219
C2H5
2-chlorobenzyl


220
C2H5
3-chlorobenzyl


221
C2H5
4-chlorobenzyl


222
C2H5
2-methoxybenzyl


223
C2H5
3-methoxybenzyl


224
C2H5
4-methoxybenzyl


225
CH2—C2H5
C2H5


226
CH2—C2H5
CH2CH2—Cl


227
CH2—C2H5
CH2CH2—CN


228
CH2—C2H5
CH2—CO—OCH3


229
CH2—C2H5
CH2—CO—OC2H5


230
CH2—C2H5
CH(CH3)—CO—OCH3


231
CH2—C2H5
CH2CH2—OCH3


232
CH2—C2H5
CH2—C2H5


233
CH2—C2H5
CH2CH2—C2H5


234
CH2—C2H5
CH(CH3)2


235
CH2—C2H5
CH(CH3)—C2H5


236
CH2—C2H5
CH2—CH(CH3)2


237
CH2—C2H5
C(CH3)3


238
CH2—C2H5
CH(CH3)—CH2—C2H5


239
CH2—C2H5
CH2—CH(CH3)—C2H5


240
CH2—C2H5
CH2CH2—CH(CH3)2


241
CH2—C2H5
CH2—CH═CH2


242
CH2—C2H5
CH(CH3)═CH2


243
CH2—C2H5
CH2═CH—CH3


244
CH2—C2H5
CH2—C≡CH


245
CH2—C2H5
CH(CH3)—C≡CH


246
CH2—C2H5
cyclopropyl


247
CH2—C2H5
CH2-cyclopropyl


248
CH2—C2H5
cyclopentyl


249
CH2—C2H5
CH2-cyclopentyl


250
CH2—C2H5
CH2-(1,3-dioxolan-2-yl)


251
CH2—C2H5
CH2-(2-furyl)


252
CH2—C2H5
CH2-(3-furyl)


253
CH2—C2H5
CH2-(2-thienyl)


254
CH2—C2H5
CH2-(3-thienyl)


255
CH2—C2H5
phenyl


256
CH2—C2H5
2-chlorophenyl


257
CH2—C2H5
3-chlorophenyl


258
CH2—C2H5
4-chlorophenyl


259
CH2—C2H5
2-fluorophenyl


260
CH2—C2H5
3-fluorophenyl


261
CH2—C2H5
4-fluorophenyl


262
CH2—C2H5
2-methylphenyl


263
CH2—C2H5
3-methylphenyl


264
CH2—C2H5
4-methylphenyl


265
CH2—C2H5
2-methoxyphenyl


266
CH2—C2H5
3-methoxyphenyl


267
CH2—C2H5
4-methoxyphenyl


268
CH2—C2H5
2-(methoxycarbonyl)phenyl


269
CH2—C2H5
3-(methoxycarbonyl)phenyl


270
CH2—C2H5
4-(methoxycarbonyl)phenyl


271
CH2—C2H5
2-nitrophenyl


272
CH2—C2H5
3-nitrophenyl


273
CH2—C2H5
4-nitrophenyl


274
CH2—C2H5
2-(dimethylamino)phenyl


275
CH2—C2H5
3-(dimethylamino)phenyl


276
CH2—C2H5
4-(dimethylamino)phenyl


277
CH2—C2H5
2-(trifluoromethyl)phenyl


278
CH2—C2H5
3-(trifluoromethyl)phenyl


279
CH2—C2H5
4-(trifluoromethyl)phenyl


280
CH2—C2H5
3-(phenoxy)phenyl


281
CH2—C2H5
4-(phenoxy)phenyl


282
CH2—C2H5
2,4-difluorophenyl


283
CH2—C2H5
2,4-dichlorophenyl


284
CH2—C2H5
3,4-difluorophenyl


285
CH2—C2H5
3,4-dichlorophenyl


286
CH2—C2H5
3,5-difluorophenyl


287
CH2—C2H5
3,5-dichlorophenyl


288
CH2—C2H5
2-pyridyl


289
CH2—C2H5
3-pyridyl


290
CH2—C2H5
4-pyridyl


291
CH2—C2H5
α-naphthyl


292
CH2—C2H5
benzyl


293
CH2—C2H5
2-chlorobenzyl


294
CH2—C2H5
3-chlorobenzyl


295
CH2—C2H5
4-chlorobenzyl


296
CH2—C2H5
2-methoxybenzyl


297
CH2—C2H5
3-methoxybenzyl


298
CH2—C2H5
4-methoxybenzyl


299
CH2—CH2—C2H5
CH2CH2—Cl


300
CH2—CH2—C2H5
CH2CH2—CN


301
CH2—CH2—C2H5
CH2—CO—OCH3


302
CH2—CH2—C2H5
CH2—CO—OC2H5


303
CH2—CH2—C2H5
CH(CH3)—CO—OCH3


304
CH2—CH2—C2H5
CH2CH2—OCH3


305
CH2—CH2—C2H5
CH2CH2—C2H5


306
CH2—CH2—C2H5
CH(CH3)2


307
CH2—CH2—C2H5
CH(CH3)—C2H5


308
CH2—CH2—C2H5
CH2—CH(CH3)2


309
CH2—CH2—C2H5
C(CH3)2


310
CH2—CH2—C2H5
CH(CH3)—CH2—C2H5


311
CH2—CH2—C2H5
CH3—CH(CH3)—C2H5


312
CH2—CH2—C2H5
CH2CH2—CH(CH3)2


313
CH2—CH2—C2H5
CH2—CH═CH2


314
CH2—CH2—C2H5
CH(CH3)═CH2


315
CH2—CH2—C2H5
CH2═CH—CH3


316
CH2—CH2—C2H5
CH2—C≡CH


317
CH2—CH2—C2H5
CH(CH3)—C≡CH


318
CH2—CH2—C2H5
cyclopropyl


319
CH2—CH2—C2H5
CH2-cyclopropyl


320
CH2—CH2—C2H5
cyclopentyl


321
CH2—CH2—C2H5
CH2-cyclopentyl


322
CH2—CH2—C2H5
CH2-(1,3-dioxolan-2-yl)


323
CH2—CH2—C2H5
CH2-(2-furyl)


324
CH2—CH2—C2H5
CH2-(3-furyl)


325
CH2—CH2—C2H5
CH2-(2-thienyl)


326
CH2—CH2—C2H5
CH2-(3-thienyl)


327
CH2—CH2—C2H5
phenyl


328
CH2—CH2—C2H5
2-chlorophenyl


329
CH2—CH2—C2H5
3-chlorophenyl


330
CH2—CH2—C2H5
4-chlorophenyl


331
CH2—CH2—C2H5
2-fluorophenyl


332
CH2—CH2—C2H5
3-fluorophenyl


333
CH2—CH2—C2H5
4-fluorophenyl


334
CH2—CH2—C2H5
2-methylphenyl


335
CH2—CH2—C2H5
3-methylphenyl


336
CH2—CH2—C2H5
4-methylphenyl


337
CH2—CH2—C2H5
2-methoxyphenyl


338
CH2—CH2—C2H5
3-methoxyphenyl


339
CH2—CH2—C2H5
4-methoxyphenyl


340
CH2—CH2—C2H5
2-(methoxycarbonyl)phenyl


341
CH2—CH2—C2H5
3-(methoxycarbonyl)phenyl


342
CH2—CH2—C2H5
4-(methoxycarbonyl)phenyl


343
CH2—CH2—C2H5
2-nitrophenyl


344
CH2—CH2—C2H5
3-nitrophenyl


345
CH2—CH2—C2H5
4-nitrophenyl


346
CH2—CH2—C2H5
2-(dimethylamino)phenyl


347
CH2—CH2—C2H5
3-(dimethylamino)phenyl


348
CH2—CH2—C2H5
4-(dimethylamino)phenyl


349
CH2—CH2—C2H5
2-(trifluoromethyl)phenyl


350
CH2—CH2—C2H5
3-(trifluoromethyl)phenyl


351
CH2—CH2—C2H5
4-(trifluoromethyl)phenyl


352
CH2—CH2—C2H5
3-(phenoxy)phenyl


353
CH2—CH2—C2H5
4-(phenoxy)phenyl


354
CH2—CH2—C2H5
2,4-difluorophenyl


355
CH2—CH2—C2H5
2,4-dichlorophenyl


356
CH2—CH2—C2H5
3,4-difluorophenyl


357
CH2—CH2—C2H5
3,4-dichlorophenyl


358
CH2—CH2—C2H5
3,5-difluorophenyl


359
CH2—CH2—C2H5
3,5-dichlorophenyl


360
CH2—CH2—C2H5
2-pyridyl


361
CH2—CH2—C2H5
3-pyridyl


362
CH2—CH2—C2H5
4-pyridyl


363
CH2—CH2—C2H5
α-naphthyl


364
CH2—CH2—C2H5
benzyl


365
CH2—CH2—C2H5
2-chlorobenzyl


366
CH2—CH2—C2H5
3-chlorobenzyl


367
CH2—CH2—C2H5
4-chlorobenzyl


368
CH2—CH2—C2H5
2-methoxybenzyl


369
CH2—CH2—C2H5
3-methoxybenzyl


370
CH2—CH2—C2H5
4-methoxybenzyl


371
CH(CH3)2
CH2CH2—Cl


372
CH(CH3)2
CH2CH2—CN


373
CH(CH3)2
CH2—CO—OCH3


374
CH(CH3)2
CH2—CO—OC2H5


375
CH(CH3)2
CH(CH3)—CO—OCH3


376
CH(CH3)2
CH2CH2—OCH3


377
CH(CH3)2
CH(CH3)2


378
CH(CH3)2
CH(CH3)—C2H5


379
CH(CH3)2
CH2—CH(CH3)2


380
CH(CH3)2
C(CH3)3


381
CH(CH3)2
CH(CH3)—CH2—C2H5


382
CH(CH3)2
CH2—CH(CH3)—C2H5


383
CH(CH3)2
CH2CH2—CH(CH3)2


384
CH(CH3)2
CH2—CH═CH2


385
CH(CH3)2
CH(CH3)═CH2


386
CH(CH3)2
CH2═CH—CH3


387
CH(CH3)2
CH2—C≡CH


388
CH(CH3)2
CH(CH3)—C≡CH


389
CH(CH3)2
cyclopropyl


390
CH(CH3)2
CH2-cyclopropyl


391
CH(CH3)2
cyclopentyl


392
CH(CH3)2
CH2-cyclopentyl


393
CH(CH3)2
CH2-(1,3-dioxolan-2-yl)


394
CH(CH3)2
CH2-(2-furyl)


395
CH(CH3)2
CH2-(3-furyl)


396
CH(CH3)2
CH2-(2-thienyl)


397
CH(CH3)2
CH2-(3-thienyl)


398
CH(CH3)2
phenyl


399
CH(CH3)2
2-chlorophenyl


400
CH(CH3)2
3-chlorophenyl


401
CH(CH3)2
4-chlorophenyl


402
CH(CH3)2
2-fluorophenyl


403
CH(CH3)2
3-fluorophenyl


404
CH(CH3)2
4-fluorophenyl


405
CH(CH3)2
2-methylphenyl


406
CH(CH3)2
3-methylphenyl


407
CH(CH3)2
4-methylphenyl


408
CH(CH3)2
2-methoxyphenyl


409
CH(CH3)2
3-methoxyphenyl


410
CH(CH3)2
4-methoxyphenyl


411
CH(CH3)2
2-(methoxycarbonyl)phenyl


412
CH(CH3)2
3-(methoxycarbonyl)phenyl


413
CH(CH3)2
4-(methoxycarbonyl)phenyl


414
CH(CH3)2
2-nitrophenyl


415
CH(CH3)2
3-nitrophenyl


416
CH(CH3)2
4-nitrophenyl


417
CH(CH3)2
2-(dimethylamino)phenyl


418
CH(CH3)2
3-(dimethylamino)phenyl


419
CH(CH3)2
4-(dimethylamino)phenyl


420
CH(CH3)2
2-(trifluoromethyl)phenyl


421
CH(CH3)2
3-(trifluoromethyl)phenyl


422
CH(CH3)2
4-(trifluoromethyl)phenyl


423
CH(CH3)2
3-(phenoxy)phenyl


424
CH(CH3)2
4-(phenoxy)phenyl


425
CH(CH3)2
2,4-difluorophenyl


426
CH(CH3)2
2,4-dichlorophenyl


427
CH(CH3)2
3,4-difluorophenyl


428
CH(CH3)2
3,4-dichlorophenyl


429
CH(CH3)2
3,5-difluorophenyl


430
CH(CH3)2
3,5-dichlorophenyl


431
CH(CH3)2
2-pyridyl


432
CH(CH3)2
3-pyridyl


433
CH(CH3)2
4-pyridyl


434
CH(CH3)2
α-naphthyl


435
CH(CH3)2
benzyl


436
CH(CH3)2
2-chlorobenzyl


437
CH(CH3)2
3-chlorobenzyl


438
CH(CH3)2
4-chlorobenzyl


439
CH(CH3)2
2-methoxybenzyl


440
CH(CH3)2
3-methoxybenzyl


441
CH(CH3)2
4-methoxybenzyl








442
—(CH2)4—


443
—CH2—CH═CH—CH2—









444
H
cyclohexyl


445
CH3
cyclohexyl


446
C2H5
cyclohexyl


447
n-C3H7
cyclohexyl


448
i-C3H7
cyclohexyl


449
n-C4H9
cyclohexyl


450
i-C4H9
cyclohexyl


451
sec-C4H9
cyclohexyl


452
tert-C4H9
cyclohexyl


453
H
CH2—CH═CH—CH3


454
CH3
CH2—CH═CH—CH3


455
C2H5
CH2—CH═CH—CH3


456
n-C3H7
CH2—CH═CH—CH3


457
i-C3H7
CH2—CH═CH—CH3


458
n-C4H9
CH2—CH═CH—CH3


459
i-C4H9
CH2—CH═CH—CH3


460
sec-C4H9
CH2—CH═CH—CH3


461
tert-C4H9
CH2—CH═CH—CH3


462
H
CH3S—CH2CH2


463
CH3
CH3S—CH2CH2


464
C2H5
CH3S—CH2CH3


465
n-C3H7
CH3S—CH2CH2


466
i-C3N7
CH3S—CH2CH3


467
n-C4H9
CH3S—CH2CH2


468
i-C4H9
CH3S—CH2CH2


469
sec-C4H9
CH3S—CH2CH2


470
tert-C4H9
CH3S—CH2CH2


471
H
C2H5—O—CH2CH2


472
CH3
C2H5—O—CH2CH2


473
C2H5
C2H5—O—CH2CH2


474
n-C3H7
C2H5—O—CH2CH2


475
i-C3H7
C2H5—O—CH2CH2


476
n-C4H9
C2H5—O—CH2CH2


477
i-C4H9
C2H5—O—CH2CH2


478
sec-C4H9
C2H5—O—CH2CH2


479
tert-C4H9
C2H5—O—CH2CH2








480
CH2CH2—O—CH2CH2


481
CH2—CH═CH—CH2


482
CH═CH—CH2—CH2


483
CH2—CH2—CH2—CH2—CH2


484
CH2—CH2—O—CH(CH3)—CH2


485
CH2—CH2—O—CH2—CH(CH3)


486
CH2—CH2—N(CH3)—CH2—CH2


487
CH2—CH(CH3)—O—CH(CH3)—CH2


488
CH2—CH═CH—CH2—CH2


489
CH═CH—CH2—CH2—CH2


490
CH2—CH2—CH2—CH2—CH(CH3)


491
CH2—CH2—CH2—CH(CH3)—CH2


492
CH2—CH2—CH(CH3)—CH2—CH2


493
CH2—CH2—CH2—CH2—CH(CH2CH2Cl)


494
CH2—CH2—CH2—CH(CH2CH2Cl)—CH2


495
CH2—CH2—CH(CH2CH2Cl)—CH2—CH2









Very particular preference is given to the isocyanatobenzoylsulfamic acid amides of the formula IA.1-b (≡I where W=oxygen, Ar=Ar-1 where Ra=Cl and Rb=Rd=hydrogen and Rc=H, A=NR1R2), where R1, R2 have the meanings mentioned above, and in particular the meanings mentioned as being preferred. Examples of such compounds are the compounds IA.1-b.1 to IA.1-b.495 in which the variables R1, R2 together have the meanings given in one row of Table 1.




Very particular preference is given to the isocyanatobenzoylsulfamic acid amides of the formula IA.1-c (≡I where W=oxygen, Ar=Ar-1 where Ra=Cl and Rb=Rd=hydrogen and Rc=Cl, A=NR1R2), where R1, R2 have the meanings mentioned above, and in particular the meanings mentioned as being preferred. Examples of such compounds are the compounds IA.1-c.1 to IA.1-c.495 in which the variables R1, R2 together have the meanings given in one row of Table 1.




Very particular preference is given to the isocyanatobenzoylsulfamic acid amides of the formula IA.1-d (≡I where W=oxygen, Ar=Ar-1 where Ra=F and Rb=Rd=hydrogen and Rc=F, A=NR1R2), where R1, R2 have the meanings mentioned above, and in particular the meanings mentioned as being preferred. Examples of such compounds are the compounds IA.1-d.1 to IA.1-d.495 in which the variables R1, R2 together have the meanings given in one row of Table 1.




Very particular preference is given to the isocyanatobenzoylsulfamic acid amides of the formula IA.1-e (≡I where W=oxygen, Ar=Ar-1 where Ra=CN and Rb=Rd=hydrogen and Rc=F, A=NR1R2), where R1, R2 have the meanings mentioned above, and in particular the meanings mentioned as being preferred. Examples of such compounds are the compounds IA.1-e.1 to IA.1-e.495 in which the variables R1, R2 together have the meanings given in one row of Table 1.




Very particular preference is given to the isocyanatobenzoylsulfamic acid amides of the formula IA.1-f (≡I where W=oxygen, Ar=Ar-1 where Ra=CN and Rb=Rd=hydrogen and Rc=Cl, A=NR1R2), where R1, R2 have the meanings mentioned above, and in particular the meanings mentioned as being preferred. Examples of such compounds are the compounds IA.1-f.1 to IA.1-f.495 in which the variables R1, R2 together have the meanings given in one row of Table 1.




Very particular preference is given to the isothiocyanatobenzoylsulfamic acid amides of the formula IA.1-g (≡I where W=sulfur, Ar=Ar-1 where Ra=Cl and Rb=Rd=hydrogen and Rc=F, A=NR1R2), where R1, R2 have the meanings mentioned above, and in particular the meanings mentioned as being preferred. Examples of such compounds are the compounds IA.1-g.1 to IA.1-g.495 in which the variables R1, R2 together have the meanings given in one row of Table 1.




Very particular preference is given to the isothiocyanatobenzoylsulfamic acid amides of the formula IA.1-h (≡I where W=sulfur, Ar=Ar-1 where Ra=Cl and Rb=Rd=hydrogen and Rc=H, A=NR1R2), where R1, R2 have the meanings mentioned above, and in particular the meanings mentioned as being preferred. Examples of such compounds are the compounds IA.1-h.1 to IA.1-h.495 in which the variables R1, R2 together have the meanings given in one row of Table 1.




Very particular preference is given to the isothiocyanatobenzoylsulfamic acid amides of the formula IA.1-h (≡I where W=sulfur, Ar=Ar-1 where Ra=Cl and Rb=Rd=hydrogen and Rc=Cl, A=NR1R2), where R1, R2 have the meanings mentioned above, and in particular the meanings mentioned as being preferred. Examples of such compounds are the compounds IA.1-i.1 to IA.1-i.495 in which the variables R1, R2 together have the meanings given in one row of Table 1.




Very particular preference is given to the isothiocyanatobenzoylsulfamic acid amides of the formula IA.1-j (≡I where W=sulfur, Ar=Ar-1 where Ra=F and Rb=Rd=hydrogen and Rc=F, A=NR1R2), where R1, R2 have the meanings mentioned above, and in particular the meanings mentioned as being preferred. Examples of such compounds are the compounds IA.1-j.1 to IA.1-j.495 in which the variables R1, R2 together have the meanings given in one row of Table 1.




Very particular preference is given to the isothiocyanatobenzoylsulfamic acid amides of the formula IA.1-k (≡I where W=sulfur, Ar=Ar-1 where Ra=CN and Rb=Rd=hydrogen and Rc=F, A=NR′R2), where R1, R2 have the meanings mentioned above, and in particular the meanings mentioned as being preferred. Examples of such compounds are the compounds IA.1-k.1 to IA.1-k.495 in which the variables R1, R2 together have the meanings given in one row of Table 1.




Very particular preference is given to the isothiocyanatobenzoylsulfamic acid amides of the formula IA.1-l (≡I where W=sulfur, Ar=Ar-1 where Ra=CN and Rb=Rd=hydrogen and Rc=Cl, A=NR1R2), where R1, R2 have the meanings mentioned above, and in particular the meanings mentioned as being preferred. Examples of such compounds are the compounds IA.1-1.1 to IA.1-1.495 in which the variables R1, R2 together have the meanings given in one row of Table 1.




In the process according to the invention, the starting materials used are aminobenzoylsulfamic acid amides of the formula II. These compounds are likewise novel and represent useful intermediates for preparing the iso(thio)cyanatobenzoylsulfamic acid amides I. With respect to the preparation process, reference is made to what has been said above.
Accordingly, the present invention also relates to the aniline compounds of the formula II, in particular to compounds of the formula IIA (≡II where Ar=Ar-1),




where Ra, Rb, Rc, Rd and A are as defined above. In the formula IIA, Ra, Rb, Rc, Rd and A preferably denote those radicals which have already been mentioned in connection with the description of the compounds I according to the invention as being preferred for these variables.

Particular preference is given to the compounds of the formula IIA.1,




in which the variables R1, R2, Ra, Rb, Rc, Rd are as defined above. In the formula IIA.1, the variables R1, R2, Ra, Rb, Rc, Rd preferably have those meanings which have already been mentioned in connection with the description of the compounds IA.1 according to the invention as being preferred.

Very particular preference is given to the aminobenzoylsulfamic acid amides of the formula IIA.1-a (≡II where Ar=Ar-1 where Ra=Cl and Rb=Rd=hydrogen and Rc=F, A=NR1R2), where R1, R2 have the meanings mentioned above, and in particular the meanings mentioned as being preferred. Examples of such compounds are the compounds IIA.1-a.1 to IIA.1-a.495 in which the variables R1, R2 together have the meanings given in one row of Table 1.




Very particular preference is given to the aminobenzoylsulfamic acid amides of the formula IIA.1-b (≡II where Ar=Ar-1 where Ra=Cl and Rb=Rd=hydrogen and Rc=H, A=NR1R2), where R1, R2 have the meanings mentioned above, and in particular the meanings mentioned as being preferred. Examples of such compounds are the compounds IIA.1-b.1 to IIA.1-b.495 in which the variables R1, R2 together have the meanings given in one row of Table 1.




Very particular preference is given to the aminobenzoylsulfamic acid amides of the formula IIA.1-c (≡II where Ar=Ar-1 where Ra=Cl and Rb=Rd=hydrogen and Rc=Cl, A=NR1R2), where R1, R2 have the meanings mentioned above, and in particular the meanings mentioned as being preferred. Examples of such compounds are the compounds IIA.1-c.1 to IIA.1-c.495 in which the variables R1, R2 together have the meanings given in one row of Table 1.




Very particular preference is given to the aminobenzoylsulfamic acid amides of the formula IIA.1-d (≡II where Ar=Ar-1 where Ra=F and Rb=Rd=hydrogen and Rc=F, A=NR1R2), where R1, R2 have the meanings mentioned above, and in particular the meanings mentioned as being preferred. Examples of such compounds are the compounds IIA.1-d.1 to IIA.1-d.495 in which the variables R1, R2 together have the meanings given in one row of Table 1.




Very particular preference is given to the aminobenzoylsulfamic acid amides of the formula IIA.1-e (≡II where Ar=Ar-1 where Ra=CN and Rb=Rd=hydrogen and Rc=F, A=NR1R2), where R1, R2 have the meanings mentioned above, and in particular the meanings mentioned as being preferred. Examples of such compounds are the compounds IIA.1-e.1 to IIA.1-e.495 in which the variables R1, R2 together have the meanings given in one row of Table 1.




Very particular preference is given to the aminobenzoylsulfamic acid amides of the formula IIA.1-f (≡II where Ar=Ar-1 where Ra=CN and Rb=Rd=hydrogen and Rc=Cl, A=NR1R2), where R1, R2 have the meanings mentioned above, and in particular the meanings mentioned as being preferred. Examples of such compounds are the compounds IIA.1-f.1 to IIA.1-f.495 in which the variables R1, R2 together have the meanings given in one row of Table 1.




The nitrobenzoylsulfamic acid amides of the formula V are likewise novel and also represent useful intermediates for preparing the iso(thio)cyanatobenzoylsulfamic acid amides I. They also form part of the subject-matter of the present invention.
Accordingly, the present invention also relates to the nitro compounds of the formula V, in particular to compounds of the formula VA (≡V where Ar=Ar-1),




where Ra, Rb, Rc, Rd and A are as defined above. In the formula VA, Ra, Rb, Rc, Rd and A preferably denote those radicals which have already been mentioned in connection with the description of the compound I according to the invention as being preferred for these variables.

Very particular preference is given to the compounds of the formula VA.1,




in which the variables R1, R2, Ra, Rb, Rc, Rd are as defined above. In the formula VA.1, the variables R1, R2, Ra, Rb, Rc, Rd preferably have those meanings which have already been mentioned in connection with the description of the compounds IA.1 according to the invention as being preferred.

Very particular preference is given to the nitrobenzoylsulfamic acid amides of the formula VA.1-a (≡V where Ar=Ar-1 where Ra=Cl and Rb=Rd=hydrogen and Rc=F, A=NR1R2), where R1, R2 have the meanings mentioned above, and in particular the meanings mentioned as being preferred. Examples of such compounds are the compounds VA.1-a.1 to VA.1-a.495 in which the variables R1, R2 together have the meanings given in one row of Table 1.




Very particular preference is given to the nitrobenzoylsulfamic acid amides of the formula VA.1-b (≡V where Ar=Ar-1 where Ra=Cl and Rb=Rd=hydrogen and Rc=H, A=NR1R2), where R1, R2 have the meanings mentioned above, and in particular the meanings mentioned as being preferred. Examples of such compounds are the compounds VA.1-b.1 to VA.1-b.495 in which the variables R1, R2 together have the meanings given in one row of Table 1.




Very particular preference is given to the nitrobenzoylsulfamic acid amides of the formula VA.1-c (≡V where Ar=Ar-1 where Ra=Cl and Rb=Rd=hydrogen and Rc=Cl, A=NR1R2), where R1, R2 have the meanings mentioned above, and in particular the meanings mentioned as being preferred. Examples of such compounds are the compounds VA.1-c.1 to VA.1-c.495 in which the variables R1, R2 together have the meanings given in one row of Table 1.




Very particular preference is given to the nitrobenzoylsulfamic acid amides of the formula VA.1-d (≡V where Ar=Ar-1 where Ra=F and Rb=Rd=hydrogen and Rc=F, A=NR1R2), where R1, R2 have the meanings mentioned above, and in particular the meanings mentioned as being preferred. Examples of such compounds are the compounds VA.1-d.1 to VA.1-d.495 in which the variables R1, R2 together have the meanings given in one row of Table 1.




Very particular preference is given to the nitrobenzoylsulfamic acid amides of the formula VA.1-e (≡V where Ar=Ar-1 where Ra=CN and Rb=Rd=hydrogen and Rc=F, A=NR1R2), where R1, R2 have the meanings mentioned above, and in particular the meanings mentioned as being preferred. Examples of such compounds are the compounds VA.1-e.1 to VA.1-e.495 in which the variables R1, R2 together have the meanings given in one row of Table 1.




Very particular preference is given to the nitrobenzoylsulfamic acid amides of the formula VA.1-f (≡V where Ar=Ar-1 where Ra=CN and Rb=Rd=hydrogen and Rc=Cl, A=NR1R2) where R1, R2 have the meanings mentioned above, and in particular the meanings mentioned as being preferred. Examples of such compounds are the compounds VA.1-f.1 to VA.1-f.495 in which the variables R1, R2 together have the meanings given in one row of Table 1.




The bifunctional phenyl iso(thio)cyanates Y according to the invention can be used as starting materials for pharmacologically active compounds or crop protection agents. WO 01/83459, for example, describes herbicidal 3-(triazolidinedione)-substituted benzoic acid sulfamoyl amides of the formula below




where X1 is hydrogen, halogen, C1-C4-alkyl, X2 is hydrogen, CN, CS—NH2, halogen, C1-C4-alkyl, C1-C4-haloalkyl, R11 and R21 have the meanings given above for R1 and R2, respectively, and are in particular hydrogen, unsubstituted or substituted hydroxyl, C1-C10-alkyl, C2-C10-alkenyl, C3-C10-alkynyl, C3-C7-cycloalkyl, phenyl, benzyl or C5-C7-cycloalkenyl, or R11 and R21 together with the nitrogen atom to which they are attached form a 3- to 7-membered heterocyclic ring, and Q is a radical of the formula a





where W is as defined above, W′ is O or S and R3 and R4 independently of one another are one of the radicals below: hydrogen, cyano, amino, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-haloalkoxy, C3-C7-cycloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C3-C6-alkynyl, benzyl, OR5 (where R5 is hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C7-cycloalkyl, C2-C6-alkenyl, C3-C6-alkynyl, unsubstituted or substituted phenyl or unsubstituted or substituted benzyl), C1-C3-cyanoalkyl, or R3 and R4 together with the nitrogen atoms to which they are attached form a four- to seven-membered heterocycle which is optionally interrupted by sulfur, oxygen, a group NR6 (where R6 is as defined above) or nitrogen and which is unsubstituted or mono- or polysubstituted by halogen or C1-C4-alkyl, and is in particular a radical of the formula b:





where W is as defined above and W′ and Z independently of one another are oxygen or sulfur.

The herbicides described in WO 01/83459 are not always obtainable in sufficient yields and purity. The processes described therein are based, for example:

    A) on the condensation of a substituted benzoic acid with a substituted sulfamic acid amide in the presence of N,N-carbonyldiimidazole (CDI) or the conversion of the carboxylic acid into its acid chloride and subsequent reaction of the acid chloride with the sulfamic acid amide.






Here, the variables R11, R21, X1 and X2 may have the meanings mentioned above, and Q is a 5- or 6-membered heterocycle, for example a radical a or b.
This process has the disadvantage that the benzoic acid used can only be obtained from the ester precursor by cleavage with boron tribromide, with the corresponding amount of salt being produced. Moreover, the yield of the condensation with sulfamic acid amides is only from 16 to 45%. Even the detour via an acid chloride, prepared beforehand, gives the desired benzoylsulfamic acid amide in a yield of only 26%, and in addition, its impurities have to be removed chromatographically.

    B) The substitution of a halogen radical by the heterocyclic radical Q:






Here, the variables R11, R21, X1 and X2 may have the meanings mentioned above, Hal is fluorine, chlorine or bromine and Q is a 5- or 6-membered heterocycle, for example a radical a or b.
This process has the disadvantages that the halogenated aromatic compound used has to be provided in a complicated manner via a Sandmeyer reaction, and moreover an unsatisfactory selectivity in the reaction of the 5-halo-substituted compound, compared to the—activated—2,4-dihalosubstituents present in the same molecule.
Accordingly, all of the prior-art processes for preparing 3-(triazolidinedione)-substituted benzoylsulfamoylamides and their sulfur analogs are unsatisfactory with respect to a short reaction time, a simple practice of the reaction, yields and purity of the end products, and are therefore uneconomical.
Accordingly, it is another object of the present invention to provide a process for preparing compounds of the formula VI,




where W, Ar and A are as defined in claim 1, W′ is O or S and R3 and R4 independently of one another are hydrogen, cyano, amino, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-haloalkoxy, C3-C7-cycloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C3-C6-alkynyl, benzyl, OR5 (where R5 is hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C7-cycloalkyl, C2-C6-alkenyl, C3-C6-alkynyl, unsubstituted or substituted phenyl or unsubstituted or substituted benzyl), C1-C3-cyanoalkyl, or R3 and R4 together with the nitrogen atoms to which they are attached form a four- to seven-membered heterocycle which is optionally interrupted by sulfur, oxygen, a group NR6 (where R6 is as defined above) or nitrogen and which is unsubstituted or mono- or polysubstituted by halogen or C1-C4-alkyl.

Surprisingly, it has now been found that, starting with the compounds of the formula I according to the invention, in particular the compounds of the formula IA, it is possible to prepare the compounds of the formula VI described in WO 01/83459 in a much more simple manner, without side reactions and in higher yields and purity.
Accordingly, the present invention also provides a process for preparing compounds of the formula VI




where R3, R4, W, W′, Ar, A are as defined above

which comprises the following steps

    (i) reaction of a compound of the formula I as defined above with an oxadiazinecarboxylic acid ester of the formula VII,






    
    
        where W′ is as defined above and R′ is C1-C4-alkyl, giving a urea derivative of the formula VIII
    
    






    
    
        where the variables R3, R4, R′, W, W′, Ar and A are as defined above, and
    
    
    (ii) cyclization of the resulting intermediate VIII, giving a compound of the formula VI.


Step (i) is carried out in a manner known per se, for example as described in WO 02/20531. In general, the iso(thio)cyanate of the formula I according to the invention is added to a compound of the formula VII, preferably in a solvent. Suitable solvents are hydrocarbons, such as pentane, hexane, cyclopentane, cyclohexane, toluene, xylene; chlorinated hydrocarbons, such as methylene chloride, chloroform, 1,2-dichloroethane, 1,1,2,2-tetrachloroethane, chlorobenzene, 1,2-, 1,3- or 1,4-dichlorobenzene; ethers, such as 1,4-dioxane, anisole; glycol ethers, such as dimethyl glycol ether, diethyl glycol ether, diethylene glycol dimethyl ether; esters, such as ethyl acetate, propyl acetate, methyl isobutyrate, isobutyl acetate; carboxamides, such as N,N-dimethylformamide, N-methylpyrrolidone; nitrated hydrocarbons, such as nitrobenzene, nitriles, such as acetonitrile, propionitrile, butyronitrile or isobutyronitrile; or else mixtures of individual solvents. The addition is generally carried out over a period of from 5 to 30 minutes. During the addition, the temperature is usually from 10 to 25° C. To bring the reaction to completion, the mixture is stirred for another 0.5 to 24 hours at from 20 to 80° C. It is, of course, also possible to initially charge the iso(thio)cyanate I in one of the abovementioned solvents, to add the compound VII and then to bring the reaction to completion as described above. Usually, from 0.9 to 1.4 mol, preferably from 0.95 to 1.1 mol and particularly preferably from 0.98 to 1.15 mol of the compound VII are employed per mole of the compound I. The compound of the formula VII used in step (i) is known or can be prepared similarly to the process described in WO 02/20531.
Step (ii) is again carried out in a manner known per se, for example as described in WO 02/20531, by treating the compound of the formula VIII with a base.
Suitable bases are, in principle, all compounds capable of abstracting the acidic proton of the NH group of the urea function in the compounds of the formula VIII. These include oxo bases, nitrogen bases and hydride bases.
The oxo bases include, for example, inorganic bases, such as alkali metal or alkaline earth metal hydroxides, alkali metal or alkaline earth metal bicarbonates, and also alkali metal and alkaline earth metal carbonates, for example lithium hydroxide, bicarbonate or carbonate, sodium hydroxide, bicarbonate or carbonate, potassium hydroxide, bicarbonate or carbonate, calcium hydroxide, bicarbonate or carbonate, or magnesium hydroxide, bicarbonate or carbonate. Suitable oxo bases are likewise alkali metal alkoxides, in particular those of lithium, sodium or potassium, where, in general, alkoxides of C1-C6-, preferably C1-C4-alkanols, such as sodium methoxide, ethoxide, n-butoxide or tert-butoxide or potassium methoxide, ethoxide, n-butoxide or tert-butoxide are used. The nitrogen bases include primary, secondary or, preferably, tertiary amines, for example trialkylamines, such as triethylamine, tri-n-propylamine, N-ethyldiisopropylamine; cycloaliphatic amines, such as N,N-dimethylcyclohexylamine; cyclic amines, such as azabicyclo[2.2.2]octane (=triethylenediamine), N-methylpyrrolidine, N-ethylpiperidine; dialkylanilines, such as dimethylaminoaniline; p-dimethylaminopyridine; furthermore aromatic nitrogen heterocycles, such as pyridine, α-, β- or γ-picoline, 2,4- and 2,6-lutidine, quinoline, quinazoline, quinoxaline, pyrimidine; and also tertiary amides, for example dimethylformamide, N-methylformamide, N-methylpyrrolidone or tetramethylurea.
Suitable hydride bases are, for example, alkali metal hydrides, such as sodium hydride or potassium hydride. Preferred bases are tertiary amines, in particular trialkylamines.
Preference is given to using from 0.9 to 1.4 mol, in particular from 0.95 to 1.2 mol and with particular preference from 0.98 to 1.15 mol of the compound VIII per mole of base.
For the reaction of the compound VIII with the base, the compound VIII is preferably initially charged in one of the solvents mentioned above or in a solvent mixture, and the base is added with mixing, for example with stirring, to the reaction mixture. The addition of the base is preferably carried out at a temperature in the range from 0 to 50° C. and in particular from 10 to 30° C.
In general, the components are then allowed to react for another 10 minutes to 48 hours at from 20 to 150° C., preferably from 20 to 100° C. and in particular from 20 to 60° C., to bring the reaction to completion. In the case of thioureas of the formula VIII (W=S), the reaction is generally substantially complete (conversion >90%) after 0.5-10 hours, and in the case ureas of the formula VIII (W=O) after 4-48 hours and in particular after 8-24 hours. However, it is also possible to initially charge the base, preferably in one of the solvents mentioned above, followed by addition of the compound VIII and conclusion of the reaction as above.
The concentration of the starting materials in the solvent is generally in the range from 0.5 to 5 mol/l, preferably in the range from 0.2 to 2 mol/1.
Work-up of the reaction is carried out in a customary manner, for example by aqueous extraction, by dialysis and/or chromatographically.
The present process relates in particular to the preparation of compounds VIA




where R3 and R4 are as defined above and the variables W, W′, Ra, Rb, Rc, Rd, A have the meanings given above and in particular the meanings which have already been mentioned in connection with the description of compound IA as being preferred for these variables. In this case, the compound used in the process according to the invention for preparing the compound VIA is a compound of the formula IA, preferably a compound of the formula IA.1.

A preferred compound of the formula VII is, for example, a compound of the formula (VII′)




where Z is O or S and R′ is C1-C4-alkyl. This compound is known from WO 02/20531.

By this route, starting with the compounds of the formula IA, it is possible, in accordance with Scheme 3 below, to prepare in particular compounds of the formula IX (=compound VIA where Rb=Rd=H, A=NR1R2, W=W′=O and R3, R4 are CH2CH2OCH2).




Here, the variables Ra, Rc, R1 and R2 have the meanings mentioned above.
The process according to the invention is, with respect to yields and purity, superior to the process described in WO 01/83459. Moreover, its practice is much easier. With respect to the disadvantages of the process known from WO 01/83459, reference is made to what has been said above.
The examples below serve to illustrate the invention
I Preparation of the Nitrobenzoylsulfamic Acid Amides (Intermediate of the Formula VA.1; Intermediates VA.1-1 to VA.1-24)


EXAMPLE 1
N-(2-Chloro-4-fluoro-5-nitrobenzoyl)-N′-n-propyl-N′-allyl-sulfamide (VA.1-a.241)




At from −5° C. to 0° C., 11.62 g (0.0474 mol) of 2-chloro-4-fluoro-5-nitrobenzoyl chloride in 50 ml methylene chloride were added with stirring, over 30 minutes, to a mixture of 8.50 g (0.048 mol) of N′-propyl-N′-allylsulfamide, 10.38 g (0.103 mol) of triethylamine and 0.09 g (0.736 mmol) of 4-N,N-dimethylaminopyridine in 90 ml of methylene chloride. The funnel was rinsed with 10 ml of the solvent. The mixture was initially stirred at 0° C. for 1 hour and then at 22° C. for 2 hours. 50 ml of 1N hydrochloric acid were then added, the mixture was stirred and the phases were separated. The organic phase was washed two more times with 1N hydrochloric acid and the aqueous phase was extracted with methylene chloride. Drying of the organic phase over magnesium sulfate was followed by filtration and concentration of the solution. The residue was triturated with diethyl ether/pentane, filtered off with suction and dried, giving 18.41 g (91.9% of theory) of the title compound of melting point (m.p.) of 110-112° C.
The intermediates VA.1 (compounds of the formula VI where Ar=Ar-1 where Rb, Rd=H and R1 and R2 have the meanings given in Table 1) of Examples 2 to 24 listed in Table 2 were obtained in an analogous manner.







TABLE 2







(VA.1)








 

















m.p. [° C.]/







1H-NMR







(400 MHz,


Example/




CDCl3) δ


No.1)
Rc
Ra
R1
R2
(ppm)















1
F
Cl
n-C3H7
CH2═CH—CH2
110-112


VA.1-a.241
















2
F
Cl
CH2—CH2—CH(CH3)—CH2—CH2
137-138












VA.1-a.490







3
F
Cl
i-C3H7
HC≡C—CH2
160-161


VA.1-a.387
















4
H
Cl
CH2—CH2—CH(CH3)—CH2—CH2
151-152












VA.1-b.492







5
H
Cl
n-C3H7
CH2═CH—CH
132-134


VA.1-b.241







6
H
Cl
i-C3H7
HC≡C—CH2
138-140


VA.1-b.387







7
F
Cl
CH3
i-C3H7
121-122


VA.1-a.86







8
F
Cl
CH3
CH3



VA.1-a.76







9
F
Cl
CH3
C2H5



VA.1-a.77







10
F
Cl
CH3
n-C3H7



VA.1-a.84







11
F
Cl
CH3
c-C3H5



VA.1-a.98







12
F
Cl
CH3
n-C4H9



VA.1-a.85







13
F
Cl
CH3
i-C4H9



VA.1-a.88







14
F
Cl
CH3
sec-C4H9



VA.1-a.87







15
F
Cl
CH3
tert-C4H9



VA.1-a.89







16
F
Cl
CH3
CH2═CH—CH2



VA.1-a.93







17
F
Cl
CH3
HC≡C—CH2



VA.1-a.96







18
F
Cl
CH3
C6H5



VA.1-a.107







19
F
Cl
CH3
cyclohexyl



VA.1-a.445







20
F
Cl
C2H5
C6H5



VA.1-a.181







21
F
Cl
C2H5
cyclohexyl



VA.1-a.446







22
F
Cl
C2H5
i-C3H7



VA.1-a.160







23
F
Cl
C2H5
CH2═CH—CH2



VA.1-a.167







24
H
Cl
CH3
sec. -C4H9
8.4 (d,


VA.1.-b.87




1H), 8.2







(m, 1H),







7.6 (d,







1H), 4.0







(sept.,







1H), 2.9







(s, 3H),







1.5 (m,







2H), 1.2







(d, 6H),







0.9 (t,







3H).









1) Compound Number According to Table 1
II Preparation of the Aminobenzoylsulfamic Acid Amides of the Formula IIA (Intermediates IIA.1)
IIa Reduction of the Nitro Group Using Iron Powder in Acetic Acid
EXAMPLE 25
N-(5-Amino-2-chloro-4-fluorobenzoyl)-N′-allyl-N′-n-propylsulfamide (IIA.1-a.241)




With stirring, a solution of 17.1 g (45.02 mmol) of the compound VA.1-a.241 from Example 1 in a mixture of 5 ml of tetrahydrofuran and 40 ml of acetic acid was added at 70 to 75° C. over a period of 25 minutes to a suspension of 7.54 g (135.072 mmol) of iron powder in 60 ml of acetic acid. The mixture was stirred at 70 to 75° C. for another hour and then allowed to cool and concentrated under reduced pressure. The residue was stirred with ethyl acetate and filtered, and the precipitate was washed with ethyl acetate. The filtrate was stirred with activated carbon and magnesium sulfate, filtered, washed and concentrated. The residue was turned into a paste using ethyl acetate, triturated with pentane, filtered off with suction and dried, giving 12.1 g (75.3% of theory) of the title compound of melting point 104-106° C.
IIb Catalytic Hydrogenation of the Nitro Group
EXAMPLE 31
N-(5-Amino-2-chloro-4-fluorobenzoyl)-N′-methyl-N′-isopropylsulfamide (IIA.1-a.86)




112.0 g (0.317 mol) of the compound VA.1-a.86 from Example 7 and 100 g of Raney nickel in 1200 ml of methanol were initially charged in a hydrogenation apparatus. With stirring, the apparatus was flushed with 10 l of nitrogen and with 10 l of hydrogen. With stirring, the mixture was hydrogenated at 22-23° C. using a hydrogen pressure of 0.1 bar. In total, 21.3 l of hydrogen were taken up. The mixture was vented and again flushed with 10 l of nitrogen. The reaction mixture was filtered off with suction through silica gel and the filtrate was concentrated under reduced pressure. This gave 100.5 g (97% of theory) of the title compound of melting point 160-162° C. (purity according to HPLC: 99.1%).
Starting with the nitrobenzoylsulfamic acid amides VA.1 listed in Table 2, the intermediates IIA (compounds of the formula II where Ar=Ar-1 where Rb, Rd=H and R1 and R2 have the meanings given in Table 1) of Example 26 to Example 48 listed in Table 3 were obtained in an analogous manner.








TABLE 3








IIA.1













 

















m.p.







[° C.]/







1H-NMR







(400 MHz,


Example/




CDCl3) δ


No.1)
Rc
Ra
R1
R2
(ppm)















25
F
Cl
n-C3H7
CH2═CH—CH2
104-106


IIA.1-a.241
















26
F
Cl
CH2—CH2—CH(CH3)—CH2—CH2
144-145












IIA.1-a.492







27
F
Cl
i-C3H7
HC≡C—CH2
153-154


IIA.1-a.387
















28
H
Cl
CH2—CH2—CH(CH3)—CH2—CH2
139












IIA.1-b.492







29
H
Cl
n-C3H7
CH2═CH—CH2
138


IIA.1-b.241







30
H
Cl
i-C3H7
HC≡C—CH2
139-140


IIA.1-b.387







31
F
Cl
CH3
i-C3H7
160-162


IIA.1-a.86







32
F
Cl
CH3
CH3



IIA.1-a.76







33
F
Cl
CH3
C2H5



IIA.1-a.77







34
F
Cl
CH3
n-C3H7



IIA.1-a.84







35
F
Cl
CH3
c-C3H5



IIA.1-a.98







36
F
Cl
CH3
n-C4H9



IIA.1-a.85







37
F
Cl
CH3
i-C4H9



IIA.1-a.88







38
F
Cl
CH3
sek.-C4H9



IIA.1-a.87







39
F
Cl
CH3
tert.-C4H9



IIA.1-a.89







40
F
Cl
CH3
CH2═CH—CH2



IIA.1-a.93







41
F
Cl
CH3
HC≡C—CH2



IIA.1-a.96







42
F
Cl
CH3
C6H5



IIA.1-a.107







43
F
Cl
CH3
Cyclohexyl



IIA.1-a.445







44
F
Cl
C2H5
C6H5



IIA.1-a.181







45
F
Cl
C2H5
Cyclohexyl



IIA.1-a.446







46
F
Cl
C2H5
i-C3H7



IIA.1-a.160







47
F
Cl
C2H5
CH2═CH—CH2



IIA.1-a.167







48
H
Cl
CH3
sek.-C4H9
8.8 (br.


IIA.1-b.87




s), 7.2







(d, 1H),







7.1 (m,







1H), 6.8







(d, 1H),







4.0 (m,







1H), 3.8







(br. s,







2H), 2.9







(s, 3H),







1.6-1.4 (m,







2H), 1.2







(d, 3H),







0.9 (t,







3H)









1) Compound Number According to Table 1
III Preparation of the Phenyl Iso(thio)cyanates I
EXAMPLE 109
N-(2-Chloro-4-fluoro-5-isocyanatobenzoyl)-N′-allyl-N′-n-propyl-sulfamide (IA.1-a.241)




With stirring at 15 to 25° C., 4.7 ml of a 4 M solution of HCl in dioxane (corresponds to 18.9 mmol of hydrogen chloride) was added to 6.0 g (17.2 mmol) of the compound IIA.1-a.241 from Example 25 in 50 ml of dioxane. The mixture was stirred at 22° C. for another hour. With stirring and slowly increasing the temperature to 95° C., 3.4 g (34.3 mmol) of phosgene were introduced over a period of 1 h. Unreacted phosgene was flushed out with nitrogen. The reaction mixture was then concentrated under reduced pressure, the residue was triturated with pentane and the supernatant was decanted off and concentrated under reduced pressure. This gave 6.5 g (95.8% of theory, purity according to 1H-NMR: 95%) of the title compound of melting point 85-95° C. (decomp.).
IR (KBr): N═C═O 2265 cm−1; C═O 1724 cm−1.
EXAMPLE 94
N-(2-Chloro-4-fluoro-5-isocyanatobenzoyl)-N′-methyl-N′-isopropyl-sulfamide (IA.1-a.86)




A) By Reaction with Phosgene

At 22° C. and with stirring, phosgene was introduced into a solution of 5.0 g (15.4 mmol) of the compound IIA.1-a.86 from Example 31 in 50 ml of dioxane. Over a period of 20 minutes, the temperature was increased to the reflux temperature of the solvent mixture. Phosgene was introduced for another hour and the mixture was then allowed to cool to room temperature and flushed with nitrogen. The reaction mixture was then concentrated under reduced pressure, initially at 22° C. and then at 70° C. The residue was triturated with n-hexane, the n-hexane was decanted and the residue was dried at 70° C., giving 5.5 g (99.8% of theory of a 1H-NMR purity of 98%) of the title compound of melting point 146-149° C.
B) By Reaction with Diphosgene
With stirring at 10° C., 6.11 g (30.9 mmol) of diphosgene were added dropwise to a solution of 5.0 g (15.4 mmol) of the compound IIA.1-a.86 in 50 ml of dioxane. The reaction mixture was allowed to warm to 22° C., and stirring was continued for a further 1.5 hours. According to thin-layer chromatography, the reaction was then complete. The mixture was stirred overnight and then flushed with nitrogen and worked-up as described above in Example 94A. This gave 5.5 g (99.8% of theory of a 1H-NMR purity of 98%) of the title compound of melting point 148-150° C.
EXAMPLE 118
N-(2-Chloro-4-fluoro-5-isocyanatobenzoyl)-N-(4-methylpiperidine-sulfonamide) (IA.1-a.492)




With stirring at 20 to 25° C., 2.6 ml of a 4 M HCl solution (corresponds to 0.38 g (10.3 mmol) of hydrogen chloride) in dioxane were added to 1.8 g (5.1 mmol) of the compound IIA.1-a.492 from Example 26 in 50 ml of dioxane. The mixture was stirred at 22° C. for another hour. A further 1.12 g (5.66 mmol) of diphosgene were then added with stirring, and the mixture was stirred at 22° C. for 30 min., heated slowly to 95° C. and stirred for another hour. After cooling to room temperature, the mixture was concentrated under reduced pressure, the residue was triturated with pentane, the supernatant solution was decanted and the solution was reconcentrated under reduced pressure. This gave 2.0 g (98.3% of theory, of a 1H-NMR purity 95%) of the title compound of melting point 122-124° C. (decomp.), 135° C. clear.
IR (KBr): N═C═O 2246 cm−1; C═O 1697 cm−1.
EXAMPLE 193
N-(2-Chloro-4-fluoro-5-isothiocyanatobenzoyl)-N′-allyl-N′-n-propyl-sulfamide (IA.1-g.241)




With stirring at 22° C., 1.1 g (9.4 mmol) of thiophosgene were added to 3.0 g (8.6 mmol) of the compound IIA.1-a.241 from Example 25 in 50 ml of ethyl acetate, and the mixture was then stirred for another hour and then heated at 75° C. and stirred for another hour. After concentration under reduced pressure, the residue was triturated with pentane, filtered off with suction and dried, giving 3.4 g (96.1% of theory, purity according to 1H-NMR 95%) of the title compound of melting point 83-85° C.
IR (KBr): N═C═S 2030 cm−1, C═O 1725 cm−1.
Starting with the aminobenzoylsulfamic acid amides IA.1 listed in Table 3, the title compounds IA.1 (compounds of the formula I where Ar=Ar-1 where Rb, Rd=H and R1 and R2 have the meanings given in Table 1) of Example 49 to Example 216 listed in Table 4 were obtained in an analogous manner.








TABLE 4








(IA.1)













 



















m.p. 


Ex.
W
Rc
Ra
R1
R2
[° C.]
















49
O
H
Cl
CH3
CH3



50
O
H
Cl
CH3
C2H5



51
O
H
Cl
CH3
n-C3H7



52
O
H
Cl
CH3
i-C3H7



53
O
H
Cl
CH3
c-C3H5



54
O
H
Cl
CH3
n-C4H9



55
O
H
Cl
CH3
i-C4H9



56
O
H
Cl
CH3
sec.-C4H9



57
O
H
Cl
CH3
tert.-C4H9



58
O
H
Cl
C2H5
C2H5



59
O
H
Cl
C2H5
n-C3H7



60
O
H
Cl
C2H5
i-C3H7



61
O
H
Cl
C2H5
c-C3H5



62
O
H
Cl
C2H5
n-C4H9



63
O
H
Cl
C2H5
i-C4H9



64
O
H
Cl
C2H5
sec.-C4H9



65
O
H
Cl
CH2═CH—CH2
CH3



66
O
H
Cl
CH2═CH—CH2
C2H5



67
O
H
Cl
CH2═CH—CH2
n-C3H7
102-104








(Zers.)


68
O
H
Cl
CH2═CH—CH2
i-C3H7



69
O
H
Cl
CH2═CH—CH2
n-C4H9



70
O
H
Cl
CH2═CH—CH2
sec.-C4H9



71
O
H
Cl
HC≡C—CH2
CH3



72
O
H
Cl
HC≡C—CH2
C2H5



73
O
H
Cl
HC≡C—CH2
n-C3H7



74
O
H
Cl
HC≡C—CH2
i-C3H7
133-141








(Zers.)


75
O
H
Cl
HC≡C—CH2
n-C4H9













76
O
H
Cl
CH2—CH2—CH(CH3)—CH2—CH2
110-115



















(Zers.)


77
O
H
Cl
CH3
cyclohexyl



78
O
H
Cl
CH3
C6H5



79
O
H
Cl
C2H5
cyclohexyl



80
O
H
Cl
C2H5
C6H5













81
O
H
Cl
[CH2]4



82
O
H
Cl
[CH2]5














83
O
H
CN
CH3
CH3



84
O
H
CN
CH3
C2H5



85
O
H
CN
CH3
i-C3H7



86
O
H
CN
CH3
n-C3H7



87
O
H
CN
CH3
i-C4H9



88
O
H
CN
CH3
sec.-C4H9



89
O
H
CN
CH3
cyclohexyl



90
O
H
CN
CH3
C6H5



91
O
F
Cl
CH3
CH3



92
O
F
Cl
CH3
C2H5



93
O
F
Cl
CH3
n-C3H7



94
O
F
Cl
CH3
i-C3H7
144-148


95
O
F
Cl
CH3
c-C3H5



96
O
F
Cl
CH3
n-C4H9



97
O
F
Cl
CH3
i-C4H9



98
O
F
Cl
CH3
sec.-C4H9



99
O
F
Cl
CH3
tert.-C4H9



100
O
F
Cl
C2H5
C2H5



101
O
F
Cl
C2H5
n-C3H7



102
O
F
Cl
C2H5
i-C3H7



103
O
F
Cl
C2H5
c-C3H5



104
O
F
Cl
C2H5
n-C4H9



105
O
F
Cl
C2H5
i-C4H9



106
O
F
Cl
C2H5
sec.-C4H9



107
O
F
Cl
CH2═CH—CH2
CH3



108
O
F
Cl
CH2═CH—CH2
C2H5



109
O
F
Cl
CH2═CH—CH2
n-C3H7
85-95








(Zers.)


110
O
F
Cl
CH2═CH—CH2
i-C3H7



111
O
F
Cl
CH2═CH—CH2
n-C4H9



112
O
F
Cl
CH2═CH—CH2
sec.-C4H9



113
O
F
Cl
HC≡C—CH2
CH3



114
O
F
Cl
HC≡C—CH2
C2H5



115
O
F
Cl
HC≡C—CH2
n-C3H7



116
O
F
Cl
HC≡C—CH2
i-C3H7
124-126








(Zers.)


117
O
F
Cl
HC≡C—CH2
n-C4H9













118
O
F
Cl
CH2—CH2—CH(CH3)—CH2—CH2
122-124



















(Zers.)


119
O
F
Cl
CH3
cyclohexyl



120
O
F
Cl
CH3
C6H5



121
O
F
Cl
C2H5
cyclohexyl



122
O
F
Cl
C2H5
C6H5













123
O
F
Cl
[CH2]4



124
O
F
Cl
[CH2]5














125
O
F
CN
CH3
CH3



126
O
F
CN
CH3
C2H5



127
O
F
CN
CH3
i-C3H7



128
O
F
CN
CH3
n-C3H7



129
O
F
CN
CH3
i-C4H9



130
O
F
CN
CH3
sec.-C4H9



131
O
F
CN
CH3
cyclohexyl



132
O
F
CN
CH3
C6H5



133
S
H
Cl
CH3
CH3



134
S
H
Cl
CH3
C2H5



135
S
H
Cl
CH3
n-C3H7



136
S
H
Cl
CH3
i-C3H7



137
S
H
Cl
CH3
c-C3H5



138
S
H
Cl
CH3
n-C4H9



139
S
H
Cl
CH3
i-C4H9



140
S
H
Cl
CH3
sec.-C4H9



141
S
H
Cl
CH3
tert.-C4H9



142
S
H
Cl
C2H5
C2H5



143
S
H
Cl
C2H5
n-C3H7



144
S
H
Cl
C2H5
i-C3H7



145
S
H
Cl
C2H5
c-C3H5



146
S
H
Cl
C2H5
n-C4H9



147
S
H
Cl
C2H5
i-C4H9



148
S
H
Cl
C2H5
sec.-C4H9



149
S
H
Cl
CH2═CH—CH2
CH3



150
S
H
Cl
CH2═CH—CH2
C2H5



151
S
H
Cl
CH2═CH—CH2
n-C3H7
 99-100


152
S
H
Cl
CH2═CH—CH2
i-C3H7



153
S
H
Cl
CH2═CH—CH2
n-C4H9



154
S
H
Cl
CH2═CH—CH2
sec.-C4H9



155
S
H
Cl
HC≡C—CH2
CH3



156
S
H
Cl
HC≡C—CH2
C2H5



157
S
H
Cl
HC≡C—CH2
n-C3H7



158
S
H
Cl
HC≡C—CH2
i-C3H7
163-164


159
S
H
Cl
HC≡C—CH2
n-C4H9













160
S
H
Cl
CH2—CH2—CH(CH3)—CH2—CH2
143-144













161
S
H
Cl
CH3
cyclohexyl



162
S
H
Cl
CH3
C6H5



163
S
H
Cl
C2H5
cyclohexyl



164
S
H
Cl
C2H5
C6H5













165
S
H
Cl
[CH2]4



166
S
H
Cl
[CH2]5














167
S
H
CN
CH3
CH3



168
S
H
CN
CH3
C2H5



169
S
H
CN
CH3
i-C3H7



170
S
H
CN
CH3
n-C3H7



171
S
H
CN
CH3
i-C4H9



172
S
H
CN
CH3
sec.-C4H9



173
S
H
CN
CH3
cyclohexyl



174
S
H
CN
CH3
C6H5



175
S
F
Cl
CH3
CH3



176
S
F
Cl
CH3
C2H5



177
S
F
Cl
CH3
n-C3H7



178
S
F
Cl
CH3
i-C3H7



179
S
F
Cl
CH3
c-C3H5



180
S
F
Cl
CH3
n-C4H9



181
S
F
Cl
CH3
i-C4H9



182
S
F
Cl
CH3
sec.-C4H9



183
S
F
Cl
CH3
tert.-C4H9



184
S
F
Cl
C2H5
C2H5



185
S
F
Cl
C2H5
n-C3H7



186
S
F
Cl
C2H5
i-C3H7



187
S
F
Cl
C2H5
c-C3H5



188
S
F
Cl
C2H5
n-C4H9



189
S
F
Cl
C2H5
i-C4H9



190
S
F
Cl
C2H5
sec.-C4H9 



191
S
F
Cl
CH2═CH—CH2
CH3



192
S
F
Cl
CH2═CH—CH2
C2H5



193
S
F
Cl
CH2═CH—CH2
n-C3H7
83-85


194
S
F
Cl
CH2═CH—CH2
i-C3H7



195
S
F
Cl
CH2═CH—CH2
n-C4H9



196
S
F
Cl
CH2═CH—CH2
sec.-C4H9



197
S
F
Cl
HC≡C—CH2
CH3



198
S
F
Cl
HC≡C—CH2
C2H5



199
S
F
Cl
HC≡C—CH2
n-C3H7



200
S
F
Cl
HC≡C—CH2
i-C3H7
155-156


201
S
F
Cl
HC≡C—CH2
n-C4H9













202
S
F
Cl
CH2—CH2—CH(CH3)—CH2—CH2
152-153













203
S
F
Cl
CH3
cyclohexyl



204
S
F
Cl
CH3
C6H5



205
S
F
Cl
C2H5
cyclohexyl



206
S
F
Cl
C2H5
C6H5













207
S
F
Cl
[CH2]4



208
S
F
Cl
[CH2]5














209
S
F
CN
CH3
CH3



210
S
F
CN
CH3
C2H5



211
S
F
CN
CH3
i-C3H7



212
S
F
CN
CH3
n-C3H7



213
S
F
CN
CH3
i-C4H9



214
S
F
CN
CH3
sec.-C4H9 



215
S
F
CN
CH3
cyclohexyl



216
S
F
CN
CH3
C6H5









EXAMPLE 217
8-(5′-N-Isopropyl-N-methylsulfamoyl-carboxamido-4′-chloro-2′-fluorophenyl)-4-oxo-7,9-dioxo-1,2,8-triaza[4.3.0]nonane (Example 146 of WO 01/83459)
217.1: Methyl tetrahydro-N-(4-chloro-2-fluoro-5-N-isopropyl-N-methylsulfamoylcarboxamidophenyl)-4H-1,3,4-oxadiazine-3-carboxamide-4-carboxylate
Over a period of 5 minutes, 9.8 g (10.1 mmol) of methyl tetrahydro-4H-1,3,4-oxadiazine-4-carboxylate, as a 15% strength solution in 1,2-dichloroethane, were added at 22° C. and with stirring to a mixture of 3.5 g (10.1 mmol) of N-(2-chloro-4-fluoro-5-isocyanatobenzoyl)-N′-isopropyl-N′-methylsulfamide IA-a.86 from Example 94 in 100 ml of 1,2-dichloroethane, and the mixture was stirred for 18 hours. The reaction mixture was then purified by flash chromatography on silica gel using 200 ml portions of a mixture of methylene chloride/diethyl ether=1:6 as mobile phase. The solvent was removed under reduced pressure, giving 4.3 g (82.3% of theory) of methyl tetrahydro-N-(4-chloro-2-fluoro-5-N-isopropyl-N-methylsulfamoylcarboxamidophenyl)-4H-1,3,4-oxadiazine-3-carboxamide-4-carboxylate of melting point 69° C. (decomposition).
217.2: 8-(5′-N-Isopropyl-N-methylsulfamoylcarboxamido-4′-chloro-1-2′-fluorophenyl)-4-oxo-7,9-dioxo-1,2,8-triaza[4.3.0]nonane
In a reaction vessel fitted with stirrer and water separator, 0.85 g (1.7 mmol) of the compound from Example 217.1 was initially charged in 80 ml of toluene. With stirring, 0.18 g (1.8 mmol) of 97% pure sodium tert-butoxide was added at 22° C., and the mixture was then heated to reflux with stirring. The toluene was occasionally replaced. In total, the mixture was heated at reflux for 7 hours until the reaction mixture became more highly liquid and the solids were almost completely dissolved. After cooling, the reaction mixture was acidified using a 1M solution of HCl in 10 ml of diethyl ether and concentrated under reduced pressure. The residue was dissolved in methylene chloride, extracted with 1N hydrochloric acid and water, dried and concentrated under reduced pressure. This gave 0.67 g (76% of theory) of the title compound of melting point 112-118° C. Following trituration with diethyl ether, the melting point was 115-120° C.

## Claims

1. A nitrobenzoylsulfamic acid amide of Formula I




where R1 and R2, independently of one another, are C1-C6 alkyl; and each optionally is substituted with one of cyano, nitro, formyl, phenyl, halo, C1-C4 alkoxy, or C1-C4 alkylthio; and
where Ra and Rc are halogen and where Rb and Rd are hydrogen.

2. The nitrobenzoylsulfamic acid amide of formula I according to claim 1 wherein R1 is methyl; R2 is isopropyl; Ra is chlorine; and Rc is fluorine.

3. A method of preparing the nitrobenzoylsulfamic acid amide of formula I according to claim 1, which comprises:
a) reacting an aroyl compound of Formula II





where Ra and Rc are halogen and where Rb and Rd are hydrogen; and
where X is halogen or C1-C4 alkoxy;

with a sulfamic acid amide of Formula III


H2N—SO2—NR1R2  III

where R1 and R2, independently of one another, are C1-C6 alkyl.

4. A method of preparing an aminobenzoylsulfamic acid amide of Formula IV



where R1 and R2, independently of one another, are C1-C6 alkyl; and
where Ra and Rc are halogen and where Rb and Rd are hydrogen;


which comprises reducing the nitrobenzoylsulfamic acid amide of formula I according to claim 1.

5. A method of preparing a phenyl iso(thio)cyanate of Formula V



where R1 and R2, independently of one another, are C1-C6 alkyl;
where Ra and Rc are halogen and where Rb and Rd are hydrogen; and
where W is oxygen or sulfur,

which comprises
a) reacting an aroyl compound of Formula II



where Ra and Rc are halogen and where Rb Rd are hydrogen; and
where X is halogen or C1-C4 alkoxy,

with a sulfamic acid amide of Formula III


H2N—SO2—NR1R2  III

where R1 and R2, independently of one another, are C1-C6 alkyl,

to form the nitrobenzoylsulfamic acid amide of claim 1;
b) reducing said nitrobenzoylsulfamic acid amide to form an aminobenzoylsulfamic acid amide of Formula IV



where R1 and R2, independently of one another, are C1-C6 alkyl, and
where Ra and Rc are halogen and where Rb and Rd are hydrogen; and

c) reacting said aminobenzoylsulfamic acid amide of Formula IV with phosgene, thiophosgene of diphosgene, to form said phenyl iso(thio)cyanate of Formula V.

6. The method of claim 5 wherein said nitrobenzoylsulfamic acid amide is a nitrobenzoylsulfamic acid of formula I




where R1 is methyl, R2 is isopropyl, Ra is chlorine, and Rc is fluorine.