# Patent

## Title
Pesticidal compositions

## Abstract

The present disclosure relates to pesticidal compositions and to methods for controlling pests such as insects and other arthropods. More particularly, the disclosure relates to a pesticidal compositions containing mineral oil and one or more additional components which, when used in combination, act synergistically to control insect and pest populations.

## Background
CROSS-REFERENCE TO RELATED APPLICATIONS
This application claims the benefit of U.S. Provisional Application No. 61/044,297 filed Apr. 11, 2008 and U.S. Provisional Application No. 61/115,231, filed Nov. 17, 2008.


BACKGROUND OF THE DISCLOSURE
The present disclosure relates to pesticidal compositions and a method of controlling insects and other pests. More particularly, the disclosure relates to pesticidal compositions containing mineral oil and one or more additional components which, when used in combination, act synergistically to control pests such as arthropods.
Insects and other arthropod pests can have negative effects on the quality of human life. For instance, when found in the home, insects and other arthropods can be a source of annoyance due purely to their presence. They may also spread disease and allergens. Additionally, when found on plants and crops, insects and other pest arthropods can destroy foliage and fruit, and may adversely affect plant and crop growth, quality, and yield.
Among the insects which are particularly undesirable are domestic cockroaches. These insects produce allergens in their saliva, fecal material, cast skins and body parts which may be particularly problematic for people suffering from allergies.
It is domestically and commercially desirable to control cockroaches through the use of pesticide products. It is also desirable for to control other crawling arthropods, such as ants, beetles, earwigs, silverfish, crickets, spiders, centipedes and various flying insects including flies, mosquitoes, gnats, moths, wasps, hornets, bees, and the like.
A broad range of compounds have been found to be toxic to insects and other arthropods such that formulations containing the compounds may be used for their control. However, most compounds damage the environment and adversely affect human health. There is a need for new pesticides which are generally safe to the environment and non-toxic to humans and animals and which are effective at controlling insect and other pest populations.
SUMMARY OF THE DISCLOSURE
The present disclosure relates to pesticidal compositions and a method of controlling pests such as arthropods and, in particular, insects. The pesticidal compositions of embodiments of the present disclosure are particularly effective at controlling cockroaches. More particularly, the disclosure relates to a pesticidal composition containing mineral oil and one or more additional components which, when used in combination, act synergistically to control insect and other pest populations.
In one aspect, the present disclosure is directed to a pesticidal composition comprising a first active ingredient and a second active ingredient. The first active ingredient is a mineral oil and the second active ingredient is an ester compound. The ester compound is selected from the group consisting of ethyl lactate, γ-butyrolactone, triacetin and combinations thereof.
In another aspect, the pesticidal composition comprises a first active ingredient and a second active ingredient. The first active ingredient is a mineral oil and the second active ingredient is an alcohol selected from the group consisting of methanol, 1-proponal, 1-butanol, 1-hexanol, 1-heptanol, 1-octanol, 1-nonanol, 1-decanol, 1-undecanol, 1-dodecanol, 1-tetradecanol, 2-butanol, isobutyl alcohol, tertiary butyl alcohol, 2-butoxyethanol, 2-phenylethanol, diacetone alcohol, 2-ethoxyethanol and combinations thereof.
In yet another aspect, the pesticidal composition comprises a first active ingredient and a second active ingredient. The first active ingredient is a mineral oil and the second active ingredient is selected from the group consisting of hexylene glycol, dioxane, nitromethane, acetophenone, pyridine and combinations thereof.
In another aspect, the present disclosure is directed to a method of controlling arthropods. An arthropod is contacted with a pesticidally effective amount of a composition comprising a first active ingredient and a second active ingredient. The first active ingredient is a mineral oil and the second active ingredient is an ester compound.
In a further aspect of the method, an arthropod is contacted with a pesticidally effective amount of a composition comprising a first active ingredient and a second active ingredient. The first active ingredient is a mineral oil and the second active ingredient is an alcohol selected from the group consisting of methanol, 1-proponal, 1-butanol, 1-hexanol, 1-heptanol, 1-octanol, 1-nonanol, 1-decanol, 1-undecanol, 1-dodecanol, 1-tetradecanol, 2-butanol, isobutyl alcohol, tertiary butyl alcohol, 2-butoxyethanol, 2-phenylethanol, diacetone alcohol, 2-ethoxyethanol and combinations thereof.
In yet another aspect of the method, the arthropod is contacted with a pesticidally effective amount of a composition comprising a first active ingredient and a second active ingredient. The first active ingredient is a mineral oil and the second active ingredient is selected from the group consisting of hexylene glycol, dioxane, d-limonene, nitromethane, acetophenone, pyridine and combinations thereof.
A further aspect of the present disclosure is directed to a method of controlling cockroaches. A cockroach is contacted with a pesticidally effective amount of a composition comprising a first active ingredient and at least 3% of a second active ingredient by weight of the composition. The first active ingredient is a mineral oil and the second active ingredient is an alcohol.
Other objects and features will be in part apparent and in part pointed out hereinafter.



BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is a chart depicting the effects of compositions comprising mineral oil and/or ethyl lactate on the mortality of adult German cockroaches as discussed in Example 1.
FIG. 2 is a chart depicting the effects of compositions comprising mineral oil and/or butyl lactate on the mortality of adult German cockroaches as discussed in Example 2.



DETAILED DESCRIPTION OF THE DISCLOSURE
In accordance with the present disclosure, it has now been found that the combination of mineral oil and one or more additional compounds selected from the group consisting of ethyl lactate, butyl lactate, isopropyl myristate, hexylene glycol, dioxane, d-limonene, a C1-C14 saturated straight-chain alcohol, isopropyl alcohol, 2-butanol, isobutyl alcohol, tertiary butyl alcohol, 2-butoxyethanol, 2-phenylethanol, diacetone alcohol, and combinations thereof, is effective for use in controlling insect and other pest populations. In particular, it has been discovered that compositions comprising mineral oil in combination with ethyl lactate, butyl lactate, isopropyl myristate, hexylene glycol, dioxane, d-limonene, a C1-C14 saturated straight-chain alcohol, isopropyl alcohol, 2-butanol, isobutyl alcohol, tertiary butyl alcohol, 2-butoxyethanol, 2-phenylethanol, diacetone alcohol, γ-butyrolactone, nitromethane, acetophenone, triacetin, pyridine, 2-ethoxyethanol or combinations thereof are more effective at killing targeted insects and pests than compositions comprising only mineral oil or compositions comprising ethyl lactate, butyl lactate, isopropyl myristate, hexylene glycol, dioxane, d-limonene, a C1-C14 saturated straight-chain alcohol, isopropyl alcohol, 2-butanol, isobutyl alcohol, tertiary butyl alcohol, 2-butoxyethanol, 2-phenylethanol, diacetone alcohol, γ-butyrolactone, nitromethane, acetophenone, triacetin, pyridine, or 2-ethoxyethanol but no mineral oil. Advantageously, the compositions of the present disclosure also have a generally lower or reduced non-target (e.g., humans, other mammals, birds and reptiles) toxicity as compared to many other known pest control materials.
Thus, in one aspect, the present disclosure is directed to a pesticidal composition comprising a first active ingredient and a second active ingredient, the first active ingredient being mineral oil, and the second active ingredient being selected from the group consisting of ethyl lactate, butyl lactate, isopropyl myristate, hexylene glycol, dioxane, d-limonene, a C1-C14 saturated straight-chain alcohol, isopropyl alcohol, 2-butanol, isobutyl alcohol, tertiary butyl alcohol, 2-butoxyethanol, 2-phenylethanol, diacetone alcohol, γ-butyrolactone, nitromethane, acetophenone, triacetin, pyridine, 2-ethoxyethanol and combinations thereof. The composition may be sprayed or otherwise applied directly on crawling or flying insects or other arthropod pests in sufficient concentrations to kill the pests.
As noted above, the pesticidal compositions of the present disclosure comprise a first active ingredient which is mineral oil. Any type of mineral oil may be used in the pesticidal compositions. In one preferred embodiment, the mineral oil is PD-23 (available from Chemtura Corporation, Middlebury, Conn.). PD-23 is a light grade petroleum distillate having a flash point of 230° F. (110° C.), as measured by ASTM D-92, and a vapor pressure of less than 0.1 mmHg at 20° C. PD-23 is a highly refined petroleum distillate that physically resembles a very light, clear oil, and is made by fractionating oil to a narrow boiling range, then catalytically hydrotreating it to remove all aromatic and other unsaturated hydrocarbons. PD-23 is hydrophobic, colorless, tasteless, virtually odorless, and color fast. PD-23 generally has a low viscosity, e.g., about 2.6 centistokes (cSt) at 40° C. or a Saybolt Universal Seconds (SUS) viscosity of about 34 SUS at 100° F. (38° C.).
Other types of suitable mineral oils may also be used including, for example, PD-25 and PD-28 (both available from Chemtura Corporation, Middlebury, Conn.). PD-25 typically has a viscosity of about 3.5 cSt at 40° C. or about 39 SUS at 100° F. (38° C.). PD-28 typically has a viscosity of about 4.2 cSt at 40° C. or about 39 SUS at 100° F. (38° C.). Another suitable mineral oil is EXXSOL D95 (available from Exxon Mobil). EXXSOL D95 is a de-aromatized petroleum distillate. EXXSOL D95 typically has a viscosity of about 1.92 cSt at 40° C.
Typically, the viscosity of the mineral oil will range from about 2.0 cSt at 40° C. to about 5.0 cSt at 40° C., and more typically will be from about 2.6 cSt at 40° C. to about 4.2 cSt at 40° C. In other embodiments the viscosity of the mineral oil is from about 1.5 cSt to about 5.0 cSt at 40° C. In general, it has been determined that pesticidal compositions of the present disclosure that comprise a mineral oil having a relatively low viscosity are more effective at killing pests than pesticidal compositions comprising mineral oil having a higher viscosity.
In one embodiment, the pesticidal composition comprises more than one mineral oil. The total amount of mineral oil present in the pesticidal composition may be at least about 5% (by weight of the composition), at least about 10% (by weight of the composition), at least about 20% (by weight of the composition), at least about 30% (by weight of the composition), at least about 40% (by weight of the composition), or even at least about 50% (by weight of the composition).
Typically, the pesticidal compositions will comprise from about 5% (by weight of the composition) to about 90% (by weight of the composition) of mineral oil, and more typically from about 40% (by weight of the composition) to about 80% (by weight of the composition) of mineral oil.
In some embodiments, the mineral oil is a petroleum distillate composition. The amount of petroleum distillate composition in the pesticidal composition may generally be the same as the amounts listed for the mineral oil as described above.
In addition to mineral oil, the pesticidal compositions of the present disclosure further comprise at least one second active ingredient selected from the group consisting of ethyl lactate, butyl lactate, isopropyl myristate, hexylene glycol, dioxane, d-limonene, a C1-C14 saturated straight-chain alcohol, isopropyl alcohol, 2-butanol, isobutyl alcohol, tertiary butyl alcohol, 2-butoxyethanol, 2-phenylethanol, diacetone alcohol, γ-butyrolactone, nitromethane, acetophenone, triacetin, pyridine, 2-ethoxyethanol and combinations thereof. Advantageously, these second active ingredients act synergistically with mineral oil to provide a pesticidal composition that is effective in controlling insect and other pest populations. Surprisingly, as can be seen from the examples set forth hereinafter, compositions comprising a combination of mineral oil and one or more of ethyl lactate, butyl lactate, isopropyl myristate, hexylene glycol, dioxane, d-limonene, a C1-C14 saturated straight-chain alcohol, isopropyl alcohol, 2-butanol, isobutyl alcohol, tertiary butyl alcohol, 2-butoxyethanol, 2-phenylethanol and diacetone alcohol, γ-butyrolactone, nitromethane, acetophenone, triacetin, pyridine, 2-ethoxyethanol, are substantially more effective in killing insects than either mineral oil in the absence of one of these second active ingredients, or any of the second active ingredients in the absence of mineral oil.
In one embodiment, the pesticidal composition comprises more than one second active ingredient. The additional second active ingredient or ingredients may generally be selected from the list of compounds described above or below as potential second active ingredients.
The total amount of second active ingredient or ingredients present in the pesticidal composition may be at least about 3% (by weight of the composition), at least about 5% (by weight of the composition), at least about 10% (by weight of the composition), at least about 20% (by weight of the composition), at least about 30% (by weight of the composition), at least about 40% (by weight of the composition), or even at least about 50% (by weight of the composition).
The total amount of second active ingredient present in the pesticidal compositions will typically be from about 3% (by weight of the composition) to about 95% (by weight of the composition), more typically from about 5% (by weight of the composition) to about 95% (by weight of the composition), and more preferably from about 10% (by weight of the composition) to about 60% (by weight of the composition).
The amount of each particular second active ingredient present in the composition may vary depending on the ingredient, the amount of mineral oil in the composition, and whether or not more than one second active ingredient is present in the composition.
In one embodiment, the second active ingredient is selected from ethyl lactate, butyl lactate, isopropyl myristate, hexylene glycol, dioxane, d-limonene and combinations thereof. In another embodiment, the second active ingredient is selected from ethyl lactate, butyl lactate, isopropyl myristate, d-limonene and combinations thereof. In yet another embodiment, the second active ingredient is selected from the group consisting of ethyl lactate, isopropyl myristate, hexylene glycol, dioxane, d-limonene and combinations thereof and, in a further embodiment, ethyl lactate, isopropyl myristate, d-limonene and combinations thereof.
Typically, ethyl lactate may be present in the composition in an amount of from about 5% (by weight of the composition) to about 95% (by weight of the composition), and more preferably from about 10% (by weight of the composition) to about 60% (by weight of the composition). Compositions comprising about 12.5% (by weight of the composition) mineral oil and about 37.5% (by weight of the composition) ethyl lactate, or about 25% (by weight of the composition) mineral oil and about 25% (by weight of the composition) ethyl lactate, or about 37.5% (by weight of the composition) mineral oil and about 12.5% (by weight of the composition) ethyl lactate, or about 5% (by weight of the composition) mineral oil and about 45% (by weight of the composition) ethyl lactate have been found to be particularly effective at killing insects such as cockroaches.
Butyl lactate may be present in the composition in an amount of from about 5% (by weight of the composition) to about 90% (by weight of the composition), more preferably from about 10% (by weight of the composition) to about 80% (by weight of the composition), and more preferably from about 10% (by weight of the composition) to about 60% (by weight of the composition). Compositions comprising about 12.5% (by weight of the composition) mineral oil and about 37.5% (by weight of the composition) butyl lactate, or about 25% (by weight of the composition) mineral oil and about 25% (by weight of the composition) butyl lactate, or about 37.5% (by weight of the composition) mineral oil and about 12.5% (by weight of the composition) butyl lactate have been found to be particularly effective at killing insects such as cockroaches.
Isopropyl myristate may be present in the composition in an amount of from about 5% (by weight of the composition) to about 95% (by weight of the composition), more preferably from about 10% (by weight of the composition) to about 80% (by weight of the composition), and more preferably from about 10% (by weight of the composition) to about 60% (by weight of the composition). Compositions comprising about 60% (by weight of the composition) mineral oil and about 20% (by weight of the composition) isopropyl myristate, or about 50% (by weight of the composition) mineral oil and about 30% (by weight of the composition) isopropyl myristate, or about 40% (by weight of the composition) mineral oil and about 40% (by weight of the composition) isopropyl myristate have been found to be particularly effective at killing insects such as cockroaches.
Hexylene glycol may be present in the composition in an amount of from about 5% (by weight of the composition) to about 90% (by weight of the composition), and more preferably from about 10% (by weight of the composition) to about 60% (by weight of the composition). Compositions comprising about 60% (by weight of the composition) mineral oil and about 20% (by weight of the composition) hexylene glycol have been found to be particularly effective at killing insects such as cockroaches.
Dioxane may be present in the composition in an amount of from about 5% (by weight of the composition) to about 80% (by weight of the composition), more preferably from about 5% (by weight of the composition) to about 60% (by weight of the composition), and more preferably from about 10% (by weight of the composition) to about 60% (by weight of the composition). Compositions comprising about 40% (by weight of the composition) mineral oil and about 40% (by weight of the composition) dioxane have been found to be particularly effective at killing insects such as cockroaches.
D-limonene may be present in the composition in an amount of from about 3% (by weight of the composition) to about 90% (by weight of the composition), and more preferably from about 5% (by weight of the composition) to about 90% (by weight of the composition), and more preferably from about 5% (by weight of the composition) to about 60% (by weight of the composition). Compositions comprising about 40% (by weight of the composition) mineral oil and about 40% (by weight of the composition) d-limonene have been found to be particularly effective at killing insects such as cockroaches.
In one embodiment, the second active ingredient is an ester compound. When ester compounds are present in the pesticidal composition as a second active ingredient, additional second active ingredients that are not ester compounds may also be present in the composition. The amount of ester compounds that are present in the pesticidal composition may be at least about 50% of all the second active ingredients, at least about 65% of all the second active ingredients, at least about 75% of all the second active ingredients, at least about 85% of all the second active ingredients, at least about 95% of all the second active ingredients, or even at least about 99% of all the second active ingredients. In one embodiment, the total amount (i.e., about 100%) of second active ingredients present in the pesticidal composition is ester compounds.
The ester compounds present in the pesticidal composition may be selected from the group consisting of ethyl lactate, butyl lactate, isopropyl myristate, γ-butyrolactone, triacetin and combinations thereof. These listed esters may be present in the pesticidal composition in an amount of at least about 1% by weight of the composition, at least about 3%, at least about 5%, at least about 10% or even at least about 15% by weight of the composition. In one embodiment, the ester compounds are present in an amount from about 10% to about 60% by weight of the composition.
In another embodiment, the ester compounds are selected from the group consisting of ethyl lactate, butyl lactate, isopropyl myristate and combinations thereof. In yet another embodiment, the ester compounds are selected from the group consisting of ethyl lactate, γ-butyrolactone, triacetin and combinations thereof. In yet another aspect, the ester compounds are selected from the group consisting of ethyl lactate, γ-butyrolactone, triacetin and combinations thereof.
In one embodiment, the second active ingredient is an alcohol. The pesticidal composition may include one alcohol compound or more than one alcohol compound without departing from the scope of the present disclosure. When alcohols are present in the pesticidal composition as a second active ingredient, additional second active ingredients that are not alcohols may also be present in the composition. The amount of alcohol present in the pesticidal composition may be at least about 50% of all the second active ingredients, at least about 65% of all the second active ingredients, at least about 75% of all the second active ingredients, at least about 85% of all the second active ingredients, at least about 95% of all the second active ingredients, or even at least about 99% of all the second active ingredients. In one embodiment, the total amount (i.e., about 100%) of second active ingredients present in the pesticidal composition is an alcohol or alcohols.
The alcohol utilized in the second active ingredient may be selected from the group consisting of C1-C14 saturated straight-chain alcohols, isopropyl alcohol, 2-butanol, isobutyl alcohol, tertiary butyl alcohol, 2-butoxyethanol, 2-phenylethanol, diacetone alcohol, 2-ethoxyethanol and combinations thereof. These alcohols may be present in the pesticidal composition in at least about 1%, at least about 3%, at least about 5%, at least about 10% or even at least about 15% by weight of the composition. In one embodiment, the alcohols are present in an amount from about 10% to about 60% by weight of the composition.
In one embodiment, the alcohol is selected from the group consisting of methanol, 1-proponal, 1-butanol, 1-hexanol, 1-heptanol, 1-octanol, 1-nonanol, 1-decanol, 1-undecanol, 1-dodecanol, 1-tetradecanol, 2-butanol, isobutyl alcohol, tertiary butyl alcohol, 2-butoxyethanol, 2-phenylethanol, diacetone alcohol, 2-ethoxyethanol and combinations thereof. In a further embodiment, the alcohol is selected from methanol, 1-proponal, 1-butanol, 1-hexanol, 1-heptanol, 1-octanol, 1-nonanol, 1-decanol, 1-undecanol, 1-dodecanol, 1-tetradecanol, 2-butanol, isobutyl alcohol, tertiary butyl alcohol, 2-butoxyethanol, 2-phenylethanol, diacetone alcohol and combinations thereof. The alcohol may also be selected from the group consisting of 2-butanol, isobutyl alcohol, tertiary butyl alcohol, 2-butoxyethanol, 2-phenylethanol, diacetone alcohol, 2-ethoxyethanol and combinations thereof.
In another embodiment, the alcohol is selected from the group consisting of C1-C14 saturated straight-chain alcohols, isopropyl alcohol, 2-butanol, isobutyl alcohol, tertiary butyl alcohol, 2-butoxyethanol, 2-phenylethanol, diacetone alcohol, 2-ethoxyethanol and combinations thereof.
The pesticidal composition may include a plurality of alcohol compounds including a plurality of C1-C 14 saturated straight chain alcohols. In one embodiment, the C1-C14 saturated straight-chain alcohol is selected from the group consisting of methanol, ethanol, 1-proponal, 1-butanol, 1-hexanol, 1-heptanol, 1-octanol, 1-nonanol, 1-decanol, 1-undecanol, 1-dodecanol, 1-tetradecanol and combinations thereof.
In another embodiment, the alcohol is a C1-C9 saturated straight-chain alcohol and, in another embodiment, is a C1-C6 straight chain alcohol. In one embodiment, the alcohol is a C3-C7 saturated straight-chain alcohol.
In a particular embodiment, mineral oil and a second active ingredient selected from the group consisting of C1-C14 saturated straight-chain alcohol, isopropyl alcohol, 2-butanol, isobutyl alcohol, tertiary butyl alcohol, 2-butoxyethanol, 2-phenylethanol or diacetone alcohol may be present in the composition in a ratio based on the LD10 or LD50 value of the alcohol, which optimizes the biological effect of the blend.
For example, where the second active ingredient is isopropyl alcohol, 2-butanol, isobutyl alcohol, tertiary butyl alcohol, 2-butoxyethanol, 2-phenylethanol, diacetone alcohol, or a C1-C14 saturated straight chain alcohol, the LD10 of each of the active ingredients is determined, for instance, by the methods described in Example 9. A ratio is then determined based on about half of the LD10 for mineral oil and about the LD10 of the second active ingredient. For example, as detailed in Example 9, the LD10 for PD23 mineral oil was determined to be 0.754 mg/insect and the LD10 for diacetone alcohol was determined to be 0.255 mg/insect. About half of the LD10 of PD23 is about 0.4 mg, while about the LD10 of diacetone alcohol is about 0.3 mg. Accordingly, for a composition comprising PD23 and diacetone alcohol, a ratio corresponding to the above amounts is 4 parts PD23 to 3 parts diacetone alcohol, or 4:3. Thus, a composition of this particular embodiment may comprise PD23 and diacetone alcohol, among other things, in a ratio of 4:3.
Similarly, for example, in a composition comprising PD23 and 1-propanol, those active ingredients may be present in the composition in a ratio of about 4:4.5 or about 1:1. The ratio is determined based on the LD10 for 1-propanol and PD23, respectively, of 0.472 mg/insect and 0.754 mg/insect. About half the LD10 of PD23 is about 0.4 mg, and the LD10 of 1-propanol is about 0.45 mg, giving a ratio of about 4:4.5, or about 1:1.
Alternatively, the ratio may be determined as above, but based on the LD10:LD10 of the mineral oil and second active ingredient. So, for example, in a composition comprising PD23 and 1-propanol, the PD23 and 1-propanol are present in a ratio of 8:4.5, or about 2:1.
Similarly, a C1-C14 saturated straight-chain alcohol, isopropyl alcohol, 2-butanol, isobutyl alcohol, tertiary butyl alcohol, 2-butoxyethanol, 2-phenylethanol or diacetone alcohol may be present in the composition in a ratio relative to the mineral oil in the composition, where this ratio is determined based on the LD50 for the alcohol and the LD50 of the mineral oil. As above with respect to ratios based on LD10, such ratios may be determined based on LD50:LD50; or may alternatively be determined based on 0.5 LD50 for mineral oil and LD50 for the second active ingredient.
In another embodiment, mineral oil and a second active ingredient selected from the group consisting of C1-C14 saturated straight-chain alcohol, isopropyl alcohol, 2-butanol, isobutyl alcohol, tertiary butyl alcohol, 2-butoxyethanol, 2-phenylethanol, diacetone alcohol, 2-ethoxyethanol or combinations thereof may be present in the composition in a ratio which may be determined based on the LD10 or LD50.
In one embodiment, the second active ingredient is a compound selected from the group consisting of hexylene glycol, dioxane, d-limonene, nitromethane, acetophenone, pyridine and combinations thereof. These listed compounds may be included with other second active ingredients. The amount of the listed compounds in the pesticidal composition may be at least about 50% of all the second active ingredients, at least about 65% of all the second active ingredients, at least about 75% of all the second active ingredients, at least about 85% of all the second active ingredients, at least about 95% of all the second active ingredients, or even at least about 99% of all the second active ingredients. In one embodiment, the total amount (i.e., about 100%) of second active ingredients present in the pesticidal composition is compounds selected from hexylene glycol, dioxane, d-limonene, nitromethane, acetophenone, pyridine and combinations thereof.
In another embodiment, the second active ingredient is selected from the group consisting of hexylene glycol, dioxane, d-limonene, nitromethane, acetophenone, pyridine and combinations thereof.
In another embodiment, the second active ingredient is selected from hexylene glycol, dioxane, d-limonene and combinations thereof. In a further embodiment, the second active ingredient is selected from nitromethane, acetophenone, pyridine and combinations thereof.
These compounds may be present in the pesticidal composition in at least about 1%, at least about 3%, at least about 5%, at least about 10% or even at least about 15% by weight of the composition. In one embodiment, the listed compounds are present in an amount from about 10% to about 60% by weight of the composition.
In certain embodiments, the pesticidal compositions may comprise mineral oil plus two or more of the second active ingredients. For instance, in one particular embodiment, the pesticidal composition comprises mineral oil, ethyl lactate, and isopropyl myristate. In this embodiment, the pesticidal composition preferably comprises from about 5% (by weight of the composition) to about 30% (by weight of the composition) of ethyl lactate, and more typically from about 5% (by weight of the composition) to about 15% (by weight of the composition) of ethyl lactate; from about 5% (by weight of the composition) to about 60% (by weight of the composition) of isopropyl myristate, and more typically from about 5% (by weight of the composition) to about 30% (by weight of the composition) of isopropyl myristate; and from about 20% (by weight of the composition) to about 70% (by weight of the composition) of mineral oil.
In another particular embodiment, the pesticidal composition comprises mineral oil, d-limonene, and ethyl lactate. In this embodiment, the pesticidal composition preferably comprises from about 5% (by weight of the composition) to about 60% (by weight of the composition) of d-limonene, from about 5% (by weight of the composition) to about 30% (by weight of the composition) of ethyl lactate, and from about 20% (by weight of the composition) to about 90% (by weight of the composition) of mineral oil.
In yet another particular embodiment, the pesticidal composition comprises mineral oil, d-limonene, and butyl lactate. In this embodiment, the pesticidal composition preferably comprises from about 5% (by weight of the composition) to about 20% (by weight of the composition) of d-limonene, from about 5% (by weight of the composition) to about 20% (by weight of the composition) of butyl lactate, and from about 30% (by weight of the composition) to about 80% (by weight of the composition) of mineral oil.
In still another particular embodiment, the pesticidal composition may comprise mineral oil, d-limonene, ethyl lactate, and isopropyl myristate. In this embodiment, the pesticidal composition preferably comprises from about 5% (by weight of the composition) to about 20% (by weight of the composition) of d-limonene, from about 5% (by weight of the composition) to about 20% (by weight of the composition) of ethyl lactate, from about 20% (by weight of the composition) to about 40% (by weight of the composition) of isopropyl myristate, and from about 30% (by weight of the composition) to about 80% (by weight of the composition) of mineral oil.
In addition to the first and one or more second active ingredients, the pesticidal compositions of the present disclosure may further comprise a plant essential oil or derivative thereof, which may also have pesticidal properties. Such plant essential oils or derivatives may be extracted from natural sources or synthetically made, and generally contain, as at least one major constituent, an acyclic monoterpene alcohol or aldehyde, a benzenoid aromatic compound containing at least one oxygenated substituent or side chain, or a monocarbocyclic terpene generally having a six membered ring bearing one or more oxygenated substituents. Examples of such essential oils or their derivatives include, but are not limited to, members selected from the group consisting of aldehyde C16 (pure), alpha-terpineol, amyl cinnamic aldehyde, amyl salicylate, anisic aldehyde, benzyl alcohol, benzyl acetate, cinnamaldehyde, cinnamic alcohol, carvacrol, carveol, citral, citronellal, citronellol, dimethyl salicylate, eucalyptol (cineole), eugenol, iso-eugenol, galaxolide, geraniol, guaiacol, ionone, menthol, methyl anthranilate, methyl ionone, methyl salicylate, nerol, alpha-phellandrene, pennyroyal oil, perillaldehyde, 1- or 2-phenyl ethyl alcohol, 1- or 2-phenyl ethyl propionate, piperonal, piperonyl acetate, piperonyl alcohol, D-pulegone, terpinen-4-ol, terpinyl acetate, 4-tert butylcyclohexyl acetate, thyme oil (white and red), thymol, trans-anethole, vanillin, ethyl vanillin, and the like.
Other suitable oils include, for example, castor oil, cedar oil, cinnamon and cinnamon oil, citronella and citronella oil, cloves and clove oil, corn oil, cottonseed oil, garlic and garlic oil, geranium oil, lemongrass oil, linseed oil, mint and mint oil, peppermint and peppermint oil, rosemary and rosemary oil, sesame and sesame oil, soybean oil, white pepper, and the like. Preferably, the plant essential oil or derivative is geraniol.
The pesticidal compositions will typically comprise from about 1% (by weight of the composition) to about 60% (by weight of the composition of the plant essential oil or derivative, more typically from about 2% (by weight of the composition) to about 60% (by weight of the composition), and more typically from about 2% (by weight of the composition) to about 20% (by weight of the composition) of the plant essential oil or derivative.
In one embodiment, the pesticidal composition includes a first active ingredient that is a mineral oil, at least one second active ingredient that is selected from the group consisting of ethyl lactate, butyl lactate, isopropyl myristate, hexylene glycol, dioxane, d-limonene, a C1-C14 saturated straight-chain alcohol, isopropyl alcohol, 2-butanol, isobutyl alcohol, tertiary butyl alcohol, 2-butoxyethanol, 2-phenylethanol, diacetone alcohol, and combinations thereof and a third active ingredient that is a plant essential oil or derivative. In one embodiment, the plant essential oil or derivative is geraniol. In another embodiment, the composition also includes nerol.
In one embodiment, the composition comprises from about 10% to about 70% of the first ingredient by weight of the composition, from about 5% to about 50% of the second ingredient by weight of the composition and from about 0.5% to about 15% of the third active ingredient by weight of the composition.
The amount of geraniol present in the composition may be at least about 2% by weight of the composition, at least about 4% or at least about 6% by weight of the composition. In one embodiment, the amount of geraniol present in the composition is from about 0.5% to about 8% by weight of the composition. Nerol may be present in the composition in an amount from about 0.5% to about 3% by weight of the composition.
In another embodiment, the pesticidal composition comprises mineral oil, and at least two second active ingredients, each second active ingredient being selected from the group consisting of ethyl lactate, butyl lactate, isopropyl myristate, hexylene glycol, dioxane, d-limonene, a C1-C14 saturated straight-chain alcohol, isopropyl alcohol, 2-butanol, isobutyl alcohol, tertiary butyl alcohol, 2-butoxyethanol, 2-phenylethanol, diacetone alcohol, and combinations thereof and a third active ingredient that is a plant essential oil or derivative. In one embodiment, the plant essential oil or derivative is geraniol. In another embodiment, the composition also includes nerol.
In another embodiment, the pesticidal composition comprises a mineral oil, ethyl lactate, isopropyl myristate and geraniol. The composition may also include nerol. Additional additives may include essential oils such as lemongrass oil and carbon dioxide (described below).
In one embodiment, the pesticidal composition comprises, by weight of the composition, about 43% mineral oil, about 15% ethyl lactate, about 30% isopropyl myristate and about 6% geraniol. The composition may also include about 3% nerol and about 1% lemongrass oil.
Additionally, the pesticidal composition may further comprise other known insecticidal or pesticidal agents, including, for example, synergists such as piperonyl butoxide, MGK 264, and dillapiol; as well as other plant-derived insecticidal or pesticidal materials such as pyrethrum.
The composition may also comprise an amount of water. In various embodiments, the composition contains water in an amount of, by weight of the composition, at least about 10%, at least about 25%, at least about 50% or even at least about 75%. In one embodiment, the amount of water in the solution is from about 10% to about 50% by weight of the composition and, in another embodiment, from about 25% to about 75% by weight of the composition.
The compositions of the present disclosure may further comprise a suitable solvent, carrier or emulsifier. Examples of suitable solvents or carriers include water, acetone, alcohols such as ethanol and isopropyl alcohol, dimethyl ether, and chlorinated hydrocarbon solvents such as methylene chloride and methyl chloroform. Examples of emulsifiers would include soaps (such as fatty acid soaps), cationic, ionic and non-ionic compounds. Additional carriers for use in various granular formulations include, for example, corn cob grits, diatomaceous earth, sand, clay, and the like.
The pesticidal compositions of the present disclosure may be dispensed in any conventional manner, e.g., from a standard pump-spray container. In one embodiment, the pesticide is in a ready-to-use form in which the composition does not need to be diluted before application. Alternatively, the pesticidal composition may be in a concentrate form. The end-user of the concentrate composition may dilute the concentrate prior to use by, for example, addition of water. In one embodiment, the pesticidal composition is diluted in the pump spray bottle. In various embodiments, the concentrate pesticidal composition may be diluted by addition of water in an amount of, by weight of the concentrate composition, at least about 40%, at least about 50%, at least about 75%, at least about 100%, at least about 150%, at least about 200% or even at least about 300%.
When the pesticidal composition is present in a concentrate form, in some embodiments, dilution may cause formation of a water-concentrate emulsion. The pesticidal concentrate may include emulsifiers such as surfactants (e.g., surfactants such as fatty acid soaps). Suitable compounds may be cationic, ionic, and non-ionic. Suitable emulsifying compounds include alkyl aryl sulionate-based emulsifiers, polyoxyethylenes and long-chain alcohols.
In one embodiment, the pesticidal composition is packaged in a pressurized container such as a conventional aerosol container or the like. The composition may be pressurized utilizing any suitable propellant. Examples of suitable propellants include expandable gases such as carbon dioxide, nitrogen, propane, n-butane, isobutane, blends of propane and butane, HFC-152a (difluoroethane), HFC-134a (1,1,1,2-tetrafluoroethane), and combinations thereof.
Any conventional technique may be used to charge the aerosol container with carbon dioxide or other expandable gas. In one embodiment, the gasser-shaker method may be used. This method involves shaking or agitating the container and its contents as the carbon dioxide (or other gas) is forced into the container through a valve, with the rest of the composition having been introduced into the container prior to installation of the valve. The rate of injection of the gas depends on the valve orifice size, and the shaking time depends on the container size, the amount of liquid, and the degree of agitation, as well as the temperature.
Alternatively, the pesticidal composition may be saturated with carbon dioxide prior to introduction into the container, and then pumped under pressure to a rotary undercap filler and filled as in a normal undercap operation, or pressured into containers already equipped with valves. Other suitable methods known in the art may also be used.
Other examples of suitable propellants which may be used are known in the art and include, for example, dimethyl ether, methyl ethyl ether, nitrous oxide, and the like.
Typically the composition will comprise propellant in an amount of from about 2% (by weight of the composition) to about 90% (by weight of the composition), and more typically in an amount of from about 2% (by weight of the composition) to about 10% (by weight of the composition).
As noted above, the pesticidal compositions of the present disclosure may be sprayed or otherwise contacted with insects or other pests to effectively control insect or other pest populations. Thus, in one embodiment, the present disclosure is directed to a method of controlling insects and pests. The method comprises contacting the insects and pests with a pesticidally effective amount of a composition of the present disclosure.
In one embodiment, an arthropod is contacted with the pesticidal composition in a pesticidally effective amount. For purposes of the present disclosure, a “pesticidally effective amount” of the composition includes amounts that repel the arthropod or other pest and may include, in another embodiment, amounts of the composition that kill the arthropod or other pest.
The pesticidal compositions of embodiments of the present disclosure may be used to control arthropods and, in another embodiment, to control insects. In one embodiment, the pesticidal composition is used to control cockroaches. Control of the pest (e.g., arthropod, insect, cockroach, etc.) may include contacting the pest with the pesticidal composition. In one embodiment, the pest is contacted with the pesticidal composition by spraying the composition directly on the crawling arthropod, flying insect or other pest. The composition may be sprayed in a sufficient amount to cause death. The pesticidal composition may also be sprayed in locations at which the pest is likely to come into contact with the composition.
The amount of the pesticidal composition required to kill insects or other pests and the time until pest death will vary depending on the composition components, the type of insect species and its life stage, and the like. The time required to kill a pest contacted with the pesticidal composition of the present disclosure will typically range from mere seconds to several hours.
The pesticidal compositions of the present disclosure are particularly effective against cockroaches, including the species Periplaneta Americana (American cockroach), Blattella germanica (German cockroach), Blattella asahinai (Asian cockroach), and Blatta orientalis (Oriental cockroach). However, the pesticidal compositions may also be used against a wide variety of other crawling insects or other arthropods, such as ants, water bugs, silverfish, crickets, spiders, ticks, mites, sowbugs, pillbugs, beetles, earwigs, centipedes, and the like. As used herein, the term “water bugs” refers to aquatic insects in the order Hemiptera. Examples of water bugs include giant water bugs, creeping water bugs, water scorpions, water boatmen, backswimmers, and the like. In one embodiment, the pesticidal compositions are effective against various flying insects including flies, mosquitoes, gnats, moths, wasps, hornets, bees, and the like.
The pesticidal compositions of the present disclosure generally result in at least 80% mortality, more preferably at least 95% mortality, and more preferably 100% mortality of the insects on contact, depending on the specific composition, the amount of composition applied to the insect and the insect species and life stage.
Having described the disclosure in detail, it will be apparent that modifications and variations are possible without departing from the scope of the disclosure defined in the appended claims.
EXAMPLES
The following non-limiting examples are provided to further illustrate the present disclosure.
Unless otherwise indicated, the mineral oil used in the following examples was PD-23 (available from Chemtura Corporation, Middlebury, Conn.), which is a light grade petroleum distillate having a flash point of 230° F. (110° C.), as measured by ASTM D-92, and a vapor pressure of less than 0.1 mmHg at 20° C. PD-23 is a highly refined petroleum distillate that resembles a very clear oil, and is made by fractionating oil to a narrow boiling range, then catalytically hydrotreating it to remove all aromatic and other unsaturated hydrocarbons. PD-23 is hydrophobic, colorless, tasteless, virtually odorless, and color fast.
Example 1
In this example, the effectiveness of compositions comprising various concentrations of mineral oil and/or ethyl lactate at killing German cockroaches was tested.
To begin, compositions comprising mineral oil and/or ethyl lactate in the following concentrations were prepared: 100% (wt/wt) mineral oil/0% (wt/wt) ethyl lactate; 90% (wt/wt) mineral oil/10% (wt/wt) ethyl lactate; 75% (wt/wt) mineral oil/25% (wt/wt) ethyl lactate; 50% (wt/wt) mineral oil/50% (wt/wt) ethyl lactate; 25% (wt/wt) mineral oil/75% (wt/wt) ethyl lactate; 10% (wt/wt) mineral oil/90% (wt/wt) ethyl lactate; 0% (wt/wt) mineral oil/100% (wt/wt) ethyl lactate. The ethyl lactate was obtained from Vertech Biosolvents, Inc., Downers Grove, Ill.
Prior to testing, each composition containing either mineral oil, ethyl lactate, or a combination of mineral oil and ethyl lactate was diluted by 50% by mixing the composition with acetone in a 1:1 ratio (wt/wt) to reduce viscosity prior to application of the compositions to the cockroaches. The amount of mineral oil, ethyl lactate, and acetone present in the final composition (A-G) is set forth below in Table 1.
Toxicity evaluations were performed on 7-14 day old adult male and female German cockroaches (SCJ Strain, S.C. Johnson & Son, Racine, Wis.). Approximately 12 cockroaches were transferred to individual 100×20 mm polystyrene Petri dishes and anesthetized with a 15-25 second exposure to carbon dioxide. The inside edge of each Petri dish was lightly coated with mineral oil plus petroleum jelly in a 1:3 (wt/wt) ratio to minimize escape. Anesthetized cockroaches were positioned with their ventral side up, and a 1 μl drop of the diluted test composition was applied to the area between the meso- and metathoracic legs using a Rainin L-10, 10 μl capacity pipette (Rainin Instrument, LLC, Oakland, Calif.). Five replications of 12 male cockroaches were done for each test composition. Separate tests were done using female cockroaches. Results were evaluated at 24 hours following treatment. Cockroaches were scored as either alive (dorsal side up, active movement when abdomen prodded with dissecting probe) or moribund/dead (dorsal side up and no movement when abdomen prodded or ventral side up and insect unable to right itself).
Results are shown in FIG. 1 and Table 1, which lists the number of dead cockroaches out of 60 total cockroaches for each test performed using the diluted test compositions (A-G).












TABLE 1







Ethyl

Males




Mineral
lactate
Acetone
(# dead
Females (#


Composition
oil (wt/wt)
(wt/wt)
(wt/wt)
out of 60)
dead out of 60)




















A
  50%
  0%
50%
6
1


B
  45%
  5%
50%
7
0


C
37.5%
12.5%
50%
40
20


D
  25%
  25%
50%
56
44


E
12.5%
37.5%
50%
57
40


F
  5%
  45%
50%
49
38


G
  0%
  50%
50%
3
0









As can be seen from these results, cockroaches treated with test composition C-F (containing both mineral oil and ethyl lactate) had significantly higher mortality rates than cockroaches treated with only mineral oil (composition A) or only ethyl lactate (composition G), indicating a synergistic effect when the combination of mineral oil and ethyl lactate is used.
Example 2
In this example, the effectiveness of compositions comprising various concentrations of mineral oil and/or butyl lactate at killing cockroaches was tested.
To begin, compositions comprising mineral oil and/or butyl lactate in the following concentrations were prepared: 100% (wt/wt) mineral oil/0% (wt/wt) butyl lactate; 90% (wt/wt) mineral oil/10% (wt/wt) butyl lactate; 75% (wt/wt) mineral oil/25% (wt/wt) butyl lactate; 50% (wt/wt) mineral oil/50% (wt/wt) butyl lactate; 25% (wt/wt) mineral oil/75% (wt/wt) butyl lactate; 10% (wt/wt) mineral oil/90% (wt/wt) butyl lactate; 0% (wt/wt) mineral oil/100% (wt/wt) butyl lactate. The butyl lactate was obtained from Vertech Biosolvents, Inc., Downers Grove, Ill.
Prior to testing, each composition containing either mineral oil, butyl lactate, or a combination of mineral oil and butyl lactate was diluted by 50% by mixing the composition with acetone in a 1:1 ratio (wt/wt) to reduce viscosity prior to application of the composition to the cockroaches. The amount of mineral oil, butyl lactate, and acetone present in the final compositions (H-N) is set forth below in Table 2.
Tests were performed as described in Example 1. The results are shown in FIG. 2 and Table 2 below.












TABLE 2







Butyl

Males




Mineral
lactate
Acetone
(# dead
Females (#


Composition
oil (wt/wt)
(wt/wt)
(wt/wt)
out of 60)
dead out of 60)




















H
  50%
  0%
50%
3
0


I
  45%
  5%
50%
9
3


J
37.5%
12.5%
50%
37
29


K
  25%
  25%
50%
52
35


L
12.5%
37.5%
50%
38
18


M
  5%
  45%
50%
8
4


N
  0%
  50%
50%
1
4









As can be seen from these results, cockroaches treated with test composition J-L (containing both mineral oil and butyl lactate) had significantly higher mortality rates than cockroaches treated with only mineral oil (composition H) or only butyl lactate (composition N), indicating a synergistic effect when the combination of mineral oil and butyl lactate is used.
Example 3
In this example, the effectiveness of compositions comprising various concentrations of mineral oil and/or hexylene glycol at killing cockroaches was tested.
To begin, compositions comprising mineral oil, hexylene glycol, or a combination of mineral oil and hexylene glycol were prepared. The amount of mineral oil and/or hexylene glycol in each composition is set forth below in Table 3, with the remainder of each composition consisting of acetone.
Tests were generally performed as described in Example 1, except the number of cockroaches (all male) tested for each composition is set forth below in Table 3, and the compositions were not further diluted with acetone in a 1:1 (wt/wt) ratio prior to testing. The results are shown in Table 3 below, which lists the number of cockroaches tested for each composition, the number of dead cockroaches out of the total number of cockroaches tested, the square root percent dead cockroaches, the proportion of dead cockroaches, and the arcsine square root percent dead cockroaches.












TABLE 3








Square

Arcsine


Composition
#
#
root %
Proportion
square


(% wt/wt)
tested
dead
dead
dead
root % dead




















Hexylene glycol
14
1
0.2672612
0.07142857
0


(20%)







Hexylene glycol
12
0
0
0
0


(20%)







Hexylene glycol
13
3
0.4803845
0.23076923
28.7105148


(20%)







Hexylene glycol
14
0
0
0
0


(20%)







Mineral oil (80%)
14
2
0.3779645
0.14285714
22.2076543


Mineral oil (80%)
14
1
0.2672612
0.07142857
15.50135957


Mineral oil (80%)
13
2
0.3922323
0.15384615
23.09346927


Mineral oil (80%)
14
1
0.2672612
0.07142857
15.50135957


Mineral oil
13
11
0.9198662
0.84615385
66.90653073


(60%), hexylene







glycol (20%)







Mineral oil
14
11
0.8864053
0.78571429
62.42495229


(60%), hexylene







glycol (20%)







Mineral oil
14
13
0.9636241
0.92857143
74.49864043


(60%), hexylene







glycol (20%)









As can be seen from these results, cockroaches treated with compositions containing both mineral oil and hexylene glycol had significantly higher mortality rates than cockroaches treated with only mineral oil or only hexylene glycol, indicating a synergistic effect when the combination of mineral oil and hexylene glycol is used.
Example 4
In this example, the effectiveness of compositions comprising various concentrations of mineral oil and/or isopropyl myristate at killing cockroaches was tested.
To begin, compositions comprising mineral oil, isopropyl myristate, or a combination of mineral oil and isopropyl myristate were prepared. The amount of mineral oil and/or isopropyl myristate in each composition is set forth below in Table 4, with the remainder of each composition consisting of acetone.
Tests were generally performed as described in Example 1, except the number of cockroaches (all male) tested for each composition is set forth below in Table 4, and the compositions were not further diluted with acetone in a 1:1 (wt/wt) ratio prior to testing. The results are shown in Table 4 below, which lists the number of cockroaches tested for each composition, the number of dead cockroaches out of the total number of cockroaches tested, the square root percent dead cockroaches, the proportion of dead cockroaches, and the arcsine square root percent dead cockroaches.












TABLE 4








Square




Composition
#
#
root %
Proportion
Arcsine square


(% wt/wt)
tested
dead
dead
dead
root % dead




















Isopropyl myristate
15
1
0.2582
0.06667
14.9632174


(80%)







Isopropyl myristate
17
0
0
0
0


(80%)







Isopropyl myristate
15
1
0.2582
0.06667
14.9632174


(80%)







Isopropyl myristate
12
1
0.28868
0.08333
16.7786549


(80%)







Mineral oil (80%)
15
2
0.36515
0.13333
21.416714


Mineral oil (80%)
17
1
0.24254
0.05882
14.0362435


Mineral oil (80%)
15
2
0.36515
0.13333
21.416714


Mineral oil (80%)
12
0
0
0
0


Mineral oil (80%)
15
2
0.36515
0.13333
21.416714


Mineral oil (40%),
15
6
0.63246
0.4
39.2315205


isopropyl myristate







(40%)







Mineral oil (40%),
16
3
0.43301
0.1875
25.6589063


isopropyl myristate







(40%)







Mineral oil (40%),
15
4
0.5164
0.26667
31.0909304


isopropyl myristate







(40%)







Mineral oil (40%),
12
2
0.40825
0.16667
24.0948425


isopropyl myristate







(40%)







Mineral oil (50%),
15
8
0.7303
0.53333
46.9112769


isopropyl myristate







(30%)







Mineral oil (50%),
16
6
0.61237
0.375
37.7612439


isopropyl myristate







(30%)







Mineral oil (50%),
15
3
0.44721
0.2
26.5650512


isopropyl myristate







(30%)







Mineral oil (50%),
12
4
0.57735
0.33333
35.2643897


isopropyl myristate







(30%)







Mineral oil (60%),
15
4
0.5164
0.26667
31.0909304


isopropyl myristate







(20%)







Mineral oil (60%),
15
7
0.68313
0.46667
43.0887231


isopropyl myristate







(20%)







Mineral oil (60%),
15
4
0.5164
0.26667
31.0909304


isopropyl myristate







(20%)







Mineral oil (60%),
12
3
0.5
0.25
30


isopropyl myristate







(20%)









The combined data for each treatment group is set forth in Table 5 below.










TABLE 5







Average





arcsine



Number of
sq. root


Composition (% wt/wt)
compositions
% dead
Variance


















Isopropyl myristate (80%)
4
11.67627243
61.3258864


Mineral oil (80%)
5
15.6572771
86.82285408


Mineral oil (40%), isopropyl
4
30.01904993
46.70854263


myristate (40%)


Mineral oil (50%), isopropyl
4
36.62549043
70.05079065


myristate (30%)


Mineral oil (60%), isopropyl
4
33.81764598
38.46574917


myristate (20%)









As can be seen from these results, cockroaches treated with compositions containing both mineral oil and isopropyl myristate at all tested concentrations had significantly higher mortality rates than cockroaches treated with only mineral oil or only isopropyl myristate, indicating a synergistic effect when the combination of mineral oil and isopropyl myristate is used.
Example 5
In this example, the effectiveness of compositions comprising various concentrations of mineral oil and/or dioxane at killing cockroaches was tested.
To begin, compositions comprising mineral oil, dioxane, or a combination of mineral oil and dioxane were prepared. The amount of mineral oil and/or dioxane in each composition is set forth below in Table 6, with the remainder of each composition consisting of acetone.
Tests were generally performed as described in Example 1, except the number of cockroaches (all male) tested for each composition is set forth below in Table 6, and the compositions were not further diluted with acetone in a 1:1 (wt/wt) ratio prior to testing. The results are shown in Table 6, which lists the number of cockroaches tested for each composition, the number of dead cockroaches out of the total number of cockroaches tested, the square root percent dead cockroaches, the proportion of dead cockroaches, and the arcsine square root percent dead cockroaches.












TABLE 6





Composition


Square root %
Proportion
Arcsine square


(% wt/wt)
# tested
# dead
dead
dead
root % dead




















Dioxane (50%)
10
0
0
0
0


Dioxane (50%)
14
0
0
0
0


Dioxane (50%)
14
0
0
0
0


Dioxane (50%)
12
0
0
0
0


Dioxane (50%)
13
1
0.277350098
0.07692308
16.10211375


Mineral oil (80%)
13
1
0.277350098
0.07692308
16.10211375


Mineral oil (80%)
14
2
0.377964473
0.14285714
22.2076543


Mineral oil (80%)
14
2
0.377964473
0.14285714
22.2076543


Mineral oil (80%)
14
1
0.267261242
0.07142857
15.50135957


Mineral oil (80%)
13
2
0.39223227
0.15384615
23.09346927


Mineral oil (40%),
14
10
0.845154255
0.71428571
57.68846676


dioxane (40%)







Mineral oil (40%),
14
11
0.88640526
0.78571429
62.42495229


dioxane (40%)







Mineral oil (40%),
14
11
0.88640526
0.78571429
62.42495229


dioxane (40%)







Mineral oil (40%),
15
9
0.774596669
0.6
50.76847952


dioxane (40%)







Mineral oil (40%),
13
12
0.960768923
0.92307692
73.89788625


dioxane (40%)









As can be seen from these results, cockroaches treated with compositions containing both mineral oil and dioxane had significantly higher mortality rates than cockroaches treated with only mineral oil or only dioxane, indicating a synergistic effect when the combination of mineral oil and dioxane is used.
Example 6
In this example, the effectiveness of compositions comprising various concentrations of mineral oil and/or d-limonene at killing cockroaches was tested.
To begin, compositions comprising mineral oil, d-limonene, or a combination of mineral oil and d-limonene were prepared. The amount of mineral oil and/or d-limonene in each composition is set forth below in Table 7, with the remainder of each composition consisting of acetone.
Tests were generally performed as described in Example 1, except the number of cockroaches (all male) tested for each composition is set forth below in Table 7, and the compositions were not further diluted with acetone in a 1:1 (wt/wt) ratio prior to testing. The results are shown in Table 7, which lists the number of cockroaches tested for each composition, the number of dead cockroaches out of the total number of cockroaches tested, the square root percent dead cockroaches, the proportion of dead cockroaches, and the arcsine square root percent dead cockroaches.












TABLE 7







#
Square root %
Proportion
Arcsine square


Composition (% wt/wt)
# tested
dead
dead
dead
root % dead




















d-limonene (40%)
14
1
0.267261242
0.0714286
15.50135957


d-limonene (40%)
12
0
0
0
0


d-limonene (40%)
15
2
0.365148372
0.1333333
21.41671403


d-limonene (40%)
14
2
0.377964473
0.1428571
22.2076543


Mineral oil (80%)
14
2
0.377964473
0.1428571
22.2076543


Mineral oil (80%)
14
1
0.267261242
0.0714286
15.50135957


Mineral oil (80%)
13
2
0.39223227
0.1538462
23.09346927


Mineral oil (80%)
14
1
0.267261242
0.0714286
15.50135957


Mineral oil (40%), d-
14
6
0.654653671
0.4285714
40.89339465


limonene (40%)







Mineral oil (40%), d-
13
5
0.620173673
0.3846154
38.3288181


limonene (40%)







Mineral oil (40%), d-
14
12
0.9258201
0.8571429
67.7923457


limonene (40%)







Mineral oil (40%), d-
14
7
0.707106781
0.5
45


limonene (40%)









The combined data for each treatment group is set forth in Table 8 below.










TABLE 8





Composition
Number of
Average arcsine



(% wt/wt)
compositions
sq. root % dead
Variance


















d-limonene (40%)
4
14.78145
106.0618


Mineral oil (80%)
4
19.076
17.16779


Mineral oil (40%),
4
48.00363
181.5903


d-limonene (40%)









As can be seen from these results, cockroaches treated with compositions containing both mineral oil and d-limonene had significantly higher mortality rates than cockroaches treated with only mineral oil or only d-limonene, indicating a synergistic effect when the combination of mineral oil and d-limonene is used.
Example 7
In this example, the effectiveness of compositions comprising various types of mineral oil at killing cockroaches was tested.
To begin, compositions comprising one of three different types of mineral oil in varying concentrations were prepared. The mineral oils used in this example were PD-23 (Sample No. 88446, 1997, available from Chemtura Corporation, Middlebury, Conn.), which is a low viscosity (e.g., about 2.6 cSt at 40° C. or about 34 SUS at 100° F. (38° C.)) petroleum distillate; PD-25 (Sample No. 88447, available from Chemtura Corporation, Middlebury, Conn.), which is a medium viscosity (e.g., about 3.5 cSt at 40° C. or about 39 SUS at 100° F. (38° C.)) petroleum distillate; and PD-28 (Sample No. 88448, 1997, available from Chemtura Corporation, Middlebury, Conn.), which is a relatively high viscosity (e.g., about 4.2 cSt at 40° C. or about 39 SUS at 100° F. (38° C.)) petroleum distillate. The amount of each type of mineral oil in each composition is set forth below in Table 9, with the remainder of the composition comprising ethanol.
Tests were generally performed as described in Example 1, except 2 μl of the compositions were applied to each cockroach, the number of cockroaches (all male) tested for each diluted composition is set forth below in Table 9, and the compositions were not further diluted with acetone in a 1:1 (wt/wt) ratio prior to testing. The results are shown in Table 9.











TABLE 9







Composition





(% wt/wt)
# tested
# dead




















PD-23 (50%)
10
10



PD-23 (20%)
10
2



PD-23 (20%)
9
2



PD-25 (50%)
9
8



PD-25 (20%)
11
0



PD-28 (50%)
9
5



PD-28 (20%)
10
0










As can be seen from these results, compositions containing the higher concentration of mineral oil (i.e., the 50% compositions) were more effective against adult German cockroaches than the lower concentration compositions (i.e., the 20% compositions). Of the 20% compositions, only the PD-23 had any effect against the cockroaches. These results indicate that the lightest weight mineral oil used in these tests, PD-23, was the most active against adult German cockroaches.
Example 8
In this embodiment, an aerosol pesticidal composition of the present disclosure was prepared. The ingredients and amounts used to prepare the composition are set forth in Table 10 below.










TABLE 10








Amount



Ingredient
(wt/wt %)



















Mineral oil (PD-23, available
56.20%



from Chemtura)



Ethyl lactate
14.95%



Isopropyl myristate
24.00%



Geraniol
2.00%



Carbon dioxide
2.85%










The composition was prepared by mixing the mineral oil, ethyl lactate, isopropyl myristate and geraniol together until homogenous. The resulting composition was placed in an aerosol can. The lid and actuator of the aerosol can were sealed onto the top of the can. The carbon dioxide was introduced into the can through the actuator to pressurize the can. The resulting product can be used as an aerosol spray pesticidal composition.
Example 9
In this example, various mineral oils and alcohols were tested to determine, for cockroaches, the LD50 and LD10 for each.
PD23 and PD28 mineral oils were obtained from Sonneborn LLC, Mahwah, N.J. The physical properties of these oils are shown in Table 11. Each mineral oil was tested to determine the LD50 and LD10 (Table 12).










TABLE 11





PROPERTY
PD23
PD28
Test Method


















Specific gravity 60/60
0.800
0.823
ASTM D-287


Viscosity SUS @ 100° F.
34
39
ASTM D-2161


(38° C.)


Viscosity cSt @ 40° C.
2.6
4.2
ASTM-D-445


Pour point ° F. (° C.)
0 (−18)
−40 (−40)
ASTM D-97


Distillation range, ° F.


Ibp
452
526


 50%
486
568


 95%
514
614


100%
533
625


Molecular weight
220
245









The alcohols tested comprise C1-C14 saturated straight chain alcohols, and alcohols selected from the group consisting of isopropyl alcohol, 2-butanol, isobutyl alcohol, tertiary butyl alcohol, 2-butoxyethanol, 2-phenylethanol and diacetone alcohol. The tested alcohols were obtained from Sigma-Aldrich Corp., St. Louis, Mo. Each alcohol was tested to determine the LD50 and LD10 (Table 12). The dose-response mortality data were analyzed using probit analysis (PoloPlus©, LeOra Software Co., Petaluma Calif., 2003) to estimate LD50 and LD10 values and their 95% confidence intervals.











TABLE 12





Test Substance
LD50 mg/insect
LD10 mg/insect

n


(CAS number)
(95% CI)
(95% CI)
Slope (+/−SE)
(sample size)



















PD23-mineral oil
1.453
0.754
4.500 (0.360)
394


(8042-47-5)
(1.303-1.629)
(0.632-0.863)


PD28-mineral oil
2.013
1.463
9.259 (1.204)
249


(8042-47-5)
(1.916-2.105)
(1.285-1.588)


Methanol
>7.00 
Estimated at ~3.000
n/a
151


(67-56-1)


Ethanol
2.361
1.760
10.037 (1.285) 
215


(64-17-5)
(2.084-2.659)
(1.255-2.014)


1-propanol
0.557
0.472
17.756 (2.034) 
248


(71-23-8)
(0.527-0.582)
(0.414-0.504)


1-butanol
1.018
0.877
19.808 (3.556) 
143


(71-36-3)
(0.980-1.070)
(0.814-0.917)


1-hexanol
0.718
0.452
6.392 (0.869)
157


(111-27-3)
(0.651-0.793)
(0.371-0.514)


1-heptanol
0.791
0.462
5.502 (0.951)
154


(111-70-6)
(0.704-0.899)
(0.324-0.549)


1-octanol
0.524
0.267
4.375 (0.720)
149


(111-87-5)
(0.390-0.635)
(0.116-0.367)


1-nonanol
0.448
0.207
3.832 (0.757)
84


(143-08-08)
(0.296-0.633)
(0.051-0.309)


1-decanol
0.421
0.275
6.931 (1.023)
272


(112-30-1)
((0.365-0.479)
(0.151-0.331)


1-undecanol
0.406
0.265
6.956 (1.013)
165


(112-42-5)
(0.373-0.444)
(0.221-0.298)


1-dodecanol
0.357
0.245
7.809 (1.350)
135


(112-53-8)
(0.304-0.412)
(0.146-0.292)


1-tetradecanol
1.745
1.193
7.756 (1.268)
131


(112-72-1)
(1.568-1.948)
(0.902-1.369)


Isopropyl alcohol
1.172
0.676
5.370 (0.701)
195


(67-63-0)
(1.014-1.394)
(0.462-0.814)


2-butanol
1.188
0.881
9.873 (1.479)
111


(78-92-2)
(1.058-1.369)
(0.709-0.997)


isobutyl alcohol
0.517
0.253
4.129 (0.452)
299


(78-83-1)
(0.426-0.644)
(0.146-0.326)


tertiary butyl
0.716
0.553
11.392 (2.147) 
112


alcohol
(0.634-1.004)
(0.385-0.625)


(75-65-0)


2-butoxyethanol
0.377
0.256
7.613 (1.200)
157


(111-76-2)
(0.349-0.413)
(0.217-0.282)


2-phenylethanol
0.169
0.075
3.628 (0.546)
142


(60-12-8)
(0.114-0.327)
(0.015-0.113)


Diacetone alcohol
0.483
0.255
4.617 (0.596)
171


(123-42-2)
(0.390-0.591)
(0.151-0.329)









Example 10
In this example, the effectiveness of compositions comprising various alcohols and/or mineral oil at killing cockroaches was tested.
The compositions comprising alcohol and/or mineral oil are described in Table 13. The tests were performed as described in Example 1.










TABLE 13







#
Pro-




dead
portion



#
at
dead


Composition
treated
24 h
at 24 h


















diacetone alcohol (0.4 mg) + PD23 (0.4 mg)
11
11
1.000


diacetone alcohol (0.4 mg) + PD23 (0.4 mg)
11
10
0.909


diacetone alcohol (0.4 mg) + PD23 (0.4 mg)
12
11
0.917


diacetone alcohol (0.3 mg) + PD23 (0.4 mg)
13
12
0.923


diacetone alcohol (0.3 mg) + PD23 (0.4 mg)
13
11
0.846


diacetone alcohol (0.3 mg) + PD23 (0.4 mg)
14
12
0.857


diacetone alcohol (0.3 mg)
13
0
0.000


diacetone alcohol (0.3 mg)
13
0
0.000


diacetone alcohol (0.3 mg)
14
1
0.071


methanol (1.0 mg) + PD23 (0.4 mg)
14
1
0.071


methanol (1.0 mg) + PD23 (0.4 mg)
14
0
0.000


methanol (1.0 mg) + PD23 (0.4 mg)
14
1
0.071


methanol (3.0 mg) + PD23 (0.4 mg)
12
4
0.333


methanol (3.0 mg) + PD23 (0.4 mg)
14
4
0.286


methanol (3.0 mg) + PD23 (0.4 mg)
12
5
0.417


methanol (3.0 mg)
14
0
0.000


methanol (3.0 mg)
12
0
0.000


methanol (3.0 mg)
13
1
0.077


ethanol (1.0 mg) + PD23 (0.4 mg)
14
1
0.071


ethanol (1.0 mg) + PD23 (0.4 mg)
13
2
0.154


ethanol (1.0 mg) + PD23 (0.4 mg)
13
4
0.308


ethanol (1.25 mg) + PD23 (0.4 mg)
12
5
0.417


ethanol (1.25 mg) + PD23 (0.4 mg)
12
3
0.250


ethanol (1.25 mg) + PD23 (0.4 mg)
13
3
0.231


ethanol (1.25 mg)
13
0
0.000


ethanol (1.25 mg)
12
1
0.083


ethanol (1.25 mg)
12
0
0.000


1-propanol (0.6 mg) + PD23 (0.40 mg)
12
12
1.000


1-propanol (0.6 mg) + PD23 (0.40 mg)
11
11
1.000


1-propanol (0.6 mg) + PD23 (0.40 mg)
10
10
1.000


1-propanol (0.50 mg) + PD23 (0.40 mg)
12
12
1.000


1-propanol (0.50 mg) + PD23 (0.40 mg)
13
13
1.000


1-propanol (0.50 mg) + PD23 (0.40 mg)
13
13
1.000


1-propanol (0.45 mg) + PD23 (0.40 mg)
12
10
0.833


1-propanol (0.45 mg) + PD23 (0.40 mg)
13
13
1.000


1-propanol (0.45 mg) + PD23 (0.40 mg)
12
12
1.000


1-propanol (0.45 mg)
12
1
0.083


1-propanol (0.45 mg)
12
0
0.000


1-propanol (0.45 mg)
12
0
0.000


Isopropyl alcohol (0.6 mg) + PD23 (0.4 mg)
12
3
0.250


Isopropyl alcohol (0.6 mg) + PD23 (0.4 mg)
14
4
0.286


Isopropyl alcohol (0.6 mg) + PD23 (0.4 mg)
12
3
0.250


Isopropyl alcohol (0.6 mg)
12
0
0.000


Isopropyl alcohol (0.6 mg)
14
0
0.000


Isopropyl alcohol (0.6 mg)
12
0
0.000


Isopropyl alcohol (0.8 mg) + PD23 (0.4 mg)
12
3
0.250


Isopropyl alcohol (0.8 mg) + PD23 (0.4 mg)
13
7
0.538


Isopropyl alcohol (0.8 mg) + PD23 (0.4 mg)
12
10
0.833


1-butanol (0.8 mg) + PD23 (0.4 mg)
13
8
0.615


1-butanol (0.8 mg) + PD23 (0.4 mg)
13
10
0.769


1-butanol (0.8 mg) + PD23 (0.4 mg)
13
10
0.769


1-butanol (0.8 mg)
12
0
0.000


1-butanol (0.8 mg)
13
0
0.000


1-butanol (0.8 mg)
10
1
0.100


2-butanol (0.8 mg) + PD23 (0.4 mg)
12
1
0.083


2-butanol (0.8 mg) + PD23 (0.4 mg)
14
0
0.000


2-butanol (0.8 mg) + PD23 (0.4 mg)
12
3
0.250


2-butanol (0.8 mg)
13
0
0.000


2-butanol (0.8 mg)
13
0
0.000


2-butanol (0.8 mg)
12
1
0.083


t-butyl alcohol (0.5 mg) + PD23 (0.4 mg)
10
3
0.300


t-butyl alcohol (0.5 mg) + PD23 (0.4 mg)
11
3
0.273


t-butyl alcohol (0.5 mg) + PD23 (0.4 mg)
12
8
0.667


t-butyl alcohol (0.5 mg)
12
0
0.000


t-butyl alcohol (0.5 mg)
11
0
0.000


t-butyl alcohol (0.5 mg)
10
0
0.000


t-butyl alcohol (0.5 mg)
11
2
0.182


isobutyl alcohol (0.50 mg) + PD23 (0.40 mg)
14
11
0.786


isobutyl alcohol (0.50 mg) + PD23 (0.40 mg)
13
13
1.000


isobutyl alcohol (0.50 mg) + PD23 (0.40 mg)
15
15
1.000


isobutyl alcohol (0.50 mg)
14
1
0.071


isobutyl alcohol (0.20 mg)
13
0
0.000


isobutyl alcohol (0.20 mg)
12
0
0.000


isobutyl alcohol (0.20 mg)
13
1
0.077


isobutyl alcohol (0.20 mg) + PD23 (0.40 mg)
14
2
0.143


isobutyl alcohol (0.20 mg) + PD23 (0.40 mg)
13
3
0.231


isobutyl alcohol (0.20 mg) + PD23 (0.40 mg)
15
11
0.733


isobutyl alcohol (0.20 mg) + PD23 (0.40 mg)
12
7
0.583


1-hexanol (0.4 mg) + PD23 (0.40 mg)
13
13
1.000


1-hexanol (0.4 mg) + PD23 (0.40 mg)
12
12
1.000


1-hexanol (0.4 mg) + PD23 (0.40 mg)
12
12
1.000


1-hexanol (0.4 mg)
12
1
0.083


1-hexanol (0.4 mg)
12
1
0.083


1-hexanol (0.4 mg)
12
1
0.083


1-heptanol (0.4 mg) + PD23 (0.40 mg)
12
12
1.000


1-heptanol (0.4 mg) + PD23 (0.40 mg)
12
11
0.917


1-hexanol (0.4 mg) + PD23 (0.40 mg)
12
12
1.000


1-heptanol (0.4 mg)
12
1
0.083


1-heptanol (0.4 mg)
12
0
0.000


1-heptanol (0.4 mg)
12
0
0.000


1-octanol (0.2 mg) + PD23 (0.40 mg)
12
3
0.250


1-octanol (0.2 mg) + PD23 (0.40 mg)
12
3
0.250


1-octanol (0.2 mg) + PD23 (0.40 mg)
12
3
0.250


1-octanol (0.2 mg)
13
2
0.154


1-octanol (0.2 mg)
12
0
0.000


1-octanol (0.2 mg)
12
0
0.000


1-nonanol (0.2 mg) + PD23 (0.40 mg)
12
4
0.333


1-nonanol (0.2 mg) + PD23 (0.40 mg)
12
3
0.250


1-nonanol (0.2 mg) + PD23 (0.40 mg)
12
1
0.083


1-nonanol (0.2 mg)
12
0
0.000


1-nonanol (0.2 mg)
16
1
0.063


1-nonanol (0.2 mg)
13
0
0.000


1-decanol (0.2 mg) + PD23 (0.40 mg)
12
0
0.000


1-decanol (0.2 mg) + PD23 (0.40 mg)
12
1
0.083


1-decanol (0.2 mg) + PD23 (0.40 mg)
12
0
0.000


1-decanol (0.2 mg)
12
0
0.000


1-decanol (0.2 mg)
12
0
0.000


1-decanol (0.2 mg)
13
1
0.077


1-undecanol (0.25 mg) + PD23 (0.40 mg)
12
0
0.000


1-undecanol (0.25 mg) + PD23 (0.40 mg)
13
1
0.077


1-undecanol (0.25 mg) + PD23 (0.40 mg)
12
0
0.000


1-undecanol (0.25 mg)
13
2
0.154


1-undecanol (0.25 mg)
12
0
0.000


1-undecanol (0.25 mg)
13
2
0.154


1-dodecanol (0.2 mg) + PD23 (0.40 mg)
13
2
0.154


1-dodecanol (0.2 mg) + PD23 (0.40 mg)
12
3
0.250


1-dodecanol (0.2 mg) + PD23 (0.40 mg)
12
5
0.417


1-dodecanol (0.2 mg)
13
2
0.154


1-dodecanol (0.2 mg)
13
0
0.000


1-dodecanol (0.2 mg)
13
1
0.077


1-tetradecanol (1.00 mg) + PD23 (0.40 mg)
12
1
0.083


1-tetradecanol (1.00 mg) + PD23 (0.40 mg)
12
0
0.000


1-tetradecanol (1.00 mg) + PD23 (0.40 mg)
12
1
0.083


1-tetradecanol (1.00 mg)
12
1
0.083


1-tetradecanol (1.00 mg)
12
1
0.083


1-tetradecanol (1.00 mg)
13
2
0.154


2-phenylethanol (0.1 mg) + PD23 (0.4 mg)
12
7
0.583


2-phenylethanol (0.1 mg) + PD23 (0.4 mg)
14
14
1.000


2-phenylethanol (0.1 mg) + PD23 (0.4 mg)
13
10
0.769


2-phenylethanol (0.1 mg)
12
1
0.083


2-phenylethanol (0.1 mg)
12
1
0.083


2-phenylethanol (0.1 mg)
13
0
0.000


2-phenylethanol (0.1 mg)
10
3
0.300


2-butyoxyethanol (0.3 mg) + PD23 (0.4 mg)
12
12
1.000


2-butyoxyethanol (0.3 mg) + PD23 (0.4 mg)
12
12
1.000


2-butyoxyethanol (0.3 mg) + PD23 (0.4 mg)
12
12
1.000


2-butyoxyethanol (0.2 mg) + PD23 (0.4 mg)
13
6
0.462


2-butyoxyethanol (0.2 mg) + PD23 (0.4 mg)
13
6
0.462


2-butyoxyethanol (0.2 mg) + PD23 (0.4 mg)
13
2
0.154


2-butyoxyethanol (0.2 mg)
14
0
0.000


2-butyoxyethanol (0.2 mg)
13
0
0.000


2-butyoxyethanol (0.2 mg)
13
0
0.000









The composite data for certain compositions is presented below (Table 14), also including the calculated proportion of cockroaches dead at 24 hours for the group treated with alcohol alone and for the group treated with the composition comprising PD23 and alcohol. The difference between the proportion of dead cockroaches in the group treated with the composition comprising PD23 and alcohol and the group treated with alcohol alone was calculated, and is also presented in Table 14. Here, the increase in mortality indicates a synergistic effect with the combination compared to the alcohol or mineral oil alone, with a higher difference indicating a greater synergy. The straight chain saturated alcohols with chain lengths of C3-C7 demonstrated the greatest increase, or difference, in mortality when combined with PD23 mineral oil, as compared to the other alcohols tested.












TABLE 14










Significance







(* p < 0.05;



Total #


Difference
** p < 0.01;


Individual or
cockroaches
# dead
Proportion
(combination-
ns = not


combination treatment
treated
at 24 h
dead at 24 h
alcohol)
significant)




















PD23 - mineral oil
91
0
0
n/a



(0.40 mg)







methanol (3.0 mg)
39
1
0.026




methanol (3.0 mg) +
38
13
0.342
0.316
*


PD23 (0.40 mg)







ethanol (1.25 mg)
37
1
0.027




ethanol (1.25 mg) +
37
11
0.297
0.270
*


PD23 (0.40 mg)







1-propanol (0.45 mg)
36
1
0.028




1-propanol (0.45 mg) +
37
35
0.946
0.918
**


PD23 (0.40 mg)







1-butanol (0.8 mg)
35
1
0.029




1-butanol (0.8 mg) +
39
28
0.718
0.689
**


PD23 (0.40 mg)







1-hexanol (0.4 mg)
36
3
0.083




1-hexanol (0.4 mg) +
37
37
1.000
0.917
**


PD23 (0.40 mg)







1-heptanol (0.4 mg)
36
1
0.028




1-heptanol (0.4 mg) +
36
35
0.972
0.944
**


PD23 (0.40 mg)







1-octanol (0.2 mg)
37
2
0.054




1-octanol (0.2 mg) +
36
9
0.250
0.196
*


PD23 (0.40 mg)







1-nonanol (0.2 mg)
41
1
0.024




1-nonanol (0.2 mg) +
36
8
0.222
0.198
*


PD23 (0.40 mg)







1-decanol (0.2 mg)
37
1
0.027




1-decanol (0.2 mg) +
36
1
0.028
0.001
ns


PD23 (0.40 mg)







1-undecanol (0.25 mg)
38
4
0.105




1-undecanol (0.25 mg) +
37
1
0.027
−0.078
ns


PD23 (0.40 mg)







1-dodecanol (0.2 mg)
39
3
0.077




1-dodecanol (0.2 mg) +
37
10
0.270
0.193
ns


PD23 (0.40 mg)







1-tetradecanol (1.0 mg)
37
4
0.108




1-tetradecanol (1.0 mg) +
36
2
0.056
−0.052
ns


PD23 (0.40 mg)







diacetone alcohol (0.30 mg)
40
1
0.025




diacetone alcohol (0.30 mg) +
40
35
0.875
0.850
**


PD23 (0.40 mg)







Isopropyl alcohol (0.60 mg)
38
0
0.000




Isopropyl alcohol (0.60 mg) +
38
10
0.263
0.263
*


PD23 (0.40 mg)







2-butanol (0.80 mg)
38
1
0.026




2-butanol (0.80 mg) +
38
4
0.105
0.079
ns


PD23 (0.40 mg)







t-butyl alcohol (0.50 mg)
44
2
0.045




t-butyl alcohol (0.50 mg) +
33
14
0.424
0.379
*


PD23 (0.40 mg)







isobutyl alcohol (0.20 mg)
38
1
0.026




isobutyl alcohol (0.20 mg) +
38
23
0.605
0.579
**


PD23 (0.40 mg)







2-phenylethanol (0.10 mg)
47
5
0.106




2-phenylethanol (0.10 mg) +
39
31
0.795
0.689
**


PD23 (0.40 mg)







2-butyoxyethanol (0.20 mg)
40
0
0.000




2-butyoxyethanol (0.20 mg) +
36
14
0.389
0.389
*


PD23 (0.40 mg)









Example 11
In this embodiment, an aerosol pesticidal composition of the present disclosure was prepared. The ingredients and amounts used to prepare the composition are set forth in Table 15 below.










TABLE 15







Ingredient
Amount (wt/wt %)



















Mineral oil (PD-23, available
43.13%



from Chemtura)



Ethyl lactate
14.95%



Isopropyl myristate
30.00%



Geraniol
6.00%



Nerol
2.57%



Lemongrass oil
0.50%



Carbon dioxide
2.85%










The composition was prepared by mixing a geraniol/nerol composition with the mineral oil, ethyl lactate, isopropyl myristate and lemongrass oil until homogenous. The resulting composition was placed in an aerosol can. The lid and actuator of the aerosol can were sealed onto the top of the can. The carbon dioxide was introduced into the can through the actuator to pressurize the can. The resulting product can be used as an aerosol pesticidal composition.
Example 12
In this example, the effectiveness of compositions comprising various compounds and/or mineral oil at killing cockroaches was tested.
The compounds tested are shown in Table 16. The tests were performed as described in Example 1.










TABLE 16







# dead at
Proportion


Composition
# treated
24 h
dead at 24 hr


















gamma butyrolactone (96-48-0) (0.25 mg)
7
3
0.429


gamma butyrolactone (96-48-0) (0.25 mg)
10
3
0.300


gamma butyrolactone (96-48-0) (0.25 mg)
10
5
0.500


gamma butyrolactone (0.25 mg) + PD23 (0.40 mg)
8
8
1.000


gamma butyrolactone (0.25 mg) + PD23 (0.40 mg)
10
9
0.900


gamma butyrolactone (0.25 mg) + PD23 (0.40 mg)
11
10
0.909


nitromethane (75-52-5) (0.70 mg)
11
0
0.000


nitromethane (75-52-5) (0.70 mg)
12
0
0.000


nitromethane (75-52-5) (0.70 mg)
11
0
0.000


nitromethane (75-52-5) (0.80 mg)
7
0
0.000


nitromethane (75-52-5) (0.80 mg)
10
2
0.200


nitromethane (75-52-5) (0.80 mg)
11
3
0.273


Nitromethane (0.70 mg) + PD23 (0.40 mg)
11
6
0.545


Nitromethane (0.70 mg) + PD23 (0.40 mg)
11
7
0.636


Nitromethane (0.70 mg) + PD23 (0.40 mg)
11
7
0.636


Nitromethane (0.80 mg) + PD23 (0.40 mg)
7
7
1.000


Nitromethane (0.80 mg) + PD23 (0.40 mg)
10
9
0.900


Nitromethane (0.80 mg) + PD23 (0.40 mg)
11
7
0.636


Di(ethylene) glycol (111-46-6) (0.80 mg)
10
0
0.000


Di(ethylene) glycol (111-46-6) (0.80 mg)
10
0
0.000


Di(ethylene) glycol (111-46-6) (0.80 mg)
13
6
0.462


Di(ethylene) glycol (0.80 mg) + PD23 (0.40 mg)
10
0
0.000


Acetophenone (98-86-2) (0.10 mg)
10
0
0.000


Acetophenone (98-86-2) (0.10 mg)
10
0
0.000


Acetophenone (98-86-2) (0.10 mg)
10
0
0.000


Acetophenone (98-86-2) (0.10 mg) + PD23 (0.40 mg)
10
3
0.300


Acetophenone (98-86-2) (0.10 mg) + PD23 (0.40 mg)
10
8
0.800


Acetophenone (98-86-2) (0.10 mg) + PD23 (0.40 mg)
10
10
1.000


diethyl ether (60-29-7) (2.00 mg)
11
0
0.000


diethyl ether (60-29-7) (2.00 mg)
10
0
0.000


diethyl ether (2.00 mg) + PD23 (0.40 mg)
10
1
0.000


Isopropyl acetate (108-21-4) (1.00 mg)
10
1
0.100


Isopropyl acetate (108-21-4) (1.00 mg)
10
2
0.200


Isopropyl acetate (108-21-4) (1.00 mg) + PD23 (0.40 mg)
10
0
0.000


2-butanone (methyl ethyl ketone) (78-93-3) (2.00 mg)
13
0
0.000


2-butanone (methyl ethyl ketone) (78-93-3) (2.00 mg)
12
2
0.167


2-butanone (methyl ethyl ketone) (78-93-3) (2.00 mg)
11
1
0.091


2-butanone (methyl ethyl ketone) (78-93-3) (2.00 mg) +
10
3
0.300


PD23 (0.40 mg)


2-butanone (methyl ethyl ketone) (78-93-3) (2.00 mg) +
12
2
0.167


PD23 (0.40 mg)


2-butanone (methyl ethyl ketone) (78-93-3) (2.00 mg) +
12
2
0.167


PD23 (0.40 mg)


Triacetin (102-76-1) (2.00 mg)
10
0
0.000


Triacetin (102-76-1) (2.00 mg)
10
1
0.100


Triacetin (102-76-1) (2.00 mg)
10
0
0.000


Triacetin (102-76-1) (2.0 mg) + PD23 (0.40 mg)
11
6
0.545


Triacetin (102-76-1) (2.0 mg) + PD23 (0.40 mg)
10
8
0.800


Triacetin (102-76-1) (2.0 mg) + PD23 (0.40 mg)
10
8
0.800


Pyridine (110-86-1) (0.10 mg)
11
0
0.000


Pyridine (110-86-1) (0.10 mg)
10
0
0.000


Pyridine (110-86-1) (0.10 mg)
10
1
0.100


Pyridine (110-86-1) (0.10 mg) + PD23 (0.40 mg)
10
10
1.000


Pyridine (110-86-1) (0.10 mg) + PD23 (0.40 mg)
10
10
1.000


Pyridine (110-86-1) (0.10 mg) + PD23 (0.40 mg)
10
10
1.000


Chloroform anhydrous (67-66-3) (1.00 mg)
10
1
0.100


Chloroform anhydrous (67-66-3) (1.00 mg)
10
0
0.000


Chloroform anhydrous (67-66-3) (1.00 mg) + PD23 (0.40 mg)
10
0
0.000


Methyl isobutyl ketone (108-10-1) (1.00 mg)
10
1
0.100


Methyl isobutyl ketone (108-10-1) (1.00 mg)
11
0
0.000


Methyl isobutyl ketone (108-10-1) (1.00 mg) + PD23
10
1
0.100


(0.40 mg)


Tetrahydrofuran (109-99-9) (0.80 mg)
10
3
0.300


Tetrahydrofuran (109-99-9) (0.80 mg) + PD 23 (0.40 mg)
10
0
0.000


2-ethoxyethanol (ethyl cellosolve) (110-80-5) (0.60 mg)
10
1
0.100


2-ethoxyethanol (ethyl cellosolve) (110-80-5) (0.60 mg)
10
0
0.000


2-ethoxyethanol (ethyl cellosolve) (110-80-5) (0.60 mg)
10
0
0.000


2-ethoxyethanol (ethyl cellosolve) (110-80-5) (0.60 mg) +
10
8
0.800


0.40 mg PD23


2-ethoxyethanol (ethyl cellosolve) (110-80-5) (0.60 mg) +
10
5
0.500


0.40 mg PD23


2-ethoxyethanol (ethyl cellosolve) (110-80-5) (0.60 mg) +
11
7
0.636


0.40 mg PD23


n-methyl pyrrolidone (872-50-4) (0.10 mg)
10
5
0.500


n-methyl pyrrolidone (872-50-4) (0.05 mg)
10
1
0.100


n-methyl pyrrolidone (872-50-4) (0.10 mg) + PD23 (0.40 mg)
10
7
0.700


n-methyl pyrrolidone (872-50-4) (0.05 mg) + PD23 (0.40 mg)
12
1
0.083


Polyethylene glycol 200 Sigma (25322-68-3) (0.80 mg)
10
1
0.100


Polyethylene glycol 200 Sigma (25322-68-3) (0.80 mg)
10
0
0.000


Polyethylene glycol 200 Sigma (25322-68-3) (0.80 mg)
12
4
0.333


Polyethylene glycol 200 Sigma (0.80 mg) + PD23 (0.40 mg)
10
3
0.300


Dimethoxymethane (methylal) (109-87-5) (2.00 mg)
12
0
0.000


Dimethoxymethane (methylal) (109-87-5) (2.00 mg)
10
0
0.000


Dimethoxymethane (methylal) (109-87-5) (2.00 mg) +
10
1
0.100


PD23 (0.40 mg)


Methyl chloroform (71-55-6) (2.00 mg)
11
1
0.091


Methyl chloroform (71-55-6) (2.00 mg)
10
1
0.100


Methyl chloroform (71-55-6) (2.00 mg) + PD23 (0.40 mg)
10
0
0.000


Diisopropyl biphenyl Nu-solv (69009-90-1) (0.80 mg)
10
0
0.000


Diisopropyl biphenyl Nu-solv (69009-90-1) (0.80 mg) +
10
2
0.200


PD23 (0.40 mg)


Hexanes (110-54-3) (0.80 mg)
10
1
0.100


Hexanes (0.80 mg) + PD23 (0.40 mg)
10
0
0.000


Methyl t-butyl ether (1634-04-4) (2.00 mg)
12
2
0.167


Methyl t-butyl ether (1634-04-4) (2.00 mg)
10
3
0.300


Methyl t-butyl ether (1634-04-4) (2.00 mg) + PD23 (0.40 mg)
10
2
0.200


Dichloromethane (methylene chloride) (75-09-02) (1.50 mg)
10
0
0.000


Dichloromethane (methylene chloride) (1.50 mg) +
10
0
0.000


PD23 (0.40 mg)


Toluene (108-88-3) (0.90 mg)
10
0
0.000


Toluene (108-88-3) (0.90 mg) + PD23 (0.40 mg)
10
1
0.100









The composite data for certain compositions is presented below (Table 17), also including the calculated proportion of cockroaches dead at 24 hours for the group treated with the specific compounds alone and for the group treated with the composition comprising PD23 and the compound. The difference between the proportion of dead cockroaches in the group treated with the composition comprising PD23 and the compounds and the group treated with the compounds alone was calculated, and is also presented in Table 17. Here, the increase in mortality indicates a synergistic effect with the combination compared to the tested compound or mineral oil alone, with a higher difference indicating a greater synergy. γ-butyrolactone, nitromethane, acetophenone, triacetin, pyridine and 2-ethoxyethanol demonstrated the greatest increase in mortality when combined with PD23 mineral oil, as compared to the other compounds tested.












TABLE 17










Significance







(* p < 0.05;



Total # of


Difference
** p < 0.01;


Individual or combination
cockroaches
# dead
Proportion
(combination-
ns = not


treatment
treated
at 24 h
dead at 24 h
solvent)
significant)




















PD23-mineral oil (0.40 mg)
91
0
0.000
n/a



gamma butyrolactone (96-
27
11
0.407




48-0) (0.25 mg)







gamma butyrolactone (96-
29
27
0.931
0.524
**


48-0) (0.25 mg) + PD23







(0.40 mg)







nitromethane (75-52-5)
34
0
0.000




(0.70 mg)







nitromethane (75-52-5)
33
20
0.606
0.606
**


(0.70 mg) + PD23 (0.40 mg)







nitromethane (75-52-5)
28
5
0.179




(0.80 mg)







nitromethane (75-52-5)
28
23
0.821
0.643
**


(0.80 mg) + PD23 (0.40 mg)







Di(ethylene) glycol (111-46-
33
6
0.182




6) (0.80 mg)







Di(ethylene) glycol (111-46-
10
0
0.000
−0.182
ns


6) (0.80 mg) + PD23 (0.40 mg)







Acetophenone (98-86-2)
30
0
0.000




(0.10 mg)







Acetophenone (98-86-2)
30
21
0.700
0.700
*


(0.10 mg) + PD23 (0.40 mg)







diethyl ether (60-29-7) (2.0 mg)
21
0
0.000




diethyl ether (60-29-7) (2.0 mg) +
10
1
0.100
0.100
ns


PD23 (0.40 mg)







Isopropyl acetate (108-21-4)
20
3
0.150




(1.0 mg)







Isopropyl acetate (108-21-4)
10
0
0.000
−0.150
ns


(1.0 mg) + PD23 (0.40 mg)







2-butanone (methyl ethyl
36
3
0.083




ketone) (78-93-3) (2.0 mg)







2-butanone (methyl ethyl
34
7
0.206
0.123
ns


ketone) (78-93-3) (2.0 mg) +







PD23 (0.40 mg)







Triacetin (102-76-1) (2.0 mg)
30
1
0.033




Triacetin (102-76-1) (2.0 mg) +
31
22
0.710
0.676
**


PD23 (0.40 mg)







Pyridine (110-86-1) (0.10 mg)
31
1
0.032




Pyridine (110-86-1) (0.10 mg) +
30
30
1.000
0.968
**


PD23 (0.40 mg)







Chloroform-anhydrous (67-
20
1
0.050




66-3) (2.0 mg)







Chloroform-anhydrous (67-
10
0
0.000
−0.050
ns


66-3) (2.0 mg) + PD23 (0.40 mg)







Methyl isobutyl ketone
21
1
0.048




(108-10-1) (1.0 mg)







Methyl isobutyl ketone
10
1
0.100
0.052
ns


(108-10-1) (1.0 mg) + PD23







(0.40 mg)







Tetrahydrofuran (109-99-9)
10
3
0.300




(0.80 mg)







Tetrahydrofuran (109-99-9)
10
0
0.000
−0.300
ns


(0.80 mg) + PD 23 (0.40 mg)







2-ethoxyethanol (ethyl
30
1
0.033




cellosolve) (110-80-5) (0.60 mg)







2-ethoxyethanol (ethyl
31
20
0.645
0.612
**


cellosolve) (110-80-5) (0.60 mg) +







PD23 (0.40 mg)







n-methyl pyrrolidone (872-
10
1
0.100




50-4) (0.05 mg)







n-methyl pyrrolidone (872-
12
1
0.083
−0.017
ns


50-4) (0.05 mg) + PD23







(0.40 mg)







n-methyl pyrrolidone (872-
10
5
0.500




50-4) (0.10 mg)







n-methyl pyrrolidone (872-
10
7
0.700
0.200
ns


50-4) (0.10 mg) + PD23







(0.40 mg)







Polyethylene glycol 200
32
5
0.156




Sigma (25322-68-3) (0.80 mg)







Polyethylene glycol 200
10
3
0.300
0.144
ns


Sigma (25322-68-3) (0.80 mg) +







PD23 (0.40 mg)







Dimethoxymethane
22
0
0.000




(methylal) (109-87-5) (2.0 mg)







Dimethoxymethane
10
1
0.100
0.100
ns


(methylal) (109-87-5) (2.0 mg) +







PD23 (0.40 mg)







Methyl chloroform (71-55-
21
2
0.095




6) (2.00 mg)







Methyl chloroform (71-55-
10
0
0.000
−0.095
ns


6) (2.00 mg) + PD23 (0.40 mg)







Diisopropyl biphenyl Nu-
10
0
0.000




solv (69009-90-1) (0.80 mg)







Diisopropyl biphenyl Nu-
10
2
0.200
0.200



solv (69009-90-1) (0.80 mg) +







PD23 (0.40 mg)







Hexanes (110-54-3) (0.80 mg)
10
1
0.100




Hexanes (110-54-3) (0.80 mg) +
10
0
0.000
−0.100
ns


PD23 (0.40 mg)







Methyl t-butyl ether (1634-
22
5
0.227




04-4) (2.00 mg)







Methyl t-butyl ether (1634-
10
2
0.200
−0.027
ns


04-4) (2.00 mg) + PD23







(0.40 mg)







Dichloromethane
10
0
0.000




(methylene chloride) (75-







09-02) (1.50 mg)







Dichloromethane
10
0
0.000
0.000
ns


(methylene chloride) (75-







09-02) (1.50 mg) + PD23







(0.40 mg)







Toluene (108-88-3) (0.90 mg)
10
0
0.000




Toluene (108-88-3) (0.90 mg) +
10
1
0.100
0.100
ns


PD23 (0.40 mg)









Example 17
1-propanol and 1-heptanol were tested alone and in combination with Exxsol D95 mineral oil. EXXSOL D95 was also tested alone. The results are shown in Table 18. Both alcohols exhibited significant synergy with EXXSOL D95.
When introducing elements of the present disclosure or the preferred embodiments(s) thereof, the articles “a”, “an”, “the” and “said” are intended to mean that there are one or more of the elements. The terms “comprising”, “including” and “having” are intended to be inclusive and mean that there may be additional elements other than the listed elements.
In view of the above, it will be seen that the several objects of the disclosure are achieved and other advantageous results attained.
As various changes could be made in the above compositions and products without departing from the scope of the disclosure, it is intended that all matter contained in the above description shall be interpreted as illustrative and not in a limiting sense.












TABLE 18





Individual or
Total # of


Difference
Significance


combination
cockroaches
# dead at
Proportion
(combination-
(* p < 0.05; **


treatment
treated
24 h
dead at 24 h
solvent)
p < 0.01)




















EXXSOL D95 (64742-
30
1
0.033




47-8) (0.40 mg)







1-heptanol (111-70-
36
1
0.028




6) (0.40 mg)







1-propanol (71-23-
36
1
0.028




8) (0.45 mg)







EXXSOL D95 (0.40 mg) +
21
21
1.000
0.972
**


1 heptanol







(0.40 mg)







EXXSOL D95 (0.40 mg) +
21
19
0.905
0.877
**


1-propanol







(0.40 mg)

## Claims

1. A pesticidal composition comprising at least about 10% mineral oil by weight of the composition and at least about 10% ethyl lactate by weight of the composition.

2. The composition of claim 1 wherein the composition comprises at least about 30% mineral oil by weight of the composition.

3. The composition of claim 1 wherein the composition further comprises a plant essential oil or derivative thereof.

4. The composition of claim 3 wherein the plant essential oil or derivative thereof is geraniol.

5. The composition of claim 4 wherein the composition further comprises isopropyl myristate.

6. The composition of claim 5 wherein the composition comprises, by weight of the composition, about 43% mineral oil, about 15% ethyl lactate, about 30% by weight isopropyl myristate, and about 6% geraniol.

7. The composition of claim 6 wherein the composition further comprises about 3% nerol and about 1% lemongrass oil.

8. The composition of claim 1 wherein the mineral oil is a petroleum distillate.

9. The composition of claim 1 wherein the composition further comprises an emulsifier.

10. The composition of claim 1 wherein the composition comprises from about 10% to about 60% ethyl lactate by weight of the composition.