Exhibit 4.5


 


PROMISSORY
NOTE


 


	$100,000.00	November 9, 2017


 


FOR
VALUE RECEIVED, the undersigned, DERMAdoctor, LLC, a Missouri corporation (“Maker”), hereby promises to
pay to the order of Papillon Partners, Inc., a Missouri corporation or its successors or assigns (“Holder”),
the principal aggregate sum of $100,000.00 plus interest on the unpaid balance at the rate of 6% per annum accruing from the date
hereof. The interest hall be due and payable on the ninth (9th) day of each calendar month beginning on December 9,
2017 with all outstanding principal and accrued and unpaid interest due and payable on the date that is ninety (90) days from
the date hereof. Maker reserves the right to prepay all or any portion of this Promissory Note at any time and from time to time
without premium or penalty of any kind.


 


Notwithstanding
any provision to this Promissory Note to the contrary, if (i) there should be any default in the payment due hereunder. (ii) Maker
should make an assignment for the benefit of creditors, (iii) a receiver, trustee or liquidator is appointed over any property
of Maker, or (iv) proceedings are instituted by or against Maker under any bankruptcy in solvency, reorganization or other law
relating to the relief of debtors, including without limitation the United States Bankruptcy Code, as amended (the events specified
in clauses (i)-(iv) inclusive are hereinafter referred to as an “Event of Default”), then, and in each such
event, Holder may, at its option, and in addition to all other remedies available at law or in equity, without notice or demand,
declare the remaining unpaid principal balance of this Promissory Note immediately due and payable in full.


 


Each
person liable hereon agrees to pay all reasonable costs of collection paid or incurred by Holder in enforcing this Promissory
Note on default or the rights and remedies herein provided, including reasonable attorneys' fee. Maker, for itself and for any
guarantors, sureties, endorsers and/or any other person or persons now or hereafter liable hereon, if any, hereby waives demand
of payment, presentment for payment, protest, notice of nonpayment or dishonor and any and all other notice s and demands whatsoever,
and any and all delays or lack of diligence in the collection hereof, and expressly consents and agrees to any and all extensions
or postponements of the time of payment hereof from time to time at or after maturity and any other indulgence and waives all
notice thereof.


 


No
delay or failure by Holder in exercising any right, power, privilege or remedy hereunder shall affect such right, power, privilege
or remedy or be deemed to be a waiver of the same or any part thereof, nor shall any single or partial exercise thereof or any
failure to exercise the same in any instance preclude any further or future exercise thereof, or exercise of any other right,
power, privilege or remedy. The delay or failure to exercise any right hereunder shall not waive such right.


 


Th.is
Promissory Note shall be governed by and construed and enforced in accordance with the laws of the State of Missouri.


 


IN
WITNESS WHEREOF, Maker has duly caused this Promissory Note to be executed and delivered as of the date first written above.


 


	 	MAKER:
	 	 
	 	DERMAdoctor, LLC
	 	 
	 	By:	/s/
Jeff Kunin
	 	Name:	Jeff Kunin
	 	Title:	Vice President