EX-10.2



 Exhibit 10.2 

THIS WARRANT AND THE UNDERLYING SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
“ACT”), OR UNDER THE SECURITIES LAWS OF ANY STATE. THESE SECURITIES MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED EXCEPT AS PERMITTED UNDER THE ACT AND APPLICABLE STATE SECURITIES LAWS IN
ACCORDANCE WITH APPLICABLE REGISTRATION REQUIREMENTS OR AN EXEMPTION THEREFROM. THE ISSUER OF THESE SECURITIES MAY REQUIRE AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE ISSUER THAT SUCH OFFER, SALE, TRANSFER, PLEDGE OR HYPOTHECATION OTHERWISE
COMPLIES WITH THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS. THIS WARRANT MUST BE SURRENDERED TO THE COMPANY OR ITS TRANSFER AGENT AS A CONDITION PRECEDENT TO THE SALE, TRANSFER, PLEDGE OR HYPOTHECATION OF ANY INTEREST IN ANY OF THE SECURITIES
REPRESENTED HEREBY. 
 WARRANT TO PURCHASE SHARES OF COMMON STOCK 

OF 
 OMEROS CORPORATION

 Dated as of April 12, 2018 

Void after the date specified in Section 8 

    Warrant to Purchase 

2,000 Shares of 
 Common
Stock 
 (subject to adjustment) 

THIS CERTIFIES THAT, for value received, CRG PARTNERS III – PARALLEL FUND “A” L.P., or its registered assigns (the
“Holder”), is entitled, subject to the provisions and upon the terms and conditions set forth herein, to purchase from Omeros Corporation, a Washington corporation (the “Company”), shares of the
Company’s common stock, par value $0.01 per share (such shares, the “Shares” and such common stock, the “Common Stock”), in the amounts, at such times and at the price per share set forth in
Section 1. The term “Warrant” as used herein shall include this Warrant and any warrants delivered in substitution or exchange therefor as provided herein. This Warrant is issued in connection with the transactions
described in Amendment No. 3 to Loan Agreement, dated as of April 10, 2018, by and among the Company, CRG Servicing LLC, as administrative and collateral agent, and the lenders party thereto, which amends that certain Term Loan Agreement,
dated as of October 26, 2016 (as so amended and as further amended, modified or supplemented from time to time, the “Loan Agreement”), by and among the Company, the Subsidiary Guarantors from time to time party thereto,
the Lenders from time to time party thereto and CRG Servicing LLC. 
 The following is a statement of the rights of the Holder and the
conditions to which this Warrant is subject, and to which Holder, by acceptance of this Warrant, agrees: 
 1. Number and Price of
Shares; Exercise Period. 
 (a) Number of Shares. Subject to any previous exercise of the Warrant, the Holder shall have
the right to purchase up to 2,000 Shares, as may be adjusted pursuant hereto prior to (or in connection with) the expiration of this Warrant as provided in Section 8. 

(b) Exercise Price. The exercise price per Share shall be equal to $23.00, subject to adjustment pursuant hereto (the
“Exercise Price”). 
 (c) Exercise Period. This Warrant shall be exercisable, in whole or in part,
prior to (or in connection with) the expiration of this Warrant as set forth in Section 8. 
 2. Exercise of the Warrant. 

(a) Exercise. The purchase rights represented by this Warrant may be exercised at the election of the Holder, in whole or in
part, in accordance with Section 1, by: 







 (i) the tender to the Company at its principal office (or such other office or agency as the
Company may designate) of a notice of exercise in the form of Exhibit A (the “Notice of Exercise”), duly completed and executed by or on behalf of the Holder, together with the surrender of this Warrant; and 

(ii) the payment to the Company of an amount equal to (x) the Exercise Price multiplied by (y) the number of Shares being
purchased, by wire transfer or certified, cashier’s or other check acceptable to the Company and payable to the order of the Company. 

(b) Net Issue Exercise. In lieu of exercising this Warrant pursuant to Section 2(a)(ii), if the fair market value of one
Share is greater than the Exercise Price (at the date of calculation as set forth below), the Holder may elect to receive a number of Shares equal to the value of this Warrant (or of any portion of this Warrant being canceled) by surrender of this
Warrant at the principal office of the Company (or such other office or agency as the Company may designate) together with a properly completed and executed Notice of Exercise reflecting such election, in which event the Company shall issue to the
Holder that number of Shares computed using the following formula: 
  

									
		 	X	  	=	  	Y (A – B)    	 	
	 	  	  	        A	 	

 Where: 
  

					
	            X	  	=	  	The number of Shares to be issued to the Holder
			
	            Y	  	=	  	The number of Shares purchasable under this Warrant or, if only a portion of the Warrant is being exercised, the portion of the Warrant being canceled (at the date of such calculation)
			
	            A	  	=	  	The fair market value of one Share (at the date of such calculation)
			
	            B	  	=	  	The Exercise Price (as adjusted to the date of such calculation)

 For purposes of the calculation above, the fair market value of one Share shall be determined as follows: 

(i)    if the Shares are traded on any securities exchange or quoted on an established automated over-the-counter market, the fair market value shall be deemed to be the average of the closing prices over a ten (10) Trading Day period ending five (5) Trading
Days before the date of calculation; or 
 (ii)    if at any time the Common Stock is not listed on any
securities exchange or quoted on an established automated over-the-counter market, the fair market value of the Common Stock shall be the price per share which the
Company could obtain from a willing buyer (not a current employee or director) for shares of Common Stock sold by the Company, from authorized but unissued shares, as determined in good faith by its Board of Directors, unless the Company shall
become subject to a Reorganization, in which case the fair market value of the Common Stock shall be deemed to be the per share value received by the holders of the Common Stock pursuant to such Reorganization. 

For purposes hereof, the date of calculation shall be the date the Holder sends to the Company a Notice of Exercise. “Trading
Day” means a day in which trading in the Shares generally occurs on The Nasdaq Global Market or if the Shares are not then listed on The Nasdaq Global Market, on the principal other U.S. national or regional securities exchange on which
the Shares are then listed, or if the Shares are not then listed on a U.S. national or regional securities exchange, on the principal other market on which the Shares are then traded. If the Shares are not so listed or traded, “Trading
Day” means any Business Day. “Business Day” means any day other than a Saturday, a Sunday or a day on which the Federal Reserve Bank of New York is authorized or required by law or executive order to close or be closed.


  
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 (c) Exercise Prior to Expiration. To the extent this Warrant is not previously
exercised as to all Shares subject hereto, and if the fair market value of one Share is greater than the Exercise Price then in effect, this Warrant shall be deemed automatically exercised pursuant to Section 2(b) (even if not surrendered)
immediately before its expiration. For purposes of such automatic exercise, the fair market value of one Share upon such expiration shall be determined pursuant to Section 2(b). To the extent this Warrant or any portion thereof is deemed
automatically exercised pursuant to this Section 2(c), the Company agrees to promptly notify the Holder of the number of shares of Common Stock, if any, the Holder is to receive by reason of such automatic exercise. 

(d) Stock Certificates. The rights under this Warrant shall be deemed to have been exercised and the Shares issuable upon such
exercise shall be deemed to have been issued immediately prior to the close of business on the date this Warrant is exercised in accordance with its terms, and the person entitled to receive the Shares issuable upon such exercise shall be treated
for all purposes as the holder of record of such Shares as of the close of business on such date. As promptly as reasonably practicable on or after such date, the Company shall issue and deliver to the person or persons entitled to receive the same
a certificate or certificates for that number of shares issuable upon such exercise. In the event that the rights under this Warrant are exercised in part and have not expired, the Company shall execute and deliver a new Warrant reflecting the
number of Shares that remain subject to this Warrant. 
 (e) No Fractional Shares or Scrip. No fractional shares or scrip
representing fractional shares shall be issued upon the exercise of the rights under this Warrant. In lieu of such fractional share to which the Holder would otherwise be entitled, the Company shall make a cash payment equal to the Exercise Price multiplied by such fraction. 
 (f) Conditional Exercise. The Holder may
exercise this Warrant conditioned upon (and effective immediately prior to) consummation of any transaction that would cause the expiration of this Warrant pursuant to Section 8 by so indicating in the notice of exercise. 

(g) Reservation of Stock. The Company agrees during the term the rights under this Warrant are exercisable to reserve and keep
available from its authorized and unissued shares of Common Stock for the purpose of effecting the exercise of this Warrant such number of shares as shall from time to time be sufficient to effect the exercise of the rights under this Warrant; and
if at any time the number of authorized but unissued shares of Common Stock shall not be sufficient for purposes of the exercise of this Warrant in accordance with its terms, without limitation of such other remedies as may be available to the
Holder, the Company will use all reasonable efforts to take such corporate action as may be necessary to increase its authorized and unissued shares of Common Stock to a number of shares as shall be sufficient for such purposes. The Company
represents and warrants that all shares that may be issued upon the exercise of this Warrant will, when issued in accordance with the terms hereof, be validly issued, fully paid and nonassessable. 

3. Replacement of the Warrant. Subject to the receipt of evidence reasonably satisfactory to the Company of the loss, theft,
destruction or mutilation of this Warrant and, in the case of loss, theft or destruction, on delivery of an indemnity agreement reasonably satisfactory in form and substance to the Company or, in the case of mutilation, on surrender and cancellation
of this Warrant, the Company at the expense of the Holder shall execute and deliver, in lieu of this Warrant, a new warrant of like tenor and amount. 

4. Transfer of the Warrant. 

(a) Warrant Register. The Company shall maintain a register (the “Warrant Register”) containing the name
and address of the Holder or Holders. Until this Warrant is transferred on the Warrant Register in accordance herewith, the Company may treat the Holder as shown on the Warrant Register as the absolute owner of this Warrant for all purposes,
notwithstanding any notice to the contrary. Any Holder of this Warrant (or of any portion of this Warrant) may change its address as shown on the Warrant Register by written notice to the Company requesting a change. 

(b) Warrant Agent. The Company may appoint an agent for the purpose of maintaining the Warrant Register referred to in
Section 4(a), issuing the Shares or other securities then issuable upon the exercise of the rights under this Warrant, exchanging this Warrant, replacing this Warrant or conducting related activities. 

  
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 (c) Transferability of the Warrant. Subject to (i) the provisions of this
Warrant with respect to compliance with the Securities Act of 1933, as amended (the “Securities Act”), as set forth in Section 5 and (ii) compliance with the lock-up
requirements as set forth in Section 11(b), title to this Warrant may be transferred by endorsement (by the transferor and the transferee executing the assignment form attached as Exhibit B (the “Assignment
Form”)) and delivery in the same manner as a negotiable instrument transferable by endorsement and delivery ; provided that the Holder shall not transfer title to this Warrant to any person that is not an Eligible Transferee (as defined
in the Loan Agreement), without the prior written consent of the Company. 
 (d) Exchange of the Warrant upon a Transfer. On
surrender of this Warrant (and a properly endorsed Assignment Form) for exchange, subject to the provisions of this Warrant with respect to compliance with the Securities Act and limitations on assignments and transfers, the Company shall issue to
or on the order of the Holder a new warrant or warrants of like tenor, in the name of the Holder or as the Holder (on payment by the Holder of any applicable transfer taxes) may direct, for
the number of shares issuable upon exercise hereof, and the Company shall register any such transfer upon the Warrant Register. This Warrant (and the securities issuable upon exercise of the rights under this Warrant) must be surrendered to the
Company or its warrant or transfer agent, as applicable, as a condition precedent to the sale, pledge, hypothecation or other transfer of any interest in any of the securities represented hereby. 

(e) Taxes. In no event shall the Company be required to pay any tax which may be payable in respect of any transfer involved in
the issue and delivery of any certificate in a name other than that of the Holder, and the Company shall not be required to issue or deliver any such certificate unless and until the person or persons requesting the issue thereof shall have paid to
the Company the amount of such tax or shall have established to the satisfaction of the Company that such tax has been paid or is not payable. 

5. Compliance with Securities Laws. By acceptance of this Warrant, the Holder agrees to comply with the following: 
 (a)
Restrictions on Transfers. Any transfer of this Warrant or the Shares (the “Securities”) must be in compliance with all applicable federal and state securities laws. The Holder agrees not to make any sale,
assignment, transfer, pledge or other disposition of all or any portion of the Securities, or any beneficial interest therein, unless and until the transferee thereof has agreed in writing for the benefit of the Company to take and hold such
Securities subject to, and to be bound by, the terms and conditions set forth in this Warrant to the same extent as if the transferee were the original Holder hereunder, and 

(i) there is then in effect a registration statement under the Securities Act covering such proposed disposition and such disposition is made
in accordance with such registration statement, or 
 (ii) (A) such Holder shall have given prior written notice to the Company of
such Holder’s intention to make such disposition and shall have furnished the Company with a reasonable detailed description of the manner and circumstances of the proposed disposition, (B) the transferee shall have made the
representations set forth in Section 10 with respect to itself as a Holder and (C) if requested by the Company, such Holder shall have furnished the Company, at the Holder’s expense, with (i) evidence reasonably satisfactory to
the Company that such disposition will not require registration of such Securities under the Securities Act or (ii) a legal opinion to the effect that the transfer of such Securities may be effected in compliance with the terms of the
Securities Act. Notwithstanding the foregoing, compliance with clauses (B) and (C) above shall not be required for any transfer in compliance with Rule 144 and compliance with clause (C) above shall not be required for any transfer by the
Holder to any affiliate of the Holder (or any fund or partnership under common control with one of more general partners or managing members of, or shares the same management company with, the Holder) or a transfer by the Holder to any of the
Holder’s partners, members or other equity owners, or retired partners, members or other equity owners or the estate of any partners, members or other equity owners or retired partners, members or other equity owners.

(b) Investment Representation Statement. Unless the rights under this Warrant are exercised pursuant to an effective
registration statement under the Securities Act that includes the Shares with respect to which the Warrant was exercised or pursuant to Section 2(b) that results in the Shares issued upon exercise being eligible for resale under Rule 144, it
shall be a condition to any exercise of the rights under this Warrant that the Holder shall have confirmed the representations set forth in Section 10 hereof. 

  
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 (c) Securities Law Legend. Subject to Section 5(e), the Securities shall
(unless otherwise permitted by the provisions of this Warrant) be stamped or imprinted with a legend substantially similar to the following (in addition to any legend required by state securities laws): 

THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR UNDER THE
SECURITIES LAWS OF CERTAIN STATES. THESE SECURITIES MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED EXCEPT AS PERMITTED UNDER THE ACT AND APPLICABLE STATE SECURITIES LAWS IN ACCORDANCE WITH APPLICABLE REGISTRATION
REQUIREMENTS OR AN EXEMPTION THEREFROM. THE ISSUER OF THESE SECURITIES MAY REQUIRE AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE ISSUER THAT SUCH OFFER, SALE OR TRANSFER, PLEDGE OR HYPOTHECATION OTHERWISE COMPLIES WITH THE ACT AND ANY
APPLICABLE STATE SECURITIES LAWS. THIS CERTIFICATE MUST BE SURRENDERED TO THE COMPANY OR ITS TRANSFER AGENT AS A CONDITION PRECEDENT TO THE SALE, TRANSFER, PLEDGE OR HYPOTHECATION OF ANY INTEREST IN ANY OF THE SECURITIES REPRESENTED HEREBY. 

(d) Instructions Regarding Transfer Restrictions. Subject to Section 5(e), the Holder consents to the Company making a
notation on its records and giving instructions to any transfer agent in order to implement the restrictions on transfer established in this Section 5. 

(e) Removal of Legend. The legend referring to federal and state securities laws identified in Section 5(c) stamped on a
certificate evidencing the Shares and the stock transfer instructions and record notations with respect to such securities shall be removed promptly upon request by the Holder and the Company shall issue a certificate without such legend to the
holder of such securities if (i) such securities are registered under the Securities Act, (ii) such securities are to be resold under Rule 144, or (iii) such holder provides the Company with an opinion of counsel reasonably acceptable
to the Company to the effect that a sale or transfer of such securities may be made without registration or qualification. 
 (f)
Compliance with Securities Laws. The Holder is aware of the restrictions imposed by the United States securities laws on the purchase or sale of securities by any person who has received material,
non-public information from the issuer of such securities and on the communication of such information to any other person when it is reasonably foreseeable that such other person is likely to purchase or sell
such securities in reliance upon such information. 
 6. Adjustments. Subject to the expiration of this Warrant pursuant to
Section 8, the number and kind of shares purchasable hereunder and the Exercise Price therefor are subject to adjustment from time to time, as follows: 

(a) Merger or Reorganization. If at any time there shall be any reorganization, recapitalization, merger or consolidation (a
“Reorganization”) involving the Company (other than as otherwise provided for herein or as would cause the expiration of this Warrant under Section 8) in which shares of the Company’s stock are converted into or
exchanged for securities, cash or other property, then, as a part of such Reorganization, lawful provision shall be made so that the Holder shall thereafter be entitled to receive upon exercise of this Warrant, the kind and amount of securities,
cash or other property of the successor corporation resulting from such Reorganization (collectively, “Reference Property”), equivalent in value to that which a holder of the Shares deliverable upon exercise of this Warrant
would have been entitled in such Reorganization if the right to purchase the Shares hereunder had been exercised immediately prior to such Reorganization. In any such case, appropriate adjustment (as determined in good faith by the Board of
Directors of the successor corporation) shall be made in the application of the provisions of this Warrant with respect to the rights and interests of the Holder after such Reorganization to the end that the provisions of this Warrant shall be
applicable after the event, as near as reasonably may be, in relation to any shares or other securities deliverable after that event upon the exercise of this Warrant. Without limiting the foregoing, in connection with any Reorganization, upon the
closing thereof, the successor or surviving entity shall assume the obligations of this Agreement. The provisions of this Section 6(a) shall similarly apply to successive Reorganizations. 

  
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 (b) Reclassification of Shares. If the securities issuable upon exercise of this
Warrant are changed into the same or a different number of securities of any other class or classes by reclassification, capital reorganization or otherwise (other than as otherwise provided for herein) (a
“Reclassification”), then, in any such event, in lieu of the number of Shares which the Holder would otherwise have been entitled to receive, the Holder shall have the right thereafter to exercise this Warrant for a number of
shares of such other class or classes of stock that a holder of the number of securities deliverable upon exercise of this Warrant immediately before that change would have been entitled to receive in such Reclassification, all subject to further
adjustment as provided herein with respect to such other shares. 
 (c) Subdivisions and Combinations. In the event that the
outstanding shares of Common Stock are subdivided (by stock split, by payment of a stock dividend or otherwise) into a greater number of shares of such securities, the number of Shares issuable upon exercise of the rights under this Warrant
immediately prior to such subdivision shall, concurrently with the effectiveness of such subdivision, be proportionately increased, and the Exercise Price shall be proportionately decreased, and in the event that the outstanding shares of Common
Stock are combined (by reclassification or otherwise) into a lesser number of shares of such securities, the number of Shares issuable upon exercise of the rights under this Warrant immediately prior to such combination shall, concurrently with the
effectiveness of such combination, be proportionately decreased, and the Exercise Price shall be proportionately increased. 
 (d)
Notice of Adjustments. Upon any adjustment in accordance with this Section 6, the Company shall give notice thereof to the Holder, which notice shall state the event giving rise to the adjustment, the Exercise Price as adjusted
and the number of securities or other property purchasable upon the exercise of the rights under this Warrant, setting forth in reasonable detail the method of calculation of each. The Company shall, upon the written request of any Holder, furnish
or cause to be furnished to such Holder a certificate setting forth (i) such adjustments, (ii) the Exercise Price at the time in effect and (iii) the number of securities and the amount, if any, of other property that at the time
would be received upon exercise of this Warrant. 
 7. Notification of Certain Events. Prior to the expiration of this Warrant pursuant to Section 8, in the event that the Company shall authorize: 

(a) the issuance of any dividend or other distribution on the capital stock of the Company (other than (i) dividends or distributions
otherwise provided for in Section 6, (ii) repurchases of Common Stock issued to or held by employees, officers, directors or consultants of the Company or its subsidiaries upon termination of their employment or services pursuant to agreements
providing for the right of said repurchase (excluding any deemed repurchase pursuant to a net exercise of Company equity securities); (iii) repurchases of Common Stock issued to or held by employees, officers, directors or consultants of the Company
or its subsidiaries pursuant to rights of first refusal or first offer contained in agreements providing for such rights; or (iv) repurchases of capital stock of the Company in connection with the settlement of disputes with any stockholder ),
whether in cash, property, stock or other securities; 
 (b) the voluntary liquidation, dissolution or winding up of the Company; or 

(c) any transaction resulting in the expiration of this Warrant pursuant to Section 8(b); 

the Company shall send to the Holder of this Warrant at least ten (10) calendar days prior written notice of the date on which a record shall be taken
for any such dividend or distribution specified in clause (a) or the expected effective date of any such other event specified in clause (b) or (c), as applicable. The notice provisions set forth in this section may be shortened or waived
prospectively or retrospectively by the consent of the Holder of this Warrant. 
 8. Expiration of the Warrant. This Warrant
shall expire and shall no longer be exercisable as of the earlier of: 
 (a) 5:00 p.m., Pacific time, on April 12, 2023; or 

  
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 (b) (i) the acquisition of the Company by another entity by means of any transaction or
series of related transactions to which the Company is a party (including, without limitation, any stock acquisition, reorganization, merger or consolidation, but excluding any sale of stock for capital raising purposes and any transaction effected
primarily for purposes of changing the Company’s jurisdiction of incorporation) other than a transaction or series of related transactions in which the holders of the voting securities of the Company outstanding immediately prior to such
transaction or series of related transactions receive voting securities of such other surviving or resulting entity (or if the Company or such other surviving or resulting entity is a wholly owned subsidiary immediately following such acquisition,
its parent), or (ii) a sale, lease or other disposition of all or substantially all of the assets of the Company and its subsidiaries taken as a whole by means of any transaction or series of related transactions, except where such sale, lease
or other disposition is to a wholly owned subsidiary of the Company. 
 9. No Rights as a Stockholder. Nothing contained
herein shall entitle the Holder to any rights as a stockholder of the Company or to be deemed the holder of any securities that may at any time be issuable on the exercise of the rights hereunder for any purpose nor shall anything contained herein
be construed to confer upon the Holder, as such, any right to vote for the election of directors or upon any matter submitted to stockholders at any meeting thereof, or to give or withhold consent to any corporate action (whether upon any
recapitalization, issuance of stock, reclassification of stock, change of par value or change of stock to no par value, consolidation, merger, conveyance or otherwise) or to receive notice of meetings, or to receive dividends or subscription rights
or any other rights of a stockholder of the Company until the rights under the Warrant shall have been exercised and the Shares purchasable upon exercise of the rights hereunder shall have become deliverable as provided herein. 

10. Representations and Warranties of the Holder. By acceptance of this Warrant, the Holder represents and warrants to the
Company as follows: 
 (a) No Registration. The Holder understands that the Securities have not been, and will not be,
registered under the Securities Act by reason of a specific exemption from the registration provisions of the Securities Act, the availability of which depends upon, among other things, the bona fide nature of the investment intent and the
accuracy of the Holder’s representations as expressed herein or otherwise made pursuant hereto. 
 (b) Investment Intent.
The Holder is acquiring the Securities for investment for its own account, not as a nominee or agent, and not with a view to, or for resale in connection with, any distribution thereof. The Holder has no present intention of selling, granting any
participation in, or otherwise distributing the Securities, nor does it have any contract, undertaking, agreement or arrangement for the same. 

(c) Investment Experience. The Holder has substantial experience in evaluating and investing in private placement transactions
of securities in companies similar to the Company, and has such knowledge and experience in financial or business matters so that it is capable of evaluating the merits and risks of its investment in the Company and protecting its own interests.

 (d) Speculative Nature of Investment. The Holder understands and acknowledges that its investment in the Company is highly
speculative and involves substantial risks. The Holder can bear the economic risk of its investment and is able, without impairing its financial condition, to hold the Securities for an indefinite period of time and to suffer a complete loss of its
investment. 
 (e) Accredited Investor. The Holder is an “accredited investor” within the meaning of Regulation D,
Rule 501(a), promulgated by the Securities and Exchange Commission and agrees to submit to the Company such further assurances of such status as may be reasonably requested by the Company. The Holder has furnished or made available any and all
information requested by the Company or otherwise necessary to satisfy any applicable verification requirements as to “accredited investor” status. Any such information is true, correct, timely and complete. 

(f) Residency. The residency of the Holder (or, in the case of a partnership or corporation, such entity’s principal place
of business) is correctly set forth on the signature page hereto. 
 (g) Restrictions on Resales. The Holder acknowledges that
the Securities must be held indefinitely 

  
 7 








 
unless subsequently registered under the Securities Act or an exemption from such registration is available. The Holder is aware of the provisions of Rule 144 promulgated under the Securities
Act, which permit resale of shares purchased in a private placement subject to the satisfaction of certain conditions, which may include, among other things, the availability of certain current public information about the Company; the resale
occurring not less than a specified period after a party has purchased and paid for the security to be sold; the number of shares being sold during any three-month period not exceeding specified limitations; the sale being effected through a
“broker’s transaction,” a transaction directly with a “market maker” or a “riskless principal transaction” (as those terms are defined in the Securities Act or the Securities Exchange Act of 1934, as amended (the
“Exchange Act”), and the rules and regulations promulgated thereunder); and the filing of a Form 144 notice, if applicable. The Holder acknowledges and understands that the Company may not be satisfying the current public
information requirement of Rule 144 at the time the Holder wishes to sell the Securities and that, in such event, the Holder may be precluded from selling the Securities under Rule 144 even if the other applicable requirements of Rule 144 have been
satisfied. The Holder acknowledges that, in the event the applicable requirements of Rule 144 are not met, registration under the Securities Act or an exemption from registration will be required for any disposition of the Securities. The Holder
understands that, although Rule 144 is not exclusive, the Securities and Exchange Commission has expressed its opinion that persons proposing to sell restricted securities received in a private offering other than in a registered offering or
pursuant to Rule 144 will have a substantial burden of proof in establishing that an exemption from registration is available for such offers or sales and that such persons and the brokers who participate in the transactions do so at their own risk.

 (h) Authorization. The Holder has full legal capacity, power and authority to execute and deliver this Warrant and to
perform its obligations hereunder. This Warrant constitutes the valid and binding obligations of the Holder, enforceable in accordance with its terms, except as limited by bankruptcy, insolvency or other laws of general application relating to or
affecting the enforcement of creditors’ rights generally and general principles of equity. 
 11. Covenants of the
Holder. Except as specified in the second sentence of clause (b), the following covenants shall apply only to the Shares and shall not limit in any way the Holder’s ability to transfer the Warrant in accordance with Section 4(c) and
Section 5(a) hereof. 
 (a) Compliance with Insider Trading Policy. Until the later of (i) the date on which the
Commitments (as defined in the Loan Agreement) pursuant to the Loan Agreement have expired or been terminated and all Obligations (as defined in the Loan Agreement) (other than inchoate indemnity obligations) under the Loan Agreement have been paid
in full indefeasibly in cash (such date, the “Loan Payoff Date”) and (ii) the date on which the Holder shall not have any material non-public information concerning the Company,
the Holder shall not sell, offer, pledge, sell, contract to sell, sell any option to purchase, purchase any option or contract to sell, grant any option, right or warrant to purchase or otherwise transfer or dispose of, directly or indirectly, the
Warrant or any Shares unless the same would then be permitted under terms and conditions of its insider trading policy 
 (b) Lock-Up. The Holder will not, during the period ending on the earlier of (x) the first anniversary date of the issuance of any Shares due to the exercise of the Warrant (or, with respect to the exercise
of any portion of the Warrant, the first anniversary date of the issuance of any Shares due to the exercise of the final portion of the Warrant) and (y) the Loan Payoff Date, offer, pledge, sell, contract to sell, sell any option or contract to
purchase, purchase any option or contract to sell, grant any option, right or warrant to purchase, lend or otherwise transfer or dispose of, directly or indirectly, the applicable Shares. Furthermore, the Holder will not, during the period ending on
the earlier of (x) April 12, 2019 and (y) the Loan Payoff Date, offer, pledge, sell, contract to sell, sell any option or contract to purchase, purchase any option or contract to sell, grant any option, right or warrant to purchase,
or otherwise transfer or dispose of, directly or indirectly, the Warrant. 
 (c) Exceptions. The foregoing clauses
(a) and (b) shall not apply to: (i) transfers of Shares as a bona fide gift or charitable contribution in a transaction not involving distribution for value; (ii) distributions of Shares to limited partners, members, stockholders or
holders of similar equity interests in the undersigned in a transaction not involving distribution for value; (iii) transfers or distributions of Shares to any affiliate or fund under common control; (iv) transfers of Shares to an
immediate family member or a trust for the direct or indirect benefit of the undersigned or such immediate family member of the undersigned in a transaction not involving distribution for value (for purposes of this Section 11(b),
“immediate family” shall mean any relationship by blood, marriage or adoption, not more remote 

  
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than first cousin); (v) transfers of Shares and/or the Warrant by will or intestacy or pursuant to a domestic relations order, divorce decree or court order, (vi) transfers of Shares and/or
the Warrant by a stockholder that is a trust to a trustor or beneficiary of the trust or to the estate of a beneficiary of such trust in a transaction not involving distribution for value; (vii) bona fide pledges of the Shares and/or the
Warrant to secure indebtedness of the holder or its affiliates; and (viii) transfers of Shares and/or the Warrant pursuant to a Reorganization; provided that, in the case of transfers pursuant to clauses (i) through (vi), the
transferee will remain subject to the lock-up periods specified in the foregoing clause (b). 
 (d)
Prohibition on Short Sales. Prior to the earlier of the expiration of this Warrant and such time as the Holder ceases to be a Holder, the Holder agrees that it will not engage in any short sales (as defined in Rule 200 of Regulation
SHO under the Exchange Act) of the Shares or enter into any stock loan arrangement with regards to the Shares. 
 12. Miscellaneous.

 (a) Amendments. Except as expressly provided herein, neither this Warrant nor any term hereof may be amended, waived,
discharged or terminated other than by a written instrument referencing this Warrant and signed by the Company and the Holder of this Warrant. 

(b) Waivers. No waiver of any single breach or default shall be deemed a waiver of any other breach or default theretofore or
thereafter occurring. 
 (c) Notices. All notices and other communications required or permitted hereunder shall be in writing
and shall be mailed by registered or certified mail, postage prepaid, sent by facsimile or electronic mail (if to the Holder) or otherwise delivered by hand, messenger or courier service addressed: 

(i) if to the Holder, to the Holder at the Holder’s address, facsimile number or electronic mail address as shown in the Company’s
records, as may be updated in accordance with the provisions hereof, or until any such Holder so furnishes an address, facsimile number or electronic mail address to the Company, then to and at the address, facsimile number or electronic mail
address of the last holder of this Warrant for which the Company has contact information in its records; or 
 (ii) if to the Company, to
the attention of the Chief Executive Officer or Chief Financial Officer of the Company at the Company’s address as shown on the signature page hereto, or at such other current address as the Company shall have furnished to the Holder. 

Each such notice or other communication shall for all purposes of this Warrant be treated as effective or having been given (i) if
delivered by hand, messenger or courier service, when delivered (or if sent via a nationally-recognized overnight courier service, freight prepaid, specifying next-business-day delivery, one business day after
deposit with the courier), or (ii) if sent via mail, at the earlier of its receipt or five days after the same has been deposited in a regularly-maintained receptacle for the deposit of the United States mail, addressed and mailed as aforesaid,
or (iii) if sent via facsimile, upon confirmation of facsimile transfer or, if sent via electronic mail, upon confirmation of delivery when directed to the relevant electronic mail address, if sent during normal business hours of the recipient,
or if not sent during normal business hours of the recipient, then on the recipient’s next business day. In the event of any conflict between the Company’s books and records and this Warrant or any notice delivered hereunder, the
Company’s books and records will control absent fraud or error. 
 (d) Governing Law. This Warrant and all actions
arising out of or in connection with this Warrant shall be governed by and construed in accordance with the laws of the State of Washington, without regard to the conflicts of law provisions of the State of Washington, or of any other state. 

(e) Jurisdiction and Venue. The Company agrees that any suit, action or proceeding with respect to this Agreement or
any other Loan Document to which it is a party or any judgment entered by any court in respect thereof may be brought initially in the federal or state courts in Houston, Texas or in the courts of its own corporate domicile and irrevocably submits
to the non-exclusive jurisdiction of each such court for the purpose of any such suit, action, proceeding or judgment. This Section 12(e) is for the benefit of the Holder only and, as a result, Holder
shall 

  
 9 








 
not be prevented from taking proceedings in any other courts with jurisdiction. Nothing herein shall in any way be deemed to limit the ability of the Holder to serve any such process or summonses
in any other manner permitted by applicable law. The Company irrevocably waives to the fullest extent permitted by law any objection that it may now or hereafter have to the laying of the venue of any suit, action or proceeding arising out of or
relating to this Warrant and hereby further irrevocably waives to the fullest extent permitted by law any claim that any such suit, action or proceeding brought in any such court has been brought in an inconvenient forum. A final judgment (in
respect of which time for all appeals has elapsed) in any such suit, action or proceeding shall be conclusive and may be enforced in any court to the jurisdiction of which the Company is or may be subject, by suit upon judgment. 

(f) Titles and Subtitles. The titles and subtitles used in this Warrant are used for convenience only and are not to be
considered in construing or interpreting this Warrant. All references in this Warrant to sections, paragraphs and exhibits shall, unless otherwise provided, refer to sections and paragraphs hereof and exhibits attached hereto. 

(g) Severability. If any provision of this Warrant becomes or is declared by a court of competent jurisdiction to be illegal,
unenforceable or void, portions of such provision, or such provision in its entirety, to the extent necessary, shall be severed from this Warrant, and such illegal, unenforceable or void provision shall be replaced with a valid and enforceable
provision that will achieve, to the extent possible, the same economic, business and other purposes of the illegal, unenforceable or void provision. The balance of this Warrant shall be enforceable in accordance with its terms. 

(h) Waiver of Jury Trial. EACH OF THE HOLDER AND THE COMPANY WAIVES, TO THE FULLEST EXTENT PERMITTED BY LAW, ANY AND ALL
RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING (WHETHER BASED ON CONTRACT, TORT OR OTHERWISE) ARISING OUT OF OR RELATED TO THIS WARRANT. 

(i) Saturdays, Sundays and Holidays. If the last or appointed day for the taking of any action or the expiration of any right
required or granted herein shall be a Saturday, Sunday or U.S. federal holiday, then such action may be taken or such right may be exercised on the next succeeding day that is not a Saturday, Sunday or U.S. federal holiday. 

(j) Rights and Obligations Survive Exercise of the Warrant. Except as otherwise provided herein, the rights and obligations of
the Company and the Holder under this Warrant shall survive exercise of this Warrant. 
 (k) Entire Agreement. Except as
expressly set forth herein, this Warrant (including the exhibits attached hereto) constitutes the entire agreement and understanding of the Company and the Holder with respect to the subject matter hereof and supersede all prior agreements and
understandings relating to the subject matter hereof. 
 (signature page follows) 

  
 10 








 The Company and the Holder sign this Warrant as of the date stated on the first page. 

 

			
	 COMPANY:
  

	OMEROS CORPORATION
		
	By:	 	  

		 	 Name:

		 	Title:


  

			
	Address for Notices:
	201 Elliott Avenue West
	Seattle, Washington 98119
	Attn:	 	Chief Executive Officer
	Tel.:	 	206-676-5000
	Fax:	 	206-676-5005
	Email:	 	gdemopulos@omeros.com
	
	with a copy to:
	
	201 Elliott Avenue West
	Seattle, Washington 98119
	Attn:	 	General Counsel
	Tel.:	 	206-676-5000
	Fax:	 	206-676-5005
	Email:	 	mkelbon@omeros.com


  

	
	 AGREED AND ACKNOWLEDGED:

	
	 HOLDER:
  


  

			
	By:	 	  



			
	Name:
	Title: 

 Address for Notices: 
 1000 Main
Street, Suite 2500 
 Houston, TX 77002 
 Attn: Portfolio
Reporting 
 Tel.: 713.209.7350 
 Fax: 713.209.7351 

Email: notices@crglp.com 
 [Signature Page –
Warrant] 







 EXHIBIT A 

NOTICE OF EXERCISE 
  

			
	TO:	  	OMEROS CORPORATION (the “Company”) 
		
	Attention:	  	CHIEF FINANCIAL OFFICER

  

			
	(1)	 	Exercise. The undersigned elects to purchase the following pursuant to the terms of the attached warrant:

  

			
	        Number of shares:	 	  

		
	        Type of security:	 	  


  

			
	(2)	 	Method of Exercise. The undersigned elects to exercise the attached warrant pursuant to:

  

			
	        [    ]	  	A cash payment, and tenders herewith payment of the purchase price for such shares in full, together with all applicable transfer taxes, if any.
		
	        [    ]	  	The net issue exercise provisions of Section 2(b) of the attached warrant.

  

			
	(3)	 	Conditional Exercise. Is this a conditional exercise pursuant to Section 2(f):

  

			
	        [    ] Yes     [    ] No	  	
		
	        If “Yes,” indicate the applicable condition:	  	
	
	
                   
                                         
                                         
                                         
                                         
            



	
	

  

			
	(4)	 	Stock Certificate. Please issue a certificate or certificates representing the shares in the name of:

  

			
	        [    ]    The undersigned	 	
		
	        [    ]    Other—Name:	 	  

		
	                  Address:	 	  

		
		 	  


  

			
	(5)	 	Unexercised Portion of the Warrant. Please issue a new warrant for the unexercised portion of the attached warrant in the name of:

  

			
	        [    ]    The undersigned	 	
		
	        [    ]    Other—Name:	 	  

		
	                  Address:	 	  

		
		 	  

		
	        [    ]    Not applicable	 	

  

			
	(6)	  	[Investment Intent. The undersigned represents and warrants that the aforesaid shares are being acquired for investment for its own account and not with a view to, or for resale in connection with, the distribution
thereof, and that the undersigned has no present intention of selling, granting any participation in, or otherwise


  
 A-1 









			
		  	distributing the shares, nor does it have any contract, undertaking, agreement or arrangement for the same, and all representations and warranties of the undersigned set forth in Section 10 of the attached warrant are true
and correct as of the date hereof. ]1 
		
	 ([6][7])
	  	Consent to Receipt of Electronic Notice. The undersigned consents to the delivery of any notice to stockholders given by the Company under the Washington Business Corporation Act or the Company’s certificate of
incorporation or bylaws by (i) facsimile telecommunication to the facsimile number provided below (or to any other facsimile number for the undersigned in the Company’s records), (ii) electronic mail to the electronic mail address provided
below (or to any other electronic mail address for the undersigned in the Company’s records), (iii) posting on an electronic network together with separate notice to the undersigned of such specific posting or (iv) any other form of
electronic transmission directed to the undersigned. This consent may be revoked by the undersigned by written notice to the Company.

  

	
	  

	(Print name of the warrant holder)
	
	  

	(Signature)
	
	  

	(Name and title of signatory, if applicable)
	
	  

	(Date)
	
	  

	(Fax number)
	
	  

	(Email address)


  

	1 	Note to Draft: Include if exercised pursuant to Section 2(a). 


  
 A-2 








 EXHIBIT B 

ASSIGNMENT FORM 
  

			
	ASSIGNOR:	  	  

		
	COMPANY:	  	OMEROS CORPORATION
		
	WARRANT:	  	THE WARRANT TO PURCHASE SHARES OF COMMON STOCK ISSUED ON APRIL 12, 2018 (THE “WARRANT”)
		
	DATE:	  	  


  

			
	(1)	 	Assignment. The undersigned registered holder of the Warrant (“Assignor”) assigns and transfers to the assignee named below (“Assignee”) all of the rights of Assignor under the
Warrant, with respect to the number of shares set forth below:

  

			
		
	Name of Assignee:	 	  

		
	Address of Assignee:	 	  

		
		 	  

		
	Number of Shares Assigned:	 	  



 and does irrevocably constitute and appoint
                             as attorney to make such transfer on the books of Omeros Corporation,
maintained for the purpose, with full power of substitution in the premises. 
  

			
	(2)	 	Obligations of Assignee. Assignee agrees to take and hold the Warrant and any shares of stock to be issued upon exercise of the rights thereunder (the “Securities”) subject to, and to be bound by, the
terms and conditions set forth in the Warrant to the same extent as if Assignee were the original holder thereof.

  

			
	(3)	 	[Investment Intent. Assignee represents and warrants that the Securities are being acquired for investment for its own account, not as a nominee or agent, and not with a view to, or for resale in connection with, the
distribution thereof, and that Assignee has no present intention of selling, granting any participation in, or otherwise distributing the shares, nor does it have any contract, undertaking, agreement or arrangement for the same, and all
representations and warranties set forth in Section 10 of the Warrant are true and correct as to Assignee as of the date hereof.]2

  

	2 	Note to Draft: Include to the extent required pursuant to Section 5(a). 


  
 B-1 








 Assignor and Assignee are signing this Assignment Form on the date first set forth above. 

 

					
	ASSIGNOR	 		 	ASSIGNEE
			
	  
 (Print name of
Assignor)
	 		 	  
 (Print name of
Assignee)

			
	  
 (Signature of
Assignor)
	 		 	  
 (Signature of
Assignee)

			
	  
 (Print name of
signatory, if applicable)
	 		 	  
 (Print name of
signatory, if applicable)

			
	  
 (Print title of
signatory, if applicable)
	 		 	  
 (Print title of
signatory, if applicable)

			
	 Address:
	 		 	Address:
			
	  
	 		 	  

			
	  
	 		 	  



  
 B-2