EX-4.1


 Exhibit 4.1 

CLOVIS ONCOLOGY, INC. 

and 
 THE BANK OF NEW
YORK MELLON TRUST COMPANY, N.A., as Trustee 
 INDENTURE 

Dated as of April 19, 2018 






 TABLE OF CONTENTS 

 

					
	 ARTICLE I DEFINITIONS AND INCORPORATION BY REFERENCE
	  	 	1	 
		
	 SECTION 1.01. Definitions
	  	 	1	 
	 SECTION 1.02. Incorporation by Reference of Trust Indenture Act
	  	 	3	 
	 SECTION 1.03. Rules of Construction
	  	 	4	 
		
	 ARTICLE II THE SECURITIES
	  	 	4	 
		
	 SECTION 2.01. Form and Dating
	  	 	4	 
	 SECTION 2.02. Amount Unlimited; Issuable in Series
	  	 	5	 
	 SECTION 2.03. Denominations
	  	 	6	 
	 SECTION 2.04. Execution and Authentication
	  	 	6	 
	 SECTION 2.05. Registrar and Paying Agent
	  	 	6	 
	 SECTION 2.06. Paying Agent to Hold Money in Trust
	  	 	7	 
	 SECTION 2.07. Securityholder Lists
	  	 	7	 
	 SECTION 2.08. Transfer and Exchange
	  	 	7	 
	 SECTION 2.09. Replacement Securities
	  	 	8	 
	 SECTION 2.10. Outstanding Securities
	  	 	8	 
	 SECTION 2.11. Temporary Securities
	  	 	8	 
	 SECTION 2.12. Cancellation
	  	 	8	 
	 SECTION 2.13. Defaulted Interest
	  	 	9	 
	 SECTION 2.14. CUSIP Numbers
	  	 	9	 
		
	 ARTICLE III REDEMPTION
	  	 	9	 
		
	 SECTION 3.01. Company’s Option to Redeem
	  	 	9	 
	 SECTION 3.02. Notices to Trustee
	  	 	9	 
	 SECTION 3.03. Selection of Securities to Be Redeemed
	  	 	10	 
	 SECTION 3.04. Notice of Redemption at the Company’s Option
	  	 	10	 
	 SECTION 3.05. Effect of Notice of Redemption
	  	 	10	 
	 SECTION 3.06. Deposit of Redemption Price
	  	 	11	 
	 SECTION 3.07. Holder’s Right to Require Redemption
	  	 	11	 
	 SECTION 3.08. Procedure for Requiring Redemption
	  	 	11	 
	 SECTION 3.09. Securities Redeemed in Part
	  	 	11	 
		
	 ARTICLE IV COVENANTS
	  	 	12	 
		
	 SECTION 4.01. Payment of Securities
	  	 	12	 
	 SECTION 4.02. Reporting
	  	 	12	 
	 SECTION 4.03. Corporate Existence
	  	 	12	 
	 SECTION 4.04. Compliance Certificate
	  	 	12	 
	 SECTION 4.05. Further Instruments and Acts
	  	 	12	 
		
	 ARTICLE V SUCCESSOR CORPORATION
	  	 	13	 
		
	 SECTION 5.01. Company May Consolidate, etc., Only on Certain Terms
	  	 	13	 
	 SECTION 5.02. Successor Corporation Substituted
	  	 	13	 
		
	 ARTICLE VI DEFAULTS AND REMEDIES
	  	 	13	 
		
	 SECTION 6.01. Events of Default
	  	 	13	 


  
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	 SECTION 6.02. Acceleration
	  	 	15	 
	 SECTION 6.03. Other Remedies
	  	 	15	 
	 SECTION 6.04. Waiver of Existing Defaults
	  	 	15	 
	 SECTION 6.05. Control by Majority
	  	 	16	 
	 SECTION 6.06. Payments of Securities on Default; Suit Therefor
	  	 	16	 
	 SECTION 6.07. Limitation on Suits
	  	 	16	 
	 SECTION 6.08. Rights of Holders to Receive Payment and to Demand Conversion
	  	 	17	 
	 SECTION 6.09. Collection Suit by Trustee
	  	 	17	 
	 SECTION 6.10. Trustee May File Proofs of Claim
	  	 	17	 
	 SECTION 6.11. Restoration of Positions
	  	 	17	 
	 SECTION 6.12. Priorities
	  	 	17	 
	 SECTION 6.13. Undertaking for Costs
	  	 	18	 
	 SECTION 6.14. Stay, Extension or Usury Laws
	  	 	18	 
	 SECTION 6.15. Liability of Stockholders, Officers, Directors and Incorporators
	  	 	19	 
		
	 ARTICLE VII TRUSTEE
	  	 	19	 
		
	 SECTION 7.01. Duties of Trustee
	  	 	19	 
	 SECTION 7.02. Rights of Trustee
	  	 	20	 
	 SECTION 7.03. Individual Rights of Trustee
	  	 	22	 
	 SECTION 7.04. Trustee’s Disclaimer
	  	 	22	 
	 SECTION 7.05. Notice of Defaults
	  	 	22	 
	 SECTION 7.06. Reports by Trustee
	  	 	22	 
	 SECTION 7.07. Compensation and Indemnity
	  	 	23	 
	 SECTION 7.08. Replacement of Trustee
	  	 	24	 
	 SECTION 7.09. Successor Trustee by Merger, etc
	  	 	25	 
	 SECTION 7.10. Eligibility; Disqualification
	  	 	25	 
	 SECTION 7.11. Preferential Collection of Claims
	  	 	25	 
		
	 ARTICLE VIII DISCHARGE OF INDENTURE
	  	 	25	 
		
	 SECTION 8.01. Termination of the Company’s Obligations
	  	 	25	 
	 SECTION 8.02. Application of Trust Money
	  	 	26	 
	 SECTION 8.03. Repayment to the Company
	  	 	26	 
	 SECTION 8.04. Deposited Money and U.S. Government Obligations to Be Held in Trust
	  	 	26	 
		
	 ARTICLE IX AMENDMENTS, SUPPLEMENTS AND WAIVERS
	  	 	27	 
		
	 SECTION 9.01. Without Consent of Holders
	  	 	27	 
	 SECTION 9.02. With Consent of Holders
	  	 	27	 
	 SECTION 9.03. Compliance with Trust Indenture Act
	  	 	28	 
	 SECTION 9.04. Revocation and Effect of Consents
	  	 	28	 
	 SECTION 9.05. Notation on or Exchange of Securities
	  	 	29	 
	 SECTION 9.06. Trustee to Sign Amendments, etc
	  	 	29	 
		
	 ARTICLE X CONVERSION OR EXCHANGE OF SECURITIES
	  	 	29	 
		
	 SECTION 10.01. Provisions Relating to Conversion or Exchange of Securities
	  	 	29	 


  
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	 ARTICLE XI SINKING OR PURCHASE FUNDS
	  	 	29	 
		
	 SECTION 11.01. Provisions Relating to Sinking or Purchase Funds
	  	 	29	 
		
	 ARTICLE XII CONCERNING THE HOLDERS
	  	 	30	 
		
	 SECTION 12.01. Action by Holders
	  	 	30	 
	 SECTION 12.02. Proof of Execution by Holders
	  	 	30	 
	 SECTION 12.03. Who Are Deemed Absolute Owners
	  	 	30	 
	 SECTION 12.04. Revocation of Consents; Future Holders Bound
	  	 	31	 
		
	 ARTICLE XIII MISCELLANEOUS
	  	 	31	 
		
	 SECTION 13.01. Trust Indenture Act Controls
	  	 	31	 
	 SECTION 13.02. Supplemental Indentures Contract
	  	 	31	 
	 SECTION 13.03. Notices
	  	 	31	 
	 SECTION 13.04. Communication by Holders with Other Holders
	  	 	33	 
	 SECTION 13.05. Certificate and Opinion as to Conditions Precedent
	  	 	33	 
	 SECTION 13.06. When Treasury Securities Disregarded
	  	 	34	 
	 SECTION 13.07. Rules by Trustee, Paying Agent, Registrar
	  	 	34	 
	 SECTION 13.08. Legal Holidays
	  	 	34	 
	 SECTION 13.09. Governing Law and Submission to Jurisdiction
	  	 	34	 
	 SECTION 13.10. Actions by the Company
	  	 	34	 
	 SECTION 13.11. No Adverse Interpretation of Other Agreements
	  	 	35	 
	 SECTION 13.12. Successors
	  	 	35	 
	 SECTION 13.13. Duplicate Originals
	  	 	35	 
	 SECTION 13.14. Table of Contents, Headings, etc
	  	 	35	 
	 SECTION 13.15. Authenticating Agent
	  	 	35	 
	 SECTION 13.16. Execution in Counterparts
	  	 	36	 
	 SECTION 13.17. Severability
	  	 	36	 
	 SECTION 13.18. Waiver of Jury Trial
	  	 	36	 
	 SECTION 13.19. Force Majeure
	  	 	36	 
	 SECTION 13.20. FATCA
	  	 	37	 


  
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 CROSS REFERENCE TABLE 

 

			
	TIA Section	  	Indenture Section
	 310(a)(1)
	  	7.10
	 (a)(2)
	  	7.10
	 (a)(3)
	  	N.A.
	 (a)(4)
	  	N.A.
	 (a)(5)
	  	N.A.
	 (b)
	  	7.08; 7.10
	 311(a)
	  	7.11
	 (b)
	  	7.11
	 312(a)
	  	2.07
	 (b)
	  	13.04
	 (c)
	  	13.04
	 313(a)
	  	7.06
	 (b)(1)
	  	7.06
	 (b)(2)
	  	7.06
	 (c)
	  	7.06
	 (d)
	  	7.06
	 314(a)(1)
	  	4.02
	 (a)(2)
	  	4.02
	 (a)(4)
	  	4.04
	 (b)
	  	N.A.
	 (c)
	  	2.04; 7.02(b); 8.01
	 (c)(1)
	  	13.05
	 (c)(2)
	  	13.05
	 (c)(3)
	  	13.05
	 (d)
	  	N.A.
	 (e)
	  	4.04; 13.05
	 (f)
	  	13.05
	 315(a)(1)
	  	6.05; 7.01(b)(i)
	 (a)(2)
	  	7.01(b)(ii)
	 (b)
	  	7.05; 13.03
	 (c)
	  	7.01(a)
	 (d)(1)
	  	7.01(b)
	 (d)(2)
	  	7.01(c)
	 (d)(3)
	  	6.05; 7.01(d)
	 (e)
	  	6.13
	 316(a)(last sentence)
	  	13.06
	 (a)(1)(A)
	  	6.05
	 (a)(1)(B)
	  	6.04
	 (a)(2)
	  	N.A.
	 (b)
	  	6.08
	 (c)
	  	9.02; 13.03
	 317(a)(1)
	  	6.09
	 (a)(2)
	  	6.10
	 (b)
	  	2.06
	 318(a)
	  	1.02; 13.01

 N.A. means Not Applicable. 

Note: This cross-reference table shall not, for any purpose, be deemed to be a part of the Indenture. 

  
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 INDENTURE, dated as of April 19, 2018 between Clovis Oncology, Inc. (the
“Company”), a Delaware corporation having its principal office at 5500 Flatiron Parkway, Suite 100, Boulder, Colorado 80301, and The Bank of New York Mellon Trust Company, N.A. with its principal office at 400 South Hope Street, Los
Angeles, California 90071 (the “Trustee”). Each party agrees as follows for the benefit of each other party and for the equal and ratable benefit of the Holders of the Company’s debentures, notes or other evidences of unsecured
indebtedness to be issued in one or more series (“Securities”): 
 ARTICLE I 

DEFINITIONS AND INCORPORATION BY REFERENCE 

SECTION 1.01. Definitions. 

“Bankruptcy Law” has the meaning provided in Section 6.01. 

“Board Resolution” means a resolution by the Board of Directors of the Company certified by its Secretary or an Assistant
Secretary as being duly adopted and in full force and effect. 
 “Business Day” means any day other than a Saturday, a
Sunday or a day on which the Federal Reserve Bank of New York is authorized or required by law or executive order to close or be closed. 

“Capital Stock” means, for any entity, any and all shares, interests, rights to purchase, warrants, options, participations
or other equivalents of or interests in (however designated) stock issued by that entity. 
 “Common Stock” means the
common stock, par value $.001 per share, of the Company, as that stock may be reconstituted from time to time. 
 “Company”
means the Person named as such in this Indenture until a successor replaces it and after that means the successor. 
 “Company
Order” means a written order of the Company, signed by (a) the Company’s Chief Executive Officer, Chief Financial Officer, President or any Executive Vice President and (b) any such other Officer designated in clause
(a) of this definition or the Company’s Treasurer or Assistant Treasurer or Secretary or any Assistant Secretary, and delivered to the Trustee. 

“Corporate Trust Office” means the office of the Trustee at which at any particular time its corporate trust business is
principally administered (which at the date of this Indenture is at the location set forth in the first paragraph of this Indenture), Attention: Corporate Trust, or such other address as the Trustee may designate from time to time by notice to
Holders and the Company, or the principal corporate trust office of any successor Trustee (or such other address as such successor Trustee may designate from time to time by notice to the Holders and the Company). 

“Corporation” includes corporations, associations, companies and business trusts. 

“Custodian” has the meaning provided in Section 6.01. 

  
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 “Default” means any event that, upon the giving of notice or passage of time, or
both, would be an Event of Default. 
 “Depositary” means The Depository Trust Company, its nominees and their respective
successors and assigns. 
 “$” means the lawful currency of the United States. 

“Event of Default” has the meaning provided in Section 6.01. 

“Global Security” has the meaning provided in Section 12.03. 

“Holder” or “Securityholder” means a Person in whose name a Security is registered on the Registrar’s
books. 
 “Indenture” means this Indenture as amended or supplemented from time to time and will include the form and terms
of the Securities of each series established as contemplated by Section 2.01. 
 “Interest Payment Date” means the
date on which an installment of interest on the Securities is due and payable. 
 “Maturity Date” means the date the
principal of Securities is due and payable. 
 “Officer” means, with respect to the Company, the President, the Chief
Executive Officer, the Chief Financial Officer, the Treasurer, the Secretary or any Executive Vice President. 
 “Officer’s
Certificate” when used with respect to the Company means a certificate signed by an Officer, and delivered to the Trustee. Each such certificate will comply with Section 314 of the TIA and include the statements described in
Section 13.05. 
 “Opinion of Counsel” means an opinion in writing signed by legal counsel, who may be an employee of
or counsel to the Company, that is delivered to the Trustee, which opinion may contain customary exceptions and qualifications as to the matters set forth therein. Each such opinion will include the statements described in Section 13.05 if and
to the extent required by that Section. 
 “Paying Agent” has the meaning provided in Section 2.05. 

“Person” means any individual, corporation, limited liability company, partnership, joint venture, joint-stock company,
trust, unincorporated organization or government or any government agency or political subdivision. 
 “Registrar” has the
meaning provided in Section 2.05. 
 “SEC” means the Securities and Exchange Commission. 

“Securities” has the meaning set forth in the first paragraph of this Indenture. 

  
 - 2 - 







 “Securities Act of 1933” means the Securities Act of 1933, as amended. 

“Securities Exchange Act of 1934” means the Securities Exchange Act of 1934, as amended. 

“State” means any state of the United States or the District of Columbia. 

“Subsidiary” means, with respect to any Person, any corporation, association, partnership or other business entity of which
more than 50% of the total voting power of shares of Capital Stock or other interests (including partnership interests) entitled (without regard to the occurrence of any contingency) to vote in the election of directors, managers, general partners
or trustees thereof is at the time owned or controlled, directly or indirectly, by (i) such Person; (ii) such Person and one or more Subsidiaries of such Person; or (iii) one or more Subsidiaries of such Person. 

“Supplemental Indenture” means an indenture between the Company and the Trustee which supplements this Indenture. 

“TIA” means the Trust Indenture Act of 1939, as amended, as in effect on the date of this Indenture, except to the extent
that the Trust Indenture Act or any amendment thereto expressly provides for application of the Trust Indenture Act as in effect on another date. 

“Trustee” means the Person named as such in this Indenture and, subject to the provisions of Article VII, any successor to
that person. 
 “Trust Officer” means, when used with respect to the Trustee, any officer assigned to the corporate trust
department of the Trustee, who shall have direct responsibility for the administration of this Indenture, and for the purposes of Section 7.01(c) and Section 7.05 shall also include any other officer of the Trustee to whom any corporate
trust matter is referred because of such officer’s knowledge of and familiarity with the particular subject. 
 “United
States” means the United States of America. 
 “U.S. Government Obligations” means: 

 

	 	(1)	direct obligations of the United States for the payment of which its full faith and credit is pledged; or 

  

	 	(2)	obligations of a person controlled or supervised by and acting as an agency or instrumentality of the United States the payment of which is unconditionally guaranteed as a full faith and credit obligation by the United
States. 

 SECTION 1.02. Incorporation by Reference of Trust Indenture Act. Whenever this Indenture refers to a
provision of the TIA, the provision is incorporated by reference in and made a part of this Indenture. In addition, the provisions of Sections 310 to and including 317 of the TIA that impose duties on any person are incorporated by reference in, and
form a part of, this Indenture. The following TIA terms mean the following when used in this Indenture: 

  
 - 3 - 







 “Commission” means the SEC; 

“indenture securities” means the Securities; 

“indenture securityholder” means a Holder or Securityholder; 

“indenture to be qualified” means this Indenture; 

“indenture trustee” or “institutional trustee” means the Trustee; and 

“obligor” on the indenture securities means the Company. 

All other TIA terms used in this Indenture that are defined in the TIA, defined in the TIA by reference to another statute or defined by SEC
rule have the meanings assigned to them. 
 SECTION 1.03. Rules of Construction. Unless the context otherwise requires: 

 

	 	(1)	a term has the meaning assigned to it; 

  

	 	(2)	an accounting term not otherwise defined has the meaning assigned to it in accordance with generally accepted accounting principles in the United States; 


 

	 	(3)	“or” is not exclusive; 

  

	 	(4)	the words “herein”, “hereof” and “hereunder” and other words of similar import refer to this Indenture as a whole and not to any particular Article, Section or other subdivision;


  

	 	(5)	words importing any gender include the other genders; 

  

	 	(6)	references to “writing” include printing, typing, lithography and other means of reproducing words in a visible form; 

  

	 	(7)	the words “including,” “includes” and “include” shall be deemed to be followed by the words “without limitation”; and 


 

	 	(8)	words in the singular include the plural, and in the plural include the singular. 

 ARTICLE II

 THE SECURITIES 
 SECTION
2.01. Form and Dating. (a) The Securities of each series will be substantially in the form established by a Supplemental Indenture relating to the Securities of that series. The Securities may have notations, legends or endorsements
required by law, stock exchange rules or usage. The Company will approve the form of the Securities and any notation, legend or endorsement on them. Each Security will be dated the date of its authentication. 

(b) The Trustee’s certificate of authentication will be substantially in the form of Exhibit A. 

  
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 SECTION 2.02. Amount Unlimited; Issuable in Series. The aggregate principal amount of the
Securities that may be authenticated and delivered under this Indenture is unlimited. The Securities may be issued in one or more series. Prior to the issuance of Securities of a series, the Company and the Trustee will execute a Supplemental
Indenture that will set forth as to the Securities of that series, to the extent applicable: 
  

	 	(1)	the title of the Securities; 

  

	 	(2)	any limit upon the aggregate principal amount of Securities which may be issued; 

  

	 	(3)	the date or dates on which the Securities will mature and the amounts to be paid upon maturity of the Securities; 

  

	 	(4)	the rate or rates (which may be fixed or variable) at which the Securities will bear interest, if any, or contingent interest, if any, the dates from which interest will accrue, the dates on which interest will be
payable and the record date for the interest payable on any interest payment date; 

  

	 	(5)	the currency or currencies in which principal, premium, if any, and interest, if any, will be payable; 

  

	 	(6)	the place or places where principal of, premium, if any, and interest, if any, on the Securities will be payable; 

  

	 	(7)	any provisions regarding the right of the Company to redeem or repurchase Securities or of holders to require the Company to redeem or repurchase Securities; 


 

	 	(8)	whether the Securities are senior or subordinated debt securities, and if subordinated debt securities, the terms of such subordination; 


 

	 	(9)	the right, if any, of holders of the Securities to convert them into common stock or other securities of the Company, including any contingent conversion provisions and any provisions intended to prevent dilution of
those conversion rights; 

  

	 	(10)	any provisions by which the Company will be required or permitted to make payments to a sinking fund which will be used to redeem Securities or a purchase fund which will be used to purchase Securities;


  

	 	(11)	any index or formula used to determine the required payments of principal, premium, if any, or interest, if any; 

  

	 	(12)	the percentage of the principal amount of the Securities that is payable if maturity of the Securities is accelerated because of a default; 


 

	 	(13)	any special or modified events of default or covenants with respect to the Securities; 

  

	 	(14)	any other terms of the Securities, which may be different from the terms set forth in this Indenture. 


  
 - 5 - 







 SECTION 2.03. Denominations. Unless otherwise provided in the Supplemental Indenture
relating to a series of Securities, the Securities of each series will be issuable in registered form without coupons in denominations of $1,000 and multiples of $1,000. 

SECTION 2.04. Execution and Authentication. The Securities of each series shall be signed in the name and on behalf of the Company by
the manual or facsimile signature of its Chief Executive Officer, President, Chief Financial Officer, Treasurer, Secretary or any of its Executive Vice Presidents. 

At any time and from time to time after the execution and delivery of this Indenture, the Company may deliver Securities executed by the
Company to the Trustee for authentication, together with a Company Order for the authentication and delivery of such Securities, and the Trustee in accordance with such Company Order shall authenticate and deliver such Securities. A Security will
not be valid until an authorized signatory of the Trustee manually signs the certificate of authentication on the Security. The signature will be conclusive evidence that the Security has been authenticated under this Indenture. 

In case any Officer of the Company who shall have signed any of the Securities shall cease to be such Officer before the Securities so signed
shall have been authenticated and delivered by the Trustee, or disposed of by the Company, such Securities nevertheless may be authenticated and delivered or disposed of as though the Person who signed such Securities had not ceased to be such
Officer of the Company; and any Security may be signed on behalf of the Company by such persons as, at the actual date of the execution of such Security, shall be the Officers of the Company, although at the date of the execution of this Indenture
any such Person was not such an Officer. 
 SECTION 2.05. Registrar and Paying Agent. The Company will maintain an office or agency
where Securities of each series may be presented for conversion, registration of transfer or for exchange (the “Registrar”) and an office or agency where Securities of each series may be presented for payment (“Paying
Agent”). The Registrar will keep a register of the Securities of each series and of their transfer and exchange. The Company may have one or more co-registrars and one or more additional paying
agents. The term “Paying Agent” includes any additional paying agent. 
 The Company will enter into an appropriate agency
agreement with any Registrar, Paying Agent or co-registrar not a party to this Indenture that will incorporate the terms of the TIA. The agreement will implement the provisions of this Indenture that relate to
that agent. The Company will notify the Trustee of the name and address of any such agent. If the Company fails to maintain a Registrar or Paying Agent, the Trustee will act as such. The Company or any Subsidiary may act as Paying Agent, Registrar, co-registrar or transfer agent. 
 The Company initially appoints the Trustee to act as Registrar and
Paying Agent in connection with the Securities of each series, except in instances in which the Supplemental Indenture relating to a series of Securities appoints a different Registrar or Paying Agent. 

  
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 SECTION 2.06. Paying Agent to Hold Money in Trust. Prior to each due date of the principal
of, premium, if any, or interest, if any, on any Security, the Company will deposit with the Paying Agent a sum sufficient to pay that principal, premium or interest when due. The Paying Agent will hold in trust for the benefit of the Holders of the
Securities of a series, and if the Paying Agent is not the Trustee, in trust for the benefit of the Trustee, all sums held by the Paying Agent for the payment of principal, premium or interest on the Securities of that series and, in the case of a
Paying Agent other than the Trustee, the Paying Agent will give the Trustee notice of any default by the Company in making any such payment. If the Company or a Subsidiary acts as Paying Agent, it will segregate the money held by it as Paying Agent
and hold it as a separate trust fund. The Company at any time may require a Paying Agent to pay all money held by it to the Trustee and to account for any funds disbursed by the Paying Agent. Upon complying with this Section, the Paying Agent will
have no further liability for the money. 
 SECTION 2.07. Securityholder Lists. The Trustee will preserve in as current a form as is
reasonably practicable the most recent list available to it of the names and addresses of the Holders of the Securities of each series. If the Trustee is not the Registrar, in accordance with Section 312(a) of the TIA, the Company will furnish
to the Trustee in writing at least five Business Days before each Interest Payment Date and at such other times as the Trustee may request in writing within 30 days after the receipt by the Company of any such request all information in the
possession or control of the Company or its Paying Agent as to the names and addresses of Holders of the Securities of a series. 
 SECTION
2.08. Transfer and Exchange. Unless otherwise provided in the Supplemental Indenture relating to Securities of a series, Securities which are issued in registered form will be transferred only upon the surrender of the Securities for
registration of transfer. When a Security is presented to the Registrar or a co-registrar with a request to register a transfer, the Registrar will register the transfer as requested if the requirements of
Article 8 of the New York Uniform Commercial Code are met. When Securities are presented to the Registrar or a co-registrar with a request to exchange them for an equal principal amount of Securities of the
same series of other denominations, the Registrar will make the exchange as requested if the same requirements are met. To permit registration of transfers and exchanges, the Company will execute and the Trustee will authenticate Securities at the
Registrar’s or co-registrar’s request. The Company will not charge a fee for transfers or exchanges, but the Company may require payment from the applicable Securityholder of a sum sufficient to
cover any tax or other governmental charge and any other expenses (including fees and expenses of the Trustee) that may be imposed in connection with any registration of transfer or exchange of the Securities, other than exchanges pursuant to
Sections 2.11, 3.09 and 9.05 not involving any transfer. 
 The Company will not be required to make, and the Registrar need not register,
transfers or exchanges of (i) Securities selected for redemption (except, in the case of Securities to be redeemed in part, transfers or exchanges of the portion of the Securities not to be redeemed) or (ii) any Securities of a series for
a period of 15 days before the first mailing of a notice of the Securities of that series which are to be redeemed. 
 Prior to the due
presentation for registration or transfer of any Security which was issued in registered form, the Company, the Trustee, the Paying Agent, any authenticating agent, the Registrar or any co-registrar may deem
and treat the person in whose name the Security is registered as the absolute owner of the Security for all purposes, and none of the Company, the Trustee, the Paying Agent, the Registrar or any co-registrar
will be affected by notice to the contrary. 

  
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 SECTION 2.09. Replacement Securities. If a mutilated Security which had been issued in
registered form is surrendered to the Registrar or if the Holder presents evidence to the satisfaction of the Company and the Trustee that a Security which had been issued in registered form has been lost or destroyed, the Company will issue and the
Trustee or an authenticating agent appointed by the Trustee will authenticate a replacement Security of the same series if the requirements of Section 8-405 of the New York Uniform Commercial Code are met
and the Holder satisfies any other reasonable requirements of the Trustee. If required by the Trustee or the Company, the replacement Security will not be issued until the Holder furnishes an indemnity bond sufficient in the judgment of the Company
and the Trustee to protect the Company, the Trustee, and if applicable, the authenticating agent, the Paying Agent and the Registrar or any co-registrar from any loss which any of them may suffer if the
Security is replaced. The Company may charge the Holder for its expenses in replacing a Security. 
 Every replacement Security will be an
obligation of the Company, even if the replaced Security is subsequently found. 
 SECTION 2.10. Outstanding Securities. The
Securities outstanding at any time will be all the Securities authenticated by the Trustee, except those cancelled by it, those delivered to it for cancellation and those described in this Section as not outstanding. A Security does not cease to be
outstanding because the Company or its affiliate holds the Security. 
 If a Security is replaced pursuant to Section 2.09, it ceases
to be outstanding unless the Trustee and the Company receive proof satisfactory to them that the replaced Security is held by a protected purchaser (in which case the replaced Security will be treated as outstanding to the extent permitted by Section 8-210 of the New York Uniform Commercial Code). 
 If the Paying Agent (other than the
Company or a Subsidiary) segregates and holds in trust, in accordance with this Indenture, on a redemption date or Maturity Date money sufficient to pay all principal, premium, if any, and interest, if any, payable on that date with respect to the
Securities to be redeemed or maturing, as the case may be, then on that date those Securities will cease to be outstanding and interest on them will cease to accrue. 

SECTION 2.11. Temporary Securities. Until definitive Securities of a series are ready for delivery, the Company may prepare and the
Trustee or an authenticating agent appointed by the Trustee will authenticate temporary Securities of that series. Temporary Securities will be substantially in the form of definitive Securities but may have variations that the Company considers
appropriate for temporary Securities. Without unreasonable delay, the Company will prepare and the Trustee or an authenticating agent appointed by the Trustee will authenticate definitive Securities and deliver them in exchange for temporary
Securities. 
 SECTION 2.12. Cancellation. The Company at any time may deliver Securities of a series to the Trustee for cancellation
and the Trustee will reduce accordingly the aggregate amount of the Securities of that series which are outstanding. The Registrar and the Paying Agent will forward to the Trustee any Securities surrendered to them for registration of transfer,
exchange, payment, or conversion. The Trustee and no one else will cancel and dispose of all Securities surrendered for registration of transfer, exchange, 

  
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payment, conversion or cancellation in accordance with its procedures for the disposition of cancelled securities and deliver certificates of such disposition to the Company unless the Company
directs the Trustee to deliver the cancelled Securities to the Company. Subject to Section 2.09, the Company may not issue new Securities of a series to replace Securities of the series it has redeemed, paid, converted or delivered to the
Trustee for cancellation. 
 SECTION 2.13. Defaulted Interest. If the Company defaults in a payment of interest on the Securities of
a series, it will pay defaulted interest (plus interest on such defaulted interest to the extent lawful) to the persons who are Holders of the Securities of that series on a subsequent special record date, which date will be at least five Business
Days prior to the payment date. The Company will fix the special record date and payment date, and, at least 15 days before the special record date, the Company will mail to each Holder of Securities of that series a notice that states the special
record date, the payment date and the amount of defaulted interest and any interest on that defaulted interest which is to be paid. Notwithstanding the foregoing, the Company may pay defaulted interest in any other lawful manner. 

SECTION 2.14. CUSIP Numbers. The Company in issuing the Securities may use “CUSIP,” “ISIN” or other similar numbers
(if then generally in use), and, if so, the Trustee shall use “CUSIP,” “ISIN” or other similar numbers, as the case may be, in notices of redemption or exchange as a convenience to Holders; provided that any such notice may state
that no representation is made as to the correctness of such numbers either as printed on the Securities or as contained in any notice of a redemption and that reliance may be placed only on the other identification numbers printed on the
Securities, and any such redemption shall not be affected by any defect in or omission of such numbers. The Company will promptly notify the Trustee in writing of any change in the “CUSIP,” “ISIN” or other similar numbers. 

ARTICLE III 
 REDEMPTION 

SECTION 3.01. Company’s Option to Redeem. The Company will have the option to redeem Securities of a series only to
the extent, if any, and only on the terms, set forth in the Supplemental Indenture relating to the Securities of that series. If the Company has the option to redeem Securities of a series, unless otherwise provided in the Supplemental Indenture
relating to the series, the terms of the redemption will include those set forth in Sections 3.02 through 3.06 and 3.08. 
 SECTION 3.02.
Notices to Trustee. If the Company elects to redeem Securities of a series, it will notify the Trustee of the redemption date and the principal amount and series of Securities to be redeemed. The Company will give each notice provided for in
this Section not less than 35 days before the redemption date (or such shorter period of time as may be acceptable to the Trustee). If fewer than all the Securities of a series are to be redeemed, the record date for determining which Securities of
the series are to be redeemed will be selected by the Company, which will give notice of the record date to the Trustee at least 15 days before the record date. 

  
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 SECTION 3.03. Selection of Securities to Be Redeemed. If fewer than all the Securities of
a series are to be redeemed at the Company’s option, such Securities or portions thereof shall be selected in accordance with the procedures of the Depositary in the case of global Securities, and in the case of Securities in definitive form
the Trustee will select the Securities of that series to be redeemed by lot. Provisions of this Indenture that apply to Securities called for redemption also apply to portions of Securities called for redemption. The Trustee will notify the Company
promptly of the Securities or portions of Securities to be redeemed. 
 SECTION 3.04. Notice of Redemption at the
Company’s Option. At least 30 days and not more than 60 days before a date set for redemption at the Company’s option, the Company will deliver a notice of redemption to each Holder of Securities to be redeemed in whole
or in part. The notice will identify the principal amount and series of each Security to be redeemed and will state: 
  

	 	(1)	the redemption date; 

  

	 	(2)	the redemption price plus accrued interest, if any; 

  

	 	(3)	the name and address of the Paying Agent; 

  

	 	(4)	that Securities called for redemption in whole or in part must be surrendered to the Paying Agent to collect the redemption price plus accrued interest, if any; 


 

	 	(5)	that, unless the Company defaults in making the redemption payment, interest on Securities (or portions of Securities) called for redemption will cease to accrue on the redemption date and, if applicable, that those
Securities (or the portions of then called for redemption) will cease on the redemption date (or such other date as is provided in the Supplemental Indenture relating to the Securities) to be convertible into, or exchangeable for, other securities
or assets; 

  

	 	(6)	if applicable, the current conversion or exchange price; and 

  

	 	(7)	the CUSIP, ISIN or other similar numbers, if any, assigned to such Securities. 

 At the
Company’s request delivered at least five (5) days prior to the date such notice of redemption is to be given (unless a shorter period shall be acceptable to the Trustee), the Trustee will give the notice of redemption in the
Company’s name and at the Company’s expense. In such event, the Company will provide the Trustee with the information required by clauses (1) through (3), (6) and (7). 

SECTION 3.05. Effect of Notice of Redemption. Once notice of redemption is sent, Securities, or portions of Securities called for
redemption will become due and payable on the redemption date and at the redemption price. Upon surrender to the Paying Agent, those Securities will be paid at the redemption price, plus accrued and unpaid interest to the redemption date. On and
after the date fixed for redemption (unless the Company defaults in the payment of the redemption price, together with interest accrued to the redemption date) interest on the Securities, or portions of them, which are redeemed will cease to accrue
and any right to convert those Securities into, or exchange them for, other securities or assets will terminate and those Securities will cease to be convertible or exchangeable. Failure to give notice or any defect in the notice to any Holder will
not affect the validity of the notice to any other Holder. 

  
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 SECTION 3.06. Deposit of Redemption Price. No later than the Business Day prior to the
redemption date specified in a notice of redemption, the Company will deposit with the Paying Agent (or, if the Company or a Subsidiary is the Paying Agent, segregate and hold in trust) money sufficient to redeem on the redemption date all the
Securities called for redemption on that redemption date at the appropriate redemption price, together with accrued interest to the redemption date, other than Securities or portions of Securities called for redemption which have been delivered by
the Company to the Trustee for cancellation or Securities which have been surrendered for conversion or exchange. If any Securities called for redemption are converted or exchanged, any money deposited with the Paying Agent for redemption of those
Securities will be paid to the Company upon its request, or, if the money is held in trust by the Company or a Subsidiary as Paying Agent, the money will be discharged from the trust. 

SECTION 3.07. Holder’s Right to Require Redemption. Holders of Securities of a series will have the right to require
the Company to redeem those Securities only to the extent, and only on the terms, set forth in the Supplemental Indenture relating to the Securities of that series. If Holders of Securities of a series have the right to require the Company to redeem
those Securities, unless otherwise provided in the Supplemental Indenture relating to the Securities of that series, the terms of the redemption will include those set forth in Section 3.08. 

SECTION 3.08. Procedure for Requiring Redemption. If a Holder has the right to require the Company to redeem Securities, to exercise
that right, the Holder must deliver the Securities to the Paying Agent, endorsed for transfer and with the form on the reverse side entitled “Option to Require Redemption” completed. Delivery of Securities to the Paying Agent as provided
in this Section will constitute an irrevocable election to cause the specified principal amount of Securities to be redeemed. When Securities are delivered to the Paying Agent as provided in this Section, unless the Company fails to make the
payments due as a result of the redemption within 20 days after the Securities are delivered to the Paying Agent as provided in this Section interest on the Securities will cease to accrue and, if the Securities are convertible or exchangeable, the
Holder’s right to convert or exchange the Securities will terminate. 
 The Company’s determination of all questions regarding the
validity, eligibility (including time of receipt of Securities delivered by the Holders) and acceptance of any Security for redemption will be final and binding. 

SECTION 3.09. Securities Redeemed in Part. Upon surrender of a Security that is redeemed in part, the Company will execute and the
Trustee will authenticate and deliver to the Holder (at the Company’s expense) a new Security equal of the same series in principal amount equal to the unredeemed portion of the Security which was surrendered. 

  
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 ARTICLE IV 

COVENANTS 
 SECTION 4.01.
Payment of Securities. The Company will promptly pay or cause to be paid the principal of, premium, if any, and interest, if any, on each of the Securities of a series at the places and time and in the manner provided in the Securities and in
the Supplemental Indenture relating to the series. An installment of principal, premium or interest will be considered paid on the date it is due if the Trustee or Paying Agent holds on that date in accordance with this Indenture or the applicable
Supplemental Indenture money designated for and sufficient to pay the installment then due. 
 The Company will pay or cause to be paid
interest on overdue principal at the rate specified in the Securities; it will also pay interest on overdue installments of interest at the same rate (or such other rate as is provided in the applicable Supplemental Indenture), to the extent lawful.

 SECTION 4.02. Reporting. The Company will file with the Trustee within 15 days after filing with the SEC, copies of its annual
reports and of the information, documents, and other reports (or copies of such portions of any of the foregoing as the SEC may by rules and regulations prescribe) that the Company is required to file with the SEC pursuant to Section 13 or
15(d) of the Securities Exchange Act of 1934 (the “Exchange Act”). Any such document or report that the Company files with the Commission via the Commission’s EDGAR system shall be deemed to be filed with the Trustee for
purposes of this Section 4.02 at the time such documents are filed via the EDGAR system. 
 Delivery of such reports, information and
documents to the Trustee is for informational purposes only and the Trustee’s receipt of such shall not constitute actual or constructive notice of any information contained therein or determinable from information contained therein, including
the Company’s compliance with any of its covenants hereunder (as to which the Trustee is entitled to rely exclusively on an Officer’s Certificate). 

SECTION 4.03. Corporate Existence. Subject to Article V, the Company will do or cause to be done all things necessary to preserve and
keep in full force and effect its corporate existence. 
 SECTION 4.04. Compliance Certificate. The Company will deliver to the
Trustee within 120 days after the end of each year an Officer’s Certificate stating that in the course of the performance by the signers of their duties as Officers of the Company they would normally have knowledge of any default by the Company
and whether or not the signers know of any default that occurred during such year. If they do, the certificate will describe the default, its status and what action the Company is taking or proposes to take with respect thereto. The Company also
will comply with TIA Section 314(a)(4). 
 SECTION 4.05. Further Instruments and Acts. Upon request of the Trustee, the Company
will execute and deliver such further instruments and do such further acts as may be reasonably necessary or proper to carry out more effectively the purpose of this Indenture. 

  
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 ARTICLE V 

SUCCESSOR CORPORATION 
 SECTION
5.01. Company May Consolidate, etc., Only on Certain Terms. The Company will not consolidate with or merge into any other corporation or convey, transfer or lease all or substantially all of its properties and assets to another Person,
unless: 
  

	 	(1)	the corporation formed by the consolidation or into which the Company is merged or the person which acquires by conveyance or transfer, or which leases, the properties and assets of the Company substantially as an
entirety will be a corporation organized and existing under the laws of the United States of America, a State of the United States of America or the District of Columbia and expressly assumes, by one or more supplemental indentures, executed and
delivered to the Trustee, in form satisfactory to the Trustee, the due and punctual payment of the principal of, premium, if any, and interest, if any, on all the Securities of each series and the performance of every covenant of this Indenture and
of all Supplemental Indentures to be performed or observed by the Company; 

  

	 	(2)	with regard to each series of Securities, immediately after giving effect to the transaction, no Event of Default with respect to that series of Securities, and no event which, after notice or lapse of time or both,
would become an Event of Default with respect to that series of Securities, will have occurred and be continuing; and 

  

	 	(3)	the Company has delivered to the Trustee an Officer’s Certificate, and an Opinion of Counsel, each stating that the consolidation, merger, conveyance, transfer or lease and the supplemental indenture (or the
supplemental indentures together) comply with this Article and that all the conditions precedent relating to the transaction set forth in this Section have been fulfilled. 


SECTION 5.02. Successor Corporation Substituted. Upon any event described in Section 5.01, the successor corporation will succeed
to, and be substituted for, and may exercise every right and power of, the Company under this Indenture and all the Supplemental Indentures relating to outstanding series of Securities, and the predecessor corporation will be relieved of all
obligations and covenants under this Indenture and each of those Supplemental Indentures. 
 ARTICLE VI 

DEFAULTS AND REMEDIES 
 SECTION
6.01. Events of Default. An “Event of Default” occurs if: 
  

	 	(1)	The Company defaults in the payment of interest on any Security of any series when it becomes due and payable and the default continues for a period of 30 days (or such other period, which may be no period as is
specified in the Supplemental Indenture relating to the series); 


  
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	 	(2)	The Company defaults in the payment of the principal of, or premium, if any, on any Security of any series as and when it becomes due and payable at its stated maturity or upon redemption, acceleration or otherwise and,
if provided in the Supplemental Indenture relating to a series, the default continues for a period specified in the Supplemental Indenture; 

  

	 	(3)	The Company fails to comply with any of its other covenants or agreements with regard to Securities of a series or this Indenture (other than a covenant or agreement, a default in whose performance or whose breach is
dealt with specifically elsewhere in this Section) and that failure continues for a period of 90 days after the date of the notice specified below; 

  

	 	(4)	the Company, pursuant to any Bankruptcy Law applicable to the Company: 

 (A)
commences a voluntary case; 
 (B) consents to the entry of an order for relief against it in an involuntary case; 

(C) consents to the appointment of a Custodian of it or for any substantial part of its property; or 

(D) makes a general assignment for the benefit of its creditors; or 

 

	 	(5)	a court of competent jurisdiction enters an order or decree under any applicable Bankruptcy Law: 


(A) for relief in an involuntary case; 

(B) appointing a Custodian of the Company or for any substantial part of its property; or 

(C) ordering its winding up or liquidation; and the order or decree remains unstayed and in effect for 90 days. 

Each of the occurrences described in clauses (1) through (5) will constitute an Event of Default whatever the reason for the occurrence
and whether it is voluntary or involuntary or is effected by operation of law or pursuant to any judgment, decree or order of any court or any order, rule or regulation of any administrative or governmental body. 

The term “Bankruptcy Law” means Title 11 of the United States Code or any similar United States Federal or State law for the
relief of debtors. The term “Custodian” means any receiver, trustee, assignee, liquidator, custodian or similar official under any Bankruptcy Law. 

  
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 A Default under clause (3) of this Section is not an Event of Default until the Trustee
notifies the Company, or the Holders of at least 25% in principal amount of the then outstanding Securities of a series with regard to which the Company has failed to comply with a covenant or agreement notify the Company and the Trustee, of the
Default and the Company does not cure the Default within 90 days after the giving of the notice. The notice must specify the Default, demand that it be remedied and state that the notice is a “Notice of Default.” 

A Default under clause (1), (2) or (3) with regard to Securities of a series will not constitute a Default with regard to Securities of
any other series except to the extent, if any, provided in the Supplemental Indenture relating to the other series. 
 SECTION 6.02.
Acceleration. If an Event of Default as to the Securities of a series occurs and is continuing, unless the principal of all of the Securities of the series has already become due and payable, the Trustee by notice to the Company, or the
Holders of at least 25% in aggregate principal amount of the Securities of the series then outstanding by notice to the Company and the Trustee, may declare the principal of and accrued interest, if any, on all the Securities of the series to be due
and payable. Upon such a declaration, that principal and interest will be due and payable immediately. If an Event of Default specified in Section 6.01(4) or (5) occurs, the principal of, premium, if any, and accrued interest, if any, on
all the Securities will automatically become and be immediately due and payable without any declaration or other act on the part of the Trustee or any Securityholders. The Holders of a majority in principal amount of the Securities of a series then
outstanding, on behalf of the Holders of all the Securities of the series, by notice to the Trustee may rescind an acceleration and its consequences if all existing Events of Default have been cured or waived except nonpayment of principal, premium,
if any, or interest, if any, that has become due solely because of acceleration, and if the rescission would not conflict with any judgment or decree. No such rescission will affect any subsequent default or impair any consequent right. 

SECTION 6.03. Other Remedies. If an Event of Default as to a series occurs and is continuing, the Trustee may pursue any available
remedy to collect the payment of principal of, premium, if any, and interest, if any, on the Securities of the series or to enforce the performance of any provision under this Indenture or any applicable Supplemental Indenture. 

The Trustee may maintain a proceeding even if it does not possess any of the Securities or does not produce any of them in the proceeding. A
delay or omission by the Trustee or any Securityholder in exercising any right or remedy accruing upon an Event of Default will not impair the right or remedy or constitute a waiver of or acquiescence in the Event of Default. No remedy is exclusive
of any other remedy. All available remedies are cumulative. 
 SECTION 6.04. Waiver of Existing Defaults. The Holders of a majority
in aggregate principal amount of the Securities of a series then outstanding, on behalf of the Holders of all the Securities of that series, by notice to the Trustee may consent to the waiver of any past Default with regard to Securities of the
series and its consequences except (i) a default in the payment of interest or premium, if any, on, or the principal of, Securities of the series, or (ii) a default in respect of a covenant or a provision that under Section 9.02
cannot be modified or amended without the consent of the Holders of all Securities of the series then outstanding. The defaults described in clauses (i) and (ii) in the previous sentence may be waived with the consent of the Holders of all
Securities of the series then outstanding. When a Default or Event of Default is waived, it is deemed cured and not continuing, but no waiver will extend to any subsequent or other Default or impair any consequent right. 

  
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 SECTION 6.05. Control by Majority. The Holders of a majority in principal amount of the
Securities of a series then outstanding may direct the time, method and place of conducting any proceeding for any remedy available to the Trustee with regard to the Securities of that series or of exercising any trust or power conferred on the
Trustee with regard to the Securities of that series. However, the Trustee may refuse to follow any direction that conflicts with law or this Indenture or, subject to Section 7.01, that the Trustee determines is unduly prejudicial to the rights
of other Securityholders or that would involve the Trustee in personal liability provided, however, that the Trustee may take any other action deemed proper by the Trustee that is not inconsistent with such direction. Prior to taking any action as a
result of a direction given under this Section, the Trustee will be entitled to indemnification satisfactory to it in its sole discretion against all losses and expenses caused by taking or not taking that action. 

SECTION 6.06. Payments of Securities on Default; Suit Therefor. The Company covenants that upon the occurrence of an Event of Default
described in Section 6.01(1) or (2), then, upon demand of the Trustee, the Company will pay to the Trustee, for the benefit of the holders of the Securities in all series, the whole amount that will then have become due and payable on all such
Securities for principal, premium, if any, and interest, with interest on the overdue principal and premium, if any, and (to the extent that payment of such interest is enforceable under applicable law) on the overdue installments of interest at the
rate borne by the Securities in all series; and, in addition, such further amount as will be sufficient to cover the costs and expenses of collection, including a reasonable compensation to the Trustee, its agents, attorneys and counsel, and any
expenses or liabilities incurred by the Trustee hereunder other than through its gross negligence or willful misconduct. Until such demand by the Trustee, the Company may pay the principal of and premium, if any, and interest on the Securities of
all series to the registered Holders, whether or not the Securities in that series are overdue. 
 SECTION 6.07. Limitation on Suits.
A Securityholder may not pursue any remedy with respect to this Indenture, unless: 
  

	 	(1)	the Holder gives to the Trustee written notice stating that an Event of Default as to a series is continuing; 

  

	 	(2)	the Holders of at least 25% in principal amount of the Securities of the series then outstanding make a written request to the Trustee to institute such action, suit or proceeding in its own name as Trustee hereunder;


  

	 	(3)	such Holder or Holders offer to the Trustee security or indemnity reasonably satisfactory to the Trustee against any loss, liability or expense; 


 

	 	(4)	the Trustee does not comply with the request within 60 days after receipt of the request and the offer of security or indemnity, and the Event of Default has not been waived; and 


 

	 	(5)	the Trustee has received no contrary direction from the Holders of a majority in principal amount of the Securities of the series then outstanding during such 60-day period.



  
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 A Securityholder may not use this Indenture to prejudice the rights of another Holder of the same
series of Securities or to obtain a preference or priority over another Holder of the same series of Securities. 
 SECTION 6.08. Rights
of Holders to Receive Payment and to Demand Conversion. Notwithstanding any other provision of this Indenture, the right of any Holder of a Security of any series to receive payment of principal of, premium, if any, and interest, if any, on the
Security (and interest on overdue principal and interest on overdue installments of interest, if any, as provided in Section 4.01), on or after the respective due dates expressed in the Security or, in the case of redemption, on or after the
redemption date, or in the case of conversion or exchange, to receive the security issuable upon conversion or exchange or to institute suit for the enforcement of any such payment, conversion or exchange on or after the applicable due date,
redemption date or conversion or exchange date, as the case may be, against the Company, will not be impaired or affected without the consent of the Holder. 

SECTION 6.09. Collection Suit by Trustee. If an Event of Default in payment of principal, premium, if any, or interest, if any,
specified in clause (1) or (2) of Section 6.01 occurs and is continuing, the Trustee may recover judgment in its own name and as trustee of an express trust against the Company for the whole amount of principal, premium, if any, and
interest remaining unpaid (together with interest on that unpaid interest to the extent lawful) and the amounts provided for in Section 7.07. 

SECTION 6.10. Trustee May File Proofs of Claim. The Trustee may file such proofs of claim and other papers or documents as may be
necessary or advisable in order to have the claims of the Trustee and the Holders of the Securities of any or all series allowed in any judicial proceedings relative to the Company, its creditors or its property and, unless prohibited by law or
applicable regulations, may vote on behalf of the Holders in any election of a trustee in bankruptcy or other person performing similar functions, and any Custodian in any such judicial proceeding is hereby authorized by each Holder to make payments
to the Trustee and, if the Trustee consents to the making of such payments directly to the Holders, to pay to the Trustee any amount due it for the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and its
counsel, and any other amounts due the Trustee under Section 7.07. 
 SECTION 6.11. Restoration of Positions. If a judicial
proceeding by the Trustee or a Securityholder to enforce any right or remedy under this Indenture or any Supplemental Indenture is dismissed or decided favorably to the Company, except as otherwise provided in the judicial proceeding, the Company,
the Trustee and the Securityholders will be restored to the positions they would have been in if the judicial proceeding had not been instituted. 

SECTION 6.12. Priorities. If the Trustee collects any money pursuant to this Article VI with respect to Securities of a series, subject
to Article XI, or, after an Event of Default set forth in Section 6.01(4) or (5), any money or other property distributable in respect of the Company’s obligations under this Indenture, it will pay out the money or property in the
following order: 

  
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		 	FIRST:	 	to the Trustee (including any predecessor trustee) for amounts due under Section 7.07;
			
		 	SECOND:	 	to Securityholders for amounts due and unpaid on the Securities of the series for principal and interest, ratably, without preference or priority of any kind, according to the amounts due and payable on the Securities of the series
for principal and interest, respectively; and
			
		 	THIRD:	 	to the Company.

 The Trustee may fix a record date and payment date for any payment to Holders of Securities of a series
pursuant to this Section. At least 15 days before the record date, the Company will mail to each Holder of Securities of the series and the Trustee a notice that states the record date, the payment date and the amount to be paid. 

SECTION 6.13. Undertaking for Costs. In any suit for the enforcement of any right or remedy under this Indenture or any Supplemental
Indenture, or in any suit against the Trustee for any action taken or omitted by it as Trustee, a court in its discretion may require the filing by any party litigant in the suit of an undertaking to pay the costs of the suit, and the court in its
discretion may assess reasonable costs, including reasonable attorneys’ fees and expenses (whether incurred before trial, at trial or on appeal or in any bankruptcy, arbitration or other administrative proceeding), against any party litigant in
the suit, having due regard to the merits and good faith of the claims or defenses made by the party litigant. This Section 6.13 does not apply to a suit by the Trustee, a suit by a Holder pursuant to Section 6.07, or a suit by Holders of
in aggregate more than 10% in principal amount of the Securities of a series then outstanding, or to any suit instituted by any Holder for the enforcement of the payment of the principal of, premium, if any, or interest on any Security held by that
Holder on or after the due date provided in the Security or to any suit for the enforcement of the right to convert or exchange any Security in accordance with the provisions of a Supplemental Indenture applicable to that Security. 

SECTION 6.14. Stay, Extension or Usury Laws. The Company agrees (to the extent that it may lawfully do so) that it will not at any time
insist upon, or plead, or in any manner whatsoever claim, and will resist any and all efforts to be compelled to take the benefit or advantage of, any stay or extension law or any usury or other law, wherever enacted, now or at any subsequent time
in force, which would prohibit or forgive the Company from paying all or any portion of the principal of, premium, if any, and/or interest on any of the Securities as contemplated in this Indenture or a Supplemental Indenture, or which may affect
the covenants or performance of this Indenture, and the Company (to the extent that it may lawfully do so) hereby expressly waives all benefit or advantage of any such law and agrees that it will not hinder, delay or impede the execution of any
power granted to the Trustee in this Indenture or any Supplemental Indenture, but (to the extent that it may lawfully do so) will suffer and permit the execution of any such power as though no such law had been enacted. 

  
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 SECTION 6.15. Liability of Stockholders, Officers, Directors and Incorporators. No
stockholder, officer, director or incorporator, as such, past, present or future, of the Company, or any of its successor corporations, will have any personal liability in respect of the Company’s obligations under this Indenture or any
Securities by reason of his or its status as such stockholder, officer, director or incorporator; provided, however, that nothing in this Indenture or in the Securities will prevent recourse to and enforcement of the liability of any stockholder or
subscriber to Capital Stock which have not been fully paid up. 
 ARTICLE VII 

TRUSTEE 
 SECTION 7.01. Duties
of Trustee. 
 (a) The Trustee, prior to the occurrence of an Event of Default and after the curing or waiver of all Events of Default
that may have occurred, undertakes to perform such duties and only such duties as are specifically set forth in this Indenture. In the event an Event of Default has occurred and is continuing, the Trustee shall exercise such of the rights and powers
vested in it by this Indenture, and use the same degree of care and skill in its exercise, as a prudent person would exercise or use under the circumstances in the conduct of such person’s own affairs; provided that if an Event of Default
occurs and is continuing, the Trustee will be under no obligation to exercise any of the rights or powers under this Indenture at the request or direction of any of the Holders unless such Holders have offered to the Trustee indemnity or security
satisfactory to it against any loss, liability or expense that might be incurred by it in compliance with such request or direction. 
 No
provision of this Indenture shall be construed to relieve the Trustee from liability for its own grossly negligent action, its own grossly negligent failure to act or its own willful misconduct, except that: 

(b) prior to the occurrence of an Event of Default and after the curing or waiving of all Events of Default that may have occurred: 

(i) the duties and obligations of the Trustee shall be determined solely by the express provisions of this Indenture, and the
Trustee shall not be liable except for the performance of such duties and obligations as are specifically set forth in this Indenture and no implied covenants or obligations shall be read into this Indenture against the Trustee; and 

(ii) in the absence of bad faith, willful misconduct or gross negligence on the part of the Trustee, the Trustee may
conclusively rely, as to the truth of the statements and the correctness of the opinions expressed therein, upon any certificates or opinions furnished to the Trustee and conforming to the requirements of this Indenture; but, in the case of any such
certificates or opinions that by any provisions hereof are specifically required to be furnished to the Trustee, the Trustee shall be under a duty to examine the same to determine whether or not they conform to the requirements of this Indenture
(but need not confirm or investigate the accuracy of any mathematical calculations or other facts stated therein). 

  
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 (c) the Trustee shall not be liable for any error of judgment made in good faith by a Trust
Officer, unless it shall be proved that the Trustee was negligent in ascertaining the pertinent facts; 
 (d) the Trustee shall not be liable
with respect to any action taken or omitted to be taken by it in good faith in accordance with the written direction of the Holders of not less than a majority (or in the case of Section 6.02, not less than 25%) of the aggregate principal
amount of the series of Securities then outstanding relating to the time, method and place of conducting any proceeding for any remedy available to the Trustee, or exercising any trust or power conferred upon the Trustee, under this Indenture; 

(e) Every provision of this Indenture relating to the conduct or affecting the liability of or affording protection to the Trustee is subject
to the provisions of this Section 7.01 and to the provisions of the TIA; 
 (f) the Trustee shall not be liable in respect of any
payment (as to the correctness of amount, entitlement to receive or any other matters relating to payment) or notice effected by the Company or any Paying Agent or any records maintained by any Registrar with respect to the Securities; 

(g) if any party fails to deliver a notice relating to an event the fact of which, pursuant to this Indenture, requires notice to be sent to
the Trustee, the Trustee may conclusively rely on its failure to receive such notice as reason to act as if no such event occurred, unless a Trust Officer had actual knowledge of such event; 

(h) in the absence of written investment direction from the Company, all cash received by the Trustee shall be placed in a non-interest bearing trust account, and in no event shall the Trustee be liable for the selection of investments or for investment losses incurred thereon or for losses incurred as a result of the liquidation of any
such investment prior to its maturity date or the failure of the party directing such investments prior to its maturity date or the failure of the party directing such investment to provide timely written investment direction, and the Trustee shall
have no obligation to invest or reinvest any amounts held hereunder in the absence of such written investment direction from the Company; and 

(i) in the event that the Trustee is also acting as Custodian, Registrar, Paying Agent, or transfer agent hereunder, the rights and protections
afforded to the Trustee pursuant to this Article VII shall also be afforded to such Custodian, Note Registrar, Paying Agent, or transfer agent. 

None of the provisions contained in this Indenture shall require the Trustee to expend or risk its own funds or otherwise incur personal
financial liability in the performance of any of its duties or in the exercise of any of its rights or powers. 
 SECTION 7.02. Rights of
Trustee. Except as otherwise provided in Section 7.01: 
 (a) The Trustee may conclusively rely and shall be fully protected in
acting upon any resolution, certificate, statement, instrument, opinion, report, notice, request, consent, order, bond, note, coupon or other paper or document believed by it in good faith to be genuine and to have been signed or presented by the
proper party or parties. 

  
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 (b) Before the Trustee acts or refrains from acting, it may require an Officer’s Certificate
which conforms to Section 13.05. The Trustee will not be liable for any action it takes or omits to take in good faith in reliance on such an Officer’s Certificate. 

(c) The Trustee may execute any of the trusts or powers hereunder or perform any duties hereunder either directly or by or through agents or
attorneys and the Trustee shall not be responsible for any misconduct or negligence on the part of any agent or attorney appointed with due care by it hereunder. 

(d) The Trustee will not be liable for any action it takes, suffers or omits to take in good faith which it believes to be authorized or within
its rights or powers, except conduct which constitutes willful misconduct or gross negligence. 
 (e) The Trustee may consult with counsel of
its selection and any advice of such counsel shall be full and complete authorization and protection in respect of any action taken or omitted by it hereunder in good faith and in accordance with such advice or opinion of counsel. 

(f) The Trustee shall not be bound to make any investigation into the facts or matters stated in any resolution, certificate, statement,
instrument, opinion, report, notice, request, direction, consent, order, bond, debenture or other paper or document, but the Trustee, in its discretion, may make such further inquiry or investigation into such facts or matters as it may see fit,
and, if the Trustee shall determine to make such further inquiry or investigation, it shall be entitled to examine the books, records and premises of the Company, personally or by agent or attorney at the expense of the Company for any reasonable
expenses incurred and shall incur no liability of any kind by reason of such inquiry or investigation. 
 (g) Any request or direction of the
Company mentioned herein shall be sufficiently evidenced by a Company Order and any resolution of the Board of Directors may be sufficiently evidenced by a Board Resolution. 

(h) Whenever in the administration of this Indenture the Trustee shall deem it desirable that a matter be proved or established prior to
taking, suffering or omitting any action hereunder, the Trustee (unless other evidence be herein specifically prescribed) may, in the absence of bad faith on its part, conclusively rely upon an Officer’s Certificate. 

(i) The Trustee shall be under no obligation to exercise any of the rights or powers vested in it by this Indenture at the request or direction
of any of the Holders pursuant to this Indenture, unless such Holders shall have offered to the Trustee security or indemnity satisfactory to the Trustee against the costs, expenses and liabilities which might be incurred by it in compliance with
such request or direction. In no event shall the Trustee be required to risk or expend its own funds in the performance of its obligations under this Indenture. 

(j) In no event shall the Trustee be responsible or liable for special, indirect, punitive or consequential loss or damage of any kind
whatsoever (including, but not limited to, loss of profit) irrespective of whether the Trustee has been advised of the likelihood of such loss or damage and regardless of the form of action. 

  
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 (k) The Trustee shall not be deemed to have notice of any Default or Event of Default except any
Default or Event of Default occurring pursuant to clause (1) or (2) of Section 6.01 if, at the time of the occurrence of such Default or Event of Default, the Trustee is the Paying Agent, unless a Trust Officer of the Trustee has actual
knowledge thereof or unless written notice of any event which is in fact such a default and which shall have been given to a Trust Officer of the Trustee at the Corporate Trust Office of the Trustee. 

(l) The rights, privileges, protections, immunities and benefits given to the Trustee, including, without limitation, its right to be
indemnified, are extended to, and shall be enforceable by, the Trustee in each of its capacities hereunder, and each agent and other Person employed to act hereunder. 

(m) The Trustee may request that the Company deliver a certificate setting forth the names of individuals and/or titles of officers authorized
at such time to take specified actions pursuant to this Indenture, which certificate may be signed by any person authorized to sign an Officer’s Certificate, including any person specified as so authorized in any such certificate previously
delivered and not superseded. 
 SECTION 7.03. Individual Rights of Trustee. The Trustee in its individual or any other capacity may
become the owner or pledgee of Securities and may otherwise deal with the Company or any of its affiliates with the same rights it would have if it were not Trustee. Any Paying Agent, Registrar, co-registrar
or co-paying agent may do the same with like rights. However, the Trustee must comply with Sections 7.10 and 7.11. 

SECTION 7.04. Trustee’s Disclaimer. The Trustee (i) is not responsible for and makes no representation as to
the validity, sufficiency or adequacy of this Indenture or any Securities, (ii) will not be responsible for and will not make any representation as to the validity, sufficiency or adequacy of any Supplemental Indenture, (iii) will not be
accountable for the Company’s use of the proceeds from the Securities of any series, and (iv) will not be responsible for any recital or statement of the Company in this Indenture any Supplemental Indenture or any Securities, other than
the Trustee’s certificate of authentication, or in any prospectus used in the sale of any of the Securities, other than statements, if any, provided in writing or approved by the Trustee for use in such a prospectus. The Trustee shall not be
responsible to make any calculation with respect to any matter under this Indenture. 
 SECTION 7.05. Notice of Defaults. The Trustee
will give to the Holders of the Securities of a series notice of any Default with regard to the Securities of that series known to the Trustee (upon receipt in writing by a Trust Officer), within 90 days after it occurs; provided, that, except in
the case of a Default in the payment of the principal of, or premium, if any, or interest on any Security, the Trustee will be protected in withholding notice of the Default if and so long as a committee of its Trust Officers in good faith
determines that the withholding of the notice is in the interests of the Holders of the Securities of the series. 
 SECTION 7.06.
Reports by Trustee. Within 60 days after each May 15 beginning with the May 15 following the date of this Indenture, the Trustee will deliver to the Depositary (in the case of global Securities) or to each Securityholder (in the
case of definitive Securities), at the name and address which appears on the registration books of the Company, and to each 

  
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Securityholder who has, within the two years preceding the mailing, filed that person’s name and address with the Trustee for that purpose and each Securityholder whose name and address have
been furnished to the Trustee pursuant to Section 2.07, a brief report dated as of that May 15 which complies with TIA Section 313(a). The Trustee also will comply with TIA Section 313(b). 

A copy of each report will at the time of its delivery to the Depositary or the Securityholders be filed with each stock exchange on which
Securities are listed and also with the SEC. The Company will promptly notify the Trustee when the Securities of any series are listed on any stock exchange and of any delisting of Securities of any series. 

SECTION 7.07. Compensation and Indemnity. The Company will pay to the Trustee from time to time such compensation for its services as
the Company and the Trustee shall from time to time agree in writing. The Trustee’s compensation will not be limited by any law on compensation of a trustee of an express trust. The Company will reimburse the Trustee upon request for all
reasonable out-of-pocket expenses incurred or made by it, including costs of collection, in addition to the compensation for its services. Those expenses will include
the reasonable compensation and expenses, disbursements and advances of the Trustee’s agents, counsel, accountants and experts. The Company will indemnify the Trustee and its officers, directors, employees and agents against any and all loss,
liability or expense (including reasonable attorneys’ fees and expenses) incurred by it in connection with the administration of the trust created by this Indenture or any Supplemental Indenture and the performance of its duties under this
Indenture or any Supplemental Indenture, including the costs and expenses of defending itself against any claim (whether asserted by the Company, or any Holder or any other Person) or liability in connection with the exercise or performance of any
of its powers or duties hereunder, or in connection with enforcing the provisions of this Section. The Trustee will notify the Company promptly of any claim for which it may seek indemnity. Failure by the Trustee to so notify the Company will not
relieve the Company of its obligations under this Section. The Company will defend the claim and the Trustee may have separate counsel and the Company will pay the fees and expenses of such counsel. The Company need not pay for any settlement made
without its consent. The Company need not reimburse any expense or indemnify against any loss, expense or liability incurred by the Trustee to the extent it is due to the Trustee’s own willful misconduct or gross negligence. 

To secure the Company’s obligation to make payments to the Trustee under this Section 7.07, the Trustee will have a lien prior to
the Securities on all money or property held or collected by the Trustee, other than money or property held in trust to pay principal or interest on particular Securities. Those obligations of the Company will survive the satisfaction and discharge
of this Indenture, the termination for any reason of this Indenture and the resignation or removal of the Trustee. 
 When the Trustee
incurs expenses or renders services after an Event of Default specified in clause (4) or (5) of Section 6.01 occurs, the expenses (including the reasonable charges and expenses of its counsel) and the compensation for the services of the
Trustee are intended to constitute expenses of administration under any Bankruptcy Law. 

  
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 For purposes of this Section 7.07, “Trustee” will include any predecessor
Trustee, but the willful misconduct, negligence or bad faith of any Trustee will not affect the rights of any other Trustee under this Section 7.07. 

SECTION 7.08. Replacement of Trustee. The Trustee may resign at any time by giving written notice of such resignation to the Company.
The Holders of a majority in aggregate principal amount of the Securities of all series then outstanding may remove the Trustee by so notifying the Trustee and the Company and may appoint a successor Trustee. The Company may remove the Trustee if:

  

	 	(1)	the Trustee fails to comply with Section 7.10; 

  

	 	(2)	the Trustee is adjudged bankrupt or insolvent or an order for relief is entered with respect to the Trustee under any Bankruptcy Law; 


 

	 	(3)	a receiver or other public officer takes charge of the Trustee or its property; or 

  

	 	(4)	the Trustee becomes incapable of acting. 

 If the Trustee resigns or is removed or if a vacancy
exists in the office of Trustee for any reason, the Company will promptly appoint a successor Trustee. Within one year after the successor Trustee takes office, the Holders of a majority in aggregate principal amount of Securities of all series then
outstanding may appoint a successor Trustee to replace the successor Trustee appointed by the Company. 
 No removal or appointment of a
Trustee will be valid if that removal or appointment would conflict with any law applicable to the Company. 
 A successor Trustee will
deliver a written acceptance of its appointment to the retiring Trustee and to the Company. Immediately after that, the retiring Trustee will, provided all sums owing to the retiring Trustee hereunder have been paid and subject to the lien provided
for in Section 7.07, transfer all property held by it as a Trustee to the successor Trustee, the resignation or removal of the retiring Trustee will become effective, and the successor Trustee will have all the rights, powers and duties of the
Trustee under this Indenture and all Supplemental Indentures. A successor Trustee will mail notice of its succession to each Securityholder. 

If a successor Trustee does not take office within 30 days after the retiring Trustee resigns or is removed, the retiring Trustee, at the
Company’s expense, the Company or the Holders of a majority in aggregate principal amount of Securities of all series then outstanding may petition any court of competent jurisdiction for the appointment of a successor Trustee. 

If the Trustee fails to comply with Section 7.10, any Securityholder may petition any court of competent jurisdiction for the removal of
the Trustee and the appointment of a successor Trustee. 
 Notwithstanding the replacement of the Trustee pursuant to this Section, the
Company’s obligations under Section 7.07 will continue for the benefit of the retiring Trustee. 

  
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 SECTION 7.09. Successor Trustee by Merger, etc. Any corporation or other entity into which
the Trustee may be merged or converted or with which it may be consolidated, or any corporation or other entity resulting from any merger, conversion or consolidation to which the Trustee shall be a party, or any corporation or other entity
succeeding to all or substantially all of the corporate trust business of the Trustee (including the administration of this Indenture), shall be the successor to the Trustee hereunder without the execution or filing of any paper or any further act
on the part of any of the parties hereto; provided that in the case of any corporation or other entity succeeding to all or substantially all of the corporate trust business of the Trustee such corporation or other entity shall be eligible under the
provisions of Section 7.10. 
 If at the time a successor by merger, conversion or consolidation to the Trustee succeeds to the trusts
created by this Indenture any of the Securities have been authenticated but not delivered, the successor to the Trustee may adopt the certificate of authentication of the predecessor Trustee, and deliver the Securities which were authenticated by
the predecessor Trustee; and if at that time any of the Securities have not been authenticated, the successor to the Trustee may authenticate those Securities either in the name of the predecessor or in its own name as the successor to the Trustee;
and in either case the certificates of authentication will have the full force provided in this Indenture for certificates of authentication. 

SECTION 7.10. Eligibility; Disqualification. The Trustee will at all times satisfy the requirements of TIA Section 310(a). The
Trustee will at all times have a combined capital and surplus of at least $50,000,000 as set forth in its most recently published annual report of condition, which will be deemed for this paragraph to be its combined capital and surplus. The Trustee
will comply with TIA Section 310(b), including the optional provision permitted by the second sentence of TIA Section 310(b)(9); provided, however, that there shall be excluded from the operation of TIA Section 310(b)(1) any indenture
or indentures under which other securities or certificates of interest or participation in other securities of the Company are outstanding if the requirements for such exclusion set forth in TIA Section 310(b)(1) are met, other than the fact
that such indentures are not described herein. 
 SECTION 7.11. Preferential Collection of Claims. The Trustee will comply with TIA
Section 311(a), excluding any creditor relationship listed in TIA Section 311(b). A Trustee who has resigned or been removed will be subject to TIA Section 311(a) to the extent indicated. 

ARTICLE VIII 
 DISCHARGE OF
INDENTURE 
 SECTION 8.01. Termination of the Company’s Obligations. When (i) the Company delivers to the
Trustee all outstanding Securities of all series (other than Securities replaced pursuant to Section 2.09) for cancellation or (ii) all outstanding Securities of all series have become due and payable, or are due and payable within one
year or are to be called for redemption within one year, under arrangements satisfactory to the Trustee for giving the notice of redemption, and the Company irrevocably deposits in trust with the Trustee (subject to Article XI) money or U.S.
Government Obligations without reinvestment sufficient to pay the principal, premium, if any, and interest, if any, on the Securities of all series to maturity or redemption, as the case may be, and if, in the case of either (i) or (ii) above
the Company also pays or causes to be paid all other sums payable by the Company under this Indenture, then this Indenture will cease to be of further effect. 

  
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 Notwithstanding the foregoing, the Company’s obligations to pay principal, premium, if any,
and interest, if any, on the Securities and the Company’s obligations in Sections 2.05, 2.06, 2.07, 2.08, 2.09, 7.07, 7.08 and in Article X will survive until all the Securities of all series are no longer outstanding. Thereafter, the
Company’s obligations in Section 7.07 will survive. 
 Before or after a deposit the Company may make arrangements satisfactory to
the Trustee for the redemption of Securities of a series at a future date to the extent the Securities are redeemable in accordance with Article III and the applicable Supplemental Indenture. 

After a deposit pursuant to this Section 8.01 or after all outstanding Securities of all series have been delivered to the Trustee for
cancellation, the Trustee upon request from the Company, accompanied by an Officer’s Certificate and an Opinion of Counsel which complies with Section 13.05, and at the cost of the Company, will acknowledge in writing the satisfaction and
discharge of the Company’s obligations under the Securities of all series and this Indenture except for those surviving obligations specified above. 

In order to have money available on payment dates to pay principal, premium, if any, or interest, if any, on the Securities of a series, the
U.S. Government Obligations will be payable as to principal, premium, if any, or interest on or before those payment dates in amounts sufficient to provide the necessary money. U.S. Government Obligations used for this purpose may not be callable at
the issuer’s option. 
 SECTION 8.02. Application of Trust Money. Subject to Article XI and Section 8.03, the Trustee will
hold in trust money or U.S. Government Obligations deposited with it pursuant to Section 8.01. It will apply the deposited money and the money from the U.S. Government Obligations through the Paying Agent and in accordance with this Indenture
and any applicable Supplemental Indentures to the payment of principal of, premium, if any, and interest, if any, on the Securities with regard to which the money or U.S. Government Obligations were deposited. 

SECTION 8.03. Repayment to the Company. The Trustee and the Paying Agent will promptly pay to the Company upon request any excess money
or securities held by them at any time. The Trustee and the Paying Agent will pay to the Company upon request any money held by them for the payment of principal, premium or interest that remains unclaimed for two years. After such payment, all
liability of the Trustee and the Paying Agent with respect to that money will cease. 
 SECTION 8.04. Deposited Money and U.S. Government
Obligations to Be Held in Trust. The Company shall pay and indemnify the Trustee against any tax, fee or other charge imposed on or assessed against the U.S. Government Obligations deposited pursuant to Section 8.01 or the principal and
interest received in respect thereof other than any such tax, fee or other charge which by law is for the account of the Holders of outstanding Securities. 

  
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 ARTICLE IX 

AMENDMENTS, SUPPLEMENTS AND WAIVERS 

SECTION 9.01. Without Consent of Holders. The Company and the Trustee may amend or supplement this Indenture or the Securities without
notice to or consent of any Securityholder: 
  

	 	(1)	to cure any ambiguity, omission, defect, error or inconsistency; 

  

	 	(2)	to comply with Article V; 

  

	 	(3)	to establish the form and terms of the Securities of any series as contemplated in Article II of this Indenture; 

  

	 	(4)	to provide for uncertificated Securities in addition to or in place of certificated Securities; or 

  

	 	(5)	to amend, modify or supplement any of the provisions contained herein or in any supplemental indenture, provided that no such amendment or supplement shall materially adversely affect the rights of any Securityholder,
and provided further that any amendment, modification or supplement that conforms this Indenture or any supplemental indenture, as applied to a series of Securities, to the terms described in the prospectus (including any prospectus supplement)
pursuant to which such Securities were initially sold shall be deemed not to adversely affect the rights of Securityholders. 


After an amendment under this Section becomes effective, the Company will mail to the Securityholders a notice briefly describing the
amendment. The failure to give such notice to all Securityholders, or any defect in a notice, will not impair or affect the validity of an amendment under this Section. 

SECTION 9.02. With Consent of Holders. The Company and the Trustee may (i) amend or supplement this Indenture or the Securities
without notice to any Securityholder but with the written consent of the Holders of a majority in aggregate principal amount of the Securities of all series then outstanding or (ii) supplement this Indenture with regard to a series of
Securities, amend or supplement a Supplemental Indenture relating to a series of Securities, or amend the Securities of a series, without notice to any Securityholder but with the written consent of the Holders of a majority in aggregate principal
amount of the Securities of that series then outstanding. The Holders of a majority in principal amount of the Securities of all series then outstanding may waive compliance by the Company with any provision of this Indenture or the Securities
without notice to any Securityholder. The Holders of a majority in principal amount of the Securities of any series then outstanding may waive compliance with any provision of this Indenture, any Supplemental Indenture or the Securities of that
series with regard to the Securities of that series without notice to any Securityholder. However, without the consent of the Holder so affected, no amendment, supplement or waiver, including a waiver pursuant to Section 6.04, may: 

 

	 	(1)	extend the fixed maturity of any Security, reduce the rate or extend the time for payment of interest on any Security, reduce the principal amount of any Security or premium, if any, on any Security; 


  
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	 	(2)	impair or affect the right of a Holder to institute suit for the payment of interest, if any, principal or premium, if any, on the Securities; 


 

	 	(3)	change the currency in which the Securities are payable from that specified in the Securities or in a Supplemental Indenture applicable to the Securities; 


 

	 	(4)	impair the right, if any, to convert the Securities into, or exchange the Securities for, other securities or assets; 

  

	 	(5)	reduce the percentage of Securities required to consent to an amendment, supplement or waiver; 

  

	 	(6)	reduce the amount payable upon the redemption of any Security or change the time at which any Security may or will be redeemed; 

  

	 	(7)	modify the provisions of any Supplemental Indenture with respect to subordination of the Securities of a series in a manner adverse to the Securityholders; or 


 

	 	(8)	make any change in Section 6.04 or 6.08 or the fifth sentence of this Section. 

 It will
not be necessary for the consent of the Holders under this Section to approve the particular form of any proposed amendment, supplement or waiver, but it will be sufficient if the consent approves the substance of the amendment, supplement or
waiver. 
 The Company may, but shall not be obligated to, fix a record date for the purpose of determining the Persons entitled to consent
to any indenture supplemental hereto. If a record date is fixed, the Holders on such record date, or their duly designated proxies, and only such Persons, shall be entitled to consent to such supplemental indenture, whether or not such Holders
remain Holders after such record date; provided, that unless such consent shall have become effective by virtue of the requisite percentage having been obtained prior to the date which is 90 days after such record date, any such consent previously
given shall automatically and without further action by any Holder be cancelled and of no further effect. 
 After an amendment under this
Section becomes effective, the Company will mail to the Securityholders a notice briefly describing the amendment. The failure to give such notice to all Securityholders, or any defect in a notice, will not impair or affect the validity of an
amendment under this Section. 
 SECTION 9.03. Compliance with Trust Indenture Act. Every amendment or supplement to this Indenture,
any Supplemental Indenture or the Securities will comply with the TIA as then in effect. 
 SECTION 9.04. Revocation and Effect of
Consents. A consent to an amendment, supplement or waiver by a Holder of a Security will bind the Holder and every subsequent Holder of a Security or portion of a Security that evidences the same debt as the consenting Holder’s Security,
even if notation of the consent is not made on any Security. However, any such Holder or subsequent Holder may revoke the consent as to the Holder’s Security or portion of a Security. For a revocation to be effective, the Trustee must receive
notice of the revocation before the date the amendment, supplement or waiver becomes effective. After an amendment, supplement or waiver becomes effective in accordance with its terms, it will bind every Holder of every Security of every series to
which it applies. 

  
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 SECTION 9.05. Notation on or Exchange of Securities. If an amendment changes the terms of
a series of Securities, the Trustee may require the Holder of a Security of the series to deliver the Holder’s Security to the Trustee, who will place an appropriate notation about the amendment, supplement or waiver on the Security and will
return it to the Holder. Alternatively, the Company may, in exchange for the Security, issue, and the Trustee (or an authenticating agent duly appointed by the Trustee pursuant to Section 13.15) will authenticate, a new Security that reflects
the amendment, supplement or waiver. 
 SECTION 9.06. Trustee to Sign Amendments, etc. In executing, or accepting the additional
trusts created by, any supplemental indenture permitted by Article II or this Article IX or the modification thereby of the trusts created by this Indenture, the Trustee shall receive, and shall be fully protected in relying upon, an Opinion of
Counsel and an Officer’s Certificate stating that the execution of such supplemental indenture is authorized or permitted by this Indenture. The Trustee will sign any amendment, supplement or waiver authorized pursuant to Article II or this
Article IX if the amendment, supplement or waiver does not adversely affect the rights, duties, liabilities or immunities of the Trustee. If it does adversely affect those rights, duties, liabilities or immunities, the Trustee may but need not sign
it. The Company may not sign an amendment or supplement until the amendment or supplement is approved by an appropriate Board Resolution. 

ARTICLE X 
 CONVERSION OR EXCHANGE
OF SECURITIES 
 SECTION 10.01. Provisions Relating to Conversion or Exchange of Securities. Any rights which Holders of Securities
of a series will have to convert those Securities into other securities of the Company or to exchange those Securities for securities of other Persons or other assets, including but not limited to the terms of the conversion or exchange and the
circumstances, if any, under which those terms will be adjusted to prevent dilution or otherwise, will be set forth in a Supplemental Indenture relating to the series of Securities. In the absence of provisions in a Supplemental Indenture relating
to a series of Securities setting forth rights to convert or exchange the Securities of that series into or for other securities or assets, Holders of the Securities of that series will not have any such rights. 

ARTICLE XI 
 SINKING OR PURCHASE
FUNDS 
 SECTION 11.01. Provisions Relating to Sinking or Purchase Funds. Any requirements that the Company make, or rights of the
Company to make at its option, payments prior to maturity of the Securities of a series which will be used as a fund with which to redeem or to purchase Securities of that series, including but not limited to provisions regarding the amount of the
payments, when the Company will be required, or will have the option, to make the payments and when the payments will be applied, will be set forth in a Supplemental Indenture relating to 

  
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the series of Securities. In the absence of provisions in a Supplemental Indenture relating to a series of Securities setting forth requirements that the Company make, or rights of the Company to
make at its option, payments to be used as a fund with which to redeem or purchase Securities of the series, the Company will not be subject to any such requirements and will not have any such rights. However, unless otherwise specifically provided
in a Supplemental Indenture relating to a series of Securities, the Company will at all times have the right to purchase Securities from Holders in market transactions or otherwise. 

ARTICLE XII 
 CONCERNING THE
HOLDERS 
 SECTION 12.01. Action by Holders. Whenever in this Indenture it is provided that the Holders of a specified percentage of
the aggregate principal amount of the Securities may take any action (including the making of any demand or request, the giving of any notice, consent or waiver or the taking of any other action), the fact that at the time of taking any such action
the Holders of such specified percentage have joined therein may be evidenced (a) by any instrument or any number of instruments of similar tenor executed by Holders in person or by agent or proxy appointed in writing, or (b) by the record
of the Holders voting in favor thereof at any meeting of Holders duly called and held or (c) by a combination of such instrument or instruments and any such record of such a meeting of Holders. Whenever the Company or the Trustee solicits the
taking of any action by the Holders, the Company or the Trustee may fix, but shall not be required to, in advance of such solicitation, a date as the record date for determining Holders entitled to take such action. The record date if one is
selected shall be not more than 15 days prior to the date of commencement of solicitation of such action. 
 SECTION 12.02. Proof of
Execution by Holders. Subject to the provisions of Section 7.01 and Section 7.02, proof of the execution of any instrument by a Holder or its agent or proxy shall be sufficient if made in accordance with such reasonable rules and
regulations as may be prescribed by the Trustee or in such manner as shall be satisfactory to the Trustee. The holding of Securities shall be proved by the Registrar’s books or by a certificate of the Registrar’s books. The record of any
Holders’ meeting shall be proved in the manner determined by the Trustee in accordance with Section 13.07. 
 SECTION 12.03.
Who Are Deemed Absolute Owners. The Company, the Trustee, any authenticating agent, any Paying Agent, any Conversion Agent and any Registrar may deem the Person in whose name a Security shall be registered upon the Registrar’s books to
be, and may treat it as, the absolute owner of such Security (whether or not such Security shall be overdue and notwithstanding any notation of ownership or other writing thereon made by any Person other than the Company or any Registrar) for the
purpose of receiving payment of or on account of the principal of and accrued and unpaid interest on such Security, for conversion of such Security and for all other purposes under this Indenture; and neither the Company nor the Trustee nor any
Paying Agent nor any Conversion Agent nor any Registrar shall be affected by any notice to the contrary. The sole registered holder of a Security in global form (a “Global Security”) shall be the Depositary or its nominee. All such
payments or deliveries so made to any Holder for the time being, or upon its order, shall be valid, and, to the extent of the sums or shares of Common Stock so paid or delivered, effectual to satisfy and discharge the liability for monies payable or
shares 

  
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deliverable upon any such Security. Notwithstanding anything to the contrary in this Indenture or the Securities, following an Event of Default, any owner of a beneficial interest in a Global
Security may directly enforce against the Company, without the consent, solicitation, proxy, authorization or any other action of the Depositary or any other Person, such owner’s right to exchange such beneficial interest for a Security in
certificated form in accordance with the provisions of this Indenture. 
 SECTION 12.04. Revocation of Consents; Future Holders
Bound. At any time prior to (but not after) the evidencing to the Trustee, as provided in Section 12.01, of the taking of any action by the Holders of the percentage of the aggregate principal amount of the Securities specified in this
Indenture in connection with such action, any Holder that is shown by the evidence to be included in the Securities the Holders of which have consented to such action may, by filing written notice with the Trustee at its Corporate Trust Office and
upon proof of holding as provided in Section 12.02, revoke such action so far as concerns such Security. Except as aforesaid, any such action taken by the Holder shall be conclusive and binding upon such Holder and upon all future Holders and
owners of such Security and of any Securities issued in exchange or substitution therefor or upon registration of transfer thereof, irrespective of whether any notation in regard thereto is made upon such Security or any Securities issued in
exchange or substitution therefor or upon registration of transfer thereof. 
 ARTICLE XIII 

MISCELLANEOUS 
 SECTION 13.01.
Trust Indenture Act Controls. If any provision of this Indenture or any Supplemental Indenture limits, qualifies or conflicts with the duties imposed by Section 310 through 317 of the TIA, the imposed duties will control. 

SECTION 13.02. Supplemental Indentures Contract. If any provision of a Supplemental Indenture relating to a series of Securities is
inconsistent with any provision of this Indenture, the provision of the Supplemental Indenture will control with regard to the Securities of the series to which it relates. 

SECTION 13.03. Notices. Any notice or communication under or relating to this Indenture or any Supplemental Indenture will be
sufficiently given if made upon, given or furnished to, or filed with the applicable party, in writing and delivered by facsimile transmission, in person or mailed by first-class mail, certified or registered, return receipt requested, addressed as
follows: 
 if to the Company: Clovis Oncology, Inc. 

5500 Flatiron Parkway, Suite 100 

Boulder, Colorado 80301 

Attention: General Counsel 

Facsimile: (303) 245-0361 

  
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 with a copy (which shall not constitute notice and shall not be required to be delivered in
satisfaction of any requirement hereof) to: 
 Willkie Farr & Gallagher LLP 

787 Seventh Avenue 
 New York,
New York 10019 
 Attention: Thomas Mark 

Facsimile: (212) 728-9667 

if to the Trustee: The Bank of New York Mellon Trust Company, N.A. 

400 South Hope Street 
 Mellon
Bank Center 
 Los Angeles, CA 90071 

Attn: Corporate Trust 
 Either
the Company or the Trustee by a notice to the other may designate additional or different addresses for subsequent notices or communications. 

Any notice or communication sent to a Securityholder will be sent to the Securityholder at the Securityholder’s address as it appears on
the registration books of the Registrar and will be sufficiently given to the Securityholder if so sent within the time prescribed. 

Failure to send a notice or communication to a Securityholder or any defect in it will not affect its sufficiency with respect to other
Securityholders. If a notice or communication is mailed in the manner provided above, it is duly given, whether or not the addressee receives it. 

If by reason of the suspension of regular mail service, or by reason of any other cause, it is impossible to send any notice as required by
this Indenture or any Supplemental Indenture, then any method of notification which is approved by the Trustee will constitute a sufficient sending of the notice. 

The Company may set a record date for purposes of determining the identity of Securityholders entitled to vote or consent to any action by
vote or consent authorized or permitted by Sections 6.04 and 6.05. The record date will be the later of 30 days prior to the first solicitation of consents or the date of the most recent list of Holders furnished to the Trustee pursuant to
Section 2.07 prior to the solicitation. 
 The Trustee shall have the right, but shall not be required, to rely upon and comply with
notices, instructions, directions or other communications sent by e-mail, facsimile and other similar unsecured electronic methods by persons believed by the Trustee to be authorized to give instructions and
directions on behalf of the Company. The Trustee shall have no duty or obligation to verify or confirm that the person who sent such instructions or directions is, in fact, a person authorized to give instructions or directions on behalf of the
Company; and the Trustee shall have no liability for any losses, liabilities, costs or expenses incurred or sustained by the Company as a result of such reliance upon or compliance with such notices, instructions, directions or other communications.
The Company agrees to assume all risks arising out of the use of such electronic methods to submit notices, instructions, directions or other communications to the Trustee, 

  
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including without limitation the risk of the Trustee acting on unauthorized instructions, and the risk of interception and misuse by third parties. The Company shall use all reasonable endeavors
to ensure that any such notices, instructions, directions or other communications transmitted to the Trustee pursuant to this Indenture are complete and correct. Any such notices, instructions, directions or other communications shall be
conclusively deemed to be valid instructions from the Company to the Trustee for the purposes of this Indenture. 
 SECTION 13.04.
Communication by Holders with Other Holders. Securityholders may communicate pursuant to TIA Section 312(b) with other Securityholders with respect to their rights under this Indenture or the Securities. Each of the Company, the Trustee,
the Registrar and anyone else will have the protection of TIA Section 312(c). 
 SECTION 13.05. Certificate and Opinion as to
Conditions Precedent. Upon any request or application by the Company to the Trustee to take any action under this Indenture or any Supplemental Indenture, the Company will furnish to the Trustee: 

 

	 	(1)	an Officer’s Certificate stating that, in the opinion of the signer, all conditions precedent, if any, provided for in this Indenture or any Supplemental Indenture relating to the proposed action have been complied
with; 

  

	 	(2)	an Opinion of Counsel stating that, in the opinion of such counsel, all those conditions precedent, if any, provided for in this Indenture or any Supplemental Indenture relating to the proposed action have been complied
with; and 

  

	 	(3)	such other opinions and certificates as may be required by applicable provisions of this Indenture or the Supplemental Indenture. 


Each certificate or opinion with respect to compliance with a condition or covenant provided for in this Indenture or a Supplemental Indenture
will include: 
 (i) a statement that each person signing the certificate or opinion has read such covenant or condition and
the definitions herein relating thereto; 
 (ii) a brief statement as to the nature and scope of the examination or
investigation upon which the statements or opinions contained in the certificate or opinion are based; 
 (iii) a statement
that, in the opinion of the person giving the certificate or opinion, that person has made such examination or investigation as is necessary to enable that person to express an informed opinion as to whether or not the covenant or condition has been
complied with; and 
 (iv) a statement as to whether or not, in the opinion of that person, the condition or covenant has
been complied with. 
 Nothing in this Section 13.05 will be construed as requiring that the Company furnish to the Trustee any
evidence of compliance with the conditions and covenants provided for in this Indenture or any Supplemental Indenture other than the evidence specified in this Section 13.05 except as may be required by any other provision of this Indenture.


  
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 SECTION 13.06. When Treasury Securities Disregarded. In determining whether the Holders of
the required principal amount of Securities have concurred in any direction, waiver or consent, Securities owned by the Company, or anyone under direct or indirect control or under direct or indirect common control with the Company will be
disregarded and deemed not to be outstanding, except that for the purposes of determining whether the Trustee will be protected in relying on any such direction, waiver or consent, only Securities which a Trust Officer of the Trustee actually knows
are so owned will be so disregarded. Securities so owned which have been pledged in good faith will not be disregarded if the pledgee establishes to the satisfaction of the Trustee the pledgee’s right to act with respect to the Securities and
that the pledgee is not the Company or a person directly or indirectly controlling or controlled by, or under common control with, the Company. Nothing in this Section 13.06 will be construed as requiring that the Company furnish to the Trustee
any evidence of compliance with the conditions and covenants provided for in the Indenture other than the evidence specified in this Section 13.06. 

SECTION 13.07. Rules by Trustee, Paying Agent, Registrar. The Trustee may make reasonable rules for action by or at a meeting of
Securityholders. The Paying Agent or Registrar may make reasonable rules for its functions. 
 SECTION 13.08. Legal Holidays. If a
payment date or Maturity Date is not a Business Day, then any action to be taken on such date need not be taken on such date, but may be taken on the next succeeding Business Day with the same force and effect as if taken on such date, and no
interest shall accrue in respect of any payment that would otherwise need to be made on such date on account of the delay. 
 SECTION 13.09.
Governing Law and Submission to Jurisdiction. The laws of the State of New York will govern this Indenture, each Supplemental Indenture and the Securities, and any dispute, case or controversy arising thereunder or relating thereto. The
Company submits to the jurisdiction of the courts of the State of New York sitting in the Borough of Manhattan, The City of New York, and of the United States District Court for the Southern District of New York, in any action or proceeding to
enforce any of its obligations under this Indenture or any Supplemental Indenture or with regard to the Securities, and agrees not to seek a transfer of any such action or proceeding on the basis of inconvenience of the forum or otherwise (but the
Company will not be prevented from removing any such action or proceeding from a state court to the United States District Court for the Southern District of New York). The Company agrees that process in any such action or proceeding may be served
upon it by registered mail or in any other manner permitted by the rules of the court in which the action or proceeding is brought. 

SECTION 13.10. Actions by the Company. Any action or proceeding brought by the Company to enforce any right, assert any claim or obtain
any relief in connection with this Indenture, any Supplemental Indenture or the Securities will be brought by the Company exclusively in the courts of the State of New York sitting in the Borough of Manhattan, The City of New York or in the United
States District Court for the Southern District of New York. 

  
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 SECTION 13.11. No Adverse Interpretation of Other Agreements. Neither this Indenture nor
any Supplemental Indenture may be used to interpret another indenture, loan or debt agreement of the Company or any Subsidiary. No such indenture, loan or debt agreement may be used to interpret this Indenture or any Supplemental Indenture. 

SECTION 13.12. Successors. All agreements of the Company in this Indenture, any Supplemental Indentures and the Securities will bind
its successors. All agreements of the Trustee in this Indenture and any Supplemental Indentures will bind its successors. 
 SECTION 13.13.
Duplicate Originals. The parties may sign any number of copies of this Indenture or any Supplemental Indenture. Each signed copy will be an original, but all of them together will represent the same agreement. The exchange of copies of this
Indenture and of signature pages by facsimile or electronic format (i.e., “pdf” or “tif”) transmission shall constitute effective execution and delivery of this Indenture as to the parties hereto and may be used in lieu of the
original Indenture for all purposes. Signatures of the parties hereto transmitted by facsimile or electronic format (i.e., “pdf” or “tif”) shall be deemed to be their original signatures for all purposes. 

SECTION 13.14. Table of Contents, Headings, etc. The table of contents, cross-reference sheet and headings of the Articles and Sections
of this Indenture have been inserted for convenience of reference only. They are not to be considered a part of this Indenture, and will in no way modify or restrict any of the terms or provisions of this Indenture. 

SECTION 13.15. Authenticating Agent. The Trustee may appoint an authenticating agent that shall be authorized to act on its behalf and
subject to its direction in the authentication and delivery of Securities in connection with the original issuance thereof and transfers and exchanges of Securities hereunder, including under Section 2.04, Section 2.05, Section 2.09,
Section 2.11 and Section 9.05 as fully to all intents and purposes as though the authenticating agent had been expressly authorized by this Indenture and those Sections to authenticate and deliver Securities. For all purposes of this
Indenture, the authentication and delivery of Securities by the authenticating agent shall be deemed to be authentication and delivery of such Securities “by the Trustee” and a certificate of authentication executed on behalf of the
Trustee by an authenticating agent shall be deemed to satisfy any requirement hereunder or in the Securities for the Trustee’s certificate of authentication. Such authenticating agent shall at all times be a Person eligible to serve as trustee
hereunder pursuant to Section 7.10. 
 Any corporation or other entity into which any authenticating agent may be merged or converted
or with which it may be consolidated, or any corporation or other entity resulting from any merger, consolidation or conversion to which any authenticating agent shall be a party, or any corporation or other entity succeeding to the corporate trust
business of any authenticating agent, shall be the successor of the authenticating agent hereunder, if such successor corporation or other entity is otherwise eligible under this Section 13.15, without the execution or filing of any paper or
any further act on the part of the parties hereto or the authenticating agent or such successor corporation or other entity. 

  
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 Any authenticating agent may at any time resign by giving written notice of resignation to the
Trustee and to the Company. The Trustee may at any time terminate the agency of any authenticating agent by giving written notice of termination to such authenticating agent and to the Company. Upon receiving such a notice of resignation or upon
such a termination, or in case at any time any authenticating agent shall cease to be eligible under this Section, the Trustee may appoint a successor authenticating agent (which may be the Trustee), shall give written notice of such appointment to
the Company and shall mail or transmit notice of such appointment to all Holders as the names and addresses of such Holders appear on the Note Register. 

The Company agrees to pay to the authenticating agent from time to time reasonable compensation for its services although the Company may
terminate the authenticating agent, if it determines such agent’s fees to be unreasonable. 
 The provisions of Section 2.08,
Section 7.02, Section 7.03 and Section 7.04 and this Section 13.15 shall be applicable to any authenticating agent. 

If an authenticating agent is appointed pursuant to this Section 13.15, the Securities may have endorsed thereon, in addition to the
Trustee’s certificate of authentication, an alternative certificate of authentication in the following form: 

                       
     , as Authenticating Agent, certifies that this is one of the Securities described in the within-named Indenture. 
  

	
	By:                                     
                            
	Authorized Officer


 SECTION 13.16. Execution in Counterparts. This Indenture may be executed in any number of
counterparts, each of which shall be an original, but such counterparts shall together constitute but one and the same instrument. The exchange of copies of this Indenture and of signature pages by facsimile or PDF transmission shall constitute
effective execution and delivery of this Indenture as to the parties hereto and may be used in lieu of the original Indenture for all purposes. Signatures of the parties hereto transmitted by facsimile or PDF shall be deemed to be their original
signatures for all purposes. 
 SECTION 13.17. Severability. In the event any provision of this Indenture or in the Securities shall
be invalid, illegal or unenforceable, then (to the extent permitted by law) the validity, legality or enforceability of the remaining provisions shall not in any way be affected or impaired. 

SECTION 13.18. Waiver of Jury Trial. EACH OF THE COMPANY, THE HOLDERS AND THE TRUSTEE HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT
PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THIS INDENTURE, THE SECURITIES OR THE TRANSACTION CONTEMPLATED HEREBY. 

SECTION 13.19. Force Majeure. In no event shall the Trustee be responsible or liable for any failure or delay in the performance of its
obligations hereunder arising out of or caused by, directly or indirectly, forces beyond its control, including, without limitation, strikes, work stoppages, accidents, acts of war or terrorism, civil or military disturbances, nuclear or natural
catastrophes or acts of God, and interruptions, loss or malfunctions of utilities, communications or computer (software and hardware) services; it being understood that the Trustee shall use reasonable best efforts which are consistent with accepted
practices in the banking industry to resume performance as soon as practicable under the circumstances. 

  
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 SECTION 13.20. FATCA. In order to comply with Sections 1471 through 1474 of the U.S.
Internal Revenue Code and the rules and regulations thereunder (as in effect from time to time, collectively, the “Applicable Law”), a foreign financial institution, issuer, collateral agent, paying agent, holder or other
institution is or has agreed to be subject to related to this Indenture, the Company and the Securityholders agree (i) to provide to the Trustee upon its request information in the Company’s possession about holders or other applicable
parties and/or transactions (including any modification to the terms of such transactions) so the Trustee can determine whether it has tax related obligations under the Applicable Law and (ii) that the Trustee shall be entitled to make any
withholding or deduction from payments under this Indenture to the extent necessary to comply with the Applicable Law for which the Trustee shall not have any liability for its withholding or deduction from payment under this Indenture to the extent
necessary to comply with Applicable Law. The terms of this section shall survive the termination of this Indenture. 
 IN WITNESS WHEREOF,
the parties to this Indenture have caused it to be duly executed as of the day and year first above written. 
  

					
	CLOVIS ONCOLOGY, INC.
		
	By:	 	 /s/ Daniel W. Muehl

		 	Name:	 	Daniel W. Muehl
		 	Title:	 	Senior Vice President of Finance, Principal Financial Officer and Principal Accounting Officer
	
	The Bank of New York Mellon Trust Company, N.A., as Trustee
		
	By:	 	 /s/ Karen Yu

		 	Name:	 	Karen Yu
		 	Title:	 	Vice President



  
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 EXHIBIT A 

(Form of Face of Security) 

[THIS SECURITY IS ISSUED IN GLOBAL FORM AND REGISTERED IN THE NAME OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION
(“DTC”) OR A NOMINEE THEREOF. UNLESS THIS SECURITY IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF DTC, TO THE COMPANY (AS DEFINED BELOW) OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY SECURITY ISSUED IS
REGISTERED IN THE NAME OF CEDE & CO., OR SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS MADE TO CEDE & CO., OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF
DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. 

UNLESS AND UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES IN DEFINITIVE REGISTERED FORM IN ACCORDANCE WITH THE TERMS HEREOF AND OF
THE INDENTURE (AS DEFINED BELOW), THIS SECURITY MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY DTC TO A NOMINEE OF DTC OR BY A NOMINEE OF DTC TO DTC OR ANOTHER NOMINEE OF DTC OR BY DTC OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITORY OR A NOMINEE OF SUCH
SUCCESSOR DEPOSITORY.]* 
  

	*	Insert in Global Security only. 

 CLOVIS ONCOLOGY, INC. 

% [SENIOR/SUBORDINATED] NOTE DUE 
  

	
	  
 CUSIP:

	ISIN:
	Common Code:


 Clovis Oncology, Inc., a Delaware corporation, promises to pay to [Cede & Co.]*
[    ], or registered assigns, the principal sum of Dollars on 
 Interest Payment Dates: and 

Record Dates: and 
 Additional
provisions of this Security are set forth on the reverse hereof. 
  

	 	*	Insert in Global Security only. 


  
 - 1 - 







 IN WITNESS WHEREOF, the Company has caused this Security to be signed manually or by facsimile by
its duly authorized officer. 
  

			
	CLOVIS ONCOLOGY, INC.
		
	By:	 	 
		 	Name:
		 	Title:


 TRUSTEE’S CERTIFICATE OF AUTHENTICATION 

THE BANK OF NEW YORK MELLON TRUST 
 COMPANY, N.A. as Trustee,

 certifies that this is one of the 
 Notes described in the

 within-named Indenture. 
  

			
	By:                                     
                        	  	Date:                                     
                        
	 Authorized Signature
	  	


  
 - 2 - 







 (Form of Reverse of Security) 

CLOVIS ONCOLOGY, INC. 

%[SENIOR/SUBORDINATED] NOTE DUE 

1. Interest. Clovis Oncology, Inc., a Delaware corporation (such corporation, and its successors and assigns under the Indenture
referred to below, being herein called the “Company”), promises to pay interest on the principal amount of this Security at the interest rate per annum shown above. The Company will pay interest semiannually on and of each year.
Interest on the Securities of this series will accrue from the most recent date to which interest has been paid or duly provided for or, if no interest has been paid or duly provided for, from . Interest will be computed [on the basis of a 360-day year consisting of twelve 30-day months] [as set forth in the Officer’s Certificate or supplemental indenture delivered pursuant to the Indenture]. 

2. Method of Payment. The Company will pay interest on the Securities of this series (except defaulted interest) to the persons who are
registered Holders of Securities of this series at the close of business on the record date next preceding the interest payment date even though such Securities are canceled after the record date and on or before the interest payment date. Holders
must surrender Securities to a Paying Agent to collect principal payments. The Company will pay principal and interest in money of the United States that at the time of payment is legal tender for payment of public and private debts. However, the
Company may pay principal and interest by check payable in such money. It may mail an interest check to a Holder’s registered address. 

3. Paying Agent, Registrar. Initially, [ ] (the “Trustee”), will act as Paying Agent and Registrar. The Company may
change any Paying Agent, Registrar or co-registrar without notice. The Company may act as Paying Agent, Registrar or co-registrar. 

4. Indenture. The Company issued the Securities of this series under an Indenture dated as of [     ] (the
“Indenture”) between the Company and the Trustee. The Securities are unsecured general obligations of the Company issued and to be issued in one or more series under the Indenture and may be issued in an unlimited principal amount.
The terms of the Securities include those stated in the Indenture and those made part of the Indenture by reference to the Trust Indenture Act of 1939 (15 U.S. Code Sections 77aaa-77bbbb) (the “TIA”). Capitalized terms used herein
but not defined herein are used as defined in the Indenture. The Securities are subject to all such terms, and Securityholders are referred to the Indenture and the TIA for a statement of such terms. 

5. Redemption. [Set forth redemption provision, if any.] 

6. Denominations; Transfer; Exchange. The Securities of this series are in registered form without coupons in denominations of $1,000
and any integral multiple thereof [or as otherwise set forth in the Security]. The transfer of Securities may be registered and Securities may be exchanged as provided in the Indenture. The Registrar may require a Holder, among other things, to
furnish appropriate endorsements and transfer documents and to pay any taxes and fees required by law or permitted by the Indenture. The Company shall not be required (a) to issue, register the transfer of or exchange any Securities of a series
during a period beginning at the opening of business 15 days before the day of the mailing of a notice of redemption of any such 

  
 - 3 - 







 
Securities selected for redemption under Section 3.03 of the Indenture and ending at the close of business on the day of such mailing or (b) to register the transfer of or exchange any
Security so selected for redemption in whole or in part, except the unredeemed portion of any Security being redeemed in part. 
 7.
Defeasance. Subject to certain conditions and unless otherwise provided in the terms of the Securities of this series, the Company at any time may terminate some or all of its obligations under the Securities and the Indenture if the Company
deposits with the Trustee money for the payment of principal and interest on the Securities to maturity. 
 8. Persons Deemed Owners.
The registered Holder of a Security may be treated as its owner for all purposes, except that interest (other than defaulted interest) will be paid to the person that was the registered Holder on the relevant record date for such payment of
interest. 
 9. Amendments and Waivers. Subject to certain exceptions, (i) the Indenture or the Securities may be amended or
supplemented with the consent of the Holders of a majority in principal amount of the Securities of each series affected; and (ii) any existing default with respect to the Securities of this series may be waived with the consent of the Holders
of a majority in principal amount of the Securities of such series. Without the consent of any Securityholder, the Indenture or the Securities may be amended or supplemented to, among other things, cure any ambiguity, omission, defect, error or
inconsistency, to provide for assumption of Company obligations by a successor to provide for uncertificated Securities in addition to or in place of certificated Securities, to provide for guarantees with respect to, or security for, the
Securities, or to comply with the TIA or to add additional covenants or surrender Company rights. 
 10. Remedies. If an Event of
Default with respect to the Securities of this series occurs and is continuing, the Trustee or Holders of at least 25% in principal amount of the Securities of this series may declare all the Securities of this series to be due and payable
immediately. Securityholders may not enforce the Indenture or the Securities of this series except as provided in the Indenture. The Trustee may require an indemnity before it enforces the Indenture or the Securities. Subject to certain limitations,
Holders of a majority in principal amount of the Securities of a series may direct the Trustee in its exercise of any trust or power with respect to such series. The Trustee may withhold from Securityholders notice of any continuing default (except
a Default in payment of principal or interest) if it determines that withholding notice is in their interests. The Company must furnish an annual compliance certificate to the Trustee. 

11. Subordination. [Set forth subordination provision, if any.] 

12. Trustee Dealings with Company. Subject to the provisions of the TIA, the Trustee under the Indenture, in its individual or any
other capacity, may make loans to, accept deposits from, and perform services for the Company or its affiliates, and may otherwise deal with the Company or its affiliates, as if it were not Trustee. The Trustee will initially be
[    ]. 
 13. No Recourse Against Others. A director, officer, incorporator, employee or stockholder, as such,
of the Company shall not have any liability for any obligations of the Company under the Securities or the Indenture or for any claim based on, in respect of or by reason of such obligations or their creation. Each Securityholder by accepting a
Security waives and releases all such liability. The waiver and release are part of the consideration for the issue of the Securities. 

  
 - 4 - 







 14. Authentication. This Security shall not be valid until authenticated by the manual
signature of an authorized signatory of the Trustee or an authenticating agent. 
 15. Abbreviations. Customary abbreviations may be
used in the name of a Securityholder or an assignee, such as: TEN COM (= tenants in common), TEN ENT (= tenants by the entireties), JT TEN (= joint tenants with right of survivorship and not as tenants in common), CUST (= Custodian), and U/G/M/A (=
Uniform Gifts to Minors Act). 
 Pursuant to a recommendation promulgated by the Committee on Uniform Security Identification Procedures the
Company has caused CUSIP numbers to be printed on the Securities. No representation is made as to the accuracy of such numbers (or as to the accuracy of ISIN numbers, Common Code numbers or similar numbers) as printed on the Securities and reliance
may be placed only on the other identification numbers placed thereon. 
 THE COMPANY WILL FURNISH TO ANY SECURITYHOLDER UPON WRITTEN
REQUEST AND WITHOUT CHARGE A COPY OF THE INDENTURE, WHICH HAS IN IT THE TEXT OF THIS SECURITY, IN TWELVE-POINT TYPE. REQUESTS MAY BE MADE TO: INVESTOR RELATIONS, CLOVIS ONCOLOGY, INC., 5500 FLATIRON PARKWAY, SUITE 100, BOULDER, COLORADO 80301,
TELEPHONE: (303) 625-5000. 

  
 - 5 - 







 ASSIGNMENT FORM 

To assign this Security, fill in the form below: 

I or we assign and transfer this Security to 

(Insert assignee’s soc. sec or tax I.D. no.) 
  

 
  

 
 (Print or type assignee’s name,
address and zip code) 
 and irrevocably appoint agent to transfer this Security on the books of the Company. The agent may substitute another to act for
him. 
  

			
	Dated:                                     
                                    	  	Signed:                                     
                                         
           
		  	 (Sign exactly as your name appears on the other side of this Security)


 Signature Guarantee: 

Signatures must be guaranteed by an “eligible guarantor institution” meeting the requirements of the Registrar, which requirements
include membership or participation in the Security Transfer Agent Medallion Program (“STAMP”) or such other “signature guarantee program” as may be determined by the Registrar in addition to, or in substitution for,
STAMP, all in accordance with the Securities Exchange Act of 1934, as amended. 

  
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