Exhibit 10.46


                              EMPLOYMENT AGREEMENT


      THIS EMPLOYMENT AGREEMENT (this "Agreement") is entered into as of
December 31, 2002 between PROTEIN POLYMER TECHNOLOGIES, INC., a Delaware
corporation (the "Company"), and FRANCO A. FERRARI (the "Employee").


                                     RECITAL
                                     -------

      The Company desires to continue to employ the Employee, and the Employee
desires to be so employed by the Company, on the terms and subject to the
conditions set forth in this Agreement. This Agreement supersedes that certain
employment agreement, and any amendments thereto, between the Company and the
Employee dated February 17, 2000 (the "Prior Agreement").


                                     AGREEMENT
                                     ---------

      NOW, THEREFORE, in consideration of the premises and the mutual promises
set forth in this Agreement, the Company and the Employee hereby agree as
follows:

      1. Employment.

         (a) Subject to the terms and conditions contained herein, the Company
hereby agrees to employ the Employee, and the Employee accepts such employment,
from the date hereof until the earlier of (i) December 31, 2005 or (ii) the date
such employment is terminated pursuant to Section 4 of this Agreement. During
the Employee's employment under this Agreement, the Employee shall perform such
duties for the Company as may from time to time be assigned to the Employee by
Board of Directors of the Company (the "Board") or the President of the Company
(the "Designated Officer"). The Employee shall have the title of Vice President,
Laboratory Operations and Polymer Production and Director, Molecular Genetics,
or such other title or titles, if any, as from time to time may be assigned to
the Employee by the Board.

         (b) The Employee will devote his entire business time, energy,
attention and skill to the services of the Company and its affiliates and to the
promotion of their interests. So long as the Employee is employed by the
Company, the Employee shall not, without the written consent of the Company:

             (i) engage in any other activity for compensation, profit or other
pecuniary advantage, whether received during or after the term of this
Agreement;

             (ii) render or perform services of a business, professional, or
commercial nature other than to or for the Company, either alone or as an
employee, consultant, director, officer, or partner of another business entity,
whether or not for compensation, and whether or not such activity, occupation or
endeavor is similar to, competitive with, or adverse to the business or welfare
of the Company; or


<PAGE>


             (iii) invest in or become a shareholder of another corporation or
other entity; provided, that the Employee's investment solely as a shareholder
in another corporation shall not be prohibited hereby so long as such investment
is not in excess of one percent (1%) of any class of shares that are traded on a
national securities exchange.

         (c) Prior to or concurrently with the execution of this Agreement, the
Employee has executed an Employee Proprietary Information, Trade Secret and
Confidentiality Agreement (the "Confidentiality Agreement").

      2. Location of Employment. The Employee's principal place of employment
shall be at the executive offices of the Company located at 10655 Sorrento
Valley Road, San Diego, California 92121 or, as may be requested by the Board,
at any other office of the Company or any of its affiliates currently or
hereinafter located in San Diego County; provided, that at the direction of the
Board or the Designated Officer, the Employee may from time to time be required
to travel to various domestic and foreign locations.

      3. Compensation.

         (a) In exchange for full performance of the Employee's obligations and
duties under this Agreement, the Company shall pay the Employee an annual base
salary (the "Base Salary") equal to $127,000 payable in monthly installments in
accordance with the Company's standard payroll practices. If the Company is
successful in closing an equity financing of $5,000,000 or more prior to March
31, 2003, then the Base Salary shall be equal to $145,000. In any month in which
the Employee shall be employed for less than the entire number of days in such
month, the compensation payable under this Section 3(a) shall be prorated on the
basis of the number of days during which the Employee was actually employed
divided by the number of days in such month.

         (b) The Base Salary is a gross amount, and the Company shall be
required to withhold from such amount deductions with respect to Federal, state
and local taxes, FICA, unemployment compensation taxes and similar taxes,
assessments or withholding requirements.

         (c) During the Employee's employment under this Agreement, the Employee
shall also be reimbursed by the Company for reasonable business expenses
actually incurred or paid by the Employee, consistent with the policies
established by the Board, in rendering to the Company the services provided for
in this Agreement, upon presentation of expense statements or such other
supporting information as is consistent with the policies of the Company.

         (d) The Employee shall be entitled to 20 business days vacation for
each full year of employment under this Agreement, which vacation time will
accrue in accordance with the vacation policy of the Company.


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<PAGE>


         (e) The Employee shall be entitled to participate in all benefit plans
(including deferred compensation plans and any medical, dental or life insurance
plans) which shall be available from time to time to the domestic management
employees of the Company generally, except to the extent such participation in
any plan would, in the opinion of the Designated Officer, alter the intended tax
treatment of such plan; provided, however, that the Employee shall have no right
under this Agreement to participate in any stock option, stock purchase or other
plan relating to shares of capital stock of the Company or its affiliates. The
Employee acknowledges and agrees that the Board may in its discretion terminate
at any time or modify from time to time any such benefit plans.

         (f) Other than as expressly set forth in this Section 3 or Sections
4(f) and 4(g) below, the Employee shall not receive any other compensation or
benefits except to the extent provided by the Board.

      4. Termination.

         (a) The employment of the Employee under this Agreement may be
terminated by the Company immediately upon giving the Employee notice if (i) the
Board determines that the Employee is unable to discharge his essential job
duties by reason of illness or injury or (ii) the Employee has been unable to
discharge his essential job duties by reason of illness or injury for either (A)
a period of two consecutive months or (B) twelve weeks in any twelve-month
period.

         (b) The employment of the Employee under this Agreement shall terminate
on the date of the Employee's death.

         (c) The employment of the Employee under this Agreement may be
terminated by the Company upon written notice from the Board that, in the
opinion of the Board, the Employee has (i) refused or failed (after reasonable
notice that such refusal or failure would result in termination of the
Employee's employment) to perform, to the satisfaction of the Designated Officer
or the Board, any duties assigned to the Employee by the Designated Officer or
the Board, (ii) committed a breach of the terms of this Agreement or any other
legal obligation to the Company, (iii) failed to perform any of the Employee's
obligations under the Confidentiality Agreement, (iv) demonstrated negligence or
willful misconduct in the execution of the Employee's assigned duties, (v) been
convicted of or pleaded nolo contendere to a felony or other serious crime, (vi)
repeatedly and intemperately used alcohol or drugs, (vii) engaged in business
practices which, in the opinion of the Board, are unethical or reflect adversely
on the Company, (viii) misappropriated assets of the Company or (ix) been
repeatedly absent from work during normal business hours for reasons other than
disability.

         (d) The employment of the Employee under this Agreement shall terminate
upon receipt by the Board of a written notice of resignation signed by the
Employee or, if no notice is given, on the date on which the Employee
voluntarily terminates his or her employment relationship with the Company.


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<PAGE>


         (e) In addition to the circumstances described in subsections (a), (b),
(c) and (d) above, the Company may terminate the Employee's employment for any
reason or no reason and with or without cause or prior notice. The Employee
understands that, subject to subsections (f)(iii) and (g) below, he is an
at-will employee and may be terminated by the Company without cause or prior
notice pursuant to this subsection (e) notwithstanding any other provision
contained in this Agreement. This at-will relationship will remain in effect
during the term of this Agreement and so long thereafter provided that the
Employee remains employed by the Company, unless such at-will employment
relationship is modified by a specific, express written agreement signed by the
Company.

         (f) If the Employee's employment is terminated pursuant to this Section
4 or for any other reason, the Employee shall not be entitled to any
compensation or benefits from the Company, under Section 3 of this Agreement or
otherwise, except for the following:

             (i) Base Salary and vacation pay accrued, and reasonable business
expenses incurred, under Section 3 of this Agreement through the date of such
termination;

             (ii) such benefits, if any, as may be required to be provided by
the Company under the Comprehensive Omnibus Budget Reconciliation Act (COBRA);

             and

             (iii) if the Employee's employment is terminated pursuant to
subsection (e) above, and the Company has cash and cash equivalents of at least
$800,000, as reflected on the Company's most recent balance sheet as set forth
in its most recent periodic filing with the Securities and Exchange Commission
(the "SEC"), the Company shall continue to pay to the Employee the Base Salary
then in effect at intervals in accordance with the Company's standard payroll
practice until the earlier of (A) three months following such termination or (B)
the termination date set forth in Section 1(a)(i) of this Agreement.

         (g) Employee may terminate his employment hereunder for "Good Reason"
(as hereinafter defined).

             (i) For purposes of this Agreement, "Good Reason" shall mean a
termination of Employee's employment by Employee within 90 days after the
occurrence of any of the following after a "Change in Control" (as hereinafter
defined): (i) a reduction in Employee's Base Salary then in effect; (ii) a
material reduction in Employee's positions, duties and responsibilities from
those described in Section 1(a) of this Agreement; or (iii) the failure of the
Company to obtain the assumption of this Agreement by any successor to the
extent required pursuant to Section 10(a) of this Agreement.


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             (ii) For purposes of this Agreement, the term "Change in Control"
shall mean the occurrence of any of the following events with respect to the
Company:

                (A) All or substantially all of the assets of the Company are
sold or transferred to another corporation or entity; or

                (B) The Company is sold, transferred, merged, consolidated,
ventured or reorganized into or with another corporation or entity, with the
result that upon conclusion of the transaction less than a majority of the
outstanding securities entitled to vote generally in the election of directors
or other capital interests of the acquiring corporation or entity are owned,
directly or indirectly, by the shareholders of the Company immediately prior to
the sale, transfer, merger, consolidation, venture or reorganization; or

                (C) There is a report filed on Schedule 13D or Schedule 14D-1
(or any successor schedule, form or report), each as promulgated pursuant to the
Securities Exchange Act of 1934, as amended (the "Exchange Act"), disclosing
that any person (as the term "person" is used in Section 13(d)(3) or Section
14(d)(2) of the Exchange Act) has become the beneficial owner (as the term
"beneficial owner" is defined under Rule 13d-3 or any successor rule or
regulation promulgated under the Exchange Act) of securities representing more
than 50% of the combined voting power of the then-outstanding voting securities
of the Company; or

                (D) The Company shall file a report or proxy statement with the
Securities and Exchange Commission pursuant to the Exchange Act disclosing in
response to Item 1 of Form 8-K thereunder or Item 14 of Schedule 14A thereunder
(or any successor schedule, form or report or item therein) that a change in
control of the Company has or may have occurred or will or may occur in the
future pursuant to any then-existing contract or transaction; or

                (E) The individuals who, at the beginning of any period of two
consecutive calendar years, constituted members of the Board cease for any
reason to constitute at least a majority thereof unless the nomination for
election by the Company's stockholders of each new director of the Company was
approved by a vote of at least two-thirds of the directors of the Company still
in office who were Directors of the Company at the beginning of any such period.

             (iii) Notwithstanding the foregoing, a termination shall not be
treated as a termination for Good Reason (i) if Employee shall have specifically
consented in writing to the occurrence of the event giving rise to the claim of
termination for Good Reason or (ii) unless Employee, within 30 days after
receiving written notice from the Company specifying in reasonable detail the
occurrence of one of such events, shall have delivered a written notice to the
Company stating that he intends to terminate his employment for Good Reason and
specifying the factual basis for such termination and


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<PAGE>


such event, if capable of being cured, shall not have been cured within 30 days
of the receipt by the Company of such notice.

             (iv) If Employee shall terminate his employment for Good Reason,
the Company shall pay Employee (or, in the event of his death, his devisee,
legatee or, if there is none, his estate) a lump-sum amount equal to the highest
level of Employee's annual Base Salary in effect on the date of the Change in
Control, multiplied by a factor of 2.0. Employee will also be entitled to any
vested benefits under any employee benefit plans.

      5. Employee's Representations.

         (a) The Employee represents that he has full authority to enter into
this Agreement and that he is free to enter into this Agreement and not under
any contractual restraint which would prohibit the Employee from satisfactorily
performing his duties to the Company under this Agreement.

         (b) The Employee hereby agrees to indemnify and hold harmless the
Company, its officers, directors and stockholders from and against any losses,
liabilities, damages or costs (including reasonable attorney's fees) arising out
of a breach, or claimed breach, of any of the representations, warranties and
covenants of the Employee set forth in this Agreement.

         (c) The Employee acknowledges that he is free to seek advice from
independent counsel with respect to this Agreement. The Employee has either
obtained such advice or, after carefully reviewing this Agreement, has decided
to forego such advice. The Employee is not relying on any representation or
advice from the Company or any of its officers, directors, attorneys or other
representatives regarding this Agreement, its content or effect.

      6. Arbitration. Any controversy or claim arising out of or relating to
this Agreement or any breach hereof or the Employee's employment by the Company
or termination thereof, shall be settled by arbitration by one arbitrator in
accordance with the rules of the American Arbitration Association, and judgment
upon such award rendered by the arbitrator may be entered in any court having
jurisdiction thereof. The arbitration shall be held in the City of San Diego or
such other place as may be agreed upon at the time by the parties to the
arbitration.

      7. Equitable Relief. The Employee acknowledges that the Company is relying
for its protection upon the existence and validity of the provisions of this
Agreement, that the services to be rendered by the Employee are of a special,
unique and extraordinary character, and that irreparable injury will result to
the Company from any violation or continuing violation of the provisions of this
Agreement for which damages may not be an adequate remedy. Accordingly, the
Employee hereby agrees that in addition to the remedies available to the Company
by law or under this Agreement, the Company shall


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be entitled to obtain such equitable relief as may be permitted by law in a
court of competent jurisdiction including, without limitation, injunctive relief
from any violation or continuing violation by the Employee of any term or
provision of this Agreement.

      8. Governing Law. This Agreement shall be governed by and construed and
enforced in accordance with the internal substantive laws (and not the laws of
conflicts) of the State of California.

      9. Entire Agreement. This Agreement constitutes the whole agreement of the
parties hereto in reference to any employment of the Employee by the Company and
in reference to any of the matters or things herein provided for or hereinabove
discussed or mentioned in reference to such employment; all prior agreements,
promises, representations and understandings relative thereto (including,
without limitation, the Prior Agreement) being herein merged.

      10. Assignability.

         (a) In the event the Company shall merge or consolidate with any other
corporation, partnership or business entity, or all or substantially all of the
Company's business or assets shall be transferred in any manner to any other
corporation, partnership or business entity, then such successor to the Company
shall thereupon succeed to, and be subject to, all rights, interests, duties and
obligations of, and shall thereafter be deemed for all purposes hereof to be,
the "Company" under this Agreement. This Agreement shall inure to the benefit of
and be enforceable by Employee's personal or legal representatives, executors,
administrators, successors, heirs, distributees, devisees and legatees. If
Employee should die, any amounts payable to him hereunder shall be paid in
accordance with the terms of this Agreement to Employee's devisee, legatee, or
other designee or, if there be no such designee, to his estate.

         (b) This Agreement is personal in nature and the Employee shall not,
except as set forth in subsection (a) hereof, without the written consent of the
Company, assign or transfer this Agreement or any rights or obligations
hereunder.

         (c) Except as set forth in subsection (a) above, nothing expressed or
implied in this Agreement is intended or shall be construed to confer upon or
give to any person, other than the parties to this Agreement, any right, remedy
or claim under or by reason of this Agreement or of any term, covenant or
condition of this Agreement.

      11. Amendments; Waivers. This Agreement may be amended, modified,
superseded, canceled, renewed or extended and the terms or covenants of this
Agreement may be waived only by a written instrument executed by the parties to
this Agreement or, in the case of a waiver, by the party waiving compliance. Any
such written instrument must be approved by the Board to be effective as against
the Company. The failure of any party at any time or times to require
performance of any provision of this Agreement shall in no manner affect the
right at a later time to enforce the same. No waiver by any


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party of the breach of any term or provision contained in this Agreement,
whether by conduct or otherwise, in any one or more instances, shall be deemed
to be, or construed as, a further or continuing waiver of any such breach, or a
waiver of the breach of any other term or covenant contained in this Agreement.

      12. Notice. All notices, requests or consents required or permitted under
this Agreement shall be made in writing and shall be given to the other parties
by personal delivery, overnight air courier (with receipt signature) or
facsimile transmission (with "answerback" confirmation of transmission), sent to
such parties' addresses or telecopy numbers as are set forth below such parties'
signatures to this Agreement, or such other addresses or telecopy numbers of
which the parties have given notice pursuant to this Section 12. Each such
notice, request or consent shall be deemed effective upon the date of actual
receipt, receipt signature or confirmation of transmission, as applicable.

      13. Severability. Any provision of this Agreement that is prohibited or
unenforceable in any jurisdiction shall, as to such jurisdiction, be ineffective
to the extent of such prohibition or unenforceability without invalidating the
remaining provisions hereof, and any such prohibition or unenforceability in any
jurisdiction shall not invalidate or render unenforceable such provision in any
other jurisdiction.

      14. Survival. The representations and agreements of the Employee set forth
in Sections 5, 6 and 7 of this Agreement shall survive the expiration or
termination of this Agreement (irrespective of the reason for such expiration of
termination).

      15. Attorney's Fees. If any party to this Agreement seeks to enforce his
or its rights under this Agreement, the prevailing party or parties shall be
entitled to recover reasonable fees, costs and expenses incurred in connection
therewith including, without limitation, the fees, costs and expenses of
attorneys, accountants and experts, whether or not litigation is instituted, and
including such fees, costs and expenses of appeals.

                            [Signature page follows]


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      IN WITNESS WHEREOF, the parties to this Agreement have executed this
Employment Agreement as of the date first above written.



                              PROTEIN POLYMER TECHNOLOGIES, INC.



                              By /s/ J. Thomas Parmeter
                                 ----------------------
                                    Its President
                                        ---------------

                              Address for Notices:

                              10655 Sorrento Valley Road
                              First Floor
                              San Diego, California 92121
                              Attention:  J. Thomas Parmeter
                              Telecopy:  (619) 558-6477

                              /s/ Franco A. Ferrari
                              ---------------------------
                              FRANCO A. FERRARI

                              Address for Notices:

                              -------------------------------
                              -------------------------------
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