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                                                                   Exhibit 10.42

                                                                  EXECUTION COPY

                          SUPPLY AND SERVICES AGREEMENT

         THIS SUPPLY AND SERVICES AGREEMENT is entered into as of December 19,
2005 (the "Effective Date") by and between PROTEIN POLYMER TECHNOLOGIES, INC., a
Delaware corporation ("Company") and SURGICA CORPORATION, a Delaware corporation
("Surgica"). Company and Surgica are each hereinafter referred to as a "Party"
and collectively as the "Parties".

                              W I T N E S S E T H:

         WHEREAS, Company and Surgica have entered into an Asset Purchase Option
Agreement, dated as of November 23, 2005 (the "Option Agreement"), pursuant to
which Company, among other things, obtained the right to purchase from Surgica
substantially all of the assets of Surgica then existing or thereafter acquired
through the date of the exercise of the Option (as that term is defined in the
Option Agreement);

         WHEREAS, in connection with the Option Agreement and this Agreement,
the Parties are entering into a separate License Agreement of even date herewith
(the "License Agreement") wherein Company acquires from Surgica an exclusive
license to Intellectual Property for use in the Field;

         WHEREAS, Surgica has experience in the development of Products and has,
or will have as a result of the Parties fulfilling their obligations hereunder,
the facilities, equipment, employees, materials and other resources to
accomplish development and manufacturing activities, on behalf of Company, with
respect to the Intellectual Property; and

         WHEREAS, as partial consideration offered by Surgica to induce Company
to enter into the Option Agreement, Surgica desires to supply certain services
and manufactured goods and materials to Company and receive certain services
from Company.

         NOW, THEREFORE, in consideration of the premises and mutual covenants
and agreements herein set forth and for other good and valuable consideration,
the receipt and adequacy of which are hereby acknowledged, the Parties hereto
hereby agree as follows:

1.    Definitions. All capitalized terms used but not defined in this Agreement
shall have the meanings ascribed thereto in the License Agreement. The following
terms shall have the meanings set forth below:

      1.1   "Clinical Use" shall mean use in humans.

      1.2   "Deliverable" shall mean services, materials or items to be
delivered by one Party to the other under this Agreement pursuant to a Project
Plan.

      1.3 "Delivery Dates" shall mean the delivery dates for specific orders of
Product as may be specified by Company in its reasonable discretion in a Project
Plan or Order.

      1.4 "ECA" means the European Competent Authorities, any Notified Bodies,
or any successor agencies responsible for European Regulatory Approvals.

      1.5 "Surgica Financial Difficulty" shall mean the occurrence of: (a)
filing in any court pursuant to any statute, a petition in bankruptcy or
insolvency or for reorganization in bankruptcy or for an arrangement or for the
appointment of a receiver or trustee for such Party of its assets; (b) being
served with an involuntary petition against it, filed in any insolvency
proceeding, and where such petition has not been dismissed within sixty (60)
days after the filing thereof; (d) proposing or being a party to any
dissolution; or (e) making an assignment for the benefit of creditors.

      1.6 "Fully-Burdened Cost" shall mean all of the direct and proportional
indirect costs and expenses for providing the specified Product or services,
including but not limited to raw materials and supplies, labor, equipment,
utilities, facilities and overhead as determined according to generally accepted
accounting principles (GAAP) consistently applied. Specifically, with respect to
Company's Fully-Burdened Costs, such Fully-Burdened Costs shall include, without
limitation, amounts paid to Surgica pursuant to the applicable budgets provided
for herein.

      1.7 "Governmental Body" means any: (a) nation, principality, state,
commonwealth, province, territory, county, municipality, district or other
jurisdiction of any nature; (b) federal, state, local, municipal, foreign or
other government; (c) governmental or quasi-governmental authority of any nature
(including any governmental division, subdivision, department, agency, bureau,
branch, office, commission, council, board, instrumentality, officer, official,
representative, organization, unit, body or entity and any court or other
tribunal); (d) multi-national organization or body; or (e) individual, entity or
body exercising, or entitled to exercise, any executive, legislative, judicial,
administrative, regulatory, police, military or taxing authority or power of any
nature.

      1.8 "Non-Clinical Use" shall mean use other than in humans.

      1.9 "Company Facilities" shall mean Company's offices and laboratory space
located at 10655 Sorrento Valley Road, San Diego, California 92121 or, in the
event Company no longer maintains offices and laboratory space at such address,
such new address as Company shall maintain offices and/or laboratory space.

      1.10 "Company's Technology" shall mean all inventions, discoveries,
know-how, works of authorship, methods, processes, data, information,
technology, research tools, techniques, processes, methods, compositions,
tangible materials (including, without limitation, vectors, proteins, assays and
the like), formulas and all other scientific or technical information or
materials, in whatever form, and all rights embodied in intellectual property
therein and thereto anywhere in the world, that are owned, controlled or
licensed-in by Company (excluding any Intellectual Property licensed-in from
Surgica or its Affiliates) and Company's Confidential Information, and all
embodiments thereof.

      1.11 "Cost of Goods Sold" or "COGS" shall have the definition set forth in
Section 5.5.1.3.

                                       2

      1.12 "Product" shall mean Products as defined in the License Agreement
provided by Surgica to Company that are set forth in the applicable Project Plan
or Order under this Agreement.

      1.13 "Project" shall mean a project referred to in Section 2 below and as
further defined in each Project Plan (defined in Section 2.2 below).

      1.14 "Project Technology" shall mean all inventions, discoveries,
know-how, works of authorship, methods, processes, data, information,
technology, research tools, techniques, processes, methods, compositions,
tangible materials, formulas and all other scientific or technical information
or materials, in whatever form, that are invented, discovered, developed or
otherwise generated by either Party, their respective Affiliates or both Parties
jointly during and in the course of the obligations set forth herein and in each
Project Plan hereunder, and conducted pursuant hereto and thereto, and all
rights embodied in intellectual property therein and thereto anywhere in the
world.

      1.15 "Regulatory Agency" means (a) the FDA, (b) the ECA, or (c) any other
Governmental Body with regulatory authority similar to the FDA or ECA in any
other jurisdiction anywhere in the world.

      1.16 "Regulatory Approval" shall mean with respect to any country, filing
for and receipt of all regulatory agency or other registrations, clearances and
approvals required in such country in respect of Product for any purpose
specified in this Agreement or, if no purpose is specified, to enable Product to
be manufactured, offered for sale, sold and distributed, and for Non-Clinical
Use or Clinical Use to take place, in such country.

      1.17 "Surgica's Technology" shall mean all inventions, discoveries,
know-how, works of authorship, methods, processes, data, information,
technology, research tools, techniques, processes, methods, compositions,
tangible materials, formulas and all other scientific or technical information
or materials, in whatever form, and all rights embodied in Intellectual Property
therein and thereto anywhere in the world, that are owned, controlled or
licensed-in by Surgica (excluding any intellectual property licensed-in from
Company or its Affiliates) and Surgica's Confidential Information, and all
embodiments thereof.

      1.18 "Surgica Budget" shall mean the currently approved budget for
Surgica's operations under approved Project Plans.

2.    Project Development.

      2.1  Management Committee; Project Coordinators. As of the Effective Date,
the Parties have formed a Management Committee (the "Committee") to oversee the
Parties' rights and obligations under this Agreement. Each Party shall designate
in Exhibit A attached hereto one (1) individual who will be the initial "Project
Coordinator" for such Party and up to two (2) representatives (each, a
"Representative"). Together, the Project Coordinators shall (a) serve on the
Committee, (b) have management authority, (c) facilitate day-to-day
communications between the Parties, (d) monitor the schedules and progress of,
and have responsibility for, the work performed under this Agreement, (e)
receive and submit requests for information and/or assistance, (f) supervise the
exchange of Confidential Information (defined in Section 10 below),

                                       3

and (g) designate its authority to one or more of the responsibilities listed in
clauses (a) through (f) above to its respective representative(s). Company's
Project Coordinator shall serve as the chair person of the Management Committee.
The Project Coordinators will meet (including telephonically) as is required by,
or reasonably desirable to, Company to discuss the progress of the development
effort for each Project and, if applicable, to exchange information and
Deliverables. Neither Party's Project Coordinator is authorized to amend, alter
or extend this Agreement in any manner. All disputes concerning one or more
Projects shall be resolved by the chair person of the Management Committee. Each
Party may change its Project Coordinator and/or Representative(s) at any time,
and from time to time, by giving the other Party prior written notice.

      2.2  Preparation of Project Plan. For each Project that the Parties
undertake under this Agreement, the Committee shall prepare a project plan
("Project Plan") setting forth the goals and objectives of, and Surgica's budget
for, the Project, identified with respect to the Parties' responsibilities. The
Parties agree that the Project Plan shall automatically, without any further
action by the Parties, incorporate the terms and conditions of this Agreement.
The Project Plan shall be reviewed quarterly by the Committee and may be
amended, but only if such amendment is in writing and signed by each Project
Coordinator. In the event of any conflict between any terms of this Agreement
and the terms set forth in any Project Plan, the terms of this Agreement shall
govern.

      2.3  Project Plan No. 1. Prior to the Effective Date, the Parties shall
agree upon a Project Plan (which shall be adopted by the Committee upon the
Effective Date) under which Surgica shall [*****] as more specifically set
forth in Schedule 2.3 attached hereto ("Project Plan No. 1"). Surgica shall use
commercially reasonable efforts to (i) collaborate with and assist Company with
obtaining all necessary certifications and Regulatory Approval concerning
Project Plan No. 1; and (ii) provide data and technical support as reasonably
requested by Company in connection with Company's fulfillment of its obligations
under Project Plan No. 1.

      2.4  Surgica Budget. As of the Effective Date, the Parties agree that the
Project Plan No. 1 Budget shall be the Surgica Budget for the first year under
this Agreement. Every six (6) months, the Committee shall prepare an updated
budget for the succeeding twelve (12) months, taking into consideration progress
against the Sales Forecast and each Project Plan. The updated Surgica Budget
shall be approved in writing by the Company's Project Coordinator.
Notwithstanding the foregoing, the Surgica Budget may be adjusted from time to
time, and at any time, upon the prior written approval of Company's Project
Coordinator. According to the Surgica Budget then in effect, Surgica shall
invoice company monthly in advance and Company shall pay Surgica the invoiced
amount within ten (10) days.

      2.5  Surgica Budget Reconciliation. No later than fifteen (15) days after
the conclusion of each calendar quarter, Surgica shall complete a review of its
actual expenses under the applicable Project Plan(s) and reconcile and compare
such actual expenses against the sum of all payments (including, without
limitation, any credits that result from the reconciliation of the Surgica
Budget from any prior calendar quarter(s)) made during the calendar quarter just

[*****] Material is confidential and has been omitted and filed separately with
the Securities and Exchange Commission.

                                       4

concluded by Company (i) pursuant to the Surgica Budget, and (ii) that were made
to Surgica or on behalf of Surgica, to a third party, that, in Company's sole
discretion, were reasonably necessary or desirable to reduce the risk of an
event of a Surgica Financial Difficulty ("Budget Payments"). Surgica shall
provide an accurate report of the results of its review to Company upon
completion. If Company's Budget Payments exceed Surgica's actual expenses
(including any amounts paid by Company on behalf of Surgica) during the reviewed
calendar quarter, Company may apply the difference (i.e., the amount of Budget
Payments that was in excess of Surgica's actual expenses during the reviewed
period) to its next Budget Payment(s) to Surgica.

      2.6  Submission of Project Proposals for Additional Projects. Either Party
may submit to the Project Coordinators a project proposal describing the
Project, the work to be performed, and to the extent then determinable, a
preliminary development schedule. The Project Coordinators shall each promptly
review and evaluate the project proposal. If the Project Coordinators each agree
to pursue the subject matter of the proposal, the Committee shall prepare a
Project Plan. Approval of a Project Plan shall be effective only if the
president and/or chief executive officer of each Party approves the Project Plan
in writing. Each Project Coordinator will notify the other of approval or
rejection of a Project Plan or may propose modifications to a Project Plan. Any
Project Plan not approved by both Parties within thirty (30) days following
submission shall be deemed rejected. Upon the approval of any additional Project
Plan, the Surgica Budget shall be revised as required, subject to the prior
written approval of Company's Project Coordinator.

      2.7  Development Obligations. Each Party shall use its commercially
reasonable efforts to undertake and complete each Project in accordance with,
and substantially on the schedule specified in, the applicable Project Plan.
Notwithstanding the foregoing, prior to the expiration of the Option Period (as
that term is defined in the Option Agreement), Surgica shall prioritize and
utilize one hundred percent of its resources to and for the work performed under
this Agreement. Company shall provide Surgica with a monthly statement
describing Company's Fully-Burdened Costs incurred under this Agreement.

      2.8  Acceptance by Company.
           ---------------------

           2.8.1 When Surgica has completed a Deliverable due under a Project
Plan, Surgica shall deliver it to Company. Company may reject a Deliverable by
providing Surgica with a written notice describing the Deliverable's failure to
meet a material requirement stated in the applicable Project Plan (a
"Nonconformity").

           2.8.2 Following rejection of a Deliverable pursuant to this Agreement
due to a Nonconformity, Surgica will use commercially reasonable efforts to
promptly correct such Nonconformity. When it has made the necessary corrections,
Surgica will again deliver the Deliverable to Company and the
acceptance/rejection/correction provisions of Section 2.6.1 above shall be
reapplied until the Deliverable is accepted; provided, however, that upon the
third or any subsequent rejection, Company may terminate this Agreement by
thirty (30) days prior written notice unless the Deliverable is accepted during
the notice period.

      2.9  Costs and Expenses. Except as otherwise provided herein, each Party
shall bear its own costs and expenses incurred by it in performing work under
this Agreement.

                                       5

      2.10  Site Visits. For purposes of reviewing the progress of any Project,
the Parties may facilitate an exchange of technical personnel to work on-site at
each other's facilities. Company shall be free to visit those portions of
Surgica's facilities where work on the Project is being conducted. Such visits
shall be at reasonable intervals following reasonable notice during regular
business hours. Each Party shall indemnify and hold the other Party harmless
from and against any liability arising from the activities of its employees in
the other Party's facilities.

      2.11 Project Delays; Project Failure. If at any time during the course of
any Project, either Party (the "Delaying Party") anticipates that it will not be
able to meet any milestone or other target or deadline for which it is
responsible by the date set forth on the applicable Project Plan or established
by the Management Committee, the Delaying Party shall so notify the other Party
(the "Affected Party") in writing specifying the reasons for delay. From and
after such notice, the Parties shall cooperate and use diligent efforts to solve
the problems identified, and the milestone dates or other deadlines may, with
the Affected Party's written approval, be set back for as long a period as is
required to solve the problems so identified; provided, however, that if for any
reason other than due to the fault of Company, Surgica fails or will fail to
complete a milestone or other target or deadline, then Company may terminate
this Agreement immediately on written notice pursuant to Section 12 below.

      2.12 Inventory Services. Surgica shall provide inventory services to
Company including, without limitation, reasonable facilities to store inventory
of Product developed and/or manufactured hereunder.

3.    Ownership.

      3.1  Company's Technology and Project Technology. Except as expressly and
unambiguously licensed herein or in the License Agreement, as between the
Parties, Company shall retain and exclusively own all rights, title and interest
(including all intellectual property and proprietary rights throughout the
world) in and to Company's Technology and the Project Technology, and any and
all improvements, modifications and derivative works thereof created hereunder
(by whomever produced).

           3.1.1 Assignment. Surgica agrees to assign and does hereby assign to
Company all rights, title and interest including, without limitation, copyright
rights, patent rights, trade secret rights, mask work rights and all other
intellectual property and proprietary rights that Surgica may have or acquire
throughout the world in and to any improvements, modifications and derivative
works of Company's Technology or the Project Technology made, conceived or
reduced to practice, alone or with others, during the course of development
under this Agreement or any Project Plan. The foregoing shall apply to all
rights of every kind and character whatsoever throughout the world, whether or
not such rights are now existing or come into existence hereafter, and whether
or not such rights are now known, recognized or contemplated. Surgica agrees to
perform, during and after the term of this Agreement, all acts deemed necessary
or desirable by Company to permit and assist it in evidencing, recording and
perfecting such assignment and to enforce, maintain and defend the rights being
assigned hereunder. In connection with such assignment, Surgica irrevocably
designates and appoints Company its agent and attorney-in-fact to act for and in
its behalf to execute, register and file any applications, and to perform all
other lawfully permitted acts, to further the registration,

                                       6

prosecution and issuance of copyrights, patents, trademarks and similar
protections with the same legal force and effect as if executed by Surgica.

      3.2  Surgica's Technology. As between the Parties, Surgica shall retain
and exclusively own all title to and, except as expressly and unambiguously
licensed herein or in the License Agreement, all rights and interest (including
all intellectual property and proprietary rights throughout the world) in
Surgica's Technology and any and all improvements, modifications and derivative
works thereof (by whomever produced).

      3.3  Protective Filings. Company shall have the exclusive right and be
responsible for determining whether and to what extent to file applications for
copyrights, patents, trademarks and similar protections and to maintain any
issued copyrights, trademarks, patents and similar protections (and all
divisions, continuations, continuations in part, reissues, reexaminations or
extensions thereof) anywhere in the world relating to Company's Technology, the
Project Technology and, to the extent it is licensed to Company hereunder or
pursuant to the License Agreement, Surgica's Technology. Surgica shall fully
cooperate with Company as may be necessary for the preparation, filing and
prosecution of each such application and for maintenance, renewal and defense of
each copyright, trademark, patent or similar protection granted, including
executing all documents and maintaining and furnishing all records reasonably
necessary to perform such acts concerning the Project Technology and/or
Surgica's Technology. Company shall provide Surgica with a complete copy of each
patent application and all communications received from, or sent to, the United
States Patent and Trademark Office and foreign government patent offices
concerning Surgica's Technology, to the extent applicable.

      3.4  Regulatory Approvals. Company shall be responsible for all filings
with Regulatory Agencies related to Product throughout the world. All regulatory
submissions and Regulatory Approvals concerning Company's Technology, the
Project Technology and, to the extent it is licensed to Company hereunder or
pursuant to the License Agreement, Surgica's Technology, shall be held by and in
the name of Company or its designees.

4.    License Grant.

      4.1  By Company. Subject to all of the terms and conditions of this
Agreement and any Project Plan, Company hereby grants to Surgica a royalty-free,
non-exclusive, non-transferable, non-sublicensable and worldwide license for the
term of this Agreement to:

           4.1.1 make, use, reproduce, modify and create any derivative works of
any Project Technology; and

           4.1.2 make, use, reproduce, modify and create derivative works of
Company's Technology solely for the purpose of performing its development
obligations pursuant to this Agreement and strictly in accordance with, and
subject to the limitations set forth in, the applicable Project Plan.

      4.2 By Surgica. Subject to all of the terms and conditions of this
Agreement and any Project Plan, Surgica hereby grants to Company:

                                       7

           4.2.1 a non-exclusive, non-transferable, non-sublicensable,
royalty-free and worldwide license for the term of this Agreement to make, have
made, use, reproduce, modify and create derivative works of Surgica's Technology
for the purpose of performing its development obligations pursuant to this
Agreement and strictly in accordance with the applicable Project Plan.

5.    Supply of Products; Post-Supply Obligations.

      5.1 Supply. Surgica, within the limitations contained in this Section 5,
shall exclusively sell to Company such quantities of Product for Clinical Use as
Company may order through a purchase order ("Order"), subject to the terms
thereof. Surgica shall provide to Company Product for Non-Clinical Use as may be
reasonably requested by Company from time to time.

      5.2  Quantity.
           --------

           5.2.1 Within ten (10) days of Effective Date, with respect to each
Product described in Project Plan No. 1, Company shall deliver to Surgica a
good-faith forecast of Company's estimated quantity requirements for such
Product for the succeeding twelve (12) months (the "Sales Forecast"), which
Company shall update quarterly. With respect to Product developed pursuant to
additional Project Plans, Company shall provide such forecast no later than
three (3) months prior to the anticipated date of Regulatory Approval. Surgica
shall reasonably manage its capacity, resources and inventory to ensure a supply
of Product in inventory to completely and timely satisfy Company's estimates and
forecasts. The failure of Surgica to supply Company with Product pursuant to the
Sales Forecast shall be a material breach of this Agreement.

      5.3  Delivery.
           --------

           5.3.1 Prior to the release of any Product lot into Surgica's
inventory for Clinical Use, Surgica shall (a) provide to Company all documents
necessary (or reasonably requested by Company) to permit Company to confirm that
the applicable lot meets the applicable specifications, including without
limitation copies of all certificates, reports, test results or other
information produced by Surgica, or by a third party consultant or contractor at
Surgica's request, and (b) obtain written approval from Company that Company has
reviewed and is satisfied that the applicable lot meets such specifications.

           5.3.2 All Products ordered pursuant to an Order shall be delivered to
Company or its designee(s) as specified in the Order, F.O.B. Surgica's plant or
other place of shipment. Surgica shall deliver Product by the applicable
Delivery Dates and assist Company in arranging any desired insurance (in amounts
that Company shall determine) and transportation. All customs, duties, costs,
taxes, insurance premiums, and other expenses relating to such transportation
and delivery shall be at Company's expense.

           5.3.3 Surgica will package Product for shipment in accordance with
the specifications set forth in applicable Project Plan or Order, as applicable.

      5.4  Rejection of Product in Case of Nonconformity.
           ---------------------------------------------

                                       8

           5.4.1 Company may reject any lot of Product which is (i) not
conforming with the specifications for the applicable Product or (ii)
adulterated or misbranded within the meaning of the Federal Food, Drug and
Cosmetic Act (the "Act").

                 5.4.1.1 In order to reject a Product lot, Company must (i) give
notice to Surgica of Company's intent to reject the lot within fifteen (15) days
of receipt of the documentation specified in 5.3.1 (a) together with a written
indication of the reasons for such rejection. After notice of intent to reject
is given, Company shall cooperate with Surgica in determining whether rejection
is necessary or justified. In the case of Products having latent defects which
upon diligent examination by Company could not have been discovered, Company
must give notice of Company's intent to reject within five (5) days after
discovery of such defects, provided that such notice may in no event be given
later than one hundred and eighty (180) days after Company's approval of the lot
for release to inventory. In the event that any Product is found to be defective
within such one hundred and eighty (180) day period by Company, a Company
customer or subcontractor, Surgica shall credit Company against any royalty
payments due for the total cost of the defective Product, plus all other costs
incurred, including, but not limited to the costs of other materials, subsequent
processing costs, transportation costs, and the costs of product recalls.

                 5.4.1.2 In any event, Company shall pay for the Product as
otherwise provided herein and shall be entitled to a refund of the purchase
price (together with insurance and freight charges) of properly rejected
Products at the time they are ultimately rejected, provided that if Surgica
disputes the rejection, credit shall be made against the royalty due Surgica, if
at all, at the time the dispute is finally resolved. Surgica shall notify
Company as promptly as reasonably possible whether it accepts Company's basis
for any rejection and, in no event, later than fifteen (15) days after receipt
of Company's notice of rejection.

           5.4.2 Whether or not Surgica accepts Company's basis for rejection,
promptly on receipt of a notice of rejection, Surgica shall use its best
efforts, at Company's request, to provide replacement Product which shall be
purchased by Company as provided in this Agreement.

           5.4.3 Unless Surgica requests the return to it of a defective lot
within thirty (30) days of receipt of Company's notice of rejection, Company
shall destroy such lot promptly and provide Surgica with certification of such
destruction. Company shall, upon receipt of Surgica's request for return,
promptly dispatch said lot to Surgica, at Surgica's cost, expense and risk, such
cost and expense to be credited against any royalty due Surgica.

                                       9

      5.5  Price and Payments.
           ------------------

           5.5.1 Price.
                 -----

                 5.5.1.1 Non-Clinical Use Product. Surgica shall [*****] for
reasonable amounts of Product for Non-Clinical Use.

                 5.5.1.2 Interim Period. Until Company's Net Sales of Product
for Clinical Use exceeds its Fully-Burdened Costs, the price for Product for
Clinical Use shall be the price set in the applicable Project Plan, as may be
amended from time to time by mutual written agreement of the Parties.

                 5.5.1.3 Post-Interim Period. If Company's Net Sales of Product
exceeds its Fully-Burdened Costs, the Parties shall mutually determine the Cost
of Goods Sold ("Cost of Goods Sold" or "COGS"), which shall be based upon a
rigorous analysis of relevant overhead and actual labor in production. Upon
determination and mutual written agreement of COGS for each applicable Product
for Clinical Use, the applicable Project Plan shall be amended to include such
definition and all applicable Product for Clinical Use supplied pursuant to this
Agreement shall bear such COGS price.

                 5.5.1.4 Reconciliation. From time to time, the Product
Coordinators shall meet and reconcile the operational definition of COGS against
the actual cost of goods sold. Unless otherwise agreed to in writing, any
amounts paid by Company in excess of the actual cost of goods sold may be (i)
credited against future purchases of Product for Clinical Use or future payments
to be made to Surgica pursuant to the applicable Surgica Budget or (ii) credited
against any royalty due Surgica, at the discretion of Company.

           5.5.2 Method of Payment. Unless otherwise provided for herein, all
payments due hereunder to Surgica shall be paid to Surgica not later than thirty
(30) days following the date of the applicable invoice.

           5.5.3 Records; Examination of Books. Surgica shall keep and maintain
adequate and compete records and books of account documenting all of its
expenses related to the respective Project Plans and Products provided to
Company hereunder. Company shall have the right, at its own expense, for any
period during which Company purchases Product hereunder and for three (3) years
thereafter, to have an independent public accountant, reasonably acceptable to
Surgica, examine the relevant financial books and records of account of Surgica
during normal business hours, upon reasonable notice, to determine or verify the
appropriate Fully-Burdened Cost of Product purchased hereunder. If an error of
two percent (2%) or more in Company's favor (i.e., if Surgica had overcharged
for the supplied Product in an amount equal to 2% or more of the actual
Fully-Burdened Cost of such Product) are discovered as a result of such
examination, the expense of such examination and the deficiency (including
interest on the delinquent amount of not less than one percent (1%) per month)
shall be credited against any royalty due Surgica. The opinion of such
independent public accountant shall be binding on the parties hereto with
respect to Fully-Burdened Cost hereunder.

[*****] Material is confidential and has been omitted and filed separately with
the Securities and Exchange Commission.

                                       10

      5.6  Production and Quality Control.
           ------------------------------

           5.6.1 Surgica warrants, represents and covenants that all Product
produced for or supplied to Company hereunder shall (a) be manufactured free
from defects in materials and workmanship; (b) with respect to Product for
Clinical Use, (i) meet the specifications in all applicable Regulatory Approvals
of all applicable Regulatory Agencies including, without limitation, compliance
with applicable ISO 13485 Standards, Council Directive Concerning Medical
Devices 93/42/EEC, and Quality Systems Regulations in effect at the time of
production and/or such other lawful and appropriate standards as the parties may
agree upon in writing. Each Party acknowledges that production specifications
may be modified from time to time to comply with applicable laws and
regulations.

           5.6.2 Surgica shall retain samples of all ingredients, packaging
materials, records and data as may be in accordance with the sample and record
retention policies which Surgica uses (or used) in connection with manufacture
of Product for its own account; provided such retention shall at all times be in
accordance with all applicable Regulatory Approvals, Quality System Regulations,
Council Directive Concerning Medical Devices 93/42/EEC, and ISO 13485 Standards.
Company shall have the right, no more frequently than once every six (6) months,
to review Surgica's manufacturing procedures and operations and its records
relating to the manufacture and shipment of Product. Additionally, Company may
from time to time audit Surgica's compliance with all applicable Regulatory
Approvals (including, without limitation, Quality System Regulations, Council
Directive Concerning Medical Devices 93/42/EEC, and ISO 13485). Surgica shall
notify Company in writing of any contemplated changes to, or modifications of,
its facilities, methods, processes, specifications, or other aspect of its
manufacturing operations that may have an impact on the efficacy or safety of
the Product and shall seek and, subject to Company's discretion, obtain
Company's written approval of such changes or modifications before implementing
the contemplated changes and/or modifications. No inspection or testing of
Product by Company, or failure to test or inspect, nor any audit, or failure to
audit, shall relieve Surgica of its obligations hereunder. Copies of all
certificates, reports, test results or other information produced by Surgica, or
by a third party consultant or contractor at Surgica's request, that directly
relate to lots of Product supplied to Company or its designee(s) shall, upon the
written request of Company, be furnished to Company and may be relied upon by
it.

      5.7  Title to Product. Surgica hereby covenants, represents and warrants
to Company that title to all Product supplied hereunder shall pass to Company
and all Company customers and subcontractors as provided herein (or in the
applicable Project Plan or Order) free and clear of any security interest, lien,
or other encumbrance.

      5.8  Post-Supply Obligations.

           5.8.1 Complaints. Company and Surgica shall develop a protocol for
exchanging information on product complaints concerning each of the Products of
which either Party becomes aware, so as to allow each of Company and Surgica to
comply with its respective regulatory obligations. At a minimum, such protocol
shall provide that if either Party receives a complaint or information regarding
a Product with respect to which would be required under applicable law to be
disclosed to a Regulatory Agency, it shall promptly, but in any event not

                                       11

later than seventy-two hours (72) hours after receipt, advise the other Party in
writing of the details of such complaint or information. Promptly thereafter,
Company shall report such complaint or information to the appropriate Regulatory
Agencies. The Party initially receiving the complaint or information shall
provide the other Party with all available follow-up information related to such
incident (including any information in such Party's possession as may be
reasonably required by the other Party to satisfy its regulatory filing
obligations). Surgica will provide Company with any information in its
possession that may facilitate prompt and favorable resolution of any customer
complaints pertaining to the Product.

           5.8.2 Recalls. Recalls shall be directed by Company in its sole
discretion. If Company, in its sole discretion , by order of a government or
government agency, or at the direction of Surgica, determines to recall any
Product, Company shall notify Surgica promptly by telephone or electronic mail
or telecopy. Company shall give Surgica reasonable opportunity to comment in
advance on any public announcement to be made by Company regarding any recall.
In the event any Product is recalled, Company shall assume complete
responsibility for conducting such recall; however, Surgica shall timely provide
Company with all information that may be in Surgica's possession or control
concerning the manufacture of the Product which Company reasonably may require
to conduct such recall. Company and Surgica shall fully cooperate with each
other to identify and correct deficiencies, if any, in the manufacture,
shipment, storage or distribution of Product.

6.    General Representations and Warranties; Disclaimer.

      6.1  Representations and Warranties. Each Party represents and warrants to
the other that:

           (i) this Agreement has been duly authorized, executed and delivered
and constitutes a valid and binding obligation of such Party, enforceable in
accordance with its terms;

           (ii) there are no outstanding agreements, assignments, claims or
encumbrances inconsistent with the provisions of this Agreement;

           (iii) it has the full power and right to grant the licenses,
sublicenses and rights herein and that it will obtain agreements with its
employees and consultants sufficient to allow it to provide the assignments
granted herein; and

           (iv) performance of all the terms of this Agreement shall not breach
any agreement entered into prior to the execution of this Agreement to keep
proprietary information acquired by it in confidence or in trust.

      6.2  Warranty Disclaimer. EXCEPT FOR SUCH REPRESENTATIONS AND WARRANTIES
AS ARE EXPRESSLY PROVIDED IN THIS AGREEMENT, NEITHER PARTY MAKES ANY OTHER
REPRESENTATIONS OR WARRANTIES, EXPRESS OR IMPLIED, INCLUDING, WITHOUT
LIMITATION, WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
NON-INFRINGEMENT WITH RESPECT TO ANY DEVELOPED PRODUCT, ANY LICENSE GRANTED
HEREIN OR SERVICES PERFORMED HEREUNDER.

                                       12

7.    Limited Liability.

      EXCEPT WITH RESPECT TO EACH PARTY'S INDEMNIFICATION AND CONFIDENTIALITY
OBLIGATIONS (SET FORTH IN SECTIONS 2.8, 9, 10 AND 14), NOTWITHSTANDING ANYTHING
ELSE IN THIS AGREEMENT OR OTHERWISE, NEITHER PARTY SHALL BE LIABLE OR OBLIGATED
UNDER ANY SECTION OF THIS AGREEMENT OR UNDER ANY CONTRACT, NEGLIGENCE, STRICT
LIABILITY OR OTHER LEGAL OR EQUITABLE THEORY FOR ANY SPECIAL, EXEMPLARY,
INDIRECT, INCIDENTAL OR CONSEQUENTIAL DAMAGES.

8.    Insurance.

      Company and Surgica shall, prior to commencement of activities involving
Clinical Use of Product, and at all times thereafter until twelve (12) months
after the expiration or termination of this Agreement, each carry such products
liability and comprehensive general liability insurance, premises and
operations, naming the other party as an insured under such policy, and in such
amounts and subject to such other requirements and restrictions as may be
customary in the United States; provided, however, that Surgica shall not be
required to carry product liability insurance during the period commencing on
the Effective Date and continuing until the earlier of (i) the Effective Date of
the Purchase Agreement pursuant to Company exercising the Option (as that term
is defined in the Option Agreement) and (ii) the expiration or earlier
termination of the Option Agreement. Surgica and Company shall have the right to
audit the other party to ensure compliance with this obligation. [*****] The
parties agree that any failure to comply with the obligations of this Section 8
shall be deemed a material breach of this Agreement.

9.    Indemnification.

      9.1  Company Indemnification. Company shall indemnify and hold harmless,
pursuant to the provisions of this Section 9, Surgica and each of its officers,
directors, employees, agents and Affiliates (collectively, the "Surgica
Indemnitees"), from and against, and will reimburse each such Surgica Indemnitee
with respect to, any and all Third Party claims, actions, demands, losses,
damages, liabilities, costs and expenses to which such Surgica Indemnitee may
become subject, including reasonable fees and disbursements of counsel and
expenses of reasonable investigation (collectively, "Surgica Losses"), arising
out of, based upon or caused by: (a) the inaccuracy of any representation or the
breach of any warranty, covenant or agreement of Company contained in this
Agreement, the License Agreement or the Option Agreement; (b) any failure by
Company to conduct its obligations arising hereunder in a diligent and
professional manner and in accordance with all applicable laws and regulations;
or (c) any gross negligence or intentional wrongdoing by Company in the
performance of its obligations (except in each case, and solely to the extent,
that any Surgica Loss is due to the gross negligence or willful misconduct of
one or more Surgica Indemnitees).

      9.2  Surgica Indemnification. Surgica shall indemnify and hold harmless,
pursuant to the provisions of this Section 9, Company and each of its officers,
directors, employees, agents

[*****] Material is confidential and has been omitted and filed separately with
the Securities and Exchange Commission.

                                       13

and Affiliates (collectively, the "Company Indemnitees"), from and against, and
will reimburse each such Company Indemnitee with respect to, any and all Third
Party claims, actions, demands, losses, damages, liabilities, costs and expenses
to which such Company Indemnitee may become subject, including reasonable fees
and disbursements of counsel and expenses of reasonable investigation
(collectively, "Company Losses"), arising out of, based upon or caused by: (a)
the inaccuracy of any representation or the breach of any warranty, covenant or
agreement of Surgica contained in this Agreement, the License Agreement or the
Option Agreement; (b) the manufacture or supply of Products; (c) any failure by
Surgica to conduct its obligations arising hereunder in a diligent and
professional manner and in accordance with all applicable laws and regulations;
(d) infringement by Surgica's Technology or Project Technology developed by
Surgica in connection with this Agreement or any Project Plan of any Patent
issued as of the date of delivery of such of Surgica's Technology or Project
Technology or any Copyright or Trademark or misappropriation of any trade
secret; or (e) any gross negligence or intentional wrongdoing by Surgica in the
performance of its obligations (except in each case, and solely to the extent,
that any Company Loss is due to the gross negligence or willful misconduct of
one or more Company Indemnitees); provided, however, that Surgica shall not be
obligated to indemnify the Company Indemnitees for claims arising out of any
Product's infringement of any intellectual property right of a Third Party
resulting from such Company Indemnitee's: (i) misuse or mishandling of Product
or (ii) unauthorized modification of Product.

      9.3  Indemnification Procedures. Each Party, on behalf of itself and its
respective Surgica Indemnitees or Company Indemnitees (each such Person, an
"Indemnitee"), agrees to provide the indemnifying Party prompt written notice of
any action, claim, demand, discovery of fact, proceeding or suit (collectively,
a "Claim") for which such Indemnitee intends to assert a right to
indemnification under this Agreement; provided, however, that failure to give
such notification shall not affect each applicable Indemnitee's entitlement to
indemnification (or the corresponding indemnifying Party's indemnification
obligations) hereunder except to the extent that the indemnifying Party shall
have been prejudiced as a result of such failure. The indemnifying Party shall
have the initial right (but not obligation) to defend, settle or otherwise
dispose of any Claim for which an Indemnitee intends to assert a right to
indemnification under this Agreement as contemplated in the preceding sentence
if, and for so long as, the indemnifying Party has recognized in a written
notice to the Indemnitee provided within thirty (30) days of such written notice
its obligation to indemnify the Indemnitee for any Surgica Losses or Company
Losses (as the case may be) relating to such Claim; provided, however, that if
the indemnifying Party assumes control of the defense, settlement or disposition
of a Claim, the indemnifying Party shall obtain the written consent of each
applicable Indemnitee prior to ceasing to defend, settling or otherwise
disposing of the Claim. If the indemnifying Party fails to state in a written
notice during such thirty (30) day period its willingness to assume the defense
of such a Claim, the Surgica Indemnitee(s) or Company Indemnitee(s), as the case
may be, shall have the right to defend, settle or otherwise dispose of such
Claim, subject to the applicable provides of Sections 9.1 and 9.2.

10.   Confidentiality.

      10.1 Subject to Section 10.3, during the term of this Agreement and for a
period of five (5) years thereafter (except with respect to trade secrets, for
which the obligations of non-use and non-disclosure shall continue for so long
as such trade secrets are protected by their owner as

                                       14

trade secrets), each Party shall maintain in confidence and shall not disclose
to any Third Party any know-how, trade secrets, business or technical
information or other information ("Confidential Information") received from the
other Party relating to any Product, and shall not use the other Party's
Confidential Information except for the purposes of this Agreement without the
prior written consent of such other Party. These confidentiality and non-use
obligations shall not apply to any Confidential Information that the receiving
Party can demonstrate:

           10.1.1 at the time of disclosure to the receiving Party was, or
thereafter becomes, a part of the public domain through no fault of the
receiving Party, its Affiliates, distributors or sublicensees;

           10.1.2 was subsequently lawfully disclosed to the receiving Party by
a Third Party not under an obligation of confidentiality with or through the
disclosing Party;

           10.1.3 was in the lawful possession of the receiving Party prior to
disclosure by the disclosing Party; or

           10.1.4 is required to be disclosed by judicial or administrative
order, provided that notice is given to the disclosing Party and the disclosing
Party has an opportunity, if reasonable under the circumstances, to seek a
protective order, and further provided, that disclosure is limited solely to
compliance with the judicial or administrative order.

      10.2 During the term of this Agreement, each Party shall take all
reasonable steps to:

           10.2.1 prevent any disclosure in breach of Section 10.1 of
Confidential Information of the other which would be materially prejudicial to
the interests of the other Party;

           10.2.2 limit the disclosure of information to such of its Affiliates,
distributors and sub-licensees and their respective employees that require the
information for the purposes of this Agreement; and

           10.2.3 ensure that the persons referred to in Section 10.2.2 enter
into appropriate confidentiality agreements containing use and disclosure
restrictions at least as restrictive as those set forth herein.

      10.3 Notwithstanding the foregoing provisions of this Section, the Parties
and their Affiliates, distributors and sublicensees shall be entitled to
disclose Confidential Information of the other Party which would otherwise be
protected by the provisions of Section 10.1 to actual or potential customers for
any Product in so far as such disclosure is reasonably necessary to
commercialize such Product.

      10.4 Equitable Relief. Each Party acknowledges and agrees that, due to the
unique nature of the other's Proprietary Information, there can be no adequate
remedy at law for any breach of its obligations hereunder and, therefore, that
upon any breach of Section 10.1 or threat thereof, the other Party shall be
entitled to injunctive relief and other appropriate equitable relief, without
the posting of any bond, in addition to whatever remedies it may have at law.

                                       15

11.   Non-Solicitation. During the term of this Agreement and for one (1) year
thereafter, neither Party shall, directly or indirectly, encourage, solicit or
participate in the solicitation of any employee or consultant of the other Party
to terminate such employee's or consultant's employment with such other Party;
provided, however, that such prohibition shall not apply to mass-media
advertisements directed toward the general public.

12.   Term and Termination.

      12.1 Term. The term of this Agreement shall commence as of the date hereof
and, unless terminated earlier pursuant to the provisions of this Agreement,
shall expire upon the expiration or termination of the License Agreement.

      12.2 Termination. The obligations of a Party under this Agreement (but not
its rights hereunder) may be terminated by such Party if, subject to Section 13
below, the other Party fails to perform any material term, provision, covenant
or obligation imposed upon it under this Agreement, which failure or refusal
shall continue for thirty (30) days following written notice thereof from the
non-defaulting party specifying the event of default.

           12.2.1 The failure of a Party to terminate its obligations under this
Agreement by reason of the breach of any of the provisions by the other Party
shall not be construed as a waiver of the rights or remedies available for any
subsequent breach of the terms and provisions of this Agreement.

           12.2.2 A Party electing to terminate its obligations under this
Agreement shall also be entitled to pursue such additional remedies at law or in
equity that it may have as a result of a breach of or default under this
Agreement by the other Party.

           12.2.3 Any Party bringing action to enforce the obligations of the
other Party or its rights under this Agreement shall be entitled to recover all
costs and expenses (including reasonable attorneys' fees and court costs)
incurred by it in such enforcement action.

      12.3 Effect of Termination. Upon termination of this Agreement by either
Party or naturally at the end of the term of this Agreement all rights and
licenses granted hereunder, except as otherwise expressly provided by the terms
hereof, shall terminate.

      12.4 Not Sole Remedy. Termination is not the sole remedy under this
Agreement and, whether or not termination is effected, all other remedies shall
remain available.

      12.5 Survival. Following expiration or termination of this Agreement,
Sections 3, 4.2, 5.4, 5.5, 5.6, 5.7, 6 through 12, 11 (for one (1) year only),
12.3, 12.5, 17, and 18, and such provisions of Section 1 as are necessary to
implement the surviving provisions shall remain in full force and effect in
accordance with their terms.

                                       16

13.   Force Majeure.

      13.1 Subject to compliance with paragraph (b) of this Section 13 any
delays in or failure of performance by either Party under this Agreement shall
not be considered a breach of this Agreement if and to the extent caused by any
occurrences beyond the reasonable control of the Party affected, including but
not limited to: acts of God; acts, regulations or laws of any government;
strikes or other concerted acts of workers; fires; floods; explosions; riots;
wars; rebellion; embargo; and sabotage; and any time for performance hereunder
shall be extended by the actual time of delay caused by such occurrence. The
Party suffering from a force majeure event shall take reasonable measures to
remove the disability or restriction and resume operations at the earliest
possible date.

      13.2 Any Party affected by such force majeure who wishes to rely on the
provisions of Section 13.1 shall as soon as reasonably practicable give written
notice to the other Party specifying the matters constituting force majeure
together with such evidence thereof as it can reasonably give and specifying the
period for which it is estimated that the such delay will continue.

14.   Relationship of the Parties. Notwithstanding any provision hereof, for all
purposes of this Agreement each Party shall be and act as an independent
contractor and not as partner, joint venturer, or agent of the other and shall
not bind nor attempt to bind the other to any contract. Each Party (the
"Responsible Party") shall indemnify and hold harmless the other Party (the
"Protected Party") from any and all claims, liabilities, damages, debts,
settlements, costs, attorneys' fees, expenses and liabilities of any type
whatsoever that may arise on account of the activities of the Responsible
Party's employees or agents, including, without limitation, providing
unauthorized representations or warranties (or failing effectively to disclaim
all warranties and liabilities on behalf of the Protected Party) to its
customers.

15.   Assignment. Surgica shall not assign or otherwise transfer this Agreement
or  any part hereof (and any attempt to do so will be void) to any Third Party
without the prior written permission of Company, except to an entity that
acquires all or substantially all of such Party's assets or operations. The
provisions of this Agreement shall inure to the benefit of, and be binding upon,
Company and Surgica and their respective successors and assigns.

16.   Publicity and Press Releases. Except to the extent necessary under
applicable laws, the Parties agree that no press releases or other publicity
relating to the substance of the matters contained herein will be made without
joint approval.

17.   Arbitration.

      17.1 Excepting only actions and claims relating to actions commenced by a
Third Party against Surgica or Company (including, without limitation, for
injuries caused by a Product or in respect to a trademark or patent infringement
claim), any controversy or claim arising out of or relating to the terms and
conditions of this Agreement, or the decision to agree upon these terms, or the
breach thereof, including questions of validity, infringement, or termination
hereof, shall be settled exclusively by arbitration in accordance with the rules
of the American Arbitration Association. If such controversy or claim relates to
patent validity or infringement, then the

                                       17

Patent Arbitration Rules of the American Arbitration Association ("AAA") shall
apply; otherwise the International Arbitration Rules of the AAA shall apply.
Notwithstanding the foregoing to the contrary or in the arbitration rules
invoked or in this Section 17, the Parties retain the right to request a
judicial authority to invoke interim measures of protection, and such request
shall not be deemed incompatible with this agreement to arbitrate or a waiver of
the right to arbitrate.

      17.2 There shall be one (1) arbitrator to be mutually agreed upon by the
Parties and to be selected from the Regional Panel of Distinguished Neutrals. If
the Parties are unable to agree upon such an arbitrator who is willing to serve
within ten (10) days of receipt of the demand by the other Party, the Parties
shall within three (3) days select one of the four largest international public
accounting firms (excluding those providing services to the Parties) and engage
the managing partner or senior officer of its County office located in the
county containing the principal place of business of the Party who did not
initiate the arbitration to designate a partner of such firm to serve as the
arbitrator. Failing that, then the AAA shall appoint an arbitrator willing to
serve from the Regional Panel of Distinguished Neutrals, or if no such panel
exists, then from an appropriate AAA panel. It shall be the duty of the
arbitrator to set dates for preparation and hearing of any dispute and to
expedite the resolution of such dispute.

      17.3 The arbitration shall be held in the city in which the principal
place of business of the Party who did not initiate the arbitration is located
and the arbitrator shall apply the substantive law of California except that the
interpretation and enforcement of this arbitration provision shall be governed
by the Federal Arbitration Act.

      17.4 The arbitrator shall permit and facilitate discovery, which will be
conducted in accordance with the Federal Rules of Civil Procedure, taking into
account the needs of the Parties and the desirability of making discovery
expeditious and cost-effective.

      17.5 The arbitrator will set a discovery schedule with which the Parties
will comply and attend depositions if requested by either Party.

      17.6 The arbitrator will entertain such presentation of sworn testimony or
evidence, written briefs and/or oral argument as the Parties may wish to
present, but no testimony or exhibits will be admissible unless the adverse
party was afforded an opportunity to examine such witness and to inspect and
copy such exhibits during the pre-hearing discovery phase.

      17.7 The arbitrator shall among his other powers and authorities, have the
power and authority to award interim or preliminary relief.

      17.8 The arbitrator shall not be empowered to award either Party exemplary
or punitive damages or any enhanced damages for willful infringement and the
Parties shall be deemed to have waived any right to such damages.

      17.9 A qualified court reporter will record and transcribe the proceeding.

      17.10 The decision of the arbitrator will be in writing and judgment upon
the award by the arbitrator may be entered in any court having jurisdiction
thereof.

                                       18

      17.11 Prompt handling and disposal of the issue is important. Accordingly,
the arbitrator is instructed to assume adequate managerial initiative and
control over discovery and other aspects of the proceeding to schedule discovery
and other activities for substantially continuous work, thereby expediting the
arbitration as much as is deemed reasonable to him, but in all events to effect
a final award no later than 365 days after the arbitrator's selection or
appointment and no later than 20 days after the close of evidence.

      17.12 The proceedings shall be confidential and the arbitrator shall issue
appropriate protective orders to safeguard both Parties' confidential
information.

      17.13 The fees of the arbitrator and the AAA shall be paid as designated
by the arbitrator or, if he shall not so designate, they shall be split equally
between the Parties.

18.   Miscellaneous.

      18.1 Entire Agreement. This Agreement (and all Exhibits hereto and Project
Plan(s) pursuant to this Agreement) constitutes the entire and only agreement
between the Parties relating to the subject matter hereof, and supersedes all
proposals, prior negotiations, representations, understandings and agreements
between the Parties relating to the subject matter of this Agreement and of past
dealings or industry custom.

      18.2 Notices.

           18.2.1 Notices hereunder shall be in writing and shall be deemed to
have been duly given if personally delivered or when sent by facsimile or other
telegraphic means. Such notices shall be effective upon receipt, if by personal
delivery, or if by facsimile, on the date of the confirmation of "ok"
transmission. Addresses and persons to be notified may be changed by either
Party by giving written notice thereof to the other Party.

           For Surgica:

                  Surgica Corporation
                  5090 Robert J. Mathews Parkway #4
                  El Dorado Hills, Ca 95762
                  Facsimile:  916.933.5260
                  Attention:  Louis R. Matson

                  with a copy to:

                  Bullivant Houser Bailey
                  1331 Garden Hwy, Suite 300
                  Sacramento, CA 95833
                  Facsimile:  916.442.3442
                  Email eric.stiff@bullivant.com
                  Attention:  Eric J. Stiff, Esq.

                                       19

           For Company:

                  Protein Polymer Technologies, Inc.
                  10655 Sorrento Valley Road
                  San Diego, CA  92121
                  Facsimile:  858.558.6477
                  Email:   wnp@ppti.com; jtp@ppti.com
                  Attention:  William N. Plamondon, Chief Executive Officer
                  and J. Thomas Parmeter, Chairman

                  with a copy to:

                  Paul, Hastings, Janofsky & Walker LLP
                  515 South Flower Street
                  Los Angeles, CA  90071-2228
                  Facsimile:  213.996.3254
                  Attention:  Robert A. Miller Jr., Esq.

      18.3 Governing Law and Legal Actions. This Agreement shall be governed by
and construed under the laws of the State of California and the United States,
without regard to the conflicts of laws provisions thereof. Subject to Section
17 above, the sole jurisdiction and venue for actions related to the subject
matter hereof shall be the Superior Court of the State of California for San
Diego County or the United States District Court for the Southern District of
California. Both Parties consent to the jurisdiction of such courts and agree
that process may be served in the manner provided herein for giving of notices
or otherwise as allowed by California state or U.S. federal law. In any action
or proceeding to enforce rights under this Agreement, the prevailing Party shall
be entitled to recover costs and attorneys' fees.

      18.4 Savings Provision. The invalidity of any provision of this Agreement
shall not impair the validity of any other provision; and any provision hereof
which might otherwise be invalid or contravene any applicable law shall hereby
be deemed to be amended to the extent necessary to remove the cause of such
invalidity and to the extent practicable to continue the intent of such
provision and of this Agreement, and such provision, as so amended, shall remain
in full force and effect as a part hereof.

      18.5 Amendments and Waivers. No terms or provisions of this Agreement
shall be varied or modified by any prior, contemporaneous or subsequent
statement, conduct or act of either of the Parties, whether oral or written,
except that the Parties may amend this Agreement by written instrument
specifically referring to this Agreement. No waiver of any right or remedy
hereunder shall be effective unless in a writing signed by the Party to be
bound, nor shall any waiver in one instance constitute a waiver of the same or
any other right or remedy in any other instance.

      18.6 Headings. Headings included herein are for convenience only and shall
not be used to interpret or construe this Agreement.

      18.7 Remedies; Injunctive Relief. The rights and remedies of a Party set
forth herein with respect to failure of the other Party to comply with the terms
of this Agreement are not

                                       20

exclusive, the exercise thereof shall not constitute an election of remedies and
the aggrieved Party shall in all events be entitled to seek whatever additional
remedies may be available in law or in equity (including, without limitation,
appropriate injunctive relief).

      18.8 Counterparts. This Agreement may be executed in counterparts and by
facsimile, each of which shall be deemed an original, and all of such
counterparts taken together shall constitute one and the same instrument.

                           [Signature page to follow]

                                       21

                                                                  EXECUTION COPY

         IN WITNESS WHEREOF, Company and Surgica have caused this Agreement to
be executed as of the date first written above.

PROTEIN POLYMER TECHNOLOGIES, INC.        SURGICA CORPORATION

By:/s/ William N. Plamondon, III          By:/s/ Louis R. Matson
   ------------------------------            -----------------------------------
       William N. Plamondon, III             Louis R. Matson
       Chief Executive Officer               Present and Chief Executive Officer

                [Signature Page to Supply and Services Agreement]

**EXHIBITA** **MANAGEMENTCOMMITTEE;PROJECTCOORDINATORS** [*****]                   [*****] Material is confidential and has been omitted and filed separately with the Securities and Exchange Commission. Ex.A - 1    **SCHEDULE 2.3** **PROJECTPLANNO. 1** [*****]                   [*****] Material is confidential and has been omitted and filed separately with the Securities and Exchange Commission.  Sc.2.3 - 3    
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