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EXHIBIT 10.9
 SUBLEASE AGREEMENT
 between
 AVANIR PHARMACEUTICALS
as Sublandlord
 and
 SIRION THERAPEUTICS, INC.
as Subtenant
 Building Address:
    
    11408 Sorrento Valley RoadSan Diego, California 92121




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SUBLEASE AGREEMENT
 Sublease th Effective Date Sublandlord Subtenant Parties Party
  Master Landlord Master Lease Exhibit A
 Master Lease Premises Center
   Summary and Definitions
 (a) Base Rent
 Period DuringSublease Term
    
    Monthly Base Rent
    
    Annual Base RentSublease Commencement Date through
and including the day immediately
preceding the first anniversary of
the Sublease Commencement Date
    
    $
    21,150.00
    
    
    $
    253,800.00First anniversary of Sublease
Commencement Date through and
including the day immediately
preceding the second anniversary
of the Sublease Commencement Date
    
    $
    21,784.50
    
    
    $
    261,414.00Second anniversary of Sublease
Commencement Date through and
including the day immediately
preceding the third anniversary of
the Sublease Commencement Date
    
    $
    22,438.00
    
    
    $
    269,256.42




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(b) Security Deposit
 (c) Sublease Premises Building Exhibit B
 (d) Term
 Sublease Term Sublease Commencement Date Sublease
Expiration Date Paragraph 15
 2




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Sublease
  Condition of Sublease Premises
   Base Rent
  3




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Additional Rent
 Paragraph 4 Additional Rent Subtenants
Rent
 Rent Payments
 Paragraph 17 Paragraph 20 Paragraph 7
  4




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Late Charges
  Use
  5




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Paragraph 8
 Contract Vivarium Services
  Operating Costs/Real Estate Taxes/Utilities
 Subtenants Pro Rata Share
 6




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Utilities
 Security Services
 7




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Subordination
  Incorporation of Master Lease Terms
 Paragraph 12
 8




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Paragraph 12
  Specific Section ExcludedSection
    
    Subject Matter
    
    (if not entire Section)Section 1
    
    Basic Lease TermsSection 2
    
    The PremisesSection 3
    
    Lease TermSection 4
    
    Rent
    
    Section 4.1 (Minimum Monthly Rent);
Section 4.2 (Lease Year); Section 4.4
(Impounds)Section 5
    
    Security Deposit
    
    Section 5.3 (Reduction of Security  Deposit Amount)Section 21
    
    Default by Tenant
    
    Section 21(d)(v)
   9




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provided however Paragraph
15
 10




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Sections
9.5 12.2 13 14.5
 Section 16 Section 17
 Section 16 Section 17
  11




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Insurance
 Section
9
 Surrender of Sublease Premises; Holding Over
   12




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Paragraph 14(c)
  Waiver and Indemnification
 Paragraph 12(d)(iv)
 Hazardous Materials
 Paragraph 16 Hazardous Materials
 13




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Notices
  If to Sublandlord:
    
    Avanir Pharmaceuticalswith a copy to:
    
    Heller Ehrman LLP4350 La Jolla Village Dr., 7th FloorSan Diego, California 92122Attention: Stephen FerruoloIf to Subtenant:
    
    Sirion Therapeutics, Inc.
 14




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Security Deposit
 Paragraph
1(a) Letter of Credit Draw Event Section 5.1
 Assignment and Subletting
 Section 18 Paragraph 19
 15




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Permitted
Transfer
 Interest on Subtenants Obligations
  Authority
  Signage and Access
  Captions
  Successors and Assigns
  16




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Parking
  Master Landlord Consent
  Financial Statements
  Furniture, Fixtures and Equipment
 Exhibit C Exhibit C
 Direct Lease
  17




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Miscellaneous
          18




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19




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SUBLANDLORD:
AVANIR PHARMACEUTICAL
a California corporationBy:
    /c/ Michael J. PuntorieroName:
    Michael J. PuntorieroTitle:
    Senior VP of Finance & Chief Financial Officer SUBTENANT:
SIRION THERAPEUTICS, INC.,
a North Carolina corporationBy:
    /c/ Dawn E. Bennett JohnsonName:
    Dawn E. Bennett JohnsonTitle:
    Chief Financial Officer 20




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EXHIBIT A
 MASTER LEASE




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EXHIBIT B
 FLOOR PLAN OF SUBLEASE PREMISES




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EXHIBIT C
 FURNITURE, FIXTURES AND EQUIPMENT
 11408 Sorrento Valley Rd.




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