SECOND
AMENDMENT TO SECURITIES PURCHASE AGREEMENT


 


This
SECOND AMENDMENT TO SECURITIES PURCHASE AGREEMENT (this “Amendment”), dated as of February __, 2018, is by
and among Hancock Jaffe Laboratories, Inc., a Delaware corporation (the “Company”), and the undersigned signatories
hereto (collectively, the “Lenders”), and further amends that certain Securities Purchase Agreement, dated
as of June 15, 2017, as amended on December 29, 2017, by and among the Company and the signatories thereto (the “Purchasers”
and altogether, the “Purchase Agreement”), the Amended and Restated Convertible Notes issued pursuant to the
Purchase Agreement (the “2017 Notes”), and the Amended and Restated Common Stock Purchase Warrants issued pursuant
to the Purchase Agreement (the “2017 Warrants” and, together with the Purchase Agreement and the 2017 Notes,
the “Transaction Documents”). Capitalized terms used but not defined herein shall have the meaning ascribed
to such terms in the Transaction Documents.


 


RECITALS


 


WHEREAS,
the Company and the Lenders desire to amend the Transaction Documents to (i) extend the maturity date of the 2017 Notes to May
15, 2018, and (ii) provide that the number of Warrant Shares exercisable under the 2017 Warrants shall equal 100% of the number
of shares of Common Stock issuable upon conversion of the 2017 Notes;


 


WHEREAS,
pursuant to Section 5.5 of the Purchase Agreement, the Transaction Documents may be amended or the respective terms waived with
the written consent of the Company and the Purchasers holding a majority of the aggregate principal amount of all 2017 Notes issued
under the Purchase Agreement (the “Requisite Holders”); and


 


WHEREAS,
the Company and the undersigned Lenders, constituting the Requisite Holders, desire to amend the Transaction Documents as hereinafter
set forth.


 


AGREEMENT


 


NOW,
THEREFORE, for good and valuable consideration the receipt and sufficiency of which are hereby acknowledged and agreed, the parties
hereby agree as follows:


 


1.
Amendment to Purchase Agreement Section 2.2(a)(iii). Section 2.2(a)(iii) of the Purchase Agreement is hereby amended
and restated in its entirety as follows:


 


“(iii)
a Warrant registered in the name of such Purchaser with an exercise price per share equal to the lesser of (a) $14.40 or (b) 120%
of the Conversion Price, and to purchase up to a number of Common Shares equal to 100% of the number of Common Shares issuable
upon conversion of such Purchaser’s Note.”


 


2.
Amended and Restated Note. In connection and to facilitate the stated intent of the Company and the Lenders in the
recitals, among other things, the parties consent and agree that the 2017 Notes issued to all Purchasers are hereby further amended
and restated, substantially in the form attached hereto as Exhibit A (the “Second Amended and Restated Note”).
The Company shall execute and deliver the Second Amended and Restated Note to each Purchaser.


 




    	 	 	 



    	 



    

 


3.
Amended and Restated Warrant. In connection and to facilitate the stated intent of the Company and the Lenders in the
recitals, among other things, the parties consent and agree that the 2017 Warrants issued to all Purchasers are further hereby
amended and restated substantially in the form attached hereto as Exhibit B (the “Second Amended and Restated
Warrant”). The Company shall execute and deliver the Second Amended and Restated Warrant to each Purchaser.


 


4.
No Other Amendments. Except as herein amended, all provisions of the Transaction Documents shall remain in full force
and effect.


 


5.
Governing Law. This Amendment shall be governed by and construed in accordance with the internal laws of the State
of Delaware without giving effect to any choice or conflict of law provision or rule (whether of the State of Delaware or any
other jurisdiction) that would cause the application of laws of any jurisdiction other than those of the State of Delaware.


 


6.
Enforceability. If any provision of this Amendment is held invalid or unenforceable by any court of competent jurisdiction,
the other provisions of this Amendment will remain in full force and effect. Any provision of this Amendment held invalid or unenforceable
only in part or degree will remain in full force and effect to the extent not held invalid or unenforceable.


 


7.
Counterparts. This Amendment may be executed in one or more counterparts, each of which shall have the same force and
effect of the original.


 


[Signature
Page Follows]





 




    	 	 	 



    	 



    

 


IN
WITNESS WHEREOF, the parties hereto have caused this Amendment to be executed as of the date first above written.


 


	 	COMPANY:
	 	 	 
	 	HANCOCK
    JAFFE LABORATORIES, INC.
	 	 	 
	 	By:	 
	 	Name:	William
    R. Abbott            
	 	Title:	Chief
    Financial Officer


 


Signature
Page to Second Amendment to Securities Purchase Agreement





 




    	 	 	 



    	 



    

 


IN
WITNESS WHEREOF, the parties hereto have caused this Amendment to be executed as of the date first above written.


 


	 	LENDER:
	 	 	 
	 	By:	 
	 	Name:	           
	 	Title:	 


 


Signature
Page to Second Amendment to Securities Purchase Agreement


 







    	 	 	 



    	 



    

 


EXHIBIT
A


 


Second
Amended and Restated Note


 




    	 	 	 



    	 



    

 


EXHIBIT
B


 


Second
Amended and Restated Warrant