Amended and Restated Registration Rights Agreement



 Exhibit 10.1 
 SYNAGEVA BIOPHARMA CORP. 
 AMENDED AND RESTATED 

INFORMATION AND REGISTRATION RIGHTS AGREEMENT 
 April 1, 2009 
 Amended September 25, 2009 

Amended March 15, 2011 
 Amended November 2, 2011 







 TABLE OF CONTENTS 
  

											
	 	    	 	    	 	    	 	  	Page	 
			
	1.	    	 Certain Definitions
	  	 	5	  
			
	2.	    	 Financial Statements and Reports to Stockholders
	  	 	7	  
				
		    	2.1	    	 Financial Statements and Reports to Holders and SBIC Investors
	  	 	7	  
		    	2.2	    	 Covenants of the Company
	  	 	8	  
			
	3.	    	 SBIC Investors’ Inspection Rights
	  	 	11	  
			
	4.	    	 Right of First Refusal on New Securities
	  	 	11	  
				
		    	4.1	    	 Investor Right of First Refusal
	  	 	11	  
		    	4.2	    	 General Conditions
	  	 	11	  
			
	5.	    	 Termination of Covenants
	  	 	13	  
			
	6.	    	 Demand Registration
	  	 	13	  
				
		    	6.1	    	 Request for Registration on Form Other Than Form S-3
	  	 	13	  
		    	6.2	    	 Right of Deferral of Registration
	  	 	14	  
		    	6.3	    	 Limitations on Required Registration
	  	 	14	  
		    	6.4	    	 Registration of Other Securities in Demand Registration
	  	 	15	  
		    	6.5	    	 Underwriting in Demand Registration
	  	 	15	  
					
		    		    	6.5.1	    	 Notice of Underwriting
	  	 	15	  
		    		    	6.5.2	    	 Inclusion of Other Holders in Demand Registration
	  	 	15	  
		    		    	6.5.3	    	 Selection of Underwriter in Demand Registration
	  	 	15	  
		    		    	6.5.4	    	 Marketing Limitation in Demand Registration
	  	 	15	  
		    		    	6.5.5	    	 Right of Withdrawal in Demand Registration
	  	 	16	  
				
		    	6.6	    	 Blue Sky in Demand Registration
	  	 	16	  
			
	7.	    	 Piggyback Registration
	  	 	16	  
				
		    	7.1	    	 Notice of Piggyback Registration and Inclusion of Registrable Securities
	  	 	16	  
		    	7.2	    	 Underwriting in Piggyback Registration
	  	 	16	  
					
		    		    	7.2.1	    	 Notice of Underwriting in Piggyback Registration
	  	 	16	  
		    		    	7.2.2	    	 Marketing Limitation in Piggyback Registration
	  	 	17	  
		    		    	7.2.3	    	 Allocation of Shares in Piggyback Registration
	  	 	17	  


  
 -2-










											
		    		    	7.2.4	    	 Withdrawal in Piggyback Registration
	  	 	17	  
				
		    	7.3	    	 Blue Sky in Piggyback Registration
	  	 	18	  
			
	8.	    	 Expenses of Registration
	  	 	18	  
			
	9.	    	 Reports Under Exchange Act
	  	 	18	  
			
	10.	    	 Termination of Registration Rights
	  	 	19	  
			
	11.	    	 Registration Procedures and Obligations
	  	 	19	  
			
	12.	    	 Information Furnished by Holder
	  	 	21	  
			
	13.	    	 Indemnification
	  	 	21	  
				
		    	13.1	    	 Company’s Indemnification of Holders
	  	 	21	  
		    	13.2	    	 Holder’s Indemnification of Company
	  	 	21	  
		    	13.3	    	 Indemnification Procedure
	  	 	22	  
		    	13.4	    	 Contribution
	  	 	22	  
		    	 13.5
	    	 Conflicts
	  	 	23	  
		    	13.6	    	 Survival
	  	 	23	  
			
	14.	    	 Limitations on Registration Rights Granted to Other Securities
	  	 	23	  
			
	15.	    	 Transfer of Rights
	  	 	23	  
			
	16.	    	 Market Stand-off
	  	 	24	  
			
	17.	    	 No-Action Letter or Opinion of Counsel in Lieu of Registration
	  	 	25	  
			
	18.	    	 Miscellaneous
	  	 	25	  
				
		    	18.1	    	 Governing Law
	  	 	25	  
		    	18.2	    	 Counterparts
	  	 	25	  
		    	18.3	    	 Headings
	  	 	25	  
		    	18.4	    	 Notices
	  	 	25	  
		    	18.5	    	 Amendment of Agreement
	  	 	26	  
		    	18.6	    	 Severability
	  	 	26	  
		    	18.7	    	 Delays or Omissions
	  	 	26	  
		    	18.8	    	 Entire Agreement; Successors and Assigns
	  	 	26	  
		    	18.9	    	 Merger with Trimeris, Inc.
	  	 	26	  


  
 -3-









 AMENDED AND RESTATED 

INFORMATION AND REGISTRATION RIGHTS AGREEMENT 
 THIS AMENDED AND RESTATED INFORMATION AND REGISTRATION RIGHTS AGREEMENT (this “Agreement”) is made as of April 1, 2009 by and among SYNAGEVA BIOPHARMA CORP., a Delaware corporation
(the “Company”), and the persons listed on the attached Schedule 1.1 who are signatories to this Agreement (collectively, the “Investors”). 
 RECITALS 
 A. The Company and certain of the Investors have entered into a
certain agreement for sale by the Company and purchase by certain of the Investors of the Company’s Series D-:2 Preferred Stock (the “Series D-2 Holders”), and the Company desires to grant to the Series D•2 Holders a right
of first refusal on future financings, rights to certain information and registration rights pursuant to this Agreement. 
 B.
Pursuant to that certain 2007 Amended and Restated Information and Registration Rights Agreement dated September 28, 2007 (the “First Prior Agreement”) by and among the Company and holders of the Company’s Preferred Stock,
the Company granted the holders of Preferred Stock a right of first refusal in future financings, rights to certain information and registration rights related to the Company’s Preferred Stock. 

C. In accordance with the First Prior Agreement, which provided that the First Prior Agreement may be amended only by Holders (as
hereinafter defined) of 70% or more of the then outstanding “Registrable Securities” (as defined in the First Prior Agreement) consent to any amendment to the First Prior Agreement, the Company and the Investors amended and restated the
First Prior Agreement in its entirety on April 1, 2009 (as amended and restated, the “Second Prior Agreement”) to provide the holders of Preferred Stock, including holders of Series D-2 Preferred Stock, with the right of first refusal
in future financings, rights to certain information and registration rights as set forth herein. 
 D. Section 18.5 of the
Second Prior Agreement requires that persons holding at least 70% or more of the then outstanding “Registrable Securities” (as defined in the Second Prior Agreement) consent to any amendment to the Second Prior Agreement. 

E. The Company and certain of the Investors holding at least 70% of the “Registrable Securities” (as defined in the Second
Prior Agreement) entered into a Letter Agreement on September 25, 2009 (the “Letter Agreement”), amending the terms of the Second Prior Agreement. 
 F. The Company and the Investors desire to include the terms of the Letter Agreement in this Agreement as set forth herein, thereby amending the Second Prior Agreement. 

  
 -4-









 THE PARTIES AGREE AS FOLLOWS: 

1. Certain Definitions. 
 As used in this Agreement, the following terms shall have the following respective meanings: 
 (a) “Commission” shall mean the Securities and Exchange Commission or any other federal agency at the time of Registration administering the Securities Act. 

(b) “Convertible Securities” shall mean outstanding securities of the Company convertible into or exchangeable for
Common Stock of the Company or into other securities that are convertible into or exchangeable for Common Stock, including but not limited to the shares of the Company’s Series D-2 Preferred Stock, Series C-2 Preferred Stock, Series B¬2
Preferred Stock and Series A-2 Preferred Stock, held by the Investors. 
 (c) “Exchange Act” shall mean the
Securities Exchange Act of 1934, as amended, or any similar federal statute, and the rules and regulations of the Commission thereunder, all as the same shall be in effect at the time. 

(d) “Holder” shall mean any holder of outstanding Registrable Securities which have not been sold to the public, but
only if such holder is one of the Investors or an assignee or transferee of Registration rights as permitted by Section 15. 
 (e) “Initiating Holders” shall mean Holders who in the aggregate hold at least 20% of the Registrable Securities then held by all Holders of Registrable Securities, or a lesser number of
Registrable Securities sufficient to comprise a reasonably anticipated aggregate offering price to the public exceeding $7,000,000. 
 (f) “Long-Form Registration Statement” shall mean a registration statement on Form 5-1, Form S-2, Form SB-1 or Form SB-2, or any similar form of registration statement adopted by the
Commission from and after the date hereof 
 (g) “Major Investors” shall mean every Holder that holds 60,000
(together with its affiliates) or more Registrable Securities. 
 (h) “Material Adverse Event” shall mean an
occurrence or disclosure having a consequence that either (a) is materially adverse as to the business, properties or financial condition of the Company or (b) is reasonably foreseeable, has a reasonable likelihood of occurring, and if it
were to occur might materially adversely affect the business, properties or financial condition of the Company. 
 (i) The terms
“Register”, “Registered”, and “Registration” refer to a registration effected by preparing and filing a registration statement in compliance with the Securities Act (“Registration
Statement”), and the declaration or ordering of the effectiveness of such Registration Statement. 

  
 -5-









 (j) “Registrable Securities” shall mean all Common Stock not previously
sold to the public and issued or issuable upon conversion or exercise of any of the Company’s Convertible Securities purchased by or issued to the Investors or held by Holders, including Common Stock issued pursuant to stock splits, stock
dividends and similar distributions, and any securities of the Company granted registration rights pursuant to Section 15 of this Agreement. 
 (k) “Registration Expenses” shall mean all expenses incurred by the Company in complying with Sections 6 through 9 of this Agreement, including, without limitation, all federal and state
registration, qualification, and filing fees, printing expenses, fees and disbursements of counsel for the Company and one special counsel for Holders (if different from the Company), blue sky fees and expenses, and the expense of any special audits
incident to or required by any such registration. 
 (1) “Related Transaction” shall mean any transaction,
whether direct or indirect, with the Company where any current or former shareholder, director, officer or employee of the Company or any relative or “associate” (as defined in the rules and regulations promulgated under the Securities
Exchange Act of 1934, as amended) of any such person provides services (other than employment of such individuals by the Company) by or to, or the sale of products by or to, or rental of real or personal property from or to or transfer or license
technology, intellectual property or know-how (except for assignment of such to the Company in connection with employment or consultancy relationships with the Company), or otherwise requiring cash payments to or by, any such person in excess of an
aggregate of $1,000, other than the employment of such individuals, options granted to or exercised by such individuals pursuant to the Company’s 1996 Stock Option Plan or 2005 Stock Option Plan and purchases of securities of the Company by
such individuals on the same terms as other third party investors and other than a Participation Plan as may be adopted by the Board of Directors. 
 (m) “SBA” shall mean the United States Small Business Administration. 
 (n) “SBIC Act” shall mean the Small Business Investment Act of 1958, as amended. 
 (o) “SBIC Investors” shall mean TD Javelin Capital Fund II, L.P., a Delaware limited partnership, and TD Lighthouse Capital Fund, L.P., a Delaware limited partnership, each of which is a
small business investment company licensed by the SBA, and their successors and assigns. 
 (p) “Securities
Act” shall mean the Securities Act of 1933, as amended, or any similar federal statute, and the rules and regulations of the Commission thereunder, all as the same shall be in effect at the time. 

(q) “Selling Expenses” shall mean all underwriting discounts and selling commissions applicable to the sale of
Registrable Securities pursuant to this Agreement. 
 (r) “Series D-2 Purchase Agreement” shall mean that
certain Series D-2 Preferred Stock Purchase Agreement by and among the Company and the Investors identified therein, dated as of April 1, 2009. 

  
 -6-









 (s) “Short-Form Registration Statement” shall mean a registration statement
on Form S-3 or any similar form of registration statement adopted by the Commission from and after the date hereof. 
 (t)
“Qualified IPO” shall mean a firm commitment underwritten public offering of shares of Common Stock of the Company at a per share price not less than $7.00 per share (as appropriately adjusted for stock splits, dividends,
reclassifications, etc.) and for total net proceeds (after deduction of Selling Expenses) of at least $50 million. 
 (u)
“Tax” or “Taxes” means (A) any and all federal, state, provincial, local, foreign and other taxes, levies, fees, imposts, duties, and similar governmental charges (including any interest, fines, assessments,
penalties or additions to tax imposed in connection therewith or with respect thereto) including, without limitation (x) taxes imposed on, or measured by, income, franchise, profits or gross receipts, and (y) ad valorem, value added,
capital gains, sales, goods and services, use, real or personal property, capital stock, license, branch, payroll, estimated withholding, employment, social security (or similar), unemployment, compensation, utility, severance, production, excise,
stamp, occupation, premium, windfall profits, transfer and gains taxes, and customs duties, and (B) any transferee liability in respect of any items described in (A) above. 

2. Financial Statements and Reports to Stockholders. 

2.1 Financial Statements and Reports to Holders and SBIC Investors. 

The Company will furnish or cause to be furnished to the Major Investors and SBIC Investors: 

(a) Monthly Reports. Within thirty (30) days after the end of each month, monthly financial statements (including a balance sheet
and a statement of operations for the month and year-to-date, each in comparative form with the previous month); all prepared in accordance with GAAP consistently applied, with management’s analysis of results and a statement of the Chief
Financial Officer explaining any material differences from budget. The foregoing financial statements shall be certified by the Chief Executive Officer or Chief Financial Officer of the Company to the effect that such statements fairly present the
financial position and financial results of the Company for the fiscal period covered. “GAAP” shall mean United States generally accepted accounting principles. 
 (b) Annual Financial Statements. Within ninety (90) days after the end of each fiscal year of the Company (i) the consolidated and consolidating balance sheets of the Company as at the end of
such year, and (ii) the related consolidated and consolidating statements of income, retained earnings and cash flows for such year, setting forth in comparative form with respect to such consolidated financial statements figures for the
previous fiscal year, all in reasonable detail, together with the opinion thereon of the Company’s independent certified public accountants, which opinion shall state that such financial statements have been prepared in accordance with GAAP
applied on a basis consistent with that of the preceding fiscal year (except for changes, if any, which shall be specified and approved in such opinion) and that the audit by such accountants in connection with such financial statements has been
made in 

  
 -7-









 
accordance with generally accepted auditing standards related to reporting. Notwithstanding the above, if circumstances merit and at the election of the Board of Directors, the annual audit and
rendering of the opinion by the Company’s independent certified public accountants may be extended for a period not to exceed two hundred seventy (270) days. 
 (c) Budget and Operating Forecast. For each fiscal year of the Company, at least 30 days prior to the beginning of each fiscal year, a business plan, projections and monthly budget for the coming year,
together with a capital expenditures budget, approved by the Company’s Board of Directors; and such budget shall be accepted as the Company’s budget for such fiscal year when it has been approved by a majority vote of the Board of
Directors. The approved budget shall be reviewed by the Company periodically and all necessary changes or revisions to such budget shall be resubmitted to the Board of Directors and shall be accepted when approved in accordance with, and the Company
shall not make any such changes to the budget without such approval in accordance with, the majority of the Board of Directors. 

(d) Other Information for SBIC Investors. Promptly, from time to time, such other information regarding the business, prospects,
financial condition, operations, property or affairs of the Company as the SBIC Investors reasonably may request including any information required for SBA Form 468 and any other information reasonably requested or required by any governmental
agency asserting jurisdiction over the SBIC Investors for the sole purpose of verifying the Company’s continued eligibility as a small business concern. 
 (e) Information Covenant for SBIC Investors. Within sixty (60) days after the end of the fiscal year of the Company, the Company will furnish or cause to be furnished to the SBIC Investors
information required by the SBA concerning the economic impact of the SBIC Investors investment, for (or as of the end of) each fiscal year, including but not limited to, information concerning full-time equivalent employees; Federal, state and
local income taxes paid, gross revenue; source of revenue growth; after-tax profit or loss; and Federal, state and local income tax withholding. Such information shall be forwarded by Company on a form provided by the SBIC Investors. The Company
also will furnish or cause to be furnished to the SBIC Investors such other information regarding the business, affairs and condition of the Company as the SBIC Investors may from time to time reasonably request for the sole purpose of verifying the
Company’s continued eligibility as a small business concern. 
 This right to receive information as provided in this Section 2.1 is
in addition to any other right provided under the Bylaws of the Company or pursuant to applicable law. 
 2.2 Covenants of
the Company. 
 (a) Board Meetings. The Company shall reimburse all reasonable and documented expenses actually incurred by
the members of the Board of Directors designated or elected by the Holders in connection with their attendance at the meetings of the Board of Directors and its committees, and other meetings and events attended by such Board members on behalf of
the Company or at the Company’s request. 
 (b) Confidential Information and Inventions Agreement. Unless otherwise
determined by the Board of Directors, the Company shall require all future officers, employees 

  
 -8-









 
and consultants of the Company to execute and deliver a Employee Confidential Information and Inventions Agreement in substantially the form of Exhibit 5.9 to the Series D-2 Purchase Agreement.

 (c) Stock Plans. The Company may sell shares of stock and grant options to employees, advisors, officers, and directors of,
and consultants to, the Company only pursuant to such arrangements, contracts, or plans as are recommended by management and approved by the Board of Directors. 
 (d) Use of Proceeds. The Company certifies that it will use the proceeds from the Investors for the purposes and in the amounts set forth in Section 7.2 of the Series D-2 Purchase Agreement. The
Company will deliver to the SBIC Investors from time to time promptly following the SBIC Investors request, a written report, certified as correct by the Company’s Chief Executive Officer or Chief Financial Officer, verifying the purposes and
amounts for which proceeds from the sale of shares of the Company’s Convertible Securities have been disbursed. The Company will supply to the SBIC Investors and Major Investors such additional information and documents as the SBIC Investors
and Major Investors reasonably request with respect to its use of proceeds and will permit the SBIC Investors and Major Investors to have access to any and all Company records and information and personnel as the SBIC Investors and Major Investors
deem necessary to verify how such proceeds have been or are being used, and to assure that the proceeds have been used for the purposes specified on Section 7.2 of the Series D-2 Purchase Agreement. 

(e) SBIC Permitted Activities and Proceeds. So long as any SBIC Investor is a holder of Registrable Securities, or until the SBIC
Investor waives its rights under this Section 2.2(e): 
 (i) Neither the Company nor any of its affiliates will engage in
any activities or use directly or indirectly the proceeds from the sale of the Registrable Securities for any purpose for which a small business investment company is prohibited from providing funds by the SBIC Act, including 13 C.F.R. §107.
The general categories are (A) relenders or reinvestors, (B) passive businesses, (C) real estate businesses, (D) project financing, and (E) foreign investment. 

(ii) Without obtaining the prior written approval of the SBIC Investors, the Company will not change within one (1) year of the
date of this Agreement the Company’s business activity to a business activity which a small business investment company is prohibited from providing funds by the SBIC Act. The Company agrees that any such changes in its business activity
without such prior written consent of the SBIC Investors will constitute a material breach of the obligations of the Company under this Agreement (an “Activity Event of De fault”). If an Activity Event of Default occurs, the SBIC Investors
have the right to demand immediate repayment of the securities evidencing the sale of the Registrable Securities, together with interest on the aggregate amount invested from the date of the sale of the Registrable Securities to the date of
repayment, and the Company will immediately make such payment within thirty (30) days of receipt of a demand. The payment remedy is in lieu of any and all other rights and remedies against the Company and others to which the SBIC Investors may
be entitled. 

  
 -9-









 (f) Management Rights. The SBIC Investors and Major Investors shall be entitled to consult
with and advise management of the Company on significant business issues, including management’s proposed annual operating plans, and upon request management will meet with the SBIC Investors and Major Investors regularly during each year at
the Company’s facilities at mutually agreeable times for such consultation and advice and to review progress in achieving said plans. 
 (g) Press Releases. The Company agrees to give the SBIC Investors advanced notice of, and to consult with the SBIC Investors concerning the content of, any public announcements that the Company intends to
make. 
 (h) Taxes. The Company shall pay all Taxes imposed upon it or its income or profits or in respect of its property,
before the same shall become in default; provided, however, that the Company shall not be required to pay and discharge or to cause to be paid and discharged any such Taxes so long as the validity or amount thereof shall be contested in good faith
by appropriate proceedings. The Company, shall set aside on its books such reserves as are required by GAAP with respect to any such Taxes. 
 (i) System of Accounting. The Company shall maintain a system of 
 accounting established and
administered in accordance with GAAP, and shall set aside on its books all such proper reserves as shall be required by GAAP consistently applied. 
 (j) Loans and Investments. The Company will not make any loan or advance (other than advances in the ordinary course of business consistent with past practice with regard to valid business expenses) or
extend credit to any person or entity (other than trade credit in the ordinary course consistent with past practice), or make any investment in such person or entity, or its securities, except (A) investments in United States Treasury
obligations, (B) certificates of deposit, bankers acceptances and other “money market instruments” (excluding auction rate securities) issued by any bank or trust company organized under the laws of the United States or any state
thereof and having capital and surplus not less than $100,000,000, (C) open market commercial paper bearing, Standard & Poor’s highest credit rating or by another similar nationally recognized firm, and repurchase agreements with
any bank or trust company organized under the laws of the United States or any state thereof and having capital and surplus not less than $100,000,000 relating to United States government obligations, in each case maturing in less than one year, and
(D) investments in mutual funds registered under the Investment Company Act of 1940, which have net assets of at least $200,000,000 and at least 85% of whose assets consist of obligations having an investment grade credit grading from either
Standard & Poor’s Company or Moody’s Investors Service, Inc. and/or equity securities of entities that have obligations with such credit ratings. 
 (k) Related Transaction. The Company shall not, directly or indirectly, enter into any Related Transaction other than on an arm’s length basis, on terms no less favorable to the Company than could be
obtained from non-related persons and with the prior approval of the Board of Directors. 

  
 -10-









 (1) Regulatory Compliance Cooperation for SBIC Investors. The Company agrees that the SBIC
Investors and any SBA examiner shall have the rights of access and information specified in 13 C.F.R. §107.620 (and any successor provision). 
 3. SBIC Investors’ Inspection Rights. 
 The Company will permit
the SBIC Investors or their representatives, at the SBIC Investors expense, and examiners of the SBA to visit and inspect the properties and assets of the Company, to examine its books of account and records, and to discuss the Company’s
affairs, finances and accounts with the Company’s officers, senior management and accountants, all at such reasonable times as may be requested by the SBIC Investors or the SBA for the sole purpose of verifying the Company’s continued
eligibility as a small business concern. The SBIC Investors shall maintain the confidentiality of any confidential and proprietary information so obtained by them which is not otherwise available from other sources that are free from similar
restrictions; provided, however, that the foregoing, shall in no way limit or otherwise restrict the ability of the SBIC Investors or their authorized representatives to disclose any such information concerning the Company which they may be required
to disclose (a) to their partners, board members or stockholders, to the extent required to satisfy their fiduciary obligations to such persons, or (b) otherwise pursuant to or as required by law. 

4. Right of First Refusal on New Securities. 
 4.1 Investor Right of First Refusal. 
 The Company hereby grants to each
Holder that is at the applicable time an “accredited investor” within the meaning of Rule 501 promulgated by the Commission (each individually, a “Rightholder,” and collectively, the “Rightholders”) (assuming at the
applicable time that offers and sales of New Securities are being made only to “accredited investors”) the right of first refusal to purchase its pro rata share of New Securities (as defined in Section 4.2) that the Company may from
time to time propose to sell and issue after the date of this Agreement. For the issuance of New Securities, such Rightholder’s pro rata share is the ratio of the number of shares of capital stock of the Company owned by the Rightholder
(assuming conversion or exchange into Common Stock of all Convertible Securities) immediately prior to the issuance of the New Securities to the total number of shares of capital stock of the Company then outstanding (assuming conversion or exchange
into Common Stock of all Convertible Securities). 
 4.2 General Conditions. 

The above rights of first refusal shall be subject to the following provisions: 

(a) “New Securities” shall mean any Common Stock or Preferred Stock of the Company, whether now authorized or not, and
rights, options, or warrants to purchase any Common Stock or Preferred Stock of the Company and debt or equity securities of any type whatsoever that are, or may become, convertible into or exchangeable for Common Stock or Preferred Stock;
provided, however, that “New Securities” does not include (i) securities offered to the public in a firmly underwritten offering pursuant to a registration statement filed under the Securities Act; (ii) securities
issued pursuant to the acquisition of another entity by the Company 

  
 -11-









 
by merger, purchase of substantially all of the assets, or other reorganization (except as a vehicle for investing funds or conducting a financing); (iii) shares of the Company’s Common
Stock (or related options) issued to officers, directors, employees or consultants of the Company pursuant to any stock offering, plan or arrangement approved by the Board of Directors; (iv) securities issued in connection with any stock split,
stock dividend or recapitalization by the Company affecting all classes and series of Common Stock and Preferred Stock proportionately; (v) securities issued in connection with equipment leasing transactions approved by the Company’s Board
of Directors, including the directors elected by the Series D-2 Holders; (vi) securities issued to the Series D-2 Holders pursuant to the Series D-2 Purchase Agreement dated on or about the date hereof; (vii) Common Stock or Preferred
Stock issued upon the conversion, exercise or exchange of any securities issued pursuant to the Series D-2 Purchase Agreement or prior to the date hereof and disclosed in the Schedules to the Series D•2 Purchase Agreement;
(viii) securities issued in connection with license or sponsored research arrangements with strategic technology alliances approved by the Board of Directors, including the directors elected by the Series D-2 Holders; or (ix) any
securities deemed not to be New Securities by the holders of at least 70% of the Registrable Securities. 
 (b) If the Company
proposes to undertake an issuance of New Securities, it shall give the Rightholders written notice of its intention, describing the type of New Securities, the price and the general terms upon which the Company proposes to issue the same. The
Rightholders shall have twenty (20) days from the date of mailing of any such notice to agree to purchase their respective pro rata share of such New Securities for the price, and upon the general terms specified in the notice, by giving
written notice to the Company and stating therein the quantity of New Securities to be purchased. The Rightholders accepting such offer (the “Participating Rightholders”) may condition their acceptance on completion of the entire
transaction within a specified period of time at such price and on such other terms, participation of other Rightholders, or other reasonable criteria. 
 (c) If not all of the Rightholders elect to purchase their pro rata share of the New Securities, then the Company shall promptly notify in writing New Leaf Ventures II, L.P. (“New Leaf”) and
shall offer New Leaf the right to acquire such unsubscribed New Securities up to an amount so that the total amount of securities of the Company owned by new Leaf upon exercise of this right, taken together with all securities of the Company
previously acquired by New Leaf, shall not exceed 15% of the outstanding shares of Preferred Stock of the Company, taking into account the issuance of the New Securities (the “New Leaf Participation Right”), provided that New Leaf
(together with its affiliates) shall not at any time hold more than 15% of the Company’s outstanding Preferred Stock as a result of this New Leaf Participation right. New Leaf shall have ten (10) days after receipt of any such notice to
notify the Company of its election to purchase all or a portion thereof of the unsubscribed New Securities. Upon the earlier of New Leaf (i) holding 15% of the outstanding Preferred Stock or (ii) electing not to exercise its New Leaf
Participation Right in relation to an issuance of New Securities, the Company will have no further obligation to offer the New Leaf Participation Right to New Leaf. If New Leaf fails to exercise in full such New Leaf Participation Right or increases
its ownership to 15% of the Company’s Preferred Stock or if there are otherwise unsubscribed New Securities, the Company shall promptly notify in writing the Participating Rightholders who do so elect to purchase at least their pro rata share
of the New Securities (including New Leaf, if applicable) and shall offer such Participating Rightholders the right to acquire such unsubscribed shares in a 

  
 -12-









 
pro rata fashion. For avoidance of doubt, except pursuant to the New Leaf Participation Right as set forth in this Section 4.2(c), New Leaf may acquire or otherwise hold more than 15% of the
outstanding Preferred Stock of the Company. The Participating Rightholders shall have five (5) days after receipt of such notice to notify the Company of its election to purchase all or a portion thereof of the unsubscribed shares. If the
Participating Rightholders fail to exercise in full the rights of first refusal, the Company shall have ninety (90) days thereafter to sell the New Securities in respect of which the Rightholders’ rights were not exercised, at a price and
upon general terms and conditions not materially more favorable to the purchasers thereof than specified in the Company’s notice to the Rightholders pursuant to Section 4.2(b) hereof. If the Company has not sold such New Securities within
ninety (90) days of the notice provided pursuant to Section 4.2(b), the Company shall not thereafter issue or sell any New Securities, without first offering such securities to the Rightholders in the manner provided above. 

5. Termination of Covenants. 
 The covenants of the Company set forth in Section 2 and the right of first refusal set forth in Section 4 shall be terminated and be of no further force or effect upon the earliest of
(a) the consummation of a Qualified IPO, (b) a merger or consolidation in which the surviving corporation is a reporting company under the Exchange Act, (c) the date the Company registers any securities under the Exchange Act, and
(d) with respect to a particular Holder or Investor, at such times and for so long as the Holder or Investor no longer holds any shares of capital stock of the Company. 
 6. Demand Registration. 
 6.1 Request for Registration on Form
Other Than Form S-3. 
 (a) Subject to the terms of this Agreement, if the Company shall receive from the Initiating Holders
at any time after the earlier of December 31, 2011 and the Company’s initial public offering of shares of Common Stock under a Registration Statement, a written request that the Company effect any Registration with respect to at least 20%
of the Registrable Securities then held by all Holders of Registrable Securities, or a lesser number of Registrable Securities sufficient to comprise a reasonably anticipated aggregate offering price to the public not less than $7,000,000, the
Company shall at its expense (i) promptly give written notice of the proposed Registration to all other Holders and shall (ii) use its best efforts to effect Registration of the Registrable Securities specified in such request, together
with any Registrable Securities of any Holder joining in such request as are specified in a written request given within twenty (20) days after such Holder’s receipt of written notice of the Proposed Registration from the Company.

 (b) If, at any time at which the Company is eligible to file a registration statement on a Short-Form Registration Statement,
Holders propose to sell Registrable Securities with a reasonably anticipated aggregate offering price of at least $750,000 pursuant to a Short-Form Registration Statement, and if such Holders give the Company a written request that the Company
effect such Registration, the Company shall at its expense (i) promptly give written notice of the proposed Registration to all other Holders and shall (ii) use its best efforts to effect Registration of the Registrable Securities
specified in such request, together with any Registrable 

  
 -13-









 
Securities of any Holder joining in such request as are specified in a written request given within twenty (20) days after such Holder’s receipt of written notice of the proposed
Registration from the Company. The Company shall not be obligated to effect an initial public offering under this Section 6.1 unless such offering is a Qualified IPO (as appropriately adjusted for stock splits, dividends, reclassifications,
etc.). 
 6.2 Right of Deferral of Registration. 

The Company shall not be obligated to file a registration statement pursuant to this Section 6: 

(a) in any particular jurisdiction in which the Company would be required to execute a general consent to service of process in effecting
such registration, qualification, or compliance unless the Company is already subject to service in such jurisdiction and except as may be required by the Securities Act; 
 (b) If the Company, within ten (10) days of the receipt of the request of the Initiating Holders, gives notice of its bona fide intention to effect the filing of a registration statement with the
Commission within sixty (60) days of receipt of such request (other than with respect to a registration statement relating to a Rule 145 transaction or an offering solely to employees), provided that the Company is actively employing in good
faith all reasonable efforts to cause such registration statement to become effective; 
 (c) Within the one hundred eighty
(180) day period immediately following the effective date of the registration statement pertaining to the initial public offering of securities of the Company; or 
 (d) if the Company shall furnish to such Holders a certificate signed by the President of the Company stating that in the good faith judgment of the Board of Directors it would be seriously detrimental to
the Company or its shareholders for a registration statement to be filed in the near future, then the Company’s obligation to use its best efforts to file a registration statement shall be deferred for a period not to exceed one hundred twenty
(120) days from the receipt of the request to file such registration by such Holder provided that the Company shall not exercise the right contained in this paragraph (iv) more than once in any twelve (12) month period. 

6.3 Limitations on Required Registration. 
 The Company shall not be required to prepare and file (i) more than two (2) Long-Form Registration Statements, which actually become or are declared effective at the request of the Initiating
Holders pursuant to Section 6.1(a) hereof, or (ii) more than two (2) Short-Form Registration Statements in any 12 month period which actually become and are declared effective at the request of the Initiating Holders pursuant to
Section 6.1(b) hereof If pursuant to Section 6.5.4 the number of Registrable Securities to be included in a Registration is reduced by more than 50%, then such Registration shall not be counted toward the foregoing limitation on the number
of demand Registrations. 

  
 -14-









 6.4 Registration of Other Securities in Demand Registration. 

Any Registration Statement filed pursuant to the request of the Initiating Holders under this Section 6 may, subject to the
provisions of Section 6.5, include securities of the Company other than Registrable Securities. 
 6.5 Underwriting in
Demand Registration. 
 6.5.1 Notice of Underwriting. 

If the Initiating Holders intend to distribute the Registrable Securities covered by their request by means of an underwriting, they
shall so advise the Company as a part of their request made pursuant to this Section 6, and the Company shall include such information in the written notice referred to in Section 6.1. The right of any Holder to Registration pursuant to
Section 6 shall be conditioned upon such Holder’s agreement to participate in such underwriting and the inclusion of such Holder’s Registrable Securities in the underwriting. 

6.5.2 Inclusion of Other Holders in Demand Registration. 

If the Company, officers or directors of the Company or any other holders of Common Stock or other securities other than Registrable
Securities (collectively, “Other Stockholders”), request inclusion in such Registration, the Company may, upon obtaining the prior written consent of Holders of at least 70% of the Registrable Securities proposed to be included in
such Registration, offer to any of such Other Stockholders (including for its own account) the right to include securities held by such Other Stockholders in the underwriting and may condition such offer on the acceptance by such persons of the
terms of this Section 6. 
 6.5.3 Selection of Underwriter in Demand Registration. 

In connection with a Registration effected pursuant to Section 6.1, the Company shall (together with all Holders proposing to
distribute their securities through such underwriting) enter into an underwriting agreement with the representative (“Underwriter’s Representative”) of the underwriter or underwriters selected for such underwriting by the Holders of a
majority of the Registrable Securities being registered by the Initiating Holders, provided the same is reasonably acceptable to the Company. 
 6.5.4 Marketing Limitation in Demand Registration. 
 In the event the
Underwriter’s Representative advises the Initiating Holders in writing that market factors (including, without limitation, the aggregate number of shares of Common Stock requested to be Registered, the general condition of the market, and the
status of the persons proposing to sell securities pursuant to the Registration) require a limitation of the number of shares to be underwritten in the Registration initiated under this Section 6, then (i) first the Common Stock (other
than Registrable Securities) held by officers or directors of the Company shall be excluded from such Registration, (ii) next the securities other than Registrable Securities shall be excluded, (iii) next the securities requested to be
registered by the Company shall be excluded from such Registration, and (iv) finally, to the extent required by such limitation, the number of shares of Registrable Securities that may be included in the Registration and underwriting shall be
allocated among all Holders in proportion, as nearly as practicable, to the respective amounts of Registrable Securities entitled to inclusion in such 

  
 -15-









 
Registration held by such Holders at the time of filing the Registration Statement. No Registrable Securities or other securities excluded from the underwriting by reason of this
Section 6.5.4 shall be included in such Registration Statement. 
 6.5.5 Right of Withdrawal in Demand
Registration. 
 If any Holder of Registrable Securities, or a holder of other securities entitled (upon request) to be
included in such Registration, disapproves of the terms of the underwriting, such person may elect to withdraw therefrom by written notice to the Company, the underwriter and the Initiating Holders delivered at least seven days prior to the
effective date of the Registration Statement. The securities so withdrawn shall also be withdrawn from the Registration Statement. 
 6.6 Blue Sky in Demand Registration. 
 In the event of any Registration
pursuant to Section 6, the Company will exercise its reasonable best efforts to Register and qualify the securities covered by the Registration Statement under such other securities or Blue Sky laws of such jurisdictions as shall be reasonably
appropriate for the distribution of such securities. Notwithstanding anything in this Agreement to the contrary, in the event any jurisdiction in which the securities shall be qualified imposes a non-waivable requirement that expenses incurred in
connection with the qualification of the securities be borne by selling shareholders, such expenses shall be payable pro rata by selling shareholders. 
 7. Piggyback Registration. 
 7.1 Notice of Piggyback Registration
and Inclusion of Registrable Securities. 
 Subject to the terms of this Agreement, if the Company decides to Register any of its Common
Stock (either for its own account or the account of other security holders (other than a Registration under Section 6)) the Company will at its expense: (i) promptly give each Holder written notice thereof (which shall include a list of
the jurisdictions in which the Company intends to attempt to qualify such securities under the applicable Blue Sky or other state securities laws) at least thirty (30) days prior to the effective date of the applicable Registration Statement
and (ii) include in such Registration (and any related qualification under Blue Sky laws or other compliance), and in any underwriting involved therein, all the Registrable Securities specified in a written request delivered to the Company by
any Holder within twenty (20) days after such Holder’s receipt of such written notice of the proposed Registration from the Company; provided, however, that no Holder shall have rights pursuant to this Section 7 two
(2) years after the Company’s first public offering under the Securities Act if such Holder can sell all of such Holder’s Registrable Securities pursuant to Securities Act Rule 144 within a three (3) month period. 

7.2 Underwriting in Piggyback Registration. 
 7.2.1 Notice of Underwriting in Piggyback Registration. 
 If the
Registration of which the Company gives notice is for a Registered public offering involving an underwriting, the Company shall so advise the Holders as a part of the written 

  
 -16-









 
notice given pursuant to Section 7.1. In such event, the right of any Holder to Registration shall be conditioned upon such underwriting and the inclusion of such Holder’s Registrable
Securities in such underwriting to the extent provided in this Section 7. All Holders proposing to distribute their securities through such underwriting shall (together with the Company and the other holders distributing their securities
through such underwriting) enter into an underwriting agreement with the Underwriter’s Representative for such offering. The Holders shall have no right to participate in the selection of the underwriters for an offering pursuant to this
Section 7. 
 7.2.2 Marketing Limitation in Piggyback Registration. 

If the Underwriter’s Representative advises the Holders seeking registration of Registrable Securities pursuant to Section 7 in
writing that market factors (including, without limitation, the aggregate number of shares of Common Stock requested to be Registered, the general condition of the market, and the status of the persons proposing to sell securities pursuant to the
Registration) require a limitation of the number of shares to be underwritten, the Underwriter’s Representative (subject to the allocation priority set forth in Section 7.2.3) may: 

(a) in the case of the Company’s initial Registered public offering, exclude some or all Registrable Securities from such
registration and underwriting; and 
 (b) in the case of any Registered public offering subsequent to the initial public
offering, limit the number of shares of Registrable Securities to be included in such Registration and underwriting to not less than 25% of the securities included in such Registration (based on aggregate market values). 

7.2.3 Allocation of Shares in Piggyback Registration. 
 If the Underwriter’s Representative limits the number of shares to be included in a Registration pursuant to Section 7.2.2, the number of shares to be included in such Registration shall be
allocated (subject to Section 7.2.2) in the following manner: the shares (other than Registrable Securities) held by officers or directors of the Company shall be excluded from such registration and underwriting to the extent required by such
limitation. If a limitation of the number of shares is still required after such exclusion, the securities requested by the Company or any holders of securities other than the Holders of Registrable Securities shall be excluded, provided that if the
Registration originated for the purpose of permitting the Company to sell its securities pursuant to a firm commitment public offering, no more than 20% of the securities proposed to be sold by the Company shall be excluded. If a limitation of the
number of shares is still required after such exclusion, the number of shares that may be included in the Registration and underwriting by selling shareholders shall be allocated among all Holders of Registrable Securities entitled to inclusion in
such Registration, in proportion, as nearly as practicable, to the respective amounts of Registrable Securities which such Holders would otherwise be entitled to include in such Registration. No Registrable Securities or other securities excluded
from the underwriting by reason of this Section 7.2.3 shall be included in the Registration Statement. 
 7.2.4
Withdrawal in Piggyback Registration. 
 If any Holder disapproves of the terms of any such underwriting, such person may
elect to withdraw therefrom by written notice to the Company and the underwriter delivered at least 

  
 -17-









 
seven days prior to the effective date of the Registration Statement. Any Registrable Securities or other securities excluded or withdrawn from such underwriting shall be withdrawn from such
Registration. 
 7.3 Blue Sky in Piggyback Registration. 

In the event of any Registration of Registrable Securities pursuant to this Section 7, the Company will exercise its reasonable best
efforts to Register and qualify the securities covered by the Registration Statement under such other securities or Blue Sky laws of such jurisdictions (not exceeding twenty (20) unless otherwise agreed to by the Company) as shall be reasonably
appropriate for the distribution of such securities. Notwithstanding anything in this Agreement to the contrary, in the event any jurisdiction in which the securities shall be qualified imposes a non-waivable requirement that expenses incurred in
connection with the qualification of the securities be borne by selling shareholders, such expenses shall be payable pro rata by selling shareholders. 
 8. Expenses of Registration. 
 All Registration Expenses incurred in
connection with two Long-Form Registrations, four Short-Form Registrations and unlimited Registrations pursuant to Section 7 and fees and disbursements of one counsel for the Holders selected by the Holders and reasonably acceptable to the
Company not to exceed $50,000 for any single Registration shall be borne by the Company. All Registration Expenses incurred in connection with any other registration, qualification, or compliance, shall be apportioned among the Holders and other
holders of the securities so registered on the basis of the number of shares so registered. Notwithstanding the above, the Company shall not be required to pay for any expenses of any Registration proceeding begun pursuant to Section 6 if the
Registration request is subsequently withdrawn at the request of the Holders of a majority of the Registrable Securities to be registered, unless the Holders of a majority of the Registrable Securities agree to forfeit their right to one demand
registration pursuant to Section 6; provided further, however, that if at the time of such withdrawal, the Holders have learned of a Material Adverse Event with respect to the Company not known to the Holders at the time of their request, then
the Holders shall not be required to pay any of such expenses and shall retain their rights pursuant to Section 6. All Selling Expenses shall be borne by the holders of the securities Registered pro rata on the basis of the number of shares
Registered. 
 9. Reports Under Exchange Act. 

With a view to making available to the Holders the benefits of Securities Act Rule 144 promulgated under the Securities Act and any other
rule or regulation of the Commission that may at any time permit a Holder to sell securities of the Company to the public without registration or pursuant to a Registration, the Company agrees to: 

(a) use its reasonable best efforts to make and keep public information available, as those terms are understood and defined in
Securities Act Rule 144, at all times after ninety (90) days after the effective date of the first registration statement under the Act filed by the Company for the offering of its securities to the general public; 

  
 -18-









 (b) take such action, including the voluntary registration of its Common Stock under
Section 12 of the Exchange Act as is necessary to enable the Holders to utilize Short-Form Registration Statement for the sale of their Registrable Securities, such action to be taken as soon as practicable after the end of the fiscal year in
which the first registration statement filed by the Company for the offering of its securities to the general public is declared effective; 
 (c) use its reasonable best efforts to file with the Commission in a timely manner all reports and other documents required of the Company under the Securities Act and the Exchange Act; and 

(d) furnish to any Holder, so long as the Holder owns any Registrable Securities, forthwith upon request (i) a written statement by
the Company that it has complied with the reporting requirements of Securities Act Rule 144 (at any time after ninety (90) days after the effective date of the first registration statement filed by the Company for an offering of its securities
to the general public), the Securities Act and the Exchange Act (at any time after it has become subject to such reporting requirements), or that it qualifies as a registrant whose securities may be resold pursuant to Short-Form Registration
Statement (at any time after it so qualifies), (ii) a copy of the most recent annual or quarterly report of the Company and such other reports and documents so filed by the Company, and (iii) such other information as may be reasonably
requested by a Holder in availing itself of any rule or regulation of the Commission which permits a Holder to sell any such securities without registration or pursuant to such form. 

10. Termination of Registration Rights. 
 The rights to receive notice pursuant to Section 7 and to cause the Company to register securities granted under Sections 6 and 7 of this Agreement shall terminate, with respect to each Holder, on
the date five years after the closing date of the Company’s Qualified IPO. 
 11. Registration Procedures and
Obligations. 
 Whenever required under this Agreement to effect the registration of any Registrable Securities, the
Company shall, as expeditiously as reasonably possible: 
 (a) Prepare and file with the Commission a Registration Statement
with respect to such Registrable Securities and use its reasonable best efforts to cause such Registration Statement to become effective, and, upon the request of the Holders of a majority of the Registrable Securities registered thereunder, keep
such Registration Statement effective for up to one hundred twenty (120) days. 
 (b) Prepare and file with the Commission
such amendments and supplements to such Registration Statement and the prospectuses used in connection with such registration statement as may be necessary to keep such registration statement effective and current and comply with the provisions of
the Securities Act with respect to the disposition of all securities covered by such Registration Statement. 
 (c) Furnish to
the Holders such numbers of copies of a prospectus, including preliminary prospectuses, in conformity with the requirements of the Securities Act, and such other documents as they may reasonably request in order to facilitate the disposition of
Registrable Securities owned by them. 

  
 -19-









 (d) Use its reasonable best efforts to register and qualify the securities covered by such
registration statement under such other securities or Blue Sky laws of such jurisdictions as shall be reasonably requested by the Holders, provided that the Company shall not be required in connection therewith or as a condition thereto to qualify
to do business or to file a general consent to service of process in any such states or jurisdictions. 
 (e) In the event of
any underwritten public offering, enter into and perform its obligations under an underwriting agreement, in usual and customary form, with the managing underwriter of such offering and take such other usual and customary action as the Holders of a
majority of the Registrable Securities to be included in such Registration may request in order to facilitate the disposition of such Registrable Securities. 
 (f) Notify each Holder of Registrable Securities covered by such Registration Statement at any time when a prospectus relating thereto is required to be delivered under the Securities Act of the happening
of any event as a result of which the prospectus included in such Registration Statement, as then in effect, includes an untrue statement of a material fact or omits to state a material fact required to be stated therein or necessary to make the
statements therein not misleading in the light of the circumstances then existing. The Company will use all reasonable efforts to amend or supplement such prospectus in order to cause such prospectus not to include any untrue statement of a material
fact or omit to state a material fact required to be stated therein or necessary to make the statements therein not misleading in the light of the circumstances then existing. 
 (g) Provide a transfer agent and registrar for all Registrable Securities registered pursuant to such Registration Statement and a CUSIP number for all such Registrable Securities, in each case not later
than the effective date of such registration. 
 (h) Furnish, at the request of any Holder whose Registrable Securities are
included in any Registration pursuant to this Agreement, on the date that such Registrable Securities are delivered to the underwriters for sale in connection with a registration pursuant to this Agreement, (i) an opinion, dated such date, of
the counsel representing the Company for the purposes of such registration, in form and substance as is customarily given to underwriters in an underwritten public offering, addressed to the underwriters, if any, and to the Holders, and (ii) a
letter dated such date, from the independent certified public accountants of the Company, in form and substance as is customarily given by independent certified public accountants to underwriters in an underwritten public offering, addressed to the
underwriters. 
 (i) Cause all such Registrable Securities to be included in a Registration pursuant to this Agreement to be
listed on each securities exchange or other securities trading markets or which similar securities issued by the Company are then listed. 

  
 -20-









 12. Information Furnished by Holder. 

Each Holder of Registrable Securities included in any Registration shall furnish to the Company such information regarding such Holder
and the distribution proposed by such Holder or Holders as the Company may reasonably request. 
 13. Indemnification.

 13.1 Company’s Indemnification of Holders. 

To the extent permitted by law, the Company will indemnify each Holder, each of its officers, directors, and constituent partners, legal
counsel for each Holder, and each person controlling such Holder, with respect to which Registration, related qualification, or related compliance of Registrable Securities has been effected pursuant to this Agreement, and each underwriter, if any,
and each person who controls any underwriter within the meaning of the Securities Act against all claims, losses, damages, or liabilities (or actions in respect thereof) to the extent such claims, losses, damages, or liabilities arise out of or are
based upon (i) any untrue statement (or alleged untrue statement) of a material fact contained in any prospectus or other document (including any related Registration Statement) incident to any such Registration, qualification, or compliance,
or (ii) any omission (or alleged omission) to state therein a material fact required to be stated therein or necessary to make the statements therein not misleading, or (iii) any violation or alleged violation by the Company of the
Securities Act, the Exchange Act, any state securities law, or any rule or regulation promulgated under the Securities Act, the Exchange Act or any state securities law applicable to the Company and relating to action or inaction required of the
Company in connection with any such Registration, qualification, or compliance; and the Company will pay as incurred to each such Holder, each such underwriter, and each person who controls any such Holder or underwriter, any legal and any other
expenses reasonably incurred in connection with investigating or defending any such claim, loss, damage, liability, or action; provided, however, that the indemnity contained in this Section 13.1 shall not apply to amounts paid in
settlement of any such claim, loss, damage, liability, or action if settlement is effected without the consent of the Company (which consent shall not unreasonably be withheld); and provided, further, that the Company will not be liable in any such
case to the extent that any such claim, loss, damage, liability, or expense arises out of or is based upon any untrue statement or omission contained in such prospectus or other document based upon written information furnished to the Company by
such Holder, underwriter, or controlling person and stated to be for use therein. 
 13.2 Holder’s Indemnification of
Company. 
 To the extent permitted by law, each Holder (severally and not jointly) will, if Registrable Securities held by
such Holder are included for sale in the Registration and related qualification and compliance effected pursuant to this Agreement, indemnify the Company, each of its directors, each officer of the Company who signs the applicable Registration
Statement, each legal counsel and each underwriter of the Company’s securities covered by such a Registration Statement, each person who controls the Company or such underwriter within the meaning of the Securities Act against all claims,
losses, damages, and liabilities (or actions in respect thereof) arising out of or based upon (i) any untrue statement (or alleged untrue statement) of a material fact contained in any such Registration Statement, or related document, or
(ii) any omission (or alleged omission) to state therein a material fact required to be stated therein or necessary to 

  
 -21-









 
make the statements therein not misleading, or (iii) any violation or alleged violation by such Holder of the Securities Act, the Exchange Act, any state securities law, or any rule or
regulation promulgated under the Securities Act, the Exchange Act or any state securities law applicable to such Holder and relating to action or inaction required of such Holder in connection with any such Registration and related qualification and
compliance, and will pay as incurred to such persons, any legal and any other expenses reasonably incurred in connection with investigating or defending any such claim, loss, damage, liability, or action, in each case only to the extent that such
untrue statement (or alleged untrue statement) or omission (or alleged omission) is made in (and such violation pertains to) such Registration Statement or related document in reliance upon and in conformity with written information furnished to the
Company by such Holder and stated to be specifically for use therein; provided, however, that the indemnity contained in this Section 13.2 shall not apply to amounts paid in settlement of any such claim, loss, damage, liability, or action if
settlement is effected without the consent of such Holder (which consent shall not unreasonably be withheld); provided, further, that such Holder’s liability under this Section 13.2 (when combined with any amounts Holder is liable for
under Section 13.4) shall not exceed such Holder’s net proceeds from the offering of securities made in connection with such Registration. 
 13.3 Indemnification Procedure. 
 Promptly after receipt by an indemnified
party under this Section 13 of notice of the commencement of any action, such indemnified party will, if a claim in respect thereof is to be made against an indemnifying party under this Section 13, notify the indemnifying party in writing
of the commencement thereof and generally summarize such action. The indemnifying party shall have the right to participate in and to assume the defense of such claim; provided, however, that the indemnifying party shall be entitled to
select counsel for the defense of such claim with the approval of any parties entitled to indemnification, which approval shall not be unreasonably withheld; provided further, however, that if either party reasonably determines that there may be a
conflict between the position of the Company and the Holders in conducting the defense of such action, suit, or proceeding by reason of recognized claims for indemnity under this Section 13, then counsel for such party shall be entitled to
conduct the defense to the extent reasonably determined by such counsel to be necessary to protect the interest of such party. The failure to notify an indemnifying party promptly of the commencement of any such action, if prejudicial to the ability
of the indemnifying party to defend such action, shall relieve such indemnifying party, to the extent so prejudiced, of any liability to the indemnified party under this Section 13, but the omission so to notify the indemnifying party will not
relieve such party of any liability that such party may have to any indemnified party otherwise than under this Section 13. 
 13.4 Contribution. 
 If the indemnification provided for in this
Section 13 is held by a court of competent jurisdiction to be unavailable to an indemnified party with respect to any loss, liability, claim, damage, or expense referred to therein, then the indemnifying party, in lieu of indemnifying such
indemnified party hereunder, shall contribute to the amount paid or payable by such indemnified party as a result of such loss, liability, claim, damage, or expense in such proportion as is appropriate to reflect the relative fault of the
indemnifying party on the one hand and of the indemnified party on the other in connection with the statements or omissions that resulted in 

  
 -22-









 
such loss, liability, claim, damage, or expense as well as any other relevant equitable considerations. The relative fault of the indemnifying party and of the indemnified party shall be
determined by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the omission to state a material fact relates to information supplied by the indemnifying party or by the indemnified party and the
parties’ relative intent, knowledge, access to information, and opportunity to correct or prevent such statement or omission. In no event, however, shall (a) any amount due for contribution hereunder be in excess of the amount that would
otherwise be due under Section 13.1 or 13.2, as applicable, based on the limitations of such provisions and (b) a person guilty of fraudulent misrepresentation (within the meaning of the Securities Act) be entitled to contribution from a
person who was not guilty of such fraudulent misrepresentation. 
 13.5 Conflicts. 

Notwithstanding the foregoing, to the extent that the provisions on indemnification and contribution contained in the underwriting
agreement entered into in connection with an underwritten public offering are in conflict with the foregoing provisions, the provisions in the underwriting agreement shall control; provided, however, that the failure of the
underwriting agreement to provide for or address a matter provided for or addressed by the foregoing provisions shall not be a conflict between the underwriting agreement and the foregoing provisions. 

13.6 Survival. 
 The obligations of the Company and Holders under this Section 13 shall survive the completion of any offering of Registrable Securities in a registration statement under this Agreement or otherwise.

 14. Limitations on Registration Rights Granted to Other Securities. 

From and after the date of this Agreement, the Company shall not enter into any agreement with any holder or prospective holder of any
securities of the Company providing for the granting to such holder of any information or Registration rights, except that, with the consent of the Holders of 75% percent of the aggregate of the Registrable Securities then outstanding, additional
holders may be added as parties to this Agreement with regard to any or all securities of the Company held by them. Any such additional parties shall execute a counterpart of this Agreement, and upon execution by such additional parties and by the
Company, shall be considered an Investor for all purposes of this Agreement. The additional parties and the additional Registrable Securities shall be identified in an amendment to Schedule 1.1 hereto. Notwithstanding the foregoing, additional
persons purchasing shares of Series D-2 Preferred Stock pursuant to the Series D-2 Purchase Agreement may be added as parties hereto upon execution of a signature page to this Agreement and by the inclusion of such person’s name on Schedule 1.1
hereto. 
 15. Transfer of Rights. 
 The rights granted by the Company to the Investors under this Agreement may be assigned by any Investor (along with any obligations of such Investor) from time to time in


  
 -23-









 
whole or in part to a transferee or assignee of any Convertible Securities or Registrable Securities acquiring at least 10,000 shares of such Holder’s Registrable Securities (equitably
adjusted for any stock splits, subdivisions, stock dividends, changes, combinations or the like) (a “Permitted Transferee”); provided, however, that (i) the Company must receive written notice of said transfer no
later than fifteen (15) days prior to the transfer, and (ii) the transferee or assignee of such rights must not be a person deemed by the Board of Directors of the Company, in its best judgment, within ten (10) days after the Company
receives notice of such transfer, to be a competitor of the Company. Notwithstanding the limitations set forth in the foregoing sentence, no restrictions shall apply to a transfer by: (i) an Investor which is a limited or general partnership or
limited liability company to its constituent general or limited partners or members or a retired partner or member of such partnership or limited liability company who retires after the date hereof, or to the estate of any such partner or member or
retired partner or member or transfer by gift, will or intestate succession to any such partner’s or member’s spouse or lineal descendants or ancestors, or up to three dispositions per calendar year by any such partner or member to any
other trust established by such member or partner, or to any affiliated limited or general partnership or limited liability company or other investment fund under common control or investment management, (ii) an Investor to any spouse or to the
siblings, lineal descendants or ancestors of such Investor or his or her spouse or a trust for the benefit of any such persons, or (iii) an Investor to any affiliated venture capital fund of any investor; if in each such case the transferee
agrees in writing to be subject to the terms of this Agreement to the same extent if such transferee were an Investor; provided, however, that each Investor hereby covenants not to effect such transfer if such transfer either would
invalidate the securities laws exemptions pursuant to which the Registrable Securities were originally offered and sold or would itself require registration under the Securities Act or applicable state securities laws. 

16. Market Stand-off. 
 Each Holder hereby agrees that, if so requested by the Underwriter’s Representative (if any) in connection with the Company’s initial public offering, such Holder shall not sell, make any short
sale of, loan, grant any option for the purchase of, or otherwise transfer or dispose of any Registrable Securities or other securities of the Company without the prior written consent of the Company and the Underwriter’s Representative for
such period of time (not to exceed 180 days but subject to such extensions as may be required by the underwriters in order to publish research reports while complying with NASD Rule 2711 of the Financial Industry Regulatory Authority) following the
effective date of a Registration Statement of the Company filed under the Securities Act as may be requested by the Underwriter’s Representative. Each Holder also agrees that in connection with the Company’s initial public offering the
Holder will enter into a lock-up agreement in the form presented by the Underwriter’s Representative consistent with this Section 16. The obligations of Holders under this Section 16 shall be conditioned upon (a) all officers and
directors of the Company being bound by and entering into similar agreements and (b) the Company using all reasonable efforts to obtain similar agreements from all other holders of at least 1% of the Company’s outstanding shares. If any
officer, director or other stockholder of the Company is granted an early release with respect to all or a portion of the securities held by such holder from such holder’s lock-up agreement, then each Holder shall also be granted an early
release from its obligations hereunder on a pro-rata basis based on the aggregate percentage of shares held by the officers, directors or stockholders being released from such holder’s lock-up agreements. 

  
 -24-









 17. No-Action Letter or Opinion of Counsel in Lieu of Registration.

 Notwithstanding anything else in this Agreement, if a proposed disposition by Holders is of Registrable Securities having
aggregate proceeds of $750,000 or less and the Company shall have obtained from the Commission a “no-action” letter in which the Commission has indicated that it will take no action if, without Registration under the Securities Act, any
Holder disposes of Registrable Securities covered by any request for Registration made under this Section in the specific manner in which such Holder proposes to dispose of the Registrable Securities included in such request (such as including,
without limitation, inclusion of such Registrable Securities in an underwriting initiated by either the Company or the Holders), or if in the opinion of counsel for the Company concurred in by counsel for such Holder no Registration under the
Securities Act is required in connection with disposition and provided that such disposition is otherwise permitted by this Agreement, the Registrable Securities shall not be eligible for Registration under this Agreement and the Company will not be
required to send notice to the Holder pursuant to Section 7. The Registration Rights of the Holders of the Registrable Securities set forth in this Agreement are conditioned upon the conversion of the Convertible Securities with respect to
which Registration is sought into Common Stock prior to the effective date of the Registration Statement. 
 18.
Miscellaneous. 
 18.1 Governing Law. 

This Agreement shall be governed by, and construed in accordance with, the laws of the State of California excluding those laws that
direct the application of the laws of another jurisdiction. 
 18.2 Counterparts. 

This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall
constitute one and the same instrument. 
 18.3 Headings. 

The headings of the Sections of this Agreement are for convenience and shall not by themselves determine the interpretation of this
Agreement. 
 18.4 Notices. 
 Any notice required or permitted hereunder shall be given in writing and shall be conclusively deemed effectively given upon personal delivery, or five days after deposit in the United States mail, by
registered or certified mail, postage prepaid, addressed (i) if to the Company, as set forth below the Company’s name on the signature page of this Agreement, and (ii) if to an Investor, at such Investor’s address as set forth on
Schedule 1.1 or such Investor’s counterparty signature page hereto, or at such other address as the Company or such Investor may designate by 10 days advance written notice to the Investors or the Company, respectively. 

  
 -25-









 18.5 Amendment of Agreement. 

Any provision of this Agreement may be amended only by a written instrument signed by the Company and by persons holding at least 70% of
the Registrable Securities as defined in Section 1 of this Agreement. In addition to the foregoing, (a) any amendment or waiver that reduces the rights or increases the obligations of any Investor without reducing the rights or increasing
the obligations of other Investors in a manner that is similar or proportional shall require the written consent of such uniquely affected Investor, and (b) any amendment or waiver of any of the rights and obligations of any Investor which is
an SBIC Investor in such Investor’s capacity as an SBIC Investor under this Agreement shall require the prior written consent of such Investor. Adding (A) additional purchasers of Convertible Securities as Investors pursuant to
Section 14, and (B) Permitted Transferees acquiring shares in accordance with Section 15, shall not be deemed an amendment to this Agreement. 
 18.6 Severability. 
 In the event one or more of the provisions of this
Agreement should, for any reason, be held to be invalid, illegal or unenforceable in any respect, such invalidity, illegality, or unenforceability shall not affect any other provisions of this Agreement, and this Agreement shall be construed as if
such invalid, illegal or unenforceable provision had never been contained herein. 
 18.7 Delays or Omissions 

It is agreed that no delay or omission to exercise any right, power, or remedy accruing to any party, upon any breach, default or
noncompliance by another party under this Agreement shall impair any such right, power, or remedy, nor shall it be construed to be a waiver of any such breach, default or noncompliance, or any acquiescence therein, or of any similar breach, default
or noncompliance thereafter occurring. It is further agreed that any waiver, permit, consent, or approval of any kind or character on any party’s part of any breach, default or noncompliance under the Agreement or any waiver on such
party’s part of any provisions or conditions of this Agreement must be in writing and shall be effective only to the extent specifically set forth in such writing. All remedies, either under this Agreement, by law, or otherwise afforded to any
party, shall be cumulative and not alternative. 
 18.8 Entire Agreement; Successors and Assigns. 

This Agreement constitutes the entire agreement between the Company and the Investors relative to the subject matter hereof Any previous
agreements between the Company and any Investor, including but not limited to the Prior Agreement, concerning the subject matter hereof are superseded by this Agreement. All rights granted under the Prior Agreement, including any rights to purchase
the Series D-2 Preferred Stock, have been satisfied, and to the extent not satisfied are hereby waived by this Agreement. Subject to the exceptions specifically set forth in this Agreement, the terms and conditions of this Agreement shall inure to
the benefit of and be binding upon the respective executors, administrators, heirs, successor, and assigns of the parties. 

18.9 Merger with Trimeris, Inc. Notwithstanding the foregoing, the provisions of this Agreement (other than those in Sections 2, 3
and 4) shall remain in effect with respect to any shares of Trimeris, Inc. received in exchange for Registrable Securities in connection with the 

  
 -26-









 
transactions contemplated by the Agreement and Plan of Merger and Reorganization, dated as of June 13, 2011, by and among, Trimeris, Inc., Tesla Merger Sub, Inc. and the Company, treating
for this purpose the consummation of such transactions as a Qualified IPO.” 
 * * * 

  
 -27-









 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the day and year
first above written. 
  

							
	COMPANY:	 	 	 	SYNAGEVA BIOPHARMA CORP.
				
		 		 	By:	 	 /s/ Sanj K. Patel

		 		 		 	Sanj K. Patel
		 		 		 	President and Chief Executive Officer

  

							
		 		 	Address:	 	60 Hickory Drive
		 		 		 	Waltham, MA 02451
				
	INVESTORS:	 		 		 	

 SIGNATURE PAGE TO AMENDED AND RESTATED 

REGISTRATION RIGHTS AGREEMENT 

  
 -28-









 
			
	BAKER BROS. INVESTMENTS, L.P.
	By:	 	Baker Bros. Capital, L.P.,
		 	its general partner
	By:	 	Baker Bros. Capital (GP), LLC,
		 	its general partner
		
	By:	 	 /s/ Felix Baker, Ph.D.

		 	Felix Baker, Ph.D.
		 	Managing Member
	
	BAKER BROS. INVESTMENTS II, L.P.
	By:	 	Baker Bros. Capital, L.P.,
		 	its general partner
	By:	 	Baker Bros. Capital (GP), LLC,
		 	its general partner
		
	By:	 	 /s/ Felix Baker, Ph.D.

		 	Felix Baker, Ph.D.
		 	Managing Member
	
	FBB ASSOCIATES
		
	By:	 	 /s/ Felix Baker, Ph.D.

		 	Felix Baker, Ph.D.
		 	General Partner


 SIGNATURE PAGE TO AMENDED AND RESTATED 

REGISTRATION RIGHTS AGREEMENT 

  
 -29-









 
			
	BAKER BROTHERS LIFE SCIENCES, L.P.
	By:	 	Baker Brothers Life Sciences Capital, L.P.,
		 	its general partner
	By:	 	Baker Brothers Life Sciences Capital (GP),
		 	LLC, its general partner
		
	By:	 	 /s/ Felix Baker, Ph.D.

		 	Felix Baker, Ph.D.
		 	Managing Member
	
	14159, L.P.
	By:	 	14159 Capital, L.P.,
		 	its general partner
	By:	 	14159 Capital (GP), LLC,
		 	LLC, its general partner
		
	By:	 	 /s/ Felix Baker, Ph.D.

		 	Felix Baker, Ph.D.
		 	Managing Member
	
	667, L.P.
	By:	 	Baker Biotech Capital, L.P.,
		 	its general partner
	By:	 	Baker Biotech Capital (GP), LLC,
		 	its general partner
		
	By:	 	 /s/ Felix Baker, Ph.D.

		 	Felix Baker, Ph.D.
		 	Managing Member
	
	BAKER TISCH INVESTMENTS, L.P.
	By:	 	Baker/Tisch Capital, L.P.,
		 	its general partner
	By:	 	Baker/Tisch Capital (GP), LLC,
		 	its general partner
		
	By:	 	 /s/ Felix Baker, Ph.D.

		 	Felix Baker, Ph.D.
		 	Managing Member


 SIGNATURE PAGE TO AMENDED AND RESTATED 

REGISTRATION RIGHTS AGREEMENT 

  
 -30-









 
			
	TD JAVELIN CAPITAL FUND II, LP.
		
	By:	 	TD II Regional Partners, Inc.,
		 	its general partner
		
	By:	 	 /s/ James L.L. Tullis

		 	James L.L. Tullis
		 	President and Chief Executive Officer


 
			
		
	Address:	 	One Stamford Plaza, 12th Floor
		 	263 Tressler Boulevard
		 	Stamford, CT 06901


 
			
	
	TD LIGHTHOUSE CAPITAL FUND II, LP.
		
	By:	 	TD II Regional Partners, Inc.,
		 	its general partner
		
	By:	 	 /s/ James L.L. Tullis

		 	James L.L. Tullis
		 	President and Chief Executive Officer


 
			
		
	Address:	 	One Stamford Plaza, 12th Floor
		 	263 Tressler Boulevard
		 	Stamford, CT 06901


 
			
	
	TULLIS-DICKERSON CAPITAL FOCUS II, LP.
		
	By:	 	Tullis-Dickerson Partners II, LLC,
		 	its general partner
		
	By:	 	 /s/ James L.L. Tullis

		 	James L.L. Tullis
		 	Manager


 
			
		
	Address:	 	One Stamford Plaza, 12th Floor
		 	263 Tressler Boulevard
		 	Stamford, CT 06901


 SIGNATURE PAGE TO AMENDED AND RESTATED 

REGISTRATION RIGHTS AGREEMENT 

  
 -31-









 
					
	FOUR PARTNERS
		
	By:	 	 /s/ Thomas J. Tisch

		 	Thomas J. Tisch,
		 	Manager



 

					
	Address:	 	655 Madison Avenue
		 	19th Floor
		 	New York, MY 10065-8068



 

					
	TEN PARTNERS
		
	By:	 	 /s/ Thomas J. Tisch

		 	Thomas J. Tisch,
		 	Manager



 

					
	Address:	 	655 Madison Avenue
		 	19th Floor
		 	New York, MY 10065-8068


 SIGNATURE PAGE TO AMENDED AND RESTATED 

REGISTRATION RIGHTS AGREEMENT 

  
 -32-









 
					
	NEW LEAF VENTURES II, L.P.
		
	By:	 	New Leaf Venture Associates U, L.P.
		 	Its: General Partner
		
	By:	 	New Leaf Venture Management II, L.L.C.
		 	Its: General Partner
		
	By:	 	 /s/ Srinivas Akkaraju

		 	Srinivas Akkaraju
		 	Managing Director
			
		 	Address:	 	2500 Sand Hill Road, Suite 203
		 		 	Menlo Park, CA 94025


 SIGNATURE PAGE TO AMENDED AND RESTATED 
 INFORMATION AND REGISTRATION RIGHTS AGREEMENT 

  
 -33-









 
					
	HUNT-BIOVENTURES, L.P.
		
	By:	 	 /s/ J. Fulton Murray, III

		 	J. Fulton Murray, III
		 	Managing Director



 

			
	Address:	 	1900 N. Akard Street
		 	Dallas, Texas 75201


 SIGNATURE PAGE TO AMENDED AND RESTATED 

INFORMATION AND REGISTRATION RIGHTS AGREEMENT 

  
 -34-









 
			
	MAUI INVESTMENT COMPANY LIMITED
		
	By:	 	Heng-Yek Kuo
		 	President
		
	By:	 	 /s/ Heng Yek Ko





			
		
	Address:	 	Tower 2 Centerstage
		 	Flat 15A
		 	108 Hollywood Road
		 	Central, Hong Kong
		 	Hong Kong


 SIGNATURE PAGE TO AMENDED AND RESTATED 

REGISTRATION RIGHTS AGREEMENT 

  
 -35-









 
			
	TARAVAL ASSOCIATES SEED CAPITAL FUND, L.P.
		
	By:	 	 /s/ G.F. Murphy, Jr.

		 	G.F. Murphy, Jr.
		 	General Partner


 
			
		
	Address:	 	845 Oak Grove Avenue, Suite 220
		 	Menlo Park, CA 94025
	
	TARAVAL ASSOCIATES ANNEX FUND, L.P.


 
			
		
	By:	 	 /s/ G.F. Murphy, Jr.

		 	G.F. Murphy, Jr.
		 	General Partner


 
			
		
	Address:	 	845 Oak Grove Avenue, Suite 220
		 	Menlo Park, CA 94025


 SIGNATURE PAGE TO AMENDED AND RESTATED 

REGISTRATION RIGHTS AGREEMENT 

  
 -36-









 
			
	 /s/ Kent D. Mitchell

	KENT D. MITCHELL
		
	Address:	 	5505 Mount Vernon Parkway, NW
		 	Atlanta, GA 30327-4738
	
	 /s/ K. Deane Reade, Jr.

	K. DEANE READE, JR.
		
	Address:	 	Banger Fawes Reade Davis & Thom
		 	399 E. 72nd Street
		 	New York, NY 10021


 SIGNATURE PAGE TO AMENDED AND RESTATED 

REGISTRATION RIGHTS AGREEMENT 

  
 -37-









 
			
	 /s/ Sanj K. Patel

	SANJ K. PATEL
		
	Address:	 	c/o Synageva BioPharma Corp.
		 	60 Hickory Dr.
		 	Waltham, MA 02451


 SIGNATURE PAGE TO AMENDED AND RESTATED 

INFORMATION AND REGISTRATION RIGHTS AGREEMENT 

  
 -38-