<PAGE>
                                 UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 10-Q

      (Mark One)

      [X]  QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
           EXCHANGE ACT OF 1934

      FOR QUARTERLY PERIOD ENDED JUNE 30, 2004

                                       OR

      [ ]  TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
           EXCHANGE ACT OF 1934

                         Commission File Number: 0-20117

                          ENCYSIVE PHARMACEUTICALS INC.
--------------------------------------------------------------------------------
             (Exact name of registrant as specified in its charter)

           Delaware                                     13-3532643
--------------------------------------------------------------------------------
(State or other jurisdiction of             (I.R.S. Employer Identification No.)
incorporation or organization)

           6700 West Loop South, 4th Floor, Bellaire, Texas        77401
--------------------------------------------------------------------------------
            (Address of principal executive office)              (Zip code)

                                 (713) 796-8822
--------------------------------------------------------------------------------
              (Registrant's telephone number, including area code)

                                 Not Applicable
--------------------------------------------------------------------------------
         (Former name, former address and former fiscal year, if changed
                               since last report)

Indicate by check mark whether the registrant: (1) has filed all reports
required to be filed by Section 13 or 15(d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the
registrant was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days.

Yes   X    No  ___
    -----

Indicate by check mark whether the registrant is an accelerated filer (as
defined in Rule 12b-2 of the Exchange Act).

Yes   X    No  ___
    -----

Indicate the number of shares outstanding of each of the issuer's classes of
Common Stock, exclusive of treasury shares, as of the latest practicable date.

<TABLE>
<CAPTION>
                Class                     Outstanding at July 20, 2004
                -----                     ----------------------------
<S>                                       <C>
   Common stock, $0.005 par value                  53,030,738
</TABLE>
<PAGE>
                          ENCYSIVE PHARMACEUTICALS INC.

                                TABLE OF CONTENTS

<TABLE>
<CAPTION>
                                                                                        PAGE NO.
                                                                                        --------
<S>                                                                                     <C>
Part I.    Financial Information

           Item 1:   Financial Statements (Unaudited)

           Consolidated Balance Sheets as of June 30, 2004 and December 31, 2003            1

           Consolidated Statements of Operations and Comprehensive Loss for the
           three and six months ended June 30, 2004 and 2003                                2

           Consolidated Statements of Cash Flows for the six months ended
           June 30, 2004 and 2003                                                           3

           Notes to Consolidated Financial Statements                                       4

           Item 2:   Management's Discussion And Analysis Of
                     Financial Condition And Results Of Operations                         10

           Item 3:   Quantitative And Qualitative Disclosures
                     About Market Risk                                                     20

           Item 4:   Controls And Procedures                                               20

Part II.   Other Information

           Item 1:   Legal Proceedings                                                     21

           Item 2:   Changes In Securities, Use Of Proceeds and
                     Issuer Purchases of Equity Securities                                 21

           Item 3:   Defaults Upon Senior Securities                                       21

           Item 4:   Submission Of Matters To A Vote Of Security Holders                   21

           Item 5:   Other Information                                                     21

           Item 6:   Exhibits And Reports On Form 8-K                                      22

SIGNATURES                                                                                 23
</TABLE>
<PAGE>
                 ENCYSIVE PHARMACEUTICALS INC. AND SUBSIDIARIES

                           CONSOLIDATED BALANCE SHEETS
                     ($ IN THOUSANDS, EXCEPT PER SHARE DATA)
                                   (UNAUDITED)

<TABLE>
<CAPTION>
                                                                                                 JUNE 30,       DECEMBER 31,
ASSETS                                                                                             2004             2003
------                                                                                             ----             ----
<S>                                                                                             <C>             <C>
Current assets:
          Cash and cash equivalents                                                             $  26,529       $  65,302
          Short-term investments                                                                   32,064          11,218
          Short-term investments pledged as collateral for letter of credit                            --           7,011
          Accounts receivable                                                                       2,059           1,834
          Other current receivables                                                                   291             712
          Prepaids                                                                                  1,051             727
                                                                                                ---------       ---------
                 Total current assets                                                              61,994          86,804

Long-term investments                                                                               2,006           1,957
Equipment and leasehold improvements, net                                                           4,897           4,980
Intangible and other assets, net of accumulated amortization of $421 and $368                         604             657
                                                                                                ---------       ---------
                 Total assets                                                                   $  69,501       $  94,398
                                                                                                =========       =========
LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities:
          Accounts payable                                                                      $   3,653       $   2,404
          Accrued expenses                                                                          5,693           5,904
          Deferred revenue                                                                            561             561
          Current maturity on long-term debt                                                           --           6,000
                                                                                                ---------       ---------
                 Total current liabilities                                                          9,907          14,869

Deferred revenue                                                                                    1,399           1,680
Long-term debt, less current maturity                                                               1,557           1,610
Minority interest in Revotar                                                                        1,085           1,383

Commitments and contingencies

Stockholders' equity:
          Preferred stock, par value $.005 per share.  5,000,000 shares
                 authorized, none issued or outstanding                                                --              --
          Common stock, par value $.005 per share.  At June 30, 2004
                 75,000,000 shares authorized; 53,234,825 shares issued, 53,021,825 shares
                 outstanding.  At December 31, 2003, 75,000,000 shares authorized;
                 52,457,167 shares issued, 52,244,167 shares outstanding                              266             262
          Additional paid-in capital                                                              263,677         259,761
          Deferred compensation expense                                                              (245)           (185)
          Treasury stock, 213,000 shares                                                           (1,602)         (1,602)
          Accumulated other comprehensive income                                                      342              78
          Accumulated deficit                                                                    (206,885)       (183,458)
                                                                                                ---------       ---------
                 Total stockholders' equity                                                        55,553          74,856
                                                                                                ---------       ---------
                 Total liabilities and stockholders' equity                                     $  69,501       $  94,398
                                                                                                =========       =========
</TABLE>

           See accompanying notes to consolidated financial statements

                                       1
<PAGE>
                 ENCYSIVE PHARMACEUTICALS INC. AND SUBSIDIARIES

                      CONSOLIDATED STATEMENTS OF OPERATIONS
                             AND COMPREHENSIVE LOSS
                     ($ in thousands, except per share data)
                                   (Unaudited)

<TABLE>
<CAPTION>
                                                              THREE MONTHS ENDED JUNE 30,          SIX MONTHS ENDED JUNE 30,
                                                              ---------------------------          -------------------------
                                                                  2004              2003             2004              2003
                                                                  ----              ----             ----              ----
<S>                                                          <C>               <C>               <C>               <C>
Revenues:
        Research agreements                                  $       761       $       742       $     1,522       $     1,484
        Collaborative research and development from
               Encysive, L.P.                                         --                --                --               664
        Royalty income, net                                        1,960             1,113             3,752             2,260
        License fees, milestones and grants                          669               373               951             1,036
                                                             -----------       -----------       -----------       -----------
               Total revenues                                      3,390             2,228             6,225             5,444
                                                             -----------       -----------       -----------       -----------
Expenses:
        Research and development                                  13,193             6,304            25,208            10,523
        Equity in loss of Encysive, L.P.                              --                --                --             2,386
        Purchase of in-process research and development               --             8,363                --             8,363
        General and administrative                                 2,742             2,258             5,227             4,412
                                                             -----------       -----------       -----------       -----------
               Total expenses                                     15,935            16,925            30,435            25,684
                                                             -----------       -----------       -----------       -----------
               Operating loss                                    (12,545)          (14,697)          (24,210)          (20,240)

Investment income, net                                               135               264               485               637
                                                             -----------       -----------       -----------       -----------
               Loss before minority interest                     (12,410)          (14,433)          (23,725)          (19,603)

Minority interest in loss of Revotar                                 104               313               298               503
                                                             -----------       -----------       -----------       -----------
        Net loss                                                 (12,306)          (14,120)          (23,427)          (19,100)

Other comprehensive income:
        Unrealized gain on foreign currency translation              185               106               264               167
                                                             -----------       -----------       -----------       -----------
               Comprehensive loss                            $   (12,121)      $   (14,014)      $   (23,163)      $   (18,933)
                                                             ===========       ===========       ===========       ===========
Net loss per common share-
        basic and diluted                                    $     (0.23)      $     (0.32)      $     (0.45)      $     (0.44)
                                                             ===========       ===========       ===========       ===========
Weighted average common shares used to
        compute basic and diluted net loss per share          52,549,921        43,763,903        52,364,026        43,744,573
                                                             ===========       ===========       ===========       ===========
</TABLE>

           See accompanying notes to consolidated financial statements

                                       2
<PAGE>
                 ENCYSIVE PHARMACEUTICALS INC. AND SUBSIDIARIES

                      CONSOLIDATED STATEMENTS OF CASH FLOWS

                                ($ IN THOUSANDS)
                                   (UNAUDITED)

<TABLE>
<CAPTION>
                                                                                    SIX MONTHS ENDED JUNE 30,
                                                                                    -------------------------
                                                                                       2004           2003
                                                                                       ----           ----
<S>                                                                                 <C>             <C>
CASH FLOWS FROM OPERATING ACTIVITIES:
    Net loss                                                                         $(23,427)      $(19,100)
    Adjustments to reconcile net loss to net cash
      used in operating activities:
           Depreciation and amortization                                                  548            522
           Equity in loss of Encysive, L.P.                                                --          2,386
           Purchase of in-process research and development                                 --          8,363
           Minority interest in loss of Revotar                                          (298)          (503)
           Expenses paid with stock                                                       535            341
           Stock-based compensation expense                                               160             91
           Loss on disposition of fixed assets                                              5             --
      Change in operating assets and liabilities:
           Interest receivable included in short-term and long-term investments            71            211
           Accounts receivable                                                           (224)           (56)
           Prepaids                                                                      (324)          (163)
           Other current receivables                                                      418            271
           Receivable from Encysive, L.P.                                                  --            393
           Accounts payable and accrued expenses                                        1,141            302
           Payable to Encysive, L.P.                                                       --         (5,051)
           Deferred revenue from unrelated parties                                       (280)          (463)
           Deferred revenue from related party                                             --           (135)
                                                                                     --------       --------
            Net cash used in operating activities                                     (21,675)       (12,591)
                                                                                     --------       --------
CASH FLOWS FROM INVESTING ACTIVITIES:

    Purchases of equipment and leasehold improvements                                    (460)          (114)
    Grant received for purchases of equipment                                              --            185
    Purchase of in-process research and development                                        --         (4,000)
    Purchases of investments                                                          (25,924)        (9,756)
    Maturity of investments                                                            11,969         30,578
                                                                                     --------       --------
            Net cash (used in) provided by investing activities                       (14,415)        16,893
                                                                                     --------       --------
CASH FLOWS FROM FINANCING ACTIVITIES:
    Proceeds from sale of common stock and option and
      warrant exercises, net                                                            3,165            126
    Repayment of long-term debt                                                        (6,000)            --
                                                                                     --------       --------
            Net cash (used in) provided by financing activities                        (2,835)           126

Effect of exchange rate changes on cash                                                   152             42
                                                                                     --------       --------
            Net (decrease) increase in cash and cash equivalents                      (38,773)         4,470

Cash and cash equivalents at beginning of period                                       65,302         21,228
                                                                                     --------       --------
Cash and cash equivalents at end of period                                           $ 26,529       $ 25,698
                                                                                     ========       ========
Supplemental schedule of noncash financing activities:
    Stock-based compensation expense                                                 $    160       $     91
    Issuance of Common Stock for expenses                                                 535            341
    Interest paid                                                                          39             --
</TABLE>

           See accompanying notes to consolidated financial statements

                                       3
<PAGE>
                 ENCYSIVE PHARMACEUTICALS INC. AND SUBSIDIARIES
                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

                            JUNE 30, 2004 (UNAUDITED)

(1)   BASIS OF PRESENTATION

      The accompanying unaudited consolidated financial statements of Encysive
Pharmaceuticals Inc., a Delaware corporation, and its subsidiaries (collectively
referred to as the "Company" or "Encysive") have been prepared in accordance
with accounting principles generally accepted in the United States of America
("USA") for interim financial information and with the instructions to Form 10-Q
and Rule 10-01 of Regulation S-X. They do not include all information and notes
required by accounting principles generally accepted in the USA for complete
financial statements. It is recommended that these interim condensed
consolidated financial statements be read in conjunction with the consolidated
financial statements and notes thereto included in the Company's Annual Report
on Form 10-K for the year ended December 31, 2003. Except as disclosed herein,
there has been no material change in the information disclosed in the notes to
the consolidated financial statements included in the Company's Annual Report on
Form 10-K for the year ended December 31, 2003. In the opinion of management,
all adjustments (consisting only of normal recurring accruals) considered
necessary for a fair presentation have been included. Operating results for the
three and six-month periods ended June 30, 2004, are not necessarily indicative
of the results that may be expected for any other interim period, or for the
year ending December 31, 2004.

(2)   ORGANIZATION AND SIGNIFICANT ACCOUNTING POLICIES

      (a) Organization

            Encysive is a biopharmaceutical company focused on the discovery,
      development and commercialization of novel synthetic small molecule
      compounds for the treatment of a variety of cardiovascular, vascular and
      related inflammatory diseases. Since its formation in 1989, the Company
      has been engaged principally in research and drug discovery programs and
      clinical development of certain drug compounds.

            The Company is presently working on a number of long-term
      development projects that involve experimental and unproven technology,
      which may require many years and substantial expenditures to complete, and
      which may or may not be successful. Sales of the Company's first
      FDA-approved product, for which it receives royalty income, Argatroban,
      began during November 2000.

      (b) Basis of Consolidation

            The Company's consolidated financial statements include the accounts
      of the Company, its wholly owned subsidiaries, ImmunoPharmaceutics, Inc.
      ("IPI"), a California corporation, Encysive, L.P. ("ELP"), a Delaware
      limited partnership, EP-ET, LLP, a Delaware limited partnership, Encysive
      (UK) Limited, a private company located in the United Kingdom (UK), and
      its majority controlled subsidiary, Revotar Biopharmaceuticals AG
      ("Revotar"), a German corporation. All material intercompany balances and
      transactions have been eliminated.

      (c) Stock-Based Compensation

            At June 30, 2004, the Company has six stock-based compensation plans
      for employees and non-employee directors. The Company accounts for those
      plans under the recognition and measurement principles of Accounting
      Principles Board Opinion No. 25, "Accounting for Stock Issued to
      Employees," and related interpretations. The Company's results of
      operations for the three-month periods ended June 30, 2004 and 2003, and
      the six-month periods ended June 30, 2004 and 2003, included $93,000 and
      $75,000, respectively, and $160,000 and $91,000, respectively, in
      stock-based compensation expense arising from the grant of shares of
      restricted common stock to employees and the recognition of deferred
      compensation expense arising from the grant of stock options in March

                                       4
<PAGE>
      2003 to certain employees, which were subject to the approval of
      stockholders of an amendment to increase the authorized shares in the 1999
      plan. No other stock-based employee compensation expense is reflected in
      net loss, however, as all options granted under those plans had an
      exercise price equal to the market price of the underlying Common Stock on
      the date of grant. The following table illustrates the effect on net loss
      and loss per share if the Company had applied the fair value recognition
      provisions of FASB Statement of Financial Accounting Standards No. 123,
      "Accounting for Stock-Based Compensation," to stock-based employee
      compensation (dollars in thousands, except for per share data).

<TABLE>
<CAPTION>
                                              Three Months Ended           Six Months Ended
                                                     June 30,                   June 30,
                                                     --------                   --------
                                               2004           2003         2004          2003
                                               ----           ----         ----          ----
<S>                                          <C>           <C>           <C>          <C>
     Net loss, as reported                   $(12,306)     $(14,120)     $(23,427)    $(19,100)

     Add:  Stock-based employee
           compensation expense
           included in reported
           Net loss                                93            75          160            91

     Deduct:  Total stock-based
           employee compensation
           expense determined
           under fair value method
           for all awards                        (984)         (760)       (1,588)      (1,874)
                                             --------      --------      --------     --------
     Pro forma net loss                      $(13,197)     $(14,805)     $(24,855)    $(20,883)
                                             ========      ========      ========     ========

     Loss per share:
           As reported, basic and
           diluted                           $  (0.23)     $  (0.32)     $  (0.45)    $  (0.44)
           Pro forma, basic and diluted      $  (0.25)     $  (0.34)     $  (0.47)    $  (0.48)
</TABLE>

            The per-share weighted average fair value of stock options granted
      during the three-month periods ended June 30, 2004 and 2003, was $5.98 and
      $1.71, respectively, and in the six-month periods ended June 30, 2004 and
      2003 was $5.99 and $0.76, respectively, on the grant date using the
      Black-Scholes option pricing model with the following assumptions:

<TABLE>
<CAPTION>
                                    Three Months Ended     Six Months Ended
                                         June 30,              June 30,
                                         --------              --------
                                     2004        2003      2004        2003
                                     ----        ----      ----        ----
<S>                                 <C>          <C>       <C>        <C>
       Expected dividend yield        0.0%        0.0%      0.0%       0.0%
       Risk-free interest rate        3.9%        2.6%      2.8%       2.5%
       Expected volatility           70.7%       79.8%     73.9%      73.4%
       Expected life in years         5.10        5.50      4.84       4.49
</TABLE>

(3)   CAPITAL STOCK

      The Company has reserved Common Stock for issuance as of June 30, 2004, as
follows:

<TABLE>
<S>                                                        <C>
           Stock option plans......................          7,910,423
           Warrants outstanding....................            142,858
                                                           -----------
                 Total shares reserved.............          8,053,281
</TABLE>

      At June 30, 2004, the Company's only outstanding warrant is a warrant to
purchase 142,858 shares issued to Genentech in 1997. The Genentech warrant
expires in October 2004 and has an exercise price of $14.00 per share.

                                       5
<PAGE>
(4)   CASH, CASH EQUIVALENTS, SHORT-TERM INVESTMENTS AND LONG-TERM INVESTMENTS

      Cash equivalents are considered to be those securities or instruments with
original maturities, when purchased, of three months or less and are recorded at
cost. Short-term investments consist of debt securities with original maturities
of less than one year and greater than three months at the purchase date.
Long-term investments consist of debt securities with a remaining maturity of
one to four years. The Company classifies all short-term and long-term
investments as held-to-maturity. Held-to-maturity securities are those
securities in which the Company has the ability and intent to hold the security
until maturity. Short-term and long-term investments are stated at amortized
cost plus accrued interest. Interest income is accrued as earned. The Company
evaluates the carrying value of its securities by comparing the carrying values
of the securities to their market values. In the event that the fair value of a
security were to decline below its carrying cost, and in the opinion of
management such decline was other than temporary, the Company would record a
loss and reduce the carrying value of such security to its fair value. The
Company has classified as restricted, cash deposited with a bank as security for
certain foreign exchange futures contracts. Composition of cash and investments
was as follows (dollars in thousands):

<TABLE>
<CAPTION>
                                         June 30, 2004      December 31, 2003
                                         -------------      -----------------
<S>                                      <C>                <C>
Cash and cash equivalents:
     Demand and money market accounts       $  1,447            $   1,043
     Corporate commercial paper               25,082               64,259
                                            --------            ---------
Total cash and cash equivalents             $ 26,529            $  65,302
                                            ========            =========

</TABLE>

Investments at June 30, 2004, and December 31, 2003, were as follows (dollars in
thousands):

<TABLE>
<CAPTION>
                                                            As of June 30, 2004
                                                            -------------------
                                                            Gross          Gross        Estimated
       Short-term investments              Amortized     Unrealized      Unrealized        Fair
       Held-to-maturity                       Cost         Gains           Losses         Value
       ----------------                       ----         -----           ------         -----
<S>                                        <C>           <C>             <C>            <C>
       Corporate commercial paper and
       loan participations                   $27,981         $ 36          $ (35)        $27,982

       Corporate debt securities               4,083           --            (72)          4,011
                                             -------         ----          -----         -------
       Total short-term
       held-to-maturity investments          $32,064         $ 36          $(107)        $31,993
                                             =======         ====          =====         =======
</TABLE>

<TABLE>
<CAPTION>
                                                             As of June 30, 2004
                                                             -------------------
                                                            Gross             Gross      Estimated
       Long-term investments                  Amortized   Unrealized       Unrealized      Fair
       Held-to-maturity                          Cost       Gains            Losses        Value
       ----------------                          ----       -----            ------        -----
<S>                                           <C>         <C>              <C>           <C>
       U.S. Government agency securities
                                               $2,006        $ --            $(20)         $1,986
                                               ------        ----            ----          ------
       Total long-term
       held-to-maturity investments            $2,006        $ --            $(20)         $1,986
                                               ======        ====            ====          ======
</TABLE>

                                       6
<PAGE>
<TABLE>
<CAPTION>
                                                            As of December 31, 2003
                                                            -----------------------
                                                              Gross        Gross      Estimated
       Short-term investments                 Amortized    Unrealized    Unrealized     Fair
       Held-to-maturity                          Cost         Gains        Losses       Value
       ----------------                          ----         -----        ------       -----
<S>                                           <C>          <C>           <C>          <C>
       U.S. Government agency securities        $ 2,010       $ --         $  (9)      $ 2,001

       Corporate commercial paper                10,057         19            (2)       10,074

       Corporate debt securities                  6,162         --           (61)        6,101
                                                -------       ----         -----       -------
       Total short-term
       held-to-maturity investments             $18,229       $ 19         $ (72)      $18,176
                                                =======       ====         =====       =======
</TABLE>

<TABLE>
<CAPTION>
                                                         As of December 31, 2003
                                                         -----------------------
                                                           Gross           Gross       Estimated
       Long-term investments               Amortized     Unrealized      Unrealized       Fair
       Held-to-maturity                       Cost         Gains           Losses         Value
       ----------------                       ----         -----           ------         -----
<S>                                        <C>           <C>             <C>           <C>
       Corporate commercial paper             $  956         $ 36           $ --         $  992

       Corporate debt securities               1,001           --             (1)         1,000
                                              ------         ----           ----         ------
       Total long-term
       held-to-maturity investments           $1,957         $ 36           $ (1)        $1,992
                                              ======         ====           ====         ======
</TABLE>

(5)   NET LOSS PER COMMON SHARE

      Basic net loss per common share is calculated by dividing the net loss by
the weighted average number of common and common equivalent shares outstanding
during the period. For the three- and six-month periods ended June 30, 2004, the
weighted average common shares used to compute basic and diluted net loss per
common share totaled 52,549,921 and 52,364,026, respectively. For the three- and
six-month periods ended June 30, 2003, the weighted average common shares used
to compute basic and diluted net loss per common share totaled 43,763,903 and
43,744,573, respectively. Securities convertible into Common Stock comprised of
stock options, warrants and unvested shares of restricted common stock totaling
5,362,912 and 5,844,884 shares at June 30, 2004 and 2003, respectively, were not
used in the calculation of diluted net loss per common share because the effect
would have been antidilutive.

(6)   INCOME TAXES

      The Company did not incur tax expense (benefit) during the three- and
six-month periods ended June 30, 2004 and 2003, due to operating losses and the
related increase in the valuation allowance.

                                       7
<PAGE>
(7)      ENTITY-WIDE GEOGRAPHIC DATA

       The Company operates in a single business segment that includes research
and development of pharmaceutical products. The following table summarizes the
Company's long-lived assets in different geographic locations (dollars in
thousands):

<TABLE>
<CAPTION>
                                      JUNE 30, 2004    DECEMBER 31, 2003
                                      -------------    -----------------
<S>                                   <C>              <C>
     Long-lived assets:
        United States                     $ 4,403          $ 4,327
        Germany                             1,098            1,310
                                          -------          -------
     Total                                $ 5,501          $ 5,637
                                          =======          =======
</TABLE>

      The following table summarizes the Company's revenues in different
geographic locations (dollars in thousands):

<TABLE>
<CAPTION>
                                THREE MONTHS ENDED                 SIX MONTHS ENDED
                                ------------------                 ----------------
                        JUNE 30, 2004     JUNE 30, 2003     JUNE 30, 2004    JUNE 30, 2003
                        -------------     -------------     -------------    -------------
<S>                     <C>               <C>               <C>              <C>
     Revenues:
        United States        $ 2,860         $ 2,086            $ 5,553         $ 5,019
        Germany                  530             142                672             425
                             -------         -------            -------         -------
     Total                   $ 3,390         $ 2,228            $ 6,225         $ 5,444
                             =======         =======            =======         =======
</TABLE>

      The Company's revenues are primarily derived from several entities, each
of whom represents a significant percentage of total revenues. The following
table summarizes the Company's sources of revenues from its principal entities
(dollars in thousands):

<TABLE>
<CAPTION>
                                 THREE MONTHS ENDED             SIX MONTHS ENDED
                                 ------------------             ----------------
                          JUNE 30, 2004   JUNE 30, 2003   JUNE 30, 2004  JUNE 30, 2003
                          -------------   -------------   -------------  -------------
<S>                       <C>             <C>             <C>            <C>
     Entities:
        GSK                    $ 1,960       $ 1,113           $ 3,752      $ 2,261
        Schering-Plough            900           882             1,801        1,764
        Encysive, L.P.              --            --                --          811
        Other                      530           233               672          608
                               -------       -------           -------      -------
     Total                     $ 3,390       $ 2,228           $ 6,225      $ 5,444
                               =======       =======           =======      =======
</TABLE>

(8)   FOREIGN SUBSIDIARY

      The Company owns approximately 55 percent of the outstanding common stock
of Revotar and has consolidated the financial results of Revotar into its
consolidated financial statements. The minority interest in Revotar at June 30,
2004, and December 31, 2003, was $1,085,000 and $1,383,000, respectively. The
Company's consolidated net loss for the three-month periods ended June 30, 2004
and 2003, was reduced by $104,000 and $313,000, respectively, and for the
six-month periods ended June 30, 2004 and 2003, by $298,000 and $503,000,
respectively, for the Revotar minority shareholders' interest in Revotar's
losses.

      Revotar has received research grants from the German government and earned
approximately $530,000 and $142,000 during the three-month periods ended June
30, 2004 and 2003, respectively, which is included in license fees, milestones
and grants. During the six-month periods ended June 30, 2004 and 2003 Revotar
received grants of $672,000 and $425,000, respectively.

      In addition to the research grants discussed above, Revotar has received
grants from the German government to purchase certain research equipment, which
are being recognized in income over the estimated useful life of the assets.

      The Company and the other stockholders of Revotar executed an agreement to
provide approximately $4.5 million in unsecured loans, of which the Company's
commitment was approximately $3.4 million. The terms of the loans require
quarterly interest payments and repayment of all principal on or

                                       8
<PAGE>
before April 1, 2007. The interest rate for the first two years was seven
percent, after which the interest rate will be reset to the U.S. prime rate plus
2.5 percent if such rate is higher than seven percent. Pursuant to such
agreement, the Company has advanced approximately $3.4 million to Revotar as of
June 30, 2004. During 2003, the minority shareholders of Revotar advanced
approximately $1.5 million to Revotar. The loan from the Company is denominated
in U.S. dollars and is eliminated in consolidation. Neither Encysive nor the
minority shareholders have any obligation to advance additional funds to
Revotar.

(9)   LONG-TERM DEBT

      The Company was a party to a note arising from its acquisition of the
partnership interest of ICOS Corporation in ELP in April 2003. The note required
a payment of $4,000,000 on April 22, 2004, and a payment of $2,000,000 on
October 22, 2004. The outstanding principal balance of the note accrued interest
at a rate which approximated the three-month London interbank offering rate for
U.S. dollars ("LIBOR") plus 1.5 percent. The Company's obligations under the
note were secured with an irrevocable standby letter of credit for which the
Company pledged marketable securities with an amortized cost of $7,011,000. On
March 31, 2004, the Company prepaid its remaining $6,000,000 obligation under
the note plus accrued interest of $38,000.

      As of June 30, 2004, Revotar owes its minority shareholders approximately
$1.6 million (see Note 8).

(10)  COMMITMENTS AND CONTINGENCIES

      (a) Foreign Currency Exchange Risk

            The Company is exposed to market risk primarily from changes in
      foreign currency exchange rates.

            The Company has a majority-owned subsidiary in Germany and
      consolidates the results of operations into its consolidated financial
      results. Although not significant to date, the Company's reported assets,
      liabilities, expenses and cash flows from this subsidiary are exposed to
      changing exchange rates. The Company, accordingly, included unrealized
      gains of $185,000 and $106,000, respectively, in its comprehensive loss
      for the three-month periods ended June 30, 2004 and 2003, respectively,
      and unrealized gains of $264,000 and $167,000, respectively, in the
      six-month periods ended June 30, 2004 and 2003. The Company had an
      intercompany receivable from its German subsidiary at June 30, 2004, and
      December 31, 2003; however, this amount is denominated in U.S. dollars and
      is not exposed to exchange risk. Loans by the Company to Revotar are
      denominated in U.S. dollars. The Company contracts with entities in other
      areas outside the U.S. and these transactions are denominated in a foreign
      currency. To date, the currencies of these other countries have not
      fluctuated materially.

      (b) Other contingencies

            Like other biopharmaceutical companies, the Company is subject to
      other contingencies, including legal proceedings and claims arising out of
      its business that cover a wide range of matters, including, among others,
      environmental matters, contract and employment claims, and product
      liability. The Company may be involved in legal actions from time to time.
      The Company has used various substances in its research and development
      that have been or may be deemed to be hazardous or dangerous, and the
      extent of its potential liability, if any, under environmental, product
      liability and workers' compensation statutes, rules, regulations and case
      law is unclear.

                                       9
<PAGE>
ITEM 2.

                 ENCYSIVE PHARMACEUTICALS INC. AND SUBSIDIARIES

         MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND
                              RESULTS OF OPERATIONS

           THREE AND SIX MONTHS ENDED JUNE 30, 2004, AND JUNE 30, 2003

                                    OVERVIEW

      The following discussion of our financial condition and results of
operations should be read in conjunction with our consolidated financial
statements and the related notes to the financial statements included in our
Annual Report on Form 10-K for the year ended December 31, 2003, and with the
consolidated financial statements and related notes to the financial statements
included elsewhere in this Form 10-Q. This discussion contains forward-looking
statements based on current expectations that are subject to risks and
uncertainties, such as statements of our plans, objectives, expectations and
intentions. When used in this discussion, the words "expect," "anticipate,"
"intend," "plan," "believe," "seek," "estimate" and similar expressions are
intended to identify forward-looking statements, although not all
forward-looking statements contain these identifying words. Our actual results
and the timing of events could differ materially from those anticipated or
implied by the forward-looking statements discussed here as a result of various
factors, including, among others, those set forth under the "Cautionary Note
Regarding Forward-Looking Statements" in our Annual Report on Form 10-K for the
year ended December 31, 2003. You should not place undue reliance on these
forward-looking statements, which speak only as of the date of this report.
Except as required by law, we undertake no obligation to update any of the
forward-looking statements in this discussion after the date of this report.

      Encysive is a biopharmaceutical company engaged in the discovery,
development and commercialization of novel, synthetic, small molecule compounds
to address unmet medical needs. Our research and development programs are
predominantly focused on the treatment and prevention of interrelated diseases
of the vascular endothelium and exploit our expertise in the area of the
intravascular inflammatory process, referred to as the inflammatory cascade, and
vascular diseases. We have successfully developed one FDA-approved drug,
Argatroban, for the treatment of heparin-induced thrombocytopenia, ("HIT"),
which is marketed by GlaxoSmithKline plc, ("GSK"). Our lead drug candidate,
Thelin(TM) (sitaxsentan sodium) is an endothelin receptor antagonist in Phase
III clinical trials for the treatment of pulmonary arterial hypertension
("PAH"). In addition, we have earlier stage clinical product candidates in
development including TBC3711, a next generation endothelin receptor antagonist,
and bimosiamose, being developed by our majority-owned German affiliate,
Revotar.

Thelin(TM)

      Thelin(TM) is being developed as a treatment for PAH, a life-threatening
disease characterized by the constriction of blood vessels leading to the lungs.
This constriction leads to very high blood pressure in the pulmonary arteries as
the heart struggles to pump blood to the lungs. PAH patients suffer from extreme
shortness of breath and, as the disease progresses, are less able to perform the
daily activities of living. Over time, PAH leads to right ventricular failure
(heart failure) and death. PAH may be a primary condition, perhaps caused by
genetic factors, or secondary to other diseases like autoimmune diseases (such
as scleroderma or lupus), congenital heart disease, HIV infection or cirrhosis
of the liver. PAH is an orphan disease (defined in the U.S. as a prevalence of
less than 200,000 patients) that industry research analysts estimate to afflict
approximately 80,000 to 100,000 individuals worldwide, many of whom are children
and young women.

      In 2002, we successfully completed and announced results of our
Sitaxsentan To Relieve ImpaireD Exercise in Pulmonary Arterial Hypertension
("STRIDE") 1 Phase IIb/III pivotal study in PAH with Thelin(TM). We have
initiated and are currently enrolling a Phase III pivotal clinical trial, STRIDE
2. In June 2003, we received a Special Protocol Assessment ("SPA"), which is a
binding written agreement between a clinical trial sponsor and the FDA on the
design of pivotal trials, confirming that, if successful,

                                       10
<PAGE>
the STRIDE 2 trial results, together with the results from STRIDE 1 and planned
supportive trials, will be sufficient for the submission to the FDA of
Thelin(TM)'s New Drug Application ("NDA").

      STRIDE 2 is a 240-patient trial enrolling patients with Class II-IV PAH,
as classified by the World Health Organization ("WHO"), of primary or secondary
causes. STRIDE 2 is of 18 weeks duration and tests two doses of Thelin(TM) (100
mg and 50 mg), versus placebo, dosed once daily in a double-blind fashion. In
addition, a randomized bosentan arm is included. A total of 50 to 70 centers
worldwide will participate. The primary endpoint of STRIDE 2 is six-minute walk
distance, and secondary endpoints include change in functional class, shortness
of breath and the occurrence of clinical deterioration events. We anticipate
that we will complete patient enrollment during the third quarter, and we
anticipate that the NDA will be submitted to the Food and Drug Administration on
or around the end of the first quarter in 2005.

      In June 2004, we completed enrollment of patients in STRIDE-6, a
randomized double-blind safety and efficacy study of Thelin(TM) in patients with
PAH who have failed bosentan therapy. We expect top-line clinical data will be
available in the fourth quarter of 2004. In July 2004, we announced that
enrollment had closed in STRIDE-4, a Phase III, randomized, double-blind,
placebo- controlled safety and efficacy study of Thelin(TM) treatments in
patients with PAH.

      We have worldwide commercialization rights to Thelin(TM). Upon regulatory
approval, we intend to commercialize Thelin(TM) in North America through our own
specialty sales force. Although we had previously announced our intention to
seek a marketing partner for the rest of the world, in June 2004, we announced
our intention to reserve all marketing rights to Thelin(TM). We believe it is
advantageous to allow the market to continue to grow globally before making a
final decision on any marketing plans outside North America. While we are
considering the option of marketing the product on our own worldwide, we intend
to leave our options open and continually re-assess the situation as we move
closer to commercialization.

Argatroban

      Argatroban, licensed from Mitsubishi Pharma Corporation ("Mitsubishi") and
developed in North America by Encysive, is a synthetic direct thrombin inhibitor
approved by the FDA in 2000. It is indicated for prophylaxis or treatment of
thrombosis for patients with HIT, a profound allergic reaction to
anticoagulation therapy with heparin, and for use in HIT patients undergoing
precutaneous coronary intervention. Argatroban was approved in Canada in 2002
for use as an anticoagulant therapy in patients with HIT syndrome. GSK markets
Argatroban in the U.S. and Canada, and has Waxman Hatch market exclusivity in
the U.S. until June 2005. A pediatric study is underway, which could prolong
exclusivity in the U.S. to the end of 2005. In fiscal year 2003, Encysive earned
royalties from the sales of Argatroban totaling $5.4 million and expects to earn
royalties of $7.5 to $8.5 million in fiscal year 2004.

Other Development Programs

      In addition to Thelin(TM) and Argatroban, we have a number of projects in
clinical and preclinical development. TBC3711, a next generation ET(A) receptor
antagonist, has completed Phase I clinical development for the treatment of PAH.
TBC3711 is more selective and more potent than Thelin(TM).

      Our majority-owned German affiliate, Revotar, is developing bimosiamose, a
selectin antagonist discovered in Encysive's laboratories, which is designed to
block inflammatory cells from leaving the vascular space to travel to tissue
sites of inflammation. Revotar recently completed Phase IIa clinical trials
evaluating the use of topical bimosiamose for the treatment of psoriasis and
atopic dermatitis. An inhaled version of bimosiamose has completed a 12-patient
proof-of-concept study in asthma that demonstrated a statistically significant
improvement in the late asthmatic response, the same target addressed by inhaled
steroid use in asthma. Revotar is seeking a licensing partner for inhaled
bimosiamose.

       We have entered into a worldwide research collaboration and license
agreement with Schering-Plough Corporation and Schering-Plough LTD (collectively
"Schering-Plough"), to discover, develop and commercialize VLA-4 antagonists.
Schering-Plough is in the final stages of pre-clinical development with

                                       11
<PAGE>
TBC4746, an oral VLA-4 antagonist. If this work is successful, the next
development step would be to initiate studies in human volunteers. VLA-4 is a
potential target in the inflammatory cascade taking place within the
vasculature. TBC4746 has the potential to address a number of diseases,
including asthma and multiple sclerosis. Additionally, Schering-Plough has also
funded research on a follow-on compound pursuant to the research agreement and
such funding ended on June 30, 2004.

Encysive's Research Programs

      Our research efforts are concentrated on targets within the vasculature,
and the potential indications of our drug candidates include cardiovascular
diseases and a potentially wide variety of inflammatory diseases involving two
complementary sets of targets. The first set of targets relate to vascular
G-protein coupled receptors ("GPCRs"). Historically, GPCRs have been some of the
most amenable targets for developing commercially successful pharmaceuticals,
such as beta-blockers, antihistamines, and most anti-psychotics and
anti-depressants. Endothelin receptors, targeted by Thelin(TM) and TBC3711, are
examples of GPCRs.

      Encysive also has developed expertise in pharmacologically intervening in
the intravascular inflammatory cascade, representing a second set of
intravascular targets. Bimosiamose and TBC4746 are examples of drug candidates
that we designed to target two distinct steps in this cascade, the selectins and
VLA-4, respectively. Some of the targets in this cascade are GPCRs. Thus, our
focus on endothelial cell and related vascular biology has opened up a broad
range of disease targets with high, unmet medical need.

CRITICAL ACCOUNTING POLICIES

Revenue Recognition

      -     We recognize revenue from service contracts as services are
            performed.

      -     Royalty revenue is recognized as products are sold by a licensee and
            we have received sufficient information to record a receivable. Our
            royalty revenue is based on net sales of product, that is, sales net
            of discounts, returns and allowances. We have estimated a percentage
            of gross sales, based on recent experience, as an allowance for
            future returns, however there can be no assurance that our estimate
            will be accurate. We believe, however, that differences between
            estimated and actual future returns will not have a material effect
            upon our results of operations or financial condition.

      -     Revenue from collaborative research and development activities is
            recognized as services are performed.

      -     We defer the recognition of milestone payments related to
            contractual agreements that are still in the development stage. Such
            deferred revenues are amortized into income over the estimated
            remaining development period. Milestone payments received under
            contractual agreements that have completed the development stage are
            evaluated and either recognized into income when earned or amortized
            over a future period depending upon whether or not the Company
            continues to have obligations under the terms of the arrangement.

      -     License fees received under the terms of licensing agreements for
            our intellectual property are similarly deferred and amortized into
            income over the estimated developmental period of the licensed item
            or items.

      -     Revenue from grants is recognized as earned under the terms of the
            related grant agreements, typically as expenses are incurred.

      Amounts received in advance of services being performed under contracts
are recorded as deferred revenue and recognized as services are performed. We
periodically evaluate our estimates of remaining development periods and adjust
the recognition of remaining deferred revenues over the adjusted development
period remaining. At June 30, 2004, remaining deferred revenue was approximately
$2.0 million, of which we expect to recognize approximately $0.6 million over
the next twelve months. A future change in our estimate of development periods
could accelerate or decelerate the timing of future recognition of deferred
revenue.

                                       12
<PAGE>
Stock Options

      We apply Accounting Principles Board Opinion No. 25, "Accounting for Stock
Issued to Employees," and related interpretations ("APB 25") in accounting for
our stock option plans and apply FASB Statement No. 123, "Accounting for
Stock-Based Compensation," and related interpretations ("FAS 123") in reporting
for our stock option plans. APB 25 utilizes the "intrinsic value" of stock
options, defined as the difference between the exercise price of an option and
the market price of the underlying share of common stock on the "measurement
date," which is generally the date of grant. Since the exercise price of
employee stock options issued under our plans is set to match the market price
of our Common Stock, there is generally no compensation expense recognized upon
grant of employee stock options. Options granted to non-employees, if any, are
valued at the fair value of the option, as defined by FAS 123, utilizing the
Black-Scholes option pricing model. We record compensation expense for the fair
value of options granted to non-employees. The pro forma effect of recognizing
the fair value of stock option grants to employees on our consolidated results
of operations is discussed in Note 2(c), Stock-Based Compensation.

Drug Manufacturing and Packaging

      Costs arising from the manufacturing and packaging of drug product, which
is intended for use in clinical trials, are recognized as incurred and included
in research and development expenses.

                              RESULTS OF OPERATIONS

      The preparation of financial statements in conformity with accounting
principles generally accepted in the USA requires us to make estimates and
assumptions that affect the reported amounts of assets, liabilities, disclosures
of contingent assets and liabilities at the date of the financial statements and
the reported amounts of revenues and expenses during the reporting period. Our
operating results have fluctuated significantly during each quarter and year and
we anticipate that such fluctuations, which are largely attributable to varying
research and development commitments and expenditures, will continue for the
next several years. We have been unprofitable to date and expect to incur
substantial operating losses for the next several years as we invest in product
research and development, preclinical and clinical testing and regulatory
compliance. We have sustained net losses of approximately $206.4 million from
the date of our inception to June 30, 2004. We have primarily financed our
operations to date through a series of private placements and public offerings
of our common stock and several collaborative agreements with third parties to
jointly pursue product research and development. See "Liquidity and Capital
Resources" below. See also "Additional Risk Factors" in Item 1 "Business" in our
Annual Report on Form 10-K for the year ended December 31, 2003.

      In April 2003, we acquired the interest of ICOS Corporation in ELP in a
transaction also referred to as the "Acquisition." Of the $10 million purchase
price, $4 million was paid at closing and the remaining $6 million was subject
to the terms of a note to ICOS, which required a $4 million payment in April
2004 and a $2 million payment in October 2004. The Company prepaid its remaining
$6 million obligation under the note on March 31, 2004.

      From its inception in June 2000 through December 31, 2002, we and ICOS
shared equally in the costs of ELP. ICOS informed us, however, that it had
reached the conclusion that joint development of the endothelin receptor
antagonist program through ELP should not continue. As a result, from January
2003 until the Acquisition, we agreed to be responsible for 100 percent of the
costs of ELP under the terms of a letter agreement, which expired upon the
Acquisition.

      From its inception in June 2000 through March 31, 2003, we accounted for
our investment in ELP under the equity method. As a result of the Acquisition,
we now include the accounts of ELP in our consolidated financial statements. The
consolidation of ELP into our financial statements results in the elimination of
the revenue item, "Collaborative research and development from Encysive, L.P.,"
and the expense item, "Equity in loss of Encysive, L.P.," from our financial
statements and the inclusion of operating expenses of ELP in our operating
expenses.

                                       13
<PAGE>
            THREE- AND SIX-MONTH PERIODS ENDED JUNE 30, 2004 AND 2003

REVENUES

      Total revenues increased $1.2 million in the three months ended June 30,
2004, compared with the three months ended June 30, 2003. Of the increase, $0.8
million is due to increased royalties on sales of Argatroban by GSK. The
remaining increase is primarily attributable to increased grant revenues at
Revotar.

      Total revenues increased $0.8 million to $6.2 million in the six months
ended June 30, 2004, from $5.4 million in the six months ended June 30, 2003.
Royalties on sales of Argatroban by GSK increased $1.5 million due to higher
sales in the current year period. Revenues in the six-months ended June 30,
2003, however, included $0.7 million of collaborative research and development
from ELP. As discussed above, in the periods following the Acquisition, the
operating results of ELP are included in our operating results and, accordingly,
collaborative research and development from ELP and certain license fee and
milestone revenues have been eliminated in consolidation. Revenues in the three-
and six-month periods ended June 30, 2004, and June 30, 2003, included research
funding from Schering-Plough; such funding ended on June 30, 2004.

RESEARCH AND DEVELOPMENT EXPENSE

      Research and development expense in the three-month period ended June 30,
2004, increased $6.9 million, compared with the three months ended June 30,
2003, primarily due to the costs associated with the ongoing Thelin(TM)
development program. Thelin(TM) development costs increased $6.6 million in the
current quarter, compared to the quarter ended June 30, 2003.

      Research and development expense in the six-month period ended June 30,
2004, increased $14.7 million, compared with the six months ended June 30, 2003,
primarily due to expenses of the Thelin(TM) development program. Of the
increase, $14.6 million is attributable to the Thelin(TM) development program.

      We anticipate that we will complete patient enrollment during the third
quarter and anticipate that the NDA will be submitted to the FDA on or around
the end of the first quarter of 2005. Accordingly, we expect research and
development expenses for the remainder of 2004 to significantly exceed expenses
incurred in the comparable prior-year periods.

GENERAL AND ADMINISTRATIVE EXPENSE

      General and administrative expense in the three months ended June 30, 2004
and 2003, was $2.7 million and $2.3 million, respectively. In the six months
ended June 30, 2004, general and administrative expense was $5.2 million,
compared with $4.4 million in the six months ended June 30, 2003. The increase
in general and administrative expense in the current year periods is primarily
due to costs associated with our preparation for the future commercialization of
Thelin(TM). We believe general and administrative expense throughout the
remainder of 2004 will continue to be higher than in the comparable 2003
periods, due to costs of preparing for the commercialization of Thelin(TM) in
anticipation of receiving regulatory approval.

EQUITY IN LOSS OF ENCYSIVE, L.P.

      As discussed above, prior to the Acquisition we accounted for our
investment in Encysive, L.P. using the equity method, and recorded our share of
its loss as "Equity in Loss of Encysive, L.P." In the periods following the
Acquisition, the expenses of ELP are included in our consolidated results of
operations.

                                       14
<PAGE>
PURCHASE OF IN-PROCESS RESEARCH AND DEVELOPMENT

      The results of the three- and six-month periods ended June 30, 2003,
included a charge of $8.4 million resulting from the Acquisition.

TOTAL OPERATING EXPENSE

      Total operating expense in the three months ended June 30, 2004, decreased
$1.0 million compared to the three months ended June 30, 2003. As discussed
above, however, the three months ended June 30, 2003, includes a charge of $8.4
million from the Acquisition. After taking the Acquisition into consideration,
operating expenses in the three months ended June 30, 2004, increased $7.4
million, compared with the three months ended June 30, 2003.

      Total operating expenses in the six months ended June 30, 2004, increased
$4.8 million compared with the six months ended June 30, 2003. After adjusting
for the costs of the Acquisition, operating expenses increased $13.1 million in
the six months ended June 30, 2004. The increase in the three- and six-month
periods is attributable to costs associated with the Thelin(TM) development
program. As discussed above, we believe that operating expense in the remainder
of 2004 will continue to be higher than the comparable 2003 periods primarily
due to costs associated with the Thelin(TM) development and commercialization.

OPERATING LOSS

      Operating loss in the three months ended June 30, 2004, decreased $2.2
million compared with the three months ended June 30, 2003; however, after
taking the costs associated with the Acquisition into consideration, operating
loss in the three months ended June 30, 2004, increased $6.2 million, primarily
due to the costs associated with the Thelin(TM) program, discussed above,
partially offset by higher revenues in the current year period.

      Operating loss in the six months ended June 30, 2004, increased $4.0
million compared to the six months ended June 30, 2003. After adjusting for the
$8.4 million charge resulting from the Acquisition, operating loss in the six
months ended June 30, 2004, increased $12.3 million. The increased loss is due
to increased research and development costs related to the Thelin(TM)
development program, partially offset by higher revenues in the current year
period.

      As discussed above, we expect operating losses throughout the remainder of
2004 to exceed comparable periods in 2003 due to costs associated with the
Thelin(TM) development and commercialization.

INVESTMENT INCOME

      Investment income in the three and six months ended June 30, 2004,
declined $129,000 and $152,000, respectively, compared to the three and
six months ended June 30, 2003. The decline is primarily due to lower market
interest rates during the current year three- and six-month periods.

                         LIQUIDITY AND CAPITAL RESOURCES

      We have financed our research and development activities and other
operations primarily through public and private offerings of our Common Stock
and from funds received through our collaborations, research agreements and
partnerships. We also have received royalty revenue from sales of Argatroban.

      Cash, cash equivalents and investments in marketable securities, including
accrued interest thereon, was $60.6 million at June 30, 2004, compared with
$85.5 million at December 31, 2003. We used $21.7 million in cash in operating
activities, during the six months ended June 30, 2004, compared to $12.6 million
during the six months ended June 30, 2003. The primary operating uses of cash in
the 2004 and 2003 periods were to fund our general operating expenses and the
ongoing research and development

                                       15
<PAGE>
programs conducted by Encysive, Revotar and ELP, reduced by cash received from
investment income, milestones, and research payments from our collaborative
partners.

      Investing activities are primarily comprised of our investments in debt
securities. Cash is generated from investing activities when marketable
securities mature, and the resulting cash is utilized primarily to fund
operating activities. Cash used in investing activities during the six months
ended June 30, 2004, was primarily comprised of the investment of funds received
from our public offering of common stock in December 2003 and purchases of
equipment. Cash provided by investing activities during the six months ended
June 30, 2003, was primarily comprised of the maturity of investments, the
proceeds of which were used to fund operating activities.

      Cash used in financing activities of $2.8 million during the six months
ended June 30, 2004, included a payment of $6.0 million to ICOS to repay a note
arising from our acquisition of its partnership interest in ELP, partially
offset by approximately $3.2 million in proceeds from the exercise of employee
stock options.

Material Commitments

      Our material contractual obligations are comprised of (i) amounts borrowed
by Revotar from its minority shareholders (see Note 8), (ii) obligations under
our operating lease agreements and (iii) a contingent obligation to pay the
other party of a research agreement a termination fee in the event that we elect
to terminate the project prior to completion.

      As of June 30, 2004, the Company had contractual obligations as follows ($
in thousands):

<TABLE>
<CAPTION>
                                                     Less than       1-3          4-5       After 5
         Contractual Obligations          Total        1 year       years        years       years
<S>                                     <C>          <C>           <C>           <C>       <C>
             Long-term debt             $   1,557           --     $  1,557          --         --
             Operating leases               4,822    $   1,581        3,241          --         --
             Purchase obligations             600          600           --          --         --
                                        ---------    ---------     --------      ------      -----
             Total                      $   6,979      $ 2,181     $  4,798          --         --
</TABLE>

Outlook for 2004

      Previously, we had announced plans to license rights for marketing
Thelin(TM) outside North America. In June 2004, we announced our intention to
reserve all marketing rights to Thelin(TM). As a result of this change in
strategy, we expect to incur additional development costs, including but not
limited to costs associated with regulatory filings in countries outside North
America. Additionally, during the first six months of 2004, we elected to accept
patients beyond our original expectations in certain of the clinical trials and
added additional human pharmacology studies. Our revised outlook for 2004
expenses, below, reflects such additional Thelin(TM) development costs.

      Royalty revenues during the first six months of 2004 have exceeded our
original expectations, due to higher than expected sales of Argatroban by GSK.
We have, accordingly, revised our expectation for royalty revenues to reflect
more recent trends.

<TABLE>
<CAPTION>
                                                       Original Outlook            Revised Outlook
                                                       ----------------            ---------------
<S>                                                 <C>                         <C>
      Royalties.................................    $6.7.to $7.6 million        $7.5 to $8.5 million
      Revenues (including royalties)............    $9.0.to $10.0 million       $10.0 to $11.0 million
      Expenses (net of Revotar minority
      interest).................................    $55.0 to $58.0 million      $64.0 to $67.0 million
      Investment income.........................    $0.8.to $1.0 million        $0.8 to $1.0 million
      Net loss..................................    $(46.0) to $(48.0) million  $(54.0) to $(57.0) million
      Cash and investments at year end..........    $32.0 to $34.0 million      $25.0 to $27.0 million
</TABLE>

                                       16
<PAGE>
      For a number of reasons discussed elsewhere in this Form 10-Q, we cannot
estimate, with a reasonable degree of certainty, total completion costs or
dates of completion of our ongoing research and development projects. See also
"Additional Risk Factors" in Item 1 "Business" in our Annual Report on Form 10-K
for the year ended December 31, 2003, and "Longer-Term Outlook," below.

      These expectations are based upon various assumptions, which are subject
to certain risks, trends and uncertainties that could cause actual results to
differ materially from those projected. Among these risks, trends and
uncertainties are timing and cost of our clinical trials, attainment of research
and clinical goals and milestones of product candidates, and sales levels of
Argatroban. Argatroban sales trends during the first six months of 2004 have
been higher than we originally projected, accordingly we have assumed that
recent sales trends of Argatroban over the previous year will continue. While we
do not sell Argatroban, our revenues include a royalty from GSK, which is based
on sales and will, accordingly, vary with sales. Our actual royalty revenues
could vary from our assumptions to the extent that the actual sales of
Argatroban differ from assumed levels.

      Projected revenues contain continued amortization of deferred license fees
and milestones previously received from Schering-Plough, which are being
deferred over the estimated development period of the respective compound or
program. We periodically review our estimates of development periods and actual
recognized revenues could increase or decrease to the extent that we increase or
decrease our estimated development periods. Our original outlook assumed that
funding under the Schering-Plough research agreement would end on June 30, 2004,
and such funding has ended.

      Projected operating expenses are based upon our current expectations for
the year. We have assumed additional staff necessary to prepare for regulatory
filing in the U.S. as well as in the rest of the world. Increased projected
operating expenses also reflect higher overall patient enrollment in some of the
clinical and other supporting trials and additional human pharmacology studies
of Thelin(TM) than was assumed in our original outlook. Our projected expenses
also include basic research efforts on our other programs and levels of
administrative support we believe to be necessary.

      Projected investment income assumes that the rate of return on invested
funds of approximately two percent on an average of approximately $50 million in
funds available for investment throughout the year.

      Cash and investments at year-end are projected based upon our projected
sources and uses of cash during the year. In projecting our end of year cash and
investment balances, we have not assumed additional financing or collaborative
arrangements other than those in place at this time.

      The range of estimated net loss is based upon our projected revenues and
expenses, as discussed above.

Longer-Term Outlook

      We expect to incur substantial research and development expenditures as we
design and develop biopharmaceutical products for the prevention and treatment
of cardiovascular and other interrelated diseases of the vascular endothelium.
We anticipate that our operating expenses will increase in subsequent years
because:

      -     We expect to incur significant expenses in conjunction with
            additional clinical trial costs for Thelin(TM) and research and
            clinical trial costs for development of bimosiamose compounds and
            expect to begin to incur costs for clinical trials related to
            additional compounds. These costs include:

            -     hiring personnel to direct and carry out all operations
                  related to clinical trials;

            -     hospital and procedural costs;

            -     services of a contract research organization; and

            -     purchasing and formulating large quantities of the compound to
                  be used in such trials.

                                       17
<PAGE>
      -     There may be additional costs in future periods related to
            Argatroban in complying with ongoing FDA requirements.

      -     Our administrative costs and costs to commercialize our products
            will increase as our products are further developed and marketed.

      -     If Thelin(TM) receives regulatory approval, we will incur
            significant commercialization expenses.

      We have been unprofitable to date and expect to incur operating losses for
the next several years as we invest in research and development, preclinical and
clinical testing, and regulatory compliance. We will require substantial
additional funding to complete the research and development of our product
candidates, to establish commercial scale manufacturing facilities, if
necessary, and to market our products. Estimates of our future capital
requirements will depend on many factors, including:

      -     market acceptance and commercial success of Argatroban;

      -     expenses and risks associated with clinical trials to expand the
            indications for Thelin(TM);

      -     continued scientific progress in our drug discovery programs;

      -     the magnitude of these programs;

      -     progress with preclinical testing and clinical trials;

      -     the time and costs involved in obtaining regulatory approvals;

      -     the costs involved in filing, prosecuting and enforcing patent
            claims;

      -     competing technological and market developments and changes in our
            existing research relationships;

      -     our ability to maintain and establish additional collaborative
            arrangements; and

      -     effective commercialization activities and arrangements.

      Subject to these factors, we anticipate that our existing capital
resources and other revenue sources should be sufficient to fund our cash
requirements into the second quarter of 2005. Notwithstanding revenues, which
may be produced through sales of potential future products, if approved, we
anticipate that we will need to secure additional funds to continue the required
levels of research and development to reach our long-term goals. We intend to
seek such additional funding through collaborative arrangements and/or through
public or private financings. Upon regulatory approval, we intend to
commercialize Thelin(TM) in North America through our own specialty sales force.
Although we had previously announced our intention to seek a marketing partner
for the rest of the world, in June 2004 we announced our intention to reserve
all marketing rights to Thelin(TM). We believe it is advantageous to allow the
market to continue to grow globally before making a final decision on any
marketing plans outside North America. While we are considering the option of
marketing the product on our own worldwide, we intend to leave our options open
and continually re-assess the situation as we move closer to commercialization.

      In 2002, the stockholders of Revotar executed an agreement to provide
approximately $4.5 million in unsecured loans, of which our commitment was
approximately $3.4 million. Under the loan agreement, we have advanced
approximately $3.4 million to Revotar as of June 30, 2004. Revotar's current
shareholders have no obligation to advance additional funds to Revotar. We
believe that Revotar's existing funds, and the remaining commitment under the
loan agreement and proceeds under German government scientific grants, will be
sufficient to fund Revotar into the first quarter of 2005. In order to continue
to operate beyond that time, Revotar will need to seek additional funding
through collaborative arrangements and/or through public or private financings
in the future. Revotar is actively seeking a partner, or partners, to develop
the inhaled indications of bimosiamose.

                                       18
<PAGE>
Off-Balance Sheet Arrangements

      We do not engage in off-balance sheet financing arrangements.

                     IMPACT OF INFLATION AND CHANGING PRICES

      The pharmaceutical research industry is labor intensive and wages and
related expenses increase in inflationary periods. The lease of space and
related building services for the Houston facility contains a clause that
escalates rent and related services each year based on the increase in building
operating costs and the increase in the Houston Consumer Price Index,
respectively. To date, inflation has not had a significant impact on our
operations.

              CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS

      This Form 10-Q contains forward-looking statements within the meaning of
Section 27A of the Securities Act of 1933 and Section 21E of the Securities
Exchange Act of 1934, as amended (the "Exchange Act"). All statements other than
statements of historical fact included in and incorporated by reference into
this Form 10-Q are forward-looking statements. These forward-looking statements
include, without limitation, statements regarding our estimate of the
sufficiency of our existing capital resources and our ability to raise
additional capital to fund cash requirements for future operations, and
regarding the uncertainties involved in the drug development process and the
timing of regulatory approvals required to market these drugs. Although we
believe that the expectations reflected in these forward-looking statements are
reasonable, we cannot give any assurance that such expectations reflected in
these forward-looking statements will prove to have been correct.

      When used in this Form 10-Q, the words "expect," "anticipate," "intend,"
"plan," "believe," "seek," "estimate" and similar expressions are intended to
identify forward-looking statements, although not all forward-looking statements
contain these identifying words. Because these forward-looking statements
involve risks and uncertainties, actual results could differ materially from
those expressed or implied by these forward-looking statements for a number of
important reasons, including those discussed under "Management's Discussion and
Analysis of Financial Condition and Results of Operations - Liquidity and
Capital Resources."

      You should read these statements carefully because they discuss our
expectations about our future performance, contain projections of our future
operating results or our future financial condition, or state other "forward-
looking" information. Before you invest in our Common Stock, you should be aware
that the occurrence of any of the contingent factors described herein under
"Management's Discussion and Analysis of Financial Condition and Results of
Operations - Liquidity and Capital Resources" and described under "Additional
Risk Factors" in our Annual Report on Form 10-K for the year ended December 31,
2003, could substantially harm our business, results of operations and financial
condition. Upon the occurrence of any of these events, the trading price of our
Common Stock could decline and you could lose all or part of your investment.

      We cannot guarantee any future results, levels of activity, performance or
achievements. Except as required by law, we undertake no obligation to update
any of the forward-looking statements in this Form 10-Q after the date of this
Form 10-Q.

                                       19
<PAGE>
ITEM 3. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

                         FOREIGN CURRENCY EXCHANGE RISK

      We are exposed to market risk primarily from changes in foreign currency
exchange rates. The following describes the nature of this risk that is not
believed to be material to us.

      We have a majority-owned affiliate in Berlin, Germany, and consolidate the
results of operations into our consolidated financial results. Although not
material to date, our reported expenses and cash flows from this affiliate are
exposed to changing exchange rates. We also have contracts with entities in
other areas outside the U.S. that are denominated in a foreign currency. To
date, these currencies have not fluctuated materially.

ITEM 4. CONTROLS AND PROCEDURES

Evaluation of Disclosure Controls and Procedures

      As of the end of the period covered by this report, our management carried
out an evaluation, with the participation of our principal executive officer
(the "CEO") and our principal financial officer (the "CFO"), of the
effectiveness of our disclosure controls and procedures pursuant to Rule 13a-15
of the Securities Exchange Act of 1934. Based on those evaluations, the CEO and
CFO believe:

      (i) that our disclosure controls and procedures are designed to ensure
that information required to be disclosed by us in the reports that we file or
submit under the Securities Exchange Act of 1934 is recorded, processed,
summarized and reported within the time periods specified in the SEC's rules and
forms, and that such information is accumulated and communicated to our
management, including the CEO and CFO, as appropriate to allow timely decisions
regarding required disclosure; and

      (ii) that our disclosure controls and procedures are effective.

Changes in Internal Controls Over Financial Reporting

      There have been no significant changes in our internal controls over
financial reporting during the period covered by this report that has materially
affected, or are reasonably likely to materially affect, our control over
financial reporting.

                                       20
<PAGE>
PART II. OTHER INFORMATION

ITEM 1. LEGAL PROCEEDINGS

      None

ITEM 2. CHANGES IN SECURITIES, USE OF PROCEEDS AND ISSUER PURCHASES OF EQUITY
        SECURITIES

      None.

ITEM 3. DEFAULTS UPON SENIOR SECURITIES

      None

ITEM 4. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

            On May 11, 2004, we held an annual meeting of our stockholders. The
      holders of 42,497,533 shares of common stock were present in person or
      represented by proxy at the meeting. At the meeting, the stockholders took
      the following actions:

      (a) Election of Directors

            The stockholders elected the following persons to serve as directors
      of the Company until the next annual meeting of stockholders, or until
      their successors are duly elected and qualified:

<TABLE>
<CAPTION>
                                             NUMBER OF VOTES     NUMBER OF VOTES
                    NAME OF NOMINEE             VOTED FOR            WITHHELD
                    ---------------             ---------            --------
<S>                                          <C>                 <C>
        Ron J. Anderson, M.D. ..........        41,211,560          1,285,973
        Frank C. Carlucci...............        40,251,185          2,246,348
        Robert J. Cruikshank............        40,489,992          2,007,541
        Richard A. F. Dixon, Ph.D. .....        40,646,933          1,850,600
        Bruce D. Given, M.D. ...........        40,646,033          1,851,500
        Suzanne Oparil, M.D. ...........        40,616,119          1,881,414
        John M. Pietruski...............        40,630,058          1,867,475
        William R. Ringo, Jr. ..........        40,616,024          1,881,509
        James A. Thomson, Ph.D. ........        41,210,960          1,286,573
        James T. Willerson, M.D. .......        38,092,308          4,405,225
</TABLE>

      (b) Adoption of the Amendment to the Amended and Restated 1999 Stock
Incentive Plan

            The result of the vote on the proposed amendment to the 1999 Plan
      was as follows:

<TABLE>
<CAPTION>
      NUMBER OF VOTES    NUMBER OF VOTES     NUMBER OF VOTES       NUMBER OF
         VOTED FOR        VOTED AGAINST        ABSTAINING       BROKER NON-VOTES
         ---------        -------------        ----------       ----------------
<S>                      <C>                 <C>                <C>
        19,362,133          7,838,639            126,589           15,170,172
</TABLE>

ITEM 5. OTHER INFORMATION

      None

                                       21
<PAGE>
ITEM 6. EXHIBITS AND REPORTS ON FORM 8-K

            Five reports on Form 8-K were filed during the quarter ended June
      30, 2004. A report on Form 8-K dated April 29, 2004, was filed regarding
      the Company's first quarter 2004 results. A report on Form 8-K dated May
      24, 2004, was filed regarding the new data on Thelin(TM) presented at the
      American Thoracic Society's International Conference. A report on Form 8-K
      dated June 3, 2004, was filed regarding the Company's update of Ex-North
      American licensing strategy for Thelin. A report on Form 8-K dated June 7,
      2004, was filed regarding the filing of a $150 million universal shelf
      registration statement. A report on Form 8-K dated June 23, 2004, was
      filed regarding the appointment of J. Kevin Buchi to the Board of
      Directors.

<TABLE>
<CAPTION>
     EXHIBIT NO.             DESCRIPTION
     -----------             -----------
<S>                          <C>
       31.1                  Certification of Chief Executive Officer pursuant
                             to Rule 13a-14(a) / Rule 15d-14(a), promulgated
                             under the Securities Exchange Act of 1934, as
                             amended.

       31.2                  Certification of Chief Financial Officer pursuant
                             to Rule 13a-14(a) / Rule 15d-14(a), promulgated
                             under the Securities Exchange Act of 1934, as
                             amended.

       32.1                  Certification Pursuant to 18 U.S.C. Section 1350,
                             as Adopted Pursuant to Section 906 of the
                             Sarbanes-Oxley Act of 2002.

       32.2                  Certification Pursuant to 18 U.S.C. Section 1350,
                             as Adopted Pursuant to Section 906 of the
                             Sarbanes-Oxley Act of 2002.

</TABLE>

                                       22
<PAGE>
                          ENCYSIVE PHARMACEUTICALS INC.

                                  JULY 29, 2004

                                   SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized, on the 29th day of July, 2004.

                              ENCYSIVE PHARMACEUTICALS INC.


                              By:  /s/ Bruce D. Given, M.D.
                                   -----------------------------------------
                                   Bruce D. Given, M.D.
                                   President and Chief Executive Officer




                              By:  /s/ Stephen L. Mueller
                                   ------------------------------------------
                                   Stephen L. Mueller
                                   Vice President, Finance and Administration
                                   Secretary and Treasurer
                                   (Principal Financial and Accounting Officer)

                                       23
<PAGE>
                                INDEX TO EXHIBITS

<TABLE>
<CAPTION>
     EXHIBIT NO.             DESCRIPTION
     -----------             -----------
<S>                          <C>
       31.1                  Certification of Chief Executive Officer pursuant
                             to Rule 13a-14(a) / Rule 15d-14(a), promulgated
                             under the Securities Exchange Act of 1934, as
                             amended.

       31.2                  Certification of Chief Financial Officer pursuant
                             to Rule 13a-14(a) / Rule 15d-14(a), promulgated
                             under the Securities Exchange Act of 1934, as
                             amended.

       32.1                  Certification Pursuant to 18 U.S.C. Section 1350,
                             as Adopted Pursuant to Section 906 of the
                             Sarbanes-Oxley Act of 2002.

       32.2                  Certification Pursuant to 18 U.S.C. Section 1350,
                             as Adopted Pursuant to Section 906 of the
                             Sarbanes-Oxley Act of 2002.
</TABLE>