EXHIBIT 10.16  AMENDMENT TO LEASE Dated
September 1, 2001  This amendment to Lease is entered into this
1st day of September 2001, by and between Ekwill Street, LP a California
limited partnership, hereinafter referred to as Landlord, and McGhan Medical Corporation,
hereinafter referred to as Tenant.  WHEREAS,Landlord and
Tenant entered into that certain Lease Agreement dated July 1, 1985, as
amended, for the premises commonly known as 5511, 5531, 5551 and 5571 Ekwill
Street, Santa Barbara, California.  WHEREAS, the parties desire to amend said
lease as follows:  1.Articles 2, Term:The
term of the above referenced lease is amended as follows:  The lease term for the
building containing 11,200 SF commonly known as 5551 Ekwill Street is hereby
extended for eighteen (18) months.  The
lease termination date is hereby changed to December 31, 2003.  All the lease termination dates pertaining
to 5511, 5531 and 5571 Ekwill Street will remain as specified in the Amendments
to Lease dated December 15, 1999 and May 1, 2001.  2.Articles 10 and 11, Insurance and Taxes:Tenant shall continue to pay all of the costs associated with
property and casualty insurance and property taxes to September 1, 2001. From
September 1, 2001 to January 1, 2002, Tenant shall pay 75% of the above
referenced costs. From January 1, 2002 to July 1, 2002, tenant shall pay 50% of
the above referenced costs. From July 1, 2002 to January 1, 2004, tenant shall
pay 25% of the above referenced costs.  3.Articles 3.1 and 3.2, Minimum Monthly Rent and Rental Adjustment:  A.From July 1,
2001 to September 1, 2001, the minimum monthly base rent will be fifty-eight
thousand ninety four and 68/100 dollars ($58,094.68) per month plus a rent
increase calculated as specified in Article 3.2 of the above referenced lease
as amended;  B.From September
1, 2001 to January 1, 2002, the minimum monthly base rent will be forty-three
thousand five hundred seventy one and 01/100 dollars ($43,571.01);  C.From January 1,
2002 to July 1, 2002, the minimum monthly base rent will be twenty-nine
thousand forty-seven and 34/100 dollars ($29,047.34); and  D.From July 1,
2002 to July 1, 2003, the minimum monthly base rent will be fifteen thousand
six hundred eighty dollars ($15,680.00). From July 1, 2003 to January 1, 2004,
a rent increase calculated as specified in Article 3.2 of the above referenced
lease, as amended, shall be applied to the minimum monthly base rent.  
   4.Prior to
vacating the individual buildings comprising the leased premises, Tenant will
complete the work described in exhibit A attached hereto and included by
reference.  Tenants failure to complete
the work on or before the times described shall constitute a material default
under the lease and upon any such default, Landlord is entitled to (A)
terminate the lease (B) recover as damages the costs incurred by Landlord in
causing such work to be completed. The obligation of the Tenant hereunder shall
survive the termination of the lease.  5.Item one (1) of
Exhibit A of the Amendment to Lease dated December 15, 1999 will be deleted
as it pertains to 5571 Ekwill only. 
Tenant will leave the interior of 5571 Ekwill in broom clean condition
with its current wall partitions and clean room facility left in place.  EXCEPTas set forth
in this Amendment to Lease, all provisions of the original Lease Agreement and
subsequent Lease Amendments will remain unchanged and in full force and effect,
and the parties hereby ratify and confirm said lease as so amended, and agree
to be bound by its terms.  LANDLORD:
  
  TENANT:Ekwill Street, LP
  
  McGhan Medical Corporationa California limited
  partnershipBy
  /s/ James P. Knell
  
  By
  /s/ Nicholas TetiJames P. Knell, General
  Partner
  
  
  Nicholas Teti, President
  and CEODated:
  September 1, 2001
  
  Dated
  Nov. 2, 2001   
   EXHIBIT A  McGhan Medical Corporation (Tenant) is
responsible to perform the work and pay all the costs associated with the
following upon vacating the Property. 
Tenant will complete the work described below (A) not later than August
31, 2001 with respect to the building known as 5571 Ekwill; (B) not later than
December 31, 2001 with respect to the building known as 5531 Ekwill; (C) not
later than June 30, 2002 with respect to the building known as 5511 Ekwill (D)
and not later than December 31, 2003 with respect to the building known as 5551
Ekwill.  All the above referenced
buildings hereinafter shall be known as the Property.  1.             Remove all temporary walls and
partitions constructed at any time during the life of the lease; 2.             Repair, resurface and stripe the
entire parking lot per the previously agreed to specifications; 3.Tear off and
replace the roof covering the manufacturing building located at 5551 Ekwill per
the previously agreed to specifications; 4.Maintain the
landscaping for the Property during the two-year period ending 6 30-2002.
Ekwill Street, LP (Landlord) will contribute towards the cost during the
second year (2) on a pro-rata basis, based upon the ratio between the original
square footage of the leased premises and the square footage of the area being
leased  by the Tenant during the second
year. Landlord will contract with and pay for the landscaper to maintain the
landscaping at the Property from July 1, 2002 forward and Tenant will reimburse
Landlord for 25% of the costs relating to the landscaping from July 1, 2002 to
January 1, 2004. 5.Upon vacating
the Property, leave the interior of the premises in broom clean condition and
clean all of the windows. 6.Landlord will
hire a professional engineering company to perform all of the required
procedures involved in Phase II Environmental testing.  If the tests show no contamination resulting
from the Tenants business practices, than Landlord will pay for the
testing.  If any contamination  is found, Tenant will pay for the tests and
all costs associated with the clean up of the contamination. 7.Any and all
additions to the Property, whether attached to the buildings or free standing,
(fences, additions, storage, signage...), shall be removed and all damage
associated with the removal shall be repaired. 8.Upon move out,
each of the four (4) buildings will contain four (4) operational entry doors
and four (4) fully functioning roll-up doors. 
The entry doors shall be constructed in the same fashion as those on
site during the October 1999 inspection. 
The roll up doors will be constructed in the same fashion as those on
site during the October 1999 inspection. 9.All work must
by performed by a licensed, bonded and insured contractor.  Tenant will obtain all lien releases upon
completion of the required construction . 
All costs relating to the above-described work, unless specified to the
contrary, are the sole responsibility of Tenant.  Tenant agrees to fully indemnify Landlord and all of its affiliates,
against any and all issues that arise from the work performed as a result of
the move-out.  LANDLORD:
  
  TENANT:Ekwill Street, LP
  
  McGhan Medical Corporationa California limited
  partnershipBy
  /s/ James P. Knell
  
  By
  /s/ Nicholas TetiJames P. Knell, General
  Partner
  
  
  Nicholas Teti, President
  and CEODated
  September 1, 2001
  
  Dated
  Nov. 2, 2001