Exhibit 10.1


 





SECURITIES
PURCHASE AGREEMENT


 


This Securities Purchase
Agreement (this “Agreement”) is made as of March 1, 2013, between EntreMed, Inc., a Delaware corporation (the
“Company”), and each purchaser identified on the signature pages hereto (each, including its successors and
assigns, a “Purchaser” and collectively the “Purchasers”).


 


WHEREAS, subject to
the terms and conditions set forth in this Agreement and pursuant to the Registration Statement (as defined below), the Company
desires to issue and sell to each Purchaser, and each Purchaser, severally and not jointly, desires to purchase from the Company,
securities of the Company as described in this Agreement.


 


NOW, THEREFORE, IN
CONSIDERATION of the mutual promises, covenants and conditions contained in this Agreement, and for other good and valuable consideration
the receipt and adequacy of which are hereby acknowledged, the Company and each Purchaser agree as follows:


 


ARTICLE
I.

DEFINITIONS


 


1.1Definitions.
In addition to the terms defined elsewhere in this Agreement, for all purposes of this Agreement, the following terms have the
meanings set forth in this Section 1.1:


 


“Business
Day” means any day except any Saturday, any Sunday, any day which is a federal legal holiday in the United States or
any day on which banking institutions in the State of New York are authorized or required by law or other governmental action to
close.


 


“Closing”
means the closing of the purchase and sale of the Shares and the Warrants pursuant to Section 2.1.


 


“Closing
Date” means the day on which all of the Transaction Documents have been executed and delivered by the applicable parties
thereto, and all conditions precedent to (i) the Purchasers’ obligations to pay the Subscription Amount and (ii) the Company’s
obligations to deliver the Shares and the Warrants, in each case, have been satisfied or waived, but in no event later than the
third Trading Day] following the date hereof.


 


“Commission”
means the United States Securities and Exchange Commission.


 


“Common
Stock” means the common stock of the Company, par value $0.01 per share, and any other class of securities into which
such securities may hereafter be reclassified or changed.


 


“Initial
Exercise Date” means the date that is 181 days after the Closing Date.


 


“Market
Price” means the closing bid price of the Common Stock for the Trading Day immediately preceding the date hereof on the
Trading Market as reported by Bloomberg L.P. (based on a Trading Day close of 4:02 p.m. (New York City time)).


 


“Per
Share Purchase Price” equals $2.40, subject to adjustment for reverse and forward stock splits, stock dividends, stock
combinations and other similar transactions of the Common Stock that occur after the date of this Agreement.


 


“Person”
means an individual or corporation, partnership, trust, incorporated or unincorporated association, joint venture, limited liability
company, joint stock company, government (or an agency or subdivision thereof) or other entity of any kind.


 


“Prospectus”
means the final prospectus filed for the Registration Statement.


 






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“Prospectus
Supplement” means the supplement to the Prospectus complying with Rule 424(b) of the Securities Act that is filed with
the Commission and delivered by the Company to each Purchaser at the Closing.


 


“Registration
Statement” means the effective registration statement under the Securities Act of 1933, as amended (the “Securities
Act”) with Commission File No. 333-184128, which registers the sale of the Shares, the Warrants and the Warrant Shares
by the Purchasers.


 


“Rule
424” means Rule 424 promulgated by the Commission pursuant to the Securities Act, as such Rule may be amended or interpreted
from time to time, or any similar rule or regulation hereafter adopted by the Commission having substantially the same purpose
and effect as such Rule.


 


“Securities”
means the Shares, the Warrants and the Warrant Shares.


 


“Shares”
means the shares of Common Stock issued or issuable to each Purchaser pursuant to this Agreement.


 


“Subscription
Amount” means, as to each Purchaser, the aggregate amount to be paid for the Shares and Warrants purchased hereunder
as specified below such Purchaser’s name on the signature page of this Agreement and next to the heading “Subscription
Amount,” in United States dollars and in immediately available funds.


 


“Trading
Day” means a day on which the principal Trading Market is open for trading.


 


“Trading
Market” means any of the following markets or exchanges on which the Common Stock is listed or quoted for trading on
the date in question: the Nasdaq Capital Market, the Nasdaq Global Market, the Nasdaq Global Select Market, the NYSE MKT or the
New York Stock Exchange (or any successors to any of the foregoing).


 


“Transaction
Documents” means this Agreement, the Warrants and any other documents or agreements executed in connection with the transactions
contemplated hereunder.


 


“Transfer
Agent” means American Stock Transfer & Trust Company, the current transfer agent of the Company, and any successor
transfer agent of the Company.


 


“Warrants”
means, collectively, the Common Stock purchase warrants delivered to the Purchasers at the Closing in accordance with Section 2.2(a)
hereof, which Warrants shall be exercisable beginning from the Initial Exercise Date and have a term of exercise equal to three
years from the Initial Exercise Date, in substantially the form set forth on Exhibit A attached hereto.


 


“Warrant
Shares” means the shares of Common Stock issuable upon exercise of the Warrants.


 


ARTICLE
II.

PURCHASE AND SALE


 


2.1Closing.
On the Closing Date, upon the terms and subject to the conditions set forth herein, substantially concurrent with the execution
and delivery of this Agreement by the parties hereto, the Company agrees to sell, and the Purchasers, severally and not jointly,
agree to purchase, up to an aggregate of $11,000,000 of Shares and Warrants. The Shares and Warrants will be sold together as units,
each unit consisting of 1 share of Common Stock and a Warrant to purchase 0.5 shares of Common Stock. Each Purchaser shall deliver
to the Company, via wire transfer of immediately available funds, the amount equal to such Purchaser’s Subscription Amount
as set forth on the signature page hereto executed by such Purchaser and the Company shall deliver to each Purchaser its respective
Shares and a Warrant as determined pursuant to Sections 2.2(a) and 3.1(e), and the Company and each Purchaser shall deliver the
other items set forth in Section 2.2 deliverable at the Closing. Upon satisfaction of the covenants and conditions set forth in
Sections 2.2 and 2.3, the Closing shall occur at 10:00 a.m. at the offices of Arnold & Porter LLP, 555 Twelfth Street, N.W.,
Washington, D.C. 20005 or such other location as the parties shall mutually agree.


 






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2.2Deliveries.


 


(a)On
or prior to the Closing Date, the Company shall deliver or cause to be delivered to each Purchaser the following:


 


(i)this
Agreement duly executed by the Company;


 


(ii)a
Warrant, registered in the name of such Purchaser, to purchase the number of shares of Common Stock equal to 50% of the number
of Shares to be registered in the name of such Purchaser pursuant to Section 3.1(e) of this Agreement, with an exercise price equal
to $2.91 per share, subject to adjustment therein; and


 


(iii)the
Prospectus and Prospectus Supplement (which may be delivered in accordance with Rule 172 under the Securities Act).


 


(b)On
or prior to the Closing Date, each Purchaser shall deliver or cause to be delivered to the Company the following:


 


(i)this
Agreement duly executed by such Purchaser; and


 


(ii)such
Purchaser’s Subscription Amount by wire transfer to the account as specified in writing by the Company at least three (3)
Business Days prior to the Closing Date or by delivery of immediately available funds.


 


2.3Closing
Conditions. 


 


(a)The
obligations of the Company hereunder in connection with the Closing are subject to the following conditions being met:


 


(i)the
truth and accuracy in all material respects on the Closing Date of the representations and warranties of the Purchasers contained
herein (unless as of a specific date therein);


 


(ii)all
obligations, covenants and agreements of each Purchaser required to be performed at or prior to the Closing Date shall have been
performed or waived; and


 


(iii)the
delivery by each Purchaser of the items set forth in Section 2.2(b) of this Agreement.


 


(b)The
respective obligations of each Purchaser hereunder in connection with the Closing are subject to the following conditions being
met:


 


(i)the
truth and accuracy in all material respects when made and on the Closing Date as if made on the Closing Date of the representations
and warranties of the Company contained herein (unless as of a specific date therein);


 


(ii)all
obligations, covenants and agreements of the Company required to be performed at or prior to the Closing Date shall have been performed
or waived;


 


(iii)the
delivery by the Company of the items set forth in Section 2.2(a) of this Agreement; and


 


(iv)Except
as disclosed in the Prospectus, the Prospectus Supplement and the Offering Information (including any documents incorporated by
reference therein) there shall have been no Material Adverse Effect (as defined below) since September 30, 2012.


 






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ARTICLE
III.

REPRESENTATIONS, WARRANTIES AND COVENANTS


 


3.1Representations
and Warranties of the Company. The Company hereby represents, warrants and covenants
to each Purchaser as follows:


 


(a)The
Company is a corporation, duly organized, validly existing and in good standing under the laws of the State of Delaware. The Company
has full power and authority to conduct its business as presently conducted and is registered or qualified to do business and in
good standing in each jurisdiction in which it owns property or transacts business and where the failure to be so qualified would
have a material adverse effect upon the Company and its subsidiaries as a whole or the business, financial condition, properties,
operations or assets of the Company and its subsidiaries as a whole or the Company’s ability to perform its obligations under
this Agreement and the other Transaction Documents in all material respects (“Material Adverse Effect”), and to the
knowledge of the Company, no proceeding has been instituted in any such jurisdiction revoking, limiting or curtailing, or seeking
to revoke, limit or curtail, such power and authority or qualification.


 


(b)The
Company has all requisite corporate power and authority to execute, deliver and perform its obligations under the Transaction Documents.
The execution and delivery of the this Agreement and the other Transaction Documents and the consummation by the Company of the
transactions contemplated hereby and thereby have been duly authorized by all necessary corporate action and no further action
on the part of the Board of Directors or stockholders is required. Upon execution of the Transaction Documents by the Company,
the Transaction Documents will be validly executed and delivered by the Company and will constitute legal, valid and binding agreements
of the Company enforceable against the Company in accordance with their terms, except as limited by applicable bankruptcy, insolvency,
reorganization, moratorium, fraudulent conveyance, and any other laws of general application affecting enforcement of creditors’
rights generally, and as limited by laws relating to the availability of specific performance, injunctive relief, or other equitable
remedies.


 


(c)The
issuance and sale of each of the Shares and the Warrants have been duly authorized by the Company, and the Shares, when issued
and paid for in accordance with this Agreement, will be duly and validly issued, fully paid and nonassessable. The Warrant Shares
have been duly authorized and reserved for issuance pursuant to the terms of the Warrants, and the Warrant Shares, when issued
by the Company upon valid exercise of the Warrants and payment of the exercise price, will be duly and validly issued, fully paid
and nonassessable. The Company shall, so long as any of the Warrants are outstanding, take all action necessary to reserve and
keep available out of its authorized and unissued capital stock, solely for the purpose of effecting the exercise of the Warrants,
all of the number of Warrant Shares.


 


(b)The
Company will use its reasonable best efforts to maintain the effectiveness of the Registration Statement in accordance with the
rules and regulations promulgated by the Commission.


 


(c)Within
one Business Day of the Closing, the Company shall deliver irrevocable instructions to the Transfer Agent instructing the Transfer
Agent to deliver via the Depository Trust Company Deposit Withdrawal Agent Commission System (“DWAC”), or if
requested, by physical stock certificate as soon as practicable, that number of Shares equal to such Purchaser’s Subscription
Amount divided by the Per Share Purchase Price, registered in the name of such Purchaser.


 






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(d)The
execution and delivery of the Transaction Documents and the sale and issuance of the Securities to be sold by the Company pursuant
to the Transaction Documents, the fulfillment of the terms of the Transaction Documents and the consummation of the transactions
contemplated thereby will not: (i) result in a conflict with or constitute a material violation of, or material default (with the
passage of time or otherwise) under, (A) any bond, debenture, note, loan agreement or other evidence of indebtedness, or any material
lease or contract to which the Company is a party or by which the Company or their respective properties are bound, (B) the Certificate
of Incorporation, by-laws or other organizational documents of the Company, as amended, or (C) any law, administrative regulation,
or existing order of any court or governmental agency, or other authority binding upon the Company or the Company’s respective
properties; or, (ii) result in the creation or imposition of any lien, encumbrance, claim or security interest upon any of the
material assets of the Company or an acceleration of indebtedness pursuant to any obligation, agreement or condition contained
in any material bond, debenture, note or any other evidence of indebtedness or any material indenture, mortgage, deed of trust
or any other agreement or instrument to which the Company is a party or by which it is bound or to which any of the property or
assets of the Company is subject. No consent, approval, authorization or other order of, or registration, qualification or filing
with, any regulatory body, administrative agency, governmental body or any other third-party is required for the execution and
delivery of the Transaction Documents by the Company, other than such as have been made or obtained, and except for any filings
required to be made under federal or state securities laws.


 


3.2Representations
and Warranties of the Purchasers. Each Purchaser, severally and not jointly, hereby
represents and warrants as follows:


 


(a)Such
Purchaser has received the Prospectus relating to the Securities and the Prospectus Supplement dated the date hereof. Such Purchaser
acknowledges that such Purchaser has received certain additional information regarding the Company’s offering of the Shares
and Warrants under the Registration Statement, including pricing information (the “Offering
Information”). Such Offering Information may be provided to the Purchaser by
any means permitted under the Securities Act, including through a prospectus supplement, a free writing prospectus or oral communications.
The foregoing, however, does not limit or modify the representations and warranties of the Company in Section 3.1 of this Agreement
or the right of such Purchaser to rely thereon.


 


(b)Such
Purchaser has full power and authority to enter into this Agreement and to consummate the transactions contemplated hereby and
has taken all necessary action to authorize the execution, delivery and performance of this Agreement, and this Agreement constitutes
a valid and binding obligation of such Purchaser enforceable against such Purchaser in accordance with its terms, except as limited
by applicable bankruptcy, insolvency, reorganization, moratorium, fraudulent conveyance, and any other laws of general application
affecting enforcement of creditors’ rights generally, and as limited by laws relating to the availability of specific performance,
injunctive relief, or other equitable remedies.


 


(c)Such
Purchaser understands that nothing in the Registration Statement, the Prospectus, the Prospectus Supplement, the Offering Information
and any amendments or supplements thereto, this Agreement or any other materials presented to such Purchaser in connection with
the purchase and sale of the Shares and Warrants constitutes legal, tax or investment advice. Such Purchaser has consulted such
legal, tax and investment advisors as it, in its sole discretion, has deemed necessary or appropriate in connection with its purchase
of the Shares and Warrants.


 


ARTICLE
IV.

OTHER AGREEMENTS OF THE PARTIES


 


4.1Warrant
Shares. If at any time following the date hereof the Registration Statement (or any
subsequent registration statement registering the exercise of the Warrant Shares) is not effective or is not otherwise available
for the sale or resale of the Warrant Shares, the Company shall immediately notify the holders of the Warrants in writing that
such registration statement is not then effective and thereafter shall promptly notify such holders when the registration statement
is again effective. The Company shall use best efforts to keep a registration statement (including the Registration Statement)
registering the issuance of the Warrant Shares effective during the term of the Warrants. 


 






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4.2Use
of Proceeds. The Company shall use the net proceeds from the sale of the Securities
hereunder for working capital purposes and as set forth in the Prospectus Supplement.


 


4.3Listing
of Common Stock. The Company hereby agrees to use best efforts to maintain the listing
or quotation of the Common Stock on the Trading Market on which it is currently listed, and concurrently with the Closing, the
Company shall apply to list or quote all of the Shares and Warrant Shares on such Trading Market and promptly secure the listing
of all of the Shares and Warrant Shares on such Trading Market. The Company further agrees, if the Company applies to have the
Common Stock traded on any other Trading Market, it will then include in such application all of the Shares and Warrant Shares,
and will take such other action as is necessary to cause all of the Shares and Warrant Shares to be listed or quoted on such other
Trading Market as promptly as possible. The Company will then use its reasonable best efforts to continue the listing and trading
of its Common Stock on a Trading Market and will comply in all respects with the Company’s reporting, filing and other obligations
under the bylaws or rules of the Trading Market.


 


4.4Subsequent
Transactions. Except with respect to an Exempt Issuance, from
the date hereof until 30 days after the Closing Date, neither the Company nor any Subsidiary shall issue, enter into any agreement
to issue or announce the issuance or proposed issuance of any shares of Common Stock or Common Stock Equivalents. “Exempt
Issuance” means the issuance of (a) shares of Common Stock or options to employees, officers or directors of the Company
pursuant to any stock or option plan duly adopted for such purpose, by a majority of the non-employee members of the Board of Directors
or a majority of the members of a committee of non-employee directors established for such purpose, (b) securities upon the exercise
or exchange of or conversion of any Securities issued hereunder and/or other securities exercisable or exchangeable for or convertible
into shares of Common Stock issued and outstanding on the date of this Agreement, provided that such securities have not been amended
since the date of this Agreement to increase the number of such securities or to decrease the exercise price, exchange price or
conversion price of such securities, and (c) securities issued pursuant to acquisitions or strategic transactions approved by a
majority of the disinterested directors of the Company, provided that any such issuance shall only be to a Person (or to the equityholders
of a Person) which is, itself or through its subsidiaries, an operating company or an owner of an asset in a business synergistic
with the business of the Company and shall provide to the Company additional benefits in addition to the investment of funds, but
shall not include a transaction in which the Company is issuing securities primarily for the purpose of raising capital or to an
entity whose primary business is investing in securities. 








ARTICLE V.


MISCELLANEOUS


 


 


5.1Fees
and Expenses. Each party shall pay the fees and expenses of its advisers, counsel,
accountants and other experts, if any, and all other expenses incurred by such party incident to the negotiation, preparation,
execution, delivery and performance of this Agreement. The Company shall pay all Transfer Agent fees, stamp taxes and other taxes
and duties levied in connection with the delivery of any Securities to the Purchasers.


 


5.2Entire
Agreement. The Transaction Documents, together with the exhibits and schedules thereto,
the Prospectus, the Prospectus Supplement and the Offering Information, contain the entire understanding of the parties with respect
to the subject matter hereof and supersede all prior negotiations, correspondence, agreements and understandings, oral or written,
with respect to such matters, which the parties acknowledge have been merged into such documents, exhibits and schedules.


 






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5.3Notices.
Any and all notices or other communications or deliveries required or permitted to be provided hereunder shall be in writing and
shall be deemed given and effective on the earliest of: (a) the date of transmission, if such notice or communication is delivered
via facsimile at the facsimile number set forth on the signature pages attached hereto prior to 5:30 p.m. (New York City time)
on a Trading Day, (b) the next Trading Day after the date of transmission, if such notice or communication is delivered via facsimile
at the facsimile number set forth on the signature pages attached hereto on a day that is not a Trading Day or later than 5:30
p.m. (New York City time) on any Trading Day, (c) the second (2nd) Trading Day following the date of mailing, if sent
by any U.S. nationally recognized overnight courier service or (d) upon actual receipt by the party to whom such notice is required
to be given if delivered personally. The address for such notices and communications shall be as set forth on the signature pages
attached hereto.


 


5.4Amendments;
Waivers. No provision of this Agreement may be waived, modified, supplemented or amended
except in a written instrument signed, in the case of an amendment, by the Company and the Purchasers holding at least 67% in interest
of the Shares then outstanding or, in the case of a waiver, by the party against whom enforcement of any such waived provision
is sought. Any amendment or waiver effected in accordance with this Section 5.4 shall be binding upon each Purchaser and the Company.
No waiver of any default with respect to any provision, condition or requirement of this Agreement shall be deemed to be a continuing
waiver in the future or a waiver of any subsequent default or a waiver of any other provision, condition or requirement hereof,
nor shall any delay or omission of any party to exercise any right hereunder in any manner impair the exercise of any such right.


 


5.5Headings.
The headings herein are for convenience only, do not constitute a part of this Agreement and shall not be deemed to limit or affect
any of the provisions hereof.


 


5.6Successors
and Assigns. This Agreement shall be binding upon and inure to the benefit of the
parties and their successors and permitted assigns. The Company may not assign this Agreement or any rights or obligations hereunder
without the prior written consent of each Purchaser (other than by merger). Any Purchaser may assign any or all of its rights under
this Agreement to any Person to whom such Purchaser assigns or transfers any Securities, provided that such transferee agrees in
writing to be bound, with respect to the transferred Securities, by the provisions of the Transaction Documents that apply to the
Purchasers.


 


5.7No
Third-Party Beneficiaries. This Agreement is intended for the benefit of the parties
hereto and their respective successors and permitted assigns and is not for the benefit of, nor may any provision hereof be enforced
by, any other Person.


 


5.8Governing
Law. All questions concerning the construction, validity, enforcement and interpretation
of the Transaction Documents shall be governed by and construed and enforced in accordance with the internal laws of the State
of New York, without regard to the principles of conflicts of law thereof. 


 


5.9Survival.
The representations, warranties and covenants contained herein shall survive the Closing and the delivery of the Securities.


 


5.10Execution.
This Agreement may be executed in two or more counterparts, all of which when taken together shall be considered one and the same
agreement and shall become effective when counterparts have been signed by each party and delivered to the other parties, it being
understood that all parties need not sign the same counterpart. In the event that any signature is delivered by facsimile transmission
or by e-mail delivery of a “.pdf” format data file, such signature shall create a valid and binding obligation of
the party executing (or on whose behalf such signature is executed) with the same force and effect as if such facsimile or “.pdf”
signature page were an original thereof. 


 



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5.11Severability.
If any term, provision, covenant or restriction of this Agreement is held by a court of competent jurisdiction to be invalid, illegal,
void or unenforceable, the remainder of the terms, provisions, covenants and restrictions set forth herein shall remain in full
force and effect and shall in no way be affected, impaired or invalidated, and the parties hereto shall use their commercially
reasonable efforts to find and employ an alternative means to achieve the same or substantially the same result as that contemplated
by such term, provision, covenant or restriction. It is hereby stipulated and declared to be the intention of the parties that
they would have executed the remaining terms, provisions, covenants and restrictions without including any of such that may be
hereafter declared invalid, illegal, void or unenforceable.


 


5.12Replacement
of Securities. If any certificate or instrument evidencing any Securities is mutilated,
lost, stolen or destroyed, the Company shall issue or cause to be issued in exchange and substitution for and upon cancellation
thereof (in the case of mutilation), or in lieu of and substitution therefor, a new certificate or instrument, but only upon receipt
of evidence reasonably satisfactory to the Company of such loss, theft or destruction. The applicant for a new certificate or instrument
under such circumstances shall also pay any reasonable third-party costs (including customary indemnity) associated with the issuance
of such replacement Securities.


 


5.13Independent
Nature of Purchasers’ Obligations and Rights. The obligations of each Purchaser
under any Transaction Document are several and not joint with the obligations of any other Purchaser, and no Purchaser shall be
responsible in any way for the performance or non-performance of the obligations of any other Purchaser under any Transaction Document.
Nothing contained herein or in any other Transaction Document, and no action taken by any Purchaser pursuant thereto, shall be
deemed to constitute the Purchasers as a partnership, an association, a joint venture or any other kind of entity, or create a
presumption that the Purchasers are in any way acting in concert or as a group with respect to such obligations or the transactions
contemplated by the Transaction Documents. Each Purchaser shall be entitled to independently protect and enforce its rights including,
without limitation, the rights arising out of this Agreement or out of the other Transaction Documents, and it shall not be necessary
for any other Purchaser to be joined as an additional party in any proceeding for such purpose. The Company has elected to provide
all Purchasers with the same terms and Transaction Documents for the convenience of the Company and not because it was required
or requested to do so by any of the Purchasers.


 


5.14Saturdays,
Sundays, Holidays, etc. If the last or appointed day for the taking of any action
or the expiration of any right required or granted herein shall not be a Business Day, then such action may be taken or such right
may be exercised on the next succeeding Business Day.


 


5.15Construction.
The parties agree that each of them and/or their respective counsel has reviewed and had an opportunity to revise the Transaction
Documents and, therefore, the normal rule of construction to the effect that any ambiguities are to be resolved against the drafting
party shall not be employed in the interpretation of the Transaction Documents or any amendments hereto. In addition, each and
every reference to share prices and shares of Common Stock in any Transaction Document shall be subject to adjustment for reverse
and forward stock splits, stock dividends, stock combinations and other similar transactions of the Common Stock that occur after
the date of this Agreement.


 


5.16WAIVER
OF JURY TRIAL. IN ANY ACTION, SUIT, OR PROCEEDING IN ANY JURISDICTION BROUGHT
BY ANY PARTY AGAINST ANY OTHER PARTY ARISING OUT OF OR RELATING TO THIS AGREEMENT AND THE OTHER TRANSACTION DOCUMENTS
OR THE TRANSACTIONS CONTEMPLATED HEREBY OR THEREBY, THE PARTIES EACH KNOWINGLY AND INTENTIONALLY, TO THE GREATEST EXTENT PERMITTED
BY APPLICABLE LAW, HEREBY ABSOLUTELY, UNCONDITIONALLY, IRREVOCABLY AND EXPRESSLY WAIVES FOREVER TRIAL BY JURY. 


 


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IN WITNESS WHEREOF,
the parties hereto have caused this Securities Purchase Agreement to be duly executed by their respective authorized signatories
as of the date first indicated above.


 


 


	
        ENTREMED, INC.

         

         
	 
	
        By:_____________________________

              Name: Cynthia W. Hu

              Title: COO, General Counsel & Secretary

         

        Address for notice:

         

        9620 Medical Center Drive

        Suite 300

        Rockville, Maryland 20850

        Attention: General Counsel & Secretary

        Facsimile: 240.864.2601

         

        With a copy to (which shall not constitute notice):
	 
	
         

        Richard E. Baltz

        Arnold & Porter LLP

        555 12th St., N.W.

        Washington, D.C. 20004

        Facsimile: 202.942.5999

         

         
	 


 


 


 


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SIGNATURE PAGE FOR PURCHASER FOLLOWS]




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[PURCHASER SIGNATURE PAGES TO SECURITIES
PURCHASE AGREEMENT]


 


IN WITNESS WHEREOF,
the undersigned have caused this Securities Purchase Agreement to be duly executed by their respective authorized signatories as
of the date first indicated above.


 


Name of Purchaser: _____________________________________________________________________


Signature of Authorized Signatory of Purchaser:
_______________________________________________


Name of Authorized Signatory: ____________________________________________________________


Title of Authorized Signatory: _____________________________________________________________


Facsimile Number of Authorized Signatory: ___________________________________________________


Address for Notice of Purchaser:


__________________________________________


__________________________________________


__________________________________________


__________________________________________


 


SUBSCRIPTION: $_____________ SHARES: __________ WARRANT SHARES:_____________


 


Address for Delivery of Warrants for Purchaser (if not same
as address for notice):


__________________________________________


__________________________________________


__________________________________________


__________________________________________


 


Shares to be delivered by (check one and complete the required
information in order to receive your shares):


 


 ̈ The Depository Trust
Company Deposit Withdrawal Agent Commission System (DWAC)


 





	 	_______________________________	 	__________________________	 
	 	Name of Brokerage Firm or Agent 	 	Account Name	 
	 	To Receive Shares	 	 	 
	 	 	 	 	 
	 	_______________________________	 	______________________	 
	 	Account No.	 	DTC No.	 







 


  


 ̈ Physical Stock Certificate


 


Address for Delivery of Stock Certificates for Purchaser
(if not same as address for notice):


 


__________________________________________


__________________________________________


__________________________________________


 






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EXHIBIT A

TO SECURITIES PURCHASE AGREEMENT


 


FORM OF WARRANT


 




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