# Patent

## Title
Method of alkylating or acylating an arene

## Abstract

A method of alkylating or acylating an arene includes reacting the arene with an organic halide in the presence of an aprotic solvent and a catalyst of formula (I)

MR1mXn.Z(R2)(R3)  (I)

wherein M is Al, Ga, or Fe; R1 is C1-C12 alkyl; m is 0 or 1; R2 and R3 are each independently unsubstituted or substituted C2-C12 alkyl; each occurrence of X is independently a halogen; n is 2 or 3; the sum of m and n is 3; and Z is S or O. When M is Al, then m is 1, n is 2, and R2 and R3 are each independently substituted with at least one electron-withdrawing group. When M is Ga or Fe, then m is 0 and n is 3.

## Background
CROSS REFERENCE TO RELATED APPLICATIONS
This application claims the benefit of U.S. Provisional Application No. 62/186,408, filed 30 Jun. 2015, which is incorporated by reference herein in its entirety.


BACKGROUND OF THE INVENTION
Alkylation of toluene or phenol is a typical Friedel-Crafts reaction that is important in industry due to the wide application of the alkylated products. Among the alkylated isomers, the para-counterpart such as para-alkylated toluene or phenol is highly desirable for industrial applications as essential feedstock for antioxidants, phenolic resins, ultraviolet absorbers, varnishes and heat stabilizers in polyolefins. P. Elavarasan, K. Kondamudi, S. Upadhyayula, Chem. Eng. 1 2011, 166, 340-347. 4-tert-butylphenol is used to make oils and phosphate esters. F. M. Moghaddam, M. Akhlaghi, L. Hojabri, M. G. Dekamin, Trans. C Chem. Chem. Eng. 2009, 16, 81-88. Thus, efficient and selective alkylation, to yield para-substituted alkyl aromatics has received tremendous interest in recent years. P. Lu, Z. Fei, L. Li, X. Feng, W. Ji, W. Ding, Y. Chen, W. Yang, Z. Xie, Appl. Catal., A 2013, 453, 302-309.
In the course of more than 100 years of Friedel-Crafts chemistry, considerable work has been done on aromatic alkylations utilizing Friedel-Crafts chemistry. G. A. Olah, Friedel-Crafts Chemistry; Wiley-Interscience: New York, 1973. Olah and coworkers reported Friedel-Crafts alkylation of anisole and toluene using metal halides such as AlCl3 and BF3. G. A. Olah, J. A. Olah, T. Ohyama, J. Am. Chem. Soc. 1984, 106, 5284-5290. The same group subsequently reported boron, aluminum, and gallium triflates as convenient and effective new Friedel-Crafts catalysts for alkylation of benzene and toluene. G. A. Olah, O. Farooq, S. M. F. Farnia, J. A. Olah, J. Am. Chem. Soc. 1988, 110, 2560-2565. However, the para-selectivity was poor due to rapid isomerization to a more thermodynamically favored meta isomer. Brown et al. obtained 10% meta substitution in methylation (C. R. Smoot, H. C. Brown, J. Am. Chem. Soc. 1956, 78, 6249-6254), 21% in ethylation (L. M. Stock, H. C. Brown, J. Am. Chem. Soc. 1960, 82, 1942-1947), 27% in isopropylation (H. C. Brown, H. Jungk, J. Am. Chem. Soc. 1955, 77, 5584-5589), 32% in tert-butylation (H. Jungk, C. R. Smoot, H. C. Brown, J. Am. Chem. Soc. 1956, 78, 2185-2190), and 21% in benzylation (H. C. Brown, C. R. Smoot, J. Am. Chem. Soc. 1956, 78, 6255-6259) in Friedel-Crafts alkylations of toluene. Gold and Riley reported the 60% perchloric acid catalyzed alkylation of anisole with alcohols and observed 45% ortho- and 55% para-alkylation with isopropyl alcohol and 20% ortho- and 80% para-alkylation with tent-butyl alcohol. V. Gold, T. Riley, J. Chem. Soc. 1962, 4183-4188. Kovacic and Hiller reported that alkylation of anisole with tert-butyl chloride (t-BuCl) gave 6% meta and 94% para isomer. P. Kovacic, J. J. Hiller, J. Org. Chem. 1965, 30, 1581-1588. Stang and Anderson studied the alkylation with vinyl triflates in the presence of a sterically hindered non-nucleophilic base 2,6-di-tert-butyl-4-methylpyridine producing 11% ortho and 89% para isomer for anisole alkylation and 28% ortho, 8% meta and 64% para isomer for toluene. P. J. Stang, A. G. Anderson, J. Am. Chem. Soc. 1978, 100, 1520-1525. Thus, it has been difficult to achieve high conversion retaining high para selectivity during alkylation of toluene and phenol. EtAlCl2 has been employed in cycloalkylation of benzene (R. Wolovsky, N. Maoz, Z. Nir, Synthesis 1970, 656-657) and alkylation of substituted arenes, but only in polar solvents such as dichloromethane (D. Chaturvedi, A. K. Chaturvedi, N. Mishra, V. Mishra, Org. Biomol. Chem. 2012, 10, 9148-9151).
There remains a need for Friedel-Crafts methods exhibiting high regioselectivity and conversion.
BRIEF SUMMARY OF EMBODIMENTS OF THE INVENTION
One embodiment is a method of alkylating or acylating an arene, the method comprising: reacting an arene with an organic halide selected from the group consisting of unsubstituted or substituted tertiary alkyl halides, unsubstituted or substituted allyl halides, unsubstituted or substituted benzyl halides, and unsubstituted or substituted acyl halides in the presence of a catalyst and an aprotic solvent; wherein the catalyst is of formula (I)

MR1mXn.Z(R2)(R3)  (I)

wherein M is Al, Ga, or Fe; R1 is C1-C12 alkyl; m is 0 or 1; R2 and R3 are each independently unsubstituted or substituted C2-C12 alkyl; each occurrence of X is independently a halogen; n is 2 or 3; the sum of m and n is 3; and Z is S or O; provided that when M is Al, then m is 1, n is 2, and R2 and R3 are each independently substituted with at least one electron-withdrawing group; and provided that when M is Ga or Fe, then m is 0 and n is 3.

This and other embodiments are described in detail below.



BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 shows representative proton nuclear magnetic resonance (1H NMR spectra for the reaction of toluene with tert-butyl chloride (t-BuCl) in presence of a complex of ethyl aluminum dichloride with bis(2-chloroethyl) ether (EADC·CEE) at different times at 0° C. in cyclohexane-d12. Initial conditions: [t-BuCl]=0.05 M, [EADC·CEE]=0.05 M, [CEE]/[EADC]=1. An asterisk (*) denotes the cyclohexane-d11H resonance.
FIG. 2 is a plot of conversion of t-BuCl to the alkylated product during Friedel-Craft alkylation reaction of toluene and/or phenol in presence of t-BuCl in cyclohexane-d12, calculated from the respective 1H NMR spectra at different time.
FIG. 3 shows a gas chromatography (GC) trace of the product of the t-butylation of toluene at 0° C. Initial conditions: [t-BuCl]=0.05 M, [EADC·CEE]=0.05 M, [CEE]/[EADC]=1, Temp: 0° C., EADC solution in toluene was used.
FIG. 4 is a gas chromatography-mass spectrometry (GC-MS) spectrum of the fraction at 5.90 min in the GC trace (FIG. 3) of the product of the t-butylation of toluene at 0° C. Initial conditions: [t-BuCl]=0.05 M, [EADC·CEE]=0.05 M, [CEE]/[EADC]=1, Temp: 0° C., EADC solution in toluene was used.
FIG. 5 is a GC-MS spectrum of the fraction at 5.99 min in the GC trace (FIG. 3) of the product of the t-butylation of toluene at 0° C. Initial conditions: [t-BuCl]=0.05 M, [EADC·CEE]=0.05 M, [CEE]/[EADC]=1, Temp: 0° C., EADC solution in toluene was used.
FIG. 6 is a comparison of para-selectivity of the product obtained via Friedel-Craft alkylation reaction of toluene and/or phenol in presence of t-BuCl in nonpolar solvent, determined from the GC-MS analysis.
FIG. 7 is a GC trace of the product of the t-butylation of phenol at 25° C. Initial conditions: [t-BuCl]=0.05 M, [EADC·CEE]=0.05 M, [Phenol]=0.05 M, [CEE]/[EADC]=1, Temp: 25° C., EADC solution in hexane was used.
FIG. 8 is a GC-MS spectrum of the fraction at elution time 9.53 min in the GC trace (FIG. 5) of the product of the t-butylation of phenol at 25° C. Initial conditions: [t-BuCl]=0.05 M, [EADC·CEE]=0.05 M, [Phenol]=0.05 M, [CEE]/[EADC]=1, Temp: 25° C., EADC solution in hexane was used.
FIG. 9 shows 1H NMR spectra of acetyl chloride (bottom), and [EADC·CEE+AcCl] in the presence of toluene after 8 minutes of acetylation at 0° C. in cyclohexane-d12 (top). Initial conditions: [AcCl]=0.05 M, [EADC·CEE]=0.05 M, [CEE]/[EADC]=1. An asterisk (*) denotes the cyclohexane-d11H resonance.
FIG. 10 shows iH NMR spectra of acetyl chloride (bottom), and [EADC·CEE+AcCl] in presence of phenol after 8 min of acetylation at 25° C. in cyclohexane-d12 (top). Initial conditions: [AcCl]=0.05 M, [EADC·CEE]=0.05 M, [Phenol]=0.05 M, [CEE]/[EADC]=1. An asterisk (*) denotes the cyclohexane-d11H resonance.
FIG. 11 is a GC trace of the product of the acetylation of toluene at 0° C. Initial conditions: [AcCl]=0.05 M, [EADC·CEE]=0.05 M, [CEE]/[EADC]=1, Temp: 0° C., EADC solution in toluene was used.
FIG. 12 is a GC-MS spectrum of the fraction at 8.8 min in the GC trace of the product of the acetylation of toluene at 0° C. Initial conditions: [AcCl]=0.05 M, [EADC·CEE]=0.05 M, [CEE]/[EADC]=1, Temp: 0° C., EADC solution in toluene was used.
FIG. 13 is a GC-MS spectrum of the fraction at 9.1 min in the GC trace of the product of the acetylation of toluene at 0° C. Initial conditions: [AcCl]=0.05 M, [EADC·CEE]=0.05 M, [CEE]/[EADC]=1, Temp: 0° C., EADC solution in toluene was used.
FIG. 14 is a GC trace of the product of the acetylation of phenol at 25° C. Initial conditions: [AcCl]=0.05 M, [EADC·CEE]=0.05 M, [Phenol]=0.05 M, [CEE]/[EADC]=1, Temp: 25° C., EADC solution in hexane was used.
FIG. 15 is a GC-MS spectrum of the fraction at elution time 10.3 min in the GC trace of the product of the acetylation of phenol at 25° C. Initial conditions: [AcCl]=0.05 M, [EADC·CEE]=0.05 M, [Phenol]=0.05 M, [CEE]/[EADC]=1, Temp: 25° C., EADC solution in hexane was used.



DETAILED DESCRIPTION OF THE INVENTION
Due to the limited solubility of the traditional catalysts, Friedel-Crafts reactions generally do not readily proceed in non-polar solvents. When hexane was used as solvent, only trace amounts of alkylated toluene products were observed using (pyrazol-1-ylmethyl)pyridine Ni complexes. S. O. Ojwach, I. A. Guzei, L. L. Benade, S. F. Mapolie, J. Darkwa, Organometallics 2009, 28, 2127-2133. Therefore, investigation of Friedel-Crafts reactions in non-polar solvents is of high importance. In the course of mechanistic studies on the polymerization of isobutylene (TB) using EtAlCl2/bis(2-chloroethyl) ether (EADC·CEE) complex in hexane, alkylation of toluene with t-BuCl as a side reaction was observed. Thus, we undertook an investigation of Friedel-Crafts alkylation and acylation of arenes in non-polar solvent using complexes of Lewis acids and Lewis bases.
One embodiment is a method of alkylating or acylating an arene, the method comprising: reacting an arene with an organic halide selected from the group consisting of unsubstituted or substituted tertiary alkyl halides, unsubstituted or substituted allyl halides, unsubstituted or substituted benzyl halides, and unsubstituted or substituted acyl halides in the presence of a catalyst and an aprotic solvent; wherein the catalyst is of formula (I)

MR1mXn.Z(R2)(R3)  (I)

wherein M is Al, Ga, or Fe; R1 is C1-C12 alkyl; m is 0 or 1; R2 and R3 are each independently unsubstituted or substituted C2-C12 alkyl; each occurrence of X is independently a halogen; n is 2 or 3; the sum of m and n is 3; and Z is S or O; provided that when M is Al, then m is 1, n is 2, and R2 and R3 are each independently substituted with at least one electron-withdrawing group; and provided that when M is Ga or Fe, then m is 0 and n is 3.

The arene that is alkylated or acylated can have one or more aromatic rings. When the arene has two or more aromatic rings, any two of the rings can be fused or not fused. In some embodiments, the arene is an unsubstituted or substituted C6-C18 arene. In the context of the arene, the term “substituted” means having one or more substituents selected from monovalent substituents including hydroxyl, C1-C12 alkyl (including linear and branched alkyl), C3-C12 cycloalkyl, C2-C12 alkenyl, C2-C12 alkynyl, C1-C12 alkoxyl, C1-C12 amido (including N-monoalkylamido and N,N-dialkylamido), C2-C12 ether, C2-C12 ester, cyano, cyanato, thiocyanato, isocyanato, isothiocyanato, and nitro; and divalent substituents including C1-C12 alkylene, C3-C12 cycloalkylene, C2-C12 alkenylene, C2-C12 alkynylene, carbonyl (—C(O)—), divalent ester (—C(O)—O—), and divalent C1-C12 amide (—C(O)—N(R)—, wherein R is H or C1-C11 alkyl).
In some embodiments, the arene is an unsubstituted or substituted benzene. In some embodiments, the arene is a monosubstituted benzene. As demonstrated in the working examples, the method provides selective alkylation of monosubstituted benzenes in the para position.
The arene is reacted with an organic halide that is an alkylating agent or an acylating agent. Examples of organic halides include unsubstituted or substituted tertiary alkyl halides, unsubstituted or substituted allyl halides, unsubstituted or substituted benzyl halides, and unsubstituted or substituted acyl halides. In the context of the organic halide, the term “substituted” means having one or more substituents selected from monovalent substituents including cyano, cyanato, thiocyanato, isocyanato, isothiocyanato, and nitro. In some embodiments, the organic halide is selected from the group consisting of C4-C12 tertiary alkyl chlorides, allyl chlorides, benzyl chlorides, and C2-C12 acyl chlorides. In some embodiments, the organic halide is t-butyl chloride or acetyl chloride.
The reaction of the arene with the organic halide occurs in the presence of an aprotic solvent. An aprotic solvent is a solvent that does not have a hydrogen atom bound to an oxygen atom or to a nitrogen atom. In some embodiments, the aprotic solvent is an aliphatic aprotic solvent. In some embodiments, the aprotic solvent is a C5-C12 alkane.
The reaction of the arene with the organic halide also occurs in the presence of a catalyst. The catalyst is of formula (I)

MR1mXn.Z(R2)(R3)  (I)

wherein M is Al, Ga, or Fe; R1 is C1-C12 alkyl; m is 0 or 1; R2 and R3 are each independently unsubstituted or substituted C2-C12 alkyl; each occurrence of X is independently a halogen; n is 2 or 3; the sum of m and n is 3; and Z is S or O; provided that when M is Al, then m is 1, n is 2, and R2 and R3 are each independently substituted with at least one electron-withdrawing group; and provided that when M is Ga or Fe, then m is 0 and n is 3. The formula (I) structure is a complex of a Lewis acid, MR1mXn, and a Lewis base, Z(R2)(R3). In some embodiments, M is Al, R1 is ethyl, and each occurrence of X is chloro; i.e., the Lewis acid is EtA1C12. In some embodiments, Z is O; i.e., the Lewis base is an ether. In some embodiments, M is Al, Z is O, and the at least one electron-withdrawing group is a halogen. In a subset of these embodiments, M is Al, Z is O, and the at least one electron-withdrawing group is chloro. In a preferred embodiment, M is Al, R1 is ethyl, each occurrence of X is chloro, Z is O, and R2 and R3 are —CH2CH2Cl.

Having chosen an arene, an organic halide, a solvent, and a catalyst, a person skilled in the art can determine other reaction conditions—such as temperature and reagent concentrations—without undue experimentation. For example, when the arene is a monoalkyl-substituted benzene, the organic halide is an unsubstituted tertiary alkyl halide, and the solvent comprises n-hexane, the reaction can be conducted at a temperature of −10 to +10° C.
The invention includes at least the following embodiments.
Embodiment 1
A method of alkylating or acylating an arene, the method comprising: reacting an arene with an organic halide selected from the group consisting of unsubstituted or substituted tertiary alkyl halides, unsubstituted or substituted allyl halides, unsubstituted or substituted benzyl halides, and unsubstituted or substituted acyl halides in the presence of a catalyst and an aprotic solvent; wherein the catalyst is of formula (I)

MR1mXn.Z(R2)(R3)  (I)

wherein M is Al, Ga, or Fe; R1 is C1-C12 alkyl; m is 0 or 1; R2 and R3 are each independently unsubstituted or substituted C2-C12 alkyl; each occurrence of X is independently a halogen; n is 2 or 3; the sum of m and n is 3; and Z is S or O; provided that when M is Al, then m is 1, n is 2, and R2 and R3 are each independently substituted with at least one electron-withdrawing group; and provided that when M is Ga or Fe, then m is 0 and n is 3.

Embodiment 2
The method of embodiment 1, wherein the arene is an unsubstituted or substituted C6-C18 arene.
Embodiment 3
The method of embodiment 1, wherein the arene is an unsubstituted or substituted benzene.
Embodiment 4
The method of embodiment 1, wherein the arene is a monosubstituted benzene.
Embodiment 5
The method of any one of embodiments 1-4, wherein the organic halide is selected from the group consisting of C4-C12 tertiary alkyl chlorides, allyl chloride, benzyl chloride, and C2-C12 acyl chlorides.
Embodiment 6
The method of any one of embodiments 1-4, wherein the organic halide is t-butyl chloride or acetyl chloride.
Embodiment 7
The method of any one of embodiments 1-6, wherein the aprotic solvent is an aliphatic aprotic solvent.
Embodiment 8
The method of any one of embodiments 1-6, wherein the aprotic solvent is a C5-C12 alkane.
Embodiment 9
The method of any one of embodiments 1-8, wherein M is Al, R1 is ethyl, and each occurrence of X is chloro.
Embodiment 10
The method of any one of embodiments 1-9, wherein Z is O.
Embodiment 11
The method of any one of embodiments 1-9, wherein M is Al, Z is O, and the at least one electron-withdrawing group is a halogen.
Embodiment 12
The method of any one of embodiments 1-9, wherein M is Al, Z is O, and the at least one electron-withdrawing group is chloro.
Embodiment 13
The method of any one of embodiments 1-8, wherein M is Al, R1 is ethyl, each occurrence of X is chloro, Z is O, and R2 and R3 are —CH2CH2Cl.
Embodiment 14
The method of embodiment 13, wherein the arene is a monoalkyl-substituted benzene, wherein the organic halide is an unsubstituted tertiary alkyl halide, wherein the solvent comprises n-hexane, and wherein said reacting is conducted at a temperature of −10 to +10° C.
All ranges disclosed herein are inclusive of the endpoints, and the endpoints are independently combinable with each other. Each range disclosed herein constitutes a disclosure of any point or sub-range lying within the disclosed range.
The use of the terms “a” and “an” and “the” and similar referents in the context of describing the invention (especially in the context of the following claims) are to be construed to cover both the singular and the plural, unless otherwise indicated herein or clearly contradicted by context. Further, it should further be noted that the terms “first,” “second,” and the like herein do not denote any order, quantity, or importance, but rather are used to distinguish one element from another. The modifier “about” used in connection with a quantity is inclusive of the stated value and has the meaning dictated by the context (e.g., it includes the degree of error associated with measurement of the particular quantity).
The invention is further illustrated by the following non-limiting examples.
WORKING EXAMPLES
Materials. Tert-butyl chloride (t-BuCl, 98%, TCI America) and acetyl chloride (AcCl, >99%, Fluka) were used as received. Ethylaluminum dichloride (EADC, 25.7 weight percent solution in toluene), EADC (1.0 M solution in hexane), bis(2-chloroethyl) ether (CEE, 99%), potassium hydroxide (KOH, 90%), sodium hydroxide (NaOH, ≧98%), sodium sulfate (Na2SO4), 2-propanol (IPA, ≧99.5%), sodium acetate (NaOAc, 99%), ethylenediaminetetraacetic acid (EDTA, ≧98.5%) and dithizone (85%) were purchased from Aldrich and used without any further purification. Ammonium acetate (NH4OAC) and zinc sulfate heptahydrate (ZnSO47H2O) were purchased from Fisher Scientific and used as received. 4-tert-Butyltoluene (>95.0%), 4-tert-butylphenol (>98.0%), 4′-methylacetophenone (>95.0%), 4′-hydroxyacetophenone (>98.0%) were purchased from TCI America and used as received.
Hexanes, mixture of isomers (Hex, Sigma-Aldrich, ≧98.5%, ACS reagent), was freed from olefinic impurities by refluxing over concentrated sulfuric acid for 48 hours. It was then washed with aqueous solution of KOH (10 weight percent) three times followed by washing with distilled water until neutral to pH paper. Then it was kept over anhydrous Na2SO4 overnight at room temperature and finally distilled over CaH2 under a nitrogen atmosphere twice before use in the Friedel-Crafts reaction
Preparation of EADC·CEE Complex. Complexes of EADC and CEE ([CEE]/[EADC]=1) were prepared just before use in the reaction. For this, first, the concentration of Al in the EADC in toluene and EADC in hexane (purchased from Aldrich) was determined. Then inside a glove box, an equimolar amount of CEE was added to the EADC solution and vortexed to form a 1.8 M Lewis acid/ether complex while using EADC solution in toluene, and a 0.996 M Lewis acid/ether complex while using EADC solution in hexane. The required amount of the complex was then added to 1.0 mL cyclohexane-d12 to make the final concentration of the Lewis acid/ether complex at 0.05 M.
Determination of Al Content of EADC. Typically, 1 mL EADC solution was taken up in a 20 mL sealed vial inside the glove box. The vial was taken out of the glove box and EADC was dissolved in de-ionized water by adding dilute HC1 and by refluxing. The solution was allowed to cool to room temperature. 15 mL of the standardized 0.05 M of EDTA solution was added into the beaker containing the decomposed EADC solution. The solution was diluted with 50 mL of de-ionized water. The pH was adjusted to 5 with dilute NaOH. 10 mL of sodium acetate buffer was added to the solution, refluxed for 3 minutes and allowed to cool to room temperature. Then 10 mL of ammonium acetate, 75 mL of 2-propanol and 1 mL of dithizone indicator solution were added. The solution was titrated against a standard 0.02 M ZnSO4 solution to a pink end point to give the concentration of Al.
General Method for Alkylation using EADC·CEE complex. In a typical experiment, alkylation of phenol was carried out in cyclohexane-d12 at 25° C. using the following initial concentrations of reactants: [Phenol]=0.05 M, [EADC·CEE]=0.05 M and [t-BuCl]=0.05 M. 50 μL of 1.0 M EADC·CEE complex was added to a solution containing 5 μL phenol and 1.0 mL cyclohexane-d12 at 25° C. in a MBraun MB200MOD stainless steel glove box (Innovative Technology Inc.) equipped with a gas purification system (molecular sieves and copper catalyst) under dry nitrogen atmosphere. It was vortexed to mix the components and kept at 25° C. t-BuCl (5 μl) was added to it to start the reaction at 25° C. The progress of the reaction was monitored by taking 1H NMR spectrum of the reaction mixture at different times at 25° C. It was thereafter quenched with chilled methanol. Isomer distribution was determined by GC-MS analysis. Alkylation of toluene was carried out as described in case of phenol.
General Method for Acylation using EADC·CEE complex. In a typical experiment, acylation of phenol was carried out in cyclohexane-d12 at 25° C. using the following initial concentrations of reactants: [Phenol]=0.05 M, [EADC·CEE]=0.05 M and [AcCl]=0.05 M. 50 μL of 1.0 M EADC·CEE complex was added to a solution containing 5 μL phenol and 1.0 mL cyclohexane-d12 at 25° C. in a MBraun MB200MOD stainless steel glove box (Innovative Technology Inc.) equipped with a gas purification system (molecular sieves and copper catalyst) under dry nitrogen atmosphere. It was vortexed to mix the components and kept at 25° C. AcCl (4 μL) was added to it to start the reaction at 25° C. AcCl (4 μL) was added to it to start the reaction. The progress of the reaction was monitored by taking 1H NMR spectrum of the reaction mixture at different times at 25° C. It was thereafter quenched with chilled methanol. Isomer distribution was determined by GC-MS analysis. Acetylation of toluene was carried out using similar procedure.
Characterization. Nuclear Magnetic Resonance (NMR) Spectroscopy. Proton nuclear magnetic resonance CH NMR) spectra were recorded on a Bruker 500 MHz spectrometer using cyclohexane-d12 as solvent (Cambridge Isotope Laboratory, Inc.).
Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR). ATR-FTIR spectra were taken using a Mettler Toledo React IR 4000 instrument equipped with a DiComp probe connected to an MCT detector with a K6 conduit in the spectral range from 4000 to 650 cm−1 at a resolution of 2 cm−1.
Gas Chromatography-Mass Spectrometry Analysis. The gas chromatography-mass spectrometry (GC-MS) analysis of all the products was performed using an Agilent 7890A (GC)-Agilent 5975 C inert MSD with triple axis detector and an Agilent 7693 autosampler from Agilent Technologies. The temperatures of the transfer line, the quadrupole and the ion source were set at 320, 150 and 230° C., respectively. The system was operated by Agilent MSD ChemStation E.02.00.493 software. Separation was carried out on a nonpolar DB-5 capillary column (Agilent) with length=30 meter, ID=0.250 mm, film thickness=0.25 um for toluene alkylation samples and a polar crossbond PEG column (RESTEK USA cat #12423, serial #503025) with length=30 meter, ID=0.250 mm, film thickness=0.25 μm for phenol alkylation samples. Helium (purity 99.999%) was employed as carrier gas at a constant column flow of 1.0 mL min−1. The GC oven temperature was programmed from 60° C. (held for 2 min) to 140° C. at 10° C. min−1 (held for 1 min) for toluene alkylation samples, and programmed from 60° C. (held for 3 min) to 220° C. at 10° C. min−1 (held for 1 min) for phenol alkylation samples. The injector temperature was kept at 260° C. The injection volume was 2 μL. For acetylation products, separation was carried out on a polar crossbond PEG column (RESTEK USA cat #12423, serial #503025) with length=30 meter, ID=0.250 mm, film thickness=0.25 μm for phenol alkylation samples. The GC oven temperature was programmed from 60° C. (held for 0 min) to 180° C. at 10° C. min−1 (held for 0 min) for toluene acetylation samples and from 60° C. (held for 3 min) to 220° C. at 10° C. min−1 (held for 1 min) for phenol acetylation samples.
The alkylation of toluene with t-BuCl was studied using EADC·CEE complex at 0 and 25° C., and using just EADC at 0° C. in cyclohexane-d12. The progress of the reaction was monitored by 1H NMR spectroscopy. FIG. 1 depicts typical 1H NMR spectra during alkylation of toluene at 0° C. at different times. FIG. 1 shows a decrease of the intensity of the methyl resonance at 1.6 ppm (corresponding to t-BuCl) and increase of the methyl resonance at 1.3 ppm (corresponding to tert-butyltoluene) with time. Quantitative conversions were observed in 2 hours (Table 1). The conversion of t-BuCl to the alkylated toluene is plotted as a function of time in FIG. 2 based on the integrations of the corresponding proton signals. According to FIG. 2, alkylation of toluene is much faster at 25° C. compared to that at 0° C. Furthermore, alkylation of toluene using just EADC at 0° C. is much faster than that using EADC·CEE complex at 0° C.







TABLE 1







Screening of reaction parameters for Friedel-Crafts alkylation/acylation reaction in


nonpolar solvent.a


















Temp.
Time
Conversion
Product Composition (%)
















#
Substrate
Reagent
Catalyst
(° C.)
(min)
(%)
ortho
meta
para



















1
Tolueneb
t-BuCl
EADC•CEE
0
120
96
0
5
95


2
Tolueneb
t-BuCl
EADC•CEE
25
120
100
0
30
70


3
Tolueneb
t-BuCl
EADC
0
120
100
0
32
68


4
Phenolc
t-BuCl
EADC•CEE
25
150
100
0
0
100


5
Tolueneb
AcCl
EADC•CEE
0
8
100
0
3
97


6
Phenolc
AcCl
EADC•CEE
25
8
100
0
0
100





aReaction condition: [t-BuCl] or [AcCl] = 0.05M, [EADC•CEE] or [EADC] = 0.05M, [Phenol] = 0.05M, [CEE]/[EADC] = 1, solvent = cyclohexane-d12,


bEADC in toluene solution used;


cEADC in hexane solution used. Entries 1-4: Alkylation with t-BuCl; Entries 5-6: Acetylation with AcCl.






The products of the alkylation of toluene were identified using GC-MS analysis and the results are summarized in Table 1 in terms of the aromatic product distribution after 2 hours of reaction. A GC trace of the representative alkylated products of toluene (FIG. 3) revealed the presence of two regioisomers. Based on the fragmentation pattern and the molecular ion peak of the GC-MS spectrum of the two peaks, the identity of the two isomers were confirmed as 4-tert-butyltoluene (95%) and 3-tert-butyltoluene (5%) (FIGS. 4, 5). The molar fraction of 4-tert-butyltoluene is herein defined as the para-selectivity. However, when the temperature of the alkylation reaction was raised to 25° C. from 0° C. and also when EADC is used alone as the catalyst instead of EADC·CEE complex the para selectivity decreases from 95% to  ̃70% (Table 1, entries 1-3). The presence of only 5% of meta isomer in the alkylation product of toluene alkylation obtained using EADC·CEE complex at 0° C. suggests a limited degree of isomerization compared to that using just EADC at 0° C. or using EADC·CEE complex at 25° C. where  ̃30% meta isomer was produced. Thus, our preliminary experiments indicated that use of EADC·CEE complex is necessary to obtain high para selectivity (FIG. 6).
Alkylation of phenol using EADC·CEE complex in non-polar solvent yielded even better para selectivity. FIG. 7 shows the GC trace of the product of alkylation of phenol using EADC·CEE complex at 25° C. These conditions yielded only a single isomer with near quantitative yield after 2.5 hours. From the fragmentation pattern and the molecular ion peak 135 of the GC-MS spectrum (FIG. 8), the species at 9.55 min (FIG. 7) was confirmed to be 4-tert-butylphenol. Thus, GC-MS result confirms the exclusive para selective alkylation of phenol in presence of t-BuCl using EADC·CEE complex at 25° C. (Table 1, entry 4).
Also studied was acetylation of toluene and phenol with acetyl chloride (AcCl) as a model Friedel-Crafts acylation reactions (Table 1, entries 5-6). The acetylation reactions were very fast; quantitative conversions were achieved in 8 min (FIGS. 9, 10). GC-MS analysis of the products of acetylation reveal that acetylation of toluene produces predominant para substitution (para isomer, 97%; meta isomer, 3%), whereas acetylation of phenol produces exclusively para isomer (FIGS. 11-15).
In summary, the experiments above demonstrate a simple and efficient catalyst for Friedel-Crafts alkylation/acylation reaction in non-polar solvent. The products were obtained in good yields and with high para selectivity. Furthermore, the catalyst was selective to only mono-alkylated products.

## Claims

1. A method of alkylating or acylating an arene, the method comprising:
reacting an arene with an organic halide selected from the group consisting of unsubstituted or substituted tertiary alkyl halides, unsubstituted or substituted allyl halides, unsubstituted or substituted benzyl halides, and unsubstituted or substituted acyl halides in the presence of a catalyst and an aprotic solvent; wherein the catalyst is of formula (I)


MR1mXn.Z(R2)(R3)  (I)


wherein
M is Al, Ga, or Fe;
R1 is C1-C12 alkyl;
m is 0 or 1;
R2 and R3 are each independently unsubstituted or substituted C2-C12 alkyl;
each occurrence of X is independently a halogen;
n is 2 or 3;
the sum of m and n is 3; and
Z is S or O;
provided that when M is Al, then m is 1, n is 2, and R2 and R3 are each independently substituted with at least one electron-withdrawing group; and
provided that when M is Ga or Fe, then m is 0 and n is 3.

2. The method of claim 1, wherein the arene is an unsubstituted or substituted C6-C18 arene.

3. The method of claim 1, wherein the arene is an unsubstituted or substituted benzene.

4. The method of claim 1, wherein the arene is a monosubstituted benzene.

5. The method of claim 1, wherein the organic halide is selected from the group consisting of C4-C12 tertiary alkyl chlorides, allyl chloride, benzyl chloride, and C2-C12 acyl chlorides.

6. The method of claim 1, wherein the organic halide is t-butyl chloride or acetyl chloride.

7. The method of claim 1, wherein the aprotic solvent is an aliphatic aprotic solvent.

8. The method of claim 1, wherein the aprotic solvent is a C5-C12 alkane.

9. The method of claim 1, wherein M is Al, R1 is ethyl, and each occurrence of X is chloro.

10. The method of claim 1, wherein Z is O.

11. The method of claim 1, wherein M is Al, Z is O, and the at least one electron-withdrawing group is a halogen.

12. The method of claim 1, wherein M is Al, Z is O, and the at least one electron-withdrawing group is chloro.

13. The method of claim 1, wherein M is Al, R1 is ethyl, each occurrence of X is chloro, Z is O, and R2 and R3 are —CH2CH2Cl.

14. The method of claim 13, wherein the arene is a monoalkyl-substituted benzene, wherein the organic halide is an unsubstituted tertiary alkyl halide, wherein the solvent comprises n-hexane, and wherein said reacting is conducted at a temperature of −10 to +10° C.