EXHIBIT 10.3

SECOND AMENDMENT TO EMPLOYMENT AGREEMENT

This Second Amendment (the
Amendment), effective as of December 10, 2010 (the Effective Date), to the employment agreement, dated as of September 18, 2007, as amended by the amendment to the employment agreement dated October 27, 2008
(the Employment Agreement) is entered into by and between Curis, Inc., a Delaware corporation (the Company), and Daniel R. Passeri (the Executive).

WHEREAS, the Company and the Executive desire to amend the Employment Agreement to reflect changes which the parties hereby agree
to in connection with the Companys continued employment of the Executive.

NOW, THEREFORE, in
consideration of the mutual covenants and agreements set forth herein and for good and valuable consideration, the receipt and adequacy of which are hereby acknowledged, the parties hereto agree as follows:



|1. | Amendment. Section 5(e)(iv) of the Employment Agreement is hereby amended by deleting such Section in its entirety and substituting therefor the following:
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5(e)(iv). The receipt of any severance benefits provided for under the Employment Agreement as amended by
this Amendment or otherwise shall be dependent upon the Executives delivery to the Company of an effective general release of claims in a form satisfactory to the Company. Such release must be delivered and become irrevocable within sixty
(60) days of the date of the Executives termination of employment. Payment of the benefits shall be made or commence no later than the thirtieth (30th) day following the date on which the release becomes irrevocable. Notwithstanding
the foregoing, if the 90th day following the termination of employment occurs in the calendar year following the year of the Executives termination of employment then the severance payments shall not be made or commence prior to January 1
of the year following such termination of employment, and in any event, payment of benefits under this subparagraph shall be subject to the provisions of Subsection 5(e)(iii) to the extent applicable.



|2. | Reference to and Effect on the Employment Agreement; Entire Agreement. Except as amended or superseded by this Amendment, the provisions of the Employment
Agreement shall remain in full force and effect. This Amendment, together with the Employment Agreement, sets forth the entire agreement of the parties hereto in respect of the subject matter contained herein and supercedes all prior agreements,
whether oral or written, by any officer, employee or representative of any party hereto in respect of the subject matter contained herein; and any prior agreement of the parties hereto in respect of the subject matter contained herein is hereby
terminated and cancelled.
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|3. | Counterparts. This Amendment may be executed in two counterparts, each of which shall be deemed to be an original, but all of which together shall constitute one
and the same instrument.
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IN WITNESS WHEREOF, the undersigned have executed this Amendment as of the date
written above.



CURIS, INC.By:

/s/ Michael P. GrayName:

Michael P. GrayTitle:

Chief Operating Officer and
Chief Financial OfficerEXECUTIVE/s/ Daniel R. PasseriName:

Daniel R. Passeri


[Signature Page
to Second Amendment to Employment Agreement]