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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549





FORM 10-K





(Mark One)

|x | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ------------------------------------------------------------------------------------

For the fiscal year ended December 31, 2010



| ̈ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------

For the transition period from              to

Commission file number: 000-30267





ORCHID CELLMARK INC.

(Exact name of registrant as specified in its charter)







|                                                               |  |                                     
|-------------------------------------------------------------- |  | ------------------------------------
|Delaware                                                       |  | 22-3392819                          
|(State or other jurisdiction of incorporation or organization) |  | (I.R.S. Employer Identification No.)
|                                                               | 
|4390 US Route One, Princeton, NJ                               |  | 08540                               
|(Address of principal executive offices)                       |  | (Zip code)                          

Registrants telephone number, including area code: (609) 750-2200





Securities registered pursuant to Section 12(b) of the Exchange Act:





|                                        |  |                                          
|--------------------------------------- |  | -----------------------------------------
|Title of each class                     |  | Name of each exchange on which registered
|Common Stock, $.001 Par Value Per Share |  | The NASDAQ Stock Market LLC              
|Preferred Share Purchase Rights         |  | The NASDAQ Stock Market LLC              

Securities registered pursuant to Section 12(g) of the Exchange Act:

None

(Title of Class)





Indicate by
check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.    Yes   ̈    No  x

Indicate by check mark if the registrant is not required to file reports pursuant
to Section 13 or Section 15(d) of the Exchange Act.    Yes   ̈    No  x

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the
Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90
days.    Yes  x    No   ̈

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive
Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such
files).    Yes   ̈    No   ̈

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and will
not be contained, to the best of registrants knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment to this Form 10-K.    x

Indicate by check mark whether the registrant is a large accelerated filer, an
accelerated filer, a non-accelerated filer, or a smaller reporting company. See definitions of large accelerated filer, accelerated filer and smaller reporting company in Rule 12b-2 of the Exchange Act. (Check
one):



|                                                                       |  |                             
|---------------------------------------------------------------------- |  | ----------------------------
|Large accelerated filer   ̈                                             |  | Accelerated filer   ̈        
|Non-accelerated filer   ̈ (do not check if a smaller
reporting company) |  | Smaller reporting company  x

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange
Act)    Yes   ̈    No  x

The aggregate market value of the registrants common stock held by non-affiliates of the registrant (without admitting that any
person whose shares are not included in such calculation is an affiliate) computed by reference to the price at which the common stock was last sold as of the last business day of the registrants most recently completed second fiscal quarter
was approximately $37,451,577.

As of March 11, 2011, the registrant had 29,992,186 shares of common stock outstanding.

DOCUMENTS INCORPORATED BY REFERENCE

Certain information required in Part III of this Annual Report on Form 10-K is incorporated by reference from the registrants Proxy Statement for the Annual Meeting of Stockholders to be held on
May 25, 2011.









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ORCHID CELLMARK INC.

FORM 10-K

INDEX



|           |  |                                                                                                              |    |      |    | 
|---------- |  | ------------------------------------------------------------------------------------------------------------ | -- | ---- | -- | 
|           |  |                                                                                                              |    | Page |   
|           |  | PART I                                                                                                       |    |      |    | 
|ITEM 1.    |  | BUSINESS                                                                                                     |    |      | 1  | 
|ITEM 1A.   |  | RISK FACTORS                                                                                                 |    |      | 8  | 
|ITEM 1B.   |  | UNRESOLVED STAFF COMMENTS                                                                                    |    |      | 19 | 
|ITEM 2.    |  | PROPERTIES                                                                                                   |    |      | 19 | 
|ITEM 3.    |  | LEGAL PROCEEDINGS                                                                                            |    |      | 20 | 
|ITEM 4.    |  | [REMOVED AND RESERVED]                                                                                       |    |      | 21 | 
|           |  |                                                                                                             
|           |  | PART II                                                                                                      |    |      |    | 
|ITEM 5.    |  | MARKET FOR REGISTRANTS COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUER PURCHASES OF EQUITY SECURITIES |    |      | 22 | 
|ITEM 6.    |  | SELECTED FINANCIAL DATA                                                                                      |    |      | 23 | 
|ITEM 7.    |  | MANAGEMENTS DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS                        |    |      | 24 | 
|ITEM 7A.   |  | QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK                                                   |    |      | 38 | 
|ITEM 8.    |  | FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA                                                                  |    |      | 39 | 
|ITEM 9.    |  | CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURE                         |    |      | 64 | 
|ITEM 9A.   |  | CONTROLS AND PROCEDURES                                                                                      |    |      | 64 | 
|ITEM 9B.   |  | OTHER INFORMATION                                                                                            |    |      | 65 | 
|           |  |                                                                                                             
|           |  | PART III                                                                                                     |    |      |    | 
|ITEM 10.   |  | DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE                                                       |    |      | 65 | 
|ITEM 11.   |  | EXECUTIVE COMPENSATION                                                                                       |    |      | 65 | 
|ITEM 12.   |  | SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERS               |    |      | 65 | 
|ITEM 13.   |  | CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE                                    |    |      | 65 | 
|ITEM 14.   |  | PRINCIPAL ACCOUNTANT FEES AND SERVICES                                                                       |    |      | 66 | 
|           |  |                                                                                                             
|           |  | PART IV                                                                                                      |    |      |    | 
|ITEM 15.   |  | EXHIBITS AND FINANCIAL STATEMENT SCHEDULES                                                                   |    |      | 67 | 
|SIGNATURES |  |                                                                                                              | 71 |     





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PART I

Item 1. BUSINESS

The following Business
section contains forward-looking statements, which involve risks and uncertainties. Actual results could differ materially from those anticipated in these forward-looking statements as a result of certain factors. See Item 1A. Risk Factors
below for a discussion of these factors.

Orchid Cellmark Inc. including all its subsidiaries and affiliates are
collectively referred to herein as the Company, us or we.

We are engaged in the provision
of DNA testing services that generate genetic profile information by analyzing an organisms unique genetic identity. We also provide non-DNA forensic laboratory services.

The process of identifying unique variations in a genome is referred to as DNA testing. An individuals identity can be confirmed
with almost absolute certainty through DNA testing. First used to establish human identity in 1985, DNA testing is the standard method used for forensic identification and to confirm paternity and other family relationships. DNA testing is also used
in agricultural applications for selective trait breeding and related applications. DNA testing is sometimes also referred to in the industry as DNA fingerprinting, DNA typing, DNA profiling or genotyping.

Our business is primarily focused on DNA testing for human identity. We provide DNA testing services for forensic, family relationship
and, to a lesser extent, security applications. Forensic DNA testing is primarily used in the following ways: to establish and maintain DNA profile databases of individuals arrested for or convicted of crimes; to analyze and compare evidence from
crime scenes with these databases to identify possible suspects; and to confirm that a suspect committed a particular crime or to exonerate a falsely accused or convicted person. Forensic DNA testing can also be used to confirm a victims
identity. Family relationship DNA testing is used to establish whether two or more people are genetically related. It is most often used to determine a biological father in a paternity case, but can also be used to confirm a genetic relationship for
purposes of immigration, adoption, estate settlement, genealogy and ancestry. DNA testing also is used by individuals and employers in security applications to establish and store a persons genetic profile for identification purposes in the
event of an emergency or accident.

We also provide DNA testing services for agricultural applications, primarily in selective
trait breeding. We provide agricultural susceptibility testing to enable farmers to breed sheep resistant to scrapie, a fatal, degenerative disease that affects the nervous systems of sheep and goats. We also provide genetic marker analysis in
animals that can be used to confirm relationships.

We have operations in the United States, or the US, and in the United
Kingdom, or the UK, and the majority of our current customers are based in these two countries. We provide our DNA testing services to various government agencies, private individuals and commercial companies. During the years ended
December 31, 2010, 2009, and 2008, we recorded total revenues of $63.7 million, $59.1 million and $57.6 million, respectively, of which $23.7 million, $29.6 million and $31.2 million, respectively, were from our US operations. We recorded
international revenues, primarily in the UK, of $40.0 million, $29.5 million and $26.4 million for the years ended December 31, 2010, 2009 and 2008, respectively. One customer accounted for approximately 25% of our total revenues in 2010. No
single customer accounted for more than 10% of our revenues in 2009 or 2008.

Our principal executive offices are located at
4390 US Route One, Princeton, New Jersey, 08540. Our telephone number is (609) 750-2200 and our website address is www.orchidcellmark.com. Our Corporate Code of Business Conduct and Ethics as well as our Annual Reports on Form 10-K,
Quarterly Reports on Form 10-Q and Current Reports on Form 8-K and all amendments to these reports, which have been filed with the Securities and Exchange Commission, or SEC, are available free of charge through the Investor Relations section on our
website as soon as reasonably practicable after such materials have been electronically filed with, or furnished to,



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the SEC. The public may also read and copy any materials we file with the SEC at the SECs Public Reference Room, 100 F Street, NE, Washington, D.C. 20549. The public may also obtain
information on the operation of the Public Reference Room by calling the SEC at 1-800-SEC-0330. Because we file reports and other information with the SEC electronically, the public may obtain access to those documents at the SECs internet
website: www.sec.gov. We include our website address in this Annual Report on Form 10-K as an inactive textual reference only.

Background

All living
organisms contain DNA, which encodes genetic information in cells. DNA determines the structure, function and behavior of cells and individual hereditary characteristics. DNA was first used to confirm human identity in 1985 and has since been used
to revolutionize many applications involving individual identification, particularly in connection with forensic investigations. The introduction of DNA testing into the criminal justice system, both in the US and abroad, has been characterized as
the most significant improvement in forensic science since the introduction of fingerprinting over 100 years ago. DNA evidence left behind at a crime scene affords prosecutors a means of identifying a suspect with almost absolute certainty. In
addition, DNA evidence has proved to be the best currently available method for a wrongfully accused individual to prove his or her innocence.

After the first phase of the human genome sequence was completed in 2000, attention turned from mapping the sequence of the genome to identifying genetic differences between individuals and applying this
knowledge to the healthcare and other related fields. Scientists have analyzed large portions of DNA to determine the sequence of nucleotide bases within the human genome and within the genomes of plant and animal species. Scientists hope to
understand and use this molecular level knowledge to transform traditional approaches to medicine, agriculture and other fields. The increasing availability of non-human genomic data is driving the use of genetic variability information for animal
identification, which is expected to produce improved characteristics in livestock or crops and protect humans against animal-borne diseases.

Technologies Utilized

All DNA testing currently used for identity purposes examines specific segments of DNA that exhibit variability between different
individuals and animals. Two forms of such variability are known as short tandem repeats, or STRs, which we utilize in DNA testing services for forensic, family relationship and security applications, and single nucleotide polymorphisms, or SNPs,
which we utilize in DNA testing services for agricultural applications and in some of our forensic DNA testing services.

STRs

An STR is a portion of DNA in which small segments are repeated a variable number of times. Typically, there are 10 to 25
possible variations of a given human STR marker, with each person having just one or two variations. By looking at a moderate number of STRs, a DNA profile is determined that is virtually unique for each individual. STRs are the most common genetic
markers used in the industry to determine identity in forensic, paternity and security applications.

A DNA profile can be
determined from any type of biological specimen containing nuclear DNA, including blood or a tissue sample, such as a cheek swab. These specimens may be used for determining profiles of suspects, victims and criminals and for paternity testing. The
STR markers used to establish a persons identity are selected specifically to be able to confirm identity without inadvertently providing other information about the individual, such as information concerning the individuals current
health or susceptibility to certain diseases or adverse responses to medications.

A DNA profile can also be determined from
DNA contained in biological evidence from a crime scene, such as blood stains, semen, hair, skin, bone, teeth and even minute traces of saliva resident on items such as cigarette butts and postage stamps. DNA profiles derived from crime scene
evidence can be compared with that



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of a suspect or victim, and can be catalogued in a database for future comparison, much like fingerprints. DNA testing can also be used to confirm that a suspect committed a particular crime or
exonerate a falsely accused or convicted person. In various countries around the world, DNA samples are collected from suspected or convicted criminals, profiled and entered into national databases. Evidence from crime scenes in which no suspect has
yet been identified can be analyzed and compared with this database to possibly identify a suspect. In the US, there are 13 standard STR markers that are analyzed by public and private forensic laboratories to establish DNA profiles. These profiles
can then be uploaded to the FBI-managed national criminal database known as the Combined DNA Index System, or CODIS, as well as to individual state databases. In the UK, 10 standard STR markers are used to compile the UK National DNA Database, or
NDNAD.

DNA testing may also be used in paternity and other family relationship testing. Since DNA markers are inherited, the
profile of a child can be compared with that of the alleged father to confirm or exclude him as the childs biological father. Similarly, DNA markers can prove family relationships for several other purposes including individuals immigrating to
a country or for children being adopted. Individuals and employers also use DNA testing to establish and store a persons genetic identity for future reference in the event of an emergency or accident.

SNPs

The second form of
variability in DNA involves a change in a SNP, which is the most common form of genetic variation. We use SNPs to determine commercially desirable qualities, such as disease resistance, in animals. Analyzing SNPs in animals can provide animal
breeders with genetic data relating to such characteristics as meat quality and milk production. We also use SNPs for some of our forensic DNA testing services.

Testing Services

In the human identity area, we provide DNA testing
services for forensic, family relationship and, to a lesser extent, security applications. In agricultural applications, we provide DNA testing services for selective trait breeding.

Based on our review of publicly available information regarding contract sizes and competitor activity, supplemented by industry
publications and third-party market assessment data, we believe we are one of the largest providers of forensic and family relationship testing both in the US and the UK. Based on these same sources, we believe that the US and UK are some of the
largest existing markets for DNA testing services today, and the majority of our current customers are based in these countries. We conduct forensic DNA testing primarily for government agencies. We perform family relationship testing services for
both government agencies and private individuals. We market security DNA testing services to government agencies, commercial companies and private individuals. We perform agricultural DNA testing services for government agencies and members of the
agricultural community. We have two accredited laboratories in the US and two in the UK, which provide all of our DNA testing services. In 2010, we consolidated our four US testing facilities into two laboratories.

In the US and UK, a significant amount of our current testing activity is under established contracts with a number of different
government agencies. These contracts are usually awarded through a sealed bid process and, when awarded, typically have a term from one to three years. We believe that our experience as a reliable provider of services to government agencies is a
valued credential that can be used in securing both new contracts and renewing existing contracts.

We intend to continue to
evaluate and commercialize new technologies for enhancing our laboratory processes, including instrumentation, automation and new testing methodologies, which we expect will enable us to reduce our costs and improve the quality of our service
offerings. All of the reagents and instruments utilized in our services are highly specialized. We currently purchase the majority of reagents and other components for



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use in our DNA testing services from a single supplier. While comparable reagent kits and instruments are available from multiple suppliers in the event of a supply problem, switching suppliers
would require obtaining the approval of certain of our customers and may necessitate changing instruments on which we perform DNA testing services, which could require significant capital investment.

Human Identity DNA Testing Services

Forensic DNA Testing Services

We are a leading forensic DNA testing
provider and are known for the high quality of our services and the expertise of our staff. We test a variety of forensic evidence samples collected at crime scenes, also known as casework. Testing services can implicate or exclude a known suspect,
or may, in the absence of a suspect, generate a DNA profile of a perpetrator for use in searching criminal DNA databases. Although the majority of forensic testing services are done for criminal justice agencies, we also provide testing services for
defense attorneys. Casework testing is provided on an individual case basis or under contract. Government contract services are usually awarded through a competitive bid process in which specifications are issued in the form of a request for
proposal, or RFP, or in the form of an invitation to bid, or ITB, and vendors respond with a sealed bid by a specified date. These contracts typically have a term of one to three years.

In addition to casework testing, we also provide DNA identification profiles of individuals for inclusion in national, state and local
criminal DNA databases. In the US, DNA specimens are collected from convicted criminals and certain arrestees and are tested by our laboratory to provide DNA profiles for inclusion in the CODIS database, as well as individual state databases. In the
UK, under the UK Police and Criminal Evidence Act, or PACE, DNA specimens are also collected from certain arrestees and are tested by us to provide DNA profiles for inclusion in the NDNAD. DNA evidence from criminal cases with no known suspects may
be screened against these databases to help identify a possible suspect.

In the US, as of January 2011, the CODIS database
stored the DNA profiles of over 9.2 million convicted offenders and over 356,000 forensic case DNA profiles. To date, more than 130,000 criminal investigations have been aided in the US by matching DNA profiles generated from crime scene
evidence against the CODIS database. In the UK, the NDNAD currently stores more than 5.8 million DNA profiles, and through the use of this database, more than 410,000 suspects to crime scene matches have been made since the databases
inception in 1995. We anticipate volume growth in CODIS and a relatively stable market for NDNAD work based on legislation in both the US and the UK. In the US, there have been a number of contracts awarded by states to address the backlog of cases
with no known suspect for screening against the CODIS database. At this time, 49 states have passed legislation requiring DNA profiling of felons and 24 states have passed legislation requiring DNA profiling of arrestees. DNA testing is starting to
be used in the US for non-violent crimes like burglary and auto theft, while the UK already has had considerable success using DNA evidence to solve these types of property crimes.

Our forensic testing services are performed in our accredited facilities located in Dallas, Texas, Abingdon, UK and Chorley, UK. In
January 2010, we announced a planned consolidation of our Nashville, Tennessee forensic DNA testing facility into our Dallas, Texas facility, which we completed in the quarter ended September 30, 2010. Our operating costs have been
favorably impacted by the consolidation of our testing facilities.

Our forensic testing facility in the US is accredited by
the American Society of Crime Lab Directors/Laboratory Accreditation Board, or ASCLD/LAB, and the National Forensic Science Testing Center, or NFSTC. All of our forensic testing facilities also maintain ISO 17025 Forensic Quality Services, or FQS-I,
accreditation and our UK forensic testing laboratory also maintains ISO 9001:2000 accreditation.

The value of DNA testing in
solving crimes is increasingly being recognized and we anticipate that federal and state governments in the US will allocate greater resources to support wider use of DNA testing. This was evidenced by the US legislation known as The Justice
for All Act of 2004, encompassed in the US DNA



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Testing Initiative, in which the federal government allocated more than $1 billion over fiscal years 2005 to 2009 towards reducing the backlog of forensic testing that currently exists in the US
criminal justice system. New federal and state legislation currently is being considered to reduce the national rape kit backlog and clear thousands of existing rape kits in police and government crime lab storage facilities. Although no statistical
database exists for the exact number of untested rape kits held in evidence backlog in the US, some estimates of the backlog put the number between 180,000 and 400,000 kits. Additional federal legislation in the US was passed that allows for a
significant expansion of forensic DNA testing of arrestees and includes provisions for DNA testing of illegal immigrants. Through a process directed by the National Institute of Justice, or NIJ, states may apply for federal funds to assist in
testing the enormous backlog of untested cases with no known suspect. Portions of the funds awarded to the states are designated for outsourcing to private sector laboratories. Contracts are awarded through the NIJ or by the states receiving the
federal funds under competitive procurement. Such contracts are awarded based on a matrix of criteria including price, experience, capacity and quality, and are usually for a term of one to three years with options to extend under certain
circumstances. Virtually all contracts require ASCLD/LAB, ISO 17025 FQS-I or NFSTC accreditation.

We provide a full range of
forensic DNA testing services to UK police forces, from the routine analysis of DNA samples for submission to the NDNAD to the analysis of evidence for the most serious crimes. This testing is provided through our UK facilities. UK government
funding for DNA analysis increased significantly in past years through its DNA Expansion Plan and we believe that the UK government and police forces will continue to support the use of DNA testing in forensic cases. In 2008, the UK established the
National Procurement Plan, a formalized bidding process under which police forces collectively tender their forensic work for bid.

Prior to 2009, a significant portion of our UK forensics revenues were derived through a subcontracting agreement with a provider of analytical and diagnostic services. In 2007, UK police forces commenced
soliciting competitive bids for all forensic testing services in a series of regional tenders. In February 2008, we were awarded, overall, a significant portion of the service packages we bid on in the North West/South West and Wales regional
tender. We were awarded work from nine of the fourteen police forces that participated in this tender. Under the terms of this award, we are providing forensic services, including DNA testing of database crime scene samples, forensic casework and
database testing services under PACE for multiple police forces that collectively tendered their work. In August 2010, such contracts were extended for a two-year term ending in 2013. In October 2010, we commenced work for five UK police forces in
the East Midlands region under three-year contracts awarded under the National Forensic Procurement Project. Under the terms of this award, we are conducting DNA analysis of crime scene samples for submission to the NDNAD. We believe that the
actions we have taken to date have enabled us to successfully transition from our prior reliance on revenues derived from acting as a subcontractor to directly providing these services to government agencies and police forces in the UK.

In December 2010, the UK government determined to wind down operations at the Forensic Science Service, or FSS, one of our competitors
for forensic work in the UK. FSS, formerly part of the U.K. Home Office and once the sole provider of services to UK Police forces, became a GovCo, a non-public company solely owned by the government, in 2005. FSS currently holds the largest share
of the U.K. forensic testing market. This development is significant to our UK forensics business and we are focused on providing services to a larger segment of UK police forces.

Each of our forensic DNA testing facilities has broad capabilities in handling the complex evidence samples related to casework. Further,
we have developed, and continue to develop, processes and procedures designed to allow us to handle larger testing volumes to the extent required under specific contracts, or in response to the expanding government initiatives to reduce the backlog
of no-suspect cases. We have continued to expand our service offerings in forensic testing with new technology or novel approaches for special cases, new services to help solve non-violent crimes and our DNA Express Service, which provides
accelerated testing services at a premium price in the US market. Specialty testing services include Y chromosome STR analysis, which is important in sexual assault analysis, as well as mitochondrial DNA testing and SNP based testing, both of which
are beneficial in analyzing very small or extremely degraded DNA samples. We believe that DNA testing of



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non-violent or property crime evidence is a growth area for our forensics business. Recent studies in the US have shown that the DNA testing of property crime evidence is twice as effective as
fingerprinting when both types of evidence are available and DNA testing of property crimes can reduce annual property crime rates.

Family Relationship DNA Testing Services

Family relationship DNA
testing is used to establish that two or more people are genetically related, and is most often used to determine a biological father of a particular child in a paternity case. It can also be used to confirm a genetic relationship for purposes of
immigration, adoption, estate settlement, genealogy, ancestry and storing genetic profiles. We offer paternity DNA testing services to both governmental agencies and private customers. Laboratory testing is done in our accredited laboratories
located in Dayton, Ohio and Abingdon, UK. In October 2009, we announced a consolidation of our East Lansing, Michigan paternity testing operations into our Dayton, Ohio facility which we completed during the quarter ended March 31, 2010.
Our operating costs have been favorably impacted by the consolidation of our testing facilities.

Government paternity
testing

The government paternity testing market in the US and UK, which comprises the majority of our paternity testing
services, involves tests ordered by state or county governmental agencies commonly referred to as Child Support Enforcement Agencies, or CSEAs. In the US, CSEAs are required by law to identify the biological father of a child if the child is born
out of wedlock, or in the case of divorce, if a presumptive father files a successful motion to have biological paternity questioned. In the US, effective October 1, 2006, the federal government decreased its reimbursement percentage of the
costs of paternity testing incurred by CSEAs from 90% to 66%, which has caused us to experience severe pricing pressure in our government funded paternity services. The federal government reimburses the CSEAs, provided they abide by certain federal
regulations. These regulations, which have aided the expansion of the market, provide incentives to the CSEAs to increase effectiveness and efficiency in their paternity establishment measures. We provide services to our government paternity clients
under contracts which typically have a term of one to three years and are awarded in a competitive bidding process. The contract bidding process is highly competitive and the criteria used to determine the awards vary. Typically, specifications are
issued in the form of a RFP or ITB and vendors respond with a sealed bid by a specified date. In some cases, contracts are awarded solely on the basis of price, while in other cases, a scoring matrix to achieve the desired mix of price, quality and
service is used. In the UK, there is only one child support agency, administered by the Department for Work and Pensions, which is responsible for helping to identify the biological father of a child. We were selected in a competitive bidding
process as the exclusive provider of paternity testing services to this agency in 2009 and this contract has been extended through December 2013.

Private paternity testing

Private paternity testing is relationship DNA
testing marketed and provided to private individuals. Our private paternity DNA testing services are provided in the US and UK to members of the public and legal and healthcare professionals. In addition to offering services directly to individuals,
we have relationships with firms and individuals acting as our marketing agents in the US. We typically supply products and materials to these marketing agents and, in return, the agent agrees to exclusively utilize our services for their customers
seeking private paternity testing.

Immigration and Other DNA Testing Setvices

We also provide testing services to private individuals wishing to immigrate to the US, Canada or the UK, as well as to certain foreign
government immigration agencies. This testing is done to verify claimed family relationships for visa applications. We provide this testing under contract or from an approved vendor list.

Our other DNA testing services include testing which is designed to help identify workers on high-risk assignments in the event of an
emergency or accident, to confirm Native American genetic lineage for tribal enrollment and DNA profiling to allow individuals to preserve their genetic history.



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Through our facility in the UK, we conduct genotyping services under the UK
governments project to help British farmers breed sheep with reduced susceptibility to the animal disease scrapie. The project has been part of the National Scrapie Plan, or NSP, for the UK developed by the Department for Environment, Food and
Rural Affairs, or DEFRA, in conjunction with the Agriculture and Rural Affairs Departments in Scotland and Wales. Our current agreement with DEFRA expires in September 2011. DEFRA will continue to have a requirement for scrapie genotyping for
monitoring purposes but we anticipate that it will be at a much reduced volume and it is uncertain that we will be awarded a new contract for such testing. Therefore we expect our future agricultural testing services revenues will not be significant
to our operating results.

Intellectual Property

We currently own, or have exclusive licenses to a number of US issued patents and foreign issued patents. Of our existing patent portfolio, approximately one-half primarily relates to microfluidic
technology. The microfluidic technology patents do not relate to our current business of DNA testing services. The remainder of our patent portfolio includes methods to identify and utilize SNPs. We have sought and intend to continue to seek patent
protection for certain uses of SNPs in the genetic testing field. In cases where novel uses of SNPs have already been patented by a third party, we may need to obtain a license for the use of this technology to make use of or sell services or
products using such technology. As of December 31, 2010, the majority of patents that we own or exclusively license have approximately four years remaining before they expire.

Our patent strategy is to protect existing intellectual property relevant to our focused business of DNA testing services. We rely on
both patent and trade secret protection of our intellectual property. However, we cannot be certain that patents will be issued from any of our patent applications or that any issued patents will have sufficient breadth to offer meaningful
protection. In addition, issued patents owned by us or patents licensed to us may be successfully challenged, invalidated, circumvented or determined to be unenforceable so that our patent rights would not create an effective competitive barrier.
The laws of some foreign countries may not protect our proprietary rights to the same extent as US laws. Our existing patent portfolio continues to reflect our international scope and includes pursuing patent protection mainly in North America and
Europe.

We continue to maintain a number of out-license agreements that rely on technology we own claimed under US patent
numbers 5,888,819, 6,013,431 and 6,004,744. We also provide agricultural testing services that rely on the technology claimed in the aforementioned patents, as well as technology we exclusively license claimed under patent number 5,846,710. We
license these patents under exclusive agreements with Saint Louis University.

We further attempt to protect our trade secrets
by entering into confidentiality agreements with third parties, employees and consultants. Our employees and certain of our consultants also sign agreements requiring that they assign to us their interests in discoveries, inventions, patents and
copyrights arising from their work for us, maintain the confidentiality of our intellectual property and refrain from unfair competition with us during their employment and, in some cases, for a period of time after their employment with us, which
includes solicitation of our employees and customers. We cannot assure you that these agreements will not be breached or invalidated. In addition, we cannot assure you that third parties will not independently discover or invent competing
technologies or reverse engineer our trade secrets or other technologies.

This Annual Report on Form 10-K contains references
to some of our trademarked products and services, for which we have filed registration applications with the US Patent and Trademark Office. All other trademarks or trade names referred to in this Annual Report on Form 10-K are the property of their
respective owners.

Government Regulation

In the US, the paternity and forensic testing industries are not regulated by any governmental agency. Rather, each industry establishes and maintains standards and quality through voluntary third-party
accreditation. The most widely recognized body covering paternity testing is the American Association of Blood Banks, or



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AABB. For forensic testing, the principal US entities that afford accreditation are ASCLD/LAB and NFSTC. All of our US facilities are accredited by the appropriate agency relative to the type of
testing performed at that facility. Many of our contracts require us to maintain some or all of these accreditations.

In the
UK, the NDNAD requires us, as a provider of forensic testing in the UK, to comply with the ISO 17025 standards described above.

In the US and UK, we are also subject to numerous environmental and safety laws and regulations, including those governing the use and
disposal of hazardous materials. The cost of any possible violation of these regulations could have an adverse effect on our business and results of operations.

Employees

As of December 31, 2010, we had 530 employees. None of our
employees are represented by a collective bargaining agreement, nor have we experienced any work stoppages. We believe that we maintain good relationships with our employees. Our success will depend in part on our ability to attract and retain
skilled and experienced employees, including our ability to recruit an adequate number of trained DNA analysts.

Competition

In each of our markets, we compete with other companies offering services that are similar to those that we offer. In
addition, in the US, government laboratories also provide forensic DNA testing services for their jurisdictions, which is a significant share of the testing done in the US. Some of our competitors have greater financial, operational, sales and
marketing resources and more experience in research and development and commercialization than we have. Other competitors have been acquired during the last 18 months and may have additional resources through such acquisitions. Moreover, some
competitors may have greater name recognition than we do, and may offer discounts on their services or products as a competitive tactic.

In the field of forensic DNA testing, our competitors include the following entities: The Bode Technology Group, Sorenson Genomics and Laboratory Corporation of America in the US, along with FSS, LGC Ltd.
and Key Forensics in the UK. Our competitors in the field of family relationship testing include the following entities: Laboratory Corporation of America, DNA Diagnostics, Sorenson Genomics and Paternity Testing Corporation in the US, along with
Crucial Genetics, Anglia DNA, LGC, Forensic Science Service, DadCheck, DNA Bioscience, The Paternity Company, DNA Now and DNA Diagnostics in the UK.

Item 1A. RISK FACTORS

If any of the
matters included in the following risks were to occur, our business, financial condition, results of operations, cash flows or prospects could be materially adversely affected. In such case, the value of our common stock could decline and you could
lose all or part of your investment.

Risks Related to Our Business

If we fail to maintain the service contracts we have with various governmental agencies or fail to enter into additional contracts, we would lose a
significant source of revenues.

We currently derive almost all of our revenues from forensic and family relationship
testing. These services are heavily dependent upon contracts with various governmental agencies, which are typically open to bids and usually have a term from one to three years. The process and criteria for these awards are typically complex and
highly competitive, particularly with respect to the price of the services offered. Bid awards also are subject to protests which can be expensive to prosecute or defend and which may delay the awarding of a contract. Although we have not previously
been debarred or disqualified for breach or non-performance of any contract, if



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such debarment or disqualification were to occur, we may not be awarded future government contracts. For example, we expect the police forces in the UK to continue to solicit tenders for forensic
services through the UKs National Procurement Plan. If we are unable to successfully bid on a significant portion of this work, our UK revenues and results of operations could be adversely affected. We may not be able to maintain any of our
existing governmental contracts or be the successful bidder on any additional governmental contracts which may become available in the future, or we may not be able to negotiate terms acceptable to us in connection with any governmental contract
awarded to us, which could adversely affect our results of operations and financial condition.

The markets in which we participate are
very competitive and price sensitive, and if we do not compete effectively, our operating results may be harmed.

The
markets for DNA testing services in the US and the UK are very competitive and we expect competition to intensify in the future. Pricing pressures and increased competition generally could result in reduced sales, reduced margins or our failure to
increase market share. In each of our markets, we compete with other companies offering services that are similar to those that we offer. In both the US and the UK, we have experienced lower average selling prices per sample as a result of
significant price competition. In addition, in the US, government laboratories also provide forensic DNA testing services for their jurisdictions, which is a significant portion of all forensic DNA testing done in the US. Some of our competitors
have greater financial, operational, sales and marketing resources and more experience in research and development and commercialization than us. Other competitors have been acquired during the last 18 months and may have additional resources
through such acquisitions. Moreover, some competitors may have greater name recognition than us, and may offer discounts on their services or products as a competitive tactic.

Many of our customers, or the contracts on which we bid, are price sensitive, and a critical aspect of our business is determining the appropriate prices for our services. As the market for our services
matures, or as new competitors compete with our services, we may be unable to renew our agreements with existing customers, attract new customers at the same price or based on the same pricing model as previously used, or win competitive bids with
governmental agencies. As a result, it is possible that competitive dynamics in our market may require us to change our pricing model or reduce our prices, which could harm our revenue, gross margin and operating results. In addition, our ability to
obtain awards under the UKs National Procurement Plan will directly impact our UK revenues over the next few years, and if our bidding under this plan is unsuccessful, our business, results of operation and financial condition could be
adversely impacted.

Our reliance on a small number of customers for a large portion of our revenue could harm our business and
prospects if work from those customers is delayed or terminated.

During fiscal 2010, our business was dependent on
sales to a small number of customers. One customer accounted for approximately 25% of our total revenues. We cannot provide any assurance that this customer will increase or maintain its level of demand for the Companys services or seek price
concessions. A significant number of the Companys contracts may be terminated at the customers discretion. The termination of our relationship with a significant customer or the reduction in business by such customer would substantially
reduce our revenues, and our business may be harmed.

If government funding is not available to reduce the rape kit backlog or if this
work is not outsourced to private laboratories, our business may be adversely affected.

A significant portion of our
North American forensic revenue in 2010 was derived from contracts with various law enforcement and governmental agencies for the provision of DNA testing services related to rape kits held in evidence backlog. If government funding is not made
available to reduce the rape kit backlog or if such rape kits are not outsourced to private laboratories such as us, our results of operations and financial condition may be adversely affected.



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We cannot guarantee the receipt of work or revenues from our government contracts.

We regularly compete in an open bid forum in order to secure or renew contracts with various law enforcement and governmental agencies for
the provision of DNA-based testing services. A contract award may be subject to funding obligations by the applicable government and there can be no assurances that such funding will be renewed. Many contracts with governmental agencies allow for
the agency to terminate a contract at any time if funding is not available to pay for our services. There also may be operational factors that disrupt the flow of work to us. Thus, we are not always able to rely on a fixed amount of revenue based on
services provided under these contracts. These administrative and operational issues are beyond our control and may delay the receipt of work under an award, which may have an adverse effect on our results of operations and financial condition
during a given fiscal period.

We cannot guarantee that we will be awarded a significant portion of the service packages under the
UKs National Procurement Plan.

We expect the police forces in the UK to continue to solicit tenders for
forensics services through the UKs National Procurement Plan, a formalized bidding process implemented in 2008. Although we were awarded a significant portion of the service packages we bid on in the North West/South West and Wales regional
tender and were awarded contracts under the East Midlands tender, we cannot guarantee that we will win a significant portion of the service packages under the National Procurement Plan. If we are unsuccessful in securing a sufficient number of
service packages under the National Procurement Plan, our results of operations and financial condition would be materially adversely affected.

If we fail to provide adequate service levels to police forces under the UK National Procurement Plan, we may be required to issue service credits
which would reduce the amounts payable for our services and adversely affect our business.

Under the National
Procurement Plan in the U.K., we are contractually obligated to meet certain service levels, such as turnaround time, when delivering forensic services to participating police forces. If we fail to meet these service levels, the applicable police
force is entitled to a service credit which reduces the amount payable to us by 2% to 10% depending on the degree of the service failure. In such event, the amounts payable for our services could be significantly reduced and our results of
operations and financial condition could be adversely affected.

Work awarded to us in the UK may be subject to unanticipated TUPE
expenses.

DNA testing work awarded to us in the UK may be subject to the hiring or compensatory obligations under the
UKs Transfer of Undertakings (Protection of Employment), or TUPE, regulations. TUPE is the UK employment legislation that governs the transfer of employment obligations from one party to another. If we are unable to properly anticipate the
amount of TUPE-related expenses, we may not realize the benefits of a DNA testing contract awarded to us. If we are obligated to pay a significant amount of TUPE-related expenses in connection with any award or in connection with the winding down of
the FSS, our results of operations financial condition could be adversely affected.

International sales are subject to increased costs
and other risks, which could affect our revenues.

Our business includes international sales which are subject to
certain inherent risks, including difficulties in collecting accounts receivable, potentially longer payment cycles, increased costs associated with maintaining international marketing efforts, currency fluctuations as they impact reported results,
changes in regulatory requirements and difficulties in enforcement of contractual obligations and intellectual property rights. During 2010, we derived approximately 63% of our revenues from international sales. The significant percentage of our
revenue derived from our UK operations makes us vulnerable to future fluctuations in the exchange rate. For the year ended December 31, 2010, as compared to 2009, our UK revenues were unfavorably impacted



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approximately 2% as a result of the exchange rate movement of the British pound as compared to the US dollar, and future material adverse exchange rate movements would have an additional
unfavorable translation impact on our consolidated financial results.

If general economic trends continue to decline, trends in
government spending and, therefore, demand for DNA testing services may change and reduce demand for our services, which would have a materially negative impact on our business.

A majority of our revenue is derived from contracts with various law enforcement and governmental agencies for the provision of DNA-based
testing services. Many national, state and local government entities are currently experiencing severe financial distress due to global economic conditions. Current economic conditions may adversely affect the ability of our government customers to
fund their operating budgets. Federal, state and local government spending both in the US and the UK for programs involving services such as ours may be reduced or delayed, now or in the future, due to reducd tax revenues or other spending
priorities. During the years ended December 31, 2009 and 2010, some government customers sought price reductions from all vendors and suppliers, including DNA testing providers like us because of budgetary concerns. As a result our government
customers may reduce budgets, which could have a negative effect on our revenue, gross margin and operating results. Any adverse impact of economic conditions on us is difficult to predict, but it may result in reductions in demand for our DNA
testing services. If events negatively impact the economy, our results of operations may be adversely affected.

Changes in outsourcing
trends for forensic DNA testing could adversely affect our operating results and growth rate.

Our forensic revenues
depend greatly on the expenditures made by government entities for DNA testing for forensic casework and CODIS. Accordingly, economic factors and industry trends that affect our government customers also affect our business. For example, the
practice of many state governments in the US has been to engage outside organizations like us to conduct forensic DNA testing. This practice has grown significantly in the last decade, and we have benefited from this trend. However, if this trend
was to change and states were to reduce the amount of forensic DNA testing they outsource, our results of operations and financial condition could be materially adversely affected.

Recent turmoil across various sectors of the financial markets may negatively impact our business.

In recent years, various sectors of the credit markets and the financial services industry have been experiencing a period of unprecedented turmoil and upheaval characterized by the disruption in credit
markets and availability of credit and other financing, the failure, bankruptcy, collapse or sale of various financial institutions and an unprecedented level of intervention from the US and foreign governments. While the ultimate outcome of these
events cannot be predicted, they may have a material adverse effect on our ability to obtain financing necessary to effectively execute our long-term strategies, and this could have a material adverse effect on the market price of our common stock
and our business, results of operations and financial condition.

The change in the method of awarding CODIS contracts has adversely
affected our CODIS business.

Prior to 2008, the NIJ administered all federally-funded CODIS awards to the
participating states, including the selection of the DNA testing vendor. Starting in 2008, however, the states were given the option to apply for grants from the NIJ and administer the awards directly. Each state would then select the vendor, or
vendors, to process their DNA samples, rather than the NIJ making that selection. The number of states issuing CODIS bids decreased significantly since 2008. We believe that backlogs of DNA samples at the state level are increasing and that states
will eventually move to administer the awards to private laboratories in order to bring down backlogs. We also believe that excess CODIS capacity has been built-up in the private sector and this may affect pricing in the future. If states do not
seek competitive bids for this CODIS work in a timely manner or if we are



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unsuccessful in securing a sufficient number of CODIS awards at acceptable prices in the future, our results of operations and financial condition would be materially adversely affected.

We recently completed building a new CODIS laboratory at our Dallas, Texas facility, and if we fail to properly manage the testing
capacity of this new laboratory, our business may suffer.

As part of the consolidation of our US forensic testing
laboratories, we established a new CODIS laboratory in our Dallas, Texas facility. We leased additional space at our Dallas location and made certain capital expenditures to build this new laboratory. If we fail to properly manage the
testing capacity of this new CODIS laboratory, our results of operations and financial condition might be adversely affected. In order to manage the testing capacity of this new CODIS laboratory, we must successfully manage additional
laboratory personnel for this new facility and increase the number of samples processed in this new facility. If we fail to properly manage the testing capacity of this new laboratory, our business might be adversely affected.

If we fail to comply with industry regulations and accreditations, we may not be able to provide certain services at our laboratories.

All of our laboratory facilities must comply with various industry regulations and accreditation standards in order to
continue to provide our paternity testing, forensic casework testing and CODIS testing. For example, our paternity laboratories have obtained accreditation from the AABB in order to provide paternity testing, and our forensic laboratory in the U.S.
is accredited by from ASCLD/LAB and NFSTC. In addition, our UK laboratory must maintain ISO 17025 accreditation in order to continue to provide forensic testing services. We cannot assure you that we will be able to maintain our accreditations with
any of these authorities as requirements and standards may change from time to time. The loss of our accreditations could adversely affect our existing contracts which, in many cases, require that we maintain these accreditations, and could
adversely affect our ability to enter into new contracts. As a result the loss of any such accreditation, our revenues could be eliminated or significantly reduced.

Our testing activities also involve the controlled use of hazardous materials. We are subject to laws and regulations governing the use, storage, handling and disposal of such materials and certain waste
products, as well as the conveyance, processing and storage of biological specimens. If we were in violation of any laws or regulations pertaining to the handling or use of hazardous materials, the remediation costs could be significant and could
have an adverse effect on our results of operations and financial condition.

We currently rely primarily on a single supplier for the
majority of reagents and other components we need for the performance of our DNA testing services.

We utilize one
supplier through which we purchase the majority of reagents and other components for use in our DNA testing services. In the event that we are unable to obtain supplies from this supplier, we do have the ability to purchase reagents and components
from other suppliers. However, if we had to switch to a different supplier or multiple suppliers, we would be required to obtain the approval of certain of our customers and we also may be required to change the instruments on which we perform DNA
testing services, which could require significant capital investment. In addition, we receive and expect to continue to receive substantial discounts based upon reaching a specific threshold of purchases per year of reagents and other components
from our current supplier. If we fail to reach the required threshold of purchases in any one year, our future discounts on purchases of reagents and other components from our current supplier would decrease, which could have an adverse effect on
our results of operations and financial condition.

Our future sales and marketing efforts may not be successful in achieving revenue
growth.

We plan to continue to market our services to governmental agencies, commercial companies and private
individuals. Our ability to successfully obtain new business, and where appropriate, enter into and maintain agreements with our customers, depends in part on the quality and pricing of our services. If we are unable to



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successfully implement our marketing plans, fail to maintain or enhance the quality of our services, or fail to offer attractive pricing for our services, our results of operations and financial
condition could be adversely affected.

We have limited sales and marketing resources, and as a result, we may not achieve our
expected levels of revenue.

We currently have limited sales and marketing resources and we are subject to
the possibility that our competitors may recruit our employees. As of December 31, 2010, only one of our key sales and marketing employees had an employment contract with us. We also do not maintain key man life insurance
policies for any of our key sales and marketing employees. Our sales and marketing resources are used to market our services to governmental agencies, commercial companies and private individuals. If our limited sales and marketing resources become
inadequate, our results of operations and financial condition could be adversely affected.

Future acquisitions or mergers could disrupt
our ongoing operations, increase our expenses and adversely affect our revenues.

We anticipate that a portion of our
future growth may be accomplished either by acquiring or merging with existing businesses. Factors that will affect the success of any potential acquisition or merger to be made by us include our ability to integrate acquired personnel, operations,
products and technologies into our organization effectively, to motivate personnel and to retain customers of acquired or merged businesses. We may not be able to identify suitable acquisition or merger opportunities, obtain necessary financing for
an acquisition on acceptable terms or successfully integrate acquired personnel and operations. While we have not experienced material disruption to our ongoing business or distraction to our management and employees as a result of past
acquisitions, we may experience such disruptions or distractions in the future.

We had an accumulated deficit of $331 million as of
December 31, 2010. If we fail to reach profitability and need to raise additional capital to fund our current and future operating plans or obtain such capital on unfavorable terms, then we may have to take further cost-cutting measures.

We have expended significant resources developing our facilities and funding commercialization activities. As a
result, we have incurred significant losses to date. We had net losses of $4.5 million, $1.5 million and $4.5 million for the years ended December 31, 2010, 2009 and 2008, respectively. We anticipate that our existing cash on hand will be
sufficient to fund our operations at least through the next twelve months. If we fail to reach cash flow self sufficiency, however, we may need to raise additional funds through the sale of equity, convertible debt or equity-linked securities and we
may have to further review our existing operations to determine new cost cutting measures, such as further consolidation of operational facilities and reductions in staff. We may not be able to raise additional funds or raise funds on terms that are
acceptable to us. If financing is not available to us in the future, or is not available on terms acceptable to us, we may not be able to fund our future operating needs. If we raise funds through equity or convertible securities, our stockholders
may experience dilution and our stock price may decline.

We may be held liable for any inaccuracies associated with our services, which
may require us to defend ourselves in costly litigation.

We provide forensic, family relationship and agricultural
testing services. Claims may be brought against us for incorrect identification of family relationships or other inaccuracies. Litigation of these claims in most cases is covered by our existing insurance policies. However, we could expend
significant funds during any litigation proceeding brought against us and litigation can be a distraction to management and our operations. If a court were to require us to pay damages that are not covered by our existing insurance policies, the
amount of such damages could significantly harm our financial condition, and even if covered, damages could exceed our insurance policy coverage limits. Our current professional liability insurance policy contains a maximum



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coverage limitation of $10 million. We have been named a defendant in a number of minor suits relating to our DNA testing services, including claims of incorrect results. However, none of the
outcomes of these suits have had a material adverse effect on our business to date.

Our improvement of existing technologies and our
ability to capture and develop future technologies to be utilized in our service offerings may not be commercially successful, which could adversely affect our revenues.

We are currently commercializing a limited number of services based on our technologies in DNA testing of humans. These services involve
uses of products, software and technologies that require validation for commercial application, and we cannot assure you that we or our customers will be able to recognize a cost-effective, commercial benefit in using our technology. In addition,
any assays we develop utilizing SNP analysis technology may not be useful in assisting in food safety testing. Only a limited number of companies have developed or commercialized services based on SNP technology to date. Accordingly, even if we or
our customers are successful in developing effective assays utilizing SNP technology for food safety testing, we cannot assure you that these discoveries will lead to commercially successful service offerings. If we fail to successfully develop our
SNP technologies or any services based on such technologies, we may not achieve a competitive position in the market.

We may be unable
to hire an adequate number of DNA analysts or successfully apply new technology.

Our growth and future operating
results will depend, in part, upon our ability to recruit an adequate number of trained DNA analysts both in the US and the UK. Our growth and future operating results will also depend, in part, upon our ability to apply new technologies to automate
and improve our DNA testing services to take advantage of new technologies. There can be no assurance that our development efforts will result in any additional commercially viable or successful improvements or efficiencies to our testing processes.
Any potential improvements to the testing process may require substantial additional investment and possibly regulatory approvals, prior to implementation. Our inability to recruit trained DNA analysts, attract laboratory personnel for our expanded
facilities in Dallas, Texas, and the UK, develop improvements to our testing processes, increase efficiencies, or achieve market acceptance of such improvements could have a material adverse effect on our business, financial condition and results of
operations.

Our ability to provide services may be seriously impaired by the occurrence of a natural disaster affecting any one or more
of our laboratories.

Should we experience the occurrence of a natural disaster affecting one or more of our
laboratories such that we would be unable to continue to provide services out of a particular facility for an extended period of time, and we were not able to scale up operations at our other facilities in order to continue to provide such services,
we would be at risk of losing significant contractual revenue from governmental agencies. Many of our governmental agency contracts allow for the agency to terminate the contract early if we become unable to continue to render such services for an
extended period of time, usually 90 days or more, for any reason, including the occurrence of a natural disaster. While we have multiple facilities, and may be able to shift operations from one facility to another in the event of a natural disaster,
thereby mitigating the effects thereof, we cannot assure you that any such transition will occur or be successful, particularly in light of our recent consolidation of our US facilities.

Although we carry insurance for recovery in the instance of a natural disaster, the limits of this insurance are $24 million, and it is
possible that our coverage will not be the same in all locations or that a loss in such an instance could exceed our ability to recover such costs.



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Our success will depend partly on our ability to operate without misappropriating the intellectual
property rights of others.

We may be sued for infringing, or may initiate litigation to determine that we are not
infringing, on the intellectual property rights of others. Intellectual property litigation is costly, and could adversely affect our results of operations. If we do not prevail in any intellectual property litigation, we might have to pay damages,
and we could be required to stop the infringing activity, or be required to obtain a license to or design around the intellectual property in question. If we are unable to obtain a required license on acceptable terms, or are unable to practice
non-infringing technologies or processes, we may be unable to sell some of our services, which would result in reduced revenues. We currently are a defendant in two patent litigation matters. Other than the foregoing, we are not aware of any
assertions that we are misappropriating the intellectual property rights of others. We cannot assure you that such matters will not result in significant costs to us.

The scope of our issued patents may not provide us with adequate protection of our intellectual property, which would harm our competitive position.

Any issued patents that cover our proprietary technologies may not provide us with substantial protection or be commercially beneficial to
us. In addition, we may not be able to obtain new patents for technologies and services material to our business. The issuance of a patent may be challenged with respect to its validity or its enforceability. The US Patent and Trademark Office (or a
court of appropriate jurisdiction), or any one of a number of foreign patent offices where we have pursued patent protection, may invalidate one or more of our patents. In addition, third parties may have patents of their own which could, if
asserted, prevent us from practicing our proprietary technologies, including the methods we use to conduct DNA testing. If we are otherwise unable to practice our patented technologies, we may not be able to commercialize our technologies or
services.

We may need to initiate lawsuits to protect or enforce our patents and other intellectual property rights, which could result
in the forfeiture of these rights.

In order to protect or enforce our patent rights, we may need to initiate patent
litigation against third parties. These lawsuits could be expensive, take significant time and divert managements attention from other business concerns. These lawsuits could result in the invalidation or a limitation in the scope of our
patents or forfeiture of the rights associated with our patents. We cannot assure you that we will prevail in any future litigation or that a court will not find damages or award other remedies in favor of the opposing party in any of these suits.
We also may not have the resources to aggressively protect and enforce existing protection. During the course of these suits, there may be public announcements of the results of hearings, motions and other interim proceedings or developments in the
litigation. Securities analysts or investors may perceive these announcements to be negative, which could cause the market price of our stock to decline.

Other rights and measures that we rely upon to protect our intellectual property may not be adequate to protect our services and could reduce our ability to compete in the market.

In addition to patents, we rely on a combination of trade secrets, copyright and trademark laws, non-disclosure
agreements and other contractual provisions and technical measures to protect our intellectual property rights. While we require employees, collaborators, consultants and other third parties to enter into confidentiality and/or non-disclosure
agreements where appropriate, any of the following could still occur:



| |  |  | the agreements may be breached;
| | - |  | -------------------------------



| |  |  | we may have inadequate remedies for any breach;
| | - |  | -----------------------------------------------



| |  |  | proprietary information could be disclosed to our competitors; or
| | - |  | -----------------------------------------------------------------



| |  |  | others may independently develop substantially equivalent proprietary information and techniques or otherwise gain access to our trade secrets or
disclose such technologies.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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To our knowledge, we have never been materially harmed by a breach under any of the
circumstances listed above. However, if our intellectual property is disclosed or misappropriated, it would harm both our ability to protect our rights and our competitive position. The pursuit of a remedy for such an alleged breach may require a
substantial amount of our resources, time, effort and expenses.

We may be required to record additional significant charges to earnings
if our goodwill becomes impaired.

Under generally accepted accounting principles in the US, we review our goodwill for
impairment each year as of December 31 and when certain events or changes in circumstances indicate that the carrying value of our goodwill may not be recoverable, we must record a charge against our earnings for the period in question. Our
goodwill may become impaired due to factors such as a decline in our stock price and market capitalization, reduced estimates of future cash flows and slower growth rates in our industry. Estimates of future cash flows are based on long-term
financial forecasts of our operations, which are subject to change if actual results differ materially from the estimates. If we are required to record a charge to earnings in our financial statements during a period in which an impairment of our
goodwill is determined to exist, our results of operations for the period would be negatively impacted.

Our ability to utilize our net
operating loss carryforwards and other tax benefits may be limited.

As of December 31, 2010, we had $247.6
million and $36.1 million of federal and state net operating loss, or NOL, carryforwards, respectively, available to offset future taxable income. Some of our federal and state NOL carryforwards have begun to expire. Utilization of our NOL
carryforwards to offset future taxable income, if any, may be substantially limited due to the change of ownership provisions in the Tax Reform Act of 1986, or the Act. The Act provides for a limitation on the annual use of NOL
carryforwards and research and development credits following certain ownership changes, as defined by the Act, which could significantly limit our ability to utilize or sell these carryforwards and research and development credits. In 2010, we
determined that certain ownerships changes occurred, as defined by the Act, in 1999 and 2001. As a result, only $220.5 million of our NOL is available for use at December 31, 2010. The remaining NOL carryover of $27.1 million will become
available for use in various amounts between 2011 and 2019. We may have experienced other ownership changes as a result of past financings that we have yet to determine and may experience others in connection with future financings. Accordingly, our
ability to utilize the aforementioned federal NOL carryforwards may be further limited.

Risks Associated with Our Common
Stock

Future issuance of our securities may dilute the ownership interests of our stockholders.

Our Board of Directors has the authority to issue shares of preferred stock and to determine the price, preferences, privileges and other
terms of those shares. Our Board of Directors may exercise this authority without any further approval of our stockholders. Additionally, if we need to raise additional funds through the sale of equity, convertible debt or equity-linked securities,
your percentage ownership in us on a diluted basis will be reduced. These transactions may dilute the value of our outstanding common stock. We may also issue securities that have rights, preferences and privileges senior to our common stock.

There are a limited number of stockholders who have significant control over our common stock, allowing them to have significant
influence over the outcome of all matters submitted to our stockholders for approval, which may conflict with the interests of our other stockholders.

Four of our principal stockholders (stockholders owning 5% or more of our common stock) beneficially owned approximately 41% of the outstanding shares of common stock at December 31, 2010, and such
stockholders will have significant influence over the outcome of all matters submitted to our stockholders for approval, including the election of our directors and other corporate actions. In addition, such influence by these stockholders could
have the effect of delaying or impeding a change in control and could have an adverse effect on the market price of our stock.



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In September 2010, we and one of our principal stockholders, Accipiter Capital
Management, LLC, or Accipiter executed an agreement in connection with the nomination of candidates for election to our Board of Directors. Pursuant to the agreement, Accipiter nominated Eugene I. Davis and Stefan Loren for election to our Board as
Class I directors with three-year terms ending in 2013. Mr. Davis and Dr. Loren were both elected as Class I directors at our 2010 annual meeting of stockholders, which was held on November 9, 2010.

We have various mechanisms in place that stockholders may not consider favorable, which may discourage takeover attempts and may prevent or
frustrate attempts by stockholders to change our direction or management.

Certain provisions of our certificate of
incorporation and by-laws, as well as Section 203 of the Delaware General Corporation Law and our adoption of a stockholder rights plan, may discourage, delay or prevent a change in control or the ability of stockholders to change our direction
or management, even if the changes would be beneficial to stockholders. These provisions:



| |  |  | authorize the issuance of blank check preferred stock that could be designated and issued by our Board of Directors to increase the number
of outstanding shares and thwart a takeover attempt;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | create a classified board of directors with staggered, three-year terms, which may lengthen the time required to gain control of our Board of
Directors;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | prohibit cumulative voting in the election of directors, which will allow a majority of stockholders to control the election of all directors;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | require super-majority voting to effect certain amendments to our certificate of incorporation and by-laws;
| | - |  | -----------------------------------------------------------------------------------------------------------



| |  |  | limit who may call special meetings of stockholders;
| | - |  | ----------------------------------------------------



| |  |  | prohibit stockholder action by written consent, which requires all stockholder actions to be taken at a meeting of stockholders; and
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------



| |  |  | establish advance notice requirements for nominations of candidates for election to our Board of Directors or for proposing matters that can be acted
upon by stockholders at stockholder meetings.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

In addition, pursuant to our stockholder rights plan, each
share of our common stock has an associated preferred share purchase right. The rights will not trade separately from the common stock until, and are generally exercisable only upon, the acquisition or the potential acquisition through tender offer
by a person or group of 15% or more of our outstanding common stock.

Our stock price has been, and likely will continue to be, volatile
and your investment may suffer a decline in value.

The market prices for securities of companies quoted on The NASDAQ
Stock Market, or NASDAQ, including our market price, have in the past been, and are likely to continue in the future to be, very volatile. Between January 1, 2009 and December 31, 2010, the sales price of our common stock ranged from a low
of $0.46 to a high of $2.19. The market price of our common stock has been, and likely will continue to be, subject to substantial volatility depending upon many factors, many of which are beyond our control, including:



| |  |  | announcements regarding the results of development efforts by us or our competitors;
| | - |  | ------------------------------------------------------------------------------------



| |  |  | announcements regarding the acquisition of technologies or companies by us or our competitors;
| | - |  | ----------------------------------------------------------------------------------------------



| |  |  | changes in our existing development or licensing arrangements or formation of new development or licensing arrangements;
| | - |  | ------------------------------------------------------------------------------------------------------------------------



| |  |  | the loss of existing business;
| | - |  | ------------------------------



| |  |  | our inability to secure new contractual relationships for our DNA testing services or new volume of testing samples at acceptable prices;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------



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##### Table of Contents

| |  |  | technological innovations or new service offerings developed by us or our competitors;
| | - |  | --------------------------------------------------------------------------------------



| |  |  | changes in our intellectual property portfolio;
| | - |  | -----------------------------------------------



| |  |  | developments or disputes concerning our proprietary rights;
| | - |  | -----------------------------------------------------------



| |  |  | issuance of new or changed securities analysts reports and/or recommendations applicable to us;
| | - |  | ------------------------------------------------------------------------------------------------



| |  |  | additions or departures of our key personnel;
| | - |  | ---------------------------------------------



| |  |  | our operating losses; and
| | - |  | -------------------------



| |  |  | continued economic uncertainty with respect to the valuation of certain technology companies and other market conditions.
| | - |  | -------------------------------------------------------------------------------------------------------------------------

The liquidity of our common stock could be adversely affected if we are delisted from the NASDAQ Global Market.

Pursuant to NASDAQ Marketplace Rule 5810, we are required to have a minimum bid price of at least $1.00. The closing price of our
common stock was below $1.00 per share from November 20, 2008 through April 29, 2009. The closing price of our common stock has remained above $1.00 per share since May 5, 2009 and we currently are in compliance with this listing
requirement. On March 11, 2011, the closing price of our common stock was $2.00.

There can be no assurance, however,
that the closing price of our common stock will remain above $1.00 per share or that we will otherwise be able to maintain the listing of our common stock on the NASDAQ Global Market. Delisting from NASDAQ would make trading our common stock
more difficult for investors, potentially leading to further declines in our share price. Without a NASDAQ listing, stockholders may have a difficult time getting a quote for the sale or purchase of our stock, the sale or purchase of our stock would
likely be made more difficult and the trading volume and liquidity of our stock would likely decline. Delisting from NASDAQ would also result in negative publicity and would also make it more difficult for us to raise additional
capital. The absence of such a listing may adversely affect the acceptance of our common stock as currency or the value accorded it by other parties. Further, if we are delisted, we would also incur additional costs under state blue sky
laws in connection with any sales of our securities. These requirements could severely limit the market liquidity of our common stock and the ability of our stockholders to sell our common stock in the secondary market.

If faced with delisting, we would have an opportunity to appeal NASDAQs determination or we may submit an application to transfer
the listing of our common stock to the NASDAQ Capital Market. Alternatively, if our common stock is delisted by NASDAQ, our common stock would be eligible to trade on the OTC Bulletin Board, another over-the-counter quotation system, or on the
pink sheets where an investor may find it more difficult to dispose of or obtain accurate quotations as to the market value of our common stock. We cannot assure you that our common stock, if delisted from the NASDAQ Global Market, will be
listed on a national securities exchange, a national quotation service, the OTC Bulletin Board or the pink sheets.

If we are
delisted from the NASDAQ Global Market and we are not able to transfer the listing of our common stock to the NASDAQ Capital Market, our common stock likely will become a penny stock. In general, regulations of the SEC define a
penny stock to be an equity security that is not listed on a national securities exchange and that has a market price of less than $5.00 per share, subject to certain exceptions. If our common stock becomes a penny stock, additional
sales practice requirements would be imposed on broker-dealers that sell such securities to persons other than certain qualified investors. For transactions involving a penny stock, unless exempt, a broker-dealer must make a special suitability
determination for the purchaser and receive the purchasers written consent to the transaction prior to the sale. In addition, the rules on penny stocks require delivery, prior to and after any penny stock transaction, of disclosures
required by the SEC. If our common stock were subject to the rules on penny stocks, the market liquidity for our common stock could be severely and adversely affected. Accordingly, the ability of holders of our common stock to sell their shares
in the secondary market may also be adversely affected.



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##### Table of Contents

Fluctuations in our operating results may negatively impact our stock price.

Our revenues and results of operations have fluctuated significantly in the past and these fluctuations are likely to continue in the
future due to a variety of factors, many of which are outside of our control. These factors include:



| |  |  | the timing of US federal funding for forensic DNA testing through the NIJ and that of state agencies;
| | - |  | -----------------------------------------------------------------------------------------------------



| |  |  | our ability to secure new contractual relationships for forensic, family relationship and agricultural testing or retain existing relationships upon
contract expirations;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the success of the consolidation of our US operations;
| | - |  | ------------------------------------------------------



| |  |  | the volume and timing of testing samples received in our laboratories for testing services;
| | - |  | -------------------------------------------------------------------------------------------



| |  |  | the number of trained DNA analysts which are available to process the samples for testing services;
| | - |  | ---------------------------------------------------------------------------------------------------



| |  |  | the number, timing and significance of new services introduced by our competitors;
| | - |  | ----------------------------------------------------------------------------------



| |  |  | our ability to develop, market and introduce new services on a timely basis;
| | - |  | ----------------------------------------------------------------------------



| |  |  | our ability to maintain and grow the volume of forensic testing services in the UK through directly providing our services to UK police forces and
winning awards under the National Procurement Plan;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | changes in the cost, quality and availability of intellectual property and components required to perform our services; and
| | - |  | ---------------------------------------------------------------------------------------------------------------------------



| |  |  | availability of commercial and government funding to researchers who use our services.
| | - |  | --------------------------------------------------------------------------------------

Fixed operating costs associated with our technologies and services, as well as personnel costs, marketing and sales programs and
overhead costs, account for a substantial portion of our operating expenses. We cannot adjust these expenses quickly in the short term. If our testing volumes and related pricing decline due to market pressure, our revenues will decline and we may
not be able to reduce our operating expenses accordingly. Our loss of revenues and failure to reduce operating expenses would harm our operating results. In addition, market and other conditions may require certain non-cash charges such as
impairment charges related to long-lived assets and restructuring charges to be recorded by us in future periods. If our operating results in any quarter or quarters fail to meet the expectations of public market analysts or investors, the market
price of our common stock is likely to fall. We cannot assure you that your investment in our common stock will not fluctuate significantly.

One or more of these factors or events could significantly harm our business and cause a decline in the price of our common stock in the public market.

Item 1B. UNRESOLVED STAFF COMMENTS

Not applicable.

Item 2. PROPERTIES

We lease an approximately 11,000 square foot facility in Princeton, New Jersey, which serves as our corporate headquarters. We lease an
approximately 26,000 square foot facility in Dallas, Texas and an approximately 17,000 square foot facility in Dayton, Ohio. We also lease an approximately 2,400 square foot facility in New Westminster, British Columbia. In addition, we lease a
total of approximately 48,000 square feet in two UK locations, Abingdon, which houses our UK headquarters and laboratories, and Chorley, our satellite facility that we set up to help service the work we were awarded under North West/South West and
Wales regional tender. We currently believe our facilities will be sufficient to serve our near term capacity needs.



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##### Table of Contents

Item 3. LEGAL PROCEEDINGS

On or about November 21, 2001, a complaint was filed in the United States District Court for the Southern District of New York naming
us as a defendant, along with certain of our former officers and underwriters. An amended complaint was filed on April 19, 2002. The complaint, as amended, purportedly was filed on behalf of persons purchasing our stock between May 4, 2000
and December 6, 2000, and alleges violations of Sections 11, 12(a)(2) and 15 of the Securities Act of 1933, as amended, and Sections 10(b) and 20(a) of the Securities Exchange Act of 1934, as amended, and Rule 10b-5 promulgated thereunder. The
amended complaint alleges that, in connection with the our May 5, 2000 initial public offering, or IPO, the defendants failed to disclose additional and excessive commissions purportedly solicited by and paid to the underwriter defendants in
exchange for allocating shares of our stock to preferred customers and alleged agreements among the underwriter defendants and preferred customers tying the allocation of IPO shares to agreements to make additional aftermarket purchases at
pre-determined prices. Plaintiffs claim that the failure to disclose these alleged arrangements made our registration statement on Form S-1 filed with the SEC in May 2000 and the prospectus, a part of the registration statement, materially false and
misleading. On or about July 15, 2002, we filed a motion to dismiss all of the claims against us and our former officers. On October 9, 2002, the Court dismissed without prejudice only our former officers, Dale R. Pfost and Donald R.
Marvin, from the litigation in exchange for our entering into a tolling agreement with plaintiffs executive committee. On February 19, 2003, we received notice of the Courts decision to dismiss the Section 10(b) claims against
us. Plaintiffs and the defendant issuers involved in related IPO securities litigation, including us, have agreed in principal on a settlement that, upon a one-time surety payment by the defendant issuers insurers, would release the defendant
issuers and the individual officers and directors from claims and any future payments or out-of-pocket costs. On March 10, 2005, the Court issued a memorandum and order (i) preliminarily approving the settlement, contingent on the
parties agreement on modifications of the proposed bar order in the settlement documents, (ii) certifying the parties proposed settlement classes, (iii) certifying the proposed class representatives for the purposes of the
settlement only and (iv) setting a further hearing for the purposes of (a) making a final determination as to the form, substance and program of notice of proposed settlement and (b) scheduling a public fairness hearing in order to
determine whether the settlement can be finally approved by the Court. On April 24, 2006, the Court held a fairness hearing and took the motion for final approval under advisement. On October 5, 2009, the Court granted the plaintiffs
motion for an order of final approval of the settlement, plan of allocation and certification of the class. Such settlement does not require any payment by us to the plaintiffs. The defendant issuers share of the settlement amount is funded by
the insurers. Notices of appeal have been filed by six groups of appellants. None of the notices state the basis for appeal.

In related proceedings against the underwriters, the United States Court of Appeals for the Second Circuit ruled on December 5, 2006
that the certification by the District Court for the Southern District of New York of class actions against the underwriters in six focus cases was vacated and remanded for further proceedings. In so doing, the Second Circuit ruled that
the cases pending on this appeal may not be certified as class actions. On April 6, 2007, the Second Circuit denied the plaintiffs petition for rehearing, and no further appeals have been taken.

As a result of the Second Circuits ruling, the plaintiffs and the issuers stipulated on June 22, 2007 that the Stipulation and
Agreement of Settlement with Defendant Issuers and Individuals, which was originally submitted to the Court on June 10, 2004, was terminated, which resolved the motion for final approval of the class action settlement with the issuers and
individual defendants. The Court entered the parties stipulation as an Order on June 25, 2007. As a result of these developments, the plaintiffs have filed amended complaints against the underwriters and focus case issuers and
individuals and are attempting to certify a class action.

In response to the amended complaints, the underwriters and
focus case issuers moved to dismiss the amended complaints. On March 26, 2008, the motion to dismiss was granted in part and denied in part. As a result, the Court will proceed with the plaintiffs amended complaints against
the underwriters and focus case issuers to determine whether class actions can be certified.



20



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##### Table of Contents

We are a defendant in litigation pending in the United States District Court for the
Southern District of New York entitled Enzo Biochem, Inc. et al. (Enzo) v. Amersham PLC, et al. (Amersham), filed in October 2002. By their complaint, plaintiffs allege that certain defendants (i) breached their distributorship agreements by
selling certain products for commercial development (which they allege was not authorized), (ii) infringed plaintiffs patents through the sale and use of certain products, and (iii) are liable for unfair competition and tortious
interference with contractual relations. We did not have a contractual relationship with plaintiffs, but we are alleged to have purchased the product at issue from one of the other defendants. We sold the business unit that was allegedly engaged in
the unlawful conduct. As a result, there is no relevant injunctive relief to be sought from us. The complaint seeks damages in an undisclosed amount. Most of the fact discovery in the case has been taken, and a Markman hearing to construe the patent
claims was conducted in early July 2005. On July 17, 2006, the Court ruled in our favor on its construction of the patents asserted against us, and the co-defendants, including us, moved for summary judgment on all claims against us in January
2007. A hearing on the defendants motions for summary judgment occurred on July 17-18, 2007, and the Court reserved ruling on the motions, taking them under advisement. Such matter has been delayed due to the death of the judge and the
assignment of a new judge.

In other litigation brought by Enzo against another defendant under the same patents asserted
against us, a Connecticut Federal Court has invalidated the patents asserted there and asserted against us in the New York case. That decision was reversed in part by the Court of Appeals on March 26, 2010. As a result of these
developments, the Enzo v. Amersham case has been stayed pending the outcome of the Connecticut Federal Court case.

On
February 12, 2010, a complaint was filed in the United States District Court for the Western District of Wisconsin by Genetic Technologies Limited naming us as a defendant, along with eight other companies. The complaint, entitled Genetic
Technologies Limited v. Beckman Coulter, Inc., et al., alleges that the defendants infringed U.S. Patent No. 5,612,179 through the sale and use of certain products and services. There is no request for injunctive relief by the plaintiff. We
have been served with a complaint and have filed an answer. Discovery is currently being conducted. We believe the allegations are without merit and intend to vigorously defend ourselves against such claims.

Additionally, we may have certain other claims against us arising from the normal course of our business. The ultimate resolution of such
matters, including those cases disclosed above, in the opinion of management, will not have a material effect on our financial position and liquidity, but could have a material impact on our results of operations for any reporting period.

Item 4. [REMOVED AND RESERVED]





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##### Table of Contents

PART II



|Item 5. | MARKET FOR REGISTRANTS COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUER PURCHASES OF EQUITY SECURITIES
|------- | ------------------------------------------------------------------------------------------------------------

Market Information

Our
common stock is traded on the NASDAQ Global Market under the symbol ORCH. The following table sets forth, for the periods indicated, the high and low sales prices for our common stock as reported by NASDAQ:



|               |  |              |      |  |     |   |      | 
|-------------- |  | ------------ | ---- |  | --- | - | ---- | 
|               |  | Common Stock |     
|               |  | High         |      |  | Low |  
|2010:          |  |              |      |  |     |   |      | 
|First Quarter  |  | $            | 1.95 |  |     | $ | 1.42 | 
|Second Quarter |  |              | 2.19 |  |     |   | 1.54 | 
|Third Quarter  |  |              | 1.72 |  |     |   | 1.35 | 
|Fourth Quarter |  |              | 2.14 |  |     |   | 1.35 | 
|2009:          |  |              |      |  |     |   |      | 
|First Quarter  |  | $            | .75  |  |     | $ | .46  | 
|Second Quarter |  |              | 1.73 |  |     |   | .58  | 
|Third Quarter  |  |              | 2.20 |  |     |   | 1.40 | 
|Fourth Quarter |  |              | 1.88 |  |     |   | 1.41 | 

On March 11,
2011, the closing sale price of our common stock was $2.00.

Stockholders

As of March 11, 2011, there were 349 stockholders of record.

Dividends

We have not paid dividends to our common stockholders since our
inception and do not plan to pay cash dividends in the foreseeable future, as we currently intend to retain earnings, if any, to finance our growth.



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##### Table of Contents

Item 6. SELECTED FINANCIAL DATA

The following table sets forth consolidated financial data with respect to the Company for each of the five years in the period
ended December 31, 2010. The selected financial data for each of the five years in the period ended December 31, 2010 have been derived from the audited consolidated financial statements of the Company. The consolidated financial
statements as of December 31, 2010 and 2009 and for the years ended December 31, 2010, 2009 and 2008, and the report thereon, are included elsewhere in this Annual Report on Form 10-K. The information below should be read in conjunction
with such consolidated financial statements (and notes thereon) and Managements Discussion and Analysis of Financial Condition and Results of Operations, included in Item 7.



|                                                                                               |  |                                       |        |   |      |   |        |      |  |   |        |   |  |      |        |   |  |   |         |  
|---------------------------------------------------------------------------------------------- |  | ------------------------------------- | ------ | - | ---- | - | ------ | ---- |  | - | ------ | - |  | ---- | ------ | - |  | - | ------- | -
|                                                                                               |  | Year ended December 31                |       
|                                                                                               |  | 2010                                  |        |   | 2009 |   |        | 2008 |  |   | 2007   |   |  | 2006 |       
|                                                                                               |  | (In thousands, except per share data) |       
|Consolidated statements of operations data:                                                    |  |                                       |        |   |      |   |        |      |  |   |        |   |  |      |        |   |  |   |         |  
|Total revenues                                                                                 |  | $                                     | 63,721 |   |      | $ | 59,062 |      |  | $ | 57,595 |   |  | $    | 60,303 |   |  | $ | 56,854  |  
|Operating expenses:                                                                            |  |                                       |        |   |      |   |        |      |  |   |        |   |  |      |        |   |  |   |         |  
|Cost of service revenues                                                                       |  |                                       | 41,823 |   |      |   | 38,549 |      |  |   | 40,287 |   |  |      | 40,230 |   |  |   | 39,705  |  
|Research and development                                                                       |  |                                       | 1,496  |   |      |   | 834    |      |  |   | 846    |   |  |      | 1,045  |   |  |   | 1,228   |  
|Marketing and sales                                                                            |  |                                       | 5,767  |   |      |   | 4,905  |      |  |   | 5,860  |   |  |      | 6,021  |   |  |   | 6,766   |  
|General and administrative                                                                     |  |                                       | 14,337 |   |      |   | 14,497 |      |  |   | 16,076 |   |  |      | 15,385 |   |  |   | 18,980  |  
|Restructuring                                                                                  |  |                                       | 1,725  |   |      |   | 161    |      |  |   |       |   |  |      | (75    | ) |  |   | 437     |  
|Amortization of intangible assets                                                              |  |                                       | 1,849  |   |      |   | 1,860  |      |  |   | 1,895  |   |  |      | 1,806  |   |  |   | 1,765   |  
|                                                                                               |  |                                       |        |   |      |   |        |      |  |   |        |   |  |      |        |   |  |   |         |  
|Total operating expenses                                                                       |  |                                       | 66,997 |   |      |   | 60,806 |      |  |   | 64,964 |   |  |      | 64,412 |   |  |   | 68,881  |  
|                                                                                               |  |                                       |        |   |      |   |        |      |  |   |        |   |  |      |        |   |  |   |         |  
|Operating loss                                                                                 |  |                                       | (3,276 | ) |      |   | (1,744 | )    |  |   | (7,369 | ) |  |      | (4,109 | ) |  |   | (12,027 | )
|Total other income (expense), net                                                              |  |                                       | 189    |   |      |   | 167    |      |  |   | 1,180  |   |  |      | 1,162  |   |  |   | 899     |  
|                                                                                               |  |                                       |        |   |      |   |        |      |  |   |        |   |  |      |        |   |  |   |         |  
|Loss before income taxes                                                                       |  |                                       | (3,087 | ) |      |   | (1,577 | )    |  |   | (6,189 | ) |  |      | (2,947 | ) |  |   | (11,128 | )
|Income tax benefit (expense)                                                                   |  |                                       | (1,435 | ) |      |   | 35     |      |  |   | 1,708  |   |  |      | (20    | ) |  |   | (143    | )
|                                                                                               |  |                                       |        |   |      |   |        |      |  |   |        |   |  |      |        |   |  |   |         |  
|Net loss                                                                                       |  | $                                     | (4,522 | ) |      | $ | (1,542 | )    |  | $ | (4,481 | ) |  | $    | (2,967 | ) |  | $ | (11,271 | )
|                                                                                               |  |                                       |        |   |      |   |        |      |  |   |        |   |  |      |        |   |  |   |         |  
|Basic and diluted net loss per share allocable to common stockholders                          |  | $                                     | (0.15  | ) |      | $ | (0.05  | )    |  | $ | (0.15  | ) |  | $    | (0.10  | ) |  | $ | (0.45   | )
|                                                                                               |  |                                       |        |   |      |   |        |      |  |   |        |   |  |      |        |   |  |   |         |  
|Shares used in computing basic and diluted net loss per share allocable to common stockholders |  |                                       | 29,935 |   |      |   | 29,935 |      |  |   | 29,935 |   |  |      | 29,583 |   |  |   | 24,892  |  
|                                                                                               |  |                                       |        |   |      |   |        |      |  |   |        |   |  |      |        |   |  |   |         |  



|                                                          |  |             |        |  |      |   |        |      |  |   |        |  |  |      |        |  |  |   |        | 
|--------------------------------------------------------- |  | ----------- | ------ |  | ---- | - | ------ | ---- |  | - | ------ |  |  | ---- | ------ |  |  | - | ------ | 
|                                                          |  | December 31 |       
|                                                          |  | 2010        |        |  | 2009 |   |        | 2008 |  |   | 2007   |  |  | 2006 |       
|Consolidated balance sheet data:                          |  |             |        |  |      |   |        |      |  |   |        |  |  |      |        |  |  |   |        | 
|Cash, cash equivalents and available-for- sale securities |  | $           | 19,821 |  |      | $ | 18,125 |      |  | $ | 14,998 |  |  | $    | 20,918 |  |  | $ | 24,144 | 
|Working capital                                           |  |             | 22,157 |  |      |   | 25,161 |      |  |   | 21,466 |  |  |      | 25,455 |  |  |   | 29,973 | 
|Total assets                                              |  |             | 52,513 |  |      |   | 52,842 |      |  |   | 50,649 |  |  |      | 62,129 |  |  |   | 60,616 | 
|Long-term debt, less current portion                      |  |             |       |  |      |   |       |      |  |   |       |  |  |      | 337    |  |  |   |       | 
|Total stockholders equity                                |  |             | 41,803 |  |      |   | 45,649 |      |  |   | 44,368 |  |  |      | 52,433 |  |  |   | 50,906 | 



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##### Table of Contents

|Item 7. | MANAGEMENTS DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS
|------- | -------------------------------------------------------------------------------------

This Managements Discussion and Analysis of Financial Condition and Results of Operations as of December 31, 2010 and for the
years ended December 31, 2010, 2009 and 2008 should be read in conjunction with our consolidated financial statements and related notes thereto and the selected financial data included elsewhere in this Annual Report on Form 10-K.

OVERVIEW

We are engaged
in the provision of DNA testing services that generate genetic profile information by analyzing an organisms unique genetic identity. We focus our business on DNA testing primarily for human identity and, to a lesser extent, agricultural and
other applications. In the human identity area, we principally provide DNA testing services for forensic, family relationship and, to a lesser extent, security applications. Forensic DNA testing is primarily used to confirm that a suspect committed
a particular crime, to exonerate an innocent person or to establish or maintain databases of individuals convicted of crimes or, in some instances, arrested in connection with crimes. We are also engaged in the provision of non-DNA forensic
laboratory services. Family relationship DNA testing is used to establish whether two or more people are genetically related. DNA testing is used by individuals and employers in security applications to establish or store a persons genetic
profile for identification purposes in the event of an emergency or accident. In agricultural applications, we provide DNA testing services for selective trait breeding.

We have operations in the United States, or US, and in the United Kingdom, or UK, and the majority of our current customers are based in these two countries. Our forensic, family relationship and security
DNA testing services are conducted in both the US and the UK, while all of our agricultural DNA testing services are conducted in the UK. Based on our review of publicly available information regarding contract sizes and competitor activity,
supplemented by industry publications and third-party market assessment data, we believe that the US and UK are two of the largest existing markets for DNA testing services today. In the US and UK, a significant amount of our current testing
activity is under established non-exclusive contracts with government agencies. These contracts are usually awarded through a sealed bid process and, when awarded, typically have a term from one to three years. We believe that our experience and
reputation as a reliable provider of services to government agencies is a valued credential that can be used in securing both new contracts and renewing existing contracts.

Our operations in the UK accounted for 63%, 50% and 46% of our total revenues for the years ended December 31, 2010, 2009 and 2008. Prior to 2009, a significant portion of our UK forensics revenues
were derived through a subcontracting agreement with a provider of analytical and diagnostic services. In 2007, UK police forces commenced soliciting competitive bids for all forensic testing services in a series of regional tenders. In February
2008, we were awarded, overall, a significant portion of the service packages we bid on in the North West/South West and Wales regional tender. We were awarded work from nine of the fourteen police forces that participated in this tender. Under the
terms of the award, we are providing forensic services, including DNA testing of database crime scene samples, forensic casework and database testing services under the UKs Police and Criminal Evidence Act, or PACE, for multiple police forces
that collectively tendered their work. In August 2010, such contracts were extended for a two-year term ending in 2013. In October 2010, we commenced work for five UK police forces in the East Midlands region under three-year contracts awarded under
the National Forensic Procurement Project. Under the terms of the award, we are conducting DNA analysis of crime scene samples for submission to the UKs National DNA Database. We believe that the actions we have taken to date have enabled us
to successfully transition from our prior reliance on revenues derived from acting as a subcontractor to directly providing these services to government agencies and police forces in the UK.

Our operations in the US accounted for 37%, 50% and 54% of our total revenues for the years ended December 31, 2010, 2009 and 2008,
respectively. We continue to experience price competition in our forensics and paternity testing businesses. We are focused on improving our operational execution to increase throughput in our laboratories and lower aggregate operating costs. For
instance, in our forensics business we have reduced



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our sample processing time and decreased the number of CODIS samples that need to be retested. In October 2009, we announced a consolidation of our East Lansing, Michigan paternity testing
operations into our Dayton, Ohio facility, which we completed during the quarter ended March 31, 2010. In January 2010, we announced a planned consolidation of our Nashville, Tennessee forensic DNA testing facility into our Dallas, Texas
facility, which we completed in the quarter ended September 30, 2010. We achieved these consolidations within the time frames and range of costs previously disclosed and our operating costs have been favorably impacted by the consolidation of
these testing facilities. We currently are focused on achieving continued operational efficiencies, cost reductions and increased scalability from these consolidations.

Operating Highlights

Our revenues are predominately generated from DNA
testing services provided to our customers. Our costs and expenses include costs of service revenues, research and development expenses, marketing and sales expenses, general and administrative expenses, amortization expense and other income and
expense. Costs of service revenues consist primarily of salaries and related personnel costs, laboratory supplies, fees paid for the collection of samples, depreciation and facility expenses. Research and development expenses consist primarily of
salaries and related costs, laboratory supplies and other expenses related to the design, development, testing and enhancement of our services. Marketing and sales expenses consist of salaries and benefits for marketing and sales personnel within
our organization and all related costs of selling and marketing our services. General and administrative expenses consist primarily of salaries and related expenses for executive, finance and administrative personnel, professional fees, insurance
and other corporate expenses.

Overall, for the year ended December 31, 2010 as compared to the year ended
December 31, 2009, total revenues increased approximately 8% while gross margin, as percentage of service revenues, remained at approximately 34% for both years ended. For the year ended December 31, 2010, as compared to 2009, our UK
revenues were unfavorably impacted by approximately 2% as a result of the exchange rate movement of the British pound as compared to the US dollar. Excluding the adverse effect of exchange rate movements, in local currency terms we experienced an
increase in revenue of 37%, primarily due to increases in forensics, paternity and immigration testing services, partially offset by continued decreases in agriculture revenues. We experienced revenue increases in our UK forensic, paternity and
immigration testing services and in our US CODIS and individual state database testing services. The significant increase in revenues in our US CODIS testing services was offset by a significant decrease in revenues in our forensic casework business
and, to a lesser extent, a decrease in our paternity testing business. Gross margin, as a percentage of service revenues, for the year ended December 31, 2010 as compared to 2009 remained relatively constant, primarily a result of higher
forensic volume in our UK operations, offset by lower volume and price decreases in our US-based testing services. Cost of service revenues increased due to higher personnel costs and lab supplies as a result of the increased volume in our UK
operations, partially offset by decreased costs in the US. For the year ended December 31, 2010, our operating expenses, other than cost of service revenues, increased by approximately 13% as compared to the year ended December 31, 2009,
as a result of restructuring expenses, as well as increased research and development and sales and marketing expenses, partially offset by decreased general and administrative expenses.



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##### Table of Contents

RESULTS OF OPERATIONS

Years ended December 31, 2010 and 2009

The following table sets forth a
year-over-year comparison of the components of our net loss for the years ended December 31, 2010 and 2009:



|                                  |  |                |        |   |      |   |        |          |  |   |          |   |  |  |       |  
|--------------------------------- |  | -------------- | ------ | - | ---- | - | ------ | -------- |  | - | -------- | - |  |  | ----- | -
|                                  |  | 2010           |        |   | 2009 |   |        | $ Change |  |   | % Change |  
|                                  |  | (In thousands) |        |   |      |  
|Total revenues                    |  | $              | 63,721 |   |      | $ | 59,062 |          |  | $ | 4,659    |   |  |  | 8     | %
|Cost of service revenues          |  |                | 41,823 |   |      |   | 38,549 |          |  |   | 3,274    |   |  |  | 8     |  
|Research and development          |  |                | 1,496  |   |      |   | 834    |          |  |   | 662      |   |  |  | 79    |  
|Marketing and sales               |  |                | 5,767  |   |      |   | 4,905  |          |  |   | 862      |   |  |  | 18    |  
|General and administrative        |  |                | 14,337 |   |      |   | 14,497 |          |  |   | (160     | ) |  |  | (1    | )
|Restructuring expense             |  |                | 1,725  |   |      |   | 161    |          |  |   | 1,564    |   |  |  | >100  |  
|Amortization of intangible assets |  |                | 1,849  |   |      |   | 1,860  |          |  |   | (11      | ) |  |  | (1    | )
|Total other income, net           |  |                | 189    |   |      |   | 167    |          |  |   | 22       |   |  |  | 13    |  
|Income tax benefit (expense)      |  |                | (1,435 | ) |      |   | 35     |          |  |   | (1,470   | ) |  |  | >(100 | )
|Net loss                          |  |                | (4,521 | ) |      |   | (1,542 | )        |  |   | (2,979   | ) |  |  | >100  |  

Revenues

Total revenues for the year ended December 31, 2010 of $63.7 million represented an increase of approximately $4.7 million, or
approximately 8%, as compared to revenues of $59.1 million for 2009.

Revenues from our UK-based testing services of $40.0
million for the year ended December 31, 2010 increased by $10.5 million, or approximately 35%, compared to $29.5 million to the comparable period in 2009. For the year ended December 31, 2010, as compared to the comparable period in 2009,
our UK revenues were unfavorably impacted by approximately 2% as a result of the exchange rate movement of the British pound as compared to the US dollar. Our UK-based revenue increase was primarily driven by a significant increase in forensics
revenues, as work awarded under the North West/South West and Waless regional tender and other government work has replaced and surpassed revenues previously generated under our expired subcontracting agreement. One UK government customer
accounted for approximately 25% of our total revenues in 2010. We also experienced revenue increases in paternity and immigration testing services for the year ended December 31, 2010, as compared to the comparable period in 2009.

Prior to 2009, a significant portion of our UK forensics revenues were derived through a subcontracting agreement with a provider of
analytical and diagnostic services. In 2007, UK police forces commenced soliciting competitive bids for all forensic testing services in a series of regional tenders. In February 2008, we were awarded, overall, a significant portion of the service
packages we bid on in the North West/South West and Wales regional tender. We were awarded work from nine of the fourteen police forces that participated in this tender. Under the terms of this award, we are providing forensic services, including
DNA testing of database crime scene samples, forensic casework and database testing services under PACE for multiple police forces that collectively tendered their work. In August 2010, such contracts were extended for a two-year term ending in
2013. In October 2010, we commenced work for five UK police forces in the East Midlands region under three-year contracts awarded under the National Forensic Procurement Project. Under the terms of this award, we are conducting DNA analysis of crime
scene samples for submission to the National DNA Database. We believe that the actions we have taken to date have enabled us to successfully transition from our prior reliance on revenues derived from acting as a subcontractor to directly providing
these services to government agencies and police forces in the UK.

Our US service revenues for the year ended
December 31, 2010 of $23.7 million decreased by $4.9 million, or approximately 17%, compared to $28.6 million for the comparable period in 2009, primarily as a result of a decrease in forensics casework and paternity testing services due, in
part, to budgetary constraints at the state and local levels. This decrease was partially offset by an increase in our US CODIS and individual state database testing services.



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##### Table of Contents

During the years ended December 31, 2010 and 2009, we recognized $27 thousand and $985
thousand, respectively, in other revenues, specifically license revenues.

Cost of Service Revenues

Cost of service revenues was $41.8 million, or approximately 66% of service revenues, for the year ended December 31, 2010, compared
to $38.5 million, or approximately 66% of service revenues, for the year ended December 31, 2009. For the year ended December 31, 2010, as compared to the comparable period in 2009, our UK cost of service revenues were favorably impacted
by approximately 2% as a result of the exchange rate movement of the British pound as compared to the US dollar. Cost of service revenues for the year ended December 31, 2010, as compared to the comparable period in 2009, increased due to
higher personnel and lab supplies as a result of increased volume in our UK operations, partially offset by decreased costs in the US as a result of lower volume. Our gross margin percentage remained constant, primarily as a result of higher volume
in our UK operations, offset by price and volume decreases in our US-based testing services. In the quarter ended March 31, 2010, we completed the consolidation of our East Lansing, Michigan paternity testing operations into our Dayton, Ohio
facility. In the quarter ended September 30, 2010, we completed the consolidation of our Nashville, Tennessee forensic DNA testing facility into our Dallas, Texas facility. Our operating costs have been favorably impacted by the consolidation
of these testing facilities. We currently are focused on achieving continued operational efficiencies, cost reductions and increased scalability from these consolidations.

Research and Development

Research and development expenses for the
year ended December 31, 2010 were $1.5 million, an increase of $662 thousand, as compared to $834 thousand during 2009. This increase in research and development expenses was primarily due to the costs associated with the establishment of a
CODIS laboratory at our Dallas, Texas testing facility.

Marketing and Sales

Marketing and sales expenses for the year ended December 31, 2010 were $5.8 million, an increase of $862 thousand as compared to $4.9
million during the prior year. This increase in marketing and sales expenses was primarily due to increased program costs in the US.

General and Administrative

General and administrative expenses for the year ended December 31, 2010 were $14.3 million, a decrease of $162 thousand as compared to $14.5 million during 2009. The decrease in general and
administrative expenses is primarily due to decreased legal and professional fees, partially offset by increased employee benefit program expenses.

Restructuring

During the year ended December 31, 2010, we
recognized $1.7 million in restructuring expenses related to the consolidation of our East Lansing, Michigan paternity testing operations into our Dayton, Ohio facility and the consolidation of our Nashville CODIS testing operation into our Dallas,
Texas facility, an increase of $1.6 million as compared to $161 thousand during 2009. We announced the planned East Lansing consolidation in October 2009 and completed this consolidation during the quarter ended March 31, 2010. We announced the
planned Nashville consolidation in January 2010, and completed this consolidation during the quarter ended September 30, 2010. The expenses in 2010 relate primarily to employee severance costs and facility closure costs.

In connection with these consolidations, we expect to incur aggregate restructuring charges and cash expenditures of $1.8 million to $2.3
million, the majority of which already have been incurred. We achieved these consolidations within the time frames and range of costs previously disclosed. Such charges and



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##### Table of Contents

expenditures include: severance and retention bonuses for employees in the range of $990 thousand to $1.2 million; relocation in the range of $135 thousand to $185 thousand; recruiting and
training costs in connection with the transfer of work of approximately $100 thousand; lease termination costs in the range of $200 thousand to $300 thousand; and equipment relocation and reinstallation costs in the range of $375 thousand to $485
thousand.

A summary of the restructuring activity in 2010 is as follows (in thousands):



|                                                    |  |       |        |  
|--------------------------------------------------- |  | ----- | ------ | -
|                                                    |  | Total |       
|Restructuring liability as of December 31, 2009     |  | $     | 142    |  
|Charge recorded in the year ended December 31, 2010 |  |       | 1,725  |  
|Cash payments in the year ended December 31, 2010   |  |       | (1,577 | )
|                                                    |  |       |        |  
|Restructuring liability as of December 31, 2010     |  | $     | 290    |  
|                                                    |  |       |        |  

Amortization of Intangible Assets

During the years ended December 31, 2010 and 2009, we recorded amortization of intangible assets of $1.8 million and $1.9 million, respectively.

Income Tax Expense

During the year ended December 31, 2010, we recognized a current foreign tax expense of $1.3 million and deferred foreign tax expense
of $222 thousand, primarily for our profitable business in the UK and we recognized $257 thousand in federal and state deferred taxes. In addition, we recorded a tax benefit of $39 thousand relating to the recovery of Federal Research Credits and
$282 thousand associated with the sale of some of our state net operating loss, or NOL, carryforwards. No tax benefit was recorded relating to our US business losses as management deemed that it was not likely than such tax benefit would be
realized.

During the year ended December 31, 2009, we recorded an income tax benefit of $35 thousand. In addition, we
recognized a current foreign tax expense of $168 thousand. Included in the expense is a current benefit of $192 thousand relating to certain allowances and deductions taken on our tax returns.

Net Loss

For the
year ended December 31, 2010, we reported a net loss of $4.5 million, which represented an increase of more than 100% as compared to a net loss of $1.5 million for the year ended December 31, 2009.

Years ended December 31, 2009 and 2008

The following table sets forth a year-over-year comparison of the components of our net loss for the years ended December 31, 2009 and 2008:



|                                  |  |                |        |   |      |   |        |          |  |   |          |   |  |  |     |  
|--------------------------------- |  | -------------- | ------ | - | ---- | - | ------ | -------- |  | - | -------- | - |  |  | --- | -
|                                  |  | 2009           |        |   | 2008 |   |        | $ Change |  |   | % Change |  
|                                  |  | (In thousands) |        |   |      |  
|Total revenues                    |  | $              | 59,062 |   |      | $ | 57,595 |          |  | $ | 1,467    |   |  |  | 3   | %
|Cost of service revenues          |  |                | 38,549 |   |      |   | 40,287 |          |  |   | (1,738   | ) |  |  | (4  | )
|Research and development          |  |                | 834    |   |      |   | 846    |          |  |   | (12      | ) |  |  | (1  | )
|Marketing and sales               |  |                | 4,905  |   |      |   | 5,860  |          |  |   | (955     | ) |  |  | (16 | )
|General and administrative        |  |                | 14,497 |   |      |   | 16,076 |          |  |   | (1,579   | ) |  |  | (10 | )
|Restructuring expense             |  |                | 161    |   |      |   |       |          |  |   | 161      |   |  |  | 100 |  
|Amortization of intangible assets |  |                | 1,860  |   |      |   | 1,895  |          |  |   | (35      | ) |  |  | (2  | )
|Total other income, net           |  |                | 167    |   |      |   | 1,180  |          |  |   | (1,013   | ) |  |  | (86 | )
|Income tax benefit (expense)      |  |                | 35     |   |      |   | 1,708  |          |  |   | (1,673   | ) |  |  | (98 | )
|Net loss                          |  |                | (1,542 | ) |      |   | (4,481 | )        |  |   | 2,939    |   |  |  | 66  |  



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##### Table of Contents

Revenues

Total revenues for the year ended December 31, 2009 of $59.1 million represented an increase of approximately $1.5 million, or approximately 3%, as compared to revenues of $57.6 million for 2008.

Our US service revenues for the year ended December 31, 2009 of $28.6 million decreased by approximately $2.4 million,
or approximately 8%, as compared to $31.0 million for 2008, primarily due to a significant decrease in CODIS business and individual state database testing services from 2008, and lower average selling price per sample as a result of significant
price competition, as well as decreased revenues from paternity testing services.

Revenues from our UK-based testing services
increased by $3.2 million, or approximately 12%, to $29.5 million for the year ended December 31, 2009, as compared to $26.4 million for 2008. For the year ended December 31, 2009, as compared to 2008, our UK revenues were unfavorably
impacted by approximately 15% as a result of the exchange rate movement of the British pound as compared to the US dollar. Despite the adverse effect of exchange rate movements, our UK-based revenue increase was driven by an increase in forensics
revenues, as work awarded under the North West/South West and Waless regional tender and other work has replaced and surpassed revenues previously generated under our subcontracting agreement.

During the years ended December 31, 2009 and 2008, we recognized $985 thousand and $230 thousand, respectively, in other revenues,
specifically license revenues attributable to a patent license agreement.

Cost of Service Revenues

Cost of service revenues was $38.5 million, or approximately 66% of service revenues, for the year ended December 31, 2009, compared
to $40.3 million, or approximately 70% of service revenues, for the year ended December 31, 2008. For year ended December 31, 2009, as compared to the comparable period in 2008, our UK cost of service revenues were favorably impacted by
approximately 15% as a result of the exchange rate movement of the British pound as compared to the US dollar. In the US, cost of service revenues for year ended December 31, 2009, as compared to the comparable period in 2008, decreased due to
lower personnel costs and to lower lab supply costs as a result of process improvements. Our gross margin percentage increased by approximately four percentage points from 30% for year ended December 31, 2008 to 34% for the year ended
December 31, 2009. This increase is a result of added sample volumes for our forensics testing services in the UK, productivity enhancements in the US and the UK, as well as reductions in personnel and supply expenses in the US. On
October 20, 2009, we announced a planned consolidation of our East Lansing, Michigan paternity testing operations into our Dayton, Ohio facility. On January 14, 2010, we announced a planned consolidation of our Nashville, Tennessee
forensic DNA testing facility into our Dallas, Texas facility. We believe these consolidations may lead to additional operational efficiencies, plant and equipment cost reductions and increased scalability.

Research and Development

Research and development expenses for the year ended December 31, 2009 were $834 thousand, a decrease of $12 thousand, as compared to $846 thousand during 2008. The decrease in research and
development expenses was primarily due to the impact of the exchange rate movement of the British pound as compared to the US dollar.

Marketing and Sales

Marketing and sales expenses for the year ended December 31, 2009 were $4.9 million, a decrease of $955 thousand as compared to $5.9 million during the prior year. The decrease in marketing and sales
expenses was primarily due to decreased personnel, travel and postage costs and the impact of the exchange rate movement of the British pound as compared to the US dollar.



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##### Table of Contents

General and Administrative

General and administrative expenses for the year ended December 31, 2009 were $14.5 million, a decrease of $1.6 million as compared
to $16.1 million during 2008. The decrease in general and administrative expenses is primarily due to decreased professional fees, including non-recurring legal fees related to a sizable state paternity contract that was awarded to us and protested
by a competitor in 2008 and the impact of the exchange rate movement of the British pound as compared to the US dollar.

Restructuring

During the year ended December 31, 2009, we recognized $161 thousand in restructuring expenses related to the
consolidation of our East Lansing, Michigan paternity testing operations into our Dayton, Ohio facility. We announced this planned consolidation on October 20, 2009 and expect to complete this consolidation and close the East Lansing facility
by July 1, 2010. The expenses in 2009 relate primarily to employee severance costs and facility closure costs.

We
currently expect to incur restructuring charges and cash expenditures in connection with this consolidation of $775 thousand to $1.0 million in the aggregate, which includes: severance and retention bonuses for employees in the range of $450
thousand to $550 thousand; relocation costs for employees relocating from the East Lansing facility in the range of $50 thousand to $75 thousand; recruiting and training costs for the Dayton facility in connection with the transfer of work from the
East Lansing facility of approximately $50 thousand; lease termination costs in the range of $150 thousand to $200; thousand and equipment relocation and reinstallation costs in the range of $75 thousand to $125 thousand. A substantial portion of
these charges and expenditures are expected to be reported in first and second quarters of 2010. We currently expect to offset these restructuring charges and expenditures through annual cost savings of approximately $1.0 million from operational
efficiencies, plant and equipment cost reductions and increased scalability.

A summary of the restructuring activity in 2009
is as follows (in thousands):



|                                                    |  |       |     | 
|--------------------------------------------------- |  | ----- | --- | 
|                                                    |  | Total |    
|Restructuring liability as of December 31, 2008     |  | $     |    | 
|Charge recorded in the year ended December 31, 2009 |  |       | 142 | 
|Cash payments in the year ended December 31, 2009   |  |       |    | 
|                                                    |  |       |     | 
|Restructuring liability as of December 31, 2009     |  | $     | 142 | 
|                                                    |  |       |     | 

On January 14, 2010 we announced the consolidation of our Nashville, Tennessee forensic DNA testing
facility into our Dallas, Texas facility. We expect to complete this consolidation by August 31, 2010. We currently expect to incur restructuring charges and cash expenditures in connection with this consolidation of $1.0 million to $1.3
million in the aggregate, which includes: severance and retention bonuses for employees in the range of $540 thousand to $680 thousand; relocation costs for employees relocating from the Nashville facility in the range of $85 thousand to $110
thousand; recruiting and training costs in our Dallas facility in connection with the transfer of work from the Nashville facility of approximately $50 thousand; lease termination costs in the range of $50 thousand to $100 thousand and equipment
relocation and reinstallation costs in the range of $300 thousand to $360 thousand. A substantial portion of these charges are expected to be reported in the second, third and fourth quarters of 2010. We currently expect to offset these
restructuring charges and expenditures through annual cost savings of approximately $1.4 million from operational efficiencies, plant and equipment cost reductions and increased scalability.

Amortization of Intangible Assets

During each of the years ended
December 31, 2009 and 2008, we recorded $1.9 million of amortization expense.



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##### Table of Contents

Income Tax Expense

During the years ended December 31, 2009 and 2008, we recorded an income tax benefit of $35 thousand and $1.7 million, respectively.

During 2009, we recognized a current foreign tax expense of $168 thousand. Included in this expense is a current benefit of $192 thousand
relating to certain allowances and deductions taken on our tax returns.

For the year ended December 31, 2008, we
recognized a current foreign tax benefit of $193 thousand, including a tax benefit of $175 thousand due to a write down in our unrecognized income tax benefits, and a deferred foreign tax benefit of $47 thousand, primarily for our business in the
UK; as well as a tax benefit of $1.5 million associated with the sale of some of our state NOL carryforwards. No tax benefit was recorded relating to our US business losses as management deemed that it was not likely than such tax benefit
would be realized.

Net Loss

For the year ended December 31, 2009, we reported a net loss of $1.5 million, which represented a decrease of 66% as compared to a net loss of $4.5 million for the year ended December 31, 2008.

LIQUIDITY AND CAPITAL RESOURCES

As of December 31, 2010, we had $19.8 million in cash, cash equivalents and available-for-sale securities as compared to $18.1 million as of December 31, 2009. Working capital decreased to $22.2
million at December 31, 2010 from $25.2 million at December 31, 2009. This decrease in working capital was primarily a result of the increase in our net loss, as well as an increase in accounts payable and accrued expenses during 2010. As
of December 31, 2010, we had no short or long-term debt obligations

Sources of Liquidity

Our primary sources of liquidity have been issuances of our securities and other capital raising activities.

The following table sets forth a year-over-year comparison of the components of our liquidity and capital resources for the years ended
December 31, 2010 and 2009:



|                            |  |                |        |   |         |   |         |         |  |   |       |  |  |  |      |  
|--------------------------- |  | -------------- | ------ | - | ------- | - | ------- | ------- |  | - | ----- |  |  |  | ---- | -
|                            |  | (In thousands) |        |   | $Change |   |         | %Change | 
|                            |  | 2010           |        |   | 2009    |   |         |        
|Cash provided by (used in): |  |                |        |   |         |   |         |         |  |   |       |  |  |  |      |  
|Operating activities        |  | $              | 4,862  |   |         | $ | 3,639   |         |  | $ | 1,223 |  |  |  | 34   | %
|Investing activities        |  |                | (6,314 | ) |         |   | (10,420 | )       |  |   | 4,106 |  |  |  | (39  | )
|Financing activities        |  |                |       |   |         |   | (338    | )       |  |   | 338   |  |  |  | (100 | )

Net cash provided by
operations for the year ended December 31, 2010 was $4.9 million, compared with net cash provided by operations of approximately $3.6 million for the prior year. The change in operating cash flows was mainly a result of a decrease in our
accounts receivable and an increase in our accrued expenses and accounts payable for the year ended December 31, 2010 as compared to 2009. Investing activities during the year ended December 31, 2010 of $6.3 million primarily consisted of
$9.2 million for the purchase of available for sale securities, as well as $2.9 million in capital expenditures, as compared to investing activities during the year ended December 31, 2009 of $10.4 million, which primarily consisted of $9.6
million for the purchase of available for sale securities, and $793 thousand in capital expenditures. There were no financing activities during the year ended December 31, 2010. Financing activities during the year ended December 31, 2009
primarily consisted of repayment of debt obligations of $338 thousand.



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##### Table of Contents

ReliaGene Debt

As part of the acquisition of ReliaGene on October 31, 2007, we assumed $948 thousand in debt comprised of a line of credit and various notes payable with outstanding balances of $260 thousand and
$688 thousand, respectively. The line of credit was fully paid off during 2008 with a then outstanding balance of $170 thousand. The notes payable, which were secured by ReliaGenes equipment, had interest rates ranging from 4.50% to 8.50% and
maturity dates ranging from June 30, 2009 through September 5, 2011. In April 2009, we fully paid off the ReliaGene notes payable, along with all accrued interest.

Expected Uses of Liquidity in 2011

Throughout 2011, we plan to
continue making investments in our business. We expect the following to be significant uses of liquidity: cost of service revenues, salaries and related personnel costs, laboratory supplies, fees for the collection of samples, facility expenses,
marketing expenses and general and administrative costs. Actual expenditures may vary substantially from our estimates. We expect to make capital expenditures related to the expansion of our UK facilities in Abingdon and Chorley. In addition, we may
make additional investments in future acquisitions of businesses or technologies which would increase our capital expenditures.

We believe that our existing cash on hand will be sufficient to fund our operations at least through the next twelve months. We may need
to raise additional capital through debt, equity or equity-linked financing to fund future growth opportunities or to operate our ongoing business activities if our future results of operations fall below our expectations. However, we may not be
able to raise additional funds or raise funds on terms that are acceptable to us. If future financing is not available to us, or is not available on terms acceptable to us, we may not be able to fund our future needs. If we raise funds through
equity or convertible securities, our stockholders may experience dilution and our stock price may decline.

We cannot assure
you that our business or operations will not change in a manner that would consume available resources more rapidly than anticipated. We also cannot assure you that we will not require substantial additional funding before we can achieve profitable
operations. We also may need additional capital if we seek to acquire other businesses or technologies.

Contractual Obligations and
Commercial Commitments

We maintained multiple contractual commitments as of December 31, 2010 which will support
our future business operations. Such commitments relate to non-cancelable operating lease arrangements, debt obligations and a lease guarantee. We have identified and quantified the most significant of these commitments in the following table.



|                                |  |                        |       |  |                 |   |       |          |  |   |          |  |  |                  |     |  |  |   |     | 
|------------------------------- |  | ---------------------- | ----- |  | --------------- | - | ----- | -------- |  | - | -------- |  |  | ---------------- | --- |  |  | - | --- | 
|                                |  | Payments due by period |      
|                                |  | Total                  |       |  | Less Than1 Year |   |       | 1-3Years |  |   | 3-5Years |  |  | More Than5 Years |    
|                                |  | (In thousands)         |      
|Contractual obligations:        |  |                        |       |  |                 |   |       |          |  |   |          |  |  |                  |     |  |  |   |     | 
|Operating lease obligations (1) |  | $                      | 4,954 |  |                 | $ | 1,593 |          |  | $ | 1,878    |  |  | $                | 988 |  |  | $ | 495 | 
|                                |  |                        |       |  |                 |   |       |          |  |   |          |  |  |                  |     |  |  |   |     | 
|Total contractual obligations   |  | $                      | 4,954 |  |                 | $ | 1,593 |          |  | $ | 1,878    |  |  | $                | 988 |  |  | $ | 495 | 
|                                |  |                        |       |  |                 |   |       |          |  |   |          |  |  |                  |     |  |  |   |     | 



|(1) | Such amounts represent future minimum rental commitments for office space and equipment leased under noncancelable operating lease arrangements.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------

Off-Balance Sheet Arrangements

None.



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Sale of and Limitation on the Use of Our NOL Carryforwards

We sold certain NOL carryforwards in accordance with the State of New Jerseys Corporation Business Tax Benefit Certificate Transfer
program, or the Program. During 2010 and 2008, we completed the sale of $15.4 million and $21.3 million, respectively, of New Jersey NOL carryforwards. We generated tax benefits of $282 thousand and $749 thousand for 2010 and 2008, respectively. We
were not eligible for this program in 2009.

As of December 31, 2010, we have $247.6 million and $36.1 million of federal
and state NOL carryforwards, respectively, available to offset future taxable income. Some of the federal and state NOL carryforwards that we have generated or acquired have begun to expire. Utilization of our NOL carryforwards to offset future
taxable income, if any, may be substantially limited due to the change of ownership provisions in the Tax Reform Act of 1986, or the Act. The Act provides for a limitation on the annual use of NOL carryforwards and research and
development credits following certain ownership changes, as defined by the Act, which could significantly limit our ability to utilize or sell these carryforwards and research and development credits. In 2010, we determinedthat ownerships changes
occurred, as defined by the Act, in 1999 and 2001. As a result, only $220.5 million of our NOL is available for use at December 31, 2010, while the remaining NOL carryover of $27.1 million will become available for use in various amounts
between 2011 and 2019. We may have experienced other ownership changes as a result of past financings that we have yet to determine and may experience others in connection with future financings. Accordingly, our ability to utilize the
aforementioned federal NOL carryforwards may be further limited.

At December 31, 2010, we had federal and New Jersey
research and development tax credits and federal foreign tax credit carryforwards of $3.8 million, which will begin expiring in 2016.

Critical Accounting Policies

Our critical accounting policies are as follows:



| |  |  | revenue recognition
| | - |  | -------------------



| |  |  | stock-based compensation
| | - |  | ------------------------



| |  |  | valuation of goodwill and other long-lived assets
| | - |  | -------------------------------------------------



| |  |  | income taxes
| | - |  | ------------

Revenue
Recognition

We recognize DNA laboratory services revenues at the time test results are completed and reported, persuasive
evidence of an arrangement exists, the price to the buyer is fixed or determinable and collectibility is reasonably assured. Deferred revenues represent the unearned portion of payments received in advance of tests being completed and reported.
Unbilled receivables represent revenue which has been earned on completed and reported tests, but has not been billed to the customer. Revenues from license arrangements, including license fees creditable against future royalty obligations of the
licensee, as well as patent license agreements, are recognized when an arrangement is entered into if we have no significant continuing involvement under the terms of the arrangement. If we have significant continuing involvement under such an
arrangement, license fees are deferred and recognized over the estimated performance period. Management has made estimates and assumptions relating to the performance period, which are subject to change. Changes in these estimates and assumptions
could affect the amount of revenues from licenses reported in any given period.

Stock-Based Compensation

Effective January 1, 2006, we adopted the provisions of, and account for stock-based compensation in accordance with, Statement of
Financial Accounting Standards, or FAS No. 123(R), Share-Based Payment(FAS 123(R) (FASB ASC 718-10). Under the fair value recognition provisions of this statement, stock-based compensation cost is measured at the grant date based on the
fair value of the award and is recognized as expense over the requisite service period, which is the vesting period. We have applied the modified prospective method



33



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of adoption, under which prior periods are not restated for comparative purposes. Under the modified prospective method, FAS 123(R) applies to new awards and to awards that were outstanding as of
December 31, 2005 that are subsequently modified, repurchased or cancelled. Compensation expense recognized during the year ended December 31, 2006 includes expense for all share-based payments granted prior to, but not yet vested as of,
December 31, 2005, based on the grant date fair value estimated in accordance with the provisions of FAS No. 123, Accounting for Stock-Based Compensation, and expense for all share-based payments granted subsequent to
December 31, 2006, based on the grant-date fair value estimated in accordance with the provisions of FAS 123(R). Stock-based compensation is classified within cost of service revenues, research and development, marketing and sales and general
and administrative on the consolidated statement of operations.

Stock options granted to employees, which are granted with an
exercise price equal to or greater than the fair market value of our common stock at the date of grant, in general vest in four years in equal monthly installments and have a maximum term of ten years. Stock options granted to our Board of Directors
in general vest in three years in equal monthly installments and have a maximum term of ten years.

We use the Black-Scholes
option pricing model to estimate the fair value of options granted, which requires the input of highly subjective assumptions. These assumptions include estimating the length of time employees will retain their vested stock options before exercising
them, the estimated volatility of our common stock price over the expected term, the number of options that will ultimately not vest and the expected dividend yield. Changes in the subjective assumptions can materially affect the estimate of the
fair value of stock-based compensation and, consequently, the related amount recognized in the consolidated statements of operations. The expected volatility assumption is based on the daily historical volatility of our stock price, over the
expected term of the option. Our stock options are considered plain vanilla options based on the guidance in SEC Staff Accounting Bulletin, or SAB, No. 107, Share-Based Payment, or SAB 107, as amended by SAB No. 110,
Share-Based Payment, or SAB 110, and as such we have elected to use the simplified method, whereby we have assumed that all options will be exercised midway between the vesting date and the contractual term of the option to
determine the expected term of the option. We will continue to use the simplified method until we have the historical data necessary to provide a reasonable estimate of expected life in accordance with SAB 107, as amended by SAB 110. We have not
paid dividends since our inception, nor do we expect to pay any dividends for the foreseeable future, thus the expected dividend yield assumption is zero. As stock-based compensation expense recognized in the consolidated statement of operations is
based on awards ultimately expected to vest, the amount of expense has been reduced for estimated forfeitures. FAS 123(R) requires forfeitures to be estimated at the time of grant and revised, if necessary, in subsequent periods if actual
forfeitures differ from those estimates. Forfeitures are estimated based on historical experience.

Valuation of Goodwill and Other
Long-lived Assets

Goodwill and other intangible assets acquired in a business combination that are determined to have an
indefinite useful life are not amortized, but instead tested for impairment at least annually in the fourth quarter or between annual tests in the presence of impairment indicators such as:



| |  |  | significant underperformance relative to expected historical or projected future operating results;
| | - |  | ---------------------------------------------------------------------------------------------------



| |  |  | significant changes in the manner of our use of the acquired assets or the strategy for our overall business;
| | - |  | -------------------------------------------------------------------------------------------------------------



| |  |  | significant negative industry or economic trends;
| | - |  | -------------------------------------------------



| |  |  | a significant adverse change in legal factors or in the business climate;
| | - |  | -------------------------------------------------------------------------



| |  |  | a more-likely-than-not expectation of sale or disposal of a reporting unit or a significant portion thereof;
| | - |  | ------------------------------------------------------------------------------------------------------------



| |  |  | significant decrease in the market value of our common stock; and
| | - |  | -----------------------------------------------------------------



| |  |  | a significant decrease in the market value of the assets.
| | - |  | ---------------------------------------------------------

Judgment is required in determining the existence of these factors and its effect on any impairment determination.



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The fair value of our reporting units is determined considering the income, the market or
the transaction valuation approaches or a combination thereof. Under the income approach, the fair value of the reporting unit is based on the present value of the reporting units expected estimated future cash flows. Under the market
approach, the value of the reporting unit is based on an analysis of publicly traded companies in similar lines of business. Under the transaction approach, the value of the reporting unit is based on market transactions of similar businesses.

The process of evaluating the potential impairment of goodwill is subjective and requires significant judgment at many points
during the analysis. In estimating the fair value of our reporting units for the purposes of our annual or interim analyses, we make estimates and judgments about the future cash flows, operating trends, discount rates, and other variables of these
businesses. Although our cash flow forecasts are based on assumptions that are consistent with the plans and estimates we use to manage the underlying businesses, there is significant judgment in determining the cash flows attributable to these
businesses. We also consider our market capitalization on the date we perform the analysis.

Our other long-lived assets
consist primarily of fixed assets and amortizable intangible assets. We review other long-lived assets for impairment whenever events or changes in circumstances indicate that we will not be able to recover the assets carrying amount. Such
events or circumstances include, but are not limited to, a significant decrease in the fair value of the underlying business or asset, a significant decrease in the benefits realized from the acquired business, or a significant change in the
operations of the acquired business or use of an asset.

Recoverability of other long-lived assets is measured by comparison
of the carrying amount of the asset (asset group) to estimated undiscounted cash flows of the asset group. If the carrying amount of an asset group exceeds its estimated future cash flows, an impairment charge is recognized by the amount by which
the carrying amount of the asset exceeds its fair value.

We performed an annual assessment of goodwill as of
December 31, 2010 and concluded that goodwill was not impaired. We performed an impairment assessment of our long-lived assets as of December 31, 2010 and concluded that our long-lived assets were not impaired.

Income Taxes

We have
generated NOL carryforwards for tax purposes since inception. As of December 31, 2010, these NOL carryforwards have resulted in NOL carryforwards of $247.6 million and $36.1 for federal and state income tax purposes, respectively. In addition,
certain charges recorded in the current and prior years were not currently deductible for income tax purposes. These differences result in gross deferred tax assets. We must assess the likelihood that the gross deferred tax assets, net of any
deferred tax liabilities, will be recovered from future taxable income. To the extent we believe the recovery is not likely, we have established a valuation allowance.

Significant management judgment is required in determining this valuation allowance. We have recorded a valuation allowance of $94.0 million as of December 31, 2010, due to uncertainties related to
our ability to utilize some of our net deferred tax assets, primarily consisting of NOL carryforwards, before they expire. The valuation allowance is based on our estimates of taxable income and the period over which the net deferred tax assets will
be recoverable.

Conversely, if we are profitable in the future at levels which cause management to conclude that it is more
likely than not that we will realize all or a portion of the net deferred tax assets for which a valuation has been recorded, we would record the estimated net realizable value of the net deferred tax asset at that time and would then record income
taxes on our US operations at a rate equal to our combined federal and state effective rate of approximately 37%.



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We adopted the provisions of FASB Interpretation No. 48, Accounting for Uncertainty in
Income Taxes (FIN 48), on January 1, 2007. During the year ended December 31, 2010 we decreased our reserve for unrecognized tax benefits by $225 thousand relating to certain allowances and deductions taken on our tax returns since they
were effectively settled in the U.K. The tax year 2009 remains open to examination by the UK taxing authorities and the tax years 2007 to 2009 remain open to examination by the US taxing authorities. In addition, the US taxing authorities may
examine the tax years from 1996 through 2006, but generally are barred from adjusting the tax liabilities in excess of the net operating losses generated in any of those tax years.

Recently Issued Accounting Pronouncements

In January 2010, the FASB
issued Accounting Standard Update No. 2010-06, Improving Disclosures about Fair Value Measurements (ASU No. 2010-06), which amends the existing fair value measurements and disclosures guidance currently included in Accounting
Standards Codification No. 820 to require additional disclosures regarding fair value measurements. Specifically, ASU No. 2010-06 requires entities to disclose the amounts of significant transfers between Level 1 and Level 2 of the fair
value hierarchy and the reasons for these transfers, the reasons for any transfer in or out of Level 3, and information in the reconciliation of recurring Level 3 measurements about purchases, sales, issuance and settlements on a gross basis. In
addition, ASU No. 2010-06 also clarifies the requirement for entities to disclose information about both the valuation techniques and inputs used in estimating Level 2 and Level 3 fair value measurements. ASU No. 2010-06 is effective for
interim and annual reporting periods beginning after December 15, 2009, except for additional disclosures related to Level 3 fair value measurements, which are effective for fiscal years beginning after December 15, 2010. The Company does
not expect these additional disclosure requirements will have a significant impact on its consolidated financial statements.

FORWARD-LOOKING STATEMENTS

This Annual Report on Form 10-K contains forward-looking statements. Such statements are based on managements current expectations and are subject to a number of factors and uncertainties that could
cause actual results or outcomes to differ materially from those described in such forward-looking statements. These statements address or may address the following subjects, among others:



| |  |  | our expectation of the amount and timing of future revenues, expenses and other items affecting the results of our operations;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------



| |  |  | our expectation that, with the increasing availability of non-human genomic data, improved characteristics in livestock or crops will be produced to
protect humans against animal-borne diseases;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our belief that scientists hope to understand and use DNA molecular level knowledge to transform traditional approaches to medicine, agriculture and
other fields;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our expectation that we will incur aggregate restructuring charges and cash expenditures in connection with the consolidation of our East Lansing,
Michigan paternity testing operations into our Dayton, Ohio facility and the consolidation of our Nashville CODIS testing operation into our Dallas, Texas facility of $1.8 million to $2.3 million in the aggregate, which includes: severance and
retention bonuses for employees in the range of $990 thousand to $1.2 million; relocation in the range of $135 thousand to $185 thousand; recruiting and training costs in connection with the transfer of work of approximately $100 thousand; lease
termination costs in the range of $200 thousand to $300 thousand; and equipment relocation and reinstallation costs in the range of $375 thousand to $485 thousand;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our expectation that we will offset the restructuring charges and expenditures in connection with the consolidation of our East Lansing, Michigan
paternity testing operations into our Dayton, Ohio facility and the consolidation of our Nashville CODIS testing operation into our Dallas, Texas facility through annual cost savings of up to approximately $2.4 million from operational efficiencies,
plant and equipment cost reductions and increased scalability;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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| |  |  | our belief that the UK government and police forces will continue to support the use of DNA testing in forensic cases;
| | - |  | ----------------------------------------------------------------------------------------------------------------------



| |  |  | our intention to focus on providing services to a larger segment of UK police forces;
| | - |  | -------------------------------------------------------------------------------------



| |  |  | our belief that DNA testing of non-violent or property crime evidence is a growth area for our forensics business;
| | - |  | ------------------------------------------------------------------------------------------------------------------



| |  |  | our belief that we maintain good relationships with our employees;
| | - |  | ------------------------------------------------------------------



| |  |  | our expectation that the competition for DNA testing services will intensify in the future;
| | - |  | -------------------------------------------------------------------------------------------



| |  |  | our belief that states are in the process of building up their backlogs of DNA samples and that such states will eventually move to administer the
awards in order to reduce such backlog;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our belief that excess CODIS capacity has been built-up in the private sector and this may affect pricing in the future;
| | - |  | ------------------------------------------------------------------------------------------------------------------------



| |  |  | our belief that the consolidations of our forensic and paternity facilities may lead to additional operational efficiencies, plant and equipment cost
reductions and increased scalability;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our belief that our experience and reputation as a reliable provider of services to government agencies is a valued credential that can be used in
securing both new contracts and renewing existing contracts;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our belief that the actions we have taken to date have placed us in a position to successfully transition from our prior reliance on revenues derived
from our subcontracting agreement to directly providing DNA testing services to police forces in the UK;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our expectation that the remaining police forces in the UK will continue to solicit tenders for forensic services through the UKs National
Procurement Plan;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our expectation that our future agricultural testing services revenues will not be significant to our operating results;
| | - |  | ------------------------------------------------------------------------------------------------------------------------



| |  |  | our belief that we are one of the largest providers of forensic and family relationship testing in the UK and the US;
| | - |  | ---------------------------------------------------------------------------------------------------------------------



| |  |  | our belief that the US and UK are some of the largest existing markets for DNA testing services today;
| | - |  | ------------------------------------------------------------------------------------------------------



| |  |  | our intention to evaluate and commercialize new technologies to enhance our laboratory processes, including instrumentation, automation and new testing
methodologies;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our expectation that our instrumentation, automation and new testing methodologies will enable us to reduce our costs for and improve the quality of
our service offerings;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our anticipation that the volume of CODIS testing will grow in the US and that the market for NDNAD work will be relatively stable based on legislation
in the US and the UK;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our anticipation that our current facilities will be sufficient to serve our near term capacity needs;
| | - |  | ------------------------------------------------------------------------------------------------------



| |  |  | our anticipation that federal and state governments in the US will allocate greater resources to support wider use of DNA testing;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------



| |  |  | our intention to seek and continue to seek patent protection for novel uses of SNPs in the genetic testing field;
| | - |  | -----------------------------------------------------------------------------------------------------------------



| |  |  | our intention to continue to concentrate on protection of our intellectual property as it relates to our DNA testing services;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------



| |  |  | our expectation that we will continue to receive substantial discounts based upon reaching a specific threshold of purchases per year of reagents and
other components from our current supplier;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our anticipation that our existing cash on hand will be sufficient to fund our operations at least through the next twelve months;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------



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| |  |  | our anticipation that a portion of our future growth may be accomplished either by acquiring or merging with existing businesses;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------



| |  |  | our plan to continue to market our services to governments, commercial companies and private individuals;
| | - |  | ---------------------------------------------------------------------------------------------------------



| |  |  | our belief that litigation claims arising against us from the normal course of business will not have a material effect on our financial position and
liquidity, but could have a material impact on our results of operations for any reporting period;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our expectation to not pay any dividends in the foreseeable future;
| | - |  | -------------------------------------------------------------------



| |  |  | our intention to retain earnings, if any, to finance our growth;
| | - |  | ----------------------------------------------------------------



| |  |  | our plan to continue to make investments in our business;
| | - |  | ---------------------------------------------------------



| |  |  | our expectation about our significant uses of liquidity;
| | - |  | --------------------------------------------------------



| |  |  | our expectation that the adoption of various recently issued accounting pronouncements will not have a material impact on our consolidated financial
statements;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our belief that the probability of us incurring a material restoration expense upon exiting our operating leases is minimal; and
| | - |  | --------------------------------------------------------------------------------------------------------------------------------



| |  |  | our expectation that our disclosure controls and procedures or our internal control over financial reporting will not prevent all error and all fraud.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------

While management makes its best efforts to be accurate in making forward-looking statements, such
statements are subject to risks and uncertainties that could cause actual results to vary materially, including the risks and uncertainties discussed throughout this Annual Report on Form 10-K and the cautionary information set forth under the
heading Risk Factors appearing in Item 1A of this Annual Report on Form 10-K. We disclaim any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or
otherwise.

Item 7A. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

Interest Rate Sensitivity

Our exposure to market risk is principally confined to our cash equivalents, which are conservative in nature, with a focus on preservation of capital. Due to the short-term nature of our investments and
our investment policies and procedures, we have determined that the risks associated with interest rate fluctuations related to these financial instruments are not material to our business. As of December 31, 2010, we had no short-term or
long-term debt obligations.

Foreign Currency Risk

Our business derives a substantial portion of its revenues from international operations. We record the majority of our foreign operational transactions, including all cash inflows and outflows, in the
local currency, British pound. We record all of our US operational transactions, including cash inflows and outflows, in US dollars. We expect that international sales will continue to represent a significant portion of our revenues. The significant
percentage of our revenues derived from our UK operations makes us vulnerable to future fluctuations in the exchange rate. However, all of our operating expenses related to our UK operations also are subject to exchange rate fluctuations and thus
provide a natural hedge against such exchange rate movements. Currently, there is no material adverse impact to our financial results from exchange rate movements.



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Item 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

ORCHID CELLMARK INC. AND SUBSIDIARIES

Index to Consolidated Financial Statements and Schedule



|                                                                                                                             |  |      |    | 
|---------------------------------------------------------------------------------------------------------------------------- |  | ---- | -- | 
|                                                                                                                             |  | Page |   
|Report of Independent Registered Public Accounting Firm                                                                      |  |      | 40 | 
|                                                                                                                             | 
|Consolidated Financial Statements:                                                                                           |  |      |    | 
|                                                                                                                             | 
|Consolidated Balance Sheets as of December 31, 2010 and 2009                                                                 |  |      | 41 | 
|                                                                                                                             | 
|Consolidated Statements of Operations for the years ended December 31, 2010, 2009 and
2008                                   |  |      | 42 | 
|                                                                                                                             | 
|Consolidated Statements of Stockholders Equity and Comprehensive Loss for the years ended December 31,
 2010, 2009 and 2008 |  |      | 43 | 
|                                                                                                                             | 
|Consolidated Statements of Cash Flows for the years ended December 31, 2010, 2009 and
2008                                   |  |      | 44 | 
|                                                                                                                             | 
|Notes to Consolidated Financial Statements                                                                                   |  |      | 45 | 
|                                                                                                                             | 
|Financial Statement Schedule: Valuation and Qualifying Accounts                                                              |  |      | 72 | 



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REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Board of Directors and Shareholders

Orchid Cellmark Inc.

We have audited the accompanying consolidated balance sheets of Orchid
Cellmark Inc. (a Delaware Corporation) and subsidiaries as of December 31, 2010 and 2009, and the related consolidated statements of operations, stockholders equity and comprehensive loss, and cash flows for each of the three years in the
period ended December 31, 2010. Our audits of the basic financial statements included the financial statement schedule listed in the index appearing under Item 15 (2). These financial statements and financial statement schedule are the
responsibility of the Companys management. Our responsibility is to express an opinion on these financial statements and financial statement schedule based on our audits.

We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable
assurance about whether the financial statements are free of material misstatement. The Company is not required to have, nor were we engaged to perform an audit of its internal control over financial reporting. Our audit included consideration of
internal control over financial reporting as a basis for designing audit procedures that are appropriate in the circumstances, but not for the purpose of expressing an opinion on the effectiveness of the Companys internal control over
financial reporting. Accordingly, we express no such opinion. An audit also includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements, assessing the accounting principles used and significant
estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.

In our opinion, the consolidated financial statements referred to above present fairly, in all material respects, the financial position of Orchid Cellmark Inc. and subsidiaries as of December 31,
2010 and 2009, and the results of their operations and their cash flows for each of the three years in the period ended December 31, 2010 in conformity with accounting principles generally accepted in the United States of America. Also in our
opinion, the related financial statement schedule, when considered in relation to the basic financial statements taken as a whole, presents fairly, in all material respects, the information set forth therein.

/s/ GRANT THORNTON LLP

New York, New York

March 15, 2011



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##### Table of Contents

ORCHID CELLMARK INC. AND SUBSIDIARIES

Consolidated Balance Sheets

December 31, 2010 and 2009

(In thousands, except share and per
share data)



|                                                                                                                                        |  |      |          |   |      |   |          |  
|--------------------------------------------------------------------------------------------------------------------------------------- |  | ---- | -------- | - | ---- | - | -------- | -
|                                                                                                                                        |  | 2010 |          |   | 2009 |  
|Assets                                                                                                                                  |  |      |          |   |      |   |          |  
|Current assets:                                                                                                                         |  |      |          |   |      |   |          |  
|Cash and cash equivalents                                                                                                               |  | $    | 8,107    |   |      | $ | 8,600    |  
|Available-for-sale securities                                                                                                           |  |      | 11,714   |   |      |   | 9,525    |  
|Accounts receivable, net of allowance of $440 and $397 as of December 31, 2010 and 2009, respectively                                   |  |      | 9,781    |   |      |   | 11,128   |  
|Inventory                                                                                                                               |  |      | 1,836    |   |      |   | 1,542    |  
|Prepaids and other current assets                                                                                                       |  |      | 1,213    |   |      |   | 1,127    |  
|                                                                                                                                        |  |      |          |   |      |   |          |  
|Total current assets                                                                                                                    |  |      | 32,651   |   |      |   | 31,922   |  
|Fixed assets, net                                                                                                                       |  |      | 5,791    |   |      |   | 4,803    |  
|Goodwill                                                                                                                                |  |      | 9,396    |   |      |   | 9,423    |  
|Other intangibles, net                                                                                                                  |  |      | 3,901    |   |      |   | 5,763    |  
|Other assets                                                                                                                            |  |      | 774      |   |      |   | 931      |  
|                                                                                                                                        |  |      |          |   |      |   |          |  
|Total assets                                                                                                                            |  | $    | 52,513   |   |      | $ | 52,842   |  
|                                                                                                                                        |  |      |          |   |      |   |          |  
|Liabilities and Stockholders Equity                                                                                                    |  |      |          |   |      |   |          |  
|Current liabilities:                                                                                                                    |  |      |          |   |      |   |          |  
|Accounts payable                                                                                                                        |  | $    | 3,282    |   |      | $ | 2,762    |  
|Accrued expenses and other current liabilities                                                                                          |  |      | 6,198    |   |      |   | 3,071    |  
|Deferred revenue                                                                                                                        |  |      | 1,014    |   |      |   | 928      |  
|                                                                                                                                        |  |      |          |   |      |   |          |  
|Total current liabilities                                                                                                               |  |      | 10,494   |   |      |   | 6,761    |  
|Other liabilities                                                                                                                       |  |      | 216      |   |      |   | 432      |  
|                                                                                                                                        |  |      |          |   |      |   |          |  
|Total liabilities                                                                                                                       |  |      | 10,710   |   |      |   | 7,193    |  
|Commitments and contingencies                                                                                                           |  |      |          |   |      |   |          |  
|Stockholders equity:                                                                                                                   |  |      |          |   |      |   |          |  
|Preferred stock; authorized 5,000,000 shares                                                                                            |  |      |          |   |      |   |          |  
|Series A redeemable convertible preferred stock; $0.001 per share par value; designated 5 shares; no shares issued or
outstanding       |  |      |         |   |      |   |         |  
|Series A junior participating preferred stock; $0.001 per share par value; designated 1,000,000 shares; no shares issued or
outstanding |  |      |         |   |      |   |         |  
|Common stock; $0.001 par value; authorized 150,000,000 shares; issued 30,098,269 at December 31, 2010 and
2009                          |  |      | 30       |   |      |   | 30       |  
|Additional paid-in capital                                                                                                              |  |      | 373,860  |   |      |   | 372,877  |  
|Accumulated other comprehensive income                                                                                                  |  |      | 36       |   |      |   | 343      |  
|Treasury stock at cost, 163,259 common shares at December 31, 2010 and 2009                                                             |  |      | (1,587   | ) |      |   | (1,587   | )
|Accumulated deficit                                                                                                                     |  |      | (330,536 | ) |      |   | (326,014 | )
|                                                                                                                                        |  |      |          |   |      |   |          |  
|Total stockholders equity                                                                                                              |  |      | 41,803   |   |      |   | 45,649   |  
|                                                                                                                                        |  |      |          |   |      |   |          |  
|Total liabilities and stockholders equity                                                                                              |  | $    | 52,513   |   |      | $ | 52,842   |  
|                                                                                                                                        |  |      |          |   |      |   |          |  

See accompanying notes to consolidated financial statements.



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##### Table of Contents

ORCHID CELLMARK INC. AND SUBSIDIARIES

Consolidated Statements of Operations

Years ended December 31, 2010, 2009 and 2008

(In thousands, except
per share data)



|                                                              |  |      |        |   |      |   |        |      |  |   |        |  
|------------------------------------------------------------- |  | ---- | ------ | - | ---- | - | ------ | ---- |  | - | ------ | -
|                                                              |  | 2010 |        |   | 2009 |   |        | 2008 | 
|Revenues:                                                     |  |      |        |   |      |   |        |      |  |   |        |  
|Service revenues                                              |  | $    | 63,694 |   |      | $ | 58,077 |      |  | $ | 57,365 |  
|Other revenues                                                |  |      | 27     |   |      |   | 985    |      |  |   | 230    |  
|                                                              |  |      |        |   |      |   |        |      |  |   |        |  
|Total revenues                                                |  |      | 63,721 |   |      |   | 59,062 |      |  |   | 57,595 |  
|                                                              |  |      |        |   |      |   |        |      |  |   |        |  
|Operating expenses:                                           |  |      |        |   |      |   |        |      |  |   |        |  
|Cost of service revenues                                      |  |      | 41,823 |   |      |   | 38,549 |      |  |   | 40,287 |  
|Research and development                                      |  |      | 1,496  |   |      |   | 834    |      |  |   | 846    |  
|Marketing and sales                                           |  |      | 5,767  |   |      |   | 4,905  |      |  |   | 5,860  |  
|General and administrative                                    |  |      | 14,337 |   |      |   | 14,497 |      |  |   | 16,076 |  
|Restructuring                                                 |  |      | 1,725  |   |      |   | 161    |      |  |   |       |  
|Amortization of intangible assets                             |  |      | 1,849  |   |      |   | 1,860  |      |  |   | 1,895  |  
|                                                              |  |      |        |   |      |   |        |      |  |   |        |  
|Total operating expenses                                      |  |      | 66,997 |   |      |   | 60,806 |      |  |   | 64,964 |  
|                                                              |  |      |        |   |      |   |        |      |  |   |        |  
|Operating loss                                                |  |      | (3,276 | ) |      |   | (1,744 | )    |  |   | (7,369 | )
|Other income:                                                 |  |      |        |   |      |   |        |      |  |   |        |  
|Other income, net                                             |  |      | 189    |   |      |   | 167    |      |  |   | 1,180  |  
|                                                              |  |      |        |   |      |   |        |      |  |   |        |  
|Loss before income taxes                                      |  |      | (3,087 | ) |      |   | (1,577 | )    |  |   | (6,189 | )
|Income tax benefit (expense)                                  |  |      | (1,435 | ) |      |   | 35     |      |  |   | 1,708  |  
|                                                              |  |      |        |   |      |   |        |      |  |   |        |  
|Net loss                                                      |  | $    | (4,522 | ) |      | $ | (1,542 | )    |  | $ | (4,481 | )
|                                                              |  |      |        |   |      |   |        |      |  |   |        |  
|Basic and diluted net loss per share                          |  | $    | (0.15  | ) |      | $ | (0.05  | )    |  | $ | (0.15  | )
|                                                              |  |      |        |   |      |   |        |      |  |   |        |  
|Shares used in computing basic and diluted net loss per share |  |      | 29,935 |   |      |   | 29,935 |      |  |   | 29,935 |  
|                                                              |  |      |        |   |      |   |        |      |  |   |        |  

See accompanying notes to consolidated financial statements.



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ORCHID CELLMARK INC. AND SUBSIDIARIES

Consolidated Statements of Stockholders Equity and Comprehensive Loss

Years ended December 31, 2010, 2009 and 2008

(In thousands)



|                                                           |  |                 |        |  |                          |   |    |                                            |  |   |               |   |  |                    |        |   |                          |   |        |   |  |   |          |   |  |   |        |  
|---------------------------------------------------------- |  | --------------- | ------ |  | ------------------------ | - | -- | ------------------------------------------ |  | - | ------------- | - |  | ------------------ | ------ | - | ------------------------ | - | ------ | - |  | - | -------- | - |  | - | ------ | -
|                                                           |  | Common Stock    |        |  | AdditionalPaid-inCapital |   |    | AccumulatedOtherComprehensiveIncome (Loss) |  |   | TreasuryStock |   |  | AccumulatedDeficit |        |   | TotalStockholdersEquity |  
|                                                           |  | Number ofShares |        |  | Amount                   |   |    |                                            |  |   |              
|Balance at January 1, 2008                                 |  |                 | 30,097 |  |                          | $ | 30 |                                            |  | $ | 370,129       |   |  | $                  | 3,852  |   |                          | $ | (1,587 | ) |  | $ | (319,991 | ) |  | $ | 52,433 |  
|Net loss                                                   |  |                 |       |  |                          |   |   |                                            |  |   |              |   |  |                    |       |   |                          |   |       |   |  |   | (4,481   | ) |  |   | (4,481 | )
|Foreign currency translation adjustment                    |  |                 |       |  |                          |   |   |                                            |  |   |              |   |  |                    | (4,832 | ) |                          |   |       |   |  |   |         |   |  |   | (4,832 | )
|Comprehensive loss                                         |  |                 |        |  |                          |   |    |                                            |  |   |               |   |  |                    |        |   |                          |   |        |   |  |   |          |   |  |   | (9,313 | )
|Issuance of common stock from exercise of stock options    |  |                 | 1      |  |                          |   |   |                                            |  |   | 2             |   |  |                    |       |   |                          |   |       |   |  |   |         |   |  |   | 2      |  
|Stock-based compensation expense                           |  |                 |       |  |                          |   |   |                                            |  |   | 1,246         |   |  |                    |       |   |                          |   |       |   |  |   |         |   |  |   | 1,246  |  
|Balance at December 31, 2008                               |  |                 | 30,098 |  |                          | $ | 30 |                                            |  | $ | 371,377       |   |  | $                  | (980   | ) |                          | $ | (1,587 | ) |  | $ | (324,472 | ) |  | $ | 44,368 |  
|                                                           |  |                 |        |  |                          |   |    |                                            |  |   |               |   |  |                    |        |   |                          |   |        |   |  |   |          |   |  |   |        |  
|Net loss                                                   |  |                 |       |  |                          |   |   |                                            |  |   |              |   |  |                    |       |   |                          |   |       |   |  |   | (1,542   | ) |  |   | (1,542 | )
|Foreign currency translation adjustment                    |  |                 |       |  |                          |   |   |                                            |  |   |              |   |  |                    | 1,306  |   |                          |   |       |   |  |   |         |   |  |   | 1,306  |  
|Unrealized gains (losses) on available-for-sale securities |  |                 |        |  |                          |   |    |                                            |  |   |               |   |  |                    | 17     |   |                          |   |        |   |  |   |          |   |  |   | 17     |  
|                                                           |  |                 |        |  |                          |   |    |                                            |  |   |               |   |  |                    |        |   |                          |   |        |   |  |   |          |   |  |   |        |  
|Comprehensive loss                                         |  |                 |        |  |                          |   |    |                                            |  |   |               |   |  |                    |        |   |                          |   |        |   |  |   |          |   |  |   | (219   | )
|                                                           |  |                 |        |  |                          |   |    |                                            |  |   |               |   |  |                    |        |   |                          |   |        |   |  |   |          |   |  |   |        |  
|Stock-based compensation expense                           |  |                 |       |  |                          |   |   |                                            |  |   | 1,500         |   |  |                    |       |   |                          |   |       |   |  |   |         |   |  |   | 1,500  |  
|Balance at December 31, 2009                               |  |                 | 30,098 |  |                          | $ | 30 |                                            |  | $ | 372,877       |   |  | $                  | 343    |   |                          | $ | (1,587 | ) |  | $ | (326,014 | ) |  | $ | 45,649 |  
|                                                           |  |                 |        |  |                          |   |    |                                            |  |   |               |   |  |                    |        |   |                          |   |        |   |  |   |          |   |  |   |        |  
|Net loss                                                   |  |                 |       |  |                          |   |   |                                            |  |   |              |   |  |                    |       |   |                          |   |       |   |  |   | (4,522   | ) |  |   | (4,522 | )
|Gain/loss on available for sale securities                 |  |                 |       |  |                          |   |   |                                            |  |   |              |   |  |                    | (28    | ) |                          |   |       |   |  |   |         |   |  |   | (28    | )
|Foreign currency translation adjustment                    |  |                 |       |  |                          |   |   |                                            |  |   | (4            | ) |  |                    | (279   | ) |                          |   |       |   |  |   |         |   |  |   | (283   | )
|                                                           |  |                 |        |  |                          |   |    |                                            |  |   |               |   |  |                    |        |   |                          |   |        |   |  |   |          |   |  |   |        |  
|Comprehensive loss                                         |  |                 |        |  |                          |   |    |                                            |  |   |               |   |  |                    |        |   |                          |   |        |   |  |   |          |   |  |   | (4,833 | )
|                                                           |  |                 |        |  |                          |   |    |                                            |  |   |               |   |  |                    |        |   |                          |   |        |   |  |   |          |   |  |   |        |  
|Stock-based compensation expense                           |  |                 |       |  |                          |   |   |                                            |  |   | 987           |   |  |                    |       |   |                          |   |       |   |  |   |         |   |  |   | 987    |  
|                                                           |  |                 |        |  |                          |   |    |                                            |  |   |               |   |  |                    |        |   |                          |   |        |   |  |   |          |   |  |   |        |  
|Balance at December 31, 2010                               |  |                 | 30,098 |  |                          | $ | 30 |                                            |  | $ | 373,860       |   |  | $                  | 36     |   |                          | $ | (1,587 | ) |  | $ | (330,536 | ) |  | $ | 41,803 |  
|                                                           |  |                 |        |  |                          |   |    |                                            |  |   |               |   |  |                    |        |   |                          |   |        |   |  |   |          |   |  |   |        |  

See accompanying notes to consolidated financial statements.



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ORCHID CELLMARK INC. AND SUBSIDIARIES

Consolidated Statements of Cash Flows

Years ended December 31, 2010, 2009 and 2008

(In thousands)



|                                                                                          |  |      |        |   |      |   |         |      |  |   |        |  
|----------------------------------------------------------------------------------------- |  | ---- | ------ | - | ---- | - | ------- | ---- |  | - | ------ | -
|                                                                                          |  | 2010 |        |   | 2009 |   |         | 2008 | 
|Cash flows from operating activities:                                                     |  |      |        |   |      |   |         |      |  |   |        |  
|Net loss                                                                                  |  | $    | (4,522 | ) |      | $ | (1,542  | )    |  | $ | (4,481 | )
|Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |      |        |   |      |   |         |      |  |   |        |  
|Stock-based compensation expense                                                          |  |      | 987    |   |      |   | 1,500   |      |  |   | 1,246  |  
|Depreciation and amortization                                                             |  |      | 3,680  |   |      |   | 3,908   |      |  |   | 4,477  |  
|Provision for losses on accounts receivable                                               |  |      | 165    |   |      |   | 188     |      |  |   | (36    | )
|Loss on sale of assets                                                                    |  |      | 23     |   |      |   | 40      |      |  |   | 8      |  
|Changes in assets and liabilities, net of effect of acquisition:                          |  |      |        |   |      |   |         |      |  |   |        |  
|Accounts receivable                                                                       |  |      | 1,235  |   |      |   | (1,198  | )    |  |   | (1,905 | )
|Inventory                                                                                 |  |      | (294   | ) |      |   | (281    | )    |  |   | (88    | )
|Prepaids and other current assets                                                         |  |      | (85    | ) |      |   | 265     |      |  |   | 698    |  
|Other assets                                                                              |  |      | 157    |   |      |   | (491    | )    |  |   | 11     |  
|Accounts payable                                                                          |  |      | 519    |   |      |   | 218     |      |  |   | 945    |  
|Accrued expenses and other current liabilities, including restructuring                   |  |      | 2,138  |   |      |   | 575     |      |  |   | (2,080 | )
|Deferred revenue                                                                          |  |      | 86     |   |      |   | 86      |      |  |   | (184   | )
|Income taxes payable                                                                      |  |      | 989    |   |      |   | 208     |      |  |   | (425   | )
|Other liabilities                                                                         |  |      | (216   | ) |      |   | 163     |      |  |   | (517   | )
|                                                                                          |  |      |        |   |      |   |         |      |  |   |        |  
|Net cash provided by (used in) operating activities                                       |  |      | 4,862  |   |      |   | 3,639   |      |  |   | (2,331 | )
|                                                                                          |  |      |        |   |      |   |         |      |  |   |        |  
|Cash flows from investing activities:                                                     |  |      |        |   |      |   |         |      |  |   |        |  
|Purchases of available-for-sale securities                                                |  |      | (9,298 | ) |      |   | (9,627  | )    |  |   |       |  
|Maturities of available-for-sale securities                                               |  |      | 5,873  |   |      |   |        |      |  |   | (2,121 | )
|Capital expenditures                                                                      |  |      | (2,889 | ) |      |   | (793    | )    |  |   | (2,121 | )
|Decrease in restricted cash                                                               |  |      |       |   |      |   |        |      |  |   | 958    |  
|                                                                                          |  |      |        |   |      |   |         |      |  |   |        |  
|Net cash used in investing activities                                                     |  |      | (6,314 | ) |      |   | (10,420 | )    |  |   | (1,163 | )
|                                                                                          |  |      |        |   |      |   |         |      |  |   |        |  
|Cash flows from financing activities:                                                     |  |      |        |   |      |   |         |      |  |   |        |  
|Proceeds from issuance of common stock                                                    |  |      |       |   |      |   |        |      |  |   | 2      |  
|Repayment of debt                                                                         |  |      |       |   |      |   | (338    | )    |  |   | (427   | )
|                                                                                          |  |      |        |   |      |   |         |      |  |   |        |  
|Net cash used in financing activities                                                     |  |      |       |   |      |   | (338    | )    |  |   | (425   | )
|                                                                                          |  |      |        |   |      |   |         |      |  |   |        |  
|Effect of foreign currency translation on cash and cash equivalents                       |  |      | 959    |   |      |   | 721     |      |  |   | (2,001 | )
|                                                                                          |  |      |        |   |      |   |         |      |  |   |        |  
|Net decrease in cash and cash equivalents                                                 |  |      | (493   | ) |      |   | (6,398  | )    |  |   | (5,920 | )
|Cash and cash equivalents at beginning of year                                            |  |      | 8,600  |   |      |   | 14,998  |      |  |   | 20,918 |  
|                                                                                          |  |      |        |   |      |   |         |      |  |   |        |  
|Cash and cash equivalents at end of year                                                  |  | $    | 8,107  |   |      | $ | 8,600   |      |  | $ | 14,998 |  
|                                                                                          |  |      |        |   |      |   |         |      |  |   |        |  
|Supplemental disclosure of cash flow information:                                         |  |      |        |   |      |   |         |      |  |   |        |  
|Cash paid during the year for interest                                                    |  | $    |       |   |      | $ | 2       |      |  | $ | 38     |  
|Cash paid during the year for taxes                                                       |  |      | 645    |   |      |   | 84      |      |  |   | 836    |  

See accompanying notes
to consolidated financial statements.



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ORCHID CELLMARK INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(1) Summary of Significant Accounting Policies

Organization and
Business Activities

Orchid Cellmark Inc. and its subsidiaries (the Company) are engaged in the provision
of DNA testing services that generate genetic profile information by analyzing an organisms unique genetic identity. The Company focuses its business on DNA testing primarily for human identity and, to a lesser extent, agricultural
applications. In the human identity area, the Company provides DNA testing services for forensic, family relationship and, to a lesser extent, security applications. Forensic DNA testing is primarily used to confirm that a suspect committed a
particular crime, to exonerate an innocent person or to establish or maintain databases of individuals convicted of crimes or, in some instances, arrested in connection with crimes. The Company is also engaged in the provision of non-DNA forensic
laboratory services. Family relationship DNA testing is used to establish whether two or more people are genetically related. DNA testing is used by individuals and employers in security applications to establish or store a persons genetic
profile for identification purposes in the event of an emergency or accident. In agricultural applications, the Company provides DNA testing services for selective trait breeding. The Company has operations in the United States (US), and in the
United Kingdom (UK), and the majority of its current customers are based in these two countries. The Companys forensic, family relationship and security DNA testing services are conducted in both the US and the UK, while all of its
agricultural DNA testing services are conducted in the UK. The Company was organized under the laws of the state of Delaware on March 8, 1995.

Consolidated Financial Statements

The accompanying consolidated
financial statements include the results of operations of the Company and its wholly owned subsidiaries. All intercompany accounts and transactions have been eliminated in consolidation.

Cash and Cash Equivalents

The Company considers all highly liquid investments with a maturity of three months or less when purchased to be cash equivalents.

Marketable Securities

The Company has investments in marketable
securities that are considered available-for-sale. Available-for-sale securities are required to be carried at their fair value, with unrealized gains and losses (net of income taxes) that are considered temporary in nature recorded in
Accumulated other comprehensive income in the accompanying consolidated balance sheets. The Company periodically evaluates its investments in marketable securities for impairment due to declines in market value considered to be other
than temporary. Such impairment evaluations include, in addition to persistent, declining market prices, general economic and Company-specific evaluations. If the Company determines that a decline in market value is other than temporary, then a
charge to operations is recorded in Other income, net in the accompanying consolidated statements of operations and a new cost basis in the investment is established.

Fair Value Measurements and Marketable Securities

Fair value of financial and non-financial assets and liabilities is defined as an exit price, which is the price that would be received to sell an asset or paid to transfer a liability in an orderly
transaction between market participants at the measurement date. The three-tier hierarchy for inputs used to measure fair value, which prioritizes the inputs to valuation techniques used to measure fair value, is as follows:

Level 1  quoted prices (unadjusted) in active markets for identical assets or liabilities.



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ORCHID CELLMARK INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



Level 2  quoted prices for similar assets and liabilities in active markets or inputs that are
observable for the asset or liability, either directly or indirectly through market corroboration, for substantially the full term of the financial instrument.

Level 3  unobservable inputs based on the Companys assumptions used to measure assets and liabilities at fair value.

A financial asset or liabilitys classification within the hierarchy is determined based on the lowest level input that is significant to the fair value measurement. The assessment of the
significance of a particular input to the fair value measurement requires judgment, and may affect the valuation of the assets and liabilities being measured and their placement within the fair value hierarchy.

Concentration of Credit Risk

Financial instruments which potentially subject the Company to concentrations of credit risk consist principally of cash, cash equivalents, available-for-sale securities, and accounts receivable. The
Company maintains cash investments primarily in money market securities, U.S. Treasury and government agency securities. The Company maintains its holdings in cash in excess of federally insured amounts and in cash equivalents with high
credit-quality financial institutions in order to minimize credit risk exposure.

Concentrations of credit risk with respect
to accounts receivable are limited due to the large number of customers and the fact that the Companys accounts receivable is largely comprised of amounts owed by government agencies, one of which accounted for approximately 25% of the
Companys total revenues in the year ended December 31, 2010 . The Company performs periodic credit evaluation of its customers financial condition and generally does not require a deposit from government agencies or private
institutions. The Company believes that individual private customers for paternity testing represent the most significant credit risk and generally requires a deposit for all or a portion of the services to be rendered to such customer. The Company
records an allowance for doubtful accounts, reducing the receivables balance to an amount it estimates is collectible from its customers. Estimates used in determining the allowance for doubtful accounts are based on historical collection
experience, current trends, aging of accounts receivable, and periodic credit evaluations of the Companys customers financial condition. When aware of a specific customers inability to meet its financial obligations, such as in the
case of bankruptcy filings or deterioration in the customers operating results or financial position, the Company records a specific reserve for bad debt to reduce the related receivable to the amount the Company reasonably believes is
collectible. Accounts are also reviewed for potential write-off on a case by case basis. Accounts deemed uncollectible are written off, net of expected recoveries. If circumstances related to specific customers change, the Companys estimates
of the recoverability of receivables could be further adjusted.

Inventory

Inventory is stated at the lower of cost or market. Cost is determined by the first-in, first-out method.

Fixed Assets

Fixed assets, which consist of lab equipment, furniture and fixtures, computers and software, are carried at cost, less accumulated depreciation, which is computed on the straight-line basis over the
estimated useful lives of the related assets. Leasehold improvements, which are also included in fixed assets, are recorded at cost, less accumulated depreciation, which is computed on the straight-line basis over the shorter of their estimated
useful



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ORCHID CELLMARK INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



lives or the lease term. Expenditures for maintenance and repairs are charged to expense as incurred. Upon retirement or other disposition of fixed assets, the cost andrelated accumulated
depreciation are removed from the accounts and the resulting gains or losses, if any, are reflected in earnings.

The
following is a summary of the estimated useful lives of the Companys fixed assets:



|                       |  |                                       
|---------------------- |  | --------------------------------------
|                       |  | Useful Life                           
|Laboratory equipment   |  | 5 years                               
|Computers and software |  | 3 years                               
|Furniture and fixtures |  | 7 years                               
|Leasehold improvements |  | Life of lease or usefullife if shorter

Business Combinations, Goodwill and Intangible Assets

The Company
accounts for business combinations under the provisions of Statement of Financial Accounting Standards (ASC 805-10), Business Combinations, which requires that the purchase method of accounting be used for all business combinations. ASC
805-10 also specifies criteria intangible assets acquired in a purchase method business combination must meet to be recognized and reported apart from goodwill. Goodwill represents the excess purchase price over the fair value of the tangible
net assets and intangible assets acquired in a business combination. In accordance with ASC 350-10, Goodwill and Other Intangible Assets(ASC 350-10), goodwill and intangible assets with indefinite useful lives are not amortized, but instead
tested for impairment annually, or more frequently as needed when events or changes have occurred that would suggest an impairment of the asset. Impairment of goodwill is assessed by determining whether the fair values of the applicable reporting
units exceed their carrying values. The evaluation of fair value requires the use of projections, estimates and assumptions as to the future performance of the operations in performing a discounted cash flow analysis, as well as assumptions
regarding sales and earnings multiples that would be applied in comparable acquisitions. Intangible assets acquired as a result of a business combination are recorded at their fair value at the acquisition date. Intangible assets acquired
individually are recorded at their acquisition cost. Definite lived intangible assets are amortized on a straight-line basis over their estimated useful lives.

Impairment of Long-Lived Assets and Long-Lived Assets to Be Disposed Of

In accordance with ASC 360-10,Accounting for the Impairment or Disposal of Long-Lived Assets, the Company reviews long-lived assets and intangible assets for impairment whenever events or changes
in circumstances indicate that the carrying amount of an asset may not be recoverable. Recoverability of assets to be held and used is measured by a comparison of the carrying amount of an asset to the undiscounted future net cash flows expected to
be generated by the asset. If such assets are considered to be impaired, the impairment to be recognized is measured by the amount by which the carrying amount of the assets exceeds the fair value of the assets. Assets to be disposed of are reported
at the lower of the carrying amount or fair value less costs to dispose.

Income Taxes

The Company accounts for income taxes in accordance with the asset and liability method prescribed by ASC 740,Accounting for Income
Taxes. Under this method, deferred tax assets and liabilities are determined based on the difference between the financial statement and tax basis of assets and liabilities, and net operating loss (NOL) and credit carryforwards. Deferred tax
assets and liabilities are measured using tax rates in effect for



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ORCHID CELLMARK INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



the years in which the items are expected to reverse. The measurement of deferred tax assets is reduced, if necessary, by a valuation allowance for any tax benefits which are not expected to be
realized. The effect on deferred tax assets and liabilities of a change in tax rates is recognized in the period that such tax rate changes are enacted. In certain situations, a taxing authority may challenge positions that the Company has adopted
in the income tax filings. Accordingly, the Company may apply different tax treatment for these selected transactions in filing its tax return than for financial reporting purposes. The Company regularly assesses its uncertain tax position and
records a liability if appropriate. The liability is utilized or reversed once the statute of limitations has expired or the matter is otherwise resolved.

Revenue Recognition

The Company recognizes DNA laboratory services
revenues at the time test results are completed and reported if persuasive evidence of an arrangement exists, the price to the buyer is fixed or determinable and collectibility is reasonably assured. Deferred revenues represent the unearned portion
of payments received in advance of tests being completed and reported. Unbilled receivables represent revenue which has been earned on completed and reported tests, but has not been billed to the customer. Revenues from license arrangements,
including license fees creditable against future royalty obligations of the licensee, are recognized when an arrangement is entered into if the Company has no significant continuing involvement under the terms of the arrangement. If the Company has
significant continuing involvement under such an arrangement, license fees are deferred and recognized over the estimated performance period. Management has made estimates and assumptions relating to the performance period, which are subject to
change. Changes in these estimates and assumptions could affect the amount of revenues from licenses reported in any given period.

Research and Development

Costs incurred for research and product
development, including salaries and related personnel costs, fees paid to consultants and outside service providers, and material costs for prototypes and test units, are expensed as incurred. The Company recognizes research and development expenses
in the period incurred and in accordance with the specific contractual performance terms of such research agreements. Costs incurred in obtaining technology licenses and development of software is charged to research and development expense if the
technology licensed or the software being developed has not reached technological feasibility.

Use of Estimates

The preparation of consolidated financial statements in conformity with US generally accepted accounting principles
(GAAP) requires the Company to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities as of the date of the consolidated financial statements and the reported
amounts of revenues and expenses during the reporting period. The Company bases its estimates on historical experience and on other assumptions that it believes to be relevant under the circumstances, the results of which form the basis for making
judgments about the carrying value of assets and liabilities that are not readily apparent from other sources. In particular, judgment is used in areas such as the allowance for doubtful accounts, impairment of long-lived assets and goodwill, useful
lives of assets, accrual of bonuses, stock-based compensation and income taxes. Actual results could differ from these estimates.

Financial Instruments

The carrying amounts of cash and cash
equivalents, accounts receivable and accounts payable approximate their fair values because of the short maturity of these instruments. The carrying amount of available for sale securities approximate their fair value based on quoted market prices
as of December 31, 2010.



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Translation of Foreign Currencies.

All assets and liabilities of foreign subsidiaries are translated into dollars at the fiscal year-end (current) exchange rates, and
revenue and expense are translated at average rates for the fiscal year. The resulting translation adjustments are included in shareholders equity. Gains and losses on foreign currency exchange transactions are reflected in the statement of
operations. Net transaction gains and losses credited or charged to Other income, net for the fiscal years ended December 31, 2010, 2009 and 2008 were $34 thousand, $(11) thousand and $(378) thousand, respectively.

Net Loss Per Share

Net loss per share is computed in accordance with ASC 260-10, Earnings Per Shareby dividing the net loss allocable to common stockholders by the weighted average number of shares of common stock
outstanding. The Company has certain options which have not been used in the calculation of diluted net loss per share allocable to common stockholders because to do so would be anti-dilutive. As such, the numerator and the denominator used in
computing both basic and diluted net loss per share allocable to common stockholders for each year presented are equal.

Advertising

The Company expenses all advertising costs as incurred.

Sales and Value
Added Taxes

Sales and value added (VAT) taxes collected from customers are excluded from revenues. The obligation is
included in accrued liabilities until the taxes are remitted to the appropriate taxing authorities.

Recent Accounting
Pronouncements

In January 2010, the FASB issued Accounting Standard Update No. 2010-06, Improving Disclosures
about Fair Value Measurements (ASU No. 2010-06), which amends the existing fair value measurements and disclosures guidance currently included in Accounting Standards Codification No. 820 to require additional disclosures
regarding fair value measurements. Specifically, ASU No. 2010-06 requires entities to disclose the amounts of significant transfers between Level 1 and Level 2 of the fair value hierarchy and the reasons for these transfers, the reasons for any
transfer in or out of Level 3, and information in the reconciliation of recurring Level 3 measurements about purchases, sales, issuance and settlements on a gross basis. In addition, ASU No. 2010-06 also clarifies the requirement for entities
to disclose information about both the valuation techniques and inputs used in estimating Level 2 and Level 3 fair value measurements. ASU No. 2010-06 is effective for interim and annual reporting periods beginning after December 15, 2009,
except for additional disclosures related to Level 3 fair value measurements, which are effective for fiscal years beginning after December 15, 2010. The Company does not expect these additional disclosure requirements will have a significant
impact on its consolidated financial statements.

(2) Stock-based Compensation

During 1995, the Company established the 1995 Stock Incentive Plan (the 1995 Plan), which provided for the granting of restricted common
stock or incentive and nonqualified stock options to the Companys directors, employees and consultants. An aggregate of 700,000 shares of the Companys common stock was authorized for issuance under the 1995 Plan, which expired by its
terms on November 28, 2005.



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During 2000, the Board of Directors and stockholders of the Company approved the 2000
Employee, Director and Consultant Stock Incentive Plan (the 2000 Plan) for the issuance of common stock, incentive stock options and nonqualified stock options to the Companys employees, directors and consultants. The Company was originally
authorized to issue options for up to 900,000 shares of the Companys common stock under the 2000 Plan. On June 8, 2005, at the Companys Annual Meeting of Stockholders, the stockholders approved the Companys Amended and
Restated 2005 Stock Plan (the 2005 Plan). The 2005 Plan amended and restated in its entirety the 2000 Plan. The 2005 Plan authorizes the grant of up to approximately 1,700,000 shares plus the number of additional shares as described in the 2005
Plan, for the issuance of incentive stock options, nonqualified stock options, stock grants and other stock-based awards to the Companys employees, directors and consultants. On June 21, 2007, at the Companys Annual Meeting of
Stockholders, the stockholders approved an amendment to the 2005 Plan to increase the aggregate number of shares available for issuance under the 2005 Plan by 2,000,000 shares. The 2005 Plan also specifies other terms such as eligibility, annual
limits and the grant of awards thereunder. The 1995 Plan and the 2005 Plan provide that in the event of a change in control in the beneficial ownership of the Company, as defined therein, all options may, at the discretion of the compensation
committee of the Companys Board of Directors, become fully vested and exercisable immediately prior to the change in control.

Stock options granted under the 2005 Plan are granted at a price equal to or greater than the fair market value of the Companys common stock at the date of grant. Stock options granted to employees
in general vest over four years in equal monthly installments and have a maximum term of ten years. Stock options granted to the Companys Board of Directors in general vest over three years in equal monthly installments and have a maximum term
of ten years. The Company issues new shares of its common stock upon exercise of stock options.

The Company uses the
Black-Scholes option pricing model to estimate the fair value of options granted, which requires the input of highly subjective assumptions. The Companys assumptions used in recognizing compensation expense in the consolidated statement
of operations include estimating the length of time employees will retain their vested stock options before exercising them, the estimated volatility of the Companys common stock price over the expected term and the number of options that will
ultimately not vest. Changes in the subjective assumptions can materially affect the estimate of the fair value of stock-based compensation and, consequently, the related amount of compensation expense recognized in the consolidated statement of
operations.

The following weighted average assumptions were used in valuing the options granted during the years ended
December 31, 2010, 2009 and 2008:



|                        |  |      |         |   |      |  |         |      |  |  |         |  
|----------------------- |  | ---- | ------- | - | ---- |  | ------- | ---- |  |  | ------- | -
|                        |  | 2010 |         |   | 2009 |  |         | 2008 | 
|Risk-free interest rate |  |      | 2.22    | % |      |  | 3.39    | %    |  |  | 3.46    | %
|Volatility              |  |      | 75      | % |      |  | 75      | %    |  |  | 80      | %
|Expected option term    |  |      | 6 years |   |      |  | 6 years |      |  |  | 6 years |  
|Expected dividend yield |  |      | 0       | % |      |  | 0       | %    |  |  | 0       | %

The risk-free interest
rate assumption is based upon the US Treasury yields in effect at the time of grant for a term that approximates the expected term of the option. The expected volatility assumption is based on the daily historical volatility of the Companys
stock price over the expected term of the option. The Companys stock options are considered plain vanilla options based on the guidance in SEC Staff Accounting Bulletin (SAB) No. 107, Share-Based Payment(SAB 107), as
amended by SAB No. 110, Share-Based Payment (SAB 110), and as such the Company has elected the use of the simplified method, whereby the Company has



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assumed that all options will be exercised midway between the vesting date and the contractual term of the option to determine the expected term of the option The Company will continue to use the
simplified method until it has the historical data necessary to provide a reasonable estimate of expected life, in accordance with SAB 107, as amended by SAB 110. As the Company has not paid dividends since inception, nor does it expect to pay any
dividends for the foreseeable future, the expected dividend yield assumption is zero.

Net loss for the years ended
December 31, 2010, 2009 and 2008 includes $987 thousand, $1.5 million and $1.2 million, respectively, of compensation costs related to stock-based compensation arrangements. The Company did not capitalize any of the compensation costs for the
years ended December 31, 2010, 2009 and 2008 in fixed assets, inventory or other assets. The Company has not benefited from a tax deduction for stock option exercises due to net losses for the periods during which the options were
exercised.

Information with respect to outstanding options under the plans at December 2008, 2009 and 2010 and changes during
the years presented is as follows:



|                                         |  |        |           |   |                                |   |       |                                            |  |  |                         |  |  |   |        | 
|---------------------------------------- |  | ------ | --------- | - | ------------------------------ | - | ----- | ------------------------------------------ |  |  | ----------------------- |  |  | - | ------ | 
|                                         |  | Shares |           |   | Weighted averageexercise price |   |       | Weighted 
averageremainingcontractual term |  |  | Aggregateintrinsicvalue | 
|Options outstanding at January 1, 2008   |  |        | 1,653,925 |   |                                | $ | 8.13  |                                            |  |  |                         |  |  |   |        | 
|Granted                                  |  |        | 614,468   |   |                                |   | 3.05  |                                            |  |  |                         |  |  |   |        | 
|Exercised                                |  |        | (875      | ) |                                |   | 2.18  |                                            |  |  |                         |  |  |   |        | 
|Forfeited                                |  |        | (56,026   | ) |                                |   | 4.52  |                                            |  |  |                         |  |  |   |        | 
|Expired                                  |  |        | (48,688   | ) |                                |   | 7.78  |                                            |  |  |                         |  |  |   |        | 
|                                         |  |        |           |   |                                |   |       |                                            |  |  |                         |  |  |   |        | 
|Options outstanding at December 31, 2008 |  |        | 2,162,804 |   |                                | $ | 6.79  |                                            |  |  | 7.35                    |  |  | $ | 0      | 
|                                         |  |        |           |   |                                |   |       |                                            |  |  |                         |  |  |   |        | 
|                                         |  |        |           |  
|                                         |  | Shares |           |   | Weighted averageexercise price |   |       | Weighted 
averageremainingcontractual term |  |  | Aggregateintrinsicvalue | 
|Options outstanding at January 1, 2009   |  |        | 2,162,804 |   |                                | $ | 6.79  |                                            |  |  |                         |  |  |   |        | 
|Granted                                  |  |        | 690,313   |   |                                |   | 1.58  |                                            |  |  |                         |  |  |   |        | 
|Exercised                                |  |        |          |   |                                |   |      |                                            |  |  |                         |  |  |   |        | 
|Cancelled                                |  |        | (295,893  | ) |                                |   | 10.49 |                                            |  |  |                         |  |  |   |        | 
|                                         |  |        |           |   |                                |   |       |                                            |  |  |                         |  |  |   |        | 
|Options outstanding at December 31, 2009 |  |        | 2,557,225 |   |                                | $ | 4.95  |                                            |  |  | 7.42                    |  |  | $ | 83,300 | 
|                                         |  |        |           |   |                                |   |       |                                            |  |  |                         |  |  |   |        | 
|Options exercisable at December 31, 2009 |  |        | 1,622,977 |   |                                | $ | 6.26  |                                            |  |  | 6.56                    |  |  | $ | 29,856 | 
|                                         |  |        |           |   |                                |   |       |                                            |  |  |                         |  |  |   |        | 
|                                         |  |        |           |  
|                                         |  | Shares |           |   | Weighted averageexercise price |   |       | Weighted 
averageremainingcontractual term |  |  | Aggregateintrinsicvalue | 
|Options outstanding at January 1, 2010   |  |        | 2,557,225 |   |                                | $ | 4.95  |                                            |  |  |                         |  |  |   |        | 
|Granted                                  |  |        | 691,478   |   |                                |   | 1.68  |                                            |  |  |                         |  |  |   |        | 
|Exercised                                |  |        |          |   |                                |   |      |                                            |  |  |                         |  |  |   |        | 
|Cancelled                                |  |        | (154,198  | ) |                                |   | 17.43 |                                            |  |  |                         |  |  |   |        | 
|                                         |  |        |           |   |                                |   |       |                                            |  |  |                         |  |  |   |        | 
|Options outstanding at December 31, 2010 |  |        | 3,094,505 |   |                                | $ | 3.60  |                                            |  |  | 6.41                    |  |  | $ | 29,400 | 
|                                         |  |        |           |   |                                |   |       |                                            |  |  |                         |  |  |   |        | 
|Options exercisable at December 31, 2010 |  |        | 2,190,308 |   |                                | $ | 4.22  |                                            |  |  | 5.44                    |  |  | $ | 22,463 | 
|                                         |  |        |           |   |                                |   |       |                                            |  |  |                         |  |  |   |        | 



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Additional information about the Companys share-based payments is as follows (in
thousands, except per share data):



|                                                                    |  |                         |      |  |      |   |      |      |  |   |      | 
|------------------------------------------------------------------- |  | ----------------------- | ---- |  | ---- | - | ---- | ---- |  | - | ---- | 
|                                                                    |  | Year ended December 31, |     
|                                                                    |  | 2010                    |      |  | 2009 |   |      | 2008 | 
|Total intrinsic value of options exercised                          |  | $                       |     |  |      | $ |     |      |  | $ | 2    | 
|Net cash proceeds from the exercise of stock options                |  |                         |     |  |      |   |     |      |  |   | 2    | 
|Weighted average grant date fair value per share of options granted |  |                         | 1.12 |  |      |   | 1.08 |      |  |   | 2.15 | 

As of
December 31, 2010, there was $1.2 million of unrecognized compensation cost related to stock options, which is expected to be recognized over a weighted average period of 2.67 years.

(3) Fair Value Measurements and Marketable Securities

Fair value of
financial and non-financial assets and liabilities is defined as an exit price, which is the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date.
The three-tier hierarchy for inputs used to measure fair value, which prioritizes the inputs to valuation techniques used to measure fair value, is as follows:

Level 1  quoted prices (unadjusted) in active markets for identical assets or liabilities.

Level 2  quoted prices for similar assets and liabilities in active markets or inputs that are observable for the asset or liability, either
directly or indirectly through market corroboration, for substantially the full term of the financial instrument.

Level 3  unobservable
inputs based on the Companys assumptions used to measure assets and liabilities at fair value.

A financial asset or
liabilitys classification within the hierarchy is determined based on the lowest level input that is significant to the fair value measurement. The assessment of the significance of a particular input to the fair value measurement requires
judgment, and may affect the valuation of the assets and liabilities being measured and their placement within the fair value hierarchy.

The following is a schedule of marketable securities (in thousands):



|                              |  |              |        |  |                                         |   |        |                                  |  |   |                                       |  |  |   |   | 
|----------------------------- |  | ------------ | ------ |  | --------------------------------------- | - | ------ | -------------------------------- |  | - | ------------------------------------- |  |  | - | - | 
|                              |  | December 31, |        |  | Quoted Prices inActive Markets(Level 1) |   |        | SignificantOther Inputs(Level 2) |  |   | SignificantObservable Inputs(Level 3) | 
|December 31, 2010             |  |              |        |  |                                         |   |        |                                  |  |   |                                       |  |  |   |   | 
|Available-for-sale securities |  | $            | 11,714 |  |                                         | $ | 11,714 |                                  |  | $ |                                      |  |  | $ |  | 
|                              |  |              |        |  |                                         |   |        |                                  |  |   |                                       |  |  |   |   | 
|December 31, 2009             |  |              |        |  |                                         |   |        |                                  |  |   |                                       |  |  |   |   | 
|Available-for-sale securities |  | $            | 9,525  |  |                                         | $ | 9,525  |                                  |  | $ |                                      |  |  | $ |  | 
|                              |  |              |        |  |                                         |   |        |                                  |  |   |                                       |  |  |   |   | 



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(4) Inventory

Inventory is comprised of the following at December 31, 2010 and 2009 (in thousands):



|                 |  |      |       |  |      |   |       | 
|---------------- |  | ---- | ----- |  | ---- | - | ----- | 
|                 |  | 2010 |       |  | 2009 |  
|Raw materials    |  | $    | 1,491 |  |      | $ | 1,001 | 
|Work in progress |  |      | 335   |  |      |   | 533   | 
|Finished goods   |  |      | 10    |  |      |   | 8     | 
|                 |  |      |       |  |      |   |       | 
|                 |  | $    | 1,836 |  |      | $ | 1,542 | 
|                 |  |      |       |  |      |   |       | 

Raw materials consist mainly of reagents, enzymes, chemicals and plates used in DNA testing. Work in
progress consists mainly of case work not yet completed and DNA testing kits that are being processed. Finished goods consist mainly of DNA testing kits that have not yet been shipped.

(5) Fixed Assets

Fixed assets are comprised of the following at
December 31, 2010 and 2009 (in thousands):



|                              |  |      |         |   |      |   |         |  
|----------------------------- |  | ---- | ------- | - | ---- | - | ------- | -
|                              |  | 2010 |         |   | 2009 |  
|Laboratory equipment          |  | $    | 13,128  |   |      | $ | 14,141  |  
|Computers and software        |  |      | 8,086   |   |      |   | 6,628   |  
|Leasehold improvements        |  |      | 5,120   |   |      |   | 5,223   |  
|Furniture and fixtures        |  |      | 1,947   |   |      |   | 1,702   |  
|                              |  |      |         |   |      |   |         |  
|                              |  |      | 28,281  |   |      |   | 27,694  |  
|Less accumulated depreciation |  |      | (22,490 | ) |      |   | (22,891 | )
|                              |  |      |         |   |      |   |         |  
|                              |  | $    | 5,791   |   |      | $ | 4,803   |  
|                              |  |      |         |   |      |   |         |  

Depreciation expense for the Companys fixed assets for the years ended December 31, 2010, 2009
and 2008 amounted to $1.8 million, $2.0 million and $2.6 million, respectively.

(6) Accrued Expenses and Other Current Liabilities

Accrued expenses and other current liabilities are comprised of the following at December 31, 2010 and 2009 (in
thousands):



|                          |  |      |       |  |      |   |       | 
|------------------------- |  | ---- | ----- |  | ---- | - | ----- | 
|                          |  | 2010 |       |  | 2009 |  
|VAT and other taxes       |  | $    | 2,747 |  |      | $ | 1,415 | 
|Professional fees         |  |      | 313   |  |      |   | 240   | 
|Employee compensation     |  |      | 1,394 |  |      |   | 475   | 
|Facility related accruals |  |      | 374   |  |      |   | 380   | 
|Restructuring             |  |      | 290   |  |      |   | 142   | 
|Other                     |  |      | 1,080 |  |      |   | 419   | 
|                          |  |      |       |  |      |   |       | 
|                          |  | $    | 6,198 |  |      | $ | 3,071 | 
|                          |  |      |       |  |      |   |       | 



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(7) Goodwill and Other Intangible Assets

The following table sets forth the activity for goodwill during the years ended December 31, 2010 and 2009 (in thousands):



|                                       |  |   |       |  
|-------------------------------------- |  | - | ----- | -
|Balance as of December 31, 2008        |  | $ | 9,336 |  
|Effect of foreign currency translation |  |   | 87    |  
|                                       |  |   |       |  
|Balance as of December 31, 2009        |  |   | 9,423 |  
|Effect of foreign currency translation |  |   | (27   | )
|                                       |  |   |       |  
|Balance as of December 31, 2010        |  | $ | 9,396 |  
|                                       |  |   |       |  

Goodwill is evaluated for impairment on an annual basis, or more frequently if impairment indicators arise,
using a fair-value based test that compares the fair value of the asset to its carrying value.

The following table sets forth
the Companys other intangible assets at December 31, 2010 and 2009 (in thousands):



|                       |  |          |        |  |                         |   |         |     |  |   |          |  |  |                         |        |  |     |   |         |   |  |   |       | 
|---------------------- |  | -------- | ------ |  | ----------------------- | - | ------- | --- |  | - | -------- |  |  | ----------------------- | ------ |  | --- | - | ------- | - |  | - | ----- | 
|                       |  | 2010     |        |  | 2009                    |  
|                       |  | Cost (1) |        |  | AccumulatedAmortization |   |         | Net |  |   | Cost (1) |  |  | AccumulatedAmortization |        |  | Net |  
|Customer list          |  | $        | 7,238  |  |                         | $ | (5,823  | )   |  | $ | 1,415    |  |  | $                       | 7,264  |  |     | $ | (5,262  | ) |  | $ | 2,002 | 
|Patents and know-how   |  |          | 4,898  |  |                         |   | (3,655  | )   |  |   | 1,243    |  |  |                         | 4,899  |  |     |   | (3,240  | ) |  |   | 1,659 | 
|Trademark/tradename    |  |          | 4,241  |  |                         |   | (3,467  | )   |  |   | 774      |  |  |                         | 4,263  |  |     |   | (3,131  | ) |  |   | 1,132 | 
|Base technology        |  |          | 6,006  |  |                         |   | (5,537  | )   |  |   | 469      |  |  |                         | 6,019  |  |     |   | (5,049  | ) |  |   | 970   | 
|Non-compete agreements |  |          | 20     |  |                         |   | (20     | )   |  |   |         |  |  |                         | 20     |  |     |   | (20     | ) |  |   |      | 
|                       |  |          |        |  |                         |   |         |     |  |   |          |  |  |                         |        |  |     |   |         |   |  |   |       | 
|Totals                 |  | $        | 22,403 |  |                         | $ | (18,502 | )   |  | $ | 3,901    |  |  | $                       | 22,465 |  |     | $ | (16,702 | ) |  | $ | 5,763 | 
|                       |  |          |        |  |                         |   |         |     |  |   |          |  |  |                         |        |  |     |   |         |   |  |   |       | 



|(1) | Cost includes the cumulative historical effect of foreign currency translation on intangible assets acquired in a prior business combination. This cumulative historical
effect of foreign currency translation amounted to $139 thousand and $201 thousand as of December 31, 2010 and 2009, respectively.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

The Companys expected future amortization expense related to intangible assets over the next five years is as follows (in thousands):



|     |  |   |       | 
|---- |  | - | ----- | 
|2011 |  | $ | 1,437 | 
|2012 |  |   | 723   | 
|2013 |  |   | 655   | 
|2014 |  |   | 234   | 
|2015 |  |   | 109   | 

(8) Restructuring

During the year ended December 31, 2010, the Company recognized $1.7 million in restructuring expenses related to the consolidation
of its East Lansing, Michigan paternity testing operations into its Dayton, Ohio facility and the consolidation of its Nashville CODIS testing operation into its Dallas, Texas facility, an increase of $1.6 million as compared to $161 thousand during
2009. The Company announced the planned East Lansing consolidation on October 20, 2009 and completed this consolidation during the quarter ended March 31, 2010.



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The Company announced the planned Nashville consolidation on January 14, 2010, and completed this consolidation during the quarter ended September 30, 2010. The expenses in 2010 relate
primarily to employee severance costs and facility closure costs.

In connection with these consolidations, the Company
expects to incur aggregate restructuring charges and cash expenditures of $1.8 million to $2.3 million, the majority of which already have been incurred. The Company achieved these consolidations within the time frames and range of costs previously
disclosed in its periodic filings with the Securities and Exchange Commission. Such charges and expenditures include: severance and retention bonuses for employees in the range of $990 thousand to $1.2 million; relocation in the range of $135
thousand to $185 thousand; lease termination costs in the range of $200 thousand to $300 thousand; and equipment relocation and reinstallation costs in the range of $375 thousand to $485 thousand.

The restructuring liability is included as part of accrued expenses and other current liabilities on the Companys consolidated
balance sheet.

A summary of the restructuring activity in 2010 and 2009 is as follows (in thousands):



|                                                    |  |       |        |  
|--------------------------------------------------- |  | ----- | ------ | -
|                                                    |  | Total |       
|Restructuring liability as of December 31, 2008     |  | $     |       |  
|Charge recorded in the year ended December 31, 2009 |  |       | 142    |  
|Restructuring liability as of December 31, 2009     |  | $     | 142    |  
|Charge recorded in the year ended December 31, 2010 |  |       | 1,725  |  
|Cash payments in the year ended December 31, 2010   |  |       | (1,577 | )
|                                                    |  |       |        |  
|Restructuring liability as of December 31, 2010     |  | $     | 290    |  
|                                                    |  |       |        |  

(9) Debt

As part of the acquisition of ReliaGene on October 31, 2007, the Company assumed $948 thousand in debt comprised of a line of credit and various notes payable with outstanding balances of $260
thousand and $688 thousand, respectively. The line of credit was fully paid off during 2008 with a then outstanding balance of $170 thousand. The notes payable, which were secured by ReliaGenes equipment, had interest rates ranging from 4.50%
to 8.50% and maturity dates ranging from June 30, 2009 through September 5, 2011. In April 2009, the Company fully paid off the ReliaGene notes payable, along with all accrued interest.

(10) Income Taxes

The
provision for income taxes is based on loss from continuing operations before income taxes reported for financial statement purposes. The components are as follows (in thousands):



|                         |  |                         |         |   |      |   |        |      |  |   |        |  
|------------------------ |  | ----------------------- | ------- | - | ---- | - | ------ | ---- |  | - | ------ | -
|                         |  | Year ended December 31, |        
|                         |  | 2010                    |         |   | 2009 |   |        | 2008 | 
|United States            |  | $                       | (10,245 | ) |      | $ | (3,296 | )    |  | $ | (6,107 | )
|Foreign                  |  |                         | 7,158   |   |      |   | 1,719  |      |  |   | (82    | )
|                         |  |                         |         |   |      |   |        |      |  |   |        |  
|Loss before income taxes |  | $                       | (3,087  | ) |      | $ | (1,577 | )    |  | $ | (6,189 | )
|                         |  |                         |         |   |      |   |        |      |  |   |        |  



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NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



The components of income tax expense (benefit) are summarized as follows (in thousands):



|                                      |  |                         |       |   |      |   |      |      |  |   |        |  
|------------------------------------- |  | ----------------------- | ----- | - | ---- | - | ---- | ---- |  | - | ------ | -
|                                      |  | Year ended December 31, |      
|                                      |  | 2010                    |       |   | 2009 |   |      | 2008 | 
|Current income tax expense (benefit): |  |                         |       |   |      |   |      |      |  |   |        |  
|Federal                               |  | $                       | (39   | ) |      | $ |     |      |  | $ |       |  
|State                                 |  |                         | (282  | ) |      |   |     |      |  |   | (1,468 | )
|Foreign                               |  |                         | 1,277 |   |      |   | 168  |      |  |   | (193   | )
|                                      |  |                         |       |   |      |   |      |      |  |   |        |  
|Total current expense (benefit)       |  |                         | 956   |   |      |   | 168  |      |  |   | (1,661 | )
|                                      |  |                         |      
|Deferred tax expense (benefit)        |  |                         |       |   |      |   |      |      |  |   |        |  
|Federal                               |  | $                       | 243   |   |      | $ |     |      |  | $ |       |  
|State                                 |  |                         | 14    |   |      |   |     |      |  |   |       |  
|Foreign                               |  |                         | 222   |   |      |   | (203 | )    |  |   | (47    | )
|                                      |  |                         |       |   |      |   |      |      |  |   |        |  
|Total deferred expense (benefit)      |  |                         | 479   |   |      |   | (203 | )    |  |   | (47    | )
|                                      |  |                         |      
|Income tax expense (benefit)          |  | $                       | 1,435 |   |      | $ | (35  | )    |  | $ | (1,708 | )
|                                      |  |                         |       |   |      |   |      |      |  |   |        |  

During 2010, the Company recognized a current foreign tax expense of $1.3 million and deferred foreign tax
expense of $222 thousand, primarily for our profitable business in the UK and we recognized $257 thousand in federal and state deferred taxes. In addition, the Company recorded a tax benefit of $39 thousand relating to the recovery of Federal
Research Credits and $282 thousand associated with the sale of some of its state net operating loss, or NOL, carryforwards. No tax benefit was recorded relating to the Companys US business losses as management deemed that it was not
likely that such tax benefit would be realized.

During 2009, the Company recognized a current foreign tax expense of $168
thousand. Included in the expense is a current benefit of $192 thousand relating to certain allowances and deductions taken on our tax returns.

During 2008, the Company recognized a current foreign tax benefit of $193 thousand, primarily from the reversal of a reserve for tax return positions taken on its UK subsidiary tax return filings as a
result of expired statutes of limitations and a deferred foreign tax benefit of $47 thousand. In addition, the Company recorded a tax benefit of $1.5 million associated with the sale of some of its state NOL carryforwards. No tax benefit was
recorded relating to our US business losses or other US deferred tax assets as management deemed that it was not more likely than not that such tax benefit would be realized.

The Company adopted the provisions of FASB Interpretation No. 48, Accounting for Uncertainty in Income Taxes (FIN 48) (FASB ASC
740), on January 1, 2007. During the year ended December 31, 2010 the Company decreased its reserve for unrecognized tax benefits by $225 thousand relating to certain allowances and deductions taken on the Companys tax returns since
they were effectively settled in the U.K. The tax year 2009 remains open to examination by the UK taxing authorities and the tax years 2007 to 2009 remain open to examination by the US taxing authorities. In addition, the US taxing authorities may
examine the tax years from 1996 through 2006, but generally are barred from adjusting the tax liabilities in excess of the net operating losses generated in any of those tax years. As of December 31, 2010 there are no unrecognized tax benefits
that, if recognized, would affect the effective tax rate. The Company records interest and penalties relating to income tax exposures in income tax expense.



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A reconciliation of the beginning and ending amount of unrecognized tax benefits is as
follows (in thousands):



|                                                             |  |   |      |  
|------------------------------------------------------------ |  | - | ---- | -
|Balance at January 1, 2009                                   |  | $ |     |  
|Additions based on tax positions related to the current year |  |   | 225  |  
|Additions for tax positions of prior years                   |  |   |     |  
|Lapse of statute                                             |  |   |     |  
|Settlements                                                  |  |   |     |  
|                                                             |  |   |      |  
|Balance at December 31, 2009                                 |  | $ | 225  |  
|Additions for tax positions of prior years                   |  |   |      |  
|Reductions for tax positions of prior years                  |  |   | (225 | )
|Lapse of statute                                             |  |   |     |  
|Settlements                                                  |  |   |     |  
|                                                             |  |   |      |  
|Balance at December 31, 2010                                 |  | $ |     |  
|                                                             |  |   |      |  

The tax effects of temporary differences and loss and credit carryforwards that give rise to significant
portions of the deferred tax assets and liabilities of the Company at December 31, 2010 and 2009 are presented below (in thousands):



|                                                 |  |      |         |   |      |   |         |  
|------------------------------------------------ |  | ---- | ------- | - | ---- | - | ------- | -
|                                                 |  | 2010 |         |   | 2009 |  
|Deferred tax assets:                             |  |      |         |   |      |   |         |  
|Bad debt allowance and inventory reserve         |  | $    | 44      |   |      | $ | 78      |  
|Stock-based compensation                         |  |      | 1,436   |   |      |   | 1,141   |  
|Deferred revenue                                 |  |      | 247     |   |      |   | 211     |  
|NOL carryforwards                                |  |      | 87,414  |   |      |   | 89,073  |  
|Research and development and foreign tax credits |  |      | 3,697   |   |      |   | 3,812   |  
|Accrued restructuring expenses                   |  |      | 94      |   |      |   | 94      |  
|Accrued expenses                                 |  |      | 80      |   |      |   | 92      |  
|Amortization and depreciation                    |  |      | 2,089   |   |      |   | 2,707   |  
|Investments                                      |  |      | 279     |   |      |   | 280     |  
|                                                 |  |      |         |   |      |   |         |  
|Total gross deferred tax assets                  |  |      | 95,456  |   |      |   | 97,488  |  
|Less valuation allowance                         |  |      | (93,957 | ) |      |   | (94,848 | )
|                                                 |  |      |         |   |      |   |         |  
|Net deferred tax assets                          |  |      | 1,423   |   |      |   | 2,640   |  
|Deferred tax liabilities:                        |  |      |         |   |      |   |         |  
|Intangible assets                                |  |      | (1,103  | ) |      |   | (1,847  | )
|                                                 |  |      |         |   |      |   |         |  
|Net deferred taxes                               |  | $    | 320     |   |      | $ | 793     |  
|                                                 |  |      |         |   |      |   |         |  

At December 31, 2010 and 2009, valuation allowances of $94.0 million and $94.8 million, respectively,
have been recognized to offset the net deferred tax assets related to the US operations of the Company, as realization of these assets is uncertain. The net change in the valuation allowance for 2010 and 2009 was a decrease of $800 thousand and a
decrease of $5.1 million, respectively, related primarily to amortization, depreciation, and the expiration of state NOL carryforwards.

As of December 31, 2010, the Company has $247.6 million and $36.1 million of federal and state NOL carryforwards, respectively, available to offset future taxable income. Some of the federal and
state NOL carryforwards the Company has generated or acquired have begun to expire. Utilization of NOL carryforwards to



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offset future taxable income, if any, may be substantially limited due to the change of ownership provisions in the Tax Reform Act of 1986, or the Act. The Act provides for a
limitation on the annual use of NOL carryforwards and research and development credits following certain ownership changes, as defined by the Act, which could significantly limit the Companys ability to utilize or sell these carryforwards and
research and development credits. The Company has determined that ownership changes occurred, as defined by the Act, in 1999 and 2001. As a result only $220.5 million of the NOL set forth above is available for use at December 31, 2010. The
remaining NOL carryover of $27.1 million will become available for use in various amounts over the period 2011 through 2019. The Company may have experienced other ownership changes as a result of past financings and may experience others in
connection with future financings. Accordingly, the Companys ability to utilize the aforementioned federal NOL carryforwards may be further limited.

At December 31, 2010, the Company had federal and New Jersey research and development and federal foreign tax credit carryforwards of $3.8 million, which will begin expiring in 2016.

The following table represents a reconciliation of the Companys income tax expense to amounts computed by applying the statutory US
federal income tax rate of 35% to loss before income taxes (in thousands):



|                                                      |  |                         |        |   |      |   |        |      |  |   |        |  
|----------------------------------------------------- |  | ----------------------- | ------ | - | ---- | - | ------ | ---- |  | - | ------ | -
|                                                      |  | Year ended December 31, |       
|                                                      |  | 2010                    |        |   | 2009 |   |        | 2008 | 
|Computed expected tax benefit                         |  | $                       | (1,080 | ) |      | $ | (552   | )    |  | $ | (2,166 | )
|State income taxes, net of federal income tax benefit |  |                         | (121   | ) |      |   | (64    | )    |  |   | (1,468 | )
|Foreign operations                                    |  |                         | (944   | ) |      |   | (625   | )    |  |   | (37    | )
|Write down of unrecognized income tax benefits        |  |                         | 4,228  |   |      |   |       |      |  |   | (175   | )
|Permanent differences                                 |  |                         | 140    |   |      |   | 85     |      |  |   | 545    |  
|Expiration of tax attribute carryforwards             |  |                         |       |   |      |   | 1,727  |      |  |   |       |  
|Change in effective state tax rate                    |  |                         | 180    |   |      |   | 4,536  |      |  |   |       |  
|Change in valuation allowance                         |  |                         | (892   | ) |      |   | (5,142 | )    |  |   | 1,593  |  
|Other                                                 |  |                         | (76    | ) |      |   |       |      |  |   |       |  
|                                                      |  |                         |        |   |      |   |        |      |  |   |        |  
|                                                      |  | $                       | 1,435  |   |      | $ | (35    | )    |  | $ | (1,708 | )
|                                                      |  |                         |        |   |      |   |        |      |  |   |        |  

The Company sold certain state net operating loss, or NOL, carryforwards in accordance with the State of New
Jerseys Corporation Business Tax Benefit Certificate Transfer program, or the Program. During 2010 and 2008, the Company completed the sale of $13.7 million and $21.3 million, respectively, of New Jersey NOL carryforwards. The Company
generated tax benefits of $282 thousand, and $749 thousand for 2010 and 2008, respectively. The Company was not eligible for this program in 2009.

The Company has made no provision for US taxes on cumulative earnings of foreign subsidiaries as those earnings are intended to be reinvested for an indefinite period of time. The Companys
cumulative undistributed earnings of foreign subsidiaries amounted to $15.4 million at December 31, 2010. Determination of the potential amount of unrecognized deferred US income tax liability related to such reinvested income is not
practicable because of numerous assumptions associated with this hypothetical calculation. However, foreign tax credits would be available to reduce some portion of this amount. As of December 31, 2010 and based on tax laws in effect as of this
date, it is the Companys intention to indefinitely reinvest the undistributed earnings of foreign subsidiaries.

(11) Significant
Customers and Geographic Information

During the year ended December 31, 2010, the Company generated approximately
$16.1 million, or 25%, of its total revenues through an agreement with one UK government customer. No single customer accounted for more than 10% of the Companys revenues in 2009 or 2008.



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The Company has significant international operations, primarily in the UK. During the
years ended December 31, 2010, 2009 and 2008, the Company recorded revenues from international customers of $40.0 million, or 63%, $29.5 million, or 50%, and 26.4 million, or 46%, respectively, of total revenues.

During each of the years ended December 31, 2010 and 2009, the Company has long-lived assets of $2.5 million and $2.7 million
located in the US, and $3.3 million and $2.1 million located in the UK, respectively.

(12) Stockholder Rights Plan

On May 16, 2001, the Companys Board of Directors adopted a Stockholder Rights Plan (Rights Plan), which is designed to protect
the Companys stockholders in the event of any takeover offer. On May 16, 2001, the Companys Board of Directors declared a dividend of one preferred stock purchase right (a Right) for each outstanding share of the Companys
common stock to stockholders of record at the close of business on May 31, 2001 (the Record Date). Each Right entitles the registered holder to purchase from the Company one one-hundredth of a share of Series A junior participating preferred
stock, $0.001 par value per share, at an initial purchase price of $40.00 in cash, subject to adjustment.

Initially, the
Rights will be attached to all common stock certificates representing shares then outstanding, and no separate Rights certificates will be distributed. The Rights will separate from the common stock and a Distribution Date, as defined in the Rights
Plan, will occur if certain events as described below transpire. Rights will also be attached to all shares of common stock issued following the Record Date but prior to the Distribution Date. The Rights are not exercisable until the Distribution
Date and will expire at the close of business on May 16, 2011, unless earlier redeemed by the Company. The Distribution Date has not occurred as of December 31, 2010.

In the event that a person or a group of affiliated or associated persons becomes the beneficial owner of more than 15% of the then
outstanding shares of common stock (except pursuant to an offer for all outstanding shares of common stock which the Board of Directors determines to be fair to, and otherwise in the best interests of, the Company and its stockholders), each holder
of a Right will thereafter have the right to receive, upon exercise, that number of shares of common stock (or, in certain circumstances, cash, property or other securities of the Company) which equals the exercise price of the Right divided by
one-half of the current market price (as defined in the Rights Plan) of the common stock at the date of the occurrence of the event. However, Rights are not exercisable following the occurrence of any of the events set forth above until such time as
the Rights are no longer redeemable by the Company. In the event that the Company is acquired in a merger or other business combination transaction in which the Company is not the surviving corporation, or, more than 50% of the Companys assets
or earning power is sold or transferred, each holder of a Right shall thereafter have the right to receive, upon exercise, that number of shares of common stock of the acquiring company which equals the exercise price of the Right divided by
one-half of the current market price (as defined in the Rights Plan) of such common stock at the date of the occurrence of the event.

(13)
Employee Stock Purchase Plan

During the year ended December 31, 2003, the Companys stockholders approved the
2003 Employee Stock Purchase Plan (the ESPP). The ESPP has not yet been implemented and there are no plans to implement the ESPP at this time. Employees who own more than 5% of the Companys stock may not participate in the ESPP. At the
beginning of an offering period, as defined in the ESPP document, each participant receives an option to purchase shares of common stock at the end of each accumulation period, at an exercise price equal to the lesser of 85% of (i) the fair
market value of the common stock on the last trading day before the start of the applicable offering period, or (ii) the fair market value of the common stock on the last trading day of the accumulation



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period. The maximum number of shares that may be purchased by any participant in the ESPP in an accumulation period is 25,000 shares. No participant may purchase shares having an aggregate fair
market value greater than $25 thousand in any calendar year. A total of 650,000 shares of the Companys common stock are reserved for issuance under the ESPP as of December 31, 2010. The ESPP may be amended, suspended or terminated at any
time by the Board of Directors. Amendments affecting any increase in the number of shares available under the ESPP and any other amendment to the extent required by applicable law or regulation shall be subject to the approval of the Companys
stockholders.

(14) Employee Benefit Plan

The Company sponsors a defined contribution 401(k) savings plan (the 401(k) Plan) covering all US-based employees of the Company. Participants can contribute up to 15% of their pretax annual compensation
to the 401(k) Plan, subject to certain limitations. The Company matches 50% of the participants contribution, up to 4% of compensation. For the years ended December 31, 2010, 2009 and 2008, the Companys contributions amounted to
$142 thousand, $146 thousand and $161 thousand, respectively, in accordance with the terms of the 401(k) Plan.

(15) Commitments and
Contingencies

The Company leases office and laboratory facilities and certain equipment under non-cancelable operating
lease arrangements. Several of the Companys facility leases contain renewal options and rent escalation clauses. Rent expense amounted to $2.0 million in 2010, $1.9 million in 2009, and $2.0 million in 2008. Future minimum rental commitments
required by such leases as of December 31, 2010 are as follows (in thousands):



|           |  |   |       | 
|---------- |  | - | ----- | 
|2011       |  | $ | 1,593 | 
|2012       |  |   | 1,179 | 
|2013       |  |   | 699   | 
|2014       |  |   | 514   | 
|2015       |  |   | 474   | 
|Thereafter |  |   | 495   | 
|           |  |   |       | 
|           |  | $ | 4,954 | 
|           |  |   |       | 

(16) Accumulated Other Comprehensive Income (Loss)

The accumulated balances for each classification of items within accumulated other comprehensive income (loss) are as follows (in
thousands):



|                                        |  |                            |        |   |                                      |   |     |                                            |  |   |        |  
|--------------------------------------- |  | -------------------------- | ------ | - | ------------------------------------ | - | --- | ------------------------------------------ |  | - | ------ | -
|                                        |  | Foreigncurrencytranslation |        |   | Unrealizedgains(losses) onsecurities |   |     | Accumulatedothercomprehensiveincome (loss) | 
|Balance at January 1, 2008              |  | $                          | 3,852  |   |                                      | $ |    |                                            |  | $ | 3,852  |  
|Foreign currency translation adjustment |  |                            | (4,832 | ) |                                      |   | () |                                            |  |   | (4,832 | )
|                                        |  |                            |        |   |                                      |   |     |                                            |  |   |        |  
|Balance at December 31, 2008            |  |                            | (980   | ) |                                      |   |    |                                            |  |   | (980   | )
|Foreign currency translation adjustment |  |                            | 1,323  |   |                                      |   |    |                                            |  |   | 1,323  |  
|                                        |  |                            |        |   |                                      |   |     |                                            |  |   |        |  
|Balance at December 31, 2009            |  |                            | 343    |   |                                      |   |    |                                            |  |   | 343    |  
|Foreign currency translation adjustment |  |                            | (279   | ) |                                      |   | (28 | )                                          |  |   | (307   | )
|                                        |  |                            |        |   |                                      |   |     |                                            |  |   |        |  
|Balance at December 31, 2010            |  | $                          | 64     |   |                                      | $ | (28 | )                                          |  | $ | 36     |  
|                                        |  |                            |        |   |                                      |   |     |                                            |  |   |        |  



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(17) Legal Proceedings

On or about November 21, 2001, a complaint was filed in the United States District Court for the Southern District of New York naming the Company as a defendant, along with certain of the
Companys former officers and underwriters. An amended complaint was filed on April 19, 2002. The complaint, as amended, purportedly was filed on behalf of persons purchasing the Companys stock between May 4, 2000 and
December 6, 2000, and alleges violations of Sections 11, 12(a)(2) and 15 of the Securities Act of 1933, as amended, and Sections 10(b) and 20(a) of the Securities Exchange Act of 1934, as amended, and Rule 10b-5 promulgated thereunder. The
amended complaint alleges that, in connection with the Companys May 5, 2000 initial public offering, or IPO, the defendants failed to disclose additional and excessive commissions purportedly solicited by and paid to the underwriter
defendants in exchange for allocating shares of our stock to preferred customers and alleged agreements among the underwriter defendants and preferred customers tying the allocation of IPO shares to agreements to make additional aftermarket
purchases at pre-determined prices. Plaintiffs claim that the failure to disclose these alleged arrangements made our registration statement on Form S-1 filed with the SEC in May 2000 and the prospectus, a part of the registration statement,
materially false and misleading. On or about July 15, 2002, the Company filed a motion to dismiss all of the claims against the Company and the Companys former officers. On October 9, 2002, the Court dismissed without prejudice only
the Companys former officers, Dale R. Pfost and Donald R. Marvin, from the litigation in exchange for the Company entering into a tolling agreement with plaintiffs executive committee. On February 19, 2003, the Company received
notice of the Courts decision to dismiss the Section 10(b) claims against the Company. Plaintiffs and the defendant issuers involved in related IPO securities litigation, including us, have agreed in principal on a settlement that, upon a
one-time surety payment by the defendant issuers insurers, would release the defendant issuers and the individual officers and directors from claims and any future payments or out-of-pocket costs. On March 10, 2005, the Court issued a
memorandum and order (i) preliminarily approving the settlement, contingent on the parties agreement on modifications of the proposed bar order in the settlement documents, (ii) certifying the parties proposed settlement
classes, (iii) certifying the proposed class representatives for the purposes of the settlement only and (iv) setting a further hearing for the purposes of (a) making a final determination as to the form, substance and program of
notice of proposed settlement and (b) scheduling a public fairness hearing in order to determine whether the settlement can be finally approved by the Court. On April 24, 2006, the Court held a fairness hearing and took the motion for
final approval under advisement. On October 5, 2009, the Court granted the plaintiffs motion for an order of final approval of the settlement, plan of allocation and certification of the class. Such settlement does not require any payment
by the Company to the plaintiffs. The defendant issuers share of the settlement amount is funded by the insurers. Notices of appeal have been filed by six groups of appellants. None of the notices state the basis for appeal.

In related proceedings against the underwriters, the United States Court of Appeals for the Second Circuit ruled on December 5, 2006
that the certification by the District Court for the Southern District of New York of class actions against the underwriters in six focus cases was vacated and remanded for further proceedings. In so doing, the Second Circuit ruled that
the cases pending on this appeal may not be certified as class actions. On April 6, 2007, the Second Circuit denied the plaintiffs petition for rehearing, and no further appeals have been taken.

As a result of the Second Circuits ruling, the plaintiffs and the issuers stipulated on June 22, 2007 that the Stipulation and
Agreement of Settlement with Defendant Issuers and Individuals, which was originally submitted to the Court on June 10, 2004, was terminated, which resolved the motion for final approval of the class action settlement with the issuers and
individual defendants. The Court entered the parties stipulation as an Order on June 25, 2007. As a result of these developments, the plaintiffs have filed amended complaints against the underwriters and focus case issuers and
individuals and are attempting to certify a class action.





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In response to the amended complaints, the underwriters and focus case
issuers moved to dismiss the amended complaints. On March 26, 2008, the motion to dismiss was granted in part and denied in part. As a result, the Court will proceed with the plaintiffs amended complaints against the underwriters and
focus case issuers to determine whether class actions can be certified.

The Company is a defendant in litigation
pending in the United States District Court for the Southern District of New York entitled Enzo Biochem, Inc. et al. (Enzo) v. Amersham PLC, et al. (Amersham), filed in October 2002. By their complaint, plaintiffs allege that certain defendants
(i) breached their distributorship agreements by selling certain products for commercial development (which they allege was not authorized), (ii) infringed plaintiffs patents through the sale and use of certain products, and
(iii) are liable for unfair competition and tortious interference with contractual relations. The Company did not have a contractual relationship with plaintiffs, but the Company is alleged to have purchased the product at issue from one of the
other defendants. The Company has sold the business unit that was allegedly engaged in the unlawful conduct. As a result, there is no relevant injunctive relief to be sought from the Company. The complaint seeks damages in an undisclosed amount.
Most of the fact discovery in the case has been taken, and a Markman hearing to construe the patent claims was conducted in early July 2005. On July 17, 2006, the Court ruled in the Companys favor on the construction of the patents
asserted against the Company, and the co-defendants, including the Company, moved for summary judgment on all claims against us in January 2007. A hearing on the defendants motions for summary judgment occurred on July 17-18, 2007, and
the Court reserved ruling on the motions, taking them under advisement. Such matter has been delayed due to the death of the judge and the assignment of a new judge.

In other litigation brought by Enzo against another defendant under the same patents asserted against the Company, a Connecticut Federal Court has invalidated the patents asserted there and asserted
against the Company in the New York case. That decision was reversed in part by the Court of Appeals on March 26, 2010. As a result of these developments, the Enzo v. Amersham case has been stayed pending the outcome of the
Connecticut Federal Court case.

On February 12, 2010, a complaint was filed in the United States District Court for the
Western District of Wisconsin by Genetic Technologies Limited naming the Company as a defendant, along with eight other companies. The complaint, entitled Genetic Technologies Limited v. Beckman Coulter, Inc., et al., alleges that

the defendants infringed U.S. Patent No. 5,612,179 through the sale and use of certain products and services. There is no request for injunctive
relief by the plaintiff. The Company has been served with a complaint and has filed an answer. Discovery is currently being conducted. The Company believes that the allegations are without merit and intends to vigorously defend itself against such
claims.

Additionally, the Company has certain other claims against it arising from the normal course of its business. The
ultimate resolution of such matters, including those cases disclosed above, in the opinion of management, will not have a material effect on the Companys financial position and liquidity, but could have a material impact on its results of
operations for any reporting period.



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(18) Quarterly Financial Data (Unaudited)

The following tables represent certain unaudited consolidated quarterly financial information for each of the quarters in 2010 and 2009.
In the opinion of the Companys management, this quarterly information has been prepared on the same basis as the annual consolidated financial statements and includes all adjustments (consisting only of normal recurring adjustments, except as
disclosed below) necessary to present fairly the information for the periods presented (in thousands, except per share data):



|                                              |  |                |        |   |              |   |        |                   |  |   |                  |   |  |   |        |  
|--------------------------------------------- |  | -------------- | ------ | - | ------------ | - | ------ | ----------------- |  | - | ---------------- | - |  | - | ------ | -
|                                              |  | Quarters ended |       
|                                              |  | March 31,2010  |        |   | June 30,2010 |   |        | September 30,2010 |  |   | December 31,2010 |  
|Total revenues                                |  | $              | 14,130 |   |              | $ | 15,684 |                   |  | $ | 17,292           |   |  | $ | 16,615 |  
|Gross margin                                  |  |                | 4,750  |   |              |   | 5,116  |                   |  |   | 6,512            |   |  |   | 5,520  |  
|Loss before income taxes                      |  |                | (1,631 | ) |              |   | (1,130 | )                 |  |   | 200              |   |  |   | (525   | )
|Net income (loss)                             |  |                | (2,035 | ) |              |   | (1,585 | )                 |  |   | (665             | ) |  |   | (237   | )
|Basic and diluted net income (loss) per share |  | $              | (0.07  | ) |              | $ | (0.05  | )                 |  | $ | (0.02            | ) |  | $ | (0.01  | )
|                                              | 
|                                              |  | Quarters ended |       
|                                              |  | March 31,2009  |        |   | June 30,2009 |   |        | September 30,2009 |  |   | December 31,2009 |  
|Total revenues                                |  | $              | 13,965 |   |              | $ | 14,687 |                   |  | $ | 14,674           |   |  | $ | 15,737 |  
|Gross margin                                  |  |                | 4,785  |   |              |   | 5,130  |                   |  |   | 4,876            |   |  |   | 5,723  |  
|Loss before income taxes                      |  |                | (1,029 | ) |              |   | (465   | )                 |  |   | (426             | ) |  |   | 344    |  
|Net income (loss)                             |  |                | (1,172 | ) |              |   | (603   | )                 |  |   | (625             | ) |  |   | 858    |  
|Basic and diluted net income (loss) per share |  | $              | (0.04  | ) |              | $ | (0.02  | )                 |  | $ | (0.02            | ) |  | $ | 0.03   |  

During the fourth
quarter of 2009, the Company granted a worldwide license to Illumina, Inc. for the commercial development of the Companys proprietary single base nucleotide extension technology for the diagnostic and forensic fields. Under the terms of the
license transaction, the Company received a fee of $850 thousand as well as the potential of an additional $150 thousand in contingent milestone payments. During the fourth quarter of 2009, the Company recognized $ 850 thousand as revenues. The
Company does not have future material obligations related to Illumina. The Company will also collect royalties received by Illumina through any subcontracting arrangements. Additionally, the licensing agreement allows the Company to purchase certain
Illumina product offerings utilizing the patents as a preferred customer. Under the agreement, Orchid Cellmark reserves the rights to use the licensed patents for all fields of use.

(19) Subsequent Event

In accordance with ASC 855-10, the Company has
evaluated subsequent events through the date these consolidated financial statements were issued. No significant events occurred subsequent to the balance sheet date but prior to the filing of this report that would have a material impact on the
Consolidated Financial Statements.



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|Item 9. | CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURE
|------- | ------------------------------------------------------------------------------------

Not applicable.



|Item 9A. | CONTROLS AND PROCEDURES
|-------- | -----------------------

Disclosure
Controls and Procedures.

Our principal executive officer and principal financial officer, after evaluating the
effectiveness of our disclosure controls and procedures (as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended, or the Exchange Act) as of the end of the period covered by this Annual Report on Form 10-K,
have concluded that, based on such evaluation, our disclosure controls and procedures were effective to ensure that information required to be disclosed by us in the reports that we file or submit under the Exchange Act is recorded, processed,
summarized and reported, within the time periods specified in the SECs rules and forms, and is accumulated and communicated to our management, including our principal executive and principal financial officers, or persons performing similar
functions, as appropriate to allow timely decisions regarding required disclosure.

Managements Report on Internal Control over
Financial Reporting.

Our management is responsible for establishing and maintaining adequate internal control over
financial reporting, as such term is defined in Rules 13a-15(f) and 15d-15(f) under the Exchange Act. Our internal control system is a process designed by, or under the supervision of, our President and principal executive officer and principal
financial officer and effected by our Board of Directors, management and other personnel to provide reasonable assurance regarding the reliability of our financial reporting and the preparation of financial statements for external reporting purposes
in accordance with generally accepted accounting principles.

Our internal control over financial reporting includes policies
and procedures that:



| |  |  | pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect transactions and disposition of assets;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------



| |  |  | provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally
accepted accounting principles, and that receipts and expenditures are being made only in accordance with the authorization of our management and directors; and
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use or disposition of our assets that could have a
material effect on our financial statements.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Because of inherent limitations, internal control over
financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of
compliance with the policies or procedures may deteriorate.

Management assessed the effectiveness of our internal control
over financial reporting as of December 31, 2010. In making this assessment, they used the control criteria framework of the Committee of Sponsoring Organizations, or COSO, of the Treadway Commission published in its report entitled Internal
Control-Integrated Framework. Based on this evaluation, our management has concluded that our internal control over financial reporting was effective as of December 31, 2010 based on those criteria.

Changes in Internal Control over Financial Reporting.

There were no changes in our internal control over financial reporting identified in connection with the evaluation of such internal control that occurred during the quarter ended December 31, 2010
that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.



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Limitations on the Effectiveness of Controls.

The Companys disclosure controls and procedures are designed to provide reasonable assurance of achieving their objectives and our
principal executive officer and principal financial officer have concluded that the Companys disclosure controls and procedures are effective at that reasonable assurance level. However, our management, including our principal executive
officer and principal financial officer, does not expect that our disclosure controls and procedures or our internal control over financial reporting will prevent all error and all fraud. A control system, no matter how well conceived and operated,
can provide only reasonable, not absolute, assurance that the objectives of the control system are met. Further, the design of a control system must reflect the fact that there are resource constraints, and the benefits of controls must be
considered relative to their costs. Because of the inherent limitations in all control systems, no evaluation of controls can provide absolute assurance that all control issues and instances of fraud, if any, within an organization have been
detected. These inherent limitations include the realities that judgments in decision-making can be faulty, and that breakdowns can occur because of simple error or mistake.

Additionally, controls can be circumvented by the individual acts of some persons, by collusion of two or more people, or by management override of the control. The design of any system of controls also
is based in part upon certain assumptions about the likelihood of future events, and there can be no assurance that any design will succeed in achieving our stated goals under all potential future conditions. Over time, controls may become
inadequate because of changes in conditions, or the degree of compliance with the policies or procedures may deteriorate. Because of the inherent limitations in a cost-effective control system, misstatements due to error or fraud may occur and not
be detected.



|Item 9B. | OTHER INFORMATION
|-------- | -----------------

For
information concerning the number of votes cast for, against or withheld, abstentions and broker non-votes, with respect to each matter presented at our 2010 Annual Meeting of Stockholders, please see our Current Report on Form 8-K filed with the
SEC on November 12, 2010.

PART III



|Item 10. | DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE
|-------- | ------------------------------------------------------

The response to this item is incorporated by reference from the discussion responsive thereto under the captions Management and Corporate Governance, Section 16(a) Beneficial Ownership
Reporting Compliance and Code of Business Conduct and Ethics in our Proxy Statement for the 2011 Annual Meeting of Stockholders.



|Item 11. | EXECUTIVE COMPENSATION
|-------- | ----------------------

The response to this item is incorporated by reference from the discussion responsive thereto under the captions Executive Officer
and Director Compensation in our Proxy Statement for the 2011 Annual Meeting of Stockholders.



|Item 12. | SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERS
|-------- | ----------------------------------------------------------------------------------------------

The response to this item is incorporated by reference from the discussion responsive thereto under the captions Security
Ownership and Executive Officer and Director CompensationEquity Compensation Plan Information in our Proxy Statement for the 2011 Annual Meeting of Stockholders.



|Item 13. | CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE
|-------- | -------------------------------------------------------------------------

The response to this item is incorporated by reference from the discussion responsive thereto under the captions Certain Relationships and Related Person Transactions and Management and
Corporate GovernanceThe Board of Directors in our Proxy Statement for the 2011 Annual Meeting of Stockholders.



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|Item 14. | PRINCIPAL ACCOUNTANT FEES AND SERVICES
|-------- | --------------------------------------

The response to this item is incorporated by reference from the discussion responsive thereto under the caption Ratification of Appointment of Grant Thornton LLP in our Proxy Statement for the
2011 Annual Meeting of Stockholders.



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PART IV



|Item 15. | EXHIBITS AND FINANCIAL STATEMENT SCHEDULES
|-------- | ------------------------------------------



|(1) | Financial Statements. See Index to Consolidated Financial Statements at Item 8, page 37 of this report.
|--- | -------------------------------------------------------------------------------------------------------



|(2) | Financial Statement Schedules.
|--- | ------------------------------

Schedule II.
Valuation and Qualifying Accounts for the years ended December 31, 2010, 2009 and 2008.

(3) Exhibits

The following is a list of exhibits filed as part of this Annual Report on Form 10-K.



|              |  |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
|------------- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|ExhibitNumber |  | Description                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
|              | 
|3.1(1)        |  | Restated Certificate of Incorporation of the Registrant, dated May 10, 2000 (filed as Exhibit 3.1)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
|              | 
|3.2(1)        |  | Certificate of Amendment to the Restated Certificate of Incorporation of the Registrant, dated June 12, 2001 (filed as Exhibit 3.2)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
|              | 
|3.3(1)        |  | Certificate of Amendment to the Restated Certificate of Incorporation of the Registrant, dated June 14, 2002 (filed as Exhibit 3.3)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
|              | 
|3.4(2)        |  | Certificate of Amendment to the Restated Certificate of Incorporation of the Registrant, dated March 30, 2004 (filed as Exhibit 4.10)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
|              | 
|3.5(2)        |  | Certificate of Amendment to the Restated Certificate of Incorporation of the Registrant, dated June 14, 2005 (filed as Exhibit 4.11)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|              | 
|3.6(1)        |  | Certificate of Designation, Preferences, and Rights of Series A Junior Participating Preferred Stock of the Registrant, dated August 1, 2001 (filed as Exhibit 3.4)                                                                                                                                                                                                                                                                                                                                                                                                                                                     
|              | 
|3.7(3)        |  | Certificate of Designations, Preferences and Rights of Series A Convertible Preferred Stock of the Registrant, dated March 31, 2003 (filed as Exhibit 3.1)                                                                                                                                                                                                                                                                                                                                                                                                                                                              
|              | 
|3.8(4)        |  | Third Amended and Restated Bylaws of the Registrant (filed as Exhibit 3.1)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
|              | 
|4.1(5)        |  | Specimen certificate for share of common stock (filed as Exhibit 4.1)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
|              | 
|4.2(6)        |  | Rights Agreement, dated as of July 27, 2001, by and between the Registrant and American Stock Transfer & Trust Company, which includes the form of Certificate of Designation
setting forth the terms of the Series A Junior Participating Preferred Stock, $0.001 par value, as Exhibit A, the form of rights certificate as Exhibit B and the summary of rights to purchase Series A Junior Participating Preferred Stock as Exhibit
C. Pursuant to the Rights Agreement, printed rights certificates will not be mailed until after the Distribution Date (as defined in the Rights Agreement) (filed as Exhibit 4.1)
|              | 
|4.3(3)        |  | First Amendment to Rights Agreement by and between the Registrant and American Stock Transfer & Trust Company, as rights agent, dated as of March 31, 2003 (filed as Exhibit
10.3)                                                                                                                                                                                                                                                                                                                                                                                                                                      
|              | 
|10.1(7)     |  | 1995 Stock Incentive Plan, as amended, including form of stock option certificate for incentive and non-statutory stock options (filed as Exhibit 10.1)                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
|              | 
|10.2(7)     |  | 2000 Employee, Director, Consultant Stock Plan, including form of stock option agreement for non-statutory and incentive stock options (filed as Exhibit 10.2)                                                                                                                                                                                                                                                                                                                                                                                                                                                          
|              | 
|10.3(8)     |  | Amended and Restated 2005 Stock Plan and the form of stock option agreement for non-statutory and incentive stock options (filed as Exhibits 99.1, 99.2 and 99.3,
respectively)                                                                                                                                                                                                                                                                                                                                                                                                                                         



67



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|              |  |                                                                                                                                                                                                                                
|------------- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|ExhibitNumber |  | Description                                                                                                                                                                                                                    
|              | 
|10.4(7)     |  | Executive Benefit Program, including Executive Deferred Compensation Plan and Executive Severance Plan (filed as Exhibit 10.3)                                                                                                 
|              | 
|10.5(9)     |  | Lifecodes Corporation 1992 Employee Stock Option Plan (filed as Exhibit 99.2)                                                                                                                                                  
|              | 
|10.6(9)     |  | Lifecodes Corporation 1995 Employee Stock Option Plan (filed as Exhibit 99.3)                                                                                                                                                  
|              | 
|10.7(9)     |  | Lifecodes Corporation 1998 Stock Plan (filed as Exhibit 99.4)                                                                                                                                                                  
|              | 
|10.8(10)     |  | Commercial Services Agreement effective September 17, 2001 between the Registrant and the Department of Environment, Food and Rural Affairs (filed as Exhibit 10.22)                                                           
|              | 
|10.9(10)     |  | Amended Patent Assignment and License Agreement dated July 7, 2003 by and between the Registrant, GeneCo Pty Ltd, Diatech Pty Ltd and Queensland University of Technology (filed as
Exhibit 10.25)                             
|              | 
|10.10(10)    |  | Exclusive Patent License Agreement dated October 1, 2003 between the Registrant and Saint Louis University (filed as Exhibit 10.26)                                                                                            
|              | 
|10.11(10)    |  | Settlement Agreement dated August 6, 2002 between the Registrant and Saint Louis University (filed as Exhibit 10.27)                                                                                                           
|              | 
|10.12(10)     |  | Amendment No. 1 to Settlement Agreement dated October 1, 2003 between the Registrant and Saint Louis University (filed as Exhibit 10.28)                                                                                       
|              | 
|10.13(11)   |  | Director Compensation Policy, effective January 1, 2004 (filed as Exhibit 10.18)                                                                                                                                               
|              | 
|10.14(12)     |  | NWI Lease Agreement between the Registrant and NWI Warehouse Group L.P. dated February 15, 1996 for the facility located at 1400 Donelson Pike, Suite A-15, Nashville,
Tennessee, 37217 (filed as Exhibit 10.1)                
|              | 
|10.15(12)     |  | Lease Agreement Amendment No. 1 between the Registrant and Duke-Weeks Realty L.P. dated January 23, 2001 for the facility located at 1400 Donelson Pike, Suite A-15, Nashville,
Tennessee, 37217 (filed as Exhibit 10.2)       
|              | 
|10.16(12)     |  | Lease Agreement Amendment No. 2 between the Registrant and Duke Realty Limited Partnership dated August 8, 2005 for the facility located at 1400 Donelson Pike, Suite A-15,
Nashville, Tennessee, 37217 (filed as Exhibit 10.3)
|              | 
|10.17(12)     |  | Lease Agreement between the Registrant and Valwood Service Center I, Ltd. effective October 15, 2005 for the facility located at 13988 Diplomat Drive, Suite 100, Farmers Branch,
Texas, 75234 (filed as Exhibit 10.4)         
|              | 
|10.18(12)     |  | Lease Agreement between the Registrant and Valwood Service Center I, Ltd. effective December 15, 2005 for the facility located at 13988 Diplomat Drive, Suite 100, Farmers Branch,
Texas, 75234 (filed as Exhibit 10.5)        
|              | 
|10.19(13)   |  | Employment Agreement dated March 8, 2006 between the Registrant and Thomas A. Bologna (filed as Exhibit 99.1)                                                                                                                  
|              | 
|10.20(14)     |  | Letter Agreement by and between College Road Associates, Limited Partnership and the Registrant, dated January 18, 2005 (filed as Exhibit 10.27)                                                                               
|              | 
|10.21(14)     |  | Amendment No. 1 to Lease Agreement by and between Bellemead Development Corporation and the Registrant, dated November 1, 2005 (filed as Exhibit 10.28)                                                                        
|              | 
|10.22(14)    |  | Letter Agreement and Product Loan Agreement between the Registrant and Applied Biosystems, dated January 5, 2006 (filed as Exhibit
10.30)                                                                                      



68



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|              |  |                                                                                                                                                                                                  
|------------- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|ExhibitNumber |  | Description                                                                                                                                                                                      
|              | 
|10.23(15)   |  | Addendum to Employment Agreement dated December 8, 2006 between the Registrant and Thomas A. Bologna (filed as Exhibit 10.33)                                                                    
|              | 
|10.24(11)   |  | Employment Agreement dated as of October 5, 2007 between the Registrant and James F. Smith (filed as Exhibit 10.31)                                                                              
|              | 
|10.25(11)   |  | Employment Agreement dated as of November 19, 2007 between the Registrant and William J. Thomas (filed as Exhibit 10.33)                                                                         
|              | 
|10.26(16)   |  | Employment Agreement dated as of May 13, 2008 between the Registrant and Jeffrey S. Boschwitz (filed as Exhibit 10.1)                                                                            
|              | 
|10.27(17)     |  | Lease Agreement dated December 15, 2009 between Duft Enterprises Corp. and the Registrant for the facility located at 635 Columbia St., New Westminster, British Columbia(filed as
Exhibit 10.27)
|              | 
|10.28       |  | Executive Compensation Program (filed herewith)                                                                                                                                                  
|              | 
|21.1          |  | Subsidiaries of the Registrant (filed herewith)                                                                                                                                                  
|              | 
|23.1          |  | Consent of Grant Thornton LLP                                                                                                                                                                    
|              | 
|31.1          |  | Certification of Principal Executive Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002                                                                                           
|              | 
|31.2          |  | Certification of Principal Financial and Accounting Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002                                                                            
|              | 
|32.1          |  | Certifications of Principal Executive Officer and Principal Financial and Accounting Officer pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.                                          
|              | 
|99.1(18)      |  | Settlement Agreement dated September 3, 2010 between the Registrant and Accipiter Capital Management, LLC (filed as Exhibit 10.1)                                                                



| | Portions of this Exhibit were omitted and have been filed separately with the Secretary of the SEC pursuant to the Registrants application requesting confidential
treatment thereof.
|- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | Management or compensatory plan.
|-- | --------------------------------

|(1) | Previously filed with the SEC as Exhibits to, and incorporated herein by reference from, the Registrants Quarterly Report on Form 10-Q for the period ended
June 30, 2002 as filed with the SEC on August 14, 2002 (File No. 000-30267).
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | Previously filed with the SEC as Exhibits to, and incorporated herein by reference from, the Registrants registration statement on Form S-8 as filed with the SEC
on June 29, 2005 (File No. 333-126227).
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(3) | Previously filed with the SEC as Exhibits to, and incorporated herein by reference from, the Registrants Current Report on Form 8-K as filed with the SEC on
April 2, 2003 (File No. 000-30267).
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(4) | Previously filed with the SEC as an Exhibit to, and incorporated herein by reference from, the Registrants Current Report on Form 8-K as filed with the SEC on
September 7, 2007 (File No. 000-30267).
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(5) | Previously filed with the SEC as an Exhibit to, and incorporated herein by reference from, the Registrants Quarterly Report on Form 10-Q for the period ended
September 30, 2001 as filed with the SEC on November 14, 2001 (File No. 000-30267).
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(6) | Previously filed with the SEC as an Exhibit to, and incorporated herein by reference from, the Registrants registration statement on Form 8-A as filed with the
SEC on August 3, 2001 (File No. 000-30267).
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(7) | Previously filed with the SEC as Exhibits to, and incorporated herein by reference from, the Registrants registration statement on Form S-1, as amended, as
originally filed with the SEC on February 18, 2000 (File No. 333-30774).
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(8) | Previously filed with the SEC as Exhibits to, and incorporated herein by reference from, the Registrants Current Report on Form 8-K as filed with the SEC on
June 14, 2005 (File No. 000-30267).
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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|(9) | Previously filed with the SEC as Exhibits to, and incorporated herein by reference from, the Registrants registration statement on Form S-8 as filed with the SEC
on January 15, 2002 (File No. 333-76744).
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(10) | Previously filed with the SEC as an Exhibit to, and incorporated herein by reference from, the Registrants Annual Report on Form 10-K for the year ended
December 31, 2003 as filed with the SEC on March 29, 2004, as amended (File No. 000-30267).
|---- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(11) | Previously filed with the SEC as Exhibits to, and incorporated herein by reference from, the Registrants Annual Report on Form 10-K for the year ended
December 31, 2007 as filed with the SEC on March 12, 2008 (File No. 000-30267).
|---- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(12) | Previously filed with the SEC as Exhibits to, and incorporated herein by reference from, the Registrants Quarterly Report on Form 10-Q for the period ended
September 30, 2005 as filed with the SEC on November 9, 2005 (File No. 000-30267).
|---- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(13) | Previously filed with the SEC as an Exhibit to, and incorporated herein by reference from, the Registrants Current Report on Form 8-K as filed with the SEC on
March 9, 2006 (File No. 000-30267).
|---- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(14) | Previously filed with the SEC as Exhibits to, and incorporated herein by reference from, the Registrants Annual Report on Form 10-K for the year ended
December 31, 2005 as filed with the SEC on May 24, 2006 (File No. 000-30267).
|---- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(15) | Previously filed with the SEC as Exhibits to, and incorporated herein by reference from, the Registrants Annual Report on Form 10-K for the year ended
December 31, 2006 as filed with the SEC on March 15, 2007 (File No. 000-30267).
|---- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(16) | Previously filed with the SEC as an Exhibit to, and incorporated herein by reference from, the Registrants Quarterly Report on Form 10-Q for the period ended
June 30, 2008 as filed with the SEC on August 1, 2008 (File No. 000-30267).
|---- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(17) | Previously filed with the SEC as an Exhibit to, and incorporated herein by reference from, the Registrants Annual Report on Form 10-K for the year ended
December 31, 2009 as filed with the SEC on March 17, 2010, as amended (File No. 000-30267).
|---- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(18) | Previously filed with the SEC as Exhibits to, and incorporated herein by reference from, the Registrants Current Report on Form 8-K as filed with the SEC on
September 8, 2010 (File No. 000-30267).
|---- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this
report to be signed on its behalf by the undersigned, thereunto duly authorized.





|                     |  |  |  |                      |  |                                                                                      
|-------------------- |  |  |  | -------------------- |  | -------------------------------------------------------------------------------------
|                     |  |  |  | ORCHID CELLMARK INC.
|                     |  |  | 
|Date: March 15, 2011 |  |  |  | By:                  |  | /s/    THOMAS A.
BOLOGNA                                                             
|                     |  |  |  |                      |  | Thomas A. Bologna President and Chief Executive Officer (Principal Executive
Officer)

Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been
signed below by the following persons on behalf of the registrant and in the capacities indicated below and on the dates indicated.



|    |  |                                                |  |                                                                                         |  |               
|--- |  | ---------------------------------------------- |  | --------------------------------------------------------------------------------------- |  | --------------
|    |  | Signatures                                     |  | Title                                                                                   |  | Date          
|    |  |                                                | 
|By: |  | /s/    THOMAS A.
BOLOGNA Thomas A. Bologna     |  | President and Chief ExecutiveOfficer (Principal ExecutiveOfficer)                       |  | March 15, 2011
|    |  |                                                | 
|By: |  | /s/    JAMES F.
SMITH James F. Smith           |  | Vice President and Chief Financial Officer (Principal Financial and Accounting Officer) |  | March 15, 2011
|    |  |                                                | 
|By: |  | /s/    EUGENE I.
DAVIS Eugene I. Davis         |  | Chairman of the Board                                                                   |  | March 15, 2011
|    |  |                                                | 
|By: |  | /s/    JAMES
HART PH.D. James Hart
Ph.D.       |  | Director                                                                                |  | March 15, 2011
|    |  |                                                | 
|By: |  | /s/    BRUCE D.
DALZIEL Bruce D. Dalziel       |  | Director                                                                                |  | March 15, 2011
|    |  |                                                | 
|By: |  | /s/    STEFAN D. LOREN
PHD Stefan D. Loren PhD |  | Director                                                                                |  | March 15, 2011
|    |  |                                                | 
|By: |  | /s/    NICOLE S.
WILLIAMS Nicole S. Williams   |  | Director                                                                                |  | March 15, 2011



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Schedule II

ORCHID CELLMARK INC. AND SUBSIDIARIES

Valuation and Qualifying Accounts

Years ended December 31, 2010, 2009 and 2008

(In thousands)



|                                |  |                              |     |  |                             |   |     |                |  |   |                         |  |  |   |     | 
|------------------------------- |  | ---------------------------- | --- |  | --------------------------- | - | --- | -------------- |  | - | ----------------------- |  |  | - | --- | 
|Column A                        |  | Column B                     |     |  | Column D                    |   |     | Column E       |  |   | Balance atend of period | 
|Description                     |  | Balance atbeginningof period |     |  | Charged tocosts andexpenses |   |     | Deductions (1) |  |  
|2010                            |  |                              |     |  |                             |   |     |                |  |   |                         |  |  |   |     | 
|Allowance for doubtful accounts |  | $                            | 397 |  |                             | $ | 165 |                |  | $ | 122                     |  |  | $ | 440 | 
|                                |  |                              |     |  |                             |   |     |                |  |   |                         |  |  |   |     | 
|2009                            |  |                              |     |  |                             |   |     |                |  |   |                         |  |  |   |     | 
|Allowance for doubtful accounts |  | $                            | 533 |  |                             | $ | 188 |                |  | $ | 324                     |  |  | $ | 397 | 
|                                |  |                              |     |  |                             |   |     |                |  |   |                         |  |  |   |     | 
|2008                            |  |                              |     |  |                             |   |     |                |  |   |                         |  |  |   |     | 
|Allowance for doubtful accounts |  | $                            | 799 |  |                             | $ | (36 | )              |  | $ | 230                     |  |  | $ | 533 | 
|                                |  |                              |     |  |                             |   |     |                |  |   |                         |  |  |   |     | 



|(1) | Deductions primarily consist of accounts receivable write-offs and reserve adjustments.
|--- | ---------------------------------------------------------------------------------------



72