Exhibit 10.48

 

	
Confidential   Treatment Requested

Under 17 C.F.R.   §§ 200.80(b)(4) and
   240.24b-2
    	

    


 

CHANGE ORDER

 

AMENDED LETTER OF PAYMENT AUTHORIZATION

 

Amendment No. 01

 

September 10, 2012

 

Gary Hattersley, Ph.D.

Vice President, Biology

RADIUS HEALTH, INC.

6th Floor

201 Broadway

Cambridge, MA 02139

United States

ghattersley@radiuspharm.com

 

	
RE:
    	
STUDY   PN 670646
    (Radius No:10RAD029)
    	
Study   Title: A 12-Month Osteoporosis Intervention Study   BA058 by Subcutaneous Injection in the Ovariectomized Sprague Dawley Rats
    
	
 
    	
 
    	
 
    
	
 
    	
As   per Protocol Amendment # 1 dated: April 28, 2011

As   per Protocol Amendment # 2 dated: July 26, 2011

As   per Protocol Amendment # 4 dated: October 20, 2012

As   per Protocol Amendment # 6 dated: July 26, 2012
    
	
 
    	
 
    
	
 
    	
STUDY   START: May 2011
    


 

Dear Gary,

 

This communication is to serve as an Amended Letter of Payment Authorization (ALOPA) for the above referenced study, which will be performed at Charles River Laboratories Preclinical Services as set forth below.  Charles River Laboratories Preclinical Services shall perform these services in accordance with the existing Service Agreement executed between Charles River Laboratories Preclinical Services and RADIUS HEALTH, INC. Once fully executed, this ALOPA shall be incorporated into and made part of the existing Service Agreement.

 

Summary of Changes:

 

·Slide preparation and evaluation

·Statistics added

 

The price of this Protocol Amendment is as follows:

 

	
 
    	
Authorized   Price
    	
 
    	
$ [*]
    
	
 
    	
(after   discount)
    	
 
    	
(as   per signed ALOPA dated: February 1, 2011)
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Additional   Charge
    	
 
    	
$ [*]
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Additional   Charge:
    	
 
    	
 
    
	
 
    	
(with   [*]% + [*]% discounts)
    	
 
    	
$ [*]
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Revised   Price
    	
 
    	
$ 1,081,896 US
    


 

 




[*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

 

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The payment schedules of this study are as follows:

 

·$ [*] [15%]   Due at animal arrival — (Paid)

·$ [*] [75%]   Equal Monthly Installment — (Invoiced and paid)

·$ [*] Additional Charge   Due upon receipt of invoice — (ALOPA1)

·$ [*] [75%]   Equal Monthly Installment

·$ [*] [5%]  Due upon Submission of Draft Report

·$ [*] [5%] Due upon Submission of Final Report

 

Please sign and return this document via facsimile or email (contact information below).  Should you have any questions or require any additional information, please do not hesitate to call me.  We look forward to being of service.

 

Best regards,

 

	
/s/   Stéphane Besner
    	
 
    	
/s/   Gary Hattersley
    
	
 
    	
 
    	
Authorized   Sponsor Representative
    
	
Stéphane   Besner, B.Sc. M.B.A
    	
 
    	
 
    
	
Senior   Client Manager, Sales & Marketing
    	
 
    	
Gary   Hattersley, SVP Preclinical Development 
    
	
Charles River Laboratoires
    	
 
    	
Print   (Name and Title)
    
	
Preclinical Services Montreal Inc.
    	
 
    	
 
    
	
22022 Transcanadienne
    	
 
    	
September 14,   2012
    
	
Senneville, Québec, Canada H9X 3R3
    	
 
    	
Date
    
	
Tel:   (514) 630-2436 Fax: (514) 630-8230
    	
 
    	
 
    
	
e-mail:stephane.besner@crl.com
    	
 
    	
 
    
	
Web   site: www.criver.com
    	
 
    	
 
    


 

 

If a PO is required, please submit PO with Letter of Payment Authorization or fax to 514-630-8230.

 

c.c. S. Pryce, D. Tremblay, S Y. Smith, E. Lesage

CRT: 24056

E:\CLIENTS\Radius\2012\670646.L7(ALOPA1) 10Sep12.doc

O6UJ9 - A0013JF

 




[*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

 

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