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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549





FORM 10-K/A

AMENDMENT NO. 1





(Mark One)

|x | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ------------------------------------------------------------------------------------

For the fiscal year ended December 31, 2010



| ̈ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------

For the transition period from              to

Commission file number: 000-30267





ORCHID CELLMARK INC.

(Exact name of registrant as specified in its charter)







|                                                               |  |                                     
|-------------------------------------------------------------- |  | ------------------------------------
|Delaware                                                       |  | 22-3392819                          
|(State or other jurisdiction of
incorporation or organization) |  | (I.R.S. Employer Identification No.)
|                                                               | 
|4390 US Route One, Princeton, NJ                               |  | 08540                               
|(Address of principal executive offices)                       |  | (Zip code)                          

Registrants telephone number, including area code: (609) 750-2200





Securities registered pursuant to Section 12(b) of the Exchange Act:



|                                        |  |                                          
|--------------------------------------- |  | -----------------------------------------
|Title of each class                     |  | Name of each exchange on which registered
|                                        | 
|Common Stock, $.001 Par Value Per Share |  | The NASDAQ Stock Market LLC              
|                                        | 
|Preferred Share Purchase Rights         |  | The NASDAQ Stock Market LLC              

Securities registered pursuant to Section 12(g) of the Exchange Act:

None





Indicate by
check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.    Yes   ̈    No  x

Indicate by check mark if the registrant is not required to file reports pursuant
to Section 13 or Section 15(d) of the Exchange Act.    Yes   ̈    No  x

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the
Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90
days.    Yes  x    No   ̈

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every
Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such
files).    Yes   ̈    No   ̈

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and will
not be contained, to the best of registrants knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment to this Form
10-K.  x

Indicate by check mark whether the registrant is a large
accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See definitions of large accelerated filer, accelerated filer and smaller reporting company in Rule 12b-2 of the
Exchange Act. (Check one):



|                        |  |                                                  |  |                           |  |  
|----------------------- |  | ------------------------------------------------ |  | ------------------------- |  | -
|Large accelerated filer |  |  ̈                                                |  | Accelerated filer         |  |  ̈
|                        |  |                                                  | 
|Non-accelerated filer   |  |  ̈  (do not check if a smaller reporting company) |  | Smaller reporting company |  | x

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange
Act)    Yes   ̈    No  x

The aggregate market value of the registrants common stock held by non-affiliates of the registrant (without admitting that any
person whose shares are not included in such calculation is an affiliate) computed by reference to the price at which the common stock was last sold as of the last business day of the registrants most recently completed second fiscal quarter
was approximately $37,451,577.

As of April 25, 2011, the registrant had 29,992,186 shares of common stock outstanding.





DOCUMENTS INCORPORATED BY REFERENCE

None.









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EXPLANATORY NOTE

The purpose of this Amendment No. 1 (the Amendment) to the Annual Report on Form 10-K of Orchid Cellmark Inc. (the
Registrant) for the year ended December 31, 2010 as filed on March 15, 2011 (the Original Form 10-K) is to include the disclosure required in Part III, Items 10, 11, 12, 13 and 14. Except for Items 10, 11, 12, 13
and 14 of Part III and Item 15(3) of Part IV, no other information included in the Original Form 10-K is amended or changed by this Amendment.

On April 5, 2011, the Registrant entered into an Agreement and Plan of Merger (the Merger Agreement), with Laboratory Corporation of America Holdings, a Delaware corporation
(LabCorp), and OCM Acquisition Corp., a Delaware corporation and a wholly owned subsidiary of LabCorp (Purchaser), pursuant to which LabCorp will acquire the Registrant in a two-step transaction. Pursuant to the Merger
Agreement, and subject to its terms and conditions, on April 19, 2011, Purchaser commenced a cash tender offer to purchase all outstanding shares of the Registrants common stock, par value $0.001 per share (the Common Stock),
including, to the extent outstanding, the associated preferred stock purchase rights (the Rights) issued under the Rights Agreement, dated July 27, 2001, as amended, between the Registrant and American Stock Transfer &
Trust Company, as rights agent (such Rights, to the extent outstanding, together with the shares of the Common Stock, the Shares), at a purchase price of $2.80 per share, net to the seller in cash, without interest thereon and subject to
any required tax withholding.

Unless extended, the tender offer is currently scheduled to expire at 5:00 p.m., New York City
time, on Tuesday, May 17, 2011, after which time, if all conditions to the tender offer have been satisfied or waived, Purchaser will accept for payment all Shares validly tendered pursuant to the offer and not validly withdrawn. If successful,
the tender offer will be followed by the merger of Purchaser into the Registrant, with the Registrant being the surviving corporation and becoming a wholly owned subsidiary of LabCorp. In the merger, Shares not purchased in the tender offer (other
than Shares held by stockholders who properly demand and perfect their appraisal rights under Delaware law) will be converted into the right to receive the same $2.80 per share cash payment, without interest, paid in the tender offer.



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ORCHID CELLMARK INC.

FORM 10-K/A

INDEX



|           |  |                                                                                                |    |      |    | 
|---------- |  | ---------------------------------------------------------------------------------------------- | -- | ---- | -- | 
|           |  |                                                                                                |    | Page |   
|           |  | PART III                                                                                       |    |      |    | 
|ITEM 10.   |  | DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE                                         |    |      | 4  | 
|ITEM 11.   |  | EXECUTIVE COMPENSATION                                                                         |    |      | 13 | 
|ITEM 12.   |  | SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERS |    |      | 24 | 
|ITEM 13.   |  | CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE                      |    |      | 26 | 
|ITEM 14.   |  | PRINCIPAL ACCOUNTANT FEES AND SERVICES                                                         |    |      | 27 | 
|           |  |                                                                                               
|           |  | PART IV                                                                                        |    |      |    | 
|ITEM 15.   |  | EXHIBITS AND FINANCIAL STATEMENT SCHEDULES                                                     |    |      | 28 | 
|SIGNATURES |  |                                                                                                | 32 |     



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PART III



|Item 10. | DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE
|-------- | ------------------------------------------------------

Executive Officers and Directors

The following table sets forth certain
information, as of April 25, 2011, concerning our executive officers and directors:



|                            |  |     |  |                                                   
|--------------------------- |  | --- |  | --------------------------------------------------
|Name                        |  | Age |  | Position                                          
|Executive Officers          |  |     |  |                                                   
|Thomas A. Bologna           |  | 62  |  | President and Chief Executive Officer and Director
|Jeffrey S. Boschwitz, Ph.D. |  | 44  |  | Vice President, North America Marketing and Sales 
|James F. Smith              |  | 61  |  | Vice President and Chief Financial Officer        
|William J. Thomas           |  | 51  |  | Vice President and General Counsel                
|                            |  |    
|Non-Employee Directors      |  |     |  |                                                   
|Eugene I. Davis (1)(2)      |  | 56  |  | Chairman of the Board of Directors                
|Bruce D. Dalziel (1)(3)     |  | 53  |  | Director                                          
|James M. Hart, Ph.D (2)     |  | 63  |  | Director                                          
|Stefan Loren, Ph.D (1)(3)   |  | 47  |  | Director                                          
|Nicole S. Williams (2)(3)   |  | 66  |  | Director                                          



|(1) | Member of our Compensation Committee. Mr. Dalziel is the Chairman of the committee.
|--- | -----------------------------------------------------------------------------------

|(2) | Member of our Nominating and Governance Committee. Mr. Davis is the Chairman of the committee.
|--- | ----------------------------------------------------------------------------------------------

|(3) | Member of our Audit Committee. Ms. Williams is the Chairperson of the committee.
|--- | --------------------------------------------------------------------------------

Biographical information regarding each of our directors and executive officers is as follows. The following paragraphs also include
specific information about each directors experience, qualifications, attributes or skills that led the Board of Directors to the conclusion that the individual should serve on the Board of Directors as of the time of this filing, in light of
our business and structure.

Executive Officers

Thomas A. Bolognahas served as our President and Chief Executive Officer and a member of our Board of Directors since April 2006. From 2004 to 2005, Mr. Bologna was Chief Executive Officer,
President and a director of Quorex Pharmaceuticals, Inc. a pre-clinical stage anti-infective company. Mr. Bologna was Chief Executive Officer, President and a director of Ostex International, Inc. which developed, manufactured and marketed
innovative products for the management of osteoporosis, from 1997 to 2003, and in 1999 he was also appointed Chairman of the Board. From 1996 to 1997, Mr. Bologna was a principal at Healthcare Venture Associates, a consulting firm. From 1994 to
1996, Mr. Bologna was Chief Executive Officer, President and a director of Scriptgen Pharmaceuticals, Inc., a biotechnology company with proprietary drug screening technology that developed orally active drugs to regulate gene expression, and
from 1987 to 1994, Mr. Bologna was Chief Executive Officer, President and a director of Gen-Probe Incorporated, a biotechnology company commercializing genetic-probe-based technology for diagnostic and therapeutic applications, and in 1992 he
was also appointed Chairman of the Board. Prior to Gen-Probe, Mr. Bologna held several senior level positions with Becton, Dickinson and Company and Warner-Lambert Company. At Becton, Dickinson and Company, he served as President of the
Diagnostic Instrument Systems Division, President of the Johnston Laboratories Division, and Vice President and General Manager of the Hynson, Wescott & Dunning biotechnology unit. At Warner-Lambert Company, he served as a Vice President
responsible for the marketing, sales and research and development functions, as well as the Asia/Pacific profit center for the Scientific Instrument Division. Mr. Bologna currently serves as Chairman of the Board of Strategic Diagnostics Inc.,
a biotechnology company, and is a member of the Board of Directors of Aperio Technologies. Mr. Bologna received an M.B.A. and a B.S. from New York University.

Jeffrey S. Boschwitz, Ph.D., has served as our Vice President, North America Marketing and Sales since May 2008. Dr. Boschwitz has over 12 years experience in the diagnostics and
pharmaceutical industries. Before joining us, he was Director of Marketing Planning and Analysis at Quest Diagnostics where he was responsible for development of the physician business marketing plan and optimizing sales force effectiveness of plan
execution. Previously, Dr. Boschwitz was a Principal in Booz Allen Hamiltons health care practice with a focus on growth and operations projects for the diagnostics and pharmaceutical industries. Earlier in his career, he was a Project
Manager for Plan A Consulting where he led projects to optimize the value of pharmaceutical and biotechnology company new product pipelines. Dr. Boschwitz received a B.S. in Biology and Ph.D. in Immunology from Cornell University and completed
his Post-Doctoral work at Stanford University.



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James F. Smith has served as our Vice President and Chief Financial Officer since
October 2007. Mr. Smith was most recently Executive Vice President and Chief Financial Officer of Aphton Corporation, a biotechnology company that developed cancer immunotherapies, from August 2004 to 2007. Prior to joining Aphton, he served as
Vice President and Global Controller of Ansell (Healthcare) Ltd., a manufacturer of healthcare-related barrier protection products, from 2001 to 2004. Prior to that, Mr. Smith held senior finance/accounting positions for Wyeth and American
Cyanamid Company. After graduating from Quinnipiac University with a degree in accounting, Mr. Smith started his accounting career at PricewaterhouseCoopers. He is licensed as a certified public accountant.

William J. Thomas has served as our Vice President and General Counsel since November 2007. Mr. Thomas was formerly Senior
Vice President and General Counsel for Cytogen Corporation, a specialty pharmaceutical company that commercialized oncology products, from August 2004 to November 2007. Prior to joining Cytogen, Mr. Thomas was a senior partner with the law firm
of Wilmer Cutler Pickering Hale and Dorr LLP from January 2000 to August 2004. Previously, he was a partner at the law firm Buchanan Ingersoll P.C. Mr. Thomas has more than 20 years of experience in the areas of general corporate issues, public
offerings, mergers and acquisitions, securities law compliance, licensing and managing intellectual property. Mr. Thomas received a J.D. degree from Fordham University School of Law and a B.A. degree in Political Science from Rutgers
University.

Directors

Eugene I. Davisis Chairman and Chief Executive Officer of PIRINATE Consulting Group, LLC, or PIRINATE, a privately held consulting firm specializing in turnaround management, merger and
acquisition consulting and hostile and friendly takeovers, proxy contests and strategic planning advisory services for domestic and international public and private business entities. Since forming PIRINATE in 1997, Mr. Davis has advised,
managed, sold, liquidated and served as a Chief Executive Officer, Chief Restructuring Officer, Director, Committee Chairman and Chairman of the Board of a number of businesses operating in diverse sectors such as telecommunications, automotive,
manufacturing, high-technology, medical technologies, metals, energy, financial services, consumer products and services, import-export, mining and transportation and logistics. Previously, Mr. Davis served as President, Vice Chairman and
Director of Emerson Radio Corporation and Chief Executive Officer and Vice Chairman of Sport Supply Group, Inc. He began his career as an attorney and international negotiator with Exxon Corporation and Standard Oil Company (Indiana) and as a
partner in two Texas-based law firms, where he specialized in corporate/securities law, international transactions and restructuring advisory services. Mr. Davis holds a bachelors degree from Columbia College, a master of international
affairs degree (MIA) in international law and organization from the School of International Affairs of Columbia University, and a Juris Doctorate from Columbia University School of Law. Mr. Davis is also a member of the Board of Directors of
Atlas Air Worldwide Holdings, Inc., Knology, Inc., DEX One Corp., Ambassadors International Inc., Rural/Metro Corp, Spectrum Brands, Inc. and TerreStar Corporation.

The Board of Directors has concluded that Mr. Davis is qualified to serve as a member of the Board of Directors based upon his extensive experience serving on the board of directors of a wide-range
of public companies, as chairman in certain instances, and his experience as the chief executive officer of several companies. As a result of these and other professional experiences, coupled with his strong leadership qualities, Mr. Davis
possesses particular knowledge and experience in the areas of strategic planning, mergers and acquisitions, finance, accounting, capital structure and board practices of other corporations.

For information concerning the arrangement pursuant to which Mr. Davis was elected to the Board of Directors, see the disclosure
below under the heading Nominations for Director.

Thomas A. Bologna, see biographical information above.

The Board of Directors has concluded that Mr. Bologna is qualified to serve as a member of the Board of Directors based
upon his experience in the DNA diagnostic market, experience with operations and with mergers and acquisitions and his prior experience as the chief executive officer and chairman of the board of multiple public and private companies.

Bruce D. Dalziel, has served as a member of our Board of Directors since April 2010. Mr. Dalziel currently serves as Chief
Financial Officer and Executive Vice President, Compliance, for Medidata Solutions, a clinical development technology company with global operations, where he leads all aspects of finance, including control, financial reporting, tax, treasury,
mergers and acquisitions, and internal audit, as well as legal, risk management, investor relations, regulatory policy and compliance. From August 2005 to August 2007, he was Chief Financial Officer for BISYS Inc. an outsourcing provider to the
financial services industry. From September 2000 to July 2005, he was Chief Financial Officer for DoubleClick, a



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global internet advertising solutions company. Earlier in his career, Mr. Dalziel held an array of finance positions with Prudential Life Insurance, rising to Corporate Vice President,
Financial Planning and Analysis. A 1992 graduate of Columbia Universitys Executive MBA Program, he earned bachelor degrees from both Georgia Tech and Ursinus College.

The Board of Directors has concluded that Mr. Dalziel is qualified to serve as a member of the Board of Directors based upon his financial expertise, experience with operations and his experience of
an executive officer with publicly held companies. Mr. Dalziel also has significant strategic and investment experience.

James M. Hart, Ph.D., has served as a member of our Board of Directors since January 2010. Dr. Hart is the former
Commissioner of the City of London Police Force with a career spanning almost four decades in various U.K police forces. His experience included senior operational and command positions at the Metropolitan Police, New Scotland Yard and the Surrey
Police force. He also was Chairman of the Association of Chief Police Officers Economic Crime Portfolio, headed the Commissioners Policy Unit at New Scotland Yard and was a member of the senior team that implemented the restructuring of the
Metropolitan Police Force, the U.K.s largest law enforcement agency. Dr. Hart is currently a non-executive director of the Office of Fair Trading in the U.K., an independent competition and consumer protection authority, and Knightsbridge
Guarding Ltd, a security company, and Chairman of Radio Tactics Ltd., a software engineering company. Dr. Hart holds a B.Sc. (Hons) degree in Systems Science and Management, and a PhD degree in Systems Science, both from the City University,
London, and is a Fellow of the Chartered Management Institute. He was awarded the Queens Police Medal in the 1999 Queens Birthday Honors list and the CBE (Commander of the Order of the British Empire) in 2006.

The Board of Directors has concluded that Dr. Hart is qualified to serve as a member of the Board of Directors based upon his
experience in law enforcement and experience with operational matters. Dr. Hart also has experience with forensic operations in the U.K. which is valuable in supporting our U.K. business and translating certain best practices to our U.S.
operations.

Stefan Loren, Ph.D., has served as a Managing Director of Westwicke Partners, LLC, or Westwicke, a
strategic capital markets advisory firm that provides customized investor relations programs and independent capital markets advice to small and mid-cap health care companies, since July 2008. Prior to joining Westwicke, Dr. Loren served as a
senior research analyst at Perceptive Advisors, LLC from May 2007 to July 2008. From August 2005 to May 2007, Dr. Loren served as a senior equity research analyst and portfolio manager at MTB Investment Advisors. Dr. Loren served as a
managing director and health care specialist at Legg Mason, Inc. from August 2003 to August 2005. Dr. Loren is a director of PolyMedix, Inc. Dr. Loren earned a Ph.D. in Organic/Pharmaceutical Chemistry from the University of California,
Berkeley and a B.A. from the University of California, San Diego.

The Board of Directors has concluded that Dr. Loren is
qualified to serve as a member of the Board of Directors based upon his investment, business and scientific experience, in particular his experience as a sell-side and buy-side analyst in the biotechnology and related healthcare sectors and as a
research chemist.

For information concerning the arrangement pursuant to which Dr. Loren was elected to the Board of
Directors, see the disclosure below under the heading Nominations for Director.

Nicole S. Williams has
served as a member of our Board of Directors since 2002. Ms. Williams has 17 years experience as a chief financial officer of public and private global companies. Ms. Williams formerly was the Chief Financial Officer of Abraxis Bioscience
Inc., a biopharmaceutical company, and President of Abraxis Pharmaceutical Products, a division of Abraxis Bioscience Inc., positions she assumed upon the merger of American Pharmaceutical Partners, Inc. and American Bioscience Inc. in April 2006.
From 2002 to 2006, Ms. Williams was the Executive Vice President and Chief Financial Officer of American Pharmaceutical Partners and in December 2005, assumed additional responsibilities as President of American Pharmaceutical Partners.
Ms. Williams is the President of the Nicklin Capital Group, Inc., a firm she founded in 1999 to invest in and provide consulting to early stage technology companies in the Midwest. From 1992 to 1999, Ms. Williams was the Executive Vice
President, Chief Financial Officer and Corporate Secretary of R.P. Scherer Corporation in Troy, Michigan. She currently serves as a director of Progenics Pharmaceuticals, Inc. and Intercept Pharmaceuticals, Inc. She maintains a Certificate of
Director Education from the National Association of Corporate Directors which she earned in 2007. Ms. Williams received her Demi-License es Science Politique from the University of Geneva, Switzerland, her License es Science Politique from the
Graduate Institute of International Affairs, University of Geneva, Switzerland and her M.B.A. from the Graduate School of Business, University of Chicago.

The Board of Directors has concluded that Ms. Williams is qualified to serve as a member of the Board of Directors based upon her financial expertise, her experience with operations and her service
as a chief financial officer and board member with other companies. She brings expertise to the Company in the areas of financial analysis and reporting, internal auditing and controls, and risk management oversight. Her board and audit committee
roles at other public companies give her a broad perspective in the areas of financial reporting, and audit and Enterprise Risk Management. Her international training and experience with global corporations helps to guide the Company as its
operations and activities have become more international.



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CORPORATE GOVERNANCE

Board Leadership Structure

The roles of Chairman of the Board and Chief
Executive Officer have been split by our Board of Directors. In accordance with our amended and restated bylaws, our Board of Directors elects our Chairman and our Chief Executive Officer, and each of these positions may be held by the same person
or may be held by different people. The Board of Directors does not have a policy mandating that the roles of Chairman and Chief Executive Officer continue to be separated.

Board Role in Risk Oversight

Our Board of Directors oversees an
enterprise-wide approach to risk management, designed to support the achievement of organizational and strategic objectives, to improve long-term organizational performance and enhance stockholder value. A fundamental part of risk management is not
only understanding the risks a company faces and what steps management is taking to manage those risks, but also understanding what level of risk is appropriate for the company. The involvement of the full Board of Directors in understanding and
supporting the Companys business strategy is a key part of its assessment of the appropriate level of risk for the Company. In 2007, the Company initiated a formal enterprise risk management program (the ERM program) to identify,
evaluate, monitor and manage the key risks affecting the Company. The Audit Committee has been charged with the primary oversight of managements responsibility with respect to this program, and the Board of Directors has received periodic
reports from management and the Audit Committee Chair regarding the ERM program. The Board of Directors also oversees the operation of the Companys compliance program, including the application and enforcement of the Companys Corporate
Code of Business Conduct and Ethics that is targeted at principal areas of operational, ethical and legal risk for the Companys operations, and is applicable to all employees, officers and directors of the Company.

While the Board of Directors oversees the Companys enterprise-wide approach to risk management, various committees of the Board of
Directors also have responsibility for risk management. The Audit Committee, in connection with its quarterly and annual review of the Companys financial statements, receives reports from the Companys Chief Financial Officer and the
Companys independent registered public accounting firm regarding significant risks and exposures and will assess managements steps to minimize them. In setting compensation, the Compensation Committee reviews all compensation policies
and practices for all employees to determine whether such policies and practices create risks that are reasonably likely to have a material adverse effect on the Company and report any critical risks to the Board of Directors. As noted above, the
Companys Audit Committee continues to be engaged with management respecting the Companys ERM program and assisted with the identification of areas of high, medium and low risk. Areas classified as high risk include, but are not limited
to, the areas of competition, reliance on government contracts, government outsourcing trends, management of growth, managing the consolidation of facilities, building a new CODIS laboratory, and attracting and retaining key personnel. The ERM
program has been enhanced with the development of a formal, periodic reporting process with the Audit Committee which permits the on-going monitoring and reporting on new risks, changes in the classification of risks and the updating of management
action plans to address risks so as to provide updated, periodic reporting to the Board of Directors to assist them with their risk oversight responsibilities.



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The Board of Directors

Our Certificate of Incorporation and By-laws provide that our business is to be managed by or under the direction of our Board of Directors. Our Board of Directors is divided into three classes for
purposes of election. One class is elected at each annual meeting of stockholders to serve for a three-year term. Our Board of Directors currently consists of seven members, classified into three classes as follows:



| |  |  | The Class I directors are Mr. Davis and Dr. Loren, and their term will end at the 2013 annual meeting of stockholders;
| | - |  | ----------------------------------------------------------------------------------------------------------------------



| |  |  | The Class II directors are Mr. Bologna and Mr. Dalziel, and their term will end at the 2011 annual meeting of stockholders; and
| | - |  | -------------------------------------------------------------------------------------------------------------------------------



| |  |  | The Class III directors are Dr. Hart and Ms. Williams, and their term will end at the 2012 annual meeting of stockholders.
| | - |  | --------------------------------------------------------------------------------------------------------------------------

In the event of any increase or decrease in the authorized number of directors, (i) each director then
serving shall continue as a director of the class of which he or she is a member until the expiration of such directors current term or such directors prior death, retirement, removal or resignation and (ii) the newly created or
eliminated directorships resulting from such increase or decrease shall, if reasonably possible, be apportioned by the Board of Directors among the three classes of directors to ensure that no one class has more than one director more than any other
class. To the extent reasonably possible, consistent with the foregoing rule, any newly created directorships shall be added to those classes whose terms of office are to expire at the latest dates following such allocation and newly eliminated
directorships shall be subtracted from those classes whose terms of office are to expire at the earliest dates following such allocation, unless otherwise provided for from time to time by resolution adopted by a majority of the directors then in
office.

Meetings and Committees of the Board of Directors

Meeting Attendance

Each director is expected to devote sufficient time,
energy and attention to ensure diligent performance of his or her duties and to attend all Board, committee and stockholders meetings. During the fiscal year ended December 31, 2010, there were 15 meetings of our Board of Directors and
each director serving during 2010 attended at least 75% of the aggregate of Board meetings and meetings of committees on which he or she served. The Board of Directors has adopted a policy under which each member of the Board of Directors is
strongly encouraged to attend each annual meeting of stockholders. All but one of the directors serving as of November 9, 2010 attended the 2010 annual meeting of stockholders.

Committees of the Board of Directors

The Board of Directors has established an Audit Committee, a Compensation Committee and a Nominating and Governance Committee to facilitate and assist the Board of Directors in the execution of its
responsibilities. In accordance with the listing standards of the Nasdaq Stock Market LLC, these committees are comprised solely of non-employee, independent directors. Charters of the Audit Committee, Compensation Committee and Nominating and
Governance Committee are available on our website atwww.orchidcellmark.com by first clicking on the section for Investor Relations and then Corporate Governance. Committee charters are also available without charge,
to any stockholder, upon written request, to the Corporate Secretary at Orchid, 4390 US Route One, Princeton, New Jersey 08540. The table below shows current membership of each of the Audit Committee, the Compensation Committee and the Nominating
and Governance Committee of our Board of Directors:



|                    |  |                        |  |                                    
|------------------- |  | ---------------------- |  | -----------------------------------
|Audit Committee     |  | Compensation Committee |  | Nominating and Governance Committee
|                    |  |                       
|Bruce D. Dalziel    |  | Bruce D. Dalziel*      |  | Eugene Davis*                      
|                    |  |                       
|Stefan Loren        |  | Eugene Davis           |  | James M. Hart                      
|                    |  |                       
|Nicole S. Williams* |  | Stefan Loren           |  | Nicole S. Williams                 



|* | Committee Chairperson
|- | ---------------------

Audit
Committee.Our Audit Committee met seven times during fiscal 2010. Our Audit Committees role and responsibilities are set forth in a written charter and include the authority to retain and terminate the services of our independent
registered public accounting firm, review annual consolidated financial statements, consider matters relating to



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accounting policy and internal controls, review the scope of annual audits and oversee the Companys processes to assess and manage financial and enterprise risk. All members of the Audit
Committee satisfy the current independence standards promulgated by the SEC and by the Nasdaq Stock Market LLC, as such standards apply specifically to members of audit committees. Our Board of Directors has determined that Ms. Williams is an
audit committee financial expert, as the SEC has defined that term in Item 407 of Regulation S-K.

Compensation Committee. Our Compensation Committee met two times during fiscal 2010. Our Compensation Committees role and
responsibilities are set forth in a written charter and include the authority to review, approve and make recommendations regarding our compensation policies, practices and procedures to ensure that legal and fiduciary responsibilities of the Board
of Directors are carried out and that such policies, practices and procedures contribute to our success, and to review all compensation policies and practices for all employees to determine whether such policies and practices create risks that are
reasonably likely to have a material adverse effect on us and report any critical risks to the Audit Committee. The Compensation Committee is responsible for the determination of the compensation of our President and Chief Executive Officer, and
conducts its decision making process with respect to that issue without the President and Chief Executive Officer present. The Compensation Committee also determines the compensation of our other executive officers and our directors. All members of
the Compensation Committee satisfy the current independence standards promulgated by the SEC and by the Nasdaq Stock Market LLC, as such standards apply specifically to members of compensation committees.

Our Compensation Committee is charged with establishing a compensation policy for our executives and directors that is designed to
attract and retain the best possible executive talent, to motivate them to achieve corporate objectives, and reward them for superior performance. Our Compensation Committee is also responsible for establishing and administering our executive
compensation policies and equity compensation plans, including our Amended and Restated 2005 Stock Plan. The Compensation Committee meets at least two times per year and more often as necessary to review and make decisions with regard to executive
compensation matters. As part of its review of executive compensation matters, the Compensation Committee may delegate any of the powers given to it to a subcommittee of the Compensation Committee.

For purposes of determining executive compensation for our President and Chief Executive Officer in 2007, we engaged a consultant, Mercer
Human Resource Consulting, Inc., or Mercer, to prepare and analyze data and compare our compensation programs with the practices of a group of peer companies. In prior years, we also engaged a consultant to assist us in assessing the compensation of
our technical staff. We have not engaged a compensation consultant since 2007.

Nominating and Governance Committee.
Our Nominating and Governance Committee was formed in September 2010 and met one time during fiscal 2010. Our Nominating and Governance Committees role and responsibilities are set forth in a written charter and include the authority to
evaluate candidates and nominate persons to stand for election to the Board of Directors or fill vacancies on the Board of Directors or newly created directorships. In addition, the Nominating and Governance Committee (a) identifies candidates
to serve as directors and on committees of the Board of Directors, (b) annually reviews, for each director and nominee, the particular experience, qualifications, attributes or skills that contribute to the Board of Directors conclusion
that the person should serve or continue to serve as a director of the Company, (c) determines desired Board of Directors member skills and attributes and conducts searches for prospective directors whose skills and attributes reflect those
desired, and (d) considers bona fide candidates recommended by stockholders for nomination for election to the Board of Directors in accordance with procedures included in its charter.

See discussion below under the heading Nominations for Directors for more information.

Nominations for Director

In evaluating director nominees, the Nominating and Governance Committee considers the following factors:



| |  |  | integrity and ethical values;
| | - |  | -----------------------------



| |  |  | commitment to promoting and enhancing the long term value of the Company for its stockholders;
| | - |  | ----------------------------------------------------------------------------------------------



| |  |  | absence of conflicts of interest;
| | - |  | ---------------------------------



| |  |  | fair and equal representation of all stockholders of the Company without favoring or advancing any particular stockholder;
| | - |  | --------------------------------------------------------------------------------------------------------------------------



| |  |  | demonstrated achievement of the nominee;
| | - |  | ----------------------------------------



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| |  |  | sound judgment and demonstrated ability to function effectively in an oversight role;
| | - |  | -------------------------------------------------------------------------------------



| |  |  | diversity of the Board of Directors;
| | - |  | ------------------------------------



| |  |  | understanding of the Companys business;
| | - |  | ----------------------------------------



| |  |  | available time to devote to the Board of Directors and its committees.
| | - |  | ----------------------------------------------------------------------

Other than the foregoing, there are no minimum criteria for director nominees, although the Nominating and Governance Committee may
consider such other factors as it may deem are in the best interests of the Company and its stockholders. The Nominating and Governance Committee does not assign specific weights to, and a potential or incumbent director will not necessarily satisfy
all of, the foregoing criteria. In evaluating a candidate, the Nominating and Governance Committee does not distinguish on the basis of whether the candidate was recommended by a stockholder. The Nominating and Governance Committees charter
contains the diversity policy adopted by the Board of Directors. Under such policy, the Nominating and Governance Committee will consider issues of diversity in identifying and considering nominees for director, and will strive where appropriate to
achieve a diverse balance of backgrounds, perspectives, experience, age, gender, ethnicity and country of citizenship on the Board of Directors and its committees.

Our Nominating and Governance Committees charter contain provisions which address the process by which a
stockholder may nominate an individual to submit to the Nominating and Governance Committee recommendations for nomination to the Companys Board of Directors. This policy is set forth in the Companys Nominating and Governance Committee
charter, which is available on the Companys website at www.orchidcellmark.com by first clicking on the section for Investor Relations and then Corporate Governance. Under this policy, the Nominating and
Governance Committee considers director candidates recommended by stockholders who satisfy the notice, information and consent requirements set forth in the charter. To recommend a nominee for election to the Board of Directors, a stockholder must
submit his or her recommendation to the Corporate Secretary at the Companys principal executive offices at 4390 US Route One, Princeton, NJ 08540. A stockholders recommendation must be received by the Company (i) no later than one
hundred twenty (120) days prior to the first anniversary of the date of the previous years proxy statement for the annual meeting of stockholders, or (ii) in the event that the date of the annual meeting of stockholders for the
current year is more than thirty (30) days before or more than sixty (60) days after the anniversary date of the previous years annual meeting of stockholders, the submission of a recommendation by the stockholder will be considered
timely if it is delivered not earlier than the close of business on the ninetieth (90th) day prior to the annual meeting of stockholders for the current year and not later than the close of business on the later of the sixtieth
(60th) day prior to the annual meeting of
stockholders for the current year, or (iii) the close of business on the tenth (10th) day following the day on which the Company makes a public announcement of the date of the annual meeting of stockholders for the current year.

A stockholders recommendation must be accompanied by, among other things, the following information with respect to a
stockholder director nominee as specified in the Nominating and Governance Committees charter: (i) the name, age, business address and residence address of the recommended person, (ii) the principal occupation or employment of the
recommended person during the past five years, (iii) the class and number of shares of the Company stock beneficially owned by the recommended person on such date, (iv) any transactions between the Company and the proposed nominee in
excess of $120,000, (v) whether in the past ten years the recommended person has (1) filed for bankruptcy, (2) been convicted in a criminal proceeding or named subject of a criminal proceeding, (3) been found by any court of
competent jurisdiction to have violated any Federal law or Federal commodities law, and such judgment or finding has not been subsequently reversed, suspended or vacated or (4) been subject to any order, judgment or decree, not subsequently
reversed, suspended or vacated, of any competent jurisdiction or of any Federal or state governmental or quasi-governmental agency, authority or commission enjoining him or her or otherwise limiting him or her from engaging in any type of business
practice or in any activity in connection with the purchase or sale of any security or commodity, (vi) the consent of the recommended person to serve as a director of the Company in the event that he or she is elected, (vii) the
relationship between the proposed nominee and the recommending stockholder, and (viii) a statement setting forth the qualifications of the nominee.

Prior to the formation of the Nominating and Governance Committee, the Board of Directors considered recommendations of potential candidates from current directors, management and stockholders, and also
utilized the services of an executive search firm. In August 2009, the Board of Directors established a search committee comprised of our former Chairman of the Board, James Beery, Mr. Bologna and Ms. Williams to coordinate a search for
director candidates who could assist us in advancing our objectives and are otherwise appropriately qualified to serve on the Board of Directors. As a result of this search, Dr. Hart was elected to the Board of Directors
effective January 1, 2010 and Mr. Dalziel was elected to the Board of Directors effective April 1, 2010.



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On April 1, 2010, we received a notice from Accipiter Life Sciences Fund, LP and
certain of its affiliates for the nomination of three individuals, Eugene I. Davis, Gabe Hoffman and Stefan Loren, for election to our Board of Directors at the 2010 annual meeting of stockholders. On September 3, 2010, the Company executed an
agreement with Accipiter Capital Management, LLC and certain affiliates (Accipiter), pursuant to which the Company agreed (i) not to nominate for re-election the then current Class I directors of the Company at the 2010 annual
meeting of stockholders, (ii) two individuals proposed by Accipiter would be nominated for election at the 2010 annual meeting of stockholders, as members of the Companys slate of directors, to serve as Class I directors of the Company
for three-year terms ending in 2013, (iii) to invite certain major stockholders, other than Accipiter, to propose to the Board of Directors one individual for nomination for election to the Board of Directors at the 2010 annual meeting of
stockholders, (iv) to recommend, support and solicit proxies for the election of the Accipiter nominees in the same manner as it has in respect of the Companys nominees at previous annual meetings of stockholders, (v) to hold the
2010 annual meeting of stockholders in November 2010 and (vi) to hold the 2012 annual meeting of stockholders no earlier than June 2012.

Mr. Davis and Dr. Loren were proposed by Accipiter and subsequently nominated for election as directors of the Company pursuant to such agreement after the Nominating and Governance Committee
and the Board of Directors found such candidates to be suitable, and elected as members of the Board of Directors on November 9, 2010. In addition, the Company and Accipiter have agreed that if at any time prior to the date that is six months
after the one-year anniversary of the 2010 annual meeting of stockholders, if either of Mr. Davis and Dr. Loren resigns or is otherwise unable to serve as a director or is removed for cause as a director, Accipiter will have the right to
designate and substitute a person or persons for appointment to the Board of Directors as a replacement director, subject to evaluation and determination by the remaining members of the Nominating and Governance Committee and the Board of Directors.
If, at any time after the date that is six months after the one-year anniversary date of the 2010 annual meeting of stockholders, but prior to the Companys 2013 annual meeting of stockholders, if either of Mr. Davis or Dr. Loren
resigns or is otherwise unable to serve as a director or is removed for cause as a director, the Company shall notify Accipiter and give Accipiter five business days to recommend a person or persons for consideration by the Board of Directors and
the Nominating and Governance Committee as a replacement director for such vacancy. The Board of Directors and the Nominating and Governance Committee shall not appoint a replacement director for such vacancy until it has reviewed any such
recommendation of Accipiter.

The other major stockholders who were invited to propose an individual for nomination to the
Board of Directors declined such invitation.

For more information on the terms contained in the agreement with Accipiter, see
Item 11. Executive CompensationExecutive Officer and Director CompensationDirector Compensation Policy below.

Stockholder Communications with the Board of Directors

Generally, stockholders who have questions or concerns should contact our Investor Relations department at (609) 750-2324. However, any stockholders who wish to address questions regarding our
business directly with the Board of Directors, or any individual director, should direct his or her questions in writing to the Chairman of the Board of Directors or any member of the Board of Directors at 4390 US Route One, Princeton, NJ, 08540, or
via e-mail at ir@orchid.com.

The Board of Directors has instructed our Corporate Secretary to review all
communications so received (via regular mail or e-mail), and to exercise his discretion not to forward to the Board of Directors correspondence that is inappropriate such as business solicitations, frivolous communications and advertising, routine
business matters (i.e., business inquiries, complaints or suggestions) and personal grievances. However, any director may at any time request the Corporate Secretary to forward any and all communications received by the Corporate Secretary not
forwarded to the directors.

Section 16(a) Beneficial Ownership Reporting Compliance

Our executive officers, directors and 10% stockholders are required under Section 16(a) of the Securities Exchange Act of 1934, as
amended, to file reports of ownership and changes in ownership with the SEC. Copies of these reports must also be furnished to us.

Based solely on our review of copies of reports furnished to us, or written representations that no reports were required, we believe that during 2010 our executive officers, directors and 10%
stockholders complied with all filing requirements of Section 16(a) in a timely manner.



11



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##### Table of Contents

Code of Business Conduct and Ethics

Our Code of Business Conduct and Ethics, which is our code of ethics applicable to all directors, managers and employees worldwide,
embodies our global principles and practices relating to the ethical conduct of our business and our commitment to honesty, fair dealing and full compliance with all laws affecting our business. The text of the Code of Business Conduct and Ethics is
available on our website at www.orchidcellmark.com by first clicking on the section for Investor Relations and then Corporate Governance. The Code of Business Conduct and Ethics is also available without charge, to any
stockholder upon written request to the Corporate Secretary at Orchid Cellmark Inc., 4390 US Route One, Princeton, New Jersey 08540. Disclosure regarding any amendments to, or waivers from, provisions of the Code of Business Conduct and Ethics that
apply to our directors, principal executive and financial officers will be included in a Current Report on Form 8-K within four business days following the date of the amendment or waiver, unless website posting of such amendments or waivers is then
permitted by the rules of the Nasdaq Stock Market LLC.

Our Board of Directors has established a means for employees,
customers, suppliers, stockholders and other interested parties to submit confidential and anonymous reports of suspected or actual violations of our Code of Business Conduct and Ethics, such as:



| |  |  | accounting practices, internal accounting controls, or auditing matters and procedures;
| | - |  | ---------------------------------------------------------------------------------------



| |  |  | theft or fraud of any amount;
| | - |  | -----------------------------



| |  |  | insider trading;
| | - |  | ----------------



| |  |  | performance and execution of contracts;
| | - |  | ---------------------------------------



| |  |  | conflicts of interest;
| | - |  | ----------------------



| |  |  | violations of securities and antitrust laws; and
| | - |  | ------------------------------------------------



| |  |  | violations of the Foreign Corrupt Practices Act.
| | - |  | ------------------------------------------------

Any employee, stockholder or other interested party can call the following toll free number to submit a report. This number is operational 24 hours a day, seven days a week: 1-800-551-8902. Additionally,
an email address has been designated to receive reports: sox-compliance@USA.NET.



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##### Table of Contents

|Item 11. | EXECUTIVE COMPENSATION
|-------- | ----------------------

Executive
Officer and Director Compensation

Summary Compensation Table

The following table shows the compensation for the fiscal years ended December 31, 2010 and 2009 earned by (1) our President and
Chief Executive Officer, (2) our Vice President and Chief Financial Officer, and (3) our Vice President and General Counsel.



|                                                          |  |      |          |  |           |  |                |          |  |  |                    |     |  |                          |                |          |           |  |               |          |  |  |                  | 
|--------------------------------------------------------- |  | ---- | -------- |  | --------- |  | -------------- | -------- |  |  | ------------------ | --- |  | ------------------------ | -------------- | -------- | --------- |  | ------------- | -------- |  |  | ---------------- | 
|Name and Principal Position                               |  | Year |          |  | Salary($) |  |                | Bonus($) |  |  | OptionAwards($)(1) |     |  | All
OtherCompensation($) |                |          | Total ($) | 
|Thomas A. Bologna
President and Chief Executive Officer   |  |      | 20102009 |  |           |  | 581,950565,000 |          |  |  | 293,800           | (2) |  |                          | 184,926180,880 | (3)(5)   |           |  | 131,16889,232 | (4)(6)   |  |  | 1,191,844835,112 | 
|                                                          |  |      |          |  |           | 
|James F. Smith
Vice President and Chief Financial Officer |  |      | 20102009 |  |           |  | 251,000247,100 |          |  |  | 62,000            | (2) |  |                          | 48,95147,880   | (7)(9)   |           |  | 10,0485,866   | (8)(10)  |  |  | 371,999300,846   | 
|                                                          |  |      |          |  |           | 
|William J. Thomas
Vice President and General Counsel      |  |      | 20102009 |  |           |  | 249,812246,100 |          |  |  | 60,000            | (2) |  |                          | 48,95147,880   | (11)(13) |           |  | 5,4694,641    | (12)(14) |  |  | 364,232298,621   | 



|(1) | The amounts reported in the Option Awards column represent the aggregate grant date fair value of the stock options computed in accordance with ASC Topic 718 granted to
our named executive officers during 2010 and 2009. The grant date fair value of performance awards is determined based on the probable outcome of such performance conditions as of the grant date. Pursuant to SEC rules, the amounts reported exclude
the impact of estimated forfeitures related to service-based vesting conditions. The assumptions made in calculating the aggregate grant date fair value amounts for the options granted in 2010 and 2009 are described in Note 2 to our Consolidated
Financial Statements included in our Annual Report on Form 10-K for our fiscal year ended December 31, 2010, filed with the SEC on March 15, 2011.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | Represents a cash bonus for performance during 2010, which was paid in 2011.
|--- | ----------------------------------------------------------------------------

|(3) | Represents the aggregate grant date fair value of options computed in accordance with ASC Topic 718 granted to Mr. Bologna to purchase 170,000 shares of Common
Stock on May 26, 2010.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(4) | Consists of $4,900 of matching contributions under our 401(k) plan, $29,097 of contributions by us into our Executive Deferred Compensation Plan for the benefit of
Mr. Bologna, $5,148 in life insurance premiums paid by us for a life insurance policy to benefit Mr. Bologna, $52,851 in relocation and related expenses and $39,172 in tax gross-ups.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(5) | Represents the aggregate grant date fair value of options computed in accordance with ASC Topic 718 granted to Mr. Bologna to purchase 170,000 shares of Common
Stock on June 25, 2009.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(6) | Consists of $4,900 of matching contributions under our 401(k) plan, $28,250 of contributions by us into our Executive Deferred Compensation Plan for the benefit of
Mr. Bologna, $4,496 in life insurance premiums paid by us for a life insurance policy to benefit Mr. Bologna, $25,000 in relocation and related expenses and $26,586 in tax gross-ups.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(7) | Represents the aggregate grant date fair value of options computed in accordance with ASC Topic 718 granted to Mr. Smith to purchase 45,000 shares of Common Stock
on May 26, 2010.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(8) | Consists of $4,900 of matching contributions under our 401(k) plan and $5,148 in life insurance premiums paid by us for a life insurance policy for the benefit of
Mr. Smith.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(9) | Represents the aggregate grant date fair value of options computed in accordance with ASC Topic 718 granted to Mr. Smith to purchase 45,000 shares of Common Stock
on June 25, 2009.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(10) | Consists of $4,900 of matching contributions under our 401(k) plan and $966 in life insurance premiums paid by us for a life insurance policy for the benefit of
Mr. Smith.
|---- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(11) | Represents the aggregate grant date fair value of options computed in accordance with ASC Topic 718 granted to Mr. Thomas to purchase 45,000 shares of Common Stock
on May 26, 2010.
|---- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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|(12) | Consists of $3,675 of matching contributions under our 401(k) plan and $1,794 in life insurance premiums paid by us for a life insurance policy for the benefit of
Mr. Thomas.
|---- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(13) | Represents the aggregate grant date fair value of options computed in accordance with ASC Topic 718 granted to Mr. Thomas to purchase 45,000 shares of Common Stock
on June 25, 2009.
|---- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(14) | Consists of $3,675 of matching contributions under our 401(k) plan and $966 in life insurance premiums paid by us for a life insurance policy for the benefit of
Mr. Thomas.
|---- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Discussion of Summary Compensation Table

The terms of Mr. Bolognas compensation are derived from our employment agreement with him (further described below) and the
annual performance review by our Compensation Committee. The terms of Mr. Bolognas employment agreement with us were the result of extensive negotiations between us and Mr. Bologna and were approved by our Board of Directors. Annual
salary increases, annual equity awards and cash bonuses, if any, for Mr. Bologna are determined by the Board of Directors, after the recommendation from the Compensation Committee. The terms of our other named executive officers
compensation are derived from our employment agreement with each executive (further described below), which terms were the result of negotiations with each executive. Annual salary increases, annual equity awards and cash bonuses, if any, for these
executives are determined by the Compensation Committee based upon the recommendation of Mr. Bologna.

Base Salary

Effective April 1, 2010, the annual base salaries of Mr. Bologna, Mr. Smith, and Mr. Thomas were $587,600 (increased
from $565,000), $252,300 (increased from $247,000), and $251,050 (increased from $246,000), respectively.

Bonuses

In February 2010, the Compensation Committee definitively established 2010 goals and objectives for our executive officers. Bonus awards
for 2010 performance, which were paid in 2011 and are reflected in the Summary Compensation Table, were based on a subjective review of each executive officers performance and achievement of the following corporate objectives:



| |  |  | comparing actual 2010 financial performance to the Companys business plan, including revenue, gross margin and cash position;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------



| |  |  | reducing certain outside legal expenses;
| | - |  | ----------------------------------------



| |  |  | reducing certain intellectual property expenses;
| | - |  | ------------------------------------------------



| |  |  | realizing a specific level of revenue per reporting officer in the United Kingdom;
| | - |  | ----------------------------------------------------------------------------------



| |  |  | realizing a specific level of revenue from U.S. forensic casework;
| | - |  | ------------------------------------------------------------------



| |  |  | realizing a specific level of revenue from the National Procurement Plan in the United Kingdom or secure non-procurement business to make up for the
shortfall;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | pursuing acquisition candidates; and
| | - |  | ------------------------------------



| |  |  | completing the consolidation of the operations of our Nashville, Tennessee forensic DNA testing facility into our Dallas, Texas facility and the
consolidation of our East Lansing, Michigan paternity testing operations into our Dayton, Ohio facility by the projected dates in 2010 and within the restructuring cost projections.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

The Compensation Committee determined to award Mr. Bologna 100% of his target bonus (50% of his 2010 base salary), Mr. Smith
approximately 98% of his target bonus (25% of his 2010 base salary), and Mr. Thomas approximately 96% of his target bonus (25% of his 2010 base salary).

Option Awards

All of the stock option awards granted in 2010 to our named
executive officers were granted on May 26, 2010 under our Amended and Restated 2005 Stock Plan and in accordance with our practice of making annual stock option awards as part of our overall annual review process. All option awards were granted
with an exercise price per share equal to the



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closing price of our Common Stock on the Nasdaq Global Market on May 25, 2010 (the day prior to the grant date). Subject to the terms and conditions of the Amended and Restated 2005 Stock
Plan and the option agreements issued in connection with these grants, these options vest in equal monthly installments over four years following the date of grant.

Employment Agreements with Named Executive Officers

Employment Agreement with Thomas A.
Bologna

On March 8, 2006, we entered into an employment agreement with Thomas A. Bologna to serve as our
President and Chief Executive Officer effective April 25, 2006. The employment agreement is for a four-year term and automatically renews for additional four-year terms unless either party gives notice of non-renewal to the other party at least
18 months prior to the expiration of the then current term. Mr. Bolognas annual base salary was $587,600 in 2010, and he has a bonus target each year of 50% of his base salary, based primarily on performance measures. We also contribute
an additional 5% of Mr. Bolognas annual base salary to the Executive Deferred Compensation Plan for his benefit. Pursuant to the employment agreement, Mr. Bologna (i) received a signing bonus of $100,000, which was subject to
pro rata repayment if Mr. Bolognas employment was terminated for certain reasons within the first year of joining the Company, (ii) was granted an option to purchase 600,000 shares of our Common Stock at an exercise price equal to
$4.53 per share, and (iii) was granted 100,000 shares of our Common Stock at no cost to Mr. Bologna based upon Mr. Bolognas performance. In addition, we agreed to purchase life insurance on Mr. Bologna in the face amount of
not less than $2,000,000 for a beneficiary designated by him.

In connection with his employment, Mr. Bologna relocated
to the Princeton, New Jersey area in 2007. We reimbursed Mr. Bologna $52,851 in 2010 for certain relocation expenses, which are subject to pro rata repayment in certain circumstances. We also made an additional gross-up payment to
Mr. Bologna of $39,172 in 2010 in order to pay income tax imposed on him because certain payments made to Mr. Bologna under the employment agreement are deemed compensation to Mr. Bologna.

Waiver and Release with Mr. Bologna

In connection with the Merger Agreement, we and Mr. Bologna executed a waiver and release, dated April 5, 2011, relating to certain potential claims related to stock options (the Waiver
and Release). Under the Waiver and Release, provided that (i) the Acceptance Time (as defined in the Merger Agreement) occurs within 120 days (or 210 days, if the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of
1976, as amended, is applicable to the tender offer) of execution of the Waiver and Release and (ii) Mr. Bologna receives all consideration to which he is otherwise entitled under his employment agreement and stock option agreements and in
connection with the tender offer, then, with regard only to Mr. Bolognas stock options granted under his employment agreement and stock option agreements with exercise prices that are higher than the $2.80 per share tender offer price
(the Subject Option Awards), Mr. Bologna waives and releases us from all claims for compensation with respect to such Subject Option Awards or to exercise such Subject Option Awards after the consummation of the transactions
contemplated by the Merger Agreement.

Employment Agreement with James F. Smith

On October 5, 2007, we entered into an employment agreement with James F. Smith to serve as our Vice President and Chief Financial
Officer effective October 5, 2007. The employment agreement is for a three-year term and automatically renews for additional one-year terms unless either party gives notice of non-renewal to the other party at least three months prior to the
expiration of the then current term. Mr. Smiths annual base salary was $252,300 in 2010, and he has a bonus target each year of 25% of his base salary, based primarily on performance measures. Pursuant to the employment agreement,
Mr. Smith (i) was granted an option to purchase 75,000 shares of our Common Stock at an exercise price equal to $5.54 per share and (ii) was required to purchase $10,000 of our Common Stock in the open-market within six months after
his commencement of employment, subject to compliance with our insider trading policy and applicable securities laws.

Employment Agreement
with William J. Thomas

On November 19, 2007, we entered into an employment agreement with William J. Thomas to serve
as our Vice President and General Counsel effective November 19, 2007. The employment agreement is for a three-year term and automatically renews for additional one-year terms unless either party gives notice of non-renewal to the other party
at least three months prior to the expiration of the then current term. Mr. Thomas annual base salary was $251,050 in 2010, and he has a bonus target each year of 25% of his base salary, based primarily on performance measures. Pursuant
to the employment agreement, Mr. Thomas (i) was granted an option to purchase 75,000 shares of our Common Stock at an exercise price equal to $4.59 per share and (ii) received a signing bonus of $10,000, which was subject to full
repayment if



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Mr. Thomas employment was terminated for certain reasons within the first six months of joining the Company and was subject to 50% repayment if Mr. Thomas employment was
terminated for certain reasons within the first year of employment.

Potential Payments upon Termination or Change of Control

Generally, regardless of the manner in which a named executive officers employment terminates, he is entitled to
receive amounts earned during his term of employment. Such amounts include:



| |  |  | the portion of the executives base salary that has accrued prior to any termination and not yet been paid;
| | - |  | -----------------------------------------------------------------------------------------------------------



| |  |  | unused vacation pay pro-rated for the executive officers last year of employment;
| | - |  | ----------------------------------------------------------------------------------



| |  |  | distribution under the executives 401(k) plan (assuming the executive participated in the plan); and
| | - |  | -----------------------------------------------------------------------------------------------------



| |  |  | amounts contributed by the executive and us under our Executive Deferred Compensation Plan (assuming the executive participated in the plan).
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------

In addition, we have entered into certain agreements and maintain certain plans that may require us to make
additional payments and/or provide additional benefits to the individuals named in the Summary Compensation Table in the event of a termination of employment or a change of control of the Company.

Amended and Restated 2005 Stock Plan

Under our Amended and Restated 2005 Stock Plan, if we are to be consolidated with or acquired by another entity in a merger, sale of all or substantially all of our assets or otherwise, the administrator
of our Amended and Restated 2005 Stock Plan or the board of directors of any entity assuming our obligations under the Amended and Restated 2005 Stock Plan shall, as to outstanding options, either (i) make appropriate provision for the
continuation of such options by substituting on an equitable basis for the shares then subject to such options either the consideration payable with respect to the outstanding shares of our Common Stock in connection with the transaction or
securities of any successor or acquiring entity, (ii) upon written notice to the participants, provide that all options must be exercised (either (a) to the extent then exercisable or (b) at the discretion of the administrator of the
Amended and Restated 2005 Stock Plan, all options being made fully exercisable) within a specified number of days of the date of such notice, at the end of which period the options shall terminate or (iii) terminate all options in exchange for
a cash payment equal to the excess of the fair market value of the shares subject to such options as determined in accordance with the Amended and Restated 2005 Stock Plan (either (a) to the extent then exercisable or (b) at the discretion
of the administrator of the Amended and Restated 2005 Stock Plan, all options being made fully exercisable) over the exercise price thereof.

With respect to outstanding stock grants, the administrator of the Amended and Restated 2005 Stock Plan or the successor board, shall either (i) make appropriate provisions for the continuation of
such stock grants by substituting on an equitable basis for the shares then subject to such stock grants either the consideration payable with respect to the outstanding shares of our Common Stock in connection with the transaction or securities of
any successor or acquiring entity, (ii) upon written notice to the participants, provide that all stock grants must be accepted (to the extent then subject to acceptance) within a specified number of days of the date of such notice, at the end
of which period the offer of the stock grants shall terminate or (iii) terminate all stock grants in exchange for a cash payment equal to the excess of the fair market value of the shares subject to such stock grants over the purchase price
thereof, if any. In addition, in the event of such a transaction, the administrator of the Amended and Restated 2005 Stock Plan may waive any or all of our repurchase rights with respect to outstanding stock grants.

Executive Deferred Compensation Plan

Benefits under our Executive Deferred Compensation Plan are typically paid six months after termination in order to comply with Section 409A of the Internal Revenue Code. Benefits can be received
either as a lump sum payment or in annual installments as designated by the executive at or prior to the time of deferral.

Termination and
Change of Control Arrangements with Thomas A. Bologna, President and Chief Executive Officer

Pursuant to our employment
agreement with Mr. Bologna, in the event of a change of control, all stock options held by Mr. Bologna which have not previously vested shall immediately and fully vest and shall remain exercisable for their full term. If
Mr. Bolognas employment is terminated by us without cause or by Mr. Bologna for good reason, then immediately



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##### Table of Contents

upon the date of Mr. Bolognas termination, to the extent that any of Mr. Bolognas stock options have not vested in full, an additional number of Mr. Bolognas
stock options will vest such that Mr. Bologna will be vested in such number of stock options calculated as if Mr. Bologna remained employed with us for an additional 24 months following the date of termination, and the vested options shall
remain exercisable for their full term. If Mr. Bolognas employment is terminated as a result of his death or disability, then immediately upon the date of Mr. Bolognas termination, all stock options held by Mr. Bologna
shall immediately and fully vest and shall remain exercisable for their full term.

If Mr. Bolognas employment
under his employment agreement is terminated by us for cause or by Mr. Bologna in the absence of a good reason, or the term of the employment agreement expires, we will pay to Mr. Bologna his accrued but unpaid salary, his accrued unused
vacation and his unreimbursed expenses. If Mr. Bolognas employment under the employment agreement is terminated either by us without cause or by Mr. Bologna for good reason, or because of Mr. Bolognas death or disability,
then (i) we will pay to Mr. Bologna his accrued but unpaid salary, his accrued unused vacation and his unreimbursed expenses, (ii) we will pay Mr. Bologna a lump sum payment equal to (A) an amount equal to two times his most
recent base salary plus (B) an amount equal to two times the average of the last four annual bonuses paid to him, or two times the amount of the largest bonus paid to him within the last three years, whichever is greater, (iii) we will pay
Mr. Bologna an amount equal to his annual bonus target prorated by the number of days worked by him in the last calendar year of his employment and (iv) in certain circumstances we will continue to provide medical and dental insurance
coverage for him and his family until the later of (A) 36 months following the effective date of his termination or (B) the date which would have been the end of the current term of the employment agreement but for the earlier termination
thereof.

Under the employment agreement, cause means that Mr. Bologna has (i) intentionally committed
an act or omission that materially harms us, (ii) been grossly negligent in performance of his duties to us, (iii) committed an act of moral turpitude, (iv) committed an act of fraud or material dishonesty in discharging his duties to
us, (v) breached any material provision of the employment agreement or any nondisclosure or non-competition agreement between us and Mr. Bologna that results in material harm to us, or (vi) breached any material provision of any code
of conduct or ethics policy in effect at the Company that results in material harm to us; provided, that in the case of subparagraph (ii) where such gross negligence and the effects of such gross negligence are capable of remedy by
Mr. Bologna, there shall be no cause unless we provide Mr. Bologna with written notice reasonably detailing the purported basis for the cause and Mr. Bologna fails to remedy within 30 days after his receipt of such notice.

Under the employment agreement, good reason means the occurrence of one or more of the following without
Mr. Bolognas express written consent: (i) a substantial diminution in his title, duties, responsibilities or authority with us, (ii) a reduction in his salary or bonus target, (iii) our failure to timely pay or provide him
with any salary, bonuses, benefits or other compensation due to him under the employment agreement, (iv) our dissolution or liquidation or our filing of a bankruptcy petition, (v) relocation of our headquarters to a location outside of the
Princeton, New Jersey area, (vi) Mr. Bologna not being elected as a member of our Board of Directors or (vii) a change of control as used in the employment agreement; provided, that in the case of subparagraphs (i), (ii) or
(iii) there shall be no good reason unless Mr. Bologna provides our Board of Directors with written notice reasonably detailing the purported basis for the good reason and we fail to remedy within 30 days after its receipt of such
notice.

Under the employment agreement, a change of control shall occur on the date that either of the following
occurs: (i) any Person (as such term is used in Sections 13(d) and 14(d) of the Securities Exchange Act of 1934, as amended) becomes the Beneficial Owner (as defined in Rule 13d-3 under said Act), directly or indirectly,
of our securities representing more than 50% of the total voting power represented by our then outstanding voting securities (excluding for this purpose our company or its affiliated entities or any of our executive benefit plans) or (ii) a
merger or consolidation of the Company whether or not approved by our Board of Directors, other than a merger or consolidation which would result in our voting securities outstanding immediately prior thereto continuing to represent (either by
remaining outstanding or by being converted into voting securities of the surviving entity or the parent of such corporation) at least 50% of the total voting power represented by our voting securities or the voting securities of such surviving
entity or parent of such corporation outstanding immediately after such merger or consolidation, or the consummation of an agreement for the sale or disposition of all or substantially all of our assets.

Termination and Change of Control Arrangements with James F. Smith, Vice President and Chief Financial Officer

Pursuant to our employment agreement with Mr. Smith, in the event of a change of control, all stock options held by Mr. Smith
which have not previously vested shall immediately vest and become fully exercisable.

If Mr. Smiths employment
under his employment agreement is terminated by us for cause, or death or disability, or the term of the employment agreement expires, we will pay to Mr. Smith his accrued but unpaid salary, his accrued unused



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vacation and his unreimbursed expenses. If Mr. Smiths employment under the employment agreement is terminated by us without cause, but not as a result of a change of control, then
(i) we will pay to Mr. Smith his accrued but unpaid salary, his accrued unused vacation and his unreimbursed expenses, and (ii) we will pay Mr. Smith severance consisting of a payment either, in accordance with our usual payroll
practices, in a lump sum or in up to four payments within six months after his termination in an amount equal to six months base salary. If Mr. Smiths employment under his employment agreement is terminated by us within nine months
following a change of control, and provided Mr. Smith is not offered employment with any successor or surviving entity at substantially equal or better terms and conditions, then we will pay Mr. Smith severance equal to 18 months base
salary, in accordance with our usual payroll practices, in a lump sum or in up to four payments within 18 months.

Under the
employment agreement, cause means that Mr. Smith has (i) intentionally committed an act or omission that materially harms us, (ii) been grossly negligent in performance of his duties to us, (iii) committed an act of
moral turpitude, (iv) committed an act of fraud or material dishonesty in discharging his duties to us, (v) breached any material provision of the employment agreement or any nondisclosure or non-competition agreement between us and
Mr. Smith that results in material harm to us, or (vi) breached any provision of any code of conduct or ethics policy in effect at the Company; provided, that in the case of subparagraph (ii) where such gross negligence and the
effects of such gross negligence are capable of remedy by Mr. Smith, there shall be no cause unless we provide Mr. Smith with written notice reasonably detailing the purported basis for the cause and Mr. Smith fails to remedy within
30 days after his receipt of such notice.

Under the employment agreement, a change of control shall occur on
the date that either of the following occurs: (i) any Person (as such term is used in Sections 13(d) and 14(d) of the Securities Exchange Act of 1934, as amended) becomes the Beneficial Owner (as defined in Rule 13d-3
under said Act), directly or indirectly, of our securities representing more than 50% of the total voting power represented by our then outstanding voting securities (excluding for this purpose our company or its affiliated entities or any of
our employee benefit plans) or (ii) a merger or consolidation of the Company whether or not approved by our Board of Directors, other than a merger or consolidation which would result in our voting securities outstanding immediately prior
thereto continuing to represent (either by remaining outstanding or by being converted into voting securities of the surviving entity or the parent of such corporation) at least 50% of the total voting power represented by our voting securities
or the voting securities of such surviving entity or parent of such corporation outstanding immediately after such merger or consolidation, or the consummation of an agreement for the sale or disposition of all or substantially all of our assets.

Termination and Change of Control Arrangements with William J. Thomas, Vice President and General Counsel

Pursuant to our employment agreement with Mr. Thomas, in the event of a change of control, all stock options held by Mr. Thomas
which have not previously vested shall immediately vest and become fully exercisable.

If Mr. Thomas employment
under his employment agreement is terminated by us for cause, or death or disability, or the term of the employment agreement expires, we will pay to Mr. Thomas his accrued but unpaid salary, his accrued unused vacation and his unreimbursed
expenses. If Mr. Thomas employment under the employment agreement is terminated by us without cause, then (i) we will pay to Mr. Thomas his accrued but unpaid salary, his accrued unused vacation and his unreimbursed expenses,
and (ii) we will pay Mr. Thomas severance consisting of a payment either, in accordance with our usual payroll practices, in a lump sum or in up to four payments within six months after his termination in an amount equal to six months base
salary.

Under the employment agreement, cause means that Mr. Thomas has (i) intentionally committed an
act or omission that materially harms us, (ii) been grossly negligent in performance of his duties to us, (iii) committed an act of moral turpitude, (iv) committed an act of fraud or material dishonesty in discharging his duties to
us, (v) breached any material provision of the employment agreement or any other agreement with the Company that results in material harm to us, or (vi) breached any provision of any code of conduct or ethics policy in effect at the
Company; provided, that in the case of subparagraph (ii) where such gross negligence and the effects of such gross negligence are capable of remedy by Mr. Thomas, there shall be no cause unless we provide Mr. Thomas with written
notice reasonably detailing the purported basis for the cause and Mr. Thomas fails to remedy within 30 days after his receipt of such notice.

Under the employment agreement, a change of control shall occur on the date that either of the following occurs: (i) any Person (as such term is used in Sections 13(d) and
14(d) of the Securities Exchange Act of 1934, as amended) becomes the Beneficial Owner (as defined in Rule 13d-3 under said Act), directly or indirectly, of our securities representing more than 50% of the total voting power represented
by our then outstanding voting securities (excluding for this purpose our company or its affiliated entities or any of our employee benefit plans) or (ii) a merger or consolidation of



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the Company whether or not approved by our Board of Directors, other than a merger or consolidation which would result in our voting securities outstanding immediately prior thereto continuing to
represent (either by remaining outstanding or by being converted into voting securities of the surviving entity or the parent of such corporation) at least 50% of the total voting power represented by our voting securities or the voting
securities of such surviving entity or parent of such corporation outstanding immediately after such merger or consolidation, or the consummation of an agreement for the sale or disposition of all or substantially all of our assets.



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Outstanding Equity Awards at Fiscal Year-End

The following table shows grants of stock options outstanding on December 31, 2010, the last day of our most recently completed
fiscal year, to each of the individuals named in the Summary Compensation Table.



|                  |  |                                                                |         |  |                                                                   |  |         |                          |  |  |                       |  |  |  |          | 
|----------------- |  | -------------------------------------------------------------- | ------- |  | ----------------------------------------------------------------- |  | ------- | ------------------------ |  |  | --------------------- |  |  |  | -------- | 
|                  |  | Option Awards                                                  |        
|Name              |  | Number ofSecuritiesUnderlyingUnexercisedOptions (#)Exercisable |         |  | Number ofSecuritiesUnderlyingUnexercisedOptions 
(#)Unexercisable |  |         | Option ExercisePrice ($) |  |  | OptionExpiration Date | 
|Thomas A. Bologna |  |                                                                | 600,000 |  |                                                                   |  |        |                          |  |  | 4.53                  |  |  |  | 4/25/16  | 
|                  |  |                                                                | 90,625  |  |                                                                   |  | 54,375  | (1)                      |  |  | 3.03                  |  |  |  | 6/05/18  | 
|                  |  |                                                                | 170,000 |  |                                                                   |  |        |                          |  |  | 1.54                  |  |  |  | 6/25/19  | 
|                  |  |                                                                | 24,792  |  |                                                                   |  | 145,208 | (2)                      |  |  | 1.64                  |  |  |  | 5/26/20  | 
|                  |  |                                                                |         | 
|James F. Smith    |  |                                                                | 59,375  |  |                                                                   |  | 15,625  | (3)                      |  |  | 5.54                  |  |  |  | 10/31/17 | 
|                  |  |                                                                | 15,734  |  |                                                                   |  | 9,441   | (4)                      |  |  | 3.03                  |  |  |  | 6/05/18  | 
|                  |  |                                                                | 45,000  |  |                                                                   |  |        |                          |  |  | 1.54                  |  |  |  | 6/25/19  | 
|                  |  |                                                                | 6,563   |  |                                                                   |  | 38,437  | (5)                      |  |  | 1.64                  |  |  |  | 5/26/20  | 
|                  |  |                                                                |         | 
|William J. Thomas |  |                                                                | 57,813  |  |                                                                   |  | 17,187  | (3)                      |  |  | 4.59                  |  |  |  | 11/19/17 | 
|                  |  |                                                                | 12,778  |  |                                                                   |  | 7,667   | (6)                      |  |  | 3.03                  |  |  |  | 6/05/18  | 
|                  |  |                                                                | 45,000  |  |                                                                   |  |        |                          |  |  | 1.54                  |  |  |  | 6/25/19  | 
|                  |  |                                                                | 6,563   |  |                                                                   |  | 38,437  | (5)                      |  |  | 1.64                  |  |  |  | 5/26/20  | 



|(1) | This option vests as to 3,021 shares on a monthly basis.
|--- | --------------------------------------------------------

|(2) | This option vests as to 3,542 shares on a monthly basis
|--- | -------------------------------------------------------

|(3) | This option vests as to 1,562 shares on a monthly basis.
|--- | --------------------------------------------------------

|(4) | This option vests as to 524 shares on a monthly basis.
|--- | ------------------------------------------------------

|(5) | This option vests as to 938 shares on a monthly basis.
|--- | ------------------------------------------------------

|(6) | This option vests as to 426 shares on a monthly basis.
|--- | ------------------------------------------------------

Director Compensation Table

The following table sets forth a summary of
the compensation earned by our directors for the fiscal year ended December 31, 2010, other than Thomas A. Bologna, our President and Chief Executive Officer.



|                             |  |                               |        |  |                    |  |         |          |  |  |         | 
|---------------------------- |  | ----------------------------- | ------ |  | ------------------ |  | ------- | -------- |  |  | ------- | 
|Name                         |  | Fees Earned orPaid in Cash($) |        |  | OptionAwards($)(1) |  |         | Total($) | 
|James Beery(2)               |  |                               | 44,500 |  |                    |  |        |          |  |  | 44,500  | 
|Eugene I. Davis(3)           |  |                               |       |  |                    |  |        |          |  |  |        | 
|Bruce D. Dalziel(4)          |  |                               | 22,426 |  |                    |  | 102,498 | (5)      |  |  | 124,924 | 
|James M. Hart, Ph.D.(6)      |  |                               | 23,470 |  |                    |  | 74,242  | (7)      |  |  | 97,712  | 
|Sidney M. Hecht, Ph.D.(8)    |  |                               | 33,500 |  |                    |  |        |          |  |  | 33,500  | 
|Stefan Loren, Ph.D.(9)       |  |                               |       |  |                    |  |        |          |  |  |        | 
|Kenneth D. Noonan, Ph.D.(10) |  |                               | 23,500 |  |                    |  |        |          |  |  | 23,500  | 
|Nicole S. Williams(11)       |  |                               | 38,000 |  |                    |  |        |          |  |  | 38,000  | 



|(1) | The amounts reported in the Option Awards column represent the aggregate grant date fair value of the stock options computed in accordance with ASC Topic 718 granted to
our directors during 2010. Pursuant to SEC rules, the amounts reported exclude the impact of estimated forfeitures related to service-based vesting conditions. The assumptions made in calculating the aggregate grant date fair value amounts for the
options granted in 2010 are described in Note 2 to our Consolidated Financial Statements included in our Annual Report on Form 10-K for our fiscal year ended December 31, 2010, filed with the SEC on March 15, 2011.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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|(2) | Mr. Beery served as a member of our Board of Directors and as Chairman during 2010 and did not stand for re-election at the 2010 annual stockholders meeting.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------

|(3) | Mr. Davis was elected to the Board of Directors effective November 9, 2010. As of December 31, 2010, Mr. Davis held no options to purchase shares of
Common Stock.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(4) | Mr. Dalziel was elected to the Board of Directors effective April 1, 2010.
|--- | --------------------------------------------------------------------------

|(5) | Represents the aggregate grant date fair value of options computed in accordance with ASC Topic 718 granted to Mr. Dalziel to purchase 61,882 shares of Common
Stock on April 1, 2010 ($77,167 grant date fair value) and 18,439 shares of Common Stock on May 5, 2010 ($25,331 grant date fair value). As of December 31, 2010, Mr. Dalziel held options to purchase 80,321 shares of Common Stock,
of which 13,003 were vested.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(6) | Dr. Hart was elected to the Board of Directors effective January 1, 2010.
|--- | -------------------------------------------------------------------------

|(7) | Represents the aggregate grant date fair value of options computed in accordance with ASC Topic 718 granted to Dr. Hart to purchase 64,157 shares of Common Stock
on January 1, 2010. As of December 31, 2010, Dr. Hart held options to purchase 64,157 shares of Common Stock, of which 19,604 were vested.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(8) | Dr. Hecht served as a member of our Board of Directors during 2010 and did not stand for re-election at the 2010 annual stockholders meeting.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------

|(9) | Dr. Loren was elected to the Board of Directors effective November 9, 2010. As of December 31, 2010, Dr. Loren held no options to purchase shares of
Common Stock.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(10) | Dr. Noonan served as a member of our Board of Directors during 2010 and did not stand for re-election at the 2010 annual stockholders meeting.
|---- | ----------------------------------------------------------------------------------------------------------------------------------------------

|(11) | As of December 31, 2010, Ms. Williams held options to purchase 182,666 shares of Common Stock, of which 151,229 were vested.
|---- | ----------------------------------------------------------------------------------------------------------------------------

Director Compensation Policy

Mr. Bologna, our President and Chief Executive Officer, is not paid any fees or other compensation for services as a member of our Board of Directors or of any committee of our Board of Directors.

On September 3, 2010, Accipiter and the Company entered into an agreement, pursuant to which the Company agreed, as soon
as practicable following the 2010 annual meeting of stockholders, to engage a third party compensation consultant to conduct a director compensation study and to implement compensation and stock ownership guidelines based upon the recommendations of
such study, subject to the review and approval of the recommendations by the Board of Directors. Compensation guidelines shall evaluate the compensation of directors over an entire three-year term of service. Stock ownership guidelines shall take
into account the time of service of each member of the Board. Any failure of a member of the Board of Directors to comply with the new guidelines may not be remedied through the grant by the Company of additional shares of restricted stock or
options, nor through the payment by the Company for future or past services in lieu of cash. The guidelines will obligate all members of the Board to be in compliance with said guidelines within the earlier of nine months of the adoption by the
Board of the guidelines or the date of the 2011 annual meeting of stockholders of the Company. The Company also agreed that no additional equity compensation will be issued to non-executive directors of the Company until the compensation study is
completed.



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Cash Compensation

The non-employee members of our Board of Directors are entitled to receive cash compensation in accordance with the following schedule:



|                                                                                          |  |   |        | 
|----------------------------------------------------------------------------------------- |  | - | ------ | 
|Board of Directors:                                                                       |  |   |        | 
|Annual retainer-Chairperson                                                               |  | $ | 25,000 | 
|Annual retainer-Director                                                                  |  | $ | 12,500 | 
|In person meeting fee                                                                     |  | $ | 3,000  | 
|Telephonic meetings will be paid at the prorated level of $500 per hour.                  |  |   |        | 
|                                                                                          | 
|Audit Committee:                                                                          |  |   |        | 
|Annual retainer-Chairperson                                                               |  | $ | 5,000  | 
|Annual retainer-committee members                                                         |  | $ | 1,500  | 
|In person meeting fee                                                                     |  | $ | 1,000  | 
|In person meeting fee (meetings held on days separate from full Board meeting)            |  | $ | 3,000  | 
|Telephonic meetings will be paid at the prorated level of $500 per hour.                  |  |   |        | 
|                                                                                          | 
|Compensation Committee:                                                                   |  |   |        | 
|                                                                                          | 
|No annual retainer to be paid to Compensation Committee Chairperson or members.           |  |   |        | 
|In person meeting fee                                                                     |  | $ | 1,000  | 
|In person meeting fee (meetings held on days separate from full Board meeting)            |  | $ | 3,000  | 
|Telephonic meetings will be paid at the prorated level of $500 per hour.                  |  |   |        | 
|                                                                                          | 
|Nominating and Governance Committee:                                                      |  |   |        | 
|No annual retainer to be paid to Compensation Committee Chairperson or members.           |  |   |        | 
|In person meeting fee                                                                     |  | $ | 1,000  | 
|In person meeting fee (meetings held on days separate from full Board meeting)            |  | $ | 3,000  | 
|In person interview of Board candidate (where Committee member travels to meet candidate) |  | $ | 2,000  | 
|Telephonic meetings will be paid at the prorated level of $500 per hour.                  |  |   |        | 

Unless otherwise approved by the Board of Directors, any other committees of the Board of
Directors shall be treated at the same level of the Compensation Committee.

Equity Compensation

Pursuant to the agreement with Accipiter entered into on September 3, 2010, the Company agreed that no additional equity compensation
will be issued to non-executive directors of the Company until a compensation study is completed after the 2010 annual meeting of stockholders. Prior to the execution of the agreement, non-employee members of the Board of Directors and committee
members automatically received stock option grants both upon initially joining the Board of Directors or a committee thereof and on an annual basis in accordance with the following schedule, which grants were non-qualified stock options under our
Amended and Restated 2005 Stock Plan, which typically vested in monthly increments over three years:



|                    |  |   |         | 
|------------------- |  | - | ------- | 
|Board of Directors: |  |   |         | 
|Initial grant       |  | $ | 100,000 | 
|Annual grant        |  | $ | 75,000  | 



|(1) | The number of options is determined based on 30-day trailing average stock price (i.e., $100,000 divided by the 30-day trailing average stock price on date of grant).
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | Exercise price shall be equal to fair market value on date of grant as determined pursuant to the equity compensation plan under which the options are granted.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------

|(3) | After initial grant, director(s) must be in position for at least 3 months before qualifying for any annual grant.
|--- | ------------------------------------------------------------------------------------------------------------------



|                                       |  |   |        | 
|-------------------------------------- |  | - | ------ | 
|Audit Committee:                       |  |   |        | 
|Initial/annual grant-Chairperson       |  | $ | 35,000 | 
|Initial/annual grant-committee members |  | $ | 25,000 | 



|(1) | The number of options is determined based on 30-day trailing average stock price (i.e., $35,000 divided by the 30-day trailing average stock price on date of grant).
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | Exercise price shall be equal to fair market value on date of grant as determined pursuant to the equity compensation plan under which the options are granted.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------

|(3) | After initial grant, director(s) must be in position for at least 3 months before qualifying for any annual grant.
|--- | ------------------------------------------------------------------------------------------------------------------



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|                                       |  |   |        | 
|-------------------------------------- |  | - | ------ | 
|Compensation Committee:                |  |   |        | 
|Initial/annual grant-Chairperson       |  | $ | 15,000 | 
|Initial/annual grant-committee members |  | $ | 10,000 | 



|(1) | The number of options is determined based on 30-day trailing average stock price (i.e., $15,000 divided by the 30-day trailing average stock price on date of grant).
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | Exercise price shall be equal to fair market value on date of grant as determined pursuant to the equity compensation plan under which the options are granted.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------

|(3) | After initial grant, director(s) must be in position for at least 3 months before qualifying for any annual grant.
|--- | ------------------------------------------------------------------------------------------------------------------

Expense Reimbursement

We reimburse each member of our Board of Directors who is not an employee for reasonable travel and other expenses in connection with
attending meetings of the Board of Directors.



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|Item 12. | SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERS
|-------- | ----------------------------------------------------------------------------------------------

The following table sets forth the beneficial ownership of our Common Stock as of April 15, 2011, except as otherwise noted, for
(a) each stockholder known by the Company to own beneficially more than 5% of the Companys Common Stock; (b) each of our directors; (c) each executive officer named in the Summary Compensation Table above; and (d) all
current directors and executive officers of the Company as a group. Beneficial ownership is determined in accordance with the rules of the SEC and includes voting or investment power with respect to the securities. We deem shares of Common Stock
that may be acquired by an individual or group within the 60-day period following April 15, 2011 pursuant to the exercise of options, warrants, or rights to be outstanding for the purpose of computing the percentage ownership of such individual
or group, but such shares are not deemed to be outstanding for the purpose of computing the percentage ownership of any other person or group shown in the table. Percentage of ownership is based on 29,992,186 shares of Common Stock outstanding as of
April 15, 2011. The amounts set forth below give effect to the accelerated vesting of stock options that will result from the transactions contemplated by the Agreement and Plan of Merger, dated as of April 5, 2011, by and among Laboratory
Corporation of America Holdings, OCM Acquisition Corp. and the Company. Except as indicated in footnotes to this table, we believe that the stockholders named in this table have sole voting and investment power with respect to all shares of Common
Stock shown to be beneficially owned by them based on information provided to us by these stockholders. Unless otherwise indicated, the address for each director and executive officer is c/o Orchid Cellmark Inc., 4390 U.S. Route One, Princeton, New
Jersey 08540.



|                                                                                |  |                                          |           |     |         |  |      |  
|------------------------------------------------------------------------------- |  | ---------------------------------------- | --------- | --- | ------- |  | ---- | -
|                                                                                |  | Amount and Nature of BeneficialOwnership |          
|                                                                                |  | Common Stock                             |          
|5% Holders, Directors and Executive Officers                                    |  | Number (1)                               |           |     | Percent | 
|Bridger Management, LLC90 Park Avenue, 40thFloorNew York, NY 10016 (2)          |  |                                          | 3,962,179 | (3) |         |  | 13.2 | %
|                                                                                |  |                                         
|Accipiter Capital Management LLC666 5th Avenue, 35thFloorNew York, NY 10103 (4) |  |                                          | 3,923,498 | (3) |         |  | 13.1 | %
|                                                                                |  |                                         
|Royce & Associates, LLC745 Fifth AvenueNew York, NY 10151                       |  |                                          | 2,325,522 | (3) |         |  | 7.8  | %
|                                                                                |  |                                         
|Samana Capital L.P.283 Greenwich AvenueGreenwich, CT 06830 (5)                  |  |                                          | 2,145,798 | (3) |         |  | 7.2  | %
|Thomas A. Bologna (6)                                                           |  |                                          | 1,249,478 |     |         |  | 4.0  | %
|Bruce D. Dalziel (7)                                                            |  |                                          | 80,321    |     |         |  | *    |  
|Eugene I. Davis                                                                 |  |                                          |          |     |         |  | *    |  
|James M. Hart, Ph.D. (7)                                                        |  |                                          | 64,157    |     |         |  | *    |  
|Stefan Loren, Ph.D (8)                                                          |  |                                          | 2,000     |     |         |  | *    |  
|James F. Smith (9)                                                              |  |                                          | 193,275   |     |         |  | *    |  
|William J. Thomas (10)                                                          |  |                                          | 186,445   |     |         |  | *    |  
|Nicole S. Williams (7)                                                          |  |                                          | 182,666   |     |         |  | *    |  
|All current directors and executive officers as a group (nine persons) (11)     |  |                                          | 2,106,842 |     |         |  | 6.6  | %



|* | Represents beneficial ownership of less than 1% of the Common Stock outstanding.
|- | --------------------------------------------------------------------------------

|(1) | Attached to each share of Common Stock is a preferred share purchase right to acquire one one-hundredth of a share of our series A junior participating preferred stock,
par value $0.001 per share, which preferred share purchase rights are not presently exercisable.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | Represents shares of Common Stock held by accounts managed by Bridger Management, LLC. Robert C. Mignone is the managing member of each of Bridger Management, LLC. As a
result, Mr. Mignone and Bridger Management, LLC may be deemed to be the beneficial owners of all shares managed by Bridger Management, LLC. One of the accounts managed by Bridger Management, LLC, Swiftcurrent Offshore, Ltd., located at Cayman
Corporate Centre, 27 Hospital Road, P.O. Box 1748GT, George Town, Grand Cayman, Cayman Islands, beneficially owns 2,471,579 shares of such Common Stock, or 8.2% of the outstanding shares of Common Stock.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



24



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##### Table of Contents

|(3) | The number of shares is based on the most recent filing with the SEC by the stockholder.
|--- | ----------------------------------------------------------------------------------------

|(4) | Represents shares owned by Accipiter Life Sciences Fund, LP (ALSF) and Accipiter Life Sciences Fund (Offshore), Ltd. (Offshore). Accipiter
Capital Management, LLC (Management) is the investment manager of Offshore. Candens Capital, LLC (Candens) is the general partner of ALSF. Gabe Hoffman is the managing member of each of Management and Candens. As a result,
Gabe Hoffman, Management and Candens may be deemed to be the beneficial owners of all shares held by ALSF and Offshore. Each of ALSF, Offshore, Management, Candens and Mr. Hoffman disclaims beneficial ownership of the securities beneficially
owned by Accipiter and the other members of the group except to the extent of his or its pecuniary interest therein.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(5) | Morton Holdings, Inc. (MH) is the general partner of Samana Capital, L.P. Each of MH and Philip B. Korsant may be deemed to beneficially own the Common
Stock as a result of the direct or indirect power to vote or dispose of such stock.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(6) | Includes 5,626 shares of Common Stock held by the Thomas A. Bologna and Kathy M. Bologna Trust (the Bologna Trust) and 1,085,000 shares of Common Stock
subject to options. Mr. Bologna shares voting and investment power over the shares held by the Bologna Trust.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(7) | Represents shares of Common Stock subject to options.
|--- | -----------------------------------------------------

|(8) | Represents shares of outstanding Common Stock.
|--- | ----------------------------------------------

|(9) | Includes 190,175 shares of Common Stock subject to options.
|--- | -----------------------------------------------------------

|(10) | Consists of 1,000 shares of Common Stock held in Mr. Thomas IRA and 185,445 shares of Common Stock subject to options.
|---- | -----------------------------------------------------------------------------------------------------------------------

|(11) | Consists of the securities described in footnotes 6-10 and 8,500 shares of outstanding Common Stock and 140,000 shares of Common Stock subject to options held by one
executive officer not named in the table.
|---- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Equity Compensation Plan Information

The following table provides certain aggregate information with respect to all of our equity compensation plans in effect as of
December 31, 2010.



|                                                                                 |  |                                                                                              |           |  |                                                                               |  |      |                                                                                                                                        |  |  |         | 
|-------------------------------------------------------------------------------- |  | -------------------------------------------------------------------------------------------- | --------- |  | ----------------------------------------------------------------------------- |  | ---- | -------------------------------------------------------------------------------------------------------------------------------------- |  |  | ------- | 
|Plan category                                                                    |  | Number of securities to beissued upon exercise ofoutstanding
options,warrants and rights (1) |           |  | Weighted-average exerciseprice of outstanding options,warrants and rights
($) |  |      | Number of securitiesremaining
availablefor future issuanceunder equitycompensation plans(excluding securitiesreflected in firstcolumn) | 
|Equity compensation plans approved by security holders 1995 Stock Incentive Plan |  |                                                                                              | 100,163   |  |                                                                               |  | 9.48 |                                                                                                                                        |  |  |        | 
|Amended and Restated 2005 Stock Plan                                             |  |                                                                                              | 2,994,353 |  |                                                                               |  | 3.40 |                                                                                                                                        |  |  | 647,550 | 
|Equity compensation plans not approved by security holders                       |  |                                                                                              | N/A       |  |                                                                               |  | N/A  |                                                                                                                                        |  |  | N/A     | 
|Total                                                                            |  |                                                                                              | 3,094,512 |  |                                                                               |  | 3.60 |                                                                                                                                        |  |  | 647,550 | 



|(1) | Includes options to purchase 373,085 shares of our Common Stock issued under the plans that were cancelled between December 31, 2010 and March 31, 2011.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



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##### Table of Contents

|Item 13. | CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE
|-------- | -------------------------------------------------------------------------

Policy for Approval of Related Person Transactions

Pursuant to the written
charter of our Audit Committee, the Audit Committee is responsible for reviewing and approving, prior to our entry into any such transaction, all transactions in which we are a participant and in which any of the following persons has or will have a
direct or indirect material interest:



| |  |  | our executive officers;
| | - |  | -----------------------



| |  |  | our directors;
| | - |  | --------------



| |  |  | the beneficial owners of more than 5% of our securities;
| | - |  | --------------------------------------------------------



| |  |  | the immediate family members of any of the foregoing persons; and
| | - |  | -----------------------------------------------------------------



| |  |  | any other persons whom the Board determines may be considered related persons.
| | - |  | ------------------------------------------------------------------------------

For purposes of these procedures, immediate family members means any child, stepchild, parent, stepparent, spouse, sibling,
mother-in-law, father-in-law, son-in-law, daughter-in-law, brother-in-law or sister-in-law, and any person (other than a tenant or employee) sharing the household with the executive officer, director or 5% beneficial owner.

Transactions with Related Persons

Except as otherwise described in this Annual Report on Form 10-K, as amended, we are not now, nor have we been since the beginning of 2009, party to any transaction or series of similar transactions in
which the amount involved exceeded or exceeds $120,000 and in which any director, executive officer, holder of more than 5% of our Common Stock or any member of the immediate family of any of the foregoing persons had or will have a direct or
indirect material interest.

Director Independence

In accordance with the rules and regulations of the Nasdaq Stock Market LLC, our Board of Directors affirmatively determines the independence of each director and nominee for election as a director in
accordance with guidelines it has adopted, which include all elements of independence under the definition promulgated by the Nasdaq Stock Market LLC.

Based on these standards, the Board of Directors has determined that each of the following non-employee directors is an independent director as defined by the Nasdaq Stock Market LLC and has
no relationship with us, except as a director and/or stockholder: Mr. Dalziel, Mr. Davis, Dr. Hart, Dr. Loren and Ms. Williams.



26



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##### Table of Contents

|Item 14. | PRINCIPAL ACCOUNTANT FEES AND SERVICES
|-------- | --------------------------------------

Audit and Non-Audit Fees

The following table presents fees for professional audit services rendered by Grant Thornton LLP for the audit of our annual consolidated
financial statements for the years ended December 31, 2009 and December 31, 2010, respectively, and fees billed for other services rendered by Grant Thornton LLP during those respective periods.



|                   |  |      |         |  |      |   |         | 
|------------------ |  | ---- | ------- |  | ---- | - | ------- | 
|                   |  | 2009 |         |  | 2010 |  
|Audit fees         |  | $    | 610,249 |  |      | $ | 436,782 | 
|Audit-related fees |  |      | 0       |  |      |   | 0       | 
|Tax fees           |  |      | 0       |  |      |   | 0       | 
|All other fees     |  |      | 0       |  |      |   | 0       | 
|                   |  |      |         |  |      |   |         | 
|Total              |  | $    | 610,249 |  |      | $ | 436,782 | 
|                   |  |      |         |  |      |   |         | 

Audit Fees

Fees incurred by us for professional services rendered by Grant Thornton LLP for the audit of the annual consolidated financial statements included in our Annual Report on Form 10-K, for the reviews of
the consolidated financial statements included in our Quarterly Reports on Form 10-Q and for the audit of internal control over financial reporting required under the Sarbanes-Oxley Act of 2002 were $610,249 and $436,782 for 2009 and 2010,
respectively.

Audit-Related Fees

We paid no audit-related fees to Grant Thornton LLP in 2009 and 2010.

Tax Fees

We paid no fees associated with tax compliance and tax consultation to Grant Thornton LLP in 2009 and 2010.

All Other Fees

We paid no other fees to Grant Thornton LLP in 2009 and 2010.

Policy on Audit Committee
Pre-Approval of Audit and Permissible Non-Audit Services of Independent Registered Public Accounting Firm

Consistent with
the policies of the Securities and Exchange Commission regarding auditor independence, the Audit Committee has responsibility, pursuant to its written charter, for appointing, setting compensation and overseeing the work of our independent
registered public accounting firm. In recognition of this responsibility, the Audit Committee has established a policy to pre-approve all audit and permissible non-audit services provided by our independent registered public accounting firm. The
Audit Committees policy is to approve all audit and non-audit services provided by our independent registered public accounting firm prior to the commencement of the services using a combination of pre-approvals for certain engagements up to
predetermined dollar thresholds in accordance with the pre-approval policy and specific approvals for certain engagements on a case-by-case basis. The Audit Committee has delegated authority to the committee chair to pre-approve between committee
meetings those services that have not already been pre-approved by the committee. The chair is required to report any such pre-approval decisions to the full committee at its next scheduled meeting.



27



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##### Table of Contents

PART IV



|Item 15. | EXHIBITS, FINANCIAL STATEMENT SCHEDULES
|-------- | ---------------------------------------

(1) Financial Statements.

Item 15(1) is not being amended by this Amendment No. 1 to Annual Report on Form 10-K/A, and no financial statements are being
filed with this Amendment No. 1 to Annual Report on Form 10-K/A. Please see Item 15(1) of our Annual Report on Form 10-K for the year ended December 31, 2010, which we filed with the SEC on March 15, 2011.

(2) Financial Statement Schedules.

Item 15(2) is not being amended by this Amendment No. 1 to Annual Report on Form 10-K/A, and no financial statement schedules are being filed with this Amendment No. 1 to Annual Report on
Form 10-K/A. Please see Item 15(2) of our Annual Report on Form 10-K for the year ended December 31, 2010, which we filed with the SEC on March 15, 2011.

(3) Exhibits.

The following is a list of exhibits filed as part of this
Amendment No. 1 to Annual Report on Form 10-K/A.



|              |  |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
|------------- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|ExhibitNumber |  | Description                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
|              | 
|2.1(1)        |  | Agreement and Plan of Merger, dated April 5, 2011, by and among Laboratory Corporation of America Holdings, OCM Acquisition Corp., and the Registrant (filed as Exhibit
2.1).                                                                                                                                                                                                                                                                                                                                                                                                                                            
|              | 
|3.1(2)        |  | Restated Certificate of Incorporation of the Registrant, dated May 10, 2000 (filed as Exhibit 3.1).                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
|              | 
|3.2(2)        |  | Certificate of Amendment to the Restated Certificate of Incorporation of the Registrant, dated June 12, 2001 (filed as Exhibit 3.2).                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
|              | 
|3.3(2)        |  | Certificate of Amendment to the Restated Certificate of Incorporation of the Registrant, dated June 14, 2002 (filed as Exhibit 3.3).                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
|              | 
|3.4(3)        |  | Certificate of Amendment to the Restated Certificate of Incorporation of the Registrant, dated March 30, 2004 (filed as Exhibit 4.10).                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
|              | 
|3.5(3)        |  | Certificate of Amendment to the Restated Certificate of Incorporation of the Registrant, dated June 14, 2005 (filed as Exhibit 4.11).                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|              | 
|3.6(2)        |  | Certificate of Designation, Preferences, and Rights of Series A Junior Participating Preferred Stock of the Registrant, dated August 1, 2001 (filed as Exhibit 3.4).                                                                                                                                                                                                                                                                                                                                                                                                                                                     
|              | 
|3.7(4)        |  | Certificate of Designations, Preferences and Rights of Series A Convertible Preferred Stock of the Registrant, dated March 31, 2003 (filed as Exhibit 3.1).                                                                                                                                                                                                                                                                                                                                                                                                                                                              
|              | 
|3.8(5)        |  | Third Amended and Restated Bylaws of the Registrant (filed as Exhibit 3.1).                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
|              | 
|4.1(6)        |  | Specimen certificate for share of common stock (filed as Exhibit 4.1).                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
|              | 
|4.2(7)        |  | Rights Agreement, dated as of July 27, 2001, by and between the Registrant and American Stock Transfer & Trust Company, which includes the form of Certificate of Designation
setting forth the terms of the Series A Junior Participating Preferred Stock, $0.001 par value, as Exhibit A, the form of rights certificate as Exhibit B and the summary of rights to purchase Series A Junior Participating Preferred Stock as Exhibit
C. Pursuant to the Rights Agreement, printed rights certificates will not be mailed until after the Distribution Date (as defined in the Rights Agreement) (filed as Exhibit 4.1).
|              | 
|4.3(4)        |  | First Amendment to Rights Agreement by and between the Registrant and American Stock Transfer & Trust Company, as rights agent, dated as of March 31, 2003 (filed as Exhibit
10.3).                                                                                                                                                                                                                                                                                                                                                                                                                                      



28



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##### Table of Contents

|              |  |                                                                                                                                                                                                                                 
|------------- |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|ExhibitNumber |  | Description                                                                                                                                                                                                                     
|              | 
|4.4(1)        |  | Second Amendment, dated April 5, 2011, to Rights Agreement, dated as of July 27, 2001, as amended on March 31, 2003, between the Registrant and American Stock Transfer & Trust
Company, as rights agent (filed as Exhibit 4.1).
|              | 
|10.1(8)     |  | 1995 Stock Incentive Plan, as amended, including form of stock option certificate for incentive and non-statutory stock options (filed as Exhibit 10.1).                                                                        
|              | 
|10.2(8)     |  | 2000 Employee, Director, Consultant Stock Plan, including form of stock option agreement for non-statutory and incentive stock options (filed as Exhibit 10.2).                                                                 
|              | 
|10.3(9)     |  | The Amended and Restated 2005 Stock Plan and the form of stock option agreement for non-statutory and incentive stock options (filed as Exhibits 99.1, 99.2 and 99.3,
respectively).                                            
|              | 
|10.4(8)     |  | Executive Benefit Program, including Executive Deferred Compensation Plan and Executive Severance Plan (filed as Exhibit 10.3).                                                                                                 
|              | 
|10.5(10)    |  | Lifecodes Corporation 1992 Employee Stock Option Plan (filed as Exhibit 99.2).                                                                                                                                                  
|              | 
|10.6(10)    |  | Lifecodes Corporation 1995 Employee Stock Option Plan (filed as Exhibit 99.3).                                                                                                                                                  
|              | 
|10.7(10)    |  | Lifecodes Corporation 1998 Stock Plan (filed as Exhibit 99.4).                                                                                                                                                                  
|              | 
|10.8(11)     |  | Commercial Services Agreement effective September 17, 2001 between the Registrant and the Department of Environment, Food and Rural Affairs (filed as Exhibit
10.22).                                                           
|              | 
|10.9(11)     |  | Amended Patent Assignment and License Agreement dated July 7, 2003 by and between the Registrant, GeneCo Pty Ltd, Diatech Pty Ltd and Queensland University of Technology (filed as
Exhibit 10.25).                             
|              | 
|10.10(11)    |  | Exclusive Patent License Agreement dated October 1, 2003 between the Registrant and Saint Louis University (filed as Exhibit 10.26).                                                                                            
|              | 
|10.11(11)    |  | Settlement Agreement dated August 6, 2002 between the Registrant and Saint Louis University (filed as Exhibit 10.27)                                                                                                            
|              | 
|10.12(11)     |  | Amendment No. 1 to Settlement Agreement dated October 1, 2003 between the Registrant and Saint Louis University (filed as Exhibit 10.28).                                                                                       
|              | 
|10.13(12)   |  | Director Compensation Policy, effective January 1, 2004 (filed as Exhibit 10.18).                                                                                                                                               
|              | 
|10.14(13)     |  | NWI Lease Agreement between the Registrant and NWI Warehouse Group L.P. dated February 15, 1996 for the facility located at 1400 Donelson Pike, Suite A-15, Nashville,
Tennessee, 37217 (filed as Exhibit 10.1).                
|              | 
|10.15(13)     |  | Lease Agreement Amendment No. 1 between the Registrant and Duke-Weeks Realty L.P. dated January 23, 2001 for the facility located at 1400 Donelson Pike, Suite A-15, Nashville,
Tennessee, 37217 (filed as Exhibit 10.2).       
|              | 
|10.16(13)     |  | Lease Agreement Amendment No. 2 between the Registrant and Duke Realty Limited Partnership dated August 8, 2005 for the facility located at 1400 Donelson Pike, Suite A-15,
Nashville, Tennessee, 37217 (filed as Exhibit 10.3).
|              | 
|10.17(13)     |  | Lease Agreement between the Registrant and Valwood Service Center I, Ltd. effective October 15, 2005 for the facility located at 13988 Diplomat Drive, Suite 100, Farmers Branch,
Texas, 75234 (filed as Exhibit 10.4).         
|              | 
|10.18(13)     |  | Lease Agreement between the Registrant and Valwood Service Center I, Ltd. effective December 15, 2005 for the facility located at 13988 Diplomat Drive, Suite 100, Farmers Branch,
Texas, 75234 (filed as Exhibit 10.5).        



29



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##### Table of Contents

|              |  |                                                                                                                                                                                                    
|------------- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|ExhibitNumber |  | Description                                                                                                                                                                                        
|              | 
|10.19(14)   |  | Employment Agreement dated March 8, 2006 between the Registrant and Thomas A. Bologna (filed as Exhibit 99.1).                                                                                     
|              | 
|10.20(15)     |  | Letter Agreement by and between College Road Associates, Limited Partnership and the Registrant, dated January 18, 2005 (filed as Exhibit 10.27).                                                  
|              | 
|10.21(15)     |  | Amendment No. 1 to Lease Agreement by and between Bellemead Development Corporation and the Registrant, dated November 1, 2005 (filed as Exhibit 10.28).                                           
|              | 
|10.22(15)    |  | Letter Agreement and Product Loan Agreement between the Registrant and Applied Biosystems, dated January 5, 2006 (filed as Exhibit 10.30).                                                         
|              | 
|10.23(16)   |  | Addendum to Employment Agreement dated March 8, 2006 between the Registrant and Thomas A. Bologna (filed as Exhibit 10.33).                                                                        
|              | 
|10.24(12)   |  | Employment Agreement dated as of October 5, 2007 between the Registrant and James F. Smith (filed as Exhibit 10.31).                                                                               
|              | 
|10.25(12)   |  | Employment Agreement dated as of November 19, 2007 between the Registrant and William J. Thomas (filed as Exhibit 10.33).                                                                          
|              | 
|10.26(17)   |  | Employment Agreement dated as of May 13, 2008 between the Registrant and Jeffrey S. Boschwitz (filed as Exhibit 10.1).                                                                             
|              | 
|10.27(18)     |  | Lease Agreement dated December 15, 2009 between Duft Enterprises Corp. and the Registrant for the facility located at 635 Columbia St., New Westminster, British Columbia (filed as
Exhibit 10.27).
|              | 
|10.28(19)   |  | Executive Compensation Program (filed as Exhibit 10.28).                                                                                                                                           
|              | 
|21.1(19)      |  | Subsidiaries of the Registrant (filed as Exhibit 21.1).                                                                                                                                            
|              | 
|23.1(19)      |  | Consent of Grant Thornton LLP (filed as Exhibit 23.1).                                                                                                                                             
|              | 
|31.1(19)      |  | Certification of Principal Executive Officer dated March 15, 2011 pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 (filed as Exhibit 31.1).                                               
|              | 
|31.1.1        |  | Certification of Principal Executive Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 (filed herewith).                                                                           
|              | 
|31.2(19)      |  | Certification of Principal Financial and Accounting Officer dated March 15, 2011 pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 (filed as Exhibit 31.2).                                
|              | 
|31.2.1        |  | Certification of Principal Financial and Accounting Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 (filed herewith).                                                            
|              | 
|32.1(19)      |  | Certifications of Principal Executive Officer and Principal Financial and Accounting Officer pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 (filed as Exhibit
32.1).                    
|              | 
|99.1(20)      |  | Settlement Agreement dated September 3, 2010 between the Registrant and Accipiter Capital Management, LLC (filed as Exhibit 10.1).                                                                 



| | Portions of this Exhibit were omitted and have been filed separately with the Secretary of the SEC pursuant to the Registrants application requesting confidential
treatment thereof.
|- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | Management or compensatory plan.
|-- | --------------------------------



30



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##### Table of Contents

|(1) | Previously filed with the SEC as Exhibits to, and incorporated herein by reference from, the Registrants Current Report on Form 8-K as filed with the SEC on
April 6, 2011 (File No. 000-30267).
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | Previously filed with the SEC as Exhibits to, and incorporated herein by reference from, the Registrants Quarterly Report on Form 10-Q for the period ended
June 30, 2002 as filed with the SEC on August 14, 2002 (File No. 000-30267).
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(3) | Previously filed with the SEC as Exhibits to, and incorporated herein by reference from, the Registrants registration statement on Form S-8 as filed with the SEC
on June 29, 2005 (File No. 333-126227).
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(4) | Previously filed with the SEC as Exhibits to, and incorporated herein by reference from, the Registrants Current Report on Form 8-K as filed with the SEC on
April 2, 2003 (File No. 000-30267).
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(5) | Previously filed with the SEC as an Exhibit to, and incorporated herein by reference from, the Registrants Current Report on Form 8-K as filed with the SEC on
September 7, 2007 (File No. 000-30267).
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(6) | Previously filed with the SEC as an Exhibit to, and incorporated herein by reference from, the Registrants Quarterly Report on Form 10-Q for the period ended
September 30, 2001 as filed with the SEC on November 14, 2001 (File No. 000-30267).
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(7) | Previously filed with the SEC as an Exhibit to, and incorporated herein by reference from, the Registrants registration statement on Form 8-A as filed with the
SEC on August 3, 2001 (File No. 000-30267).
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(8) | Previously filed with the SEC as Exhibits to, and incorporated herein by reference from, the Registrants registration statement on Form S-1, as amended, as
originally filed with the SEC on February 18, 2000 (File No. 333-30774).
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(9) | Previously filed with the SEC as Exhibits to, and incorporated herein by reference from, the Registrants Current Report on Form 8-K as filed with the SEC on
June 14, 2005 (File No. 000-30267).
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(10) | Previously filed with the SEC as Exhibits to, and incorporated herein by reference from, the Registrants registration statement on Form S-8 as filed with the SEC
on January 15, 2002 (File No. 333-76744).
|---- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(11) | Previously filed with the SEC as Exhibits to, and incorporated herein by reference from, the Registrants Annual Report on Form 10-K for the year ended
December 31, 2003 as filed with the SEC on March 29, 2004 (File No. 000-30267).
|---- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(12) | Previously filed with the SEC as Exhibits to, and incorporated herein by reference from, the Registrants Annual Report on Form 10-K for the year ended
December 31, 2007 as filed with the SEC on March 12, 2008 (File No. 000-30267).
|---- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(13) | Previously filed with the SEC as Exhibits to, and incorporated herein by reference from, the Registrants Quarterly Report on Form 10-Q for the period ended
September 30, 2005 as filed with the SEC on November 9, 2005 (File No. 000-30267).
|---- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(14) | Previously filed with the SEC as an Exhibit to, and incorporated herein by reference from, the Registrants Current Report on Form 8-K as filed with the SEC on
March 9, 2006 (File No. 000-30267).
|---- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(15) | Previously filed with the SEC as Exhibits to, and incorporated herein by reference from, the Registrants Annual Report on Form 10-K for the year ended
December 31, 2005 as filed with the SEC on May 24, 2006 (File No. 000-30267).
|---- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(16) | Previously filed with the SEC as Exhibits to, and incorporated herein by reference from, the Registrants Annual Report on Form 10-K for the year ended
December 31, 2006 as filed with the SEC on March 15, 2007 (File No. 000-30267).
|---- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(17) | Previously filed with the SEC as an Exhibit to, and incorporated herein by reference from, the Registrants Quarterly Report on Form 10-Q for the period ended June
30, 2008 as filed with the SEC on August 1, 2008 (File No. 000-30267).
|---- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(18) | Previously filed with the SEC as an Exhibit to, and incorporated herein by reference from, the Registrants Annual Report on Form 10-K for the year ended
December 31, 2009 as filed with the SEC on March 12, 2010, as amended (File No. 000-30267).
|---- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(19) | Previously filed with the SEC as an Exhibit to, and incorporated herein by reference from, the Registrants Annual Report on Form 10-K for the year ended
December 31, 2010 as filed with the SEC on March 15, 2011 (File No. 000-30267).
|---- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(20) | Previously filed with the SEC as an Exhibit to, and incorporated herein by reference from, the Registrants Current Report on Form 8-K as filed with the SEC on
September 8, 2010 (File No. 000-30267).
|---- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



31



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##### Table of Contents

SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this
report to be signed on its behalf by the undersigned, thereunto duly authorized.



|                     |  |                      |  |                                                                                        
|-------------------- |  | -------------------- |  | ---------------------------------------------------------------------------------------
|                     |  | ORCHID CELLMARK INC.
|                     |  |                     
|Date: April 29, 2011 |  | By:                  |  | /s/    James F. Smith                                                                  
|                     |  |                      |  | James F. Smith                                                                         
|                     |  |                      |  | Vice President and Chief Financial Officer
(Principal Financial and Accounting Officer)



32