[Federal Register Volume 74, Number 140 (Thursday, July 23, 2009)]
[Notices]
[Pages 36493-36494]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: E9-17527]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Agency for Toxic Substances and Disease Registry

[ATSDR-254]


Notice of Development of Set 23 Toxicological Profiles

AGENCY: Agency for Toxic Substances and Disease Registry (ATSDR), 
Department of Health and Human Services (HHS).

ACTION: Notice.

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SUMMARY: This notice announces the development of Set 23 Toxicological 
Profiles. Set 23 Toxicological Profiles consists of three new drafts 
and two updated drafts. These profiles will be available to the public 
on or about October 17, 2009. Electronic access to these documents will 
be available at the ATSDR Web site: http://www.atsdr.cdc.gov/toxpro2.html.

Set 23 Toxicological Profiles

    The following toxicological profiles are now being developed:

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            Toxicological profile                                           CAS No.
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1. Acrylamide*...............................  79-06-1
2. Carbon Monoxide*..........................  630-08-0
3. 1,3-Butadiene.............................  106-99-0
4. Phosphate Ester Flame Retardants*.........  126-73-8, 126-71-6, 78-51-3, 115-86-6, 13674-84-5, 13674-87-8,
                                                115-96-8
5. Vanadium..................................  7440-62-2
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* Denotes new profile.


SUPPLEMENTARY INFORMATION: The Superfund Amendments and Reauthorization 
Act of 1986 (SARA) (42 U.S.C. 9601 et seq.) amended the Comprehensive 
Environmental Response, Compensation, and Liability Act of 1980 (CERCLA 
or Superfund) (42 U.S.C. 9601 et seq.) by establishing certain 
requirements for ATSDR and the U.S. Environmental Protection Agency 
(EPA) with regard to hazardous substances that are most commonly found 
at facilities on the CERCLA National Priorities List (NPL). Among these 
statutory requirements is a mandate for the Administrator of ATSDR to 
prepare toxicological profiles for each substance included on the 
Priority List of Hazardous Substances (http://www.atsdr.cdc.gov/cercla/07list.html). This list names 275 hazardous substances that pose the 
most significant potential threat to human health as determined by 
ATSDR and EPA. The availability of the revised list of the 275 priority 
substances was announced in the Federal Register on March 6, 2008 (73 
FR 12178). For prior versions of the list of substances, see Federal 
Register notices dated April 17, 1987 (52 FR 12866); October 20, 1988 
(53 FR 41280); October 26, 1989 (54 FR 43619); October 17, 1990 (55 FR 
42067); October 17, 1991 (56 FR 52166); October 28, 1992 (57 FR 48801); 
February 28, 1994 (59 FR 9486); April 29, 1996 (61 FR 18744; November 
17, 1997 (62 FR 61332); October 21, 1999 (64 FR 56792); October 25, 
2001 (66 FR 54014); November 7, 2003 (68 FR 63098); and December 7, 
2005 (70 FR 70284).
    The Set 23 Toxicological Profiles for 1,3-Butadiene and Vanadium 
are updates of previously published profiles for NPL priority 
substances. In addition, to address emerging public health concerns 
related to substances not currently on the NPL, ATSDR is also 
developing Set 23 Toxicological Profiles for Carbon Monoxide, 
Acrylamide, and Phosphate Ester Flame Retardants. Carbon monoxide is a 
toxic gas produced from the incomplete combustion of carbon-based 
fuels. Because it is colorless and odorless, toxicity can occur with no 
indication that exposure is occurring. Thousands of hospitalizations 
and hundreds of deaths occur every year as a result of inadvertent 
exposure to carbon monoxide. Acrylamide is a known animal carcinogen 
that is widely used in industry to synthesize polyacrylamides. 
Acrylamide also occurs naturally in a few foods, is formed in many 
foods as a byproduct of numerous cooking processes, and has been 
detected recently in human biomonitoring studies. Phosphate ester flame 
retardants comprise a large group of structurally related chemicals 
with increasing uses in clothing, fabrics, furniture, and structural 
components. However, there is an increasing body of information 
regarding exposures, body burdens, and toxicity related to this group 
of chemicals.

[[Page 36494]]

    Notice of the availability of drafts of these two updated and three 
new toxicological profiles for public review and comment will be 
published in the Federal Register on/or about October 17, 2009, with 
notice of a 90-day public comment period for each profile, starting 
from the actual release date. Following the close of the comment 
period, chemical-specific comments will be addressed, and, where 
appropriate, changes will be incorporated into each profile.

FOR FURTHER INFORMATION CONTACT: Commander Jessilynn B. Taylor, 
Division of Toxicology and Environmental Medicine, Agency for Toxic 
Substances and Disease Registry, 1600 Clifton Road, NE., Mail Stop F-
32, Atlanta, GA 30333, telephone 770-488-3313.

Ken Rose,
Director, Office of Policy, Planning and Evaluation, National Center 
for Environmental Health/Agency for Toxic Substances and Disease 
Registry.
[FR Doc. E9-17527 Filed 7-22-09; 8:45 am]
BILLING CODE 4163-70-P