SECURITIES AND EXCHANGE COMMISSIONWashington, D.C. 20549

FORM 10-Q



|[X] | QUARTERLY
        REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT
    OF 1934 FOR THE QUARTERLY PERIOD ENDED SEPTEMBER 30, 2008
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------

OR

|[   ] | TRANSITION
    REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE EXCHANGE ACT
|----- | -------------------------------------------------------------------------

COMMISSION FILE NO. 333-134987

TETRAGENEXPHARMACEUTICALS,INC.
(NAMEOFSMALLBUSINESSISSUERINITSCHARTER)

|DELAWARE                                |  | 0-2834                              |  | 22-3781895      
|--------------------------------------- |  | ----------------------------------- |  | ----------------
|(State or other jurisdiction
        of |  | (Primary Standard Industrial        |  | (I.R.S. Employer
|incorporation or organization)          |  | Classification Code
        Number) |  | I.D. No.)       

1 Maynard Drive Suite 105Park Ridge, New Jersey 07656(Address of Principal Executive Offices)(201) 505-1300(Issuers Telephone Number)

Indicate by check mark whether the issuer: 1) has filed
all reports required to be filed by Section 13 or 15(d) of the Securities Exchange
Act of 1934 during the preceding 12 months (or for such shorter period that the
 registrant was required to file such reports); and 2) has been subject to such
filing requirements for the past 90 days. YesþNoo

Indicate
  by check mark whether the Registrant is a large accelerated filer, an  accelerated
  filer, a non-accelerated filer, or a smaller reporting company. See the definitions
  of  large accelerated filer, accelerated filer and smaller
  reporting company in Rule 12b-2 of the Exchange Act.

|Large accelerated filero |  | Accelerated filero        
|------------------------ |  | --------------------------
|Non-accelerated filero   |  | Smaller reporting companyþ

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).oYesþNo

APPLICABLE ONLY TO ISSUERS INVOLVED
    IN BANKRUPTCY PROCEEDINGS DURING THE PRECEDING FIVE YEARS:

Indicate by check
  mark whether the registrant has filed all documents and reports required
  to be filed by Section 12, 13 or 15(d) of the Securities Exchange Act of
  1934 subsequent to the distribution of securities under a plan confirmed
  by a court. 
  YesþNoo

Number of shares outstanding of registrants common stock, $0.001 par value, outstanding on November 14, 2008: 15,926,126

---



TABLE OF CONTENTS

|PART I: FINANCIAL INFORMATION |                                                            | 
|----------------------------- | ---------------------------------------------------------- | 
|                              |                                                            | 
|ITEM 1.                       | FINANCIAL STATEMENTS                                       | 
|                              |                                                            | 
|ITEM 2.                       | MANAGEMENTS DISCUSSION AND ANALYSIS OF FINANCIAL          | 
|                              | CONDITION AND PLAN OF OPERATIONS                           | 
|                              |                                                            | 
|ITEM 3.                       | QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK | 
|                              |                                                            | 
|ITEM 4(T)                     | CONTROLS AND PROCEDURES                                    | 
|                             
|PART II: OTHER INFORMATION    |                                                            | 
|                              |                                                            | 
|ITEM 1.                       | LEGAL PROCEEDINGS                                          | 
|                              |                                                            | 
|ITEM 2.                       | UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF         | 
|                              | PROCEEDS                                                   | 
|                              |                                                            | 
|ITEM 3.                       | DEFAULTS ON SENIOR SECURITIES                              | 
|                              |                                                            | 
|ITEM 4.                       | SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS        | 
|                              |                                                            | 
|ITEM 5.                       | OTHER INFORMATION                                          | 
|                              |                                                            | 
|ITEM 6.                       | EXHIBITS                                                   | 
|                              |                                                            | 
|SIGNATURES                    |                                                            | 

i

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PART I: FINANCIAL INFORMATION

ITEM 1.     FINANCIAL STATEMENTS

Index to Financial Statements

|                                                                                           |  | Page
|------------------------------------------------------------------------------------------ |  | ----
|Unaudited Condensed Balance Sheet as of September 30, 2008 and Audited Balance Sheet as of |  |     
|December 31, 2007                                                                          |  | F-1 
|                                                                                           |  |     
|Unaudited Condensed Statement of Operations for the Three and Nine Month Periods           |  |     
|Ended Septemer 30, 2008 and 2007                                                           |  | F-2 
|                                                                                           |  |     
|Unaudited Condensed Statement of Cash Flows for the Nine Month Periods Ended September 30, |  |     
|2008 and 2007                                                                              |  | F-3 
|                                                                                           |  |     
|Notes to Unaudited Condensed Financial Statements                                          |  | F-4 

1

The Accompanying Notes are an Integral Part of the Financial Statements

---



Unaudited Condensed Balance Sheetas of September 30, 2008 andAudited Balance Sheetas of December 31, 2007

|                                                              |  | December |              | September |            
|------------------------------------------------------------- |  | -------- | ------------ | --------- | -----------
|ASSETS                                                        |  | 31, 2007 |              | 30, 2008  |            
|                                                              |  |          |              |           | (unaudited)
|Current assets                                                |  |          |              |           |            
|Cash and cash equivalents                                     |  | $        | 527,737      |           | $          
|Prepaid insurance and other current assets                    |  |          | 33,777       |           |            
|                                                              |  |          | 561,514      |           |            
|                                                             
|Property and equipment, net                                   |  |          | 4,188        |           |            
|Security Deposit                                              |  |          | 18,958       |           |            
|Patents, net                                                  |  |          | 429,268      |           |            
|                                                              |  | $        | 1,013,928    |           | $          
|                                                             
|LIABILITIES AND STOCKHOLDERS' EQUITY                          |  |          |              |           |            
|                                                             
|Current liabilities                                           |  |          |              |           |            
|Accounts payable and accrued expenses                         |  |          | 1,153,639    |           |            
|Accrued interest                                              |  |          | 178,828      |           |            
|Notes Payable                                                 |  |          | -            |           |            
|                                                             
|                                                             
|Total current
liabilities                                     |  |          | 1,332,467    |           |            
|                                                             
|Long term liability                                           |  |          |              |           |            
|                                                             
|Notes payable                                                 |  |          | 1,882,362    |           |            
|                                                             
|Total liabilities                                             |  |          | 3,214,829    |           | $          
|                                                             
|Commitments and contingencies                                 |  |          |              |           |            
|                                                             
|Stockholders' equity (deficit)                                |  |          |              |           |            
|Class A preferred stock - $.01 par value - 5,000,000          |  |          |              |           |            
|shares authorized; 0 shares
outstanding                       |  |          | -            |           |            
|Common stock - $.001 par value - 50,000,000 shares authorized |  |          |              |           |            
|15,926,126 shares issued and
outstanding                      |  |          | 15,926       |           |            
|                                                             
|Additional paid-in capital                                    |  |          | 101,775,845  |           |            
|Accumulated deficit                                           |  |          | (103,992,672 | )         |            
|                                                             
|Total stockholders' (deficit)                                 |  |          | (2,200,901   | )         |            
|                                                              |  | $        | 1,013,928    |           | $          

F-1

The Accompanying Notes are an Integral Part of the Financial Statements

---



Unaudited Condensed Statement of Operationsfor the Three and Nine-Month Periods Ended September 30, 2008 and 2007

|                                            |  | Three
        months ended September 30, |            | Nine
        months ended September 30, |  
|------------------------------------------- |  | ---------------------------------------- | ---------- | --------------------------------------- | -
|                                            |  | 2008                                     |            | 2007                                    |  
|                                            |  | (unaudited)                              |            | (unaudited)                             |  
|Revenue                                     |  |                                          |            |                                         |  
|Contract
        revenue                    |  | $                                        | -          |                                         | $
|                                            |  |                                          | -          |                                         |  
|                                           
|Operating expenses                          |  |                                          |            |                                         |  
|Research
        and development            |  |                                          | -          |                                         | $
|Compensation
        expense                |  |                                          | 239,838    |                                         |  
|Travel                                      |  |                                          | 8,079      |                                         |  
|General
        and administrative          |  |                                          | 47,486     |                                         |  
|Professional
        fees                   |  |                                          | 5,931      |                                         |  
|Payroll
        taxes and employee benefits |  |                                          | 17,789     |                                         |  
|Consulting
        fees                     |  |                                          | -          |                                         |  
|Rent
        and occupancy                  |  |                                          | 22,982     |                                         |  
|Depreciation
        and amortization       |  |                                          | 11,659     |                                         |  
|                                           
|Loss before other income (expense)          |  |                                          | (353,764   | )                                       |  
|Other income (expense)                      |  |                                          |            |                                         |  
|Interest
        income and other           |  |                                          | 432        |                                         |  
|Interest
        expense                    |  |                                          | (30,028    | )                                       |  
|Net loss                                    |  | $                                        | (383,360   | )                                       | $
|                                           
|Basic and diluted net loss per share        |  | $                                        | (0.02      | )                                       | $
|                                           
|Weighted average common shares outstanding  |  |                                          | 15,926,126 |                                         |  

F-2

The Accompanying Notes are an Integral Part of the Financial Statements

---



Unaudited Condensed Statement of Cash Flowsfor the Nine-Month Periods Ended September 30, 2008 and 2007

|                                                            |  | Nine
    months ended September 30, |           
|----------------------------------------------------------- |  | ----------------------------------- | ----------
|                                                            |  | 2008                                |           
|                                                            |  | (unaudited)                         |           
|Cash flows from operating
          activities              |  |                                     |           
|Net
        loss                                            |  | $                                   | (1,154,504
|                                                            |  |                                     |           
|Adjustments
          to reconcile net loss to net cash     |  |                                     |           
|used
          in operating activities                      |  |                                     |           
|Depreciation
    and amortization                           |  |                                     | 33,557    
|Amortization
        of debt discount                       |  |                                     | 10,720    
|Stock,
        option and warrant compensation              |  |                                     | -         
|Changes
          in operating assets and liabilities       |  |                                     |           
|Prepaid
        insurance and other current assets          |  |                                     | 20,176    
|Accounts
    payable and accrued expenses                   |  |                                     | 566,072   
|Accrued
    interest payable                                |  |                                     | 51,996    
|Net cash used in operating activities                       |  |                                     | (471,983  
|                                                           
|Cash flows from investing
          activities              |  |                                     |           
|Cash
        paid for property and equipment                |  |                                     | (1,409    
|Patent
    cost                                             |  |                                     | (52,349   
|Net cash used in investing activities                       |  |                                     | (53,758   
|                                                           
|Cash flows from financing
          activities              |  |                                     |           
|Proceeds
        from notes payable                         |  |                                     | 250,000   
|Net cash provided by financing activities                   |  |                                     | 250,000   
|                                                            |  |                                     |           
|Net
    decrease in cash and cash equivalents               |  |                                     | (275,741  
|                                                            |  |                                     |           
|Cash
    and cash equivalents, beginning of year            |  |                                     | 527,737   
|                                                           
|Cash and cash equivalents,
          end of period          |  | $                                   | 251,996   
|                                                           
|Supplemental disclosures
          of cash flow information |  |                                     |           
|Cash
        paid for taxes                                 |  |                                     |           
|                                                           
|Non Cash Transactions                                       |  |                                     |           
|Stock,
        options, and warants issued for compensation |  |                                     | -         

F-3

The Accompanying Notes are an Integral Part of the Financial Statements

---



Notes to the Financial Statements

1. THE COMPANY

Tetragenex Pharmaceuticals Inc. (Tetragenex or the Company) was incorporated in 2000 in the State of Delaware while Innapharma, Inc., the Companys predecessor, was incorporated in 1989 also in
the State of Delaware (Innapharma). The corporate headquarters for Tetragenex are located in Park Ridge, New Jersey. On November 23, 2004 Innapharma merged into its then wholly owned subsidiary Tetragenex. As part of the merger all
existing shares, options and warrants of Innapharma converted into securities of Tetragenex on a 1-for-4 basis.

Tetragenex is a biopharmaceutical company working to discover, develop and commercialize proprietary pharmaceutical products that treat serious diseases for which current therapies are inadequate. Innapharma developed and
patented a novel platform of pharmaceutical small chain peptides that treat depression, anxiety and other central nervous system disorders, which were subsequently assigned to the Company upon the merger.  The Companys leading
product candidate, the antidepressant compound Nemifitide, is currently in human clinical trials.

Tetragenex has also discovered, synthesized and is currently developing a platform of new and unique chemically modified tetracycline molecules to be used in the treatment of certain types of cancer and treatment resistant
bacterial infections. These tetracycline-based product candidates are currently in the pre-clinical development stage.

2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

Going Concern and Liquidity

The Companys financial statements have been prepared assuming that the Company will continue as a going concern, which contemplates the realization of assets and the satisfaction of liabilities in the normal course of
business.  The Company incurred losses of $4,579,958 and $2,964,001 for years ended December 31, 2007 and 2006 respectively.  In addition at December 31, 2007 the Company had a working capital deficiency of $770,953, long term debt of
$1.8 million, which is now short term debt, and deficiency in stockholder equity of $2,200,901.  The Company has approximately seven months of working capital in the bank currently and its main source of funds has been private financings.
These factors raise doubt about the Companys ability to continue as a going concern. To address its liquidity concerns, on May 28, 2008, as part of a bridge financing, the Company issued promissory notes carrying 12% interest per annum having
an aggregate face value of $175,000, together with warrants to purchase an aggregate of 350,000 shares of the Companys common stock at $0.50 per share, to seven individuals. Further, on July 28, 2008, as part of the same bridge
financing, the Company issued promissory notes carrying 12% interest per annum having an aggregate face value of $75,000, together with warrants to purchase an aggregate of 150,000 shares of the Companys common stock at $0.50 per
share, to three individuals. The Companys low stock price and its continuing losses may make it difficult to obtain either equity or debt financing, and, there can be no assurances that additional financing which is necessary for the Company
to continue its business will be available to the Company on acceptable terms, or at all.  The Companys ability to continue its operations is dependent upon its ability to generate sufficient funds from financings to meet its obligations on a
timely basis and to further develop and market its products. The accompanying financial statements do not include any adjustments that might result from the outcome of these uncertainties.

F-4

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Recently Issued Accounting Standards

In June 2006, the FASB issued Interpretation No. 48, Accounting for Uncertainty in Income Taxes - An Interpretation of FASB Statement No. 109, (FIN 48). FIN 48 clarifies the accounting for uncertainty in income
taxes recognized in an enterprises financial statements in accordance with FASB Statement No. 109, Accounting for Income Taxes. FIN 48 also prescribes a recognition threshold and measurement attribute for the financial statement recognition
and measurement of a tax position taken or expected to be taken in a tax return that results in a tax benefit. Additionally, FIN 48 provides guidance on de-recognition, income statement classification of interest and penalties, accounting in interim
periods, disclosure, and transition. This interpretation is effective for fiscal years beginning after December 15, 2006. Tetragenex does not believe the application of FIN 48 to have a material affect on its financial statements.

In February 2007, the FASB issued SFAS No. 159, The Fair Value Option for Financial Assets and Financial Liabilities (SFAS No. 159). SFAS No. 159 allows companies to choose to measure certain
financial instruments and certain other items at fair value. The statement requires that unrealized gains and losses are reported in earnings for items measured using the fair value option and establishes presentation and disclosure requirements.
SFAS No. 159 is effective July 1, 2008 for the Company. The Company does not believe the adoption of SFAS No. 159 will have a material effect on our consolidated financial statements.

In June 2007, the FASB issued Emerging Issue Task Force (EITF) No. 07-03 (EITF 07-03),Accounting for Non-Refundable Advance Payments for Goods or Services to Be Used in Future Research
and Development Activities. EITF 07-03 provides guidance on whether non-refundable advance payments for goods that will be used or services that will be performed in future research and development activities
should be accounted for as research and development costs or deferred and capitalized until the goods have been delivered or the related services have been rendered. EITF 07-03 is effective for fiscal years beginning after December 15, 2007. The
Company does not believe that the adoption of EITF 07-03 will have a material impact on its financial position or results of operations.

In December 2007, the FASB issued SFAS No. 160, Noncontrolling Interests in Consolidated Financial Statements - an amendment of ARB No. 151. (SFAS 160). SFAS 160 requires all entities to report
noncontrolling (minority) interests in subsidiaries as equity in the consolidated financial statements. Its intention is to eliminate the diversity in practice regarding the accounting for transactions between an entity and noncontrolling interests.
This Statement is effective for the Company as of January 1, 2009. Earlier adoption is prohibited. The Company is currently assessing the impact, if any, of SFAS 160 on its consolidated financial statements.

In December 2007, the FASB issued SFAS No. 141R, Business Combinations (SFAS 141R). SFAS 141R provides guidance to improve the relevance, representational faithfulness, and comparability of the
information that a reporting entity provides in its financial reports about its business combinations and its effects. SFAS 141R establishes principles and requirements for how the acquirer recognizes and measures in its financial statements the
identifiable assets acquired, liabilities assumed, the goodwill acquired and determines what information to disclose to enable users of the financial statements to evaluate the nature and financial effects of the business combination. SFAS 141R is
effective for acquisitions beginning in our fiscal year beginning December 1, 2009 and earlier application is prohibited.

In May 2008, the FASB issued SFAS No. 162,The Hierarchy of Generally Accepted Accounting Principles(SFAS No. 162). This statement
identifies the sources of accounting principles and the framework for selecting the principles to be used in the preparation of financial statements of

F-5

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nongovernmental entities that are presented in conformity with generally accepted accounting principles in the United States (GAAP). This Statement shall be effective sixty days following the SECs approval
of the Public Company Accounting Oversight Board (PCAOB) amendments to AU Section 411, The Meaning of Present Fairly in Conformity With Generally Accepted Accounting Principles. The Company does not believe the adoption of SFAS No. 162
will have a material impact on its financial condition, results of operations or cash flows.

Interim Financial Statements

Financial statements for the three and nine month periods ended September 30, 2008 and 2007, have been prepared in accordance with US Generally Accepted Accounting Principles for interim financial information, and in the
opinion of the Companys management, reflect all adjustments, which include only normal recurring adjustments, necessary to present fairly the Companys financial position, results of operations and cash flows for the periods shown.  The
results of operations for such periods are not necessarily indicative of the results expected for a full year or for any future period.  The interim condensed financial statements should be read in conjunction with the audited financial statements
for the years ended December 31, 2007 and 2006 as appearing in the Companys form 10-KSB filed with the Securities and Exchange Commission on May 14, 2008, and as amended thereafter.

3. NOTES PAYABLE

The Company has outstanding promissory notes with an aggregate principal balance of $1,882,362, which carry 3% interest and are due on April 23, 2009. The notes are convertible into the Companys common stock at
$5 per share at the discretion of the holders of the notes. The notes are secured by the patents of the Company.

On May 28, 2008, as part of a bridge financing, the Company issued promissory notes carrying 12% interest per annum having an aggregate face value of $175,000, together with warrants to purchase 350,000 shares of the
Companys common stock at $0.50 per share, to seven individuals. The promissory notes shall be paid back the sooner of (i) upon their two year maturity date, or (ii) the Companys closing of financing equal to or greater than
$2,000,000, and they are convertible into securities issued in such financing at the holders discretion.

On July 28, 2008, as part of the same bridge financing, the Company issued promissory notes carrying 12% interest per annum having an aggregate face value of $75,000, together with warrants to purchase an aggregate of
150,000 shares of the Companys common stock at $0.50 per share, to three individuals. The promissory notes shall be paid back the sooner of (i) upon their two year maturity date, or (ii) the Companys closing of financing equal to or
greater than $2,000,000, and they are convertible into securities issued in such financing at the holders discretion. The Company recorded a debt discount related to the issuance of the promissory notes, of $20,232 and was amortizing
the discount over the term of the promissory notes. The amortization of the debt discount through September 30, 2008 was recorded as interest expense and amounted to $1,686. The warrants issued were valued by using the black scholes method. On
September 30, 2008 the Company had notes payable in the amount of $2,068,245

F-6

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4. STOCKHOLDERS EQUITY

Stock Options

All of the Companys outstanding options vest immediately. The options are not actively trading and the fair market value is not readily ascertainable, the options are taxable at the time of exercise as opposed to the
time of the grant.

On September 30, 2008 there were a total of 11,798,253 options outstanding all exercisable at $1 per share expiring between 2017 and 2020.

The following table presents, for each of the following classes of options, as determined by range of exercise price, the information regarding weighted-average exercise price and weighted average remaining contractual life
as of September 30, 2008:

Options Outstanding
      
      Options ExercisableWeighted
      Weighted
      
      
      Weighted
      WeightedRange of
      
      Average
      Average
      
      
      Average
      AverageExercise
      Number of
      Exercise
      Remaining
      
      Number of
      Exercise
      RemainingPrice
      Options
      Price
      Life
      
      Options
      Price
      Life$1.00
      11,798,253
      $1.00
      10
      
      11,798,253
      $1.00
      10


Warrants

On May 28, 2008, the Company issued promissory notes carrying 12% interest per annum having an aggregate face value of $175,000, together with warrants to purchase an aggregate of 350,000 shares of the Companys
common stock at $0.50 per share, to seven individuals.

Further and as part of the same financing, on July 28, 2008 the Company issued promissory notes carrying 12% interest per annum having an aggregate face value of $75,000, together with warrants to purchase an aggregate
of 150,000 shares of the Companys common stock at $0.50 per share, to three individuals.

At September 30, 2008, the Company had outstanding warrants to purchase 12,518,514 shares of the Companys common stock at exercise prices of $.50, $1, $1.30, $1.65 and $6 per share. These warrants
have expirations of July 2013, November 30, 2009, March 30, 2012, April 30, 2009 and November 30, 2011 respectively.

The following table presents, for each of the following classes of warrants as determined by range of exercise price, information regarding warrants outstanding and weighted-average exercise price as of September 30, 2008.

F-7

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Warrants OutstandingRange of Exercise
      
      Number of
      
      Weighted AveragePrice
      
      Warrants
      
      Exercise Price$1.00
      
      7,058,796
      
      
      $1.00$1.30
      
      1,030,000
      
      
      $1.30$1.65
      
      645,322
      
      
      $1.65$6.00
      
      3,284,396
      
      
      $6.00$0.50
      
      500,000
      
      
      $0.50


5. COMMON STOCK TRANSACTIONS

During the third quarter of 2008, the Company did not issue any shares of its common stock. On September 30, 2008 there were 15,926,126 common shares outstanding

At September 30, 2008, the Company had authorized 50,000,000 shares of common stock, $0.001 stated value. The following table represents the approximate allocation of reserved shares at September 30, 2008:

Common Stock
      15,926,126Stock Options
      11,798,253Warrants
      12,518,51440,242,893


6. EMPLOYMENT AGREEMENTS

Employment agreements

On December 15, 1999, the Company entered into a three-year
employment agreement with its co-Chief Executive Officer and Chairman of the
Board, Martin F. Schacker (Co-CEO). The agreement provided for an
annual  base salary of $160,000, subject to a minimum ten percent annual
increase. On February 6, 2001, in view of the executives efforts on behalf
of the Company and his performance, the Companys Board of Directors (i)
increased his annual  salary to $250,000 with no automatic annual increases,
and extended the term of his employment agreement for an additional two years,
and (ii) granted the executive a ten-year option to acquire 125,000 shares of
the Companys common stock
at an exercise price of $17 per share, one third of which vested immediately,
one third of which vested on February 6, 2002, and the final third vested on
February 6, 2003. On December 11, 2001, in consideration of services provided
to the  Company, the Board of Directors (i) further increased his annual salary
to $300,000, (ii) further extended the term of the agreement by one year,
through and including December 15, 2005 and (iii) granted the executive an additional,
immediately  vested five-year option to acquire 125,000 shares of the Companys
common stock at an exercise price of $17 per share. On April 6, 2003, as
a result of the Companys
cost reduction, the Co-CEO agreed to defer half of his
$300,000 yearly salary. In December 2005 the executive agreed to convert $177,000
of his deferred salary into options to purchase 177,000 shares of Tetragenex
common stock at $1 per share expiring December 20, 2020. In April 2008, the
Companys Board of Directors asked the Co-CEO to defer additional salary.
He is currently drawing a cash salary of $75,000 per year and the balance is
being deferred. At September 30, 2008 the executive had deferred compensation
totaling $478,413.
The Co-CEO is the nephew of the companys other Co-CEO David Abel.

F-8

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All officers, Directors and employees of the Company
at the time of the bankruptcy agreed to defer a portion or all of their compensation.
On September 30, 2008, there was $1,358,056 deferred from officers and employees
 and $206,250 from directors. It is anticipated that the majority of accrued
salaries will be converted into warrants of the Company on a 1-for-1 basis.

In April 2008 at the Boards request all salaried employees of the Company
 were subject  to a minimum of 50% temporary cash salary reduction while the
 Company sought financing for its operations. In October 2008, the Company ceased
 accruing salary reductions.

7. LITIGATION

At September 30, 2008 the Company was not involved in any ongoing litigation.

8. RISKS AND UNCERTAINTIES

The Company is subject to risks common to companies in the biopharmaceutical industry, including, but not limited to risks associated with the commercialization of product candidates, protection of proprietary technology
and compliance with Food and Drug Administration regulations.

As reflected in the accompanying consolidated financial statements, the Company has incurred significant recurring losses from operations and negative operating cash flows, which have been financed primarily by proceeds
from stock and debt issuances. As a result, the Company had an accumulated deficit of $105,147,176 and $103,992,672 at September 30, 2008 and 2007, respectively.

The Company plans to provide for additional working capital and funds for the continued development of its products through private or public sales of its common stock. The Companys ability to obtain such financing is
contingent upon continued progress in its drug development efforts and its ability to access capital resources. The Company is also attempting to enter into an agreement with a major pharmaceutical company to co-develop its antidepressant drug,
which may generate significant cash flows for the Company. No assurance can be given as to the Companys ability to enter into such an agreement or the Companys ability to successfully complete future funding.

9. LEASE OBLIGATIONS

On March 12, 2003, the Company entered into an operating lease for its current office space in Park Ridge, New Jersey. The initial lease commenced on March 31, 2003 and expired on March 31, 2007 and required monthly base
rental payments of $10,200 plus certain annual escalation. In December 2006 the Company entered into a five-year operating lease to rent different space in the same building where its prior offices were located, which commenced on April 1, 2007
and requires monthly base rental payments of $6,300 per month and expires on April 1, 2012.

The approximate aggregate minimum rental commitments on these leases are as follows:

F-9

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Year ending December 31,2008
      
      15,4002009
      
      92,4002010
      
      92,4002011
      
      92,4002012
      
      30,800Total minimum lease payments
      $
      323,400


Rental expense was $84,249 and $124,039 for the years ended December 31, 2007 and 2006 respectively.

10. RELATED PARTY TRANSACTIONS

None.

11. SUBSEQUENT EVENTS

On October 7, 2008 as part of the same bridge financing pursuant to which promissory notes were issued in May 2008 and July 2008, the Company issued promissory notes carrying 12% interest per annum having an aggregate face
value of $100,000, together with warrants to purchase an aggregate of 400,000 shares of the Companys common stock at $0.40 per share, to two investors. The Company increased the number of warrants issued per $1.00 invested from two
shares per $1.00 invested to four shares per $1.00 invested. Further, the Company decreased the price per share from $0.50 per share to $0.40 per share. Previous investors in the bridge financing will have their warrants adjusted
accordingly. The promissory notes shall be paid back the sooner of (i) upon their two year maturity date, or (ii) the Companys closing of financing equal to or greater than $2,000,000, and they are convertible into securities issued in
such financing at the holders discretion.

On November 1, 2008, (a) the Company entered into an agreement with its current landlord to vacate its headquarters effective November 15, 2008, and (b) executed a new lease with Goodrich Executive LLC. The Companys
new lease has a term of two years and 16 days and a monthly rent of (a) $1,919.50 from November 15, 2008 through November 30, 2009, and (b) $1,963.13 from December 1, 2009 through November 30, 2010. The new premises are located at 560 Sylvan
Avenue, 3rd Floor, Englewood Cliffs, New Jersey 07632. The premises consist of 1,047 square feet. Pursuant to the terms of the lease, the Company may use the premises for
executive and general offices and for no other purpose. The lease is a standard form of office lease. A copy of the rider to the lease is attached hereto as Exhibit 10.1.
This relocation will result in approximately $5,000 savings per month as compared to the Companys
previous lease.

F-10

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ITEM 2.      MANAGEMENTS DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

The following discussion and analysis should be read in conjunction with the Financial Statements and notes thereto appearing elsewhere in this quarterly report on Form 10-Q.

OVERVIEW

We are a biopharmaceutical company. We discovered and
are developing several novel compounds to address unmet needs in the area of
treatment resistant depression. We are
the successor company to Innapharma, Inc. (Innapharma) through a
reverse merger, which was completed upon Innapharmas emergence from Chapter
11 in 2004. Innapharma was founded in 1989 and had insignificant operating revenues
on the date of the merger.

OPERATING HISTORY

We are currently developing an antidepressant compound, Nemifitide, which is in late Phase 2 human clinical trials. During Phase 2 clinical development of Nemifitide, our studies were put on clinical hold by the Food and
Drug Administration (the FDA) as a result of some toxicity issues in a Beagle dog study that was completed in 2003. The FDA asked us to repeat the animal study and generate additional preclinical data with regard to the toxicity issue.
We completed a subsequent dog study and a primate study to address the FDAs concerns. After the final reports from these studies were submitted to the FDA, the FDA confirmed that this was a complete response to the clinical hold and therefore,
the clinical hold was lifted on March 29, 2006. In our preclinical development plans, we will evaluate the potential of other patented neuropeptides to treat other disorders, such as anorexia, bulimia, panic disorder, anxiety disorders and
post-traumatic stress disorder. We currently have three manufacturers synthesizing our compound, all of whom are located in Europe. We believe that we have sufficient Nemifitide bulk to meet our requirements for the foreseeable future. We intend to
either license Nemifitide out for the final stage of development or raise additional capital and continue the Phase 2/3 development of Nemifitide. We had designed a protocol which we believe, if positive, would satisfy one of the two required
pivotal trials by the FDA for drug approval. We are currently trying to secure the necessary financing to undertake a Phase 2/3 study of Nemifitide. We estimate the study to cost approximately $3,500,000.

In addition to the in-house development program, we intend to research and acquire existing compounds and replatform them for other therapeutic uses, and pursue a licensing agreement with the original inventor.

2

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In March 2008 we slashed costs and are now operating
with a core burn rate of slightly over $45,000
per month. We have sought measures to further reduce costs in the third quarter
2008 and have reduced the core burn rate of approximately $35,000 per month.
Our current cash on hand of $200,000 is adequate operating capital for approximately
seven months. We will continue to explore every possible avenue to raise additional
funding to permit us to continue to  operate and move our lead compound forward
through the development process.

We have excellent patent protection in all the significant worldwide markets. Additionally we have patented all of the surrounding peptides to Nemifitide as well.

State of New Jersey Development Plan

Since 2003, we have sold a portion of our tax losses through a development program sponsored by the State of New Jersey (the Development Plan). The Development Plan generated a net check to us in 2003 in excess
of $200,000, a check of over $400,000 in December of 2004, and an additional $315,000 in December 2005. In 2006, due to our merger with Innapharma, we only received $5,000 as part of the Development Plan. Although we applied to sell
a portion of our tax losses in 2007, due to a change in the standards of the Development Plan, our application was declined.

In October 2008 we were informed that we were approved to sell a portion of our state tax losses as part of the Development Plan. As a result, we expect to receive approximately $300,000 by the end of the year.

LIQUIDITY AND CAPITAL RESOURCES

As of November 10, 2008, we have approximately $200,000
in current assets and have a core burn rate of approximately $35,000 per
month. The $200,000 will be used primarily for operations going forward.
 Additional funds will be needed to fund further studies required by the FDA
to bring our lead compound, Nemifide, to market. Future funds will be derived
from additional sales of our common stock in the public or private markets and/or
a licensing  agreement with a pharmaceutical company as well as possibly the
sale of our state tax losses through the Development Plan. Our only significant
debt consists of a $1,800,000 convertible note payable to the former holders
of our Series D  Preferred securities which mature in April 2009.

The Three Months ending September 30, 2008 Compared to the Three Months ended September 30, 2007

Revenue We had no revenue from any source for the three months ending September 30, 2008 and 2007.

Research and Development Research
and development costs decreased to $0 for the three months ended September
30, 2008, a $11,223 decrease from $11,223 for the three
months ended September 30, 2007. No studies have been performed during 2007 or
2008, thus there have only been incidental expenses.

Compensation Expense Compensation expense decreased to $239,838 for the three months ended September 30, 2008, a $757,646 decrease from $997,484 for the three
months ended September 30, 2007. This was due to a reduction in salaries in April 2008 until we can locate additional funding. Additionally, no options have been granted to officers or directors in 2008. The majority of compensation expense was
being accrued as opposed to being paid out in cash.

3

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Travel Expense Travel expense decreased to $8,079 for the three months ended September 30, 2008, a $18,805 decrease from $26,884 for the three months ended
September 30, 2007. The decrease was due to less of a need to travel out-of-state for meetings.

Directors Fees Directors fees decreased to $12,500 for the three months ended September 30, 2008, a $1,109,215 decrease from $1,121,715 for the three
months ended September 30, 2007. This was due to no additional options being granted to directors in 2008.

Printing and Reproduction Printing and reproduction fees decreased to $2,618 for the three months ended September 30, 2008, a $42,556 decrease from $45,175 for the
three months ended September 30, 2007. This was due to no offering materials needing to be printed in 2008 as well as fewer filings with the SEC.

Telephone expense Telephone expense decreased to $2,758 for the three months ended September 30, 2008, a $823 decrease from $3,582 for the three months ended
September 30, 2007. This decrease was due to a newly negotiated telephone contract.

Consulting Fees Consulting expenses decreased to $0 for the three months ended September 30, 2008, a $180,615 decrease from $180, 615 for the three months ended
September 30, 2007. This decrease was a result of our not issuing options, warrants or conducting offerings during 2008. In addition in February 2008 we ceased payments to all scientific consultants until further notice.

The Nine Months ending September 30, 2008 Compared to the Nine Months ended September 30, 2007

Revenue We had no revenue from any source for the nine months ending September 30, 2008 and 2007.

Research and Development Research and development costs decreased to $7,900 for the nine months ended September 30, 2008, a $7,800 decrease from $15,700 for the
nine months ended September 30, 2007. No studies have been performed during 2007 or 2008 thus there have only been incidental expenses.

Compensation Expense Compensation expense decreased to $598,979 for the nine months ended September 30, 2008, a $817,843 decrease from $1,416,822 for the nine
months ended September 30, 2007.  This was due to a reduction in salaries in April 2008 until we can locate additional funding. Additionally, no options have been granted to officers or directors in 2008. The majority of compensation expense is
being accrued as opposed to being paid out in cash.

Travel Expense Travel expense decreased to $44,675 for the nine months ended September 30, 2008, a $23,376 decrease from $68,051 for the nine months ended September
30, 2007. The decrease was due to less of a need to travel out-of-state for meetings.

Directors Fees Directors fees decreased to $37,500 for the nine months ended September 30, 2008, a $1,108,500 decrease from $1,146,000 for the nine
months ended September 30, 2007. This was due to no additional options being granted to directors in 2008.

Printing and Reproduction Printing and reproduction fees decreased to $11,038 in the nine months ended September 30, 2008, a $37,144 decrease from $48,182 for the
nine months ended September 30, 2007. This is due to no offering materials needing to be printed in 2008 as well as fewer filings with the SEC.

4

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Telephone expense- Telephone expense decreased to $9,749 for the nine months ended September 30, 2008, a $6,627 decrease from $16,376 for the nine months ended September
30, 2007. The decrease was due to a newly negotiated telephone contract.

Consulting Fees Consulting expenses decreased to $15,282 for the nine months ended September 30, 2008, a $1,041,922 decrease from $1,057,204 for the nine months
ended September 30, 2007. This decrease was a result of our not issuing options, warrants or conducting offerings during 2008. In addition in February 2008 we ceased payments to all scientific consultants until further notice.

Disclosure Regarding Forward Looking Statements

This quarterly report on Form 10-Q includes forward looking statements which involve risks and uncertainties. Such statements can be identified by the use of forward-looking language such as will likely
result, may, are expected to, is anticipated, estimate, believes, projected, or similar words. All statements other than statements of historical fact included in this
section are forward-looking statements. Although we believe that the expectations reflected in such forward-looking statements are reasonable, we can give no assurance that such expectations will prove to have been correct. Our actual results could
differ materially from those anticipated in any such forward-looking statements as a result of various risks, including, without limitation, our dependence on a single line of business; rapid technological change; our inability to obtain adequate
financing; our inability to attract and retain key personnel and the potential volatility of our common stock.

ITEM 3. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK.

Not applicable.

ITEM 4T. CONTROLS AND PROCEDURES

(A) EVALUATION OF DISCLOSURE CONTROLS AND PROCEDURES

We maintain a system of disclosure controls and procedures (as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended (the Exchange Act)) that are designed to ensure that
information required to be disclosed in our Securities and Exchange Commission reports is recorded, processed, summarized and reported within the time periods specified in the Securities and Exchange Commissions rules and forms, and to ensure
that such information is accumulated and communicated to our management, including the Chief Executive Officer and the Chief Financial Officer, as appropriate, to allow timely decisions regarding required disclosure. Management necessarily applied
its judgment in assessing the costs and benefits of such controls and procedures, which, by their nature, can provide only reasonable assurance regarding managements control objectives.

Management, with the participation of our Chief Executive Officer and Chief Financial Officer, has evaluated the effectiveness of our disclosure controls and procedures, as of the end of the period covered by this Quarterly
Report on Form 10-Q. Based upon this evaluation, management concluded that our disclosure controls and procedures were not effective as of the end of September 30, 2008.

(C) CHANGES IN INTERNAL CONTROLS OVER FINANCIAL REPORTING

There have been no significant changes in our internal controls over financial reporting during the quarter ended September 30, 2008 that have altered our conclusion as to the ineffectiveness of such controls.

5

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PART II: OTHER INFORMATION

ITEM 1.      LEGAL PROCEEDINGS

In the normal course of business, there may be various legal actions and proceedings pending which seek damages against us. As of September 30, 2008, we are not party to any material legal proceedings, nor to our knowledge,
are there any proceedings threatened against us.

ITEM 2.        UNREGISTERED SALES OF EQUITY
SECURITIES AND USE OF PROCEEDS

On May 28, 2008, as part of a bridge financing, we issued promissory notes carrying 12% interest per annum having an aggregate face value of $175,000, together with warrants to purchase 350,000 shares of our common
stock at $0.50 per share, to seven individuals. The promissory notes shall be paid back the sooner of (i) upon their two year maturity date, or (ii) our closing of financing equal to or greater than $2,000,000, and they are convertible into
securities issued in such financing at the holders discretion.

On July 28, 2008, as part of the same bridge financing, we issued promissory notes carrying 12% interest per annum having an aggregate face value of $75,000, together with warrants to purchase an aggregate of 150,000
shares of our common stock at $0.50 per share, to three investors. The promissory notes shall be paid back the sooner of (i) upon their two year maturity date, or (ii) our closing of financing equal to or greater than $2,000,000, and they
are convertible into securities issued in such financing at the holders discretion.

The proceeds from the foregoing issuances of promissory notes were used for working capital purposes.

The investors in the foregoing issuances had an opportunity to ask questions of and receive answers from our executive officers and were provided with access to our documents and records in order to verify the information
provided.

The foregoing issuances of securities were effected in reliance on the exemption provided by Section 4(2) of the Securities Act of 1933, as amended and Rule 506 of Regulation D promulgated thereunder based on the limited
number of purchases, their sophistication in financial matters, and their access to information concerning our business.

ITEM 3.        DEFAULTS ON SENIOR SECURITIES

None.

ITEM 4.        SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

No matters were submitted to a vote of security holders
during the quarter ended September 30, 2008.

ITEM 5.      OTHER INFORMATION

Lease

On November 1, 2008, (a) we entered into an agreement with our current landlord to vacate our current headquarters effective November 15, 2008, and (b) executed a new lease with Goodrich Executive LLC.

6

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Our new lease has a term of two years and 16 days and a monthly rent of (a) $1,919.50 from November 15, 2008 through November 30, 2009, and (b) $1,963.13 from December 1, 2009 through November 30, 2010. The new
premises are located at 560 Sylvan Avenue, 3rdFloor, Englewood Cliffs, New Jersey 07632. The premises consist of 1,047 square feet. Pursuant to the terms of the lease, we
may use the premises for executive and general offices and for no other purpose. The lease is a standard form of office lease. A copy of the rider to the lease is attached hereto as Exhibit 10.1. This relocation will result in approximately
$5,000 savings per month as compared to our previous lease.

Sale of Unregistered Securities

On October 7, 2008, as part of the same bridge financing
pursuant to which promissory notes were issued in May 2008 and July 2008, we
issued promissory notes carrying 12% interest per annum having an aggregate face
value of $100,000,
together with warrants to purchase an aggregate of 400,000 shares of our common
stock at $0.40
per share, to 2 investors. We increased the number of warrants issued in October
per $1.00
invested from two shares per $1.00 to four shares per $1.00. Further,
we decreased the price per share from
$0.50 per share to $0.40 per share. Previous investors in the bridge
financing will have their warrants adjusted accordingly. The promissory notes
shall be paid back the sooner of (i) upon their two year maturity date, or (ii)
our closing of  financing equal to or greater than $2,000,000, and they are
convertible into securities issued in such financing at the holders discretion.

The proceeds from the foregoing issuances of promissory notes were used for working capital purposes.

The investors in the foregoing issuances had an opportunity to ask questions of and receive answers from our executive officers and were provided with access to our documents and records in order to verify the information
provided.

The foregoing issuances of securities were effected in reliance on the exemption provided by Section 4(2) of the Securities Act of 1933, as amended and Rule 506 of Regulation D promulgated thereunder based on the limited
number of purchases, their sophistication in financial matters, and their access to information concerning our business.

7

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|        |  |                                                                                                                                            
|------- |  | -------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit |  | Description                                                                                                                                
|No.     |  |                                                                                                                                            
|10.1    |  | Rider to lease between Goodrich Executive
    LLC, as landlord and Tetragenex Pharmaceuticals, Inc., as tenants, dated
    November 1, 2008
|        |  |                                                                                                                                            
|31.1    |  | Certification of Co-Chief Operating Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002                                      
|        |  |                                                                                                                                            
|31.2    |  | Certification of Chief Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002                                         
|        |  |                                                                                                                                            
|32.1    |  | Certification of the Co-Chief Executive Officer Pursuant to 18 U.S.C. Section 1350, Section 906 of the Sarbanes-Oxley Act of 2002          
|        |  |                                                                                                                                            
|32.2    |  | Certification of the Chief Financial Officer Pursuant to 18 U.S.C. Section 1350, Section 906 of the Sarbanes-Oxley Act of 2002             

8

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SIGNATURES

Pursuant to the requirements of Section 13(a) and 15(d) of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

|                  |  | TETRAGENEX PHARMACEUTICALS, INC.
|----------------- |  | --------------------------------
|                 
|November 14, 2008 |  | /s/Martin Schacker              
|                  |  | Martin Schacker                 
|                  |  | Co-Chief Executive Officer      
|                 
|                 
|November 14, 2008 |  | /s/Neil Martucci                
|                  |  | Neil Martucci                   
|                  |  | Chief Financial Officer         

9

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EXHIBIT INDEX

|        |  |                                                                                                                                            
|------- |  | -------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit |  |                                                                                                                                            
|No.     |  | Description                                                                                                                                
|10.1    |  | Rider to lease between Goodrich Executive
    LLC, as landlord, and Tetragenex Pharmaceuticals, Inc., as tenant, dated
    November 1, 2008
|        |  |                                                                                                                                            
|31.1    |  | Certification of Co-Chief Operating Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002                                      
|        |  |                                                                                                                                            
|31.2    |  | Certification of Chief Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002                                         
|        |  |                                                                                                                                            
|32.1    |  | Certification of the Co-Chief Executive Officer Pursuant to 18 U.S.C. Section 1350, Section 906 of the Sarbanes-Oxley Act of 2002          
|        |  |                                                                                                                                            
|32.2    |  | Certification of the Chief Financial Officer Pursuant to 18 U.S.C. Section 1350, Section 906 of the Sarbanes-Oxley Act of 2002             

---